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Showing releases 1-25 out of 1382.

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Public Release: 27-Aug-2016
ESC Congress 2016
European Heart Journal
ESC launches novel paper on tackling cardiac toxicity of anticancer therapies
The European Society of Cardiology has launched a novel position paper, under the auspices of its Committee for Practice Guidelines, on tackling the cardiac toxicity of anticancer therapies. The cardio-oncology paper is published online today in European Heart Journal and on the ESC website.

Contact: ESC Press Office
European Society of Cardiology

Public Release: 26-Aug-2016
The Lancet Oncology
The first epigenetic test to diagnose tumors of unknown origin
An article published in The Lancet Oncology by Dr. Manel Esteller (IDIBELL) shows that it is possible to use a newly-developed epigenetic test called EPICUP® to find out what type of primary tumor is responsible for the metastasis in the patient in cancer of unknown primary cases, which will allow doctors to develop more specific treatments against it.

Contact: Gemma Fornons
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 26-Aug-2016
Nature Communications
Discovery of a novel Wnt inhibitor with potential to eradicate colorectal cancer stem cells
A team of researchers has announced the development of a novel small-molecule Wnt inhibitor named NCB-0846. Wnt signaling is a key pathway of cancer stem cell development. The inhibitor may provide a new therapy option for patients with drug-refractory colorectal cancer.

Contact: Jens Wilkinson

Public Release: 26-Aug-2016
Science of the Total Environment
UTA study finds air contamination near fracking sites result of operational inefficiencies
Chemists at the University of Texas at Arlington have published a new study that indicates that highly variable contamination events registered in and around unconventional oil and gas developments are the result of operational inefficiencies and not inherent to the extraction process itself.
Shimadzu Institute for Research Technologies, The University of Texas at Arlington/Collaborative Laboratories for Environmental Analysis and Remediation

Contact: Louisa Kellie
University of Texas at Arlington

Public Release: 26-Aug-2016
Cell Stem Cell
Researchers find a new way to identify and target malignant aging in leukemia
Researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified RNA-based biomarkers that distinguish between normal, aging hematopoietic stem cells and leukemia stem cells associated with secondary acute myeloid leukemia (sAML), a particularly problematic disease that typically afflicts older patients who have often already experienced a bout with cancer.
The Leukemia & Lymphoma Society, Moores Foundation, Mizrahi Family Foundation, Sanford Stem Cell Clinical Center, National Institutes of Health, Federico Foundation, UC San Diego AML Research Fund, and others

Contact: Scott LaFee
University of California - San Diego

Public Release: 25-Aug-2016
JAMA Oncology
Study examines financial conflict of interests among NCCN guideline authors
A new study published online by JAMA Oncology quantifies industry financial conflicts of interest (FCOIs) among authors of National Comprehensive Cancer Network (NCCN) guidelines, work that influences practice and defines drugs reimbursable by Medicare.

Contact: Laura Oleniacz
The JAMA Network Journals

Public Release: 25-Aug-2016
Insights on lung micro-environment explain why cancer spreads to the lungs
The same mechanisms that that prevent people from having an inflammatory response to harmless environmental exposures in day-to-day life could also all allow rogue cancer cells to spread to the lungs, according to new research from The Ohio State University Comprehensive Cancer Center. Researchers have discovered and described how the lung's unique underlying immune environment enables cancer to readily spread to the organ.
NIH/National Cancer Institute, NIH/National Institute of Allergy and Infectious Diseases, Li Jinyuan, The Tiens Charitable Foundation, Milstein Family Foundation, Wellcome Trust, Royal Society, Biotechnology and Biological Sciences Research Council

Contact: Amanda Harper
Ohio State University Wexner Medical Center

Public Release: 25-Aug-2016
JAMA Oncology
Study finds links between physicians setting cancer care guidelines and drug industry
University of North Carolina LIneberger Comprehensive Cancer Center researchers say the finding of a high prevalence of financial relationships among authors who helped develop a leading set of cancer treatment guidelines lays the foundation for future studies of whether the payments influenced the physician's clinical practice or guideline recommendations.

Contact: Laura Oleniacz
UNC Lineberger Comprehensive Cancer Center

Public Release: 25-Aug-2016
Cell Stem Cell
Study shows protein complex essential to creating healthy blood cells
A group of proteins best known for helping to activate all mammalian genes has been found to play a particularly commanding role in the natural development of specialized stem cells into healthy blood cells, a process known as hematopoiesis.

Contact: David March
NYU Langone Medical Center / New York University School of Medicine

Public Release: 25-Aug-2016
PLOS Computational Biology
Targeting low-oxygen patches inside lung cancer tumors could help prevent drug resistance
With the right treatment schedule, medications known as hypoxia-activated prodrugs (HAPs) could help prevent drug resistance in a subtype of lung cancer, according to a study published in PLOS Computational Biology.
National Science Foundation, National Institutes of Health

Contact: Jasmine Foo

Public Release: 25-Aug-2016
PLOS Computational Biology
Molecular flexibility shown to help pharmaceutical drugs bind to their targets
Scientists have discovered an alternative way to create a stronger binding between pharmaceutical drugs and the part of the body they are targeting -- a development that can be used to fight a variety of diseases, including breast cancer. The study published in PLOS Computational Biology shows that flexible molecules, instead of rigid ones, as previously thought, can bind more effectively to the proteins causing the disease.

Contact: Chia-en A. Chang

Public Release: 25-Aug-2016
New research reveals cancers need a 'perfect storm' of conditions to develop
Scientists have demonstrated for the first time the 'perfect storm' of conditions that cells need to start forming cancer, helping to explain why some organs are more susceptible to developing the disease.
National Institutes of Health, American Lebanese Syrian Associated Charities, Cancer Research UK

Contact: Simon Shears
Cancer Research UK

Public Release: 25-Aug-2016
Stem cell propagation fuels cancer risk in different organs
Experiments reveal the crucial contribution of stem cells to the origins of cancer in different organs.

Contact: Frannie Marmorstein
St. Jude Children's Research Hospital

Public Release: 25-Aug-2016
Oxygen can impair cancer immunotherapy in mice
Researchers have identified a mechanism in mice by which anticancer immune responses are inhibited within the lungs, a common site of metastasis for many cancers.
NIH/National Cancer Institute, NIH/National Institute of Allergy and Infectious Disease

Contact: NCI Press Office
NIH/National Cancer Institute

Public Release: 25-Aug-2016
Environmental Science
Latest research reveals sitting in traffic jams is officially bad for you
Pollution levels inside cars were found to be up to 40% higher while in traffic jams or at a red traffic light compared to free-flowing traffic conditions. Car windows closed with the fan/heating off in traffic is the best ventilation setting in traffic leading up to a 76% reduction in in-car pollutants. Also, safest setting is the air being circulated internally only by the fan without drawing in polluted air from outdoors.

Contact: Ashley Lovell
University of Surrey

Public Release: 25-Aug-2016
Current Opinions in Virology
In sub-Saharan Africa, cancer can be an infectious disease
University of Colorado Cancer Center researcher shows that mothers who contract malaria during pregnancy may have children with increased risk of Burkitt's lymphoma.
National Institutes of Health

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 25-Aug-2016
ACS Nano
Designing ultrasound tools with Lego-like proteins
Protein engineering techniques might one day lead to colorful ultrasound images of cells deep within our bodies.

Contact: Whitney Clavin
California Institute of Technology

Public Release: 25-Aug-2016
Chemistry of Materials
Important advance made with new approach to 'control' cancer, not eliminate it
Researchers have created a new drug delivery system that could improve the effectiveness of an emerging concept in cancer treatment -- to dramatically slow and control tumors on a long-term, sustained basis, not necessarily aiming for their complete elimination.
Medical Research Foundation of Oregon

Contact: Adam Alani
Oregon State University

Public Release: 25-Aug-2016
Leukemia & Lymphoma
Israeli lifestyle and environment may pose exceptional risks for Hodgkin's lymphoma
In Israel, the incidence of Hodgkin's lymphoma (HL) is among the highest in the world and has risen sharply over the past 45 years. Researchers found an association between being born in Israel and occurrence of HL, and an elevated risk of HL within one generation of moving to Israel. This could point to environmental causes such as exposures, diet, climate, social environment, and stress related to chronic regional conflict.
Israel Cancer Research Fund, Environment and Health Fund

Contact: Dov Smith
The Hebrew University of Jerusalem

Public Release: 25-Aug-2016
Cancer Research
Fused genes found in esophageal cancer cells offer new clues on disease mechanisms
Now, researchers from Case Western Reserve University School of Medicine have characterized structurally abnormal genes in esophageal adenocarcinoma, the findings of which could pave way for developing new biomarkers in this fatal disease.
National Institutes of Health, Case Western Reserve University

Contact: Marc Kaplan
Case Western Reserve University

Public Release: 25-Aug-2016
Researchers question process for reviewing coverage of 'off label' cancer drug use
In a paper published online by the Journal of the American Medical Association, UNC Lineberger Comprehensive Cancer Center physician-researchers raised concerns that there are inconsistencies between the reference guides, or compendia, that the Centers for Medicare and Medicaid Services uses to determine which drugs it will reimburse for off-label uses in cancer care.

Contact: Laura Oleniacz
UNC Lineberger Comprehensive Cancer Center

Public Release: 25-Aug-2016
Journal of Immunology
Researchers identify possible pathway to reboot immune system after bone-marrow transplant
New research has shown how a cell surface molecule, Lymphotoxin β receptor, controls entry of T-cells into the thymus; and as such presents an opportunity to understanding why cancer patients who undergo bone-marrow transplant are slow to recover their immune system.

Contact: Luke Harrison
University of Birmingham

Public Release: 25-Aug-2016
Immune system infighting explains pancreatic cancer's aggression
Conflict between cell types explains why the immune system struggles to recognize and attack pancreatic cancer.
German Research Foundation, National Pancreas Foundation, Pancreatic Cancer Action Network, Lustgarten Foundation, National Institutes of Health

Contact: Greg Williams
NYU Langone Medical Center / New York University School of Medicine

Public Release: 24-Aug-2016
Cancer Research
Smokers with newly discovered genetic markers have higher lung cancer risk
University of Hawai'i Cancer Center researchers discovered new genetic markers associated with a fast rate of nicotine metabolism, which potentially leads smokers to smoke more, thereby, increasing their risk for lung cancer.

Contact: Nana Ohkawa
University of Hawaii Cancer Center

Public Release: 24-Aug-2016
Nature Communications
Fateful evolution: New study improves accuracy of cancer diagnosis
In a new study, Carlo Maley, a researcher at Arizona State University's Biodesign Institute, uses evolutionary theory to make predictions about which BE patients will go on to develop cancer. The results, which appear in the current issue of the journal Nature Communications, point the way toward more accurate medical assessments for patients with BE and the development of early-warning beacons of disease known as biomarkers.

Contact: Joe Caspermeyer
Arizona State University

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