IMAGE: Lung squamous cell carcinoma

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CXCR4

CXCR4
The newly solved structure of the CXCR4 receptor (black) in complex with a chemokine (purple surface). The background shows cell migration, a process driven by chemokines interacting with receptors on...

Contact: Heather Buschman
hbuschman@ucsd.edu
619-543-6163
University of California - San Diego

Electron Microscope Image of a Harmful Neutrophil

Electron Microscope Image of a Harmful Neutrophil
This is an electron microscope image of a harmful neutrophil described in the research of Dr. Zvika Granot and Dr. Zvi Fridlender.

Contact: Dov Smith
dovs@savion.huji.ac.il
972-258-82844
The Hebrew University of Jerusalem

One Nanoparticle, 6 Types of Imaging

One Nanoparticle, 6 Types of Imaging
University at Buffalo researchers and colleagues have designed a nanoparticle detectable by six medical imaging techniques. This illustration depicts the particles as they are struck by beams of ...

Contact: Charlotte Hsu
chsu22@buffalo.edu
716-645-4655
University at Buffalo

TEM Image, Nanoparticles

TEM Image, Nanoparticles
This transmission electron microscopy image shows the nanoparticles, which consist of a core that glows blue when struck by near-infrared light, and an outer fabric of porphyrin-phospholipids (PoP) ...

Contact: Charlotte Hsu
chsu22@buffalo.edu
716-645-4655
University at Buffalo

Effect of 4-HAP

Effect of 4-HAP
Treating cells with 4-HAP causes the protein myosin II to move to the cells' periphery, making them stiffer.

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine

Cell Division

Cell Division
This video shows the process of cell division.

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine

Liver Cancer

Liver Cancer
The calcium influx into the liver carcinoma cell can be monitored following the exposure to citronellal (pictured in pseudo-colours).

Contact: Hanns Hatt
hanns.hatt@rub.de
49-234-322-4586
Ruhr-University Bochum

Antibodies in Action

Antibodies in Action
The figure shows human blood vessel cells (endothelial cells) grown outside the body. When endothelial cells are grown on a mixture of proteins that normally surround blood vessels, they form blood ...

Contact: Peter Kristensen
pk@eng.au.dk
45-20-36-90-97
Aarhus University

An Alternative Target for Cancer Therapy at the Ends of Chromosomes

An Alternative Target for Cancer Therapy at the Ends of Chromosomes
This movie shows that an ATR inhibitor induces numerous DNA breaks in ALT-positive cancer cells. ALT-positive U2OS osteosarcoma cells were treated with the ATR inhibitor VE-821 and analyzed by live ...

Contact: Science Press Package
scipak@aaas.org
202-326-6440
American Association for the Advancement of Science

Quantum Dot

Quantum Dot
This is the protein corona of firefly luciferase around a CdSe quantum dot.

Contact: Matt Wheeler
mrwheele@syr.edu
215-443-4777
Syracuse University

CNIO Study Scheme

CNIO Study Scheme
This is a scheme illustrating the study that has identified variants in the CYP3A4 gene associated with paclitaxel severe neuropathy.

Contact: Vanessa Pombo
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Live <i>Conus regius</i> (Cone Snail)

Live Conus regius (Cone Snail)
Professor Frank Marí in the Charles E. Schmidt College of Science at Florida Atlantic University holds a live Conus regius, a particular species of cone snail collected by the Marí...

Contact: Gisele Galoustian
ggaloust@fau.edu
561-297-2676
Florida Atlantic University

A look at Blood Stem Cell Development in Zebrafish

A look at Blood Stem Cell Development in Zebrafish
This image captures a blood stem cell en route to taking root in a zebrafish.

Contact: Irene Sege
irene.sege@childrens.harvard.edu
617-919-3110
Boston Children's Hospital

Broccoli

Broccoli
Research in the Linus Pauling Institute has found that sulforaphane, found in foods such as broccoli, may be able to play a role in cancer therapy.

Contact: Emily Ho
Emily.ho@oregonstate.edu
541-737-9559
Oregon State University

Higher STAT3 Activity

Higher STAT3 Activity
Patients with high PRL-3 expression harbor higher STAT3 activity. (A) The list of genes in the STAT3 core signature. (B) Comparison of the PRL-3 expression (upper panels) and STAT3 activity (C) ...

Contact: Kimberley Wang
kimberley.wang@nus.edu.sg
National University of Singapore

Interaction between STAT3 and PRL-3

Interaction between STAT3 and PRL-3
This is a schematic of the interaction between STAT3 and PRL-3 in contributing to the development and progression of AML.

Contact: Kimberley Wang
kimberley.wang@nus.edu.sg
National University of Singapore

Squamous-Cell Bladder Carcinoma

Squamous-Cell Bladder Carcinoma
This image shows a squamous-cell bladder carcinoma from Notch-deficient mice.

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Glioblastoma

Glioblastoma
Glioblastoma is a notoriously difficult-to-treat brain cancer with an often poor prognosis. Virginia Tech Carilion Research Institute scientists are developing innovative cross-disciplinary therapies ...

Contact: Paula Brewer Byron
paulabyron@vt.edu
540-526-2027
Virginia Tech

Lung Cancer's Association with Elevation.

Lung Cancer's Association with Elevation.
In the left hand panel, lung cancer incidence is plotted against elevation for western US counties. Darker counties have higher populations and thus lower observational errors. The right hand panel ...

Contact: Kamen Simeonov
kamen.simeonov@gmail.com
304-685-3206
PeerJ

Stout TH Image

Stout TH Image
The new study provides insight into how a critical mitochondrial enzyme, transhydrogenase (TH), works in a process that is key to maintaining healthy cells

Contact: Madeline McCurry-Schmidt
madms@scripps.edu
858-784-9254
Scripps Research Institute

Synthesis of Marine Alkaloid, Dictyodendrin, Using Selective C-H Functionalization Strategies

Synthesis of Marine Alkaloid, Dictyodendrin, Using Selective C-H Functionalization Strategies
This figure shows the synthesis of marine alkaloid, dictyodendrin, using selective C-H functionalization strategies.

Contact: Dr. Ayako Miyazaki
press@itbm.nagoya-u.ac.jp
81-527-894-999
Institute of Transformative Bio-Molecules (ITbM), Nagoya University

Ether Lipids and Neutrophils

Ether Lipids and Neutrophils
A structure in cells that makes key enzymes previously linked to diabetes and obesity, also appears to be important in seemingly unrelated disorders, such as arthritis and leukemia. and endocrinology ...

Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine

Bone Marrow in Mice with Suppressed Ether Lipid Production

Bone Marrow in Mice with Suppressed Ether Lipid Production
The bone marrow of mice with normal ether lipid production (top) contains more white blood cells than are found in the bone marrow of mice with ether lipid deficiency (bottom).

Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine

Graphene 'Flying Carpet' Delivers 2 Anti-Cancer Drugs Sequentially

Graphene 'Flying Carpet' Delivers 2 Anti-Cancer Drugs Sequentially
Researchers have attached two drugs -- TRAIL and Dox -- onto graphene strips. TRAIL is most effective when delivered to the external membrane of a cancer cell, while Dox is most effective when ...

Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University

Nutrition Education May Help Prevent Breast Cancer Reoccurrence

Nutrition Education May Help Prevent Breast Cancer Reoccurrence
Breast cancer is the most frequent cause of death among women worldwide, and five-year survival rates are just 58.4 percent in Brazil, lower than in many other regions. In a new study, however, ...

Contact: Eileen Leahy
jnebmedia@elsevier.com
732-238-3628
Elsevier Health Sciences

Phototherapy System

Phototherapy System
A new system developed at Oregon State University to improve cancer surgery uses a nanoparticle called a dendrimer to carry a drug into cancer cells, that can set the stage for improved surgery and ...

Contact: Oleh Taratula
oleh.taratula@oregonstate.edu
541-737-5785
Oregon State University

Bowhead Whale (2 of 2)

Bowhead Whale (2 of 2)
This is a bowhead whale underwater.

Contact: Joseph Caputo
jcaputo@cell.com
617-397-2802
Cell Press

Bowhead Whale (1 of 2)

Bowhead Whale (1 of 2)
This is the head of a bowhead whale.

Contact: Joseph Caputo
jcaputo@cell.com
617-397-2802
Cell Press

Scientists Develop the First 3-D Culture System for Pancreatic Cancer

Scientists Develop the First 3-D Culture System for Pancreatic Cancer
A team of researchers has developed a method to grow pancreatic tissue in a three-dimensional culture system, called organoids. The scientists are able to use tissue not only from laboratory mouse ...

Contact: Jaclyn Jansen
jjansen@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Cell Ties

Cell Ties
This image shows normal cells (left) compared to when the cell ties are broken down (right).

Contact: Emily Head
press.office@cancer.org.uk
020-346-96189
Cancer Research UK

Stages of Fibrosis

Stages of Fibrosis
Interdisciplinary research at the University of Pennsylvania is showing how cells interact over long distances within fibrous tissue, like that associated with many diseases of the liver, lungs and ...

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania

Fiber Simulations

Fiber Simulations
The team's simulations showed that these bridges formed as collagen fibers aligned in the direction the tissue was stretched.

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania

A Clear Difference

A Clear Difference
Dysregulation of the protein CHI3L1 allows melanoma (black specks) to spread to the lungs of mice. CHI3L1 was relatively unchecked in the lung on the right, compared to the lung on the left, which had...

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

Blocking Excessive Division of Cell Powerhouses Reduces Liver Cell Death in Cholestasis

Blocking Excessive Division of Cell Powerhouses Reduces Liver Cell Death in Cholestasis
The power plants that fuel liver cells rapidly splinter when exposed to bile salts that aid digestion, prompting cell death, but blocking this excessive fission appears to protect the liver, according...

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University

CNIO Researchers Activate Hair Growth by Modifying Immune Cells

CNIO Researchers Activate Hair Growth by Modifying Immune Cells
This is a skin whole mount section showing hair follicles (blue) surrounded by clusters of skin resident macrophages (red). The molecular communication between macrophages and hair follicle stem cells...

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Turning the Tables

Turning the Tables
Turning the tables, Katherine Borden at the University of Montreal's Institute for Research in Immunology and Cancer (IRIC) has evoked Star Trek's Borg in her fight against the disease. "Cancer cells ...

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal

Star Trek's Borg Evoked

Star Trek's Borg Evoked
Turning the tables, Katherine Borden at the University of Montreal's Institute for Research in Immunology and Cancer (IRIC) has evoked Star Trek's Borg in her fight against the disease. "Cancer cells ...

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal

3BrPA (red)

3BrPA (red)
3BrPA (red) is illustrated encased in a sugar-based microshell.

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

MCF-7 Cells

MCF-7 Cells
Pictured are MCF-7 human breast cancer cells, stably transformed with SNAIL (right) or an empty vector control (left). Cells expressing SNAIL show an increased mesenchymal phenotype and malignant ...

Contact: Brett Israel
brett.israel@comm.gatech.edu
404-385-1933
Georgia Institute of Technology

Synthetic Molecules that Mimic Antibodies

Synthetic Molecules that Mimic Antibodies
SyAMs recognize disease cells and bind with a specific protein on their surface. They also bind with a receptor on an immune cell.

Contact: Jim Shelton
james.shelton@yale.edu
203-432-3881
Yale University

Direct Reprogramming

Direct Reprogramming
Dermal fibroblasts are directly reprogrammed to pigmented melanocytes by three transcription factors (SOX10, MITF and PAX3).

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Comparison between the Normal Cervical Tissue and Tissue Lesion for Different Stages

Comparison between the Normal Cervical Tissue and Tissue Lesion for Different Stages
This shows a comparison between the normal cervical tissue and tissue lesion for different stages. From top to bottom are the pathological images for the normal cervical tissue (first row) and tissue ...

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
The Optical Society

Hydrogel Activation

Hydrogel Activation
A hydrogel with a cross-linked fluorescent group that had been caged with a molecular 'hat' was irradiated with UV light to remove the caging group and activate fluorescence. The patterning is ...

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology

Light-Activated Peptide

Light-Activated Peptide
Researchers have developed a technique for activating biological signals through the skin of a living animal using light. In this illustration, ultraviolet light is shining through a pattern, ...

Contact: John Toon
jtoon@gatech.edu
404-894-6986
Georgia Institute of Technology

Red, Green and Blue Outputs Provided by Fluorescent Proteins

Red, Green and Blue Outputs Provided by Fluorescent Proteins
UMass Amherst chemists have devised a multi-channel signature-based approach to screening drugs using a gold nanoparticles with red, green and blue outputs provided by fluorescent proteins.

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst

Bacteria Forming a Mixed Biofilm on Colon Cancer Tissue

Bacteria Forming a Mixed Biofilm on Colon Cancer Tissue
Bacteria forms a mixed biofilm on colon cancer tissue.

Contact: Diana Kenney
dkenney@mbl.edu
508-289-7139
Marine Biological Laboratory

Genetic Cancer Connections

Genetic Cancer Connections
An algorithm called HotNet2 helps define the terrain for complex genetic associations involved in cancer. 'The next step,' says researcher Ben Raphael, 'is translating all of this information from ...

Contact: Kevin Stacey
kevin_stacey@brown.edu
401-863-3766
Brown University

Microwave Imaging of the Breast

Microwave Imaging of the Breast
These are internal, spatially mapped microwave tomography system generated electrical property distribution images of a cancer patient's left breast, taken somewhat into her therapy. Shown are ...

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
American Institute of Physics

Microwave Breast Imager

Microwave Breast Imager
This image shows an image of a microwave breast tomography instrument.

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
American Institute of Physics

Follicle Progenitors

Follicle Progenitors
Fruit fly ovarian follicle progenitor cells, with different colors marking a specific kind of activity (red) specific gene expression (green) and nuclear DNA (blue).

Contact: Allan Spradling
spradling@ciwemb.edu
Carnegie Institution

New Breast Cancer Classification Based on Epigenetics

New Breast Cancer Classification Based on Epigenetics
This is an image of a breast tumor identified as Epi-Luminal B of poor prognosis.

Contact: Arantxa Mena
amena@idibell.cat
0034-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute

A Potential Battery Terminal?

A Potential Battery Terminal?
This image shows the complex multiscale structure of a carbonized mouse spleen.

Contact: Neal Singer
nsinger@sandia.gov
505-845-7078
DOE/Sandia National Laboratories

DNA Double-Strand Break by the Endonuclease I-DmoI

DNA Double-Strand Break by the Endonuclease I-DmoI
The video illustrates how the I-DmoI endonuclease nicks the phosphodiester bonds that maintain the structural backbone of the DNA. Based on the initial state (State 1), we can observe: two consecutive...

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Enzyme I-DmoI

Enzyme I-DmoI
The enzyme I-DmoI (purple) is specifically associated to the double strand of DNA (yellow and green).

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Young and Old Cells Exposed to Fluorescent Antibodies

Young and Old Cells Exposed to Fluorescent Antibodies
Young and old cells exposed to fluorescent antibodies against the novel markers. Old cells can be easily identified because they shine bright under the microscope.

Contact: Salvador Macip
sm460@le.ac.uk
University of Leicester

Molecular Signal Helps Cancer Cells Dodge Death

Molecular Signal Helps Cancer Cells Dodge Death
A cell's ability to divide in two is fundamental to life. These white blobs show DNA being separated as cells divide. But if mistakes are made, this can lead to genetic errors, and cancer.

Contact: Stephanie McClellan
stephanie.mcclellan@cancer.org.uk
44-203-469-5314
Cancer Research UK

Cancer Cells

Cancer Cells
The image shows cancer cells where the number of chromosomes in each nucleus is not as it should be -- a condition known as "aneuploidy." The green spots show a marker for the chromosomes, and the red...

Contact: Stephanie McClellan
stephanie.mcclellan@cancer.org.uk
44-203-469-5314
Cancer Research UK

Walton's Mushrooms

Walton's Mushrooms
A team of Michigan State University scientists has discovered an enzyme that is the key to the lethal potency of poisonous mushrooms.

Contact: Layne Cameron
layne.cameron@cabs.msu.edu
517-353-8819
Michigan State University

Many Neurons Expressing Topoisomerase-1

Many Neurons Expressing Topoisomerase-1
THis image shows neurons from a mouse expressing the gene Topoisomerase-1, in white.

Contact: Mark Derewicz
mark.derewicz@unchealth.unc.edu
919-923-0959
University of North Carolina Health Care

Neurons Expressing Topoisomerase-1

Neurons Expressing Topoisomerase-1
This image shows neurons expressing the Topoisomerase-1 gene, in green.

Contact: Mark Derewicz
mark.derewicz@unchealth.unc.edu
919-923-0959
University of North Carolina Health Care

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