UCSB neuroscientist Kenneth Kosik stands up for basic cell biology research.
New work dispels long-held notions about area involved in Parkinson's and addiction.
An international clinical trial has found that focused ultrasound offers essential tremor patients a lasting reduction in their uncontrollable shaking. And the procedure's entirely scalpel free.
Scientists from the Institut Pasteur have demonstrated the role of lysosomal vesicles in transporting α-synuclein aggregates, responsible for Parkinson's and other neurodegenerative diseases, between neurons. These proteins move from one neuron to the next in lysosomal vesicles which travel along the 'tunneling nanotubes' between cells. These findings were published in The EMBO Journal on Aug. 22, 2016.
Scientists at the Institute for Research in Biomedicine have rediscovered the utility of disordered regions of proteins as drug targets. Published in the journal ACS Chemical Biology, the results pave the way towards identifying new therapeutic targets for many diseases.
Neuroscientists peered into the brains of patients with Parkinson's disease and two similar conditions to see how their neural responses changed over time. The study, funded by the NIH's Parkinson's Disease Biomarkers Program and published in Neurology, may provide a new tool for testing experimental medications aimed at alleviating symptoms and slowing the rate at which the diseases damage the brain.
A new, non-invasive way to track the progression of Parkinson's disease could help evaluate experimental treatments to slow or stop the disease's progression.
Loss of synapses and synapse function sit at the heart of a number of diseases, not just neurodegenerative examples such as dementia and Parkinson's disease but also conditions such as diabetes. We do not fully understand how synapses work, but new research published on Nature Neuroscience's website has shed new light on the role of proteins in the way in which synapses maintain their signalling.
Researchers identify gene silencing mechanism that maintains neuronal specification and protects against neurodegeneration.
Researchers at Yerkes National Primate Research Center, Emory University, are the first to systematically record neural activity in the human striatum, a deep brain structure that plays a major role in cognitive and motor function. These two functions are compromised in Parkinson's disease, which makes the neuron-firing abnormalities the study results revealed key to better understanding the pathophysiology of PD and, ultimately, developing better treatments and preventions.