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Medicine/Health
Key: Meeting Journal Funder
Public Release: 25-Apr-2014
British Sociological Association Annual Conference 2014
Couples need just 1 conversation to decide not to have children
Many couples agree not to have children after only one discussion, and sometimes none at all.

Contact: Tony Trueman
tony.trueman@britsoc.org.uk
44-796-402-3392
British Sociological Association

Public Release: 25-Apr-2014
Molecular Systems Biology
Reconstructed ancient ocean reveals secrets about the origin of life
A reconstruction of Earth's earliest ocean in the laboratory reveals the spontaneous occurrence of the chemical reactions used by modern cells to synthesize many of the crucial organic molecules of metabolism.

Contact: Barry Whyte
barry.whyte@embo.org
European Molecular Biology Organization

Public Release: 24-Apr-2014
Journal of Clinical Investigation
JCI online ahead of print table of contents for April 24, 2014
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers published online, April 24, 2014, in the JCI: 'Ex vivo expansion of hematopoietic stem cells from cord blood,' 'Receptors in the brain mediate the weight loss effects of GLP1 agonists,' 'Peripheral nervous system plasmalogens regulate Schwann cell differentiation and myelination,' 'Estrogen promotes Leydig cell engulfment by macrophages in male infertility,' and more.

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 24-Apr-2014
Human-Animal Interaction Bulletin
'Horsing around' reduces stress hormones in youth
New research from Washington State University reveals how youth who work with horses experience a substantial reduction in stress -- and the evidence lies in kids' saliva.
National Institutes of Health

Contact: Patricia Pendry
ppendry@wsu.edu
509-335-8365
Washington State University

Public Release: 24-Apr-2014
Lancet Respiratory Medicine
Vanderbilt study finds physical signs of depression common among ICU survivors
Depression affects more than one out of three survivors of critical illness, according to a Vanderbilt study released in The Lancet Respiratory Medicine, and the majority of patients experience their symptoms physically rather than mentally.
National Institutes of Health

Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center

Public Release: 24-Apr-2014
New England Journal of Medicine
HHS leaders call for expanded use of medications to combat opioid overdose epidemic
A national response to the epidemic of prescription opioid overdose deaths was outlined yesterday in the New England Journal of Medicine by leaders of agencies in the US Department of Health and Human Services. The commentary calls upon health care providers to expand their use of medications to treat opioid addiction and reduce overdose deaths, and describes a number of misperceptions that have limited access to these potentially life-saving medications.
NIH/National Institute on Drug Abuse, Centers for Disease Control and Prevention, Substance Abuse and Mental Health Services Administration, Centers for Medicare and Medicaid Services

Contact: NIDA Press Team
media@nida.nih.gov
301-443-6245
NIH/National Institute on Drug Abuse

Public Release: 24-Apr-2014
Biomedical Optics Express
Bake your own droplet lens
Researchers have created a new type of lens that costs less than a penny to make, and can be used in a 3-D printed attachment that turns a Smartphone into a dermascope, a tool to diagnose skin diseases like melanoma. Normal dermascopes can cost $500 or more, but this version costs a mere $2 and is slated to be commercially available in just a few months. The work was published today in the journal Biomedical Optics Express.

Contact: Angela Stark
astark@osa.org
202-416-1443
The Optical Society

Public Release: 24-Apr-2014
International Journal of Cancer
Breast cancer replicates brain development process
New research led by a scientist at the University of York reveals that a process that forms a key element in the development of the nervous system may also play a pivotal role in the spread of breast cancer.
United Kingdom Medical Research Council

Contact: David Garner
david.garner@york.ac.uk
44-019-043-22153
University of York

Public Release: 24-Apr-2014
Stem Cell Reports
Skin layer grown from human stem cells could replace animals in drug and cosmetics testing
An international team led by King's College London and the San Francisco Veteran Affairs Medical Center has developed the first lab-grown epidermis -- the outermost skin layer -- with a functional permeability barrier akin to real skin. The new epidermis, grown from human pluripotent stem cells, offers a cost-effective alternative lab model for testing drugs and cosmetics, and could also help to develop new therapies for rare and common skin disorders.

Contact: Jenny Gimpel
jenny.gimpel@kcl.ac.uk
44-020-784-84334
King's College London

Public Release: 24-Apr-2014
Genome Announcements
Novel therapeutic agent for Tamiflu-resistant pH1N1 influenza virus discovered
Researchers at the Institute for Molecular Medicine Finland FIMM, University of Helsinki, with their collaborators have shown that first Tamiflu resistant pandemic influenza pH1N1 viruses have emerged in Finland. Furthermore, they have identified a novel antiviral agent MK2206 and shown that the pH1N1 viruses are not able to develop resistance against it.

Contact: Denis Kainov
denis.kainov@fimm.fi
358-504-152-35460
University of Helsinki

Public Release: 24-Apr-2014
IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
New ultrasound device may add in detecting risk for heart attack, stroke
Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have developed a new ultrasound device that could help identify arterial plaque that is at high risk of breaking off and causing heart attack or stroke.
National Institutes of Health

Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University

Public Release: 24-Apr-2014
mBio
Treatment for deadly yeast disease reduced to 3 days
Initial treatment for a brain infection caused by fungus could now be treated in three days, rather than two weeks, due to study by University of Liverpool scientists.

Contact: Jamie Brown
jamie.brown@liverpool.ac.uk
44-151-794-2248
University of Liverpool

Public Release: 24-Apr-2014
Chemistry & Biology
Large-scale identification and analysis of suppressive drug interactions
Cell analysis finds drug interactions to be startlingly common: baker's yeast is giving scientists a better understanding of drug interactions, which are a major cause of illness and hospitalization worldwide.

Contact: Polly Thompson
pthompson@lunenfeld.ca
416-586-4800 x2046
Lunenfeld-Tanenbaum Research Institute

Public Release: 24-Apr-2014
Blood
Moffitt Cancer Center's phase 3 study may be game-changer for acute myeloid leukemia
Moffitt Cancer Center researchers say clinical trials for a new experimental drug to treat acute myeloid leukemia are very promising. Patients treated with CPX-351, a combination of the chemotherapeutic drugs cytarabine and daunorubicin, are showing better responses than patients treated with the standard drug formulation.
Celator Pharmaceuticals

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 24-Apr-2014
Cell
Genetic legacy from the Ottoman Empire: Single mutation causes rare brain disorder
An international team of researchers have identified a previously unknown neurodegenerative disorder and discovered it is caused by a single mutation in one individual born during the Ottoman Empire in Turkey about 16 generations ago.
NIH/National Human Genome Research Institute, Gregory M. Kiez and Mehmet Kutman Foundation

Contact: Bill Hathaway
william.hathaway@yale.edu
203-432-1322
Yale University

Public Release: 24-Apr-2014
Cell
To mark territory or not to mark territory: Breaking the pheromone code
A team led by scientists at the Scripps Research Institute has deciphered the surprisingly versatile code by which chemical cues help trigger some of the most basic behaviors in mice. The findings shed light on the evolution of mammalian behaviors -- which include human behaviors -- and their underlying brain mechanisms.
National Institutes of Health, Skaggs Foundation, Ellison Medical Foundation, Deutsche Forschungsgemeinschaft, Volkswagen Foundation

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute

Public Release: 24-Apr-2014
Diabetologia
Increasing daily coffee consumption may reduce type 2 diabetes risk
People who increased the amount of coffee they drank each day by more than one cup over a four-year period had a 11 percent lower risk for type 2 diabetes than those who made no changes to their coffee consumption, according to a new study led by Harvard School of Public Health researchers. In addition, the study found that those who decreased their coffee consumption by more than a cup per day increased their type 2 diabetes risk by 17 percent.
National Institutes of Health, American Heart Association, Nestec Ltd.

Contact: Marge Dwyer
mhdwyer@hsph.harvard.edu
617-432-8416
Harvard School of Public Health

Public Release: 24-Apr-2014
Cell
Scientists reprogram blood cells into blood stem cells in mice
Researchers have reprogrammed mature blood cells from mice into blood-forming hematopoietic stem cells, using a cocktail of eight genetic switches called transcription factors. The reprogrammed cells are able to self-renew like HSCs and can give rise to all of the cellular components of the blood like HSCs. The findings mark a significant step toward a major goal of regenerative medicine: the ability to produce HSCs suitable for hematopoietic stem cell transplantation from other cell types.
NIH/National Heart, Lung and Blood Institute, NIH/National Institute of Aging, and others

Contact: Irene Sege
irene.sege@childrens.harvard.edu
617-919-3110
Boston Children's Hospital

Public Release: 24-Apr-2014
Diabetologia
Increasing consumption of coffee is associated with reduced risk of type 2 diabetes
New research published in Diabetologia, the journal of the European Association for the Study of Diabetes, shows that increasing coffee consumption by on average one and half cups per day over a four-year period reduces the risk of type 2 diabetes by 11 percent. The research is led by Dr. Frank Hu and Dr. Shilpa Bhupathiraju, Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, MA, USA, and colleagues.

Contact: Dr. Shilpa Bhupathiraju
sbhupath@hsph.harvard.edu
617-432-8413
Diabetologia

Public Release: 24-Apr-2014
Clinical Infectious Diseases
Pilot study suggests ways to widen access to fecal transplants for C. diff infections
Using frozen stool from healthy, unrelated donors was safe and effective in treating patients with serious, relapsing diarrhea caused by Clostridium difficile, according to a new pilot study published in Clinical Infectious Diseases and available online. Known as fecal microbiota transplantation, the treatment was equally effective whether given via a colonoscope or a nasogastric tube. The findings suggest approaches that may make this promising treatment more readily available to patients.

Contact: Jerica Pitts
jpitts@pcipr.com
312-558-1770
Infectious Diseases Society of America

Public Release: 24-Apr-2014
Circulation: Journal of the American Heart Association
New guidelines aim to improve care for babies with heart problems in the womb
Heart experts have developed the first scientific statement on detecting, managing and treating heart abnormalities in the womb. Medicines, fetal procedures, careful monitoring and strategies for delivery room care are improving the health of babies with heart abnormalities from before birth and beyond. Providers should help families overcome anxiety and depression, so they can transition from grief to acceptance and become active members of the team that cares for their baby.

Contact: Darcy Spitz
darcy.spitz@heart.org
212-878-5940
American Heart Association

Public Release: 24-Apr-2014
Report: Top 12 ways the world can eliminate agriculture's climate footprint
Annual carbon emissions from global agriculture can be reduced by as much as 50 to 90 percent by 2030 -- the equivalent of removing all the cars in the world -- according to a comprehensive new report released by Climate Focus and California Environmental Associates. The study highlights 12 key strategies -- led by reduced global beef consumption, reduced food waste and better farm nutrient management and production -- that can deliver big climate wins while maintaining food security and building resilience.
ClimateFocus, California Environmental Associates

Contact: Susan Tonassi
stonassi@burnesscommunications.com
626-487-9681
Burness Communications

Public Release: 24-Apr-2014
Cell
Researchers discover new genetic brain disorder in humans
A newly identified disorder affecting the human nervous system is caused by a mutation in a gene never before implicated in human disease. By performing DNA sequencing of children affected by neurological problems, two research teams discovered that a disease marked by reduced brain size, as well as sensory and motor defects, is caused by a mutation in a gene called CLP1. Insights into this disorder may have implications for the treatment of common disorders.

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press

Public Release: 24-Apr-2014
PLOS Genetics
Researchers trace HIV adaptation to its human host
'Much research has focused on how HIV adapts to antiviral drugs -- we wanted to investigate how HIV adapts to us, its human host, over time,' says lead author Zabrina Brumme from Simon Fraser University.

Contact: Zabrina Brumme
zbrumme@sfu.ca
PLOS

Public Release: 24-Apr-2014
American Academy of Neurology's 66th Annual Meeting
Study suggests targeting B cells may help with MS
A new study suggests that targeting B cells, which are a type of white blood cell in the immune system, may be associated with reduced disease activity for people with multiple sclerosis. The study is released today and will be presented at the American Academy of Neurology's 66th Annual Meeting in Philadelphia, April 26-May 3, 2014.

Contact: Rachel Seroka
rseroka@aan.com
612-928-6129
American Academy of Neurology