IMAGE: Lung squamous cell carcinoma

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Turning the Tables

Turning the Tables
Turning the tables, Katherine Borden at the University of Montreal's Institute for Research in Immunology and Cancer (IRIC) has evoked Star Trek's Borg in her fight against the disease. "Cancer cells ...

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal

Star Trek's Borg Evoked

Star Trek's Borg Evoked
Turning the tables, Katherine Borden at the University of Montreal's Institute for Research in Immunology and Cancer (IRIC) has evoked Star Trek's Borg in her fight against the disease. "Cancer cells ...

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal

3BrPA (red)

3BrPA (red)
3BrPA (red) is illustrated encased in a sugar-based microshell.

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

MCF-7 Cells

MCF-7 Cells
Pictured are MCF-7 human breast cancer cells, stably transformed with SNAIL (right) or an empty vector control (left). Cells expressing SNAIL show an increased mesenchymal phenotype and malignant ...

Contact: Brett Israel
brett.israel@comm.gatech.edu
404-385-1933
Georgia Institute of Technology

Synthetic Molecules that Mimic Antibodies

Synthetic Molecules that Mimic Antibodies
SyAMs recognize disease cells and bind with a specific protein on their surface. They also bind with a receptor on an immune cell.

Contact: Jim Shelton
james.shelton@yale.edu
203-432-3881
Yale University

Direct Reprogramming

Direct Reprogramming
Dermal fibroblasts are directly reprogrammed to pigmented melanocytes by three transcription factors (SOX10, MITF and PAX3).

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Comparison between the Normal Cervical Tissue and Tissue Lesion for Different Stages

Comparison between the Normal Cervical Tissue and Tissue Lesion for Different Stages
This shows a comparison between the normal cervical tissue and tissue lesion for different stages. From top to bottom are the pathological images for the normal cervical tissue (first row) and tissue ...

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
The Optical Society

Hydrogel Activation

Hydrogel Activation
A hydrogel with a cross-linked fluorescent group that had been caged with a molecular 'hat' was irradiated with UV light to remove the caging group and activate fluorescence. The patterning is ...

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology

Light-Activated Peptide

Light-Activated Peptide
Researchers have developed a technique for activating biological signals through the skin of a living animal using light. In this illustration, ultraviolet light is shining through a pattern, ...

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology

Red, Green and Blue Outputs Provided by Fluorescent Proteins

Red, Green and Blue Outputs Provided by Fluorescent Proteins
UMass Amherst chemists have devised a multi-channel signature-based approach to screening drugs using a gold nanoparticles with red, green and blue outputs provided by fluorescent proteins.

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst

Bacteria Forming a Mixed Biofilm on Colon Cancer Tissue

Bacteria Forming a Mixed Biofilm on Colon Cancer Tissue
Bacteria forms a mixed biofilm on colon cancer tissue.

Contact: Diana Kenney
dkenney@mbl.edu
508-289-7139
Marine Biological Laboratory

Genetic Cancer Connections

Genetic Cancer Connections
An algorithm called HotNet2 helps define the terrain for complex genetic associations involved in cancer. 'The next step,' says researcher Ben Raphael, 'is translating all of this information from ...

Contact: Kevin Stacey
kevin_stacey@brown.edu
401-863-3766
Brown University

Microwave Imaging of the Breast

Microwave Imaging of the Breast
These are internal, spatially mapped microwave tomography system generated electrical property distribution images of a cancer patient's left breast, taken somewhat into her therapy. Shown are ...

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
American Institute of Physics

Microwave Breast Imager

Microwave Breast Imager
This image shows an image of a microwave breast tomography instrument.

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
American Institute of Physics

Follicle Progenitors

Follicle Progenitors
Fruit fly ovarian follicle progenitor cells, with different colors marking a specific kind of activity (red) specific gene expression (green) and nuclear DNA (blue).

Contact: Allan Spradling
spradling@ciwemb.edu
Carnegie Institution

New Breast Cancer Classification Based on Epigenetics

New Breast Cancer Classification Based on Epigenetics
This is an image of a breast tumor identified as Epi-Luminal B of poor prognosis.

Contact: Arantxa Mena
amena@idibell.cat
0034-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute

A Potential Battery Terminal?

A Potential Battery Terminal?
This image shows the complex multiscale structure of a carbonized mouse spleen.

Contact: Neal Singer
nsinger@sandia.gov
505-845-7078
DOE/Sandia National Laboratories

DNA Double-Strand Break by the Endonuclease I-DmoI

DNA Double-Strand Break by the Endonuclease I-DmoI
The video illustrates how the I-DmoI endonuclease nicks the phosphodiester bonds that maintain the structural backbone of the DNA. Based on the initial state (State 1), we can observe: two consecutive...

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Enzyme I-DmoI

Enzyme I-DmoI
The enzyme I-DmoI (purple) is specifically associated to the double strand of DNA (yellow and green).

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Young and Old Cells Exposed to Fluorescent Antibodies

Young and Old Cells Exposed to Fluorescent Antibodies
Young and old cells exposed to fluorescent antibodies against the novel markers. Old cells can be easily identified because they shine bright under the microscope.

Contact: Salvador Macip
sm460@le.ac.uk
University of Leicester

Molecular Signal Helps Cancer Cells Dodge Death

Molecular Signal Helps Cancer Cells Dodge Death
A cell's ability to divide in two is fundamental to life. These white blobs show DNA being separated as cells divide. But if mistakes are made, this can lead to genetic errors, and cancer.

Contact: Stephanie McClellan
stephanie.mcclellan@cancer.org.uk
44-203-469-5314
Cancer Research UK

Cancer Cells

Cancer Cells
The image shows cancer cells where the number of chromosomes in each nucleus is not as it should be -- a condition known as "aneuploidy." The green spots show a marker for the chromosomes, and the red...

Contact: Stephanie McClellan
stephanie.mcclellan@cancer.org.uk
44-203-469-5314
Cancer Research UK

Walton's Mushrooms

Walton's Mushrooms
A team of Michigan State University scientists has discovered an enzyme that is the key to the lethal potency of poisonous mushrooms.

Contact: Layne Cameron
layne.cameron@cabs.msu.edu
517-353-8819
Michigan State University

Many Neurons Expressing Topoisomerase-1

Many Neurons Expressing Topoisomerase-1
THis image shows neurons from a mouse expressing the gene Topoisomerase-1, in white.

Contact: Mark Derewicz
mark.derewicz@unchealth.unc.edu
919-923-0959
University of North Carolina Health Care

Neurons Expressing Topoisomerase-1

Neurons Expressing Topoisomerase-1
This image shows neurons expressing the Topoisomerase-1 gene, in green.

Contact: Mark Derewicz
mark.derewicz@unchealth.unc.edu
919-923-0959
University of North Carolina Health Care

Dual Function of TRBP

Dual Function of TRBP
By analyzing cells with genetic deletion of TRBP, the research team revealed cell cycle dependent regulation of PKR by TRBP and evaluated the function of TRBP in microRNA biogenesis.

Contact: Hanbin Oh
ohanvin@ibs.re.kr
82-428-788-182
Institute for Basic Science

Activation of PKR by dsRNAs During Mitosis

Activation of PKR by dsRNAs During Mitosis
When cells are undergoing division, intermixing of cellular compartments allow dsRNAs and PKR to interact, leading to activation of PKR. When activated, PKR regulates protein synthesis and mitotic ...

Contact: Hanbin Oh
ohanvin@ibs.re.kr
82-428-788-182
Institute for Basic Science

Transforming Cancer Research: The Genomic Data Commons

Transforming Cancer Research: The Genomic Data Commons
The establishment of the NCI Genomic Data Commons will expand access for scientists around the country, speeding up research and, in turn, leading to faster discoveries for patients. The GDC will ...

Contact: Kevin Jiang
kevin.jiang@uchospitals.edu
773-795-5227
University of Chicago Medical Center

Approved Drug Tamoxifen, Molecular Weapon to Treat Blood Neoplasms

Approved Drug Tamoxifen, Molecular Weapon to Treat Blood Neoplasms
This study suggests that the blood stem cells (pink for female, blue for male) that, when altered, produce excessive blood cells (diseases called neoplasms) can be killed by female sex hormones. This ...

Contact: Ainhoa Iriberri
airiberri@cnic.es
34-610-295-556
Centro Nacional de Investigaciones Cardiovasculares

Graphical Abstract of Study

Graphical Abstract of Study
This is a graphic of the study. This discovery has a potential application in the treatment of certain blood disorders for which there is currently no cure.

Contact: Ainhoa Iriberri
airiberri@cnic.es
34-610-295-556
Centro Nacional de Investigaciones Cardiovasculares

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