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Showing releases 1-25 out of 1213.

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Public Release: 30-Jan-2015
Nature Communications
Hot on the trail of the hepatitis-liver cancer connection
Using whole genomic sequencing, scientists from RIKEN in Japan have for the first time demonstrated the profound effect that chronic hepatitis infection and inflammation can have on the genetic mutations found in tumors of the liver, potentially paving the way to a better understanding of the mechanisms through which these chronic infections can lead to cancer.

Contact: Jens Wilkinson
jens.wilkinson@riken.jp
81-484-621-225
RIKEN

Public Release: 30-Jan-2015
Science of the Total Environment
Arsenic stubbornly taints many US wells, say new reports
Naturally occurring arsenic in private wells threatens people in many US states and parts of Canada, according to a package of a dozen scientific papers to be published next week. The studies, focused mainly on New England but applicable elsewhere, say private wells present continuing risks due to almost nonexistent regulation in most states, homeowner inaction and inadequate mitigation measures.
NIH/National Institute of Environmental Health Sciences Superfund Research Program

Contact: Kevin Krajick
kkrajick@ei.columbia.edu
212-854-9729
The Earth Institute at Columbia University

Public Release: 30-Jan-2015
PLOS ONE
Moffitt study find loss of certain protein is associated with poor prognosis in breast, lung cancer
Moffitt Cancer Center researchers have found that breast and lung cancer patients who have low levels of a protein called tristetraprolin have more aggressive tumors and a poorer prognosis than those with high levels of the protein. Their study was published in the Dec. 26 issue of PLoS One.
NIH/National Cancer Institute

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 30-Jan-2015
Nature Communications
Scientists home in on reasons behind cancer drug trial disappointment
Scientists have discovered a 'hidden' mechanism which could explain why some cancer therapies which aim to block tumor blood vessel growth are failing cancer trials. The same mechanism could play the role in the bacterial or viral septic shock -- e.g. in Ebola fever -- by destabilizing the blood vessels.

Contact: Dr. Pipsa Saharinen
pipsa.saharinen@helsinki.fi
358-504-486-361
University of Helsinki

Public Release: 30-Jan-2015
EBioMedicine
UTSW study links deficiency of cellular housekeeping gene with aggressive forms of breast cancer
UT Southwestern Medical Center scientists have identified a strong link between the most aggressive type of breast cancer and a gene that regulates the body's natural cellular recycling process, called autophagy.
National Institutes of Health, Cancer Prevention and Research Institute of Texas

Contact: Debbie Bolles
debbie.bolles@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 30-Jan-2015
Neurosurgery
Fluorescent dyes 'light up' brain cancer cells, reports Neurosurgery
Two new fluorescent dyes attracted to cancer cells may help neurosurgeons more accurately localize and completely resect brain tumors, suggests a study in the February issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health

Public Release: 29-Jan-2015
Developmental Cell
Identified the mechanism that controls localization of protein Rac1 in the cell nucleus
The prolonged presence of Rac1 in the nucleus leads to changes in nuclear morphology that are important in cell migration.

Contact: AInhoa Iriberri
airiberri@cnic.es
34-610-295-556
Centro Nacional de Investigaciones Cardiovasculares

Public Release: 29-Jan-2015
Science
New clues about a brain protein with high affinity for Valium
Valium, one of the best known antianxiety drugs, produces its calming effects by binding with a particular protein in the brain. But the drug has an almost equally strong affinity for a completely different protein. New studies revealing atomic level details of this secondary interaction might offer clues about Valium's side effects and point the way to more effective drugs.
National Institutes of Health, New York Structural Biology Center, DOE/Office of Science

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory

Public Release: 29-Jan-2015
American Journal of Human Genetics
Parkinson's gene linked to lung cancer
Researchers at the Medical College of Wisconsin, in collaboration with other colleagues of the Genetic Epidemiology of Lung Cancer Consortium, have identified a gene that is associated with lung cancer.

Contact: Maureen Mack
mmack@mcw.edu
414-955-4744
Medical College of Wisconsin

Public Release: 29-Jan-2015
PLOS Medicine
New minimally invasive test identifies patients for Barrett's esophagus screening
A new minimally invasive cell sampling device coupled with assessment of trefoil factor 3 expression can be used to identify patients with reflux symptoms who warrant endoscopy to diagnose Barrett's esophagus, according to a study published by Rebecca Fitzgerald and colleagues from the MRC Cancer Unit, UK, in this week's PLOS Medicine.
Cancer Research UK

Contact: Maya Sandler
medicinepress@plos.org
PLOS

Public Release: 29-Jan-2015
Cancer Research
New potential therapeutic strategy against a very aggressive infant bone cancer
Researchers at the Bellvitge Biomedical Research Institute, led by Oscar Martínez Tirado participated in an international study which suggests inhibition of Sirtuin1 protein as a future treatment option for metastatic Ewing sarcoma. The results of the study were published in the journal Cancer Research.

Contact: Arantxa Mena
amena@idibell.cat
0034-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 29-Jan-2015
Journal of Thoracic Oncology
Testing for EGFR mutations and ALK rearrangements is cost-effective in NSCLC
Multiplexed genetic screening for epidermal growth factor receptor and anaplastic lymphoma kinase gene rearrangements and subsequent biomarker-guided treatment is cost-effective compared with standard chemotherapy treatment without any molecular testing in the metastatic non-small cell lung cancer setting in the United States.

Contact: Murry Wynes
Murry.Wynes@iaslc.org
720-325-2945
International Association for the Study of Lung Cancer

Public Release: 29-Jan-2015
Cell Cycle
Fox Chase researchers reveal how pancreatic cancer cells sidestep chemotherapy
Research led by Timothy J. Yen, Ph.D., Professor at Fox Chase Cancer Center, reveals that one reason pancreatic cancer can be so challenging to treat is because its cells have found a way to sidestep chemotherapy. They hijack the vitamin D receptor, normally associated with bone health, and re-purposed it to repair the damage caused by chemotherapy.

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center

Public Release: 29-Jan-2015
Nucleic Acids Research
CNIO researchers broaden the catalogue of biological chimeras for the study of the genome
The team led by Alfonso Valencia gathers 29,000 biological chimeras from eight species, including humans, mice and yeast. The catalog is a very valuable source of information for cancer research, and it could reveal new markers and potential targets for the development of new cancer drugs.

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 28-Jan-2015
Proceedings of the National Academy of Sciences
Game theory explains social interactions of cancer cells
Researchers at the University of Basel and the University of East Anglia were able to predict the interactions of cancer cells using game theory. Their results have been published by the scientific journal PNAS.

Contact: Reto Caluori
reto.caluori@unibas.ch
41-612-672-495
University of Basel

Public Release: 28-Jan-2015
PLOS ONE
Earlier menopause linked to everyday chemical exposures
Women whose bodies have high levels of chemicals found in plastics, personal-care products, common household items and the environment experience menopause two to four years earlier than women with lower levels of these chemicals, according to a new study at Washington University School of Medicine in St. Louis. The findings are reported online Jan. 28 in the journal PLOS ONE.
National Institutes of Health

Contact: Diane Duke Williams
williamsdia@wustl.edu
314-286-0111
Washington University School of Medicine

Public Release: 28-Jan-2015
Oncotarget
Schoolgirl comment points to antibiotics as new cancer treatments
A way to eradicate cancer stem cells, using the side-effects of commonly used antibiotics, has been discovered by a University of Manchester researcher following a conversation with his young daughter.
Breast Cancer Breakthrough

Contact: Jamie Brown
Jamie.brown@manchester.ac.uk
44-016-127-58383
University of Manchester

Public Release: 28-Jan-2015
Nature Communications
New method for identifying most aggressive childhood cancers
A research group at Lund University in Sweden has found a new way to identify the most malignant tumors in children. The method involves studying genetic 'micro-variation,' rather than the presence of individual mutations.

Contact: David Gisselsson Nord
david.gisselsson_nord@med.lu.se
46-733-914-036
Lund University

Public Release: 28-Jan-2015
Nature
NIH-funded study uncovers molecular alterations in head and neck cancers
A new study shows genomic differences in head and neck cancers caused by infection with the human papillomavirus. In addition, researchers have uncovered new smoking-related cancer subtypes and potential new drug targets, and found numerous genomic similarities with other cancer types. Together, this study's findings may provide detailed explanations of how HPV infection and smoking play roles in head and neck cancer risk and disease development, and offer potential diagnostic and treatment directions.
National Institutes of Health

Contact: Steven Benowitz
Steven.Benowitz@nih.gov
301-402-0911
NIH/National Human Genome Research Institute

Public Release: 28-Jan-2015
Journal of the American College of Radiology
California breast density law slow to have an impact
Ten months after California legislators enacted a controversial law mandating that radiologists notify women if they have dense breast tissue, UC Davis researchers have found that half of primary care physicians are still unfamiliar with the law and many don't feel comfortable answering breast density-related questions from patients.

Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System

Public Release: 28-Jan-2015
Molecular Nutrition and Food Research
Green tea ingredient may target protein to kill oral cancer cells
A compound found in green tea may trigger a cycle that kills oral cancer cells while leaving healthy cells alone, according to Penn State food scientists. The research could lead to treatments for oral cancer, as well as other types of cancer.
American Institute for Cancer Research

Contact: Matt Swayne
mls29@psu.edu
814-865-9481
Penn State

Public Release: 28-Jan-2015
PLOS Computational Biology
Dartmouth investigators conduct systematic testing of deimmunized biotherapeutic agents
By establishing protein design algorithms that simultaneously optimize drug candidates for both decreased immunogenic epitope content and high level stability and activity, researchers have established a novel testing platform. Published in PLOS Computational Biology, the paper, titled, 'Mapping the Pareto Optimal Design Space for a Functionally Deimmunized Biotherapeutic Candidate,' guides biotechnologists toward protein designs that function appropriately using sophisticated design algorithms.
National Institutes of Health

Contact: Kirk Cassels
kirk.A.Cassels@Hitchcock.org
603-653-6177
The Geisel School of Medicine at Dartmouth

Public Release: 28-Jan-2015
Nature
UNC researcher co-leads effort to map genomic changes in head and neck cancer
A study co-led by a UNC Lineberger Comprehensive Cancer Center researcher has identified genomic changes in head and neck cancers linked to the sexually transmitted disease HPV -- the latest finding of a collaborative scientific effort designed to map out the genomic changes driving cancer.
NIH/National Cancer Institute, NIH/National Human Genome Research Institute

Contact: Laura Oleniacz
laura_oleniacz@med.unc.edu
919-812-0621
University of North Carolina Health Care

Public Release: 28-Jan-2015
Nature
Large study catalogs genetic culprits in head and neck cancers
Scientists publish the first comprehensive catalog of genetic mutations and other abnormal changes found in 279 cancers of the head and neck, identifying several broken molecular pathways that might be targeted by existing and future cancer drugs.
National Institutes of Health

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute

Public Release: 28-Jan-2015
Cancer Research
Moffitt researchers discover protein pathway involved in lung cancer metastasis
Smoking is the leading cause of lung cancer, and it is estimated that more than 159,000 people in the United States died from the disease last year. Most of these deaths were because the cancer had spread to other organ sites. Following their recent discovery of a protein pathway, Moffitt Cancer Center researchers are one step closer to understanding how lung cancer cells metastasize.
NIH/National Cancer Institute

Contact: Kim Polacek
Kim.Polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Showing releases 1-25 out of 1213.

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