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Public Release: 31-Jul-2014
New England Journal of Medicine
Transplantation shown to be highly effective in treating immune deficiency in children
Babies who are born with severe combined immunodeficiency can be successfully treated with a transplant of blood-forming stem cells, according to experts led by Memorial Sloan Kettering's Richard J. O'Reilly, M.D.
NIH/National Institute of Allergy and Infectious Diseases, National Institutes of Health

Contact: Courtney DeNicola Nowak
denicolc@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center

Public Release: 30-Jul-2014
Nature
Target growth-driving cells within tumors, not fastest-proliferating cells
A Dana-Farber study shows growth-driving cancer cells may be better targets for therapies than cells that proliferate the fastest within the tumor.
Dana-Farber Cancer Institute Physical Sciences-Oncology Center, CDMRP Breast Cancer Research Program, Cellex Foundation, Deutsche Akademie der Naturforscher Leopoldina, Breast Cancer Research Foundation

Contact: Teresa M. Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute

Public Release: 30-Jul-2014
Cancer
Acupuncture improves quality of life for breast cancer patients using aromatase inhibitors
Use of electroacupuncture (EA) produces significant improvements in fatigue, anxiety and depression in as little as eight weeks for early stage breast cancer patients experiencing joint pain related to the use of aromatase inhibitors to treat breast cancer. The study is the first demonstration of EA's efficacy for both joint pain relief, as well as these other common symptoms.
National Institutes of Health

Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-349-5964
University of Pennsylvania School of Medicine

Public Release: 30-Jul-2014
Cell Reports
Biologists describe mechanism promoting multiple DNA mutations
The finding that cancer development often involves multiple mutations arising in clusters and in regions where chromosomal rearrangement takes place may one day lead to new cancer therapies.
National Institutes of Health

Contact: Gary Galluzzo
gary-galluzzo@uiowa.edu
319-384-0009
University of Iowa

Public Release: 30-Jul-2014
British Journal of Cancer
Scientists pinpoint bladder cancer patients who could benefit from 'tumor-softening' treatment
Scientists in Manchester have identified a protein that could help doctors decide which bladder cancer patients would benefit from a treatment that makes radiotherapy more effective.
Cancer Research UK

Contact: Flora Malein
flora.malein@cancer.org.uk
44-203-469-8300
Cancer Research UK

Public Release: 29-Jul-2014
Current Biology
Researchers uncover secrets of internal cell fine-tuning
New research from scientists at the University of Kent has shown for the first time how the structures inside cells are regulated -- a breakthrough that could have a major impact on cancer therapy development.

Contact: Martin Herrema
M.J.Herrema@kent.ac.uk
01-227-823-581
University of Kent

Public Release: 29-Jul-2014
International Journal of Radiation Oncology, Biology, Physics
Genomic analysis of prostate cancer indicates best course of action after surgery
The study in the postoperative radiation oncology field to show that molecular signature of patient's tumor can help stratify patients requiring additional treatment.

Contact: Edyta Zielinska
edyta.zielinska@jefferson.edu
215-955-5291
Thomas Jefferson University

Public Release: 29-Jul-2014
Proceedings of the National Academy of Sciences
Research may explain how foremost anticancer 'guardian' protein learned to switch sides
A cellular program that evolved over eons to heal wounds may have been hijacked by mutant p53 proteins to enable cancers to spread out of control.
Damon Runyon Cancer Research Foundation

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Public Release: 29-Jul-2014
Nucleic Acids Research
Brazilian researchers identify RNA that regulates cell death
Researchers from the University of Sao Paulo have identified an RNA known as INXS that modulates the action of an important gene in the process of programmed cell death. In experiments on mice, they were able to effect a 10-fold reduction in the volume of subcutaneous malignant tumors. The findings were published in the most recent issue of the journal Nucleic Acids Research.
Sao Paulo Research Foundation, Fundação de Amparo à Pesquisa do Estado de São Paulo

Contact: Samuel Antenor
samuel@fapesp.br
55-113-838-4381
Fundação de Amparo à Pesquisa do Estado de São Paulo

Public Release: 29-Jul-2014
PLOS ONE
Penn team makes cancer glow to improve surgical outcomes
The best way to cure most cases of cancer is to surgically remove the tumor. The Achilles heel of this approach, however, is that the surgeon may fail to extract the entire tumor, leading to a local recurrence. With a new technique, researchers at the University of Pennsylvania have established a new strategy to help surgeons see the entire tumor in the patient, increasing the likelihood of a positive outcome.
American Surgical Association, National Institutes of Health

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania

Public Release: 28-Jul-2014
Cancer & Metabolism
Cancer: Tumors absorb sugar for mobility
Researchers were able to demonstrate that appetite for sugar and 'mesenchymal behavior' result from the same mechanism. They also showed that the intensity of the phenomenon significantly influenced the chances of patient survival. Published in Cancer & Metabolism, this discovery opens up new potential targets for future therapies.

Contact: Lionel Pousaz
lionel.pousaz@epfl.ch
41-795-597-161
Ecole Polytechnique Fédérale de Lausanne

Public Release: 28-Jul-2014
FASEB Journal
Potential 'universal' blood test for cancer discovered
Researchers from the University of Bradford, UK, have devised a simple blood test that can be used to diagnose whether people have cancer or not.

Contact: Jenny Watkinson
j.watkinson2@bradford.ac.uk
44-127-423-6030
University of Bradford

Public Release: 28-Jul-2014
Proceedings of the National Academy of Sciences
Cell's recycling center implicated in division decisions
Most cells do not divide unless there is enough oxygen present to support their offspring, but certain cancer cells and other cell types circumvent this rule. Researchers at The Johns Hopkins University have now identified a mechanism that overrides the cells' warning signals, enabling cancers to continue to divide even without a robust blood supply. In the process, the researchers found that lysosomes -- the cell's protein 'recycling centers' -- help govern cell division decisions.
NIH/National Cancer Institute, American Cancer Society

Contact: Catherine Kolf
ckolf@jhmi.edu
443-440-1929
Johns Hopkins Medicine

Public Release: 28-Jul-2014
Cancer
Lifestyle choices may affect the long-term heart health of childhood cancer survivors
A new study has found that following a healthy lifestyle may lower childhood cancer survivors' risk of developing the metabolic syndrome.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
Wiley

Public Release: 28-Jul-2014
Toxicology in Vitro
Nicotine found to inhibit DNA-strand break caused by a certain carcinogen in smoke
A new in vitro study has revealed that nicotine and cotinine, a metabolite of nicotine, can potentially inhibit DNA damage caused by a certain carcinogen in smoke. The carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone or NNK is produced during the curing of tobacco leaves and ultimately ends up in the tobacco smoke.
British American Tobacco

Contact: Marina Murphy
marina_murphy@bat.com
44-077-111-50135
R&D at British American Tobacco

Public Release: 28-Jul-2014
Nature
Same cancer, different time zone
Just as no two people possess the same genetic makeup, a recent study has shown that no two single tumor cells in breast cancer patients have an identical genome. In fact, depending on the tumor cell, they grow at dramatically different speeds, according to a study led by Nicholas Navin, Ph.D., assistant professor in the Department of Genetics at the University of Texas M.D. Anderson Cancer Center in Houston.

Contact: Ron Gilmore
rlgilmore1@mdanderson.org
713-745-1898
University of Texas M. D. Anderson Cancer Center

Public Release: 28-Jul-2014
Lancet
New pill regimens published in The Lancet cure hardest-to-treat hepatitis C patients
Today, July 28, 2014, is World Hepatitis Day. Dr. Eric Lawitz, from the University of Texas Health Science Center at San Antonio and the Texas Liver Institute, led a national study that identified a simple, pill-only treatment for hepatitis C that can cure 93 percent of patients in 12 weeks. This replaces a long and complicated treatment with many serious side effects. The study results are published today in The Lancet.
Janssen

Contact: Rosanne Fohn
fohn@uthscsa.edu
210-567-3026
University of Texas Health Science Center at San Antonio

Public Release: 28-Jul-2014
Proceedings of the National Academy of Sciences
UTSW cancer researchers identify irreversible inhibitor for KRAS gene mutation
UT Southwestern Medical Center cancer researchers have found a molecule that selectively and irreversibly interferes with the activity of a mutated cancer gene common in 30 percent of tumors.
Cancer Research and Prevention Institute of Texas, The Welch Foundation

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 28-Jul-2014
Cell
Stem cell advance may increase efficiency of tissue regeneration
A new stem-cell discovery might one day lead to a more streamlined process for obtaining stem cells, which in turn could be used in the development of replacement tissue for failing body parts, according to UC San Francisco scientists.
California Institute for Regenerative Medicine, National Institutes of Health, UCSF Program for Breakthrough Biomedical Research, Netherlands Organization for Scientific Research, Sontag Foundation

Contact: Jeffrey Norris
jeffrey.norris@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 28-Jul-2014
Cancer
Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors
A St. Jude Children's Research Hospital study found that 73 percent of adult survivors of childhood cancer more than doubled their risk of developing metabolic syndrome and related health problems by failing to follow a heart-healthy lifestyle.
NIH/National Cancer Institute, ALSAC

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital

Public Release: 28-Jul-2014
Proceedings of the National Academy of Sciences
Scripps Florida scientists find genetic mutations linked to salivary gland tumors
Research conducted at the Florida campus of the Scripps Research Institute has discovered links between a set of genes known to promote tumor growth and mucoepidermoid carcinoma, an oral cancer that affects the salivary glands. The discovery could help physicians develop new treatments that target the cancer's underlying genetic causes.
NIH/National Cancer Institute, PGA National WCAD Cancer Research Fellowship, Ruth L. Kirschstein National Research Service Award, Margaret Q. Landerberger Research Foundation, Swiss National Foundation Postdoctoral Fellowship

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute

Public Release: 28-Jul-2014
Practical Radiation Oncology
Two-step decision tree analysis helps inform updates of RT best practices, quality standards
A two-step decision tree analysis, incorporating Donabedian's model, is a feasible process to evaluate and distill the many available quality standards, guidelines, recommendations and indicators in order to update national and international quality standards for radiation therapy, according to a study published in the July-August 2014 issue of Practical Radiation Oncology, the official clinical practice journal of the American Society for Radiation Oncology.

Contact: Michelle Kirkwood
press@astro.org
703-286-1600
American Society for Radiation Oncology

Public Release: 28-Jul-2014
Journal of the National Cancer Institute
Study helps compare risks of treatments for early esophageal cancer
A new study, published in the July 2014 issue of the Journal of the National Cancer Institute by Northwestern Medicine researchers, sheds new light on the risks associated with the growing popularity of endoscopic resection in the treatment of localized, early-stage esophageal cancer.
Northwestern University Robert H. Lurie Comprehensive Cancer Center's Northwestern Institute for Comparative Effectiveness Research in Oncology

Contact: Bret Coons
bcoons@nmh.org
312-926-2955
Northwestern Memorial Hospital

Public Release: 27-Jul-2014
Nature
New drug target can break down cancer's barrier against treatment
Scientists have found that a molecule -- focal adhesion kinase -- signals the body to repair itself after chemotherapy or radiotherapy, which kill cancer cells by damaging DNA.
Cancer Research UK

Contact: Greg Jones
greg.jones@cancer.org.uk
44-203-469-8311
Cancer Research UK

Public Release: 25-Jul-2014
International Journal of Cancer
Clearing cells to prevent cervical cancer
A study published online in the International Journal of Cancer earlier this month describes a novel approach to preventing cervical cancer based on findings showing successful reduction in the risk of cervical cancer after removal of a discrete population of cells in the cervix.

Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-534-6383
Brigham and Women's Hospital

Showing releases 1-25 out of 1281.

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