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Dr. Scott Ramsey, Fred Hutchinson Cancer Research Center

Dr. Scott Ramsey, Fred Hutchinson Cancer Research Center
Is it possible to create public policy that will rein in the skyrocketing costs of cancer-fighting drugs? Dr. Scott Ramsey, a Fred Hutch physician, cancer researcher and health economist addresses ...

Contact: Sandy Van
svan2@fredhutch.org
808-526-1708
Fred Hutchinson Cancer Research Center

Recurrent DSB Clusters in Neural Stem/Progenitor Cells

Recurrent DSB Clusters in Neural Stem/Progenitor Cells
Recurrent DSB clusters in neural stem/progenitor cells are shown.

Contact: Kristen Dattoli
kristen.dattoli@childrens.harvard.edu
617-919-3141
Boston Children's Hospital

Nimbolide Induces Pancreatic Cancer Cell Death

Nimbolide Induces Pancreatic Cancer Cell Death
Microscopic images show how nimbolide induces authophagy, or cell death, in human pancreatic cancer cells. (Green fluorescence indicates autophagy.) Right image shows human pancreatic cancer cells ...

Contact: Veronique Masterson
veronique.masterson@ttuhsc.edu
915-215-4858
Texas Tech University Health Sciences Center El Paso

Nimbolide Vs. Control in Treating Pancreatic Cancer

Nimbolide Vs. Control in Treating Pancreatic Cancer
Time-lapse video showing how the neem tree extract nimbolide affects pancreatic cancer cells' growth in vitro. Left: Human pancreatic cancer cells left untreated begin to spread. Right: Human ...

Contact: Veronique Masterson
veronique.masterson@ttuhsc.edu
915-215-4858
Texas Tech University Health Sciences Center El Paso

Lung Cancer

Lung Cancer
Tumour tissue from a mouse with lung cancer is shown.

Contact: Vanessa Pombo
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

David Hill, PhD, Dana-Farber Cancer Institute

David Hill, PhD, Dana-Farber Cancer Institute
Dr. David Hill led a first large-scale systematic study that found most sibling proteins- - known as "protein isoforms" encoded by the same gene -- often play radically different roles ...

Contact: Anne Doerr
anne_doerr@dfci.harvard.edu
617-632-5665
Dana-Farber Cancer Institute

Dendritic Cells Make Leukemia Grow

Dendritic Cells Make Leukemia Grow
T-cell acute lymphoblastic leukemia, a cancer that strikes primarily in childhood, can only survive and grow when sent a signal from neighboring cells called dendritic cells (shown in green) in the ...

Contact: Christine Sinatra
christine.sinatra@austin.utexas.edu
512-471-4641
University of Texas at Austin

The Process of Converting a Mesenchymal Cell into Epithelial, and Vice Versa

The Process of Converting a Mesenchymal Cell into Epithelial, and Vice Versa
The figure shows changes in a cell shape and a number of other changes -- for example, those in internal cell structure, plus the contacts between cells. In addition, on the right side of the figure, ...

Contact: Valerii Roizen
press@mipt.ru
7-929-992-2721
Moscow Institute of Physics and Technology

Treatment Scheme

Treatment Scheme
This image shows the treatment scheme.

Contact: Valerii Roizen
press@mipt.ru
7-929-992-2721
Moscow Institute of Physics and Technology

The 'Dark Side' of the Transcriptome

The 'Dark Side' of the Transcriptome
A new method to detect, quantify and visualize RNA splicing helps to shed light on the "dark side" of the transcriptome: complex splicing variations that have been known to exist but have ...

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Drosophila Wing Model

Drosophila Wing Model
In the picture, precursor cells of fly wing tissue, labelled for various proteins. This fly model has been used to perform experiments addressing the relationship between chromosome instability, ...

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)

Nanoparticle Reduces Targeted Cancer Drug's Toxicity

Nanoparticle Reduces Targeted Cancer Drug's Toxicity
The polymeric nanoparticle Accurin encapsulates the clinical candidate AZD2811, an Aurora B kinase inhibitor. This material relates to a paper that appeared in the Feb. 10, 2016 issue of Science ...

Contact: Natasha Pinol
npinol@aaas.org
202-326-7088
American Association for the Advancement of Science

Hydrogels Slow Down Stem Cells

Hydrogels Slow Down Stem Cells
Using a hydrogel that mimics the mucus around embryos in diapause, researchers are able to prevent stem cells and human embryos from differentiating.

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

ADP-Ribosylation

ADP-Ribosylation
This is a photograph of cells in culture react to stress by massive ADP-ribosylation (red) in the nucleus (blue).

Contact: Michael O. Hottiger
hottiger@dmmd.uzh.ch
41-446-355-474
University of Zurich

Age-Related Gastric Decline in <em>Drosophila</em>

Age-Related Gastric Decline in Drosophila
Age-related gastric decline in Drosophila is indicated by acid-producing copper cells (red, anti-Cut).

Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2080
Buck Institute for Research on Aging

Meditation Reduces Stress During Biopsy

Meditation Reduces Stress During Biopsy
Meditation reduces stress during biopsy.

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

3-D view of Helicase

3-D view of Helicase
This movie shows the helicase protein complex from all angles, and reveals how its shape changes back and forth between two forms. The research team hypothesizes that the rocking action of this ...

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory

CMG Helicase Structure

CMG Helicase Structure
These are two images showing the structure of the helicase protein complex from above. (a) A surface-rendered three-dimensional electron density map as obtained by cryo-EM. (b) A computer-generated '...

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory

Faulty Bioelectric Signal Responsible for Rare Facial Defects

Faulty Bioelectric Signal Responsible for Rare Facial Defects
Tufts University biologists have discovered that faulty bioelectric signaling is responsible for the skull and facial abnormalities that characterize the rare genetic disorder Andersen-Tawil Syndrome...

Contact: Kim Thurler
kim.thurler@tufts.edu
617-627-3175
Tufts University

MicroRNA (miR-34a)

MicroRNA (miR-34a)
Duke scientists grew two sets of cellular "miniguts" on culture dishes and stimulated them with inflammatory factors. The miniguts on the left are normal. But on the right, the deletion of a...

Contact: Ken Kingery
ken.kingery@duke.edu
919-660-8414
Duke University

Adenovirus Dampens Host DNA Damage Response -- Implications for Control and Cancer Therapy

Adenovirus Dampens Host DNA Damage Response -- Implications for Control and Cancer Therapy
Cells infected with a virus lacking E4orf4 (top) or a virus expressing this protein (bottom) were stained by fluorescent antibodies showing the presence of the virus (green) and activation of the DDR...

Contact: Tamar Kleinberger
tamark@tx.technion.ac.il
972-482-95257
PLOS

Adenovirus Dampens Host DNA Damage Response -- Implications for Control and Cancer Therapy

Adenovirus Dampens Host DNA Damage Response -- Implications for Control and Cancer Therapy
Cells with normal or defective DDR pathways were infected with viruses lacking E4orf4 or viruses expressing it. The progression of virus infection is visualized by the appearance of infected cell ...

Contact: Tamar Kleinberger
tamark@tx.technion.ac.il
972-482-95257
PLOS

Neural Crest Cells

Neural Crest Cells
The image shows induced human neural crest cells. Human embryonic stem cells display neural crest characteristic expression after only five days of culture under WNT induction. Transcription factors ...

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside

Antibody Targets Multiple Sites to Outsmart Drug-Resistant Colorectal Cancer (1 of 1)

Antibody Targets Multiple Sites to Outsmart Drug-Resistant Colorectal Cancer (1 of 1)
Antibodies that block epidermal growth factor receptor (EGFR), a surface receptor that drives cancer growth, are effective against colorectal cancer, but many patients develop resistance. Researchers ...

Contact: Science Press Package
scipak@aaas.org
202-326-6440
American Association for the Advancement of Science

Modifying Hepatitis E Virus-like Particles to Target Cancer Cells

Modifying Hepatitis E Virus-like Particles to Target Cancer Cells
Hepatitis E virus capsids can resist passing through the digestive system. These virus-like particles could be used to carry vaccines or drugs into the body through the oral route. By modifying the ...

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis

Cystine RCC

Cystine RCC
The majority of kidney cell carcinomas are missing the VHL tumor-suppressor gene. Duke researchers showed that these renal cancer cells remain healthy when all nutrients are present (left panel), but ...

Contact: Karl Bates
karl.bates@duke.edu
919-681-8054
Duke University

Section of a Head and Neck Cancer Biopsy

Section of a Head and Neck Cancer Biopsy
Section of a head and neck cancer biopsy was stained for p21 (brown) and for S6 phosphorylation (red). S6 phosphorylation depends directly on mTOR and, therefore, its detection is an indication of ...

Contact: Vanessa Pombo
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Common Signature Found in Tumor DNA 5 Types of Cancer

Common Signature Found in Tumor DNA 5 Types of Cancer
The signature results from a chemical modification of DNA called methylation, which can control the expression of genes like a dimmer on a light switch. They hope this finding will spur development of...

Contact: Jeannine Mjoseth
Mjosethj@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute

Epigenetic Enzyme Inhibition

Epigenetic Enzyme Inhibition
Human breast cancers (blue) grown on mice show marked reductions in inflammatory cytokines such as IL1a and IL6 (yellow) when MLL1 is inhibited.

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Peptide cp28

Peptide cp28
The compound Cp28 (orange) binds to the EGF protein (green), a target in cancer. This interaction prevents EGF from binding to its receptor EGFR.

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)

Gene- Fusion Mutation

Gene- Fusion Mutation
Three-Way mechanism drives pediatric low-grade gliomas.

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Chinnaiyan Lab

Chinnaiyan Lab
Arul Chinnaiyan, right, consults with one of his lab associates.

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Autophagy Deregulation

Autophagy Deregulation
This image shows the implication of autophagy deregulation in Parkinson's disease (PD).

Contact: Hayley London
hayley.london@tgac.ac.uk
01-603-450-107
The Genome Analysis Centre

Autophagy

Autophagy
TGAC's Autophagy Regulatory Network resource provides an integrated and systems-level source for autophagy ('biological self-destruction') research in humans, features in the recent "Guidelines ...

Contact: Hayley London
hayley.london@tgac.ac.uk
01-603-450-107
The Genome Analysis Centre

Height Influences Risk of Major Non-Communicable Diseases

Height Influences Risk of Major Non-Communicable Diseases
This infographic shoes that tall people have a lower risk for cardiovascular disease and type 2 diabetes, but a higher risk of cancer due to dietary and interacting factors such as genetics and stress...

Contact: Dr. Astrid Glaser
glaser@dzd-ev.de
Deutsches Zentrum fuer Diabetesforschung DZD

Brain Tumor Vascularisation

Brain Tumor Vascularisation
Brain tumor vascularisation is visualized using T2*-weighted magnetic resonance imaging.

Contact: Emily Packer
e.packer@elifesciences.org
01-223-855-373
eLife

Brain Tumor Microvessels

Brain Tumor Microvessels
Brain tumor microvessels are visualized using dual-color ultramicroscopy.

Contact: Emily Packer
e.packer@elifesciences.org
01-223-855-373
eLife

<I>Escherichia coli</I>

Escherichia coli
Research on the effect of the enzyme APOBEC3G on DNA replication was conducted in the bacteria Escherichia coli.

Contact: Kevin D. Fryling
kfryling@iu.edu
812-856-2988
Indiana University

Accumulation of dihydroceramides after ABC294640 administration

Accumulation of dihydroceramides after ABC294640 administration
The signal for ABC294640 is detected only when the drug but not the vehicle was administered (upper panel). The intensity for two different dihydroceramides is shown in the middle panel (dhC16-cer) ...

Contact: Heather Woolwine
woolwinh@musc.edu
843-792-7669
Medical University of South Carolina

Leukemia Cells

Leukemia Cells
Leukemia cells (yellow) are shown dispersed among fat cells (red) and surrounded by supportive cells (blue).

Contact: Ellin Kavanagh
ekavanagh@chla.usc.edu
323-361-8505
Children's Hospital Los Angeles

Zebrafish Eggs

Zebrafish Eggs
On the far right, a zebrafish embryo breaks free from a group of unhatched sibling eggs.

Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-794-2272
University of California - Los Angeles Health Sciences

A Breast Cancer Metastasis in the Lungs

A Breast Cancer Metastasis in the Lungs
A metastasis now growing in lung tissue (blue) that originated from at least two cells (red and green) from a multicolored tumor in the mammary gland of a mouse.

Contact: Catherine Gara
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine

Aster Formation

Aster Formation
Asters form as motor protein draws the minus ends of the purple microtubules together.

Contact: Leah Burrows
lburrows@seas.harvard.edu
617-495-1351
Harvard John A. Paulson School of Engineering and Applied Sciences

Spontaneous Contraction of Microtubules

Spontaneous Contraction of Microtubules
The microtubules organize into networks that spontaneously contract.

Contact: Leah Burrows
lburrows@seas.harvard.edu
617-495-1351
Harvard John A. Paulson School of Engineering and Applied Sciences

Epigenomic Communication System

Epigenomic Communication System
The epigenomic communication system of embryonic stem cells can be explored interactively on the following website: http://epistemnet.bioinfo.cnio.es.

Contact: Vanessa Pombo
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

DNA Methylation Heatmap

DNA Methylation Heatmap
A DNA methylation gene marker panel was designed to identify three distinctive IDHmutant groups. Shown here is a heatmap, where samples with a high amount of methylation appear in red, and those with ...

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center

Special Issue: New Insights on Obesity and Anti-Obesity Therapy (1 of 2)

Special Issue: New Insights on Obesity and Anti-Obesity Therapy (1 of 2)
This is a schematic of possible maternal influences on cancer risk in offspring. In a maternal obesogenic environment, offspring cells could inherit malfunctioning mitochondria and/or deregulated ...

Contact: Science Press Package
scipak@aaas.org
202-326-6440
American Association for the Advancement of Science

Reach and Reel In

Reach and Reel In
Cancerous cells "recruit" cells into tumors by extending a bridge of sorts and reeling in both healthy and cancerous cells. The UI researchers documented the phenomenon for the first time in...

Contact: Richard Lewis
richard-c-lewis@uiowa.edu
319-384-0012
University of Iowa

Cellular Health

Cellular Health
Researchers at the University of Iowa tracked in real time the movement of individual, healthy cells and cancerous breast tissue cells. This video shows that healthy breast tissue cells remain ...

Contact: Richard Lewis
richard-c-lewis@uiowa.edu
319-384-0012
University of Iowa

Evil Envoys

Evil Envoys
Researchers at the University of Iowa tracked in real time the movement of individual cancerous breast tissue cells. The video shows how the cancerous cells extend and probe for other cells, then reel...

Contact: Richard Lewis
richard-c-lewis@uiowa.edu
319-384-0012
University of Iowa

Bussmann Simulation Image

Bussmann Simulation Image
Proton density after laser impact on a spherical solid density target: irradiated by an ultra-short, high intensity laser (not in picture) the intense electro-magnetic field rips electrons apart from ...

Contact: Eric Gedenk
gedenked@ornl.gov
865-241-5497
DOE/Oak Ridge National Laboratory

Precision Medicine Infographic

Precision Medicine Infographic
Infographic describing clinical genomic sequencing in pediatric oncology.

Contact: Anne Doerr
anne_doerr@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute

UW Microscope Video

UW Microscope Video
The UW's miniature microscope uses "dual-axis confocal microscopy" to illuminate and more clearly see through opaque tissue. This video shows images of fluorescent blood vessels in a mouse ear at ...

Contact: Jennifer Langston
jlangst@uw.edu
206-543-2580
University of Washington

UW Dual-Axis Confocal Microscope

UW Dual-Axis Confocal Microscope
University of Washington mechanical engineers and collaborators have developed a handheld microscope to help doctors and dentists distinguish between healthy and cancerous cells in an office setting ...

Contact: Jennifer Langston
jlangst@uw.edu
206-543-2580
University of Washington

Crouching Protein, Hidden Enzyme

Crouching Protein, Hidden Enzyme
New research from The Scripps Research Institute and UC Berkeley shows the workings of a crucial molecular enzyme. In this image, the green glow in the structure indicates the location of the Rpn11 ...

Contact: Madeline McCurry-Schmidt
madms@scripps.edu
858-784-9254
Scripps Research Institute

Structural Details of Dimerization and RNA Binding of T-STAR STAR Domain

Structural Details of Dimerization and RNA Binding of T-STAR STAR Domain
Top: Overview of the structure of T-STAR STAR domain in complex with AUUAAA RNA. Bottom left: close up view of the specific recognition of the RNA. Bottom right: close up view of the KH dimerization ...

Contact: Dr. Cyril Dominguez
cd180@le.ac.uk
University of Leicester

Microscopic 'Depots' Concentrate Drugs Inside Cancer Tumors

Microscopic 'Depots' Concentrate Drugs Inside Cancer Tumors
Biomedical engineering researchers have developed a technique for creating microscopic "depots" for trapping drugs inside cancer tumors. In an animal model, these drug depots were 10 times ...

Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University

Cancer Stem Cells

Cancer Stem Cells
A new inhibitor suppresses tumor growth and cancer stem cells. The image on the left shows beta catenin (red) in cell nuclei indicating that these are cancer stem cells. The image on the right shows ...

Contact: Josef Zens
josef.zens@mdc-berlin.de
49-309-406-2118
Max Delbrück Center for Molecular Medicine in the Helmholtz Association

Cedars-Sinai Breast Cancer Expert Discusses Latest Mammogram Guidelines and Controversy

Cedars-Sinai Breast Cancer Expert Discusses Latest Mammogram Guidelines and Controversy

https://youtu.be/xBcGtcaoDmM

In a new video, breast cancer expert Catherine Dang, M.D., explains the controversy surrounding the ...

Contact: Diane Wedner
Diane.Wedner@cshs.org
310-248-6608
Cedars-Sinai Medical Center

Route to Diagnosis and Stage for Bowel Cancer

Route to Diagnosis and Stage for Bowel Cancer
Route to diagnosis and stage for bowel cancers in England, 2012-2013.

Contact: Paul Thorne
paul.thorne@cancer.org.uk
44-203-469-8352
Cancer Research UK

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