IMAGE: Lung squamous cell carcinoma

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Public Release: 2-Dec-2012
Nature Structural & Molecular Biology
Scientists at Scripps Research Institute discover how 2 proteins help keep cells healthy
Scientists at The Scripps Research Institute have determined how two proteins help create organelles, or specialized subunits within a cell, that play a vital role in maintaining cell health. This discovery opens the door for research on substances that could interfere with the formation of these organelles and lead to new therapies for cancer.
National Institutes of Health, Japan Science and Technology Agency

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute

Public Release: 2-Dec-2012
Nature Genetics
Scientists find 'bully' genes in common childhood tumor
In a genome sequencing study of 74 neuroblastoma tumors in children, scientists at the Johns Hopkins Kimmel Cancer Center and the Children's Hospital of Philadelphia found that patients with changes in two genes, ARID1A and ARID1B, survive only a quarter as long as patients without the changes. The discovery could eventually lead to early identification of patients with aggressive neuroblastomas who may need additional treatments.
NIH/National Cancer Institute, St. Baldrick's Foundation

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 2-Dec-2012
Nature Genetics
Cell surface transporters exploited for cancer drug delivery
According to Whitehead Institute researchers, a protein known as monocarboxylate transporter 1 (MCT1), which is highly expressed in a subset of metabolically altered cancer cells, is needed for the entry of the investigational cancer drug 3-bromopyruvate (3-BrPA) into malignant cells. This work may open a new avenue for cancer therapeutic research, as other transport molecules have already been identified on the surface of certain cancer cells.
National Institutes of Health, David H. Koch Institute for Integrative Cancer Research, Jane Coffin Childs Fund, National Science Foundation

Contact: Nicole Rura
rura@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research

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