Curaxins: Small Molecules Pack Big Punch for Cancer Therapy (6 of 6)
Chemotherapeutic drugs/ionizing radiation and curaxins interact with cellular DNA. However the former cause DNA breaks and the latter change architecture of DNA and chromatin without actual breaks. ...

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Curaxins: Small Molecules Pack Big Punch for Cancer Therapy (5 of 6)
The target of curaxins, the FACT complex, is highly expressed in tumor cells, but not in normal cells. This is an enlarged image of a fragment of tissue microarray. Sections of biopsies of lung tumor...

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American Association for the Advancement of Science

Curaxins: Small Molecules Pack Big Punch for Cancer Therapy (4 of 6)
This image shows the death of curaxin treated tumor cell. Immunofluorescent image of non-fixed cells. Red -– red fluorescent protein (RFP) tagged histone H2B. Green -– green fluorescent protein (GFP) ...

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Curaxins: Small Molecules Pack Big Punch for Cancer Therapy (3 of 6)
Similar to the previous image, except these cells tried to divide several times and all unsuccessfully. This led to the shape of its nucleus. This image relates to a paper that appeared in the Aug. ...

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American Association for the Advancement of Science

Curaxins: Small Molecules Pack Big Punch for Cancer Therapy (2 of 6)
A curaxin treated tumor cell is to divide. Two nuclei incompletely separated during mitosis due to the problem with chromatin in this cell. We can see extreme chromatin condensation around nucleoli ("...

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scipak@aaas.org
202-326-6440
American Association for the Advancement of Science

Curaxins: Small Molecules Pack Big Punch for Cancer Therapy (1 of 6)
A curaxin treated tumor cell is unable to divide. Two nuclei incompletely separated during mitosis due to the problem with chromatin in this cell. We can see extreme chromatin condensation around ...

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202-326-6440
American Association for the Advancement of Science

Designer T Cells Attack Leukemia
University of Pennsylvania cancer investigators Carl June, David Porter, Bruce Levine and Michael Kalos discuss their work using genetically modified T cells for the treatment of patients with chronic...

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American Association for the Advancement of Science

The Genomic Landscape of Head and Neck Cancer
This is a saggital MRI image demonstrating the anatomic regions that comprise head and neck cancer. This image relates to an article that appeared in the July 28, 2011, issue of Science Express...

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American Association for the Advancement of Science

Tumor-Associated Mutations Affect Telomeres (2 of 2)
This image shows ATRX protein staining in brown. ATRX protein is clearly is missing from the nuclei of the cancer cells (here stained blue) which are here surrounding a normal blood vessel whose cells...

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scipak@aaas.org
202-326-6440
American Association for the Advancement of Science

Tumor-Associated Mutations Affect Telomeres (1 of 2)
This image, from the same case, shows highly abnormal fluorescent signals from cancer cell telomeres (red) that are indicative of the ALT telomere maintenance phenotype. All cell nuclei here are ...

Contact: Science Press Package
scipak@aaas.org
202-326-6440
American Association for the Advancement of Science