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Public Release: 5-May-2015
Practical Radiation Oncology
ASTRO issues guideline on definitive and adjuvant RT for locally advanced non-small cell lung cancer
The American Society for Radiation Oncology is issuing a new guideline, 'Definitive and adjuvant radiotherapy in locally advanced non-small cell lung cancer: An American Society for Radiation Oncology evidence-based clinical practice guideline.'

Contact: Michelle Kirkwood
American Society for Radiation Oncology

Public Release: 5-May-2015
Oral Oncology
Profiling approach to enable right lung cancer treatment match
Manchester researchers have tested a new way to genetically profile lung cancer samples, potentially allowing doctors to more easily identify the most appropriate treatment for patients.

Contact: Jamie Brown
University of Manchester

Public Release: 5-May-2015
Treating gum disease reduces prostate symptoms, CWRU researchers find
Treating gum disease reduced symptoms of prostate inflammation, called prostatitis, report researchers from Case Western Reserve University School of Dental Medicine and the Departments of Urology and Pathology at University Hospitals Case Medical Center.
Case Western Reserve University School of Dental Medicine and University Hospitals Case Medical Center

Contact: Susan Griffith
Case Western Reserve University

Public Release: 5-May-2015
Cell Reports
Breast cancer vaccines may work better with silicon microparticles
The effectiveness of cancer vaccines could be dramatically boosted by first loading the cancer antigens into silicon microparticles, report scientists from Houston Methodist and two other institutions in an upcoming Cell Reports.
US Department of Defense, National Institutes of Health, Cancer Prevention Research Institute of Texas

Contact: David Bricker
Houston Methodist

Public Release: 4-May-2015
Nature Medicine
Multiple types of resistance to new lung cancer drug identified
After identifying three different types of resistance to a promising investigational lung cancer drug in a phase 1 trial, a team of researchers led by Dana-Farber Cancer Institute scientists say new targeted inhibitors and combinations are urgently needed to stay ahead of tumors' constant and varied molecular shape-shifting.
NIH/National Cancer Institute, AstraZeneca

Contact: Anne Doerr
Dana-Farber Cancer Institute

Public Release: 4-May-2015
Nature Genetics
Decoding DNA's phonebook
A high-res genome catalog captures long-distance calls between DNA segments that may influence diseases.
Leukaemia and Lymphoma Research Fellowship, Framework Programme 7 Epigenesys Network of Excellence, Cancer Research UK, University College London, Okinawa Institute of Science and Technology, Wellcome Trust

Contact: Kaoru Natori
Okinawa Institute of Science and Technology (OIST) Graduate University

Public Release: 4-May-2015
Journal of Clinical Oncology
New screening technique could pick up twice as many women with ovarian cancer
A new screening method can detect twice as many women with ovarian cancer as conventional strategies, according to the latest results from the largest trial of its kind led by UCL. The new method detected cancer in 86 percent of women with invasive epithelial ovarian cancer, whereas the conventional test used in previous trials or in clinical practice would have identified fewer than half of these women (41 percent or 48 percent respectively).
UK Medical Research Council, Cancer Research UK, UK Department of Health, Eve Appeal

Contact: Harry Dayantis
University College London

Public Release: 4-May-2015
Discovered the sixth DNA base?
The director of the Epigenetics and Cancer Biology Program at IDIBELL, Manel Esteller, has published an article in Cell that suggests the existence of a sixth DNA base: the methyl-adenine that would regulate the expression of certain genes in eukaryotic cells and which could have a specific role in stem cells and in early stages of development.

Contact: Arantxa Mena
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 4-May-2015
Journal of Clinical Oncology
Racial differences in male breast cancer outcomes
While black and white men under age 65 diagnosed with early-stage breast cancer received similar treatment, blacks had a 76 percent higher risk of death than whites.
American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 4-May-2015
Nature Medicine
Study points to possible treatment for lethal pediatric brain cancer
Using brain tumor samples collected from children in the United States and Europe, an international team of scientists found that the drug panobinostat and similar gene regulating drugs may be effective at treating diffuse intrinsic pontine gliomas, an aggressive and lethal form of pediatric cancer.
National Institutes of Health, DIPG Collaborative, Cure Starts Now Foundation, Reflections of Grace Foundation, Smiles for Sophie Foundation, Cancer-Free Kids Foundation, Carly's Crusade Foundation and others

Contact: Christopher G. Thomas
NIH/National Institute of Neurological Disorders and Stroke

Public Release: 4-May-2015
Journal of Nuclear Medicine
Recurrence of prostate cancer detected earlier with innovative PSMA-ligand PET/CT
A recent study reported in The Journal of Nuclear Medicine compared use of the novel Ga-68-PSMA-ligand PET/CT with other imaging methods and found that it had substantially higher detection rates of prostate-specific membrane antigen in patients with biochemical recurrence after radical prostatectomy. It is especially noteworthy that this hybrid PSMA-ligand identified a large number of positive findings in the clinically important range of low PSA-values (<0.5ng/mL).
European Union Seventh Framework Program

Contact: Laurie Callahan
Society of Nuclear Medicine

Public Release: 4-May-2015
Proteomics identifies DNA repair toolbox
Various repair mechanisms help our cells to revert continuous damage to their DNA. If they fail, mutations accumulate that can lead to devastating diseases. DNA repair defects underlie predisposition to certain cancers and promote the transformation process in other spontaneous cancers. Using highly sensitive proteomic technologies, scientists of the Max Planck Institute of Biochemistry now report in the journal Science the first global analysis of the protein recruitment dynamics underlying a critical DNA repair pathway.

Contact: Anja Konschak
Max Planck Institute of Biochemistry

Public Release: 4-May-2015
Nature Genetics
Discovery could help reverse glucocorticoid resistance in some young leukemia patients
Researchers led by St. Jude Children's Research Hospital scientists have identified a mechanism that helps leukemia cells resist glucocorticoids, a finding that lays the foundation for more effective treatment of cancer and possibly a host of autoimmune diseases.
National Institutes of Health; American Recovery and Reinvestment Act supplement; American Lebanese Syrian Associated Charities

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

Public Release: 4-May-2015
Moderate exercise may make cancer treatments more effective, kinesiologist finds
Kansas State University kinesiology research offers encouraging information for cancer patients: A brisk walk or a slow jog on a regular basis may be the key to improved cancer treatments.
American Cancer Society

Contact: Brad Behnke
Kansas State University

Public Release: 4-May-2015
Youth just as likely to try e-cigarettes as smoking
Young people are just as likely to try electronic cigarettes as smoking, according to a new report from the Propel Centre for Population Health Impact at the University of Waterloo.

Contact: Pamela Smyth
University of Waterloo

Public Release: 4-May-2015
Nature Methods
Scientists dramatically improve method for finding common genetic alterations in tumors
St. Jude Children's Research Hospital scientists have developed a significantly better computer tool for finding genetic alterations that play an important role in many cancers but were difficult to identify with whole-genome sequencing. The findings appear today in the scientific journal Nature Methods.
Pediatric Cancer Genome Project, Kay Jewelers, NIH/National Cancer Institute, and ALSAC

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

Public Release: 1-May-2015
Cancer Epidemiology, Biomarkers & Prevention
Lifetime intense physical activity may lower risk for non-Hodgkin lymphoma
Performing vigorous physical activity over one's lifetime may lower risk for non-Hodgkin lymphoma.
Canadian Cancer Society, Canadian Institutes of Health Research

Contact: Lauren Riley
American Association for Cancer Research

Public Release: 1-May-2015
Cancer Epidemiology, Biomarkers & Prevention
Prolonged statin use may lower risk of lung cancer death
Lung cancer patients who used statins in the year prior to a lung cancer diagnosis or after a lung cancer diagnosis had a reduction in the risk of death from the disease.
Health and Social Care Research, Development Division of the Public Health Agency of Northern Ireland

Contact: Lauren Riley
American Association for Cancer Research

Public Release: 1-May-2015
Genes & Development
UNC researchers create DNA repair map of the entire human genome
When common chemotherapy drugs hit cancer cells, they damage DNA so that the cells can't replicate. But the cells have ways to repair the DNA, and the drugs aren't effective enough. UNC researchers created a way to find where this DNA repair happens throughout all of human DNA. The finding offers scientists a route to target the proteins cancer cells use to circumnavigate therapy. The benefit could be more effective and better cancer therapeutics.
National Institutes of Health

Contact: Mark Derewicz
University of North Carolina Health Care

Public Release: 1-May-2015
Patients with gastrointestinal tumors at higher risk of other cancers
Researchers at UC San Diego School of Medicine conducted the first population-based study that characterizes the association and temporal relationship between gastrointestinal stromal tumors (GIST) and other cancers. The results, published by Cancer on April 30, indicate that one in 5.8 patients with GIST will develop additional malignancies before and after their diagnosis.
National Institutes of Health, GIST Research Fund, UC San Diego Academic Senate Health Sciences Research Grant

Contact: Yadira Galindo
University of California - San Diego

Public Release: 1-May-2015
Proceedings of the National Academy of Sciences
How to reset a diseased cell
In proof-of-concept experiments, researchers at University of California, San Diego School of Medicine demonstrate the ability to tune medically relevant cell behaviors by manipulating a key hub in cell communication networks. The manipulation of this communication node, reported in this week's issue of Proceedings of the National Academy of Sciences, makes it possible to reprogram large parts of a cell's signaling network instead of targeting only a single receptor or cell signaling pathway.
National Institutes of Health, American Cancer Society, Burroughs Wellcome Fund, Dorris Duke Charitable Foundation, American Heart Association

Contact: Scott LaFee
University of California - San Diego

Public Release: 1-May-2015
TGen-UCSF study in Neuro-Oncology provides comprehensive look at brain cancer treatments
Led by TGen and UCSF, a comprehensive genetic review of treatment strategies for glioblastoma brain tumors was published today in the Oxford University Press journal Neuro-Oncology. The study, 'Towards Precision Medicine in Glioblastoma: The Promise and The Challenges,' covers how these highly invasive and almost-always-deadly brain cancers may be treated, reviews the continuing challenges faced by researchers and clinicians, and presents the hope for better treatments by harnessing the power of the human genome.
Ben & Catherine Ivy Foundation

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Public Release: 30-Apr-2015
New origin theory for cells that gave rise to vertebrates
Zebras' vivid pigmentation and the fight or flight instinct. These and other features of the world's vertebrates stem from neural crest cells, but little is known about their origin. Northwestern University scientists propose a new model for how neural crest cells, and thus vertebrates, arose more than 500 million years ago. They report that these cells retain the molecular underpinnings that control pluripotency -- the ability to give rise to all the cell types that make up the body.
National Institutes of Health

Contact: Megan Fellman
Northwestern University

Public Release: 30-Apr-2015
The International Liver Congress 2015
Study results promising for hepatitis C patients awaiting or completing liver transplant
Hepatitis C patients who are awaiting a liver transplant or have completed one are a difficult group to cure because hepatitis C can come back after transplant. The ALLY-1 trial, led by Fred Poordad, M.D., showed that a large number of these patients can be cured with an oral regimen of daclatasvir, sofosbuvir and ribavirin. Treatment was well tolerated with few serious side effects.
Bristol-Myers Squibb

Contact: Rosanne Fohn
University of Texas Health Science Center at San Antonio

Public Release: 30-Apr-2015
U of M institute discovers how aspirin fights cancer
Taking aspirin reduces a person's risk of colorectal cancer, but the molecular mechanisms involved have remained unknown until a recent discovery by The Hormel Institute, University of Minnesota.

Contact: Tim Ruzek
University of Minnesota

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