IMAGE: Lung squamous cell carcinoma

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Cancer Cells

Cancer Cells
Cancer cells, left, were pretreated with a drug that blocks the ERK signal, and right, without the pretreatment. Top cells are untreated, while the bottom ones are stimulated.

Contact: Yael Edelman
yael.edelman@weizmann.ac.il
Weizmann Institute of Science

Krebs Cycle, CNIO

Krebs Cycle, CNIO
Mutations (*) in several Krebs cycle genes (IDH1/2, SDH, FH and now MDH2) lead to the accumulation of metabolites (2-HG, SUC and FUM), which cause important changes in gene expression (grey circle).

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Fast Functional Photoacoustic Microscopy

Fast Functional Photoacoustic Microscopy
These images show fast functional photoacoustic microscopy of the mouse brain. Figure (d, left) shows a representative x-y projected brain vasculature image through an intact skull. Figure (e) shows a...

Contact: Julie Flory
julie.flory@wustl.edu
Washington University in St. Louis

New Findings Support the Benefits of Eating Walnuts on Overall Health

New Findings Support the Benefits of Eating Walnuts on Overall Health
Multiple new research abstracts suggest walnuts may have the potential to positively affect several important health factors. From their impact on colon cancer and certain aspects of cognitive aging, ...

Contact: Erin Farkaly
erin.farkaly@edelman.com
415-202-3503
Edelman Seattle

Tomasz Cierpicki and Jolanta Grembecka, University of Michigan

Tomasz Cierpicki and Jolanta Grembecka, University of Michigan
This image shows Tomasz Cierpicki, Ph.D., and Jolanta Grembecka, Ph.D. at the University of Michigan.

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Jolanta Grembecka, University of Michigan

Jolanta Grembecka, University of Michigan
This is Jolanta Grembecka, Ph.D. at the University of Michigan.

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Tomas Cierpicki, University of Michigan

Tomas Cierpicki, University of Michigan
This is Tomasz Cierpicki, Ph.D. at the University of Michigan.

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Researchers Overcome Radiation Resistance in Leukemia With an Engineered Precision Medicine

Researchers Overcome Radiation Resistance in Leukemia With an Engineered Precision Medicine
CD19L-sTRAIL selectively binds to the CD19 receptor on leukemia cells via its CD19L moiety upon which its sTRAIL component kills the cells by engaging the TRAIL death receptors.

Contact: Sacha Boucherie
s.boucherie@elsevier.com
31-204-853-564
Elsevier

Cross Section of a Pubertal Mouse Mammary Duct

Cross Section of a Pubertal Mouse Mammary Duct
Id4+ stem cells are in red, luminal cells in green, and all cells are marked with blue nuclear dye.

Contact: Alison Heather
a.heather@garvan.org.au
61-292-958-128
Garvan Institute of Medical Research

MRI of Healthy Cells Vs. Cancer Cells

MRI of Healthy Cells Vs. Cancer Cells
Normal cells (left) have far more sugar attached to mucin proteins than do cancerous cells (right). Mucin-attached sugar generates a high MRI signal, shown in red.

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine

BHPI and Estrogen Receptor

BHPI and Estrogen Receptor
An experimental drug, BHPI, binds to the estrogen receptor and disrupts the growth of cancer cells.

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign

Stainless Staining

Stainless Staining
Breast tissue is computationally stained using data from infrared imaging without actually staining the tissue, enabling multiple stains on the same sample. From left, the image shows a Hematoxylin ...

Contact: Liz Ahlberg
eahlberg@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign

Molecular Labeling Machine

Molecular Labeling Machine
Scientists found the enzyme METTL3 (green) tags a particular sequence within RNA molecules destined to become gene-regulating microRNAs. While this happens within cells' nuclei (blue), METTL3 is also ...

Contact: Wynne Parry
wparry@rockefeller.edu
212-327-7789
Rockefeller University

Brain Tumor Cells Decimated by Mitochondrial

Brain Tumor Cells Decimated by Mitochondrial
The new drug MP-MUS (yellow) attacks cancer cell mitochondria by infiltrating both inner and outer membranes (green) after being converted from an inactive, non-toxic form to an active, toxic form by ...

Contact: Gale Smith
gsmith@houstonmethodist.org
281-627-0439
Houston Methodist

CK1α: The Achilles Heel of RAS-Driven Cancer Cells

CK1α: The Achilles Heel of RAS-Driven Cancer Cells
Removal of enzyme CK1α blocks cellular digestion in specific cancers.

Contact: Dharshini Subbiah
dharshini.subbiah@duke-nus.edu.sg
659-616-7532
Duke-NUS Graduate Medical School Singapore

Stress Granules Linked to Metastasis

Stress Granules Linked to Metastasis
The time-lapse video shows how the proteins YB-1 (green) and G3BP1 (red) overlap in stress granules, structures whose prevalence in tumors researchers now link to metastasis.

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

Stress Granules in Tumors

Stress Granules in Tumors
Fewer stress granules (yellow) occur in cancer cells lacking G3BP1 (right) than in controls (left). Nuclei are labeled blue.

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

Recruiting Dendritic Cells for Cancer Fight

Recruiting Dendritic Cells for Cancer Fight
This is an artist's representation of the surface of a human dendritic cell.

Contact: Barbara McMakin
nindspressteam@ninds.nih.gov
NIH/National Institute of Neurological Disorders and Stroke

A Urine Test for Kidney Cancer

A Urine Test for Kidney Cancer
Kidney cancer is the seventh most common type of cancer in men and the 10th most common in women, affecting about 65,000 people each year in the united states. Some 14,000 die of the disease each year...

Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine

Bucky-bomb

Bucky-bomb
This is an artist's illustration of a bucky-bomb.

Contact: Robert Perkins
perkinsr@usc.edu
213-740-9226
University of Southern California

Dr. Andrew Brenner, University of Texas Health Science Center at San Antonio

Dr. Andrew Brenner, University of Texas Health Science Center at San Antonio
"I don't like to oversell an unproven drug," Dr. Brenner said, "but I would like to say the laboratory results were very encouraging. I have evaluated a lot of therapeutics and I have not seen this ...

Contact: Elizabeth Allen
allenea@uthscsa.edu
210-450-2020
University of Texas Health Science Center at San Antonio

Culprit in Colon Cancer

Culprit in Colon Cancer
Msi2 (stained red) is broadly expressed in intestinal tumors that result from loss of APC. Penn researchers believe activation of Msi2 downstream of APC loss drives metabolic activation of stem cells ...

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania

Benzopyrene

Benzopyrene
The way in which hazardous organic substances such as benzopyrene get into human cells, their impact and how they are dispersed is another topic that scientists at the UFZ are also investigating ...

Contact: Tilo Arnhold
presse@ufz.de
49-341-235-1635
Helmholtz Centre for Environmental Research - UFZ

Being Obese Can Cause at Least 7 Types of Cancer

Being Obese Can Cause at Least 7 Types of Cancer
According to Cancer Research UK statistics, being obese can cause at least seven types of cancer.

Contact: Emily Head
emily.head@cancer.org.uk
44-203-469-6189
Cancer Research UK

Green Dye Identifies Tumor Blood Vessels

Green Dye Identifies Tumor Blood Vessels
Green dye identifies tumor blood vessels.

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

Cancer Therapy 'Tumor Sanctuaries' and the Breeding Ground of Resistance

Cancer Therapy 'Tumor Sanctuaries' and the Breeding Ground of Resistance
Tissues where tumor growth is fastest are most affected by drugs, whereas tissues where growth is slow may be tumor sanctuaries. It is these sanctuary sites that are the breeding ground of resistance.

Contact: Feng Fu
fufeng@gmail.com
41-446-329-303
PLOS

Androgen Receptor Structure

Androgen Receptor Structure
In red is the domain of the androgen receptor protein where drugs to treat prostate cancer bind. In blue and black, parts of the protein where it might be feasible to direct new drugs.

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)

Brain Tumor Stem Cells

Brain Tumor Stem Cells
Brain tumor stem cells (orange) in mice express a stem cell marker (green). Researchers at Washington University School of Medicine in St. Louis are studying how cancer stem cells make tumors harder ...

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine

Ras-induced Senescence

Ras-induced Senescence
Activated Ras induces cell senescence (blue) are shown in the presence (left), but not the absence (right), of NORE1A.

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

Playing with Size -- a Range of Florida Carpenter Ants

Playing with Size -- a Range of Florida Carpenter Ants
McGill researchers have discovered that environmental factors play a crucial role in determining complex traits like size

Contact: Katherine Gombay
katherine.gombay@mcgill.ca
McGill University

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