IMAGE: Lung squamous cell carcinoma

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A Tale of 2 Tumor Environments

A Tale of 2 Tumor Environments
Mikala Egeblad's team showed in mice that the progression of different types of breast cancer was influenced differently by the tissue -- the so-called tumor microenvironment -- in which the tumor is ...

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Mangrove

Mangrove
A mangrove tunicate clings to a tree root.

Contact: Ian Demsky
idemsky@umich.edu
734-647-9837
University of Michigan

Fission Yeast Cells in the Process of Dividing

Fission Yeast Cells in the Process of Dividing
The pink spots mark the DNA. The green lines are support structures that form during cell division to assist chromosome segregation.

Contact: Kaoru Natori
kaoru.natori@oist.jp
81-989-662-389
Okinawa Institute of Science and Technology (OIST) Graduate University

Condensin Is a Key Player in Successful Chromosome Segregation

Condensin Is a Key Player in Successful Chromosome Segregation
The cells on the left are normal yeast cells, in the process of dividing successfully. As can be seen, the replicated chromosomes have completely separated from the original. The cells on the right ...

Contact: Kaoru Natori
kaoru.natori@oist.jp
81-989-662-389
Okinawa Institute of Science and Technology (OIST) Graduate University

Immunofluorescence Image

Immunofluorescence Image
Immunofluorescence image is of multinucleate osteoclast generated by exposure of pre-osteoclast cells to lysyl oxidase (Red = cell body phalloidin, blue = DNA).

Contact: Amy Pullan
a.l.pullan@sheffield.ac.uk
07-549-645-180
University of Sheffield

This Slinky Lookalike 'Hyperlens' Helps Us See Tiny Objects

This Slinky Lookalike 'Hyperlens' Helps Us See Tiny Objects
The image shows a metamaterial hyperlens. The light-colored slivers are gold and the darker ones are PMMA (a transparent thermoplastic). Light passes through the hyperlens improving the resolution of ...

Contact: Cory Nealon
cmnealon@buffalo.edu
716-645-4614
University at Buffalo

Epithelial Lining

Epithelial Lining
This image shows the epithelial lining of the gut.

Contact: Andrew Chapple
andrew.chapple@ifr.ac.uk
44-160-325-1490
Norwich BioScience Institutes

Marrow-Infiltrating Lymphocytes

Marrow-Infiltrating Lymphocytes
This image shows marrow-infiltrating lymphocytes in cell culture.

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Device

Device
Cells enter the device and move through it.

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Cells

Cells
Individual cancer cells were isolated with a new device. The cell on the left is less likely to metastasize.

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Pancreatic Cancer Spreading to the Liver

Pancreatic Cancer Spreading to the Liver
This infographic illustrates the precise molecular steps that enable pancreatic cancer to spread to the liver.

Contact: Jen Gundersen
jeg2034@med.cornell.edu
646-317-7402
Weill Cornell Medical College

Quantitative Phase Images of An Unstained Prostatectomy Sample

Quantitative Phase Images of An Unstained Prostatectomy Sample
Left: Quantitative phase image of an unstained prostatectomy sample from a patient who had a biochemical recurrence of prostate cancer. Right: A zoomed-in region from the quantitative phase image ...

Contact: Maeve Reilly
mjreilly@illinois.edu
217-244-7316
Beckman Institute for Advanced Science and Technology

CTC Cluster Magnification

CTC Cluster Magnification
This is a magnification of a circulating tumor cell cluster captured by Cluster-Chip.

Contact: Margot Kern
nibibpress@mail.nih.gov
301-496-3500
NIH/National Institute of Biomedical Imaging & Bioengineering

Fluorescent CTC Cluster Captured in Cluster-Chip

Fluorescent CTC Cluster Captured in Cluster-Chip
A fluorescently labelled cancer cell cluster balances on the tip of a post within Cluster-Chip.

Contact: Margot Kern
nibibpress@mail.nih.gov
301-496-3500
NIH/National Institute of Biomedical Imaging & Bioengineering

CTC Cluster Captured on Cluster-Chip

CTC Cluster Captured on Cluster-Chip
A three-cell circulating tumor cell cluster is captured and held by the balanced fluid flow on either side of the triangular microposts on the Cluster-Chip.

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital

Cluster-Chip

Cluster-Chip
Circulating tumor cell clusters can be captured from patient blood samples passed through the more than 4,000 parallel trapping paths in the Cluster-Chip.

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital

Cluster-Chip Micropost Rows

Cluster-Chip Micropost Rows
On the Cluster-Chip, multiple roles of triangular microposts can capture circulating tumor cell clusters in a blood sample.

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital

<I>Drosophila melanogaster</I>

Drosophila melanogaster
This is a Drosophila melanogaster specimen.

Contact: Dr Eran Tauber (PhD)
et22@le.ac.uk
44-011-625-23455
University of Leicester

Color Plot

Color Plot
A color plot showing the expression level during the day in early (larks) and late (owls) strains of Drosophila. Purple colour represents an expression level above mean, bright green colour ...

Contact: Dr Eran Tauber (PhD)
et22@le.ac.uk
44-011-625-23455
University of Leicester

Antibody Structure

Antibody Structure
Known as the Fc domain, the stem of Y-shaped antibodies (above) can activate immune cells via their Fc receptors. The two arms, meanwhile, target foreign proteins. A new study has found Fc receptors ...

Contact: Wynne Parry
wparry@rockefeller.edu
212-327-7789
Rockefeller University

Men Running

Men Running
Testosterone, the hormone that puts a spring in a man's step, may also lead to benign prostate hyperplasia -- enlarged prostate -- according to a study by UCSB researchers - See more at: Contact: Andrea Estrada
andrea.estrada@ucsb.edu
805-893-4620
University of California - Santa Barbara

Blair Paulik, Oregon State University

Blair Paulik, Oregon State University
Blair Paulik, graduate student in environmental chemistry at Oregon State University, checks on an air-pollution sampler in Carroll County, Ohio.

Contact: Kim Anderson
kim.anderson@oregonstate.edu
541-737-8501
Oregon State University

Breast Tissue is Stained to Show Hematoxylin and Eosin (Large Tissue Section).

Breast Tissue is Stained to Show Hematoxylin and Eosin (Large Tissue Section).
Two regions are se-lected to show an overlayer of molecular staining (left, cytokeratin; right, Masson's trichrome). All three stains are computationally generated using chemical imaging data obtained...

Contact: Philly Lim
mllim@wspc.com.sg
65-646-65775
World Scientific

Femtomedicine Process

Femtomedicine Process
Researchers have identified new molecules that kill cancer cells while protecting healthy cells and that could be used to treat a variety of different cancers. The research shines a light on what ...

Contact: Nick Manning
nmanning@uwaterloo.ca
226-929-7627
University of Waterloo

Killer T-cells

Killer T-cells
This is a cytotoxic T cell -- the body's 'serial killers' -- as it hunts down and eliminates cancer cells.

Contact: Craig Brierley
craig.brierley@admin.cam.ac.uk
44-122-376-6205
University of Cambridge

Circos Diagram

Circos Diagram
This is a circos diagram showing the mutanome of the mouse CT26 colon carcinoma.

Contact: Dr. Reneé Dillinger-Reiter
pr@unimedizin-mainz.de
49-613-117-7424
Johannes Gutenberg Universitaet Mainz

Blood Vessels

Blood Vessels
This is an image of blood vessels in the heart (shown in red). The large vessel is surrounded by smaller vessels (capillaries). The nuclei are shown in blue, and the neurons are green.

Contact: Dr. Stefanie Dimmeler
herfurth@med.uni-frankfurt.de
Goethe University Frankfurt

Stem Cell Lab University of Washington

Stem Cell Lab University of Washington
At a University of Washington stem cell research laboratory, Dr. Hannele Ruohola-Baker (right) examines a specimen with Dr. Julie Mathieu.

Contact: Leila Gray
leilag@uw.edu
206-685-0381
University of Washington Health Sciences/UW Medicine

New Harvard Research Finds Walnuts May Help Slow Colon Cancer Growth

New Harvard Research Finds Walnuts May Help Slow Colon Cancer Growth
A walnut-enriched diet may cause beneficial genetic changes in animal cancer cells, affecting inflammation, blood supply and growth of tumors.

Contact: Erin Farkaly
erin.farakly@edelman.com
415-486-3256
Edelman Seattle

How CAR T-cell Therapy Works

How CAR T-cell Therapy Works
To view an interactive version of this graphic and get embed codes to include it in your copy, visit: https://dl.dropboxusercontent.com/u/1995996/DF-BC/CAR_T-cell_immunotherapy_for_cancer.html

Contact: Irene Sege
irene.sege@childrens.harvard.edu
617-919-3110
Dana-Farber Cancer Institute

Human Cancer Cells Going Through the Process of Division

Human Cancer Cells Going Through the Process of Division
These microscope images show human cancer cells going through the process of division. The cell on the left is untreated whereas the cell on the right has lost Hsp70. This reveals how interfering with...

Contact: Andrew Fry
amf5@le.ac.uk
01-162-297-069
University of Leicester

Lung Cancer Cells -- CNIO

Lung Cancer Cells -- CNIO
Lung cancer cells treated with the CNIO TRF1 inhibitor ETP-47037 (right) show less TRF1 bound to the telomeres (green, top), more telomeric DNA damage (pink, bottom), and therefore, an acute telomere ...

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

A Test to Spot Cancer Cells' Achilles' Heels

A Test to Spot Cancer Cells' Achilles' Heels
In leukemia cells, the CRISPR-based method surveyed about 200 potential drug targets in proteins and successfully identified the 6 already known (red spikes) -- most of which are at the focus of ...

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Mitosis

Mitosis
This image showsn normal cell dividing (left) and stressed cancer cell dividing (right). PLK1 inhibitors stress cancer cells, making them easier to kill.

Contact: Heather Buschman
hbuschman@ucsd.edu
619-543-6163
University of California - San Diego

Human Cancer Cells

Human Cancer Cells
These microscope images show human cancer cells going through the process of division. The cell on the left is untreated whereas the cell on the right has lost Hsp70. This reveals how interfering with...

Contact: Andrew Fry
amf5@le.ac.uk
01-162-297-069
University of Leicester

Prior Pregnancy Affects Milk Production

Prior Pregnancy Affects Milk Production
The mammary gland in previously pregnant mice (bottom row) produces milk earlier in a second pregnancy than in mice of the same age experiencing pregnancy for the first time (top row). For purposes ...

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Mammary Cells 'remember' Earlier Pregnancy

Mammary Cells 'remember' Earlier Pregnancy
These images show the effect of pregnancy hormones after 6 and 12 days on breast tissue in mice that have never been pregnant (top row) and mice that have been pregnant once before (bottom row). The ...

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Examples of Varying Amounts of Background Parenchymal Enhancement

Examples of Varying Amounts of Background Parenchymal Enhancement
These are examples of varying amounts of background parenchymal enhancement (BPE), as prospectively assessed qualitatively. Axial postcontrast maximum intensity projection MR images show (a) minimal...

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America

Porous Silicon Microparticles

Porous Silicon Microparticles
The porous silicon microparticles are about 1 micrometer in diameter. The hollow channels within each microparticle can be loaded with antigens -- such as HER2 -- that can help train the immune system...

Contact: David Bricker
dmbricker@houstonmethodist.org
832-667-5811
Houston Methodist

Lung Cancer

Lung Cancer
An image of lung cancer.

Contact: Jamie Brown
jamie.brown@manchester.ac.uk
01-612-758-383
University of Manchester

Identification of DNA repair proteins by mass spectrometry

Identification of DNA repair proteins by mass spectrometry
Collision of the DNA replication machinery with lesions in the DNA triggers the recruitment of a large number of DNA repair factors (yellow) that help to repair the lesions. In proteomic analyses ...

Contact: Anja Konschak
konschak@biochem.mpg.de
49-898-578-2824
Max Planck Institute of Biochemistry

Centromere Stabilization

Centromere Stabilization
The direct binding of CENP-C to the CENP-A nucleosome stabilizes hydrogen bonding within internal secondary structures of the CENP-A nucleosome. Stars indicate fluorescent probes that move closer to ...

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Searching for Brain Cancer Treatments

Searching for Brain Cancer Treatments
Scientists found that the drug panobinostat may be effective at treating diffuse intrinsic pontine gliomas, the leading cause of pediatric brain cancer death.

Contact: Christopher G. Thomas
thomaschr@ninds.nih.gov
30-149-657-511
NIH/National Institute of Neurological Disorders and Stroke

Searching for Brain Cancer Treatments

Searching for Brain Cancer Treatments
Michelle Monje, M.D., Ph.D., discusses pediatric brain cancer and her efforts to find new treatments.

Contact: Christopher G. Thomas
thomaschr@ninds.nih.gov
30-149-657-511
NIH/National Institute of Neurological Disorders and Stroke

3-D Organoid Culture Screening

3-D Organoid Culture Screening
3-D organoid cultures derived from healthy and tumor tissue from colorectal cancer patients are used for a high throughput drug screen to identify genedrug associations that may facilitate ...

Contact: Joseph Caputo
jcaputo@cell.com
617-335-6270
Cell Press

DNA Loops

DNA Loops
DNA looping can bring a promoter and a distant enhancer close together inside the nucleus. Photo courtesy of Kelvin Song.

Contact: Kaoru Natori
kaoru.natori@oist.jp
81-989-662-389
Okinawa Institute of Science and Technology (OIST) Graduate University

Promoter Interactions

Promoter Interactions
A graphic shows how many more promoter interactions (purples arcs) are captured by the Capture Hi-C method (second track) versus the regular Hi-C method (first track). The interactions from a single ...

Contact: Kaoru Natori
kaoru.natori@oist.jp
81-989-662-389
Okinawa Institute of Science and Technology (OIST) Graduate University

Accelerator of the Compact Light Source

Accelerator of the Compact Light Source
The compact synchrotron light source generates highly focused, monochromatic X-rays, thus allowing to measure not only X-ray absorption, but also phase shifts and scattering. The phase contrast, dark ...

Contact: Dr. Andreas Battenberg
battenberg@zv.tum.de
49-892-891-0510
Technische Universitaet Muenchen

Synchrotron X-Ray Images of a Mouse

Synchrotron X-Ray Images of a Mouse
X-ray images of a mouse show: normal X-ray image, phase contrast and darkfield image (fltr). The phase contrast, dark field and absorption images acquired using the new compact synchrotron have ...

Contact: Dr. Andreas Battenberg
battenberg@zv.tum.de
49-892-891-0510
Technische Universitaet Muenchen

Honey Bee Feeds on a Flower

Honey Bee Feeds on a Flower
Insects, like many mammals, depend on detecting different types of odors to find food, mates, and shelter, and even to defend themselves.

Contact: Sandra Leander
sandra.leander@asu.edu
480-965-9865
Arizona State University

Insects Depend on Detecting Different Types of Odor

Insects Depend on Detecting Different Types of Odor
Odor plumes (monitored with TiCl4 smoke) break up into thin filaments. Odor filaments from different odor sources (green and magenta) intermingle. The area chart shows the fluctuations of odor ...

Contact: Sandra Leander
sandra.leander@asu.edu
480-965-9865
Arizona State University

Salk Institute Explains New Stem Cell Growth Findings

Salk Institute Explains New Stem Cell Growth Findings
Salk researchers have uncovered details about stem cell growth that could help improve regenerative therapies and treatment for colon cancer.

Contact: Salk Communications
press@salk.edu
Salk Institute

Two New Pathways in Stem Cell Growth Revealed

Two New Pathways in Stem Cell Growth Revealed
In early-stage cell nuclei (blue), developmental genes (green) must be turned on for the cell to develop. When the two cellular processes, Wnt and Activin, work together (upper left), genes are ...

Contact: Salk Communications
press@salk.edu
Salk Institute

Pancreatic Cancer Maps

Pancreatic Cancer Maps
Maps depict global incidence rates of pancreatic cancer (per 100,000) and ultraviolet B radiation (watts per square meter).

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

EEG, Electroencephalogram

EEG, Electroencephalogram
Breast cancer survivors were asked to complete a set of tasks while researchers monitored their brain activity.

Contact: Heather Amos
heather.amos@ubc.ca
604-822-3213
University of British Columbia

Senescent Vs. Non-Senescent Cells

Senescent Vs. Non-Senescent Cells
Shown on the left is an ATM positive cell that has undergone senescence (depicted by blue color). On the right are cells with low ATM that are not senescent due to a cancer-like change in metabolism.

Contact: Ben Leach
bleach@wistar.org
215-495-6800
The Wistar Institute

Anti-HIV Drug May Combat Adult Leukemia

Anti-HIV Drug May Combat Adult Leukemia
Adult T-cell leukemia cells are described as "flower cells." This material relates to a paper that appeared in the April 24, 2015, issue of Science, published by AAAS. The paper, by K. Tada at ...

Contact: Science Advances Press Package
vancepak@aaas.org
202-326-6440
American Association for the Advancement of Science

Antonio Jimeno, University of Colorado Denver

Antonio Jimeno, University of Colorado Denver
Antonio Jimeno, M.D., Ph.D., and University of Colorado Cancer Center colleagues report in Oncogene a new model, XactMice, which uses human blood stem cells to grow "humanized" mouse immune ...

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

TMPRSS2

TMPRSS2
This is an image of TMPRSS2.

Contact: Erin Vollick
erin.vollick@dentistry.utoronto.ca
41-697-949-004-381
University of Toronto - Faculty of Dentistry

Skin Nevus

Skin Nevus
The mutation BrafV600E is found in 70 percent or more of benign birthmarks and moles in humans. Scientists believe the Braf mutation alone isn't enough to cause cancer. A variety of ...

Contact: David Bricker
dmbricker@houstonmethodist.org
832-667-5811
Houston Methodist

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