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Public Release: 19-Aug-2014
Neuro-Oncology
Markey researchers develop web-based app to predict glioma mutations
A new web-based program developed by University of Kentucky Markey Cancer Center researchers will provide a simple, free way for healthcare providers to determine which brain tumor cases require testing for a genetic mutation.
NIH/National Cancer Institute, Peter and Carmen Lucia Buck Training Program in Translational Clinical Oncology, University of Kentucky College of Medicine Physician Scientist Program

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky

Public Release: 19-Aug-2014
BJU International
Deaths rise with shift from in-hospital to outpatient procedures for urology surgeries
As hospitals have shifted an array of common urological surgeries from inpatient procedures to outpatient, potentially preventable deaths have increased following complications. Those were the primary findings of a new study led by Henry Ford Hospital researchers, who initially expected that improved mortality rates recently documented for surgery overall would also translate to commonly performed urologic surgeries. The opposite turned out to be true.

Contact: Dwight Angell
dwight.angell@hfhs.org
313-876-8709
Henry Ford Health System

Public Release: 19-Aug-2014
JAMA
Extended support helps patients stay smoke-free after hospital discharge
A Massachusetts General Hospital study in the August 20 issue of JAMA describes a program that increased the proportion of hospitalized smokers who successfully quit smoking after discharge by more than 70 percent. The system used interactive voice response technology to provide support and stop-smoking medication for three months after smokers left the hospital.
National Institutes of Health

Contact: Terri Ogan
togan@partners.org
617-726-0954
Massachusetts General Hospital

Public Release: 19-Aug-2014
Leukemia
Natural (born) killer cells battle pediatric leukemia
Researchers at Children's Hospital Los Angeles have shown that a select team of immune-system cells can be multiplied in the lab, creating an army of natural killer cells that can be used to destroy leukemia cells.
Alex's Lemonade Stand Foundation, Leukemia & Lymphoma Society, V-Foundation

Contact: Ellin Kavanagh
ekavanagh@chla.usc.edu
Children's Hospital Los Angeles

Public Release: 19-Aug-2014
Proceedings of the National Academy of Sciences
Biomarker in an aggressive breast cancer is identified
Northwestern University scientists have identified a biomarker strongly associated with basal-like breast cancer, a highly aggressive carcinoma that is resistant to many types of chemotherapy. The biomarker, a protein called STAT3, provides a smart target for new therapeutics designed to treat this often deadly cancer. Using patient data from The Cancer Genome Atlas, the researchers used bioinformatics techniques and found that a small number of genes are activated by STAT3 protein signaling in basal-like breast cancers but not in luminal breast cancers.
H Foundation, NIH/National Cancer Institute

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University

Public Release: 18-Aug-2014
Proceedings of the National Academy of Sciences
WSU researchers find crucial step in DNA repair
Scientists at Washington State University have identified a crucial step in DNA repair that could lead to targeted gene therapy for hereditary diseases such as 'children of the moon' and a common form of colon cancer. Such disorders are caused by faulty DNA repair systems that increase the risk for cancer and other conditions.
National Institute of Environmental Health Sciences

Contact: Michael Smerdon
smerdon@wsu.edu
509-335-6853
Washington State University

Public Release: 18-Aug-2014
JAMA Internal Medicine
Older patients with limited life expectancy still receiving cancer screenings
A substantial number of older patients with limited life expectancy continue to receive routine screenings for prostate, breast, cervical and colorectal cancer although the procedures are unlikely to benefit them.
Doris Duke Charitable Foundation

Contact: Katy Jones
katy_jones@med.unc.edu
919-962-3405
The JAMA Network Journals

Public Release: 18-Aug-2014
Nature Communications
Myc inhibition is an effective therapeutic strategy against most aggressive brain tumors
The Myc protein plays a key role in the development of several tumor types and its inhibition could therefore prove an effective therapy against many different cancers. Previous studies by this same VHIO group successfully blocked Myc through expression of an inhibitor, resulting in the eradication of lung tumors in preclinical models.

Contact: Amanda Wren
awren@vhio.net
34-695-207-886
Vall d´Hebron Institute of Oncology

Public Release: 18-Aug-2014
Molecular Carcinogenesis
Leukemia drug shows promise for skin, breast and other cancers
A leukemia drug called dasatinib shows promise for treating skin, breast and several other cancers, according to researchers at Loyola University Chicago Stritch School of Medicine.

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System

Public Release: 18-Aug-2014
Nature Nanotechnology
MIPT and RAS scientists made an important step towards creating medical nanorobots
Researchers at Moscow Institute of Physics and Technology and Russian Academy of Sciences made an important step towards creating medical nanorobots discovering a way of enabling them to produce logical calculations using a variety of biochemical reactions.

Contact: Alexandra O. Borissova
borissova@phystech.edu
7-926-376-1175
Moscow Institute of Physics and Technology

Public Release: 18-Aug-2014
Nature Materials
Massachussetts General-developed device monitors key step in development of tumor metastases
A microfluidic device developed at Massachusetts General Hospital may help study key steps in the process by which cancer cells break off from a primary tumor to invade other tissues and form metastases.
Damon Runyon Cancer Research Foundation, Howard Hughes Medical Institute, National Institutes of Health

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital

Public Release: 18-Aug-2014
Cancer Cell
New mouse model points to therapy for liver disease
In a paper published online in Cancer Cell, scientists at the University of California, San Diego School of Medicine describe a novel mouse model that closely resembles human NASH and use it to demonstrate that interference with a key inflammatory protein inhibits both the development of NASH and its progression to liver cancer.
National Institutes of Health, Superfund Basic Research Program, Daiichi Sankyo Foundation of Life Science and Grant-in-Aid for Scientific Research, Astellas Foundation for Research

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 17-Aug-2014
Nature Materials
Microchip reveals how tumor cells transition to invasion
A microscopic obstacle course of carefully spaced pillars enables researchers to observe cancer cells directly as they break away from a tumor mass and move more rapidly across the microchip. The device could be useful for testing cancer drugs and further research on the mechanics of metastasis. A paper describing research using the device is published in Nature Materials.
Damon Runyon Cancer Research Foundation, Howard Hughes Medical Institute, National Institutes of Health

Contact: Kevin Stacey
kevin_stacey@brown.edu
401-863-3766
Brown University

Public Release: 17-Aug-2014
Nature Methods
A shift in the code: New method reveals hidden genetic landscape
With three billion letters in the human genome, it seems hard to believe that adding or removing a base could have much of an effect on our health. Yet, such insertions and deletions can dramatically alter biological function. It is has been difficult to detect these mutations. Cold Spring Harbor Laboratory scientists have devised a new way to analyze genome sequences that pinpoints insertions and deletions in people with diseases such as autism, obsessive compulsive disorder, and Tourette syndrome.
National Institutes of Health, National Science Foundation, Cold Spring Harbor Laboratory, Stanley Institute for Cognitive Genomics, Simons Foundation

Contact: Jaclyn Jansen
jjansen@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Public Release: 15-Aug-2014
American Journal of Respiratory and Critical Care Medicine
Previous pulmonary disease linked to increased lung cancer risk in large study
Links between a number of common respiratory diseases and an increased risk of developing lung cancer have been found in a large pooled analysis of seven studies involving more than 25,000 individuals.

Contact: Nathaniel Dunford
ndunford@thoracic.org
American Thoracic Society

Public Release: 15-Aug-2014
Cancer Research
New ways to treat solid tumors
An international team of scientists has shown that an antibody against the protein EphA3, found in the micro-environment of solid cancers, has anti-tumor effects.

Contact: Rachael Fergusson
rachael.fergusson@monash.edu
61-399-034-841
Monash University

Public Release: 15-Aug-2014
Lancet Oncology
Guidelines can predict early menopause in child cancer survivors
Girls with cancer who are most likely to become infertile after treatment can be identified using guidelines developed almost 20 years ago, new research from the University of Edinburgh shows.
Medical Research Council

Contact: Jen Middleton
jen.middleton@ed.ac.uk
44-131-650-6514
University of Edinburgh

Public Release: 14-Aug-2014
Cancer Research
Protein found to block benefits of vitamin A cancer therapy
Retinoic acid is a form of vitamin A that is used to treat and help prevent the recurrence of a variety of cancers, but for some patients the drug is not effective. The reason for this resistance was unclear until this week when researchers from Virginia Commonwealth University Massey Cancer Center demonstrated that a protein known as AEG-1 blocks the effects of retinoic acid in leukemia and liver cancer.
National Institutes of Health, James S. McDonnel Foundation

Contact: Alaina Schneider
afschneider@vcu.edu
804-628-4578
Virginia Commonwealth University

Public Release: 14-Aug-2014
Cancer Research
NSAIDs benefit overweight breast cancer patients, study finds
Researchers have determined that postmenopausal overweight or obese breast cancer patients receiving hormone therapy as part of their treatment and who use nonsteroidal anti-inflammatory drugs such as aspirin or ibuprofen have significantly lower breast cancer recurrence rates and a sizable delay in time to cancer recurrence.
United States Department of Defense Breast Cancer Research Program, NIH/National Cancer Institute

Contact: Kimberly Atkins
kimberly.atkins@austin.utexas.edu
512-471-3151
University of Texas at Austin

Public Release: 14-Aug-2014
Nature Communications
Immune cell discovery could help to halt cancer spread
Melbourne researchers have revealed the critical importance of highly specialized immune cells, called natural killer cells, in killing melanoma cells that have spread to the lungs. These natural killer cells could be harnessed to hunt down and kill cancers that have spread in the body. The team, from the Walter and Eliza Hall Institute, also found natural killer cells were critical to the body's rejection of donor bone marrow transplants and in the runaway immune response during toxic shock syndrome.
Australian National Health and Medical Research Council, Menzies Foundation, Victorian Government

Contact: Liz Williams
williams@wehi.edu.au
61-428-034-089
Walter and Eliza Hall Institute

Public Release: 14-Aug-2014
Cell
Researchers identify a mechanism that stops progression of abnormal cells into cancer
Researchers from Boston University School of Medicine report that a tumor suppressor pathway, called the Hippo pathway, is responsible for sensing abnormal chromosome numbers in cells and triggering cell cycle arrest, thus preventing progression into cancer.
NIH/National Cancer Institute

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center

Public Release: 14-Aug-2014
JAIDS: Journal of Acquired Immune Deficiency Syndromes
Scientists detail urgent research agenda to address chronic disease toll
According to recommendations resulting from a multidisciplinary conference sponsored by the National Institutes of Health, scientists and physicians in low- and middle-income countries should build on existing HIV research to study and treat chronic conditions.

Contact: Jeff Gray
Jeffrey.Gray@nih.gov
301-496-2075
NIH/Fogarty International Center

Public Release: 14-Aug-2014
Nature Medicine
Novel treatment strengthens bones in genetic disease neurofibromatosis type-1
An enzyme therapy may prevent skeletal abnormalities associated with the genetic disorder neurofibromatosis type-1, Vanderbilt investigators have discovered. The researchers demonstrated in a mouse model of the disorder that the enzyme asfotase-alpha improves bone growth, mineralization and strength. Their findings are published in the August issue of Nature Medicine.
Children's Tumor Foundation, National Institutes of Health

Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center

Public Release: 14-Aug-2014
Cancer Research
New Irish research sheds light on how aspirin works to reduce cancer deaths
Researchers have discovered that women who had been prescribed aspirin regularly before being diagnosed with breast cancer are less likely to have cancer that spread to the lymph nodes than women who were not on prescription aspirin. These women are also less likely to die from their breast cancer.
Health Research Board (Ireland), Irish Cancer Society

Contact: Yolanda Kennedy
yokenned@tcd.ie
353-896-3551
Trinity College Dublin

Public Release: 14-Aug-2014
Cell
Inside the cell, an ocean of buffeting waves
Harvard-led researchers put forth a new model of the cytoplasm as a gel, not a liquid, and demonstrate that ATP-driven processes are indirectly responsible for transport within the cell. A measurement of the spectrum of forces exerted on the cytoplasm at any given time can provide a snapshot of the metabolic state of the cell.
National Institutes of Health, National Science Foundation, Netherlands Organization for Scientific Research, Hannah's Hope Fund

Contact: Caroline Perry
cperry@seas.harvard.edu
617-496-1351
Harvard University

Showing releases 1-25 out of 1250.

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