An article in the journal Bioinformatics from researchers at the University of Colorado Cancer Center describes a new tool that improves the ability to match drugs to disease: the Kinase Addiction Ranker predicts what genetics are truly driving the cancer in any population of cells and chooses the best 'kinase inhibitor' to silence these dangerous genetic causes of disease.
Working at the Advanced Light Source, Berkeley Lab researchers have observed 'Luttinger-liquid' plasmons in metallic single-walled nanotubes. This holds great promise for novel plasmonic and nanophotonic devices over a broad frequency range, including telecom wavelengths.
Whether you're a human, a mouse, or even a fruitfly, losing sleep is a bad thing, leading to physiological effects and behavioral changes. Researchers used fruitflies to probe deeper into the cellular and molecular mechanisms that govern aggression and sleep and found that sleep deprivation reduces aggression in fruitflies and affects their reproductive fitness. They identified a related molecular pathway that might govern recovery of normal aggressive behaviors.
A recent study demonstrates the rapid control of phase-changes in resonantly bonded materials.
A new big data study conducted by researchers from the Regenstrief Institute and Indiana University has found that a drug commonly prescribed to conserve potassium in the blood also significantly lowers blood pressure when taken in conjunction with a diuretic frequently prescribed to patients with hypertension. The combination of the two drugs, both available as generics, has been shown to consistently amplify the blood pressure reduction in patients with or without the presence of other antihypertensive agents such as ACE inhibitors and calcium channel blockers.
Researchers at Princeton have developed a new chemical reaction that breaks the strongest bond in a molecule instead of the weakest, completely reversing the norm for reactions in which bonds are evenly split to form reactive intermediates. Published on July 13 in the Journal of the American Chemical Society, the non-conventional reaction is a proof of concept that will allow chemists to access compounds that are normally off-limits to this pathway.
In a new article for GSA Today, authors Benjamin DeJong and colleagues write that sea-level rise (3.4 mm/yr) is faster in the Chesapeake Bay region than any other location on the Atlantic coast of North America, and twice the global average (1.7 mm/yr). They have found that dated interglacial deposits suggest that relative sea levels in the Chesapeake Bay region deviate from global trends over a range of timescales.
Sergei Maslov, a computational biologist at the US Department of Energy's Brookhaven National Laboratory and adjunct professor at Stony Brook University, and Alexei Tkachenko, a scientist at Brookhaven's Center for Functional Nanomaterials, have developed a model that explains how simple monomers could rapidly make the jump to more complex self-replicating polymers. What their model points to could have intriguing implications for the origins of life on Earth and CFN's work in engineering artificial self-assembly at the nanoscale.
For the first time, researchers have directly seen how organic molecules bind to other materials at the atomic level. Using a special kind of electron microscopy, this information can lead to increasing the life span of electronic devices, for example.
Physicists like to study unusual kinds of waves, like freak waves found in the sea. Such wave movements can be studied using models designed to describe the dynamics of disturbances. Theoretical physicists have focused on finding ways of best explaining how wave disturbance occurs under very specific initial conditions. They looked for solutions to this puzzle by resolving a type of equation, called the nonlinear Schrödinger equation. The findings have been published in EPJ D.