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A New Pathway to Get at HER2-Positive Breast Cancer

A New Pathway to Get at HER2-Positive Breast Cancer
Mammary epithelial cells grow in clusters called acini. When HER2 signaling is activated, the clusters -- which normally have hollow centers -- assume an irregular, or dysplastic form (left). When ...

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Breast Tumor

Breast Tumor
In stiffness levels similar to breast cancer (right), cells are better able to invade surrounding tissue and metastasize.

Contact: Heather Buschman
hbuschman@ucsd.edu
619-543-6163
University of California - San Diego

Proteins Attached to Nanoparticle

Proteins Attached to Nanoparticle
The image above illustrates how proteins (copper-colored coils) modified with polyhistidine-tags (green diamonds) can be attached to nanoparticles (red circle).

Contact: Cory Nealon
cmnealon@buffalo.edu
716-645-4614
University at Buffalo

Glio (3 of 3)

Glio (3 of 3)
The Rice University research team of graduate student Ka Wai Lin, left, bioengineer Amina Qutub, center, and undergraduate Angela Liao, right, have published a study that suggests drugs developed to ...

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University

Glio (1 of 3)

Glio (1 of 3)
A computational model shows the insulin signaling pathway found to have significance in the growth of glioblastomas. A new Rice University study suggests drugs developed to control the growth of brain...

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University

Glio (2 of 3)

Glio (2 of 3)
The Rice University research team of graduate student Ka Wai Lin, left, bioengineer Amina Qutub, center, and undergraduate Angela Liao, right, have published a study that suggests drugs developed to ...

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University

Myc's Deadly Mistake

Myc's Deadly Mistake
Transcription factor SRF is an important commander of the cell's well-being genes. Myc, when expressed at high levels as in cancer cells, invades to control regions of the well-being genes and ...

Contact: Dr. Juha Klefström
juha.klefstrom@helsinki.fi
358-294-125-493
University of Helsinki

Biomarker Predicts Effects of Vessel-Spurring Cancer Therapy

Biomarker Predicts Effects of Vessel-Spurring Cancer Therapy
Tumor vessels and pericyte treated with a Notch inhibitor. This material relates to a paper that appeared in the April 10, 2015, issue of Science, published by AAAS. The paper, by H. Iwamoto at...

Contact: Science Advances Press Package
vancepak@aaas.org
202-326-6440
American Association for the Advancement of Science

Hypothesis Illustration

Hypothesis Illustration
Novel mechanism in diseases: zinc deficiency can enhance Hedgehog (Hh) ligand production and activate Hh signal pathway. Zinc deficiency is well known in prostate cancer, lung cancer, ovarian cancer ...

Contact: Mary Martialay
martim12@rpi.edu
Rensselaer Polytechnic Institute

Aspirin

Aspirin
Aspirin use is rising in the US, a new survey shows.

Contact: Craig Williams
craig.williams@oregonstate.edu
503-494-1598
Oregon State University

Liver Cells

Liver Cells
Liver cells lacking TRF1 gene (right) show, under chronic stress, larger nuclei and other markers characteristic of patients with cirrhosis or hepatitis (an increase in p21, PCNA and cyclin D1), when ...

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Sulforadex

Sulforadex
This is sulforadex.

Contact: Jamie Brown
jamie.brown@manchester.ac.uk
44-161-275-8383
University of Manchester

4-D Cancer Model

4-D Cancer Model
The model developed by Dr. Min Kim and colleagues produces results quickly and solves the problems of existing models that are used to study cancer progression.

Contact: David Bricker
dmbricker@houstonmethodist.org
832-667-5811
Houston Methodist

ALCL Genetic Map Animation

ALCL Genetic Map Animation
This is an animation of the genetic map of ALCL.

Contact: Lucky Tran
lt2549@columbia.edu
212-305-3689
Columbia University Medical Center

ALCL Genetic Map

ALCL Genetic Map
This is a map of mutations observed in ALK-negative anaplastic large cell lymphoma.

Contact: Lucky Tran
lt2549@columbia.edu
212-305-3689
Columbia University Medical Center

Cell Junctions

Cell Junctions
Correct tight junctions between cells labeled in yellow due to the presence of the protein PARD3.

Contact: Arantxa Mena
amena@idibell.cat
34-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute

MCRS1 in Colorectal Cancer

MCRS1 in Colorectal Cancer
Human colorectal cancer samples express low levels of MCRS1 low (left) and high levels of MCRS1 (right).

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Two Neonatal Cardiomyocytes Undergoing Cell Division after Treatment with NRG1

Two Neonatal Cardiomyocytes Undergoing Cell Division after Treatment with NRG1
Two neonatal cardiomyocytes (stained red) undergoing cell division after treatment with NRG1 are shown.

Contact: Yael Edelman
yael.edelman@weizmann.ac.il
Weizmann Institute of Science

New Method Increases Accuracy of Ovarian Cancer Prognosis and Diagnosis

New Method Increases Accuracy of Ovarian Cancer Prognosis and Diagnosis
A personalized prognostic and diagnostic laboratory test for ovarian cancer would predict both the patient's survival and the tumor's sensitivity to platinum-based chemotherapy, and doctors could ...

Contact: Julie Kiefer
jkiefer@neuro.utah.edu
801-597-4258
University of Utah Health Sciences

The Tensor Generalized SVD

The Tensor Generalized SVD
Alter's team develops algorithms to uncover patterns in datasets arranged in multidimensional tables, known as tensors. Rather than simplifying the big data, as is commonly done, the algorithms make ...

Contact: Julie Kiefer
jkiefer@neuro.utah.edu
801-597-4258
University of Utah Health Sciences

D3 System for Molecular Tumor Profiling

D3 System for Molecular Tumor Profiling
By quantifying the number of tumor-marker-targeting microbeads bound to cells (lower images), the D3 system categorizes high- and low-risk cervical biopsy samples as well as traditional pathology (...

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital

Discovering Cancer Blockers

Discovering Cancer Blockers
Research at the University of Kansas has isolates six compounds that block the cancer-facilitating protein HuR.

Contact: Brendan M Lynch
brendan@ku.edu
785-864-8855
University of Kansas

High-Throughput Screening Leads to Cancer Breakthrough

High-Throughput Screening Leads to Cancer Breakthrough
Researchers at the University of Kansas isolated six molecules that block HuR, a protein that facilitates many kinds of cancer.

Contact: Brendan M Lynch
brendan@ku.edu
785-864-8855
University of Kansas

PTEN Travels along Microtubule

PTEN Travels along Microtubule
This super-resolution image shows clearly the association between PTEN tumor suppressor proteins (colored red) and networks of cellular "highways" called microtubules (colored green).

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

PTEN in a Cell

PTEN in a Cell
This image in ordinary resolution shows PTEN proteins (tiny white dots) suffused throughout a cell. New research explains how they are attracted to specific growth signals inside the cell that they ...

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Tumor Cells Can Mimic Blood Vessels, Helping Cancer Spread

Tumor Cells Can Mimic Blood Vessels, Helping Cancer Spread
This image shows two adjacent sections of a mouse breast tumor. The tissue at left is stained so that normal blood vessels can be seen (black arrow); extending from these vessels are blood filled ...

Contact: Peter Tarr
tarr@cshl.edu
516-367-5055
Cold Spring Harbor Laboratory

Directional Signals for Cancer Cells

Directional Signals for Cancer Cells
Yale-led research is looking into the directional cues that influence cancer cells.

Contact: Jim Shelton
james.shelton@yale.edu
203-432-3881
Yale University

Cancer Research Breakthrough Announced

Cancer Research Breakthrough Announced
A cancer research breakthrough was announced by two biotechnology companies.

Contact: Qingsong Zhu
zhu@insilicomedicine.com
410-710-9674
InSilico Medicine, Inc.

Kinase Reaction of Lapatinib

Kinase Reaction of Lapatinib
When the drug lapatinib inhibits the expression of the HER2 kinase in five different HER2-positive breast cancer cell lines, other kinases are also tamped down (blue) but several more kinases are ...

Contact: Mark Derewicz
mark.derewicz@unchealth.unc.edu
919-923-0959
University of North Carolina Health Care

Graphic Brazil Cigarette Warning

Graphic Brazil Cigarette Warning
Graphic ads like this by the Brazilian Health Ministry - Instituto Nacional do Câncer are more likely to get young adults to appreciate the dangers of smoking, according to research from ...

Contact: Renee Magnan
renee.magnan@vancouver.wsu.edu
360-546-9403
Washington State University

Fluorescent Nanoparticles in Cells

Fluorescent Nanoparticles in Cells
This image shows fluorescent nanoparticles in cells.

Contact: Stanislav Goryachev
stas.goryachev@gmail.com
7-964-501-2307
Moscow Institute of Physics and Technology

Coating

Coating
This image shows different types of coating for upconversion nanoparticles.

Contact: Stanislav Goryachev
stas.goryachev@gmail.com
7-964-501-2307
Moscow Institute of Physics and Technology

Microfluidic Chip Uses Sound Waves to Separate Circulating Tumor Cells from White Blood Cells

Microfluidic Chip Uses Sound Waves to Separate Circulating Tumor Cells from White Blood Cells
This schematic illustration shows the high-throughput device for separating cancer cells from white blood cells.

Contact: Jocelyn Duffy
jhduffy@andrew.cmu.edu
412-268-9982
Carnegie Mellon University

Personalized Vaccines Target Skin Cancer's Mutations

Personalized Vaccines Target Skin Cancer's Mutations
Vaccines engineered by Carreno et al. broadened the response of patients' T cells to certain mutations in their skin cancers. This material relates to a paper that appeared in the April 3, 2015...

Contact: Science Press Package
scipak@aaas.org
202-326-6440
American Association for the Advancement of Science

Improved Overall Survival as a Result of Combination Therapy

Improved Overall Survival as a Result of Combination Therapy
This is a depiction of Kaplan-Meier survival curve with genomically targeted agents (blue line) as compared to standard therapies (purple line), indicating an improvement in median overall survival ...

Contact: Joseph Caputo
jcaputo@cell.com
617-335-6270
Cell Press

Soft-shell Clams (2 of 3)

Soft-shell Clams (2 of 3)
These are soft-shell clams (Mya arenaria) from a seafood market in New York.

Contact: Joseph Caputo
jcaputo@cell.com
617-335-6270
Cell Press

Soft-shell Clams (3 of 3)

Soft-shell Clams (3 of 3)
These are soft-shell clams (Mya arenaria) from a seafood market in New York that are sitting on the lab bench while their hemolymph is checked for the presence of neoplastic cells.

Contact: Joseph Caputo
jcaputo@cell.com
617-335-6270
Cell Press

Soft-shell Clams (1 of 3)

Soft-shell Clams (1 of 3)
These are soft-shell clams (Mya arenaria) from a seafood market in New York.

Contact: Joseph Caputo
jcaputo@cell.com
617-335-6270
Cell Press

Nanoparticle for Anticancer Drug Delivery

Nanoparticle for Anticancer Drug Delivery
The nanoparticle is coated with a layer of polymer masking it from recognition and elimination by the immune system as it circulates in the body. When it reaches a tumor, it slowly releases a drug ...

Contact: Rachel Salis-Silverman
Salis@email.chop.edu
267-426-6063
Children's Hospital of Philadelphia

Infographic of How Prostate Cancer Spreads

Infographic of How Prostate Cancer Spreads
This infographic shows how prostate cancer spreads.

Contact: Emily Head
emily.head@cancer.org.uk
020-346-96189
Cancer Research UK

Wasting in Fly Ovaries

Wasting in Fly Ovaries
These are ovaries from normal and tumor-bearing flies, showing the tissue wasting induced by the tumor.

Contact: Joseph Caputo
jcaputo@cell.com
617-335-6270
Cell Press

Cancer Cells

Cancer Cells
Cancer cells, left, were pretreated with a drug that blocks the ERK signal, and right, without the pretreatment. Top cells are untreated, while the bottom ones are stimulated.

Contact: Yael Edelman
yael.edelman@weizmann.ac.il
Weizmann Institute of Science

Krebs Cycle, CNIO

Krebs Cycle, CNIO
Mutations in several Krebs cycle genes (IDH1/2, SDH, FH and now MDH2) lead to the accumulation of metabolites (2-HG, SUC and FUM), which cause important changes in gene expression (grey circle).

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Fast Functional Photoacoustic Microscopy

Fast Functional Photoacoustic Microscopy
These images show fast functional photoacoustic microscopy of the mouse brain. Figure (d, left) shows a representative x-y projected brain vasculature image through an intact skull. Figure (e) shows a...

Contact: Julie Flory
julie.flory@wustl.edu
Washington University in St. Louis

New Findings Support the Benefits of Eating Walnuts on Overall Health

New Findings Support the Benefits of Eating Walnuts on Overall Health
Multiple new research abstracts suggest walnuts may have the potential to positively affect several important health factors. From their impact on colon cancer and certain aspects of cognitive aging, ...

Contact: Erin Farkaly
erin.farkaly@edelman.com
415-202-3503
Edelman Seattle

Researchers Overcome Radiation Resistance in Leukemia With an Engineered Precision Medicine

Researchers Overcome Radiation Resistance in Leukemia With an Engineered Precision Medicine
CD19L-sTRAIL selectively binds to the CD19 receptor on leukemia cells via its CD19L moiety upon which its sTRAIL component kills the cells by engaging the TRAIL death receptors.

Contact: Sacha Boucherie
s.boucherie@elsevier.com
31-204-853-564
Elsevier

Cross Section of a Pubertal Mouse Mammary Duct

Cross Section of a Pubertal Mouse Mammary Duct
Id4+ stem cells are in red, luminal cells in green, and all cells are marked with blue nuclear dye.

Contact: Alison Heather
a.heather@garvan.org.au
61-292-958-128
Garvan Institute of Medical Research

MRI of Healthy Cells Vs. Cancer Cells

MRI of Healthy Cells Vs. Cancer Cells
Normal cells (left) have far more sugar attached to mucin proteins than do cancerous cells (right). Mucin-attached sugar generates a high MRI signal, shown in red.

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine

BHPI and Estrogen Receptor

BHPI and Estrogen Receptor
An experimental drug, BHPI, binds to the estrogen receptor and disrupts the growth of cancer cells.

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign

Stainless Staining

Stainless Staining
Breast tissue is computationally stained using data from infrared imaging without actually staining the tissue, enabling multiple stains on the same sample. From left, the image shows a Hematoxylin ...

Contact: Liz Ahlberg
eahlberg@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign

Molecular Labeling Machine

Molecular Labeling Machine
Scientists found the enzyme METTL3 (green) tags a particular sequence within RNA molecules destined to become gene-regulating microRNAs. While this happens within cells' nuclei (blue), METTL3 is also ...

Contact: Wynne Parry
wparry@rockefeller.edu
212-327-7789
Rockefeller University

Brain Tumor Cells Decimated by Mitochondrial

Brain Tumor Cells Decimated by Mitochondrial
The new drug MP-MUS (yellow) attacks cancer cell mitochondria by infiltrating both inner and outer membranes (green) after being converted from an inactive, non-toxic form to an active, toxic form by ...

Contact: Gale Smith
gsmith@houstonmethodist.org
281-627-0439
Houston Methodist

CK1α: The Achilles Heel of RAS-Driven Cancer Cells

CK1α: The Achilles Heel of RAS-Driven Cancer Cells
Removal of enzyme CK1α blocks cellular digestion in specific cancers.

Contact: Dharshini Subbiah
dharshini.subbiah@duke-nus.edu.sg
659-616-7532
Duke-NUS Graduate Medical School Singapore

Stress Granules Linked to Metastasis

Stress Granules Linked to Metastasis
The time-lapse video shows how the proteins YB-1 (green) and G3BP1 (red) overlap in stress granules, structures whose prevalence in tumors researchers now link to metastasis.

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

Stress Granules in Tumors

Stress Granules in Tumors
Fewer stress granules (yellow) occur in cancer cells lacking G3BP1 (right) than in controls (left). Nuclei are labeled blue.

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

Recruiting Dendritic Cells for Cancer Fight

Recruiting Dendritic Cells for Cancer Fight
This is an artist's representation of the surface of a human dendritic cell.

Contact: Barbara McMakin
nindspressteam@ninds.nih.gov
NIH/National Institute of Neurological Disorders and Stroke

A Urine Test for Kidney Cancer

A Urine Test for Kidney Cancer
Kidney cancer is the seventh most common type of cancer in men and the 10th most common in women, affecting about 65,000 people each year in the united states. Some 14,000 die of the disease each year...

Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine

Bucky-bomb

Bucky-bomb
This is an artist's illustration of a bucky-bomb.

Contact: Robert Perkins
perkinsr@usc.edu
213-740-9226
University of Southern California

Culprit in Colon Cancer

Culprit in Colon Cancer
Msi2 (stained red) is broadly expressed in intestinal tumors that result from loss of APC. Penn researchers believe activation of Msi2 downstream of APC loss drives metabolic activation of stem cells ...

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania

Benzopyrene

Benzopyrene
The way in which hazardous organic substances such as benzopyrene get into human cells, their impact and how they are dispersed is another topic that scientists at the UFZ are also investigating ...

Contact: Tilo Arnhold
presse@ufz.de
49-341-235-1635
Helmholtz Centre for Environmental Research - UFZ

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