IMAGE: Lung squamous cell carcinoma

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Public Release: 3-Sep-2015
Nature Communications
Targeting newly discovered pathway sensitizes tumors to radiation and chemotherapy
In some patients, aggressive cancers can become resistant to chemotherapy and radiation treatments. In a paper published in the journal Nature Communications, University of California, San Diego School of Medicine researchers identified a pathway that causes the resistance and a new therapeutic drug that targets this pathway.
National Institutes of Health, California Breast Cancer Research Foundation IDEA Award and ACS IRG

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 3-Sep-2015
Science
New role for an old protein: Cancer causer
A protein known to play a role in transporting the molecular contents of normal cells into and out of various intracellular compartments can also turn such cells cancerous by stimulating a key growth-control pathway.
National Institutes of Health, Starr Cancer Consortium Award, US Department of Defense

Contact: Matt Fearer
fearer@wi.mit.edu
617-452-4630
Whitehead Institute for Biomedical Research

Public Release: 3-Sep-2015
Journal of Clinical Oncology
Acupuncture reduces hot flashes in breast cancer survivors
Acupuncture may be a viable treatment for women experiencing hot flashes as a result of estrogen-targeting therapies to treat breast cancer, according to a new study. Hot flashes are particularly severe and frequent in breast cancer survivors, but current FDA-approved remedies for these unpleasant episodes, such as hormone replacement therapies are off-limits to breast cancer survivors because they include estrogen. The results of the study are published this week in the Journal of Clinical Oncology.
National Institutes of Health

Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-349-5964
University of Pennsylvania School of Medicine

Latest Multimedia

Japonica Array

Japonica Array
The array contains 659,253 SNPs, including tag SNPs for imputation, SNPs of Y chromosome and mitochondria, and SNPs related to previously reported genome-wide association studies and pharmacogenomics.

Contact: Fuji Nagami
f-nagami@med.tohoku.ac.jp
81-227-177-908
Tohoku University

Form and Function

Form and Function
Comparison of the BRCC36 homodimer (top) with the BRCC36-KIAA0157DC heterodimer (bottom) reveals similarities in MPN domain association but disorder of the helical bundle region.

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Epigenetics and Gain-of-Function p53 Mutations

Epigenetics and Gain-of-Function p53 Mutations
Gain-of-function p53 mutants are recruited by ETS family proteins to activate genes, including key epigenetic enzymes MLL1, MLL2 and MOZ. This, in turn, results in altered histone modifications genome...

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

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