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Turning the Tables

Turning the Tables
Turning the tables, Katherine Borden at the University of Montreal's Institute for Research in Immunology and Cancer (IRIC) has evoked Star Trek's Borg in her fight against the disease. "Cancer cells ...

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal

Star Trek's Borg Evoked

Star Trek's Borg Evoked
Turning the tables, Katherine Borden at the University of Montreal's Institute for Research in Immunology and Cancer (IRIC) has evoked Star Trek's Borg in her fight against the disease. "Cancer cells ...

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal

3BrPA (red)

3BrPA (red)
3BrPA (red) is illustrated encased in a sugar-based microshell.

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

MCF-7 Cells

MCF-7 Cells
Pictured are MCF-7 human breast cancer cells, stably transformed with SNAIL (right) or an empty vector control (left). Cells expressing SNAIL show an increased mesenchymal phenotype and malignant ...

Contact: Brett Israel
brett.israel@comm.gatech.edu
404-385-1933
Georgia Institute of Technology

Synthetic Molecules that Mimic Antibodies

Synthetic Molecules that Mimic Antibodies
SyAMs recognize disease cells and bind with a specific protein on their surface. They also bind with a receptor on an immune cell.

Contact: Jim Shelton
james.shelton@yale.edu
203-432-3881
Yale University

Direct Reprogramming

Direct Reprogramming
Dermal fibroblasts are directly reprogrammed to pigmented melanocytes by three transcription factors (SOX10, MITF and PAX3).

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Comparison between the Normal Cervical Tissue and Tissue Lesion for Different Stages

Comparison between the Normal Cervical Tissue and Tissue Lesion for Different Stages
This shows a comparison between the normal cervical tissue and tissue lesion for different stages. From top to bottom are the pathological images for the normal cervical tissue (first row) and tissue ...

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
The Optical Society

Hydrogel Activation

Hydrogel Activation
A hydrogel with a cross-linked fluorescent group that had been caged with a molecular 'hat' was irradiated with UV light to remove the caging group and activate fluorescence. The patterning is ...

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology

Light-Activated Peptide

Light-Activated Peptide
Researchers have developed a technique for activating biological signals through the skin of a living animal using light. In this illustration, ultraviolet light is shining through a pattern, ...

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology

Red, Green and Blue Outputs Provided by Fluorescent Proteins

Red, Green and Blue Outputs Provided by Fluorescent Proteins
UMass Amherst chemists have devised a multi-channel signature-based approach to screening drugs using a gold nanoparticles with red, green and blue outputs provided by fluorescent proteins.

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst

Bacteria Forming a Mixed Biofilm on Colon Cancer Tissue

Bacteria Forming a Mixed Biofilm on Colon Cancer Tissue
Bacteria forms a mixed biofilm on colon cancer tissue.

Contact: Diana Kenney
dkenney@mbl.edu
508-289-7139
Marine Biological Laboratory

Genetic Cancer Connections

Genetic Cancer Connections
An algorithm called HotNet2 helps define the terrain for complex genetic associations involved in cancer. 'The next step,' says researcher Ben Raphael, 'is translating all of this information from ...

Contact: Kevin Stacey
kevin_stacey@brown.edu
401-863-3766
Brown University

Microwave Imaging of the Breast

Microwave Imaging of the Breast
These are internal, spatially mapped microwave tomography system generated electrical property distribution images of a cancer patient's left breast, taken somewhat into her therapy. Shown are ...

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
American Institute of Physics

Microwave Breast Imager

Microwave Breast Imager
This image shows an image of a microwave breast tomography instrument.

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
American Institute of Physics

Follicle Progenitors

Follicle Progenitors
Fruit fly ovarian follicle progenitor cells, with different colors marking a specific kind of activity (red) specific gene expression (green) and nuclear DNA (blue).

Contact: Allan Spradling
spradling@ciwemb.edu
Carnegie Institution

New Breast Cancer Classification Based on Epigenetics

New Breast Cancer Classification Based on Epigenetics
This is an image of a breast tumor identified as Epi-Luminal B of poor prognosis.

Contact: Arantxa Mena
amena@idibell.cat
0034-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute

A Potential Battery Terminal?

A Potential Battery Terminal?
This image shows the complex multiscale structure of a carbonized mouse spleen.

Contact: Neal Singer
nsinger@sandia.gov
505-845-7078
DOE/Sandia National Laboratories

DNA Double-Strand Break by the Endonuclease I-DmoI

DNA Double-Strand Break by the Endonuclease I-DmoI
The video illustrates how the I-DmoI endonuclease nicks the phosphodiester bonds that maintain the structural backbone of the DNA. Based on the initial state (State 1), we can observe: two consecutive...

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Enzyme I-DmoI

Enzyme I-DmoI
The enzyme I-DmoI (purple) is specifically associated to the double strand of DNA (yellow and green).

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Young and Old Cells Exposed to Fluorescent Antibodies

Young and Old Cells Exposed to Fluorescent Antibodies
Young and old cells exposed to fluorescent antibodies against the novel markers. Old cells can be easily identified because they shine bright under the microscope.

Contact: Salvador Macip
sm460@le.ac.uk
University of Leicester

Molecular Signal Helps Cancer Cells Dodge Death

Molecular Signal Helps Cancer Cells Dodge Death
A cell's ability to divide in two is fundamental to life. These white blobs show DNA being separated as cells divide. But if mistakes are made, this can lead to genetic errors, and cancer.

Contact: Stephanie McClellan
stephanie.mcclellan@cancer.org.uk
44-203-469-5314
Cancer Research UK

Cancer Cells

Cancer Cells
The image shows cancer cells where the number of chromosomes in each nucleus is not as it should be -- a condition known as "aneuploidy." The green spots show a marker for the chromosomes, and the red...

Contact: Stephanie McClellan
stephanie.mcclellan@cancer.org.uk
44-203-469-5314
Cancer Research UK

Walton's Mushrooms

Walton's Mushrooms
A team of Michigan State University scientists has discovered an enzyme that is the key to the lethal potency of poisonous mushrooms.

Contact: Layne Cameron
layne.cameron@cabs.msu.edu
517-353-8819
Michigan State University

Many Neurons Expressing Topoisomerase-1

Many Neurons Expressing Topoisomerase-1
THis image shows neurons from a mouse expressing the gene Topoisomerase-1, in white.

Contact: Mark Derewicz
mark.derewicz@unchealth.unc.edu
919-923-0959
University of North Carolina Health Care

Neurons Expressing Topoisomerase-1

Neurons Expressing Topoisomerase-1
This image shows neurons expressing the Topoisomerase-1 gene, in green.

Contact: Mark Derewicz
mark.derewicz@unchealth.unc.edu
919-923-0959
University of North Carolina Health Care

Dual Function of TRBP

Dual Function of TRBP
By analyzing cells with genetic deletion of TRBP, the research team revealed cell cycle dependent regulation of PKR by TRBP and evaluated the function of TRBP in microRNA biogenesis.

Contact: Hanbin Oh
ohanvin@ibs.re.kr
82-428-788-182
Institute for Basic Science

Activation of PKR by dsRNAs During Mitosis

Activation of PKR by dsRNAs During Mitosis
When cells are undergoing division, intermixing of cellular compartments allow dsRNAs and PKR to interact, leading to activation of PKR. When activated, PKR regulates protein synthesis and mitotic ...

Contact: Hanbin Oh
ohanvin@ibs.re.kr
82-428-788-182
Institute for Basic Science

Transforming Cancer Research: The Genomic Data Commons

Transforming Cancer Research: The Genomic Data Commons
The establishment of the NCI Genomic Data Commons will expand access for scientists around the country, speeding up research and, in turn, leading to faster discoveries for patients. The GDC will ...

Contact: Kevin Jiang
kevin.jiang@uchospitals.edu
773-795-5227
University of Chicago Medical Center

Approved Drug Tamoxifen, Molecular Weapon to Treat Blood Neoplasms

Approved Drug Tamoxifen, Molecular Weapon to Treat Blood Neoplasms
This study suggests that the blood stem cells (pink for female, blue for male) that, when altered, produce excessive blood cells (diseases called neoplasms) can be killed by female sex hormones. This ...

Contact: Ainhoa Iriberri
airiberri@cnic.es
34-610-295-556
Centro Nacional de Investigaciones Cardiovasculares

Graphical Abstract of Study

Graphical Abstract of Study
This is a graphic of the study. This discovery has a potential application in the treatment of certain blood disorders for which there is currently no cure.

Contact: Ainhoa Iriberri
airiberri@cnic.es
34-610-295-556
Centro Nacional de Investigaciones Cardiovasculares

Histological Section Cutting

Histological Section Cutting
This image shows a histological section cutting of a primary tumour before and after treatment with Bozepinib.

Contact: Juan Antonio Marchal Corrales
jmarchal@ugr.es
0034-958-249-321
University of Granada

Supercomputer Titan

Supercomputer Titan
Supercomputer Titan is at the Oak Ridge National Laboratory in the state of Tennessee, USA.

Contact: Christine Bohnet
c.bohnet@hzdr.de
49-351-260-2450
Helmholtz-Zentrum Dresden-Rossendorf

Mammospheres

Mammospheres
This image shows floating mammospheres containing breast cancer stem cells.

Contact: Jamie Brown
jamie.brown@manchester.ac.uk
01-612-758-383
University of Manchester

Spot Maginification

Spot Maginification
A spot magnification view demonstrates an irregular spiculated mass with associated calcifications in the upper outer left breast.

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America

Screening Mammogram

Screening Mammogram
This is a screening mammogram demonstrating calcifications in the upper outer left breast. Bilateral cranio-caudal views shown here.

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America

Bilateral MLO

Bilateral MLO
These are bilateral MLO views from screening mammography.

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America

Mammography Comparison

Mammography Comparison
A malignancy easily missed on 2-D mammography was clearly seen on 3-D mammography.

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America

Undulator Hall

Undulator Hall
This is the undulator hall of Linac Coherent Light Source at SLAC.

Contact: Andreas Battenberg
battenberg@zv.tum.de
49-892-891-0510
Technische Universitaet Muenchen

Schematic of TH-GM Causing Neuroinflammation, Demyelination and Nerve System Damage

Schematic of TH-GM Causing Neuroinflammation, Demyelination and Nerve System Damage
A new type of T cell, TH-GM, produces a cytokine, GM-CSF, to recruit and activate other inflammatory cells, including macrophages, to cause neuroinflammation, demyelination and nerve system damage.

Contact: Kimberley Wang
kimberley.wang@nus.edu.sg
National University of Singapore

High-Dose Interleukin-2 Effective in mRCC Pre-Treated with VEGF-Targeted Therapies

High-Dose Interleukin-2 Effective in mRCC Pre-Treated with VEGF-Targeted Therapies
High-dose interleukin-2 can be effective in selected metastatic renal cell cancer patients pre-treated with VEGF-targeted agents, reveals research presented today at the ESMO Symposium on Immuno-...

Contact: ESMO Press Office
media@esmo.org
European Society for Medical Oncology

Microtubules

Microtubules
Rice University scientists are using custom software to help explain the dynamic instability seen at all times in microtubules, essential elements of a cell's cytoskeleton. The individual elements are...

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University

PHD Controls the Epidermal Growth Factor Reptor

PHD Controls the Epidermal Growth Factor Reptor
A special PHD protein, PHD3, also controls the epidermal growth factor receptor (EGFR). In healthy cells, PHD3 responds to stressors such as a lack of oxygen by stimulating the uptake of EGF receptors...

Contact: Amparo Acker-Palmer
Acker-Palmer@bio.uni-frankfurt.de
49-069-798-42563
Goethe University Frankfurt

Targeted Cancer Treatment with Nuclear Medicine Therapy

Targeted Cancer Treatment with Nuclear Medicine Therapy

The Society of Nuclear Medicine and Molecular Imaging (SNMMI) has released a new infographic showing how certain types of cancer can be treated using nuclear medicine therapy. Targeted Cancer ...

Contact: Kimberly Brown
kbrown@snmmi.org
703-652-6773
Society of Nuclear Medicine

Balch Paper Image

Balch Paper Image
This schematic shows the transition from a healthy protein folding state (green) to an unhealthy, maladaptive state (red) -- a maladaptive stress response -- that occurs in response to chronic ...

Contact: Madeline McCurry-Schmidt
madms@scripps.edu
858-784-9254
Scripps Research Institute

Lung Cancer Treatment

Lung Cancer Treatment
A mutation of the KRAS gene leads to a common and hard-to-treat lung cancer. A new combination therapy (lipophilic bisphosphonate and rapamycin) administered to mice for 40 days resulted in shrunken ...

Contact: Salk Communications
press@salk.edu
Salk Institute

Powerful One-Two Punch Targets Lung Cancer

Powerful One-Two Punch Targets Lung Cancer
A mutation of the KRAS gene leads to a common and hard-to-treat lung cancer. Salk researchers find a powerful combination therapy that targets this cancer.

Contact: Salk Communications
press@salk.edu
Salk Institute

New Technology Spots Better Drug Targets

New Technology Spots Better Drug Targets
Researchers at the Salk Institute explain how a new technology, called ReBiL, can spot protein interactions more accurately, providing a new tool for cancer and other drug diagnostics.

Contact: Salk Communications
press@salk.edu
Salk Institute

Yao-Cheng Li and Geoffrey Wahl, Salk Institute

Yao-Cheng Li and Geoffrey Wahl, Salk Institute
Salk researcher Yao-Cheng Li and professor Geoffrey Wahl developed a new technology for visualizing protein interactions, which could lead to better cancer drugs.

Contact: Salk Communications
press@salk.edu
Salk Institute

Willow Cutting in Lab

Willow Cutting in Lab
UW researchers Sharon Doty and Zareen discuss the next experimental design using willow.

Contact: Sandra Hines
shines@uw.edu
206-543-2580
University of Washington

Willow Treated with Microbe from Eastern Cottonwood

Willow Treated with Microbe from Eastern Cottonwood
Willow cuttings treated with a microbe that naturally occurs in an eastern cottonwood are able to withstand the toxic effects of growing in a solution with the industrial pollutant phenanthrene. ...

Contact: Sandra Hines
shines@uw.edu
206-543-2580
University of Washington

Willow without Protective Treatment

Willow without Protective Treatment
Willow cuttings without the treatment ceased growing, lost leaves and died when grown in solution with phenanthrene.

Contact: Sandra Hines
shines@uw.edu
206-543-2580
University of Washington

Metasis-Free Survival Rates and BRCA

Metasis-Free Survival Rates and BRCA
This table shows 3-, 5- and 10-year metastasis-free survival according to the treatment and presence of BRCA mutations.

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Hand Washing

Hand Washing
Triclosan is an antimicrobial additive found in many liquid hand soaps and other household products.

Contact: Heather Buschman
hbuschman@ucsd.edu
619-543-6163
University of California - San Diego

KRAS Image

KRAS Image
Using bioluminescence, researchers showed that the novel molecule 'KRAS silencing RNA' or 'KRAS siRNA' (right) reduced the size of a tumor in mice. Researchers used a 'non-KRAS silencing' molecule as ...

Contact: Mark Derewicz
mark.derewicz@unchealth.unc.edu
919-923-0959
University of North Carolina Health Care

Epithelial-Mesenchymal Transition (EMT) Scoring System

Epithelial-Mesenchymal Transition (EMT) Scoring System
This is the epithelial-mesenchymal transition scoring system which shows EMT scores across various cancers.

Contact: Kimberley Wang
kimberley.wang@nus.edu.sg
National University of Singapore

Exosomes

Exosomes
This image shows mice orthotopical breast xenograft serum exosomes.

Contact: Arantxa Mena
amena@idibell.cat
34-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute

Leukemia Cells

Leukemia Cells
Leukemia cells are shown.

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-5653
Dana-Farber Cancer Institute

TexRAD Ccans

TexRAD Ccans
A standard CT scan (top left) with the tumor outlined in white. With the TexRAD software applied, healthcare professionals can analyze the tumor's texture at a fine (red), medium (green) and coarse (...

Contact: James Hakner
press@sussex.ac.uk
44-127-367-8888
University of Sussex

Dartmouth Study: Lung Cancer Screening with Low-Dose CT Could Be Cost Effective

Dartmouth Study: Lung Cancer Screening with Low-Dose CT Could Be Cost Effective
Dartmouth researchers say lung cancer screening in the National Lung Screening Trial meets a commonly accepted standard for cost effectiveness as reported in the Nov. 6 issue of the New England ...

Contact: Rick Adams
Clarence.R.Adams@hitchcock.org
603-653-1910
The Geisel School of Medicine at Dartmouth

Neochromosomes

Neochromosomes
This animation describes how neochromosomes form.

Contact: Alison Heather
a.heather@garvan.org.au
61-292-958-128
Garvan Institute of Medical Research

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