Though the drug levodopa can dramatically improve Parkinson's disease symptoms, within five years one-half of the patients using L-DOPA develop an irreversible condition -- involuntary repetitive, rapid and jerky movements. UAB researchers have uncovered an essential mechanism of long-term memory for L-DOPA-induced-dyskinesia: widespread reorganization of DNA methylation, and this may be a therapeutic target to prevent or reverse dyskinesia.
Clues that point toward new risk mechanisms for developing Parkinson's disease are hiding in some unusual spots, according to a study published today in Scientific Reports.
New safety data from a study of patients with advanced Parkinson's disease five years after gene transfer-mediated delivery of the neuroprotective factor neurturin directly to patients' brains reveal no serious adverse events related to the treatment. The encouraging long-term safety profile of the surgically administered adeno-associated virus (AAV2)-neurturin gene therapy is described in an article in Human Gene Therapy.
In the Proceedings of the National Academy of Sciences, a team led by Brown University neuroscientists proposes a new theory -- backed by data from people, animal models and computational simulation -- to explain how beta waves emerge in the brain.
A research team with Rush University and the Jesse Brown Veterans Affairs Medical Center in Chicago has found that cinnamon turns poor learners into good ones, at least among mice. The scientists hope the same will hold true for people.
What makes people incapable of controlling their most everyday voluntary motions -- and in some cases, their thoughts -- thus enslaving them in endless repetition of the same action, or in endless change from one action to another?
Autophagy is one of the most important process by which cells renew themselves and eliminate components no longer functional. In short, they recycle. The current view of autophagy portaits two completely separated processes, each one dedicated to remove specific elements. Now a research from Neuromed Institute, Pozzilli (Italy), shows that the two paths converge in a single cell component: the autophagoproteasome.
A Yale-led team of researchers developed a new approach to scanning the brain for changes in synapses that are associated with common brain disorders. The technique may provide insights into the diagnosis and treatment of a broad range of disorders, including epilepsy and Alzheimer's disease.
UAB researchers and colleagues have shown that the most common genetic cause of Parkinson's disease -- a mutant LRRK2 kinase enzyme -- contributes to the formation of inclusions in neurons, resembling one of the hallmark pathologies seen in Parkinson's disease. These inclusions are made up of aggregated alpha synuclein protein, which -- the research also shows -- can be prevented from forming by using two LRRK2 kinase inhibitor drugs now being developed for clinical use.
The ability to switch disease-causing genes on and off remains a dream for many physicians, research scientists and patients. A team from Charité - Universitätsmedizin Berlin and the Max Planck Institute for Medical Research in Heidelberg led by Dr. Mazahir T. Hasan has successfully programmed a virus to transport the necessary genetic material to affected tissue and nerve cells inside the body, as published in the journal Molecular Therapy Nucleic Acids*.