Researchers have shown how anti-HIV protein inhibitor drugs can bind to the wrong protein, causing unwanted side effects.
One approach to HIV vaccine development relies on broadly neutralizing antibodies (bnAbs), highly evolved and unusual antibodies that protect against different circulating HIV strains. A study published on Aug. 25 in PLOS Pathogens reports on a rational approach to identify the essential features of bnAbs, simplify them to be more suitable leads for HIV vaccine design, and then use analysis of the simplified bnAbs to guide design of vaccine proteins to elicit similar antibodies.
Penicilliosis, caused by the fungus Talaromyces marneffei, is a major opportunistic infection in Southeast Asia. A study published in PLOS Neglected Tropical Diseases reports that the fungal protein Mp1p is responsible for the pathogen's ability to cause disease in mice, and that it does so by allowing survival of the fungus in macrophages.
Among more than 26,000 human immunodeficiency virus (HIV)-infected adults, those with major depressive disorder (MDD) were more likely to experience a heart attack than those without MDD, according to a study published online by JAMA Cardiology.
Researchers at the Skaggs School of Pharmacy and Pharmaceutical Sciences at CU Anschutz have developed a technique that estimates an HIV-negative patient's adherence to drugs prescribed to prevent HIV transmission during sex.
A study from Emory AIDS researchers shows how the expected disease severity when someone is newly infected by HIV reflects a balance between the virus' invisibility to the host's immune system and its ability to reproduce.
Researchers at the University at Buffalo developed and tested a smartphone app that allows people living with HIV to self-report on sensitive health behaviors, which may help facilitate faster interventions when necessary.
Providing HIV medication to both members of a couple may substantially reduce the risk of transmission within that couple, according to a study in PLOS Medicine.
Vincent Habiyambere of the World Health Organization and colleagues find that insufficient capacity to perform laboratory tests used in monitoring HIV infection, and underutilization of existing testing capacity, are limiting the ability to meet the Joint United Nations Programme on HIV and AIDS 90-90-90 targets, in a study appearing in PLOS Medicine.
People in Africa's Sub-Sahara region, a relatively undeveloped area, are generally satisfied with their sex lives, with the most common rating -- reported by 18 percent of survey respondents -- being a perfect '10,' according to Baylor University research to be presented Monday at the 111th Annual Meeting of the American Sociological Association.