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Showing releases 1-25 out of 1136.
Public Release: 2-Dec-2012
 Nature GeneticsCell surface transporters exploited for cancer drug delivery According to Whitehead Institute researchers, a protein known as monocarboxylate transporter 1 (MCT1), which is highly expressed in a subset of metabolically altered cancer cells, is needed for the entry of the investigational cancer drug 3-bromopyruvate (3-BrPA) into malignant cells. This work may open a new avenue for cancer therapeutic research, as other transport molecules have already been identified on the surface of certain cancer cells. 
National Institutes of Health, David H. Koch Institute for Integrative Cancer Research, Jane Coffin Childs Fund, National Science Foundation
Contact: Nicole Rura
Public Release: 2-Dec-2012
Nature GeneticsNew gene-sequencing tools offer clues to highest-risk form of a childhood cancer Using powerful gene-analysis tools, researchers have discovered mutations in two related genes, ARID1A and ARID1B, that are involved in the most aggressive form of the childhood cancer neuroblastoma. While these findings do not immediately improve clinical treatments, they identify a novel pathway that is defective in these cancers, a pathway that scientists can now study to develop potential new therapies.
National Institutes of Health, St. Baldrick's Foundation, Children's Oncology Group, and others
Contact: Rachel Salis-Silverman
Public Release: 2-Dec-2012
Nature Structural & Molecular BiologyScientists at Scripps Research Institute discover how 2 proteins help keep cells healthy Scientists at The Scripps Research Institute have determined how two proteins help create organelles, or specialized subunits within a cell, that play a vital role in maintaining cell health. This discovery opens the door for research on substances that could interfere with the formation of these organelles and lead to new therapies for cancer.
National Institutes of Health, Japan Science and Technology Agency
Contact: Mika Ono
Public Release: 2-Dec-2012
Nature GeneticsScientists find 'bully' genes in common childhood tumor In a genome sequencing study of 74 neuroblastoma tumors in children, scientists at the Johns Hopkins Kimmel Cancer Center and the Children's Hospital of Philadelphia found that patients with changes in two genes, ARID1A and ARID1B, survive only a quarter as long as patients without the changes. The discovery could eventually lead to early identification of patients with aggressive neuroblastomas who may need additional treatments.
NIH/National Cancer Institute, St. Baldrick's Foundation
Contact: Vanessa Wasta
Public Release: 1-Dec-2012
Cancer ResearchResearchers identify a mechanism for the transformation of colon polyps The causes underlying the development of certain types of common cancers have not yet been elucidated. In order to better determine the origin and the sequence of events responsible for the onset of colon cancer, the teams led by Thanos Halazonetis and Stylianos Antonarakis, professors at the UNIGE, Switzerland, have sequenced the DNA of biopsied tissue from colon polyps. The results show that these precancerous lesions have a specific profile. Contact: Thanos Halazonetis
Public Release: 1-Dec-2012
Journal of Thoracic OncologyLung cancer patients with pockets of resistance prolong disease control by 'weeding the garden' This study of 65 patients showed that continuing either crizotinib or erlotinib after the treatment of resistant pockets with focused radiation ("weeding the garden") was associated with more than half a year of additional cancer control.
NIH/National Cancer Institute
Contact: Garth Sundem
Public Release: 1-Dec-2012
Genes & DevelopmentX-ray analysis deciphers master regulator important for skin cancer With the X-ray vision of DESY's light source DORIS, a research team from Hamburg and Iceland has uncovered the molecular structure of a master regulator central to the most deadly form of skin cancer, melanoma. The results, published in the scientific journal "Genes & Development", throw new light on the workings of the so-called Microphthalmia-associated Transcription Factor MITF, that is not only connected to skin cancer, but also to a variety of hereditary diseases. Contact: Thomas Zoufal
Public Release: 30-Nov-2012
American Society of Clinical OncologyIntermountain Healthcare Cancer research provides possible road map for improving healthcare Given the right equipment, training and skill, an individual surgeon can expect to provide the best possible care on a consistent basis. But how do you get an entire system of surgeons -- each with his or her own ideas, backgrounds, and routines -- to provide that same level of care? New Research by Intermountain Healthcare's Oncology Clinical Program shows that it's possible to improve care across the board if you tackle the problem in a standardized way, relying on the best evidence available. Contact: Jess C. Gomez
Public Release: 29-Nov-2012
Proceedings of the National Academy of SciencesResearchers create a fly to study how a normal cell turns cancerous The wing of a fruit fly may hold the key to unraveling the genetic and molecular events that transform a normal cell into a cancerous one. The study, conducted on Drosophila melanogaster by scientists at the IRB Barcelona has reproduced each of the steps known to take place when a healthy cell turns cancerous. The researchers have thus provided an inexpensive and effective model that will allow to scrutinize the genes and molecules involved in each step. Contact: Sònia Armengou
Public Release: 29-Nov-2012
FASEB JournalNew genetic test detects early breast cancer and identifies future risk Breast cancer detection has improved, but more work remains to ensure accurate diagnosis, and to assess future risk. Researchers are developing a test of gene action that predicts cancer risk at first diagnosis, and into the future. This research in The FASEB Journal discusses how genetic switches, which are turned on and off in regular cellular development, can be analyzed in minute detail to determine the presence, or risk, of breast cancer growth. Contact: Cody Mooneyhan
Public Release: 29-Nov-2012
Cancer CellStudy sheds light on how pancreatic cancer begins Research led by scientists at the University of California, San Diego and UC San Francisco Schools of Medicine examined the tumor-initiating events leading to pancreatic cancer (also called pancreatic ductal adenocarcinoma or PDA) in mice. Their work, published on line November 29 in the journal Cancer Cell, may help in the search for earlier detection methods and treatments.
National Institutes of Health
Contact: Debra Kain
Public Release: 29-Nov-2012
Cancer CellStudy helps resolve debate about how tumors spread A team of scientists, led by researchers at the University of California, San Diego School of Medicine, has shown for the first time how cancer cells control the ON/OFF switch of a program used by developing embryos to effectively metastasize in vivo, breaking free and spreading to other parts of the body, where they can proliferate and grow into secondary tumors.
National Institutes of Health, American Cancer Society, Sidney Kimmel Foundation for Cancer
Contact: Scott LaFee
Public Release: 29-Nov-2012
Journal of Clinical OncologyDelayed treatment for advanced breast cancer has 'profound effect' Results from a recent study show women who wait more than 60 days to begin treatment for advanced breast cancer face significantly higher risks of dying than women who start therapy shortly after diagnosis. Contact: Marti Leitch
Public Release: 29-Nov-2012
Journal of Ovarian ResearchUnderstanding of the mechanisms of drug resistance to dual-agent chemotherapy in ovarian cancer A study published today in the open-access Journal of Ovarian Research provides novel information that further adds to clinicians' understanding of the mechanisms involved in the development of resistance to dual-agent chemotherapy. Contact: Hilary Glover
Public Release: 29-Nov-2012
StructureProteins that work at the ends of DNA could provide cancer insight New insights into a protein complex that regulates the very tips of chromosomes could improve methods of screening anti-cancer drugs. University of Illinois researchers determined the binding mechanism of proteins that protect and regulate telomeres, segments of repeating DNA units that cap the ends of chromosomes and a key target of cancer researchers.
American Cancer Society, Human Frontier Science Research Program
Contact: Liz Ahlberg
Public Release: 29-Nov-2012
Population Health ManagementDiabetics with cancer dangerously ignore blood sugar When people with Type 2 diabetes are diagnosed with cancer -- for which they are at higher risk -- they ignore their diabetes to focus on cancer. But high blood sugar is more likely to kill them. When they received diabetes education after a cancer diagnosis, however, they were more likely to monitor their blood sugar and had fewer visits to the emergency room, fewer hospital admissions and lower health care costs.
NIH/National Cancer Institute
Contact: Marla Paul
Public Release: 29-Nov-2012
Stress and Health Meditation with art therapy can change your brain and lower anxiety Cancer and stress go hand-in-hand, and high stress levels can lead to poorer health outcomes in cancer patients. The Jefferson-Myrna Brind Center of Integrative Medicine combined creative art therapy with a Mindfulness-based Stress Reduction program for women with breast cancer and showed changes in brain activity associated with lower stress and anxiety after the eight-week program. Their new study appears in the December issue of the journal Stress and Health. Contact: Lee-Ann Landis
Public Release: 29-Nov-2012
New England Journal of MedicineClinical trial delivers good results in leukemia patients Huntsman Cancer Institute researchers Michael Deininger, M.D., Ph.D., and Thomas O'Hare, Ph.D., were part of a team that found a potent oral drug, ponatinib, effective in patients who have developed resistance to standard treatments for chronic myeloid leukemia and Philadelphia chromosome positive acute lymphoblastic lymphoma. The New England Journal of Medicine released results of the trial today. Contact: Linda Aagard
Public Release: 29-Nov-2012
American Journal of PathologySt. Joseph's researchers identify gene involved in lung tumor growth Lung cancer researchers at St. Joseph's Hospital and Medical Center in Phoenix, Ariz., in collaboration with researchers at the Translational Genomics Research Institute and other institutions, have identified a gene that plays a role in the growth and spread of non-small cell lung cancer tumors, opening the door for potential new treatment options. Contact: Sara Baird
Public Release: 29-Nov-2012
Journal of Biological ChemistryActivating ALC1: With a little help from friends Chromatin remodeling -- the packaging and unpackaging of genomic DNA and its associated proteins -- regulates a host of fundamental cellular processes including gene transcription, DNA repair, programmed cell death as well as cell fate. In their latest study, scientists at the Stowers Institute for Medical Research are continuing to unravel the finicky details of how these architectural alterations are controlled.
NIH/National Institute of General Medical Sciences, Helen Nelson Medical Research Fund
Contact: Gina Kirchweger
Public Release: 28-Nov-2012
2012 Quality Care SymposiumStudies from 2012 Quality Care Symposium highlight findings in improving quality of cancer care Five additional studies to be presented at the 2012 Quality Care Symposium provide insight on how oncology practices can improve the quality of care they provide. The Symposium will take place Nov. 30 - Dec. 1, at the Manchester Grand Hyatt in San Diego. Contact: Aaron Tallent
Public Release: 28-Nov-2012
Journal of Biological ChemistryScripps Florida scientists uncover a novel cooperative effort to stop cancer spread Scientists from the Florida campus of The Scripps Research Institute have uncovered a group of what have been considered relatively minor regulators in the body that band together to suppress the spread of cancer from its primary site.
National Institutes of Health
Contact: Eric Sauter
Public Release: 28-Nov-2012
Journal of Lipid ResearchAnalysis of conflicting fish oil studies finds that omega-3 fatty acids still matter A new analysis helps to sort through conflicting findings from literally hundreds of studies on use of omega-3 fatty acids for heart disease. It concludes that they still matter; they do work; and that modern therapies for cardiovascular disease help to mask the benefits omega-3 consumption might otherwise provide.
National Institutes of Health, US Department of Agriculture
Contact: Donald Jump
Public Release: 28-Nov-2012
RadiologyExperts recommend closer scrutiny of radiation exposure from CT scans Amid increasing fear of overexposure to radiation from CT scans, a panel of experts has recommended more research on the health effects of medical imaging and ways to reduce unnecessary CT tests, as well as industry standardization of CT machines.
University of California
Contact: Dorsey Griffith
Public Release: 28-Nov-2012
Lancet OncologyResearchers report first success of targeted therapy in most common non-small cell lung cancer A new study by an international team of investigators led by Dana-Farber Cancer Institute scientists is the first to demonstrate that chemotherapy and a new, targeted therapy work better in combination than chemotherapy alone in treating patients with the most common genetic subtype of lung cancer.
AstraZeneca
Contact: Robbin Ray
Showing releases 1-25 out of 1136.
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