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Cancer Drug Tested in Pet Dogs Begins Human Trials

Cancer Drug Tested in Pet Dogs Begins Human Trials
A new anti-cancer compound, PAC-1, spurs cell death in cancer cells while sparing healthy cells.

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign

Tissue of the Fruit Fly

Tissue of the Fruit Fly
Tissue of the fruit fly, where magenta marks the cell's skeleton, and green marks an area where Zyxin protein is inducing cell multiplication.

Contact: Ana Mena
anamena@igc.gulbenkian.pt
351-214-407-959
Instituto Gulbenkian de Ciencia

Disparities in Breast Cancer Care Linked to Net Worth

Disparities in Breast Cancer Care Linked to Net Worth
Household net worth more important than income in gauging patient's ability to afford treatment.

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center

A Cue for Cancer

A Cue for Cancer
To see how the growth signal TGF-beta influences cancer cells, the researchers used a red tag (top) to mark mouse tumor stem cells that received the signal, and a green tag (bottom) to track ...

Contact: Wynne Parry
wparry@rockefeller.edu
212-327-7789
Rockefeller University

Organoids (2 of 2)

Organoids (2 of 2)
This is a patient derived tumor organoids. Blue: nuclei; red: membrane.

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)

Colon Tumor

Colon Tumor
This is a microscopy image of a colon tumor.

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)

Organoids (1 of 2)

Organoids (1 of 2)
This is a patient-derived tumor organoids: in vitro expansion.

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)

Cryptophycin

Cryptophycin
The researchers want to 'package' the anti-tumor agent cryptophycin in such a way that it only targets cancer cells. The image shows how cryptophycin binds to a protein molecule, as also occurs in ...

Contact: Norbert Sewald
norbert.sewald@uni-bielefeld.de
49-052-110-62051
Bielefeld University

Illustration of the Fluorescent Cross-Responsive Sensor Array Device (2 of 2)

Illustration of the Fluorescent Cross-Responsive Sensor Array Device (2 of 2)
This illustration shows the structure of the rotary type reaction chamber.

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
American Institute of Physics

Illustration of the Fluorescent Cross-Responsive Sensor Array Device (1 of 2)

Illustration of the Fluorescent Cross-Responsive Sensor Array Device (1 of 2)
The fluorescent cross-responsive sensor array that consists of 35 chemically responsive spots and three through holes for zero point positioning.

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
American Institute of Physics

Octahedral Cage of the Catalyst

Octahedral Cage of the Catalyst
Four resorcinol molecules are linked to form a large ring consisting of 16 carbon atoms. Six of these molecules self-assemble in solution to an octahedron-like cage. The electron-rich aromatic ring ...

Contact: Dr. Andreas Battenberg
battenberg@zv.tum.de
49-892-891-0510
Technische Universitaet Muenchen

Epigenomic Signature

Epigenomic Signature
Researchers hypothesized that variation in the 'mutational landscape' might be influenced by chromatin structure, or the way that DNA is packaged, which varies widely from cell type to cell type.

Contact: Haley Bridger
hbridger@partners.org
617-525-6383
Brigham and Women's Hospital

Peptide Backbone

Peptide Backbone
The P99 beta lactamase peptide backbone is shown in complex with a beta lactam substrate (PDB file 4KEN), which is rendered as a stick figure with carbon in cyan, nitrogen in dark blue, oxygen in red...

Contact: Kirk Cassels
kirk.A.Cassels@Hitchcock.org
603-653-6177
The Geisel School of Medicine at Dartmouth

Prostate Tumors

Prostate Tumors
A near-infrared dye targets tumors in a mouse.

Contact: Robert Perkins
perkinsr@usc.edu
213-740-9226
University of Southern California

Probe

Probe
This is a Raman spectroscopy probe.

Contact: Anita Kar
anita.kar@mcgill.ca
514-398-3376
McGill University

Zooming into Cancer Cells

Zooming into Cancer Cells
The probe allows surgeons to see very small densities of cancer cells in the brain during surgery.

Contact: Anita Kar
anita.kar@mcgill.ca
514-398-3376
McGill University

Study Finds New Lethal Combination of Cancer Drugs Shrinks Tumors

Study Finds New Lethal Combination of Cancer Drugs Shrinks Tumors
This image depicts drug-tolerant cells. Nuclear translocation of HCK drives anti-apoptotic signaling in response to taxane chemotherapy. This process is initiated by phenotypic plasticity coordinated ...

Contact: Nick Manning
nmanning@uwaterloo.ca
226-929-7627
University of Waterloo

AngioVac Procedure

AngioVac Procedure
This is a diagram showing how the cancer patient's tumor was suctioned from the vein to allow for minimally invasive kidney surgery.

Contact: Dwight Angell
Dwight.Angell@hfhs.org
313-876-8709
Henry Ford Health System

First in Man: Tumor Suctioned From Vein to Allow Minimally Invasive Kidney Surgery

First in Man: Tumor Suctioned From Vein to Allow Minimally Invasive Kidney Surgery
Physicians at Henry Ford Hospital successfully suctioned a cancerous tumor from a major vein in a patient with metastatic kidney cancer, clearing the way for him to undergo a minimally-invasive kidney...

Contact: Dwight Angell
Dwight.Angell@hfhs.org
313-876-8709
Henry Ford Health System

Franziska Michor: Winner of the 2015 Vilcek Prize for Creative Promise in Biomedical Science

Franziska Michor: Winner of the 2015 Vilcek Prize for Creative Promise in Biomedical Science
Franziska Michor was picked as the winner of a Creative Promise Prize in Biomedical Science for her research that fuses evolutionary biology, mathematics, and clinical research toward a better ...

Contact: Phuong Pham
phuong@vilcek.org
212-472-2500
Vilcek Foundation

Mini Lecture: Cancer

Mini Lecture: Cancer

What exactly IS cancer? And how can we fight it? This educational Mini Lecture explains playfully how cancer originates in the human body, how it affects health and which research paths may lead to...

Contact: Christian Schumacher
christian.schumacher@lindau-nobel.org
49-083-822-773-115
Lindau Nobel Laureate Meetings

Confocal Microscopy Image

Confocal Microscopy Image
This confocal microscopy image depicts drug-tolerant cancer cells. By hitting breast cancer cells with a targeted therapeutic immediately after chemotherapy, researchers were able to target cancer ...

Contact: Haley Bridger
hbridger@partners.org
617-525-6383
Brigham and Women's Hospital

A Single Well of the 3-D HTS Tool

A Single Well of the 3-D HTS Tool
Green indicates cancer cells bound to tissue in a single well.

Contact: John Easton
John.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center

3-D Organotypic HTS Assay

3-D Organotypic HTS Assay
This is a multi-layered 3-D 'organotypic' platform for quantitative high-throughput screening to identify new therapeutics for ovarian cancer. Fibroblasts are red. Mesothelial cells are blue. Ovarian ...

Contact: John Easton
John.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center

A 384-well HTS Platform

A 384-well HTS Platform
This image shows a signal in a 384-well HTS assay. Green indicates more cancer cells bound to tissue. Black means fewer cancer cells bound, showing that the compound tested in that well inhibited ...

Contact: John Easton
John.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center

Could There Be a Gleevec for Brain Cancer?

Could There Be a Gleevec for Brain Cancer?
This image shows fusion protein (red) in tumor cells from a histological section of human glioblastoma.

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center

NHE9 Causes Alkaline Endosomes in Certain Brain Cancers

NHE9 Causes Alkaline Endosomes in Certain Brain Cancers
The 'cargo carriers,' or endosomes, of certain brain cancer cells contain overactive NHE9 proteins (blue), which pump out too many protons (orange), changing the endosomes' acidity and slowing their '...

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine

The Increase in the Extent of Tissue Ablation Achieved by Combining Reversible Electroporation Pulse

The Increase in the Extent of Tissue Ablation Achieved by Combining Reversible Electroporation Pulse
The increase in the extent of tissue ablation achieved by combining reversible electroporation pulses withelectrolysis is shown with Masson's trichromatic staining of the liver tissue. Plate ...

Contact: Philly Lim
mllim@wspc.com.sg
65-646-65775
World Scientific

CNIO Grid of Proteins

CNIO Grid of Proteins
This is a grid of proteins conferring aggressiveness in CLL (in consistence with the study).

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Mouse Brain

Mouse Brain
This image shows the detail of one millimeter of a mouse brain. In green, capillaries that form part of the blood-brain barrier; in red, molecules attached to the shuttle patented by IRB Barcelona ...

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)

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