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Key: Meeting Journal Funder
Public Release: 14-Sep-2014
Genes & Development
UNC researchers find final pieces to the circadian clock puzzle
UNC researchers discovered how two genes -- Period and Cryptochrome -- keep the circadian clocks in cells in proper rhythm with the 24-hour day. The finding has implications for drug development for various diseases including cancer and conditions such as jetlag and season affective disorder.
National Institutes of Health, Science Research Council, Academia Sinica in Taiwan

Contact: Mark Derewicz
mark.derewicz@unch.unc.edu
919-923-0959
University of North Carolina Health Care

Public Release: 14-Sep-2014
Nature Genetics
Genetic testing can identify men at 6-fold increased risk of prostate cancer
Scientists can now explain one-hird of the inherited risk of prostate cancer, after a major international study identified 23 new genetic variants associated with increased risk of the disease.
Cancer Research UK, Prostate Cancer UK, European Union, National Institutes for Health

Contact: Graham Shaw
graham.shaw@icr.ac.uk
44-207-153-5380
Institute of Cancer Research

Public Release: 14-Sep-2014
Nature
New insights in survival strategies of bacteria
Bacteria are particularly ingenious when it comes to survival strategies. They often create a biofilm to protect themselves from a hostile environment, e.g. during antibiotics treatment. A biofilm is a bacterial community surrounded by protective slime capsule consisting of sugar chains and 'curli.' VIB/VUB scientist have created a detailed 3-D image of the pores through which curli building blocks cross the bacterial cell wall, a crucial step in the formation of the protective slime capsule.

Contact: Sooike Stoops
sooike.stoops@vib.be
32-474-289-252
VIB (the Flanders Institute for Biotechnology)

Public Release: 14-Sep-2014
Nature Biotechnology
Measuring modified protein structures
ETH-Zurich researchers have developed a new approach to measure proteins with structures that change. This could enable new diagnostic tools for the early recognition of neurodegenerative diseases to be developed.
Swiss National Science Foundation, EU Seventh Framework Program Reintegration, Promedica Stiftung

Contact: Paola Picotti
paola.picotti@bc.biol.ethz.ch
41-446-332-558
ETH Zurich

Public Release: 14-Sep-2014
Nature
How an ancient vertebrate uses familiar tools to build a strange-looking head
In this study, Investigator and Scientific Director Robb Krumlauf, Ph.D., and colleagues show that the sea lamprey Petromyzon marinus, a survivor of ancient jawless vertebrates, exhibits a pattern of gene expression that is reminiscent of its jawed cousins, who evolved much, much later.
Stowers Institute, National Institutes of Health

Contact: Kim Bland, Ph.D.
ksb@stowers.org
816-392-8428
Stowers Institute for Medical Research

Public Release: 14-Sep-2014
Nature
Asian monsoon much older than previously thought
The Asian monsoon already existed 40 million years ago during a period of high atmospheric carbon dioxide and warmer temperatures, an international research team led by a University of Arizona geoscientist reports in the journal Nature. Scientists thought the climate pattern known as the Asian monsoon began 22-25 million years ago as a result of the uplift of the Tibetan Plateau and the Himalaya Mountains.
French National Research Agency, Universities of Poitiers and Nancy, Netherlands Organisation for Scientific Research, Marie Curie Career Integration, Ministry of Culture of the Republic of the Union of Myanmar

Contact: Mari N. Jensen
mnjensen@email.arizona.edu
520-626-9635
University of Arizona

Public Release: 14-Sep-2014
Nature Medicine
Muscular dystrophy: Repair the muscles, not the genetic defect
A potential way to treat muscular dystrophy directly targets muscle repair instead of the underlying genetic defect that usually leads to the disease.
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH/National Institute of Neurological Disorders and Stroke

Contact: Laura Bailey
baileylm@umich.edu
734-647-1848
University of Michigan

Public Release: 14-Sep-2014
Nature Medicine
Blood-cleansing biospleen device developed for sepsis therapy
Things can go downhill fast when a patient has sepsis, a life-threatening condition in which bacteria or fungi multiply in a patient's blood -- often too fast for antibiotics to help. A new device inspired by the human spleen and developed by a team at Harvard's Wyss Institute for Biologically Inspired Engineering may radically transform the way doctors treat sepsis.
Defense Advanced Research Projects Agency, DOD/Center for Integration of Medicine and Innovative Technology, Harvard's Wyss Institute

Contact: Kristen Kusek
kristen.kusek@wyss.harvard.edu
617-432-8266
Wyss Institute for Biologically Inspired Engineering at Harvard

Public Release: 14-Sep-2014
Nature
Nature: New drug blocks gene driving cancer growth
When active, the protein called Ral can drive tumor growth and metastasis in several human cancers including pancreatic, prostate, lung, colon and bladder. Unfortunately, drugs that block its activity are not available. A study published today in the journal Nature uses a novel approach to target the activation of these Ral proteins.
National Institutes of Health

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

Public Release: 13-Sep-2014
Angewandte Chemie International Edition
Decoding 'sweet codes' that determine protein fates
The research group lead by Professor Koichi Kato of the Institute for Molecular Science, National Institutes of Natural Sciences developed a methodology for quantitatively describing the dynamic behaviors of complicated sugar chains in solution at atomic resolution by combining a sophisticated NMR spectroscopic approach with an ingenious molecular dynamics simulation technique. This study has just been published in Angewandte Chemie International Edition (published online on Sept.4, 2014).

Contact: Koichi Kato
kkatonmr@ims.ac.jp
National Institutes of Natural Sciences

Public Release: 13-Sep-2014
Technology
Milestone reached in work to build replacement kidneys in the lab
Regenerative medicine researchers at Wake Forest Baptist Medical Center have addressed a major challenge in the quest to build replacement kidneys in the lab. Working with human-sized pig kidneys, the scientists developed the most successful method to date to keep blood vessels in the new organs open and flowing with blood. The work is reported in journal Technology.
US Army Medical Research and Materiel Command

Contact: Philly Lim
mllim@wspc.com
656-466-5775
World Scientific

Public Release: 12-Sep-2014
Journal of Bone and Mineral Research
USC researchers discover the healing power of 'rib-tickling'
Unlike salamanders, mammals can't regenerate lost limbs, but they can repair large sections of their ribs. In a new study in the Journal of Bone and Mineral Research, a team directed by USC Stem Cell researcher Francesca Mariani takes a closer look at rib regeneration in both humans and mice.
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases

Contact: Cristy Lytal
lytal@med.usc.edu
323-442-2172
University of Southern California - Health Sciences

Public Release: 12-Sep-2014
Proceedings of the National Academy of Sciences
New glaucoma culprit is found
In a unique study of human ocular cells, a multi-institution team led by a Northwestern University biomedical engineer has found that endothelial cells in Schlemm's canal -- important for draining fluid from the eye -- are stiffer in eyes with glaucoma than those in healthy eyes. The resulting increased flow resistance is responsible for the elevated pressure associated with glaucoma. Therapeutic strategies that alter the stiffness of these cells could lead to a cure for this debilitating disease.
National Institutes of Health, Bright Focus Foundation

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University

Public Release: 12-Sep-2014
Applied and Environmental Microbiology
Boosting armor for nuclear-waste eating microbes
A microbe developed to clean up nuclear waste and patented by a Michigan State University researcher has just been improved. In earlier research, Gemma Reguera, Michigan State University microbiologist, identified that Geobacter bacteria's tiny conductive hair-like appendages, or pili, did the yeoman's share of remediation. By increasing the strength of the pili nanowires, she improved their ability to clean up uranium and other toxic wastes.

Contact: Layne Cameron
layne.cameron@cabs.msu.edu
517-353-8819
Michigan State University

Public Release: 12-Sep-2014
Selway complex and Johnson Bar fires in Idaho
Two fires are seen burning in this satellite image taken by the Aqua satellite on September 11, 2014.
NASA

Contact: Rob Gutro
robert.j.gutro@nasa.gov
NASA/Goddard Space Flight Center

Public Release: 12-Sep-2014
Journal of Applied Meteorology and Climatology
Getting hot and wet in Vermont
A fundamental challenge of climate change forecasting is how to bridge the gap between global-scale models and local impacts. A new study -- the first-of-its kind for the Lake Champlain region -- bridges this gap and forecasts that northern Vermont and southern Quebec by 2100 will get eight degrees Fahrenheit hotter; Burlington, Vt., will experience 10 more days in July above 90; and ski resorts will see 50 percent less snowfall.
National Science Foundation

Contact: Joshua Brown
joshua.e.brown@uvm.edu
802-656-3039
University of Vermont

Public Release: 12-Sep-2014
Nature
CCNY analysis explains rich bird biodiversity in Neotropics
Applying analyses designed by City College of New York biologist Mike Hickerson, a team of international researchers is challenging a commonly held view that explains how so many species of birds ended up in the Neotropics, an area rich in rain forest extending from Mexico to the southernmost tip of South America. It is home to the most bird species on Earth.

Contact: Jay Mwamba
jmwamba@ccny.cuny.edu
212-650-7580
City College of New York

Public Release: 12-Sep-2014
Nature Communications
The shadow of a disease
A biosensor for the scattered light of individual unmarked biomolecules such as proteins and tumor markers may facilitate medical diagnosis. The biodetector, that a team led by V. Sandoghdar has developed at the Max Planck Institute for the Science of Light, uses the interferometric method iSCAT.

Contact: Vahid Sandoghdar
vahid.sandoghdar@mpl.mpg.de
49-091-316-877-200
Max-Planck-Gesellschaft

Public Release: 12-Sep-2014
PLOS Genetics
Corn spots: Study finds important genes in defense response
What gives corn its spots? NC State researchers scour corn genome to find candidate genes that control an important defense response.
US Department of Agriculture, National Science Foundation

Contact: Dr. Peter Balint-Kurti
pjbalint@ncsu.edu
919-515-3516
North Carolina State University

Public Release: 12-Sep-2014
EMBO Molecular Medicine
Dendritic cells affect onset and progress of psoriasis
Different types of dendritic cells in human skin have assorted functions in the early and more advanced stages of psoriasis report researchers in the journal EMBO Molecular Medicine. The scientists suggest that new strategies to regulate the composition of dendritic cells in psoriatic skin lesions might represent an approach for the future treatment of the disease.

Contact: Barry Whyte
barry.whyte@embo.org
EMBO

Public Release: 12-Sep-2014
Parasite Immunology
Piglet health
Parasitologists from the University of Veterinary Medicine of Vienna are closer to understanding the disease process behind porcine neonatal coccidiosis. The disease affects piglets during the first days of their life and can cause heavy diarrhea in the animals. The parasite Cystoisospora suis damages the intestinal mucosa to such a degree that it threatens the growth and survival of the pigs. The researchers have now analyzed the immune response to the infection. The results were published in the journal Parasite Immunology.

Contact: Dr. Simone Gabner
simone.gabner@vetmeduni.ac.at
43-125-077-3402
University of Veterinary Medicine -- Vienna

Public Release: 12-Sep-2014
Biophysical Reviews and Letters
Conjecture on the lateral growth of Type I collagen fibrils
Research building on recent model using the algorithm of phyllotaxis to build a dense organization of triple helices in fibrils with circular symmetry.

Contact: Philly Lim
mllim@wspc.com
656-466-5775
World Scientific

Public Release: 12-Sep-2014
Science
From worm muscle to spinal discs
Thoughts of the family tree may not be uppermost in the mind of a person suffering from a slipped disc, but those spinal discs provide a window into our evolutionary past. They are remnants of the first vertebrate skeleton, whose origins now appear to be older than had been assumed. Scientists at EMBL Heidelberg have found that, unexpectedly, this skeleton most likely evolved from a muscle.

Contact: Sonia Furtado Neves
sonia.furtado@embl.de
European Molecular Biology Laboratory

Public Release: 12-Sep-2014
International Journal of Information Technology, Communications and Convergence
Cutting the cloud computing carbon cost
Writing in the International Journal of Information Technology, Communications and Convergence, researchers at the University of Oran in Algeria, have investigated how cloud computing systems might be optimized for energy use and to reduce their carbon footprint.

Contact: Albert Ang
press@inderscience.com
Inderscience Publishers

Public Release: 12-Sep-2014
PLOS ONE
Study solves the bluetongue disease 'overwintering' mystery
Veterinary researchers monitoring a Northern California dairy farm discovered how the bluetongue virus survives the cold winter months by hiding out in the tiny biting midge that transmits the virus.
US Department of Agriculture - National Institute of Food and Agriculture, UC Davis School of Veterinary Medicine

Contact: Patricia Bailey
pjbailey@ucdavis.edu
530-752-9843
University of California - Davis