In this month's issue of the JCI, a team led by Ted Dawson and Han Seok Ko at Johns Hopkins School of Medicine determined that activation of a protein called c-Abl exacerbates α-synuclein accumulation and the appearance of behavioral hallmarks of Parkinson's disease in mice.
Researchers in Japan have engineered an artificial switch that could let scientists turn individual neurotransmitter receptors on and off. Shedding light on these receptors' role in memory formation could contribute to the development of new drugs for neurological diseases, including Alzheimer's, Parkinson's, and ALS.
Researchers at Johns Hopkins say they have gleaned two important new clues in the fight against Parkinson's disease: that blocking an enzyme called c-Abl prevents the disease in specially bred mice, and that a chemical tag on a second protein may signal the disorder's presence and progression.
Replacing dopamine-producing cells in the brain represents a promising therapeutic approach in Parkinson's disease, and a new study shows how post-transplantation gamma-ray irradiation can reduce the risk of tumor formation. The study, in which human induced pluripotent stem (iPS) cell-derived neural progenitor cells were grafted into rat brains, is published in Stem Cells and Development.
A study publish in the journal Cell indicates that two genes associated with Parkinson's disease are key regulators of the immune system, providing direct evidence linking Parkinson's to autoimmune disease.
MRC researchers at University of Leicester investigate 'mutant flies.'
A team of scientists has completed the first large-scale assessment of single neuronal 'transcriptomes.' Their research reveals a surprising diversity in the molecules that human brain cells use in transcribing genetic information from DNA to RNA and producing proteins.
The incidence of Parkinson's disease and parkinsonism increased significantly in 30 years from 1976 to 2005, Mayo Clinic researchers reported today in a study in JAMA Neurology. This trend was noted in particular for men age 70 and older. According to the researchers, this is the first study to suggest such an increasing trend.
A study of patients in a Minnesota county suggests the incidence (new cases) of parkinsonism and Parkinson's disease may have increased over the past 30 years but that trend may not be genuine and must be confirmed in other populations, according to an article published online by JAMA Neurology.
A natural molecule shows benefit in a preliminary clinical trial for Parkinson's disease.