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Fruit Fly Eyes

Fruit Fly Eyes
Michigan State University scientists look at fruit fly eyes to unlock the secrets of an important cancer gene.

Contact: Layne Cameron
layne.cameron@cabs.msu.edu
517-353-8819
Michigan State University

Wistar Leads SPORE Grant in Melanoma

Wistar Leads SPORE Grant in Melanoma
Wistar's Meenhard Herlyn, D.V.M., D.Sc., is the primary investigator of a $12.1 National Cancer Institute SPORE -- Specialized Project of Research Excellence -- grant in collaboration with researchers...

Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute

Proteins

Proteins
Researchers from Erlangen can identify individual unlabeled proteins by the weak shadow that the biomolecules produce when they scatter light. For their biosensor, the scientists use a very sensitive ...

Contact: Vahid Sandoghdar
vahid.sandoghdar@mpl.mpg.de
49-091-316-877-200
Max-Planck-Gesellschaft

Disease Associations

Disease Associations
University of Pennsylvania researchers identified several miRNA mutations that were associated with particular ethnic groups and had links to cancer and other diseases.

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania

Cancer Cells

Cancer Cells
This approach will take biological data and develop models to try to answer basic questions about cancer that can possibly help find a cure.

Contact: Ivy F. Kupec
ikupec@nsf.gov
703-292-8796
National Science Foundation

Acute Myeloid Leukemia Cells

Acute Myeloid Leukemia Cells
Harvard and MIT researchers discover that blood cancer cells (shown here) are less tolerant to shifts in their metabolism than their healthy counterparts.

Contact: Joseph Caputo
joseph_caputo@harvard.edu
617-496-1491
Harvard University

A Traditional Healer, Dar es Salaam

A Traditional Healer, Dar es Salaam
To improve treatment of psychosis in Tanzania, Grand Challenges Canada grantees will harness the power of ubiquitous mobile devices to bridge rural traditional healers and urban medical practitioners...

Contact: Terry Collins
tc@tca.tc
416-538-8712
Terry Collins Assoc

Sterile Drill Covers for Low-Cost Orthopedic Trauma Surgery

Sterile Drill Covers for Low-Cost Orthopedic Trauma Surgery
This low-cost, sterilizable cover enables the use of widely available commercial power drills for orthopedic trauma surgery in low-resource settings.

Contact: Terry Collins
tc@tca.tc
416-538-8712
Terry Collins Assoc

HPV Infographic

HPV Infographic
This is an infographic about human papillomavirus.

Contact: Kobi Print
kobi.print@sydney.edu.au
61-481-012-729
University of Sydney

Oncogenic lncRNA FAL1

Oncogenic lncRNA FAL1
This image depicts an oncogenic lncRNA FAL1 (the dragon) dysregulating gene transcription and promoting tumorigenesis. FAL1 stabilizes BMI1 (the stone) by associating with it (the dragon twine around ...

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Keytruda (3 of 3)

Keytruda (3 of 3)
The immune system is able to resume its attack by the white blood cells, shrinking the tumors.

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-794-2262
University of California - Los Angeles Health Sciences

Keytruda (2 of 3)

Keytruda (2 of 3)
The new drug blocks the protein and breaks down the protective shield.

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-794-2262
University of California - Los Angeles Health Sciences

Keytruda (1 of 3)

Keytruda (1 of 3)
White blood cells of our immune system attempt to attack a deadly melanoma cancer tumor, but are blocked by a protein that raises up from the cancer cell like a shield.

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-794-2262
University of California - Los Angeles Health Sciences

Macrophages

Macrophages
In an inflammatory environment (left) and normal environment (right) macrophages (green) engulf dead cells (pink).

Contact: Salk Communications
press@salk.edu
Salk Institute

Mouse Model UBC13 Enzyme

Mouse Model UBC13 Enzyme
This image depicts a tumor with reduced levels of enzyme UBC13 (top) and a control tumor (bottom) that has spread to the lungs.

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Sabotaging a Cancer Cell

Sabotaging a Cancer Cell
In this image, lupus antibodies penetrate a nucleus.

Contact: Vicky Agnew
203-785-7001
Yale University

Activated Oncogene Spurs Production of Hydrogen Peroxide

Activated Oncogene Spurs Production of Hydrogen Peroxide
When the oncogene H-RAS is activated in a cell (right panel), the cell begins to produce hydrogen peroxide (tagged with a red fluorescent marker), a form of reactive oxygen species. It's the first ...

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Raman Spectrometer for Cancer Detection

Raman Spectrometer for Cancer Detection
A team led by researchers at Guangdong Medical College in China has demonstrated the potential of a new, non-invasive method to screen for prostate cancer, a common type of cancer in men worldwide.

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
American Institute of Physics

HICCC Building

HICCC Building
This is the Herbert Irving Comprehensive Cancer Center building.

Contact: Lucky Tran
lt2549@columbia.edu
212-305-3689
Columbia University Medical Center

HICCC Research

HICCC Research
Research at the Herbert Irving Comprehensive Cancer Center.

Contact: Lucky Tran
lt2549@columbia.edu
212-305-3689
Columbia University Medical Center

Nf-Trip Suppresses Tumor Growth of HCC Orthotopic Model

Nf-Trip Suppresses Tumor Growth of HCC Orthotopic Model
This image proves that Nf-Trip suppresses tumor growth of HCC orthotopic model.

Contact: Han Bin Oh
ohanvin@ibs.re.kr
82-428-788-182
Institute for Basic Science

Nf-Trip for Hepatocellular Carcinoma Targeted Therapy

Nf-Trip for Hepatocellular Carcinoma Targeted Therapy
This is a illustration to explain about Nf-Trip for Hepatocellular Carcinoma (HCC) targeted therapy.

Contact: Han Bin Oh
ohanvin@ibs.re.kr
82-428-788-182
Institute for Basic Science

RUNK Proteins and Fanconi Anemia Factor

RUNK Proteins and Fanconi Anemia Factor
RUNX proteins (red) facilitate the recruitment of Fanconi anemia factor (green) to sites of DNA damage.

Contact: Kimberley Wang
kimberley.wang@nus.edu.sg
National University of Singapore

DNA Damage

DNA Damage
Persistent DNA damage, visualized by gammaH2AX staining (red dots), in hematopoietic stem cells could lead to leukemia.

Contact: Kimberley Wang
kimberley.wang@nus.edu.sg
National University of Singapore

Roving Receptors (1 of 2)

Roving Receptors (1 of 2)
Duke University's David Sherwood and his team are using live-cell imaging to probe living cells to see how they find their way to new tissues and organs in the body. In these time-lapse videos of an ...

Contact: Robin Ann Smith
ras10@duke.edu
919-681-8057
Duke University

Roving Receptors (2 of 2)

Roving Receptors (2 of 2)
Once the receptors locate the signal, they stay put in the region of the cell membrane that is closest to its source.

Contact: Robin Ann Smith
ras10@duke.edu
919-681-8057
Duke University

APC Ceta Catenin Colon

APC Ceta Catenin Colon
This is mouse colon tissue stained for APC (red), b-catenin (green), and nuclei (blue).

Contact: Brendan M. Lynch
blynch@ku.edu
785-864-8855
University of Kansas

Exosome Deployed

Exosome Deployed
Male fruit flies deploy exosomes to alter the mating behavior of females. Shown here, a close-up view (right) of the female reproductive tract (left) reveals a green exosome (arrow) on the surface.

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

Botox Injection

Botox Injection
This image shows cells from the anterior (left) and posterior (right) halves of the stomach of mice with cancer. Only the anterior stomach half was injected with Botox®.

Contact: Lucky Tran
lt2549@cumc.columbia.edu
212-305-3689
Columbia University Medical Center

Botox Mechanism

Botox Mechanism
Botox® is taken in by the nerves, where it prevents the release of neurotransmitters.

Contact: Lucky Tran
lt2549@cumc.columbia.edu
212-305-3689
Columbia University Medical Center

Stomach Cells

Stomach Cells
This image shows stomach cells (red) growing with nerve cells (fluorescent green) in a lab culture dish.

Contact: Lucky Tran
lt2549@cumc.columbia.edu
212-305-3689
Columbia University Medical Center

Nanoparcticles Producing Logical Calculations

Nanoparcticles Producing Logical Calculations
This illustration shows nanoparcticles producing logical calculations.

Contact: Alexandra O. Borissova
borissova@phystech.edu
7-926-376-1175
Moscow Institute of Physics and Technology

Cells Passing Through EMT Chip

Cells Passing Through EMT Chip
As cells undergoing the epithelial-mesenchymal transition move from left to right through the EMT chip, those expressing mesenchymal markers (red) break away and move independently from other cells, ...

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital

Leukemia Cell Image

Leukemia Cell Image
A leukemia cell coated with antibody is marked for destruction by activated natural killer cells.

Contact: Ellin Kavanagh
ekavanagh@chla.usc.edu
Children's Hospital Los Angeles

The Inner Workings of Scalpel

The Inner Workings of Scalpel
Each dot represents a short sequence of DNA from the reads mapped to a gene. The red path spells out the normal version of the gene, while the yellow path spells out a truncated path with the indel. ...

Contact: Jaclyn Jansen
jjansen@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

The Dangers of Indels

The Dangers of Indels
The letters in the human genome carry instructions to make proteins, via a three-letter code. Each trio spells out a word, and the words are strung together in a sentence to build a specific protein. ...

Contact: Jaclyn Jansen
jjansen@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

MD Anderson Teams up with Industry Leader to Improve Targeted Therapies in Metastatic Disease

MD Anderson Teams up with Industry Leader to Improve Targeted Therapies in Metastatic Disease
The University of Texas MD Anderson Cancer Center announced an alliance with Boston-based Foundation Medicine and the opening of a randomized-controlled trial called IMPACT2 to determine whether ...

Contact: William Fitzgerald
wbfitzgerald@mdanderson.org
713-792-9518
University of Texas M. D. Anderson Cancer Center

Imaging Cancer Cell Invasion (2 of 2)

Imaging Cancer Cell Invasion (2 of 2)
Cancer cells advance across a microchip designed to be an obstacle course for cells. The device sheds new light on how cancer cells invade and could be used to test drugs aimed at preventing cancer ...

Contact: Kevin Stacey
kevin_stacey@brown.edu
401-863-3766
Brown University

Imaging Cancer Cell Invasion (1 of 2)

Imaging Cancer Cell Invasion (1 of 2)
Cancer cells advance across a microchip designed to be an obstacle course for cells. The device sheds new light on how cancer cells invade and could be used to test drugs aimed at preventing cancer ...

Contact: Kevin Stacey
kevin_stacey@brown.edu
401-863-3766
Brown University

Skeletal Abnormalities in Neurofibromatosis

Skeletal Abnormalities in Neurofibromatosis
Mice missing the gene neurofibromin in bone cells have more non-calcified bone (osteoid), shown in pink, compared to normal mice. In this image, calcified bone is black and bone-forming osteoblasts ...

Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center

Deaths Rise with Shift from In-Hospital to Outpatient Procedures for Urology Surgeries

Deaths Rise with Shift from In-Hospital to Outpatient Procedures for Urology Surgeries
Jesse D. Sammon, D.O., a researcher at Henry Ford's Vattikuti Urology Institute and lead author of the study discusses deaths rise with shift from in-hospital to outpatient procedures for common ...

Contact: Dwight Angell
dwight.angell@hfhs.org
313-876-8709
Henry Ford Health System

Ethiopian Medical Students Gather and Discuss around Patient Bed in Hospital

Ethiopian Medical Students Gather and Discuss around Patient Bed in Hospital
Scientists and physicians in low- and middle-income countries should build on existing HIV research to study and treat chronic conditions, according to global health experts.

Contact: Jeff Gray
Jeffrey.Gray@nih.gov
301-496-2075
NIH/Fogarty International Center

Common Bacteria Shrink Solid Tumors

Common Bacteria Shrink Solid Tumors
Injections of a genetically modified strain of the bacteria Clostridium novyi can shrink solid tumors. This video relates to a paper that appeared in the Aug. 13, 2014, issue of Science ...

Contact: Science Press Package
scipak@aaas.org
202-326-6440
American Association for the Advancement of Science

Tracking a Particle

Tracking a Particle
The jerky movement of a particle within the cytoplasm does resemble thermal diffusion, 'but it's just not the case,' says Guo.

Contact: Caroline Perry
cperry@seas.harvard.edu
617-496-1351
Harvard University

ATP-driven Transport

ATP-driven Transport
In comparison to those in normal cells (top row), fluorescent proteins in ATP-depleted cells (bottom row) took much longer to diffuse from one side of a cell to another—the distance indicated by...

Contact: Caroline Perry
cperry@seas.harvard.edu
617-496-1351
Harvard University

Movement in the Cytoplasm

Movement in the Cytoplasm
Within the cytoplasm, fluctuating forces enhance the intracellular transport of proteins and organelles.

Contact: Caroline Perry
cperry@seas.harvard.edu
617-496-1351
Harvard University

Brain Tumor Blood Vessels

Brain Tumor Blood Vessels
This microscopic view of a section of mouse brain shows tiny clusters of tumor cells growing along existing brain blood vessels.

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System

Pathologic and MRI Evidence of Blood-Brain-Barrier Disruption

Pathologic and MRI Evidence of Blood-Brain-Barrier Disruption
Two minimally invasive needle electrodes with 1 mm active length were spaced 4.0 mm apart and inserted into the right cerebral hemisphere 1.5 mm beneath the surface of the dura. A burst of 200, 500 ns...

Contact: Philly Lim
mllim@wspc.com
65-646-65775
World Scientific

<I>C. novyi</I> (2 of 2)

C. novyi (2 of 2)
This is a hematoxylin and eosin stain of a C. novyi-NT treated dog tumor. Lighter pink areas areas denote tumor necrosis next to areas with viable tumor cells. Black patches are calcified areas...

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

<I>C. novyi</I> (1 of 2)

C. novyi (1 of 2)
This is a gram stain of C. novyi-NT germination in a dog tumor. The darker rod-shaped bacteria are visible throughout the image.

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Cancer Cell with Nanoparticles

Cancer Cell with Nanoparticles
This is a c cancer cell containing the nanoparticles. The nanoparticles are colored green, and have entered the nucleus, which is the area in blue.

Contact: Tom Kirk
tdk25@cam.ac.uk
01-223-768-377
University of Cambridge

Chemoradiotherapy of Glioblastoma

Chemoradiotherapy of Glioblastoma
This is a diagram showing the composition of the nanosphere.

Contact: Tom Kirk
tdk25@cam.ac.uk
01-223-768-377
University of Cambridge

Activated mTORC1 Signaling

Activated mTORC1 Signaling
Activated mTORC1 signaling (top) correlates with increased FGF21 expression (below) in human liver tumor.

Contact: Olivia Poisson
olivia.poisson@unibas.ch
University of Basel

Lungs

Lungs
In lungs lacking a 'halt' signal from regulatory T cells, (right) killer T cells and other pathogen fighters accumulate (purple rings) in an excessive immune system response, creating lung ...

Contact: Salk Communications
press@salk.edu
Salk Institute

Schematic of CRISPR vs. HPV

Schematic of CRISPR vs. HPV
Using CRISPR to silence the E6 gene in Human Papilloma Virus, Duke researchers were able to re-start the cervical carcinoma cell's natural self-destruct mechanisms, including the gene p53. Similar ...

Contact: Karl Bates
karl.bates@duke.edu
919-681-8054
Duke University

A*Star's IMB Finds Biomarker for Potential Early Detection of Ovarian Cancer

A*Star's IMB Finds Biomarker for Potential Early Detection of Ovarian Cancer
This image depicts a mouse ovary is encapsulated by a single layer of cells called ovary surface epithelium (indicated by black arrows). These cells are long believed to be the cancer cell of origin ...

Contact: Vanessa Loh
vanessa_loh@a-star.edu.sg
656-826-6395
Biomedical Sciences Institutes (BMSI)

Findings at A*Star's Bioinformatics Institute Hold Potential for Personalised Treatment of Major Typ

Findings at A*Star's Bioinformatics Institute Hold Potential for Personalised Treatment of Major Typ
This is a representative crystal structure of the Chk2 protein after computational modelling and simulation of molecular dynamics. The coloured spheres represent the locations of mutations, which BII ...

Contact: Vanessa Loh
vanessa_loh@a-star.edu.sg
656-826-6395
Biomedical Sciences Institutes (BMSI)

Breast Cancer Cell

Breast Cancer Cell
Mammary cells found during pregnancy that express integrin beta3 (CD61) act as stem cells, capable of reconstituting a new mammary gland in mice. This property may be to blame for the more aggressive ...

Contact: Yadira Galindo
ygalindo@ucsd.edu
619-543-6163
University of California - San Diego

Galectin-Lacking Brain Tumor Cells Dying

Galectin-Lacking Brain Tumor Cells Dying
In mice whose brain tumor cells (in green) couldn't make galectin-1, the body's immune system was able to recognize and attack the cells, causing them to die. In this microscope image, the orange ...

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System

Liver Regeneration

Liver Regeneration
This image shows liver cells regenerated in mice treated with a new drug (right) compared with a control group (center) after partial liver removal. Healthy liver cells are shown at left.

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

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