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Quantitating the Complete Human Proteome

Quantitating the Complete Human Proteome
This is an illustration of SRM peaks and a human face.

Contact: Hsiao-Ching Chou
hchou@systemsbiology.org
206-732-2157
Institute for Systems Biology

Regenstrief Institute investigator Thomas F. Imperiale, M.D., Indiana University

Regenstrief Institute investigator Thomas F. Imperiale, M.D., Indiana University
Thomas F. Imperiale, M.D. is a VA, Regenstrief Institute, and Indiana University clinician-researcher.

Contact: Cindy Fox Aisen
caisen@iupui.edu
317-843-2275
Indiana University

Drugs Deliver One-Two Punch Against Resistant Kidney Cancer

Drugs Deliver One-Two Punch Against Resistant Kidney Cancer
Researchers report that a combination of standard chemotherapy and an epigenetic drug may overcome drug resistance in kidney cancer. This material relates to a paper that appeared in the July 20. 2016...

Contact: Science Press Package
scipak@aaas.org
202-326-6440
American Association for the Advancement of Science

Gene Therapy Staves Off Cancer-Driven Muscle Wasting (2 of 2)

Gene Therapy Staves Off Cancer-Driven Muscle Wasting (2 of 2)
Smad7 gene delivery promotes skeletal muscle hypertrophy in healthy mice. This material relates to a paper that appeared in the July 20, 2016, issue of Science Translational Medicine, ...

Contact: Science Press Package
scipak@aaas.org
202-326-6440
American Association for the Advancement of Science

Gene Therapy Staves Off Cancer-Driven Muscle Wasting (1 of 2)

Gene Therapy Staves Off Cancer-Driven Muscle Wasting (1 of 2)
Muscle-directed gene therapy may protect against muscle wasting associated with advanced cancer, researchers show in mice. This material relates to a paper that appeared in the July 20, 2016, issue of...

Contact: Science Press Package
scipak@aaas.org
202-326-6440
American Association for the Advancement of Science

Fatty Tissue May Be 'Robbers Cave' for Cancer Stem Cells

Fatty Tissue May Be 'Robbers Cave' for Cancer Stem Cells
Study shows that cancer stem cells may hide in fatty tissue, even transforming this tissue to help them resist chemotherapy.

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Anschutz Medical Campus

Silicon Nanoparticles

Silicon Nanoparticles
Left: Schematic representation of silicon nanoparticles (SiNPs) biodegradation processes: (I) localization of SiNPs on the cell membrane; (II) penetration of SiNPs in the cytoplasm with partial ...

Contact: Vladimir Koryagin
science-release@rector.msu.ru
Lomonosov Moscow State University

Synthetic Cell Wiring

Synthetic Cell Wiring
This image represents synthetic lethal wiring of a cancer cell, with previously known interactions in red and newly discovered interactions in gray.

Contact: Heather Buschman
hbuschman@ucsd.edu
858-249-0456
University of California - San Diego

Theresa A. Keresztes, 2016 ASTRO Survivor Circle Award Winner

Theresa A. Keresztes, 2016 ASTRO Survivor Circle Award Winner
Theresa A. Keresztes, 2016 ASTRO Survivor Circle Award Winner

Contact: Erin L. Boyle
erin.boyle@astro.org
703-839-7336
American Society for Radiation Oncology

Functional Units

Functional Units
In the new algorithm, proteins are denoted in a radial-spherical coordinate system, which itself is as close as possible to the shape of the protein. This allows the proteins to be split into "...

Contact: Sergey Divakov
divakov@phystech.edu
Moscow Institute of Physics and Technology

Protein Complex

Protein Complex
The actual structure of a protein complex together with an ensemble of alternative structures selected using the new algorithm.

Contact: Sergey Divakov
divakov@phystech.edu
Moscow Institute of Physics and Technology

Thyroid Cancer

Thyroid Cancer
More imaging after thyroid cancer treatment identifies recurrence, but it does not always improve survival, a new study suggests. Megan Haymart, M.D., and Mousumi Banerjee, Ph.D., discuss.

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Ocean Bacteria

Ocean Bacteria
Marine bacteria Vibrio alginolyticus magnified several thousand times.

Contact: Catriona Kelly
Catriona.Kelly@ed.ac.uk
44-131-651-4401
University of Edinburgh

Turning on T Cells

Turning on T Cells
Researchers imaged cells to identify proteins that affect the expression of a genetic switch for T cells. On the right, T cells where the switch is activated glow in yellow. On the left, the rainbow ...

Contact: Whitney Clavin
wclavin@caltech.edu
626-395-1856
California Institute of Technology

New Structure of a Calcium-Shuttling Molecule Could Help Scientists Target Aggressive Cancers

New Structure of a Calcium-Shuttling Molecule Could Help Scientists Target Aggressive Cancers
Scientists have captured new images of a calcium-shuttling molecule that has been linked to aggressive cancers. The three-dimensional structure could help researchers develop novel therapies and ...

Contact: Lucky Tran
lucky.tran@columbia.edu
212-305-3689
Columbia University Medical Center

New Mass Spectrometry Imaging

New Mass Spectrometry Imaging
A new mass spectrometry imaging protocol allows the analysis of metabolites like Adenosine monophosphate from FFPE tissue, shown here as background.

Contact: Dr. Axel Karl Walch
axel.walch@helmholtz-muenchen.de
49-893-187-2739
Helmholtz Zentrum München - German Research Center for Environmental Health

Contacts with Endoplasmic Reticulum Regulate DNA Synthesis, Division of Mitochondria

Contacts with Endoplasmic Reticulum Regulate DNA Synthesis, Division of Mitochondria
Mitochondria play a vital role in cell health and disease and have their own DNA. New UC Davis research shows that mitochondrial DNA (green spots) is found at points where mitochondria (blue) are in ...

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis

Enzyme Structure

Enzyme Structure
Panel a: This is a cartoon "ribbon" diagram of the structure of Rumi in complex with the donor substrate UDP-Glucose (UDP-Glc, shown in cyan) and acceptor substrate hFA9 EGF (dark green). ...

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory

Melanoma

Melanoma
The left two columns show resolution of skin lesion samples taken with two conventional types of deep-tissue microscopy. The right column contains images taken with a pump-probe microscope, showing ...

Contact: Anne Ju Manning
anne.manning@colostate.edu
970-491-7099
Colorado State University

Visualization

Visualization
This is a visualization of the coronary vasculature patterning of an adult mouse heart.

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

PET/MRI Comparison Images of Prostate Cancer

PET/MRI Comparison Images of Prostate Cancer
The figure shows a Gleason 3+4 prostate cancer (arrows) as identified on T2-weighted (A) and diffusion-weighted (B) MRI, F-18-choline PET (C), as well as PET/MRI (D).

Contact: Laurie Callahan
lcallahan@snmmi.org
Society of Nuclear Medicine

Dr. John Dick, Senior Scientist, Princess Margaret Cancer Centre

Dr. John Dick, Senior Scientist, Princess Margaret Cancer Centre
International stem cell scientists, co-led in Canada by Dr. John Dick, have discovered the switch to harness the power of cord blood and potentially increase the supply of stem cells for cancer ...

Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network

Schematic View of Biglycan's Role in Metastasis

Schematic View of Biglycan's Role in Metastasis
Tumor endothelial cells (TEC) affected by the tumor microenvironment express biglycan, which allows tumor cells to break through the gate and proceed into bloodstream.

Contact: Naoki Namba
pr@oia.hokudai.ac.jp
81-117-068-034
Hokkaido University

The Secretion of Biglycan in Tumor Blood Vessels of Cancer Patients

The Secretion of Biglycan in Tumor Blood Vessels of Cancer Patients
A strong biglycan signal (red) was detected in the tumor blood vessel area of a metastatic case (right) but was barely detected in the tumor tissues of a non-metastatic case (left).

Contact: Naoki Namba
pr@oia.hokudai.ac.jp
81-117-068-034
Hokkaido University

Scalpel-Free Brain Surgery Approved for Patients with Most Common Movement Disorder

Scalpel-Free Brain Surgery Approved for Patients with Most Common Movement Disorder
In this compelling video, Dr. Jeff Elias, M.D., of the UVA School of Medicine, discusses the scalpel-free approach to brain surgery that has just been approved for treating essential tremor, the most ...

Contact: Josh Barney
jdb9a@virginia.edu
434-906-8864
University of Virginia Health System

Fat Cells

Fat Cells
Fat cells cultured from the body mass index of a morbidly obese patient cause multiple myeloma cells to anchor to a much greater extent than normal cells and produce a significantly larger number of ...

Contact: Rebecca Basu
basu@american.edu
202-885-5950
American University

Budding Yeast Cells

Budding Yeast Cells
Budding yeast added new noncoding introns in their genome.

Contact: Kristin Phillips
kristin.phillips@austin.utexas.edu
512-232-0654
University of Texas at Austin

Tumor DNA Foretells Relapse in Colon Cancer Patients

Tumor DNA Foretells Relapse in Colon Cancer Patients
A new study suggests that circulating tumor DNA in the blood can predict the risk of relapse in patients with stage II colon cancer. This material relates to a paper that appeared in the July 06, 2016...

Contact: Science Press Package Team
scipak@aaas.org
202-346-6440
American Association for the Advancement of Science

VATS Surgery for Lung Cancer

VATS Surgery for Lung Cancer
Dr. Moishe Liberman is performing VATS surgery for lung cancer.

Contact: Isabelle Girard
isabelle.girard.chum@ssss.gouv.qc.ca
51-489-080-001-272
University of Montreal Hospital Research Centre (CRCHUM)

Space Suit Art Project

Space Suit Art Project
Space Suit Art Project is shown.

Contact: Katrina Burton
kburton@mdanderson.org
713-792-8034
University of Texas M. D. Anderson Cancer Center

Local Drug Activation at Solid Tumor Sites

Local Drug Activation at Solid Tumor Sites
A polymer material (blue) targets drug activation of doxorubicin (red) to sarcoma tumors, minimizing toxicity because the drug is shielded while in the blood (green).

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

Epigenome

Epigenome
This is an example of an epigenome derived from a tumor sample included in study. Green fluorescence signals indicate a loss of epigenetic signal, while red indicates a gain of epigenetic signal.

Contact: Gemma Fornons
gfornons@idibell.cat
0034-638-685-074
IDIBELL-Bellvitge Biomedical Research Institute

Melanoma

Melanoma
A new study finds that melanoma screening by primary care providers did not lead to a potentially problematic spike in dermatologist visits or skin surgeries.

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

Let-7 and Neuroblastoma Survival

Let-7 and Neuroblastoma Survival
These survival curves, based on 202 patients with neuroblastoma, show that chromosomal let-7 loss reduces survival in both MYCN-amplified and non-MYCN-amplified neuroblastoma. With a larger patient ...

Contact: Keri Stedman
keri.stedman@childrens.harvard.edu
617-919-3110
Boston Children's Hospital

Two Ways Neuroblastoma Takes out let-7

Two Ways Neuroblastoma Takes out let-7
This Venn diagram shows that most patients with neuroblastoma lose let-7 through a single mechanism, but rarely both together. In about 25 percent of patients, the oncogene MYCN is amplified, whereas ...

Contact: Keri Stedman
keri.stedman@childrens.harvard.edu
617-919-3110
Boston Children's Hospital

Basal Cell Carcinoma

Basal Cell Carcinoma
The green-labelled cells show a basal cell carcinoma in mouse tail epidermis derived from a single mutant stem cell and expanding out of the normal epidermis stained in red.

Contact: Craig Brierley
craig.brierley@admin.cam.ac.uk
44-012-237-66205
University of Cambridge

Gene Silencing at Breast Cancer Cells

Gene Silencing at Breast Cancer Cells
Immunofluorescent breast cancer cells used in this study. Green fluorescent shows the phosphorylated progesterone receptor at Serine 294 and red fluorescent signal shows the same progesterone receptor...

Contact: Laia Cendros
laia.cendros@crg.eu
34-607-611-798
Center for Genomic Regulation

In the Absence of Disabled-2 , Vps34/Beclin-1 Interactions are Maintained

In the Absence of Disabled-2 , Vps34/Beclin-1 Interactions are Maintained
Immunofluorescence analysis to detect the expression and localization of Vps34 and Beclin-1 in cathepsin B overexpressing mouse mammary epithelial (CTSB/OE cells) treated -/+ TGF-beta? for 7 days. ...

Contact: Heather Woolwine
woolwinh@musc.edu
843-792-7669
Medical University of South Carolina

Electric Therapy

Electric Therapy
This is a photo of three microfluidic devices filled with food color dyes. The device, about the size of a credit card, is designed to help scientists narrow in on safe ranges of electric fields that ...

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology

Going to 'Wars' against Cancer and Heart Disease

Going to 'Wars' against Cancer and Heart Disease
This is a microscopic view to show blood vessel formation or angiogenesis at high resolution. Left: Normal blood vessel formation throughout the body during development of a zebrafish embryo. Right: ...

Contact: Yen May Ong
yenmay.ong@duke-nus.edu.sg
65-660-12057
Duke-NUS Medical School

Mitochondria Stress and Cancer

Mitochondria Stress and Cancer
Mitochondrial stress induces expression of nearly 120 genes involved in cell metabolism, morphology, resistance to apoptosis and cell invasion in addition upregulation of p53 by reduced expression of ...

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania

Cancer Pathway Activated from 'Below'

Cancer Pathway Activated from 'Below'
FER activates a receptor called MET from below, i.e., in the absence of a growth factor like HGF docking at the receptor surface. MET is often overexpressed in aggressive ovarian cancers. Drs. Fan and...

Contact: Peter Tarr
tarr@cshl.edu
516-367-5055
Cold Spring Harbor Laboratory

Supressing FER Reduces Metastasis

Supressing FER Reduces Metastasis
Experiments in mice showed that FER helps to promote metastasis in ovarian cancer. Three mice with similar primary ovarian tumors are shown prior to surgery (top row) and following surgery (middle and...

Contact: Peter Tarr
tarr@cshl.edu
516-367-5055
Cold Spring Harbor Laboratory

A New Pathway in Ovarian Cancer

A New Pathway in Ovarian Cancer
A previously undiscovered pathway through which ovarian cells can be transformed into cancer cells. The key is a protein called FER, which can be found floating in the cell cytoplasm. CSHL scientists ...

Contact: Peter Tarr
tarr@cshl.edu
516-367-5055
Cold Spring Harbor Laboratory

Subtle Changes in Benign Tissues

Subtle Changes in Benign Tissues
In benign tissue next to a prostate tumor, the orientation of prostate glands, tends to be more uniform in those at low risk for biomedical recurrence but disordered among those at high risk.

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-534-7183
Case Western Reserve University

Swappable Binding Sites Reveal a Drug's Target

Swappable Binding Sites Reveal a Drug's Target

(top) This image shows Boehringer Ingelheim generated molecules that inhibit the BRD9 bromodomain. The middle molecule, BI-7273, was selected as the best of the three and was used in experiments ...

Contact: Peter Tarr
tarr@cshl.edu
516-367-5055
Cold Spring Harbor Laboratory

Where a New Drug Binds to Prevent Leukemia from Proliferating

Where a New Drug Binds to Prevent Leukemia from Proliferating
View at atomic resolution shows how candidate drug BI-7273 fits precisely in BRD9's deep bromodomain binding pocket. In preclinical tests, the drug's binding prevented AML cells from proliferating.

Contact: Peter Tarr
tarr@cshl.edu
516-367-5055
Cold Spring Harbor Laboratory

Computer Detection Vs Expert Detection of Early Esophageal Cancer

Computer Detection Vs Expert Detection of Early Esophageal Cancer
Six contours were drawn by five experts and the computer systems, of early esophageal cancer. The image top right is the contour drawn by the computer system.

Contact: Fons van der Sommen
f.v.d.sommen@tue.nl
31-652-457-838
Eindhoven University of Technology

Pharmacogenomic Interactions in Cancer

Pharmacogenomic Interactions in Cancer
A discovery that cancer cell lines can be used to predict how a tumor is likely to respond to a drug has implications for developing new, personalized treatments.

Contact: Mary Todd Bergman
mary@ebi.ac.uk
44-788-137-7941
European Molecular Biology Laboratory - European Bioinformatics Institute

Alejandro Granados, Imperial College London

Alejandro Granados, Imperial College London
Dr Alejandro Granados from Imperial College London demonstrates the robotic rectum technology, which he has developed to enable medics to practise rectal exams.

Contact: kate wighton
k.wighton@imperial.ac.uk
44-020-759-42410
Imperial College London

Robotic Rectum Technology Developed by Imperial College London

Robotic Rectum Technology Developed by Imperial College London
Dr Alejandro Granados from Imperial College London demonstrates the robotic rectum technology, which he has developed to enable medics to practise rectal exams.

Contact: kate wighton
k.wighton@imperial.ac.uk
44-020-759-42410
Imperial College London

Alejandro Granados, Imperial College London

Alejandro Granados, Imperial College London
Dr Alejandro Granados from Imperial College London demonstrates the robotic rectum technology, which he has developed to enable medics to practise rectal exams

Contact: kate wighton
k.wighton@imperial.ac.uk
44-020-759-42410
Imperial College London

<i>Telmatosaurus</i> Reconstruction

Telmatosaurus Reconstruction
This is a reconstruction of the young, deformed Telmatosaurus individual, with the ameloblastoma just becoming visible on its lower left jaw.

Contact: Media Relations
press@soton.ac.uk
0238-059-3212
University of Southampton

Study: Teaching Cancer Patients to Tango Boosts Balance

Study: Teaching Cancer Patients to Tango Boosts Balance
Effects of chemo can impact balance, tango classes cut risk of falls by 56%

Contact: Kelly Stincer
kelly@mediasourcetv.com
614-932-9950
MediaSource

Tango Helping Cancer Survivors Regain Balance

Tango Helping Cancer Survivors Regain Balance
Former cancer patient Tim Hickey dances the Argentine tango with Mimi Lamantia at The Ohio State University. With just a five weeks of dance lessons, participants improved their balance by 56 percent...

Contact: Kelly Stincer
kelly@mediasourcetv.com
614-932-9950
MediaSource

Cancer Survivors Rebuild Strength and Balance with Tango

Cancer Survivors Rebuild Strength and Balance with Tango
Tim Hickey dances the Argentine tango with Mimi Lamantia to build strength and balance after surviving cancer. Like many patients, Hickey suffered from peripheral neuropathy, which can occur when ...

Contact: Kelly Stincer
kelly@mediasourcetv.com
614-932-9950
MediaSource

Samples

Samples
These are liquid biopsy samples.

Contact: Amy Mone
amone@jhmi.edu
410-614-2915
Johns Hopkins Medicine

mTorc1

mTorc1
Two daughter cells of a T-cell. The blue dye shows the nucleus; the green dye shows the CD 8 protein, an immune cell marker; the red dye shows the amount of the mTORC1 enzyme in each cell; the purple ...

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Signaling Cascade for STAT3 Activation

Signaling Cascade for STAT3 Activation
ARL3 binds to STAT3, facilitating its transportation and accumulation in the nucleus. JAKs induce the tyrosine phosphorylation of STAT3. The phosphorylated STAT3 forms a dimer and translocates from ...

Contact: Naoki NAMBA (Media Officer)
pr@oia.hokudai.ac.jp
81-117-068-034
Hokkaido University

Immune-Based Therapy in Mice Shows Promise against Pancreatic Cancer

Immune-Based Therapy in Mice Shows Promise against Pancreatic Cancer
Pancreatic tumors are surrounded by a protective "nest" made of fibrotic scar tissue and the cells that manufacture it (red). A new study in mice demonstrates that disrupting this fibrous ...

Contact: Diane Duke Williams
williamsdia@wustl.edu
314-286-0111
Washington University School of Medicine

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