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Showing releases 1-25 out of 1281.

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Public Release: 27-Mar-2015
American Journal of Epidemiology
Study provides evidence against the fetal origins of cancer and cardiovascular disease
A study by researchers at Columbia's Mailman School of Public Health and in the Netherlands evaluated the relationship between nutritional conditions in early life and adult health, and found that famine exposure during the first pregnancy trimester was associated with increases in mortality from causes other than cancer or cardiovascular disease. This is the first study to quantify the possible long-term effects of nutrition deprivation at different stages of pregnancy and long-term mortality.
National Institutes of Health

Contact: Stephanie Berger
Columbia University's Mailman School of Public Health

Public Release: 27-Mar-2015
Nature Communications
MRI based on a sugar molecule can tell cancerous from noncancerous cells
Imaging tests like mammograms or CT scans can detect tumors, but figuring out whether a growth is or isn't cancer usually requires a biopsy to study cells directly. Now results of a Johns Hopkins study suggest that MRI could one day make biopsies more effective or even replace them altogether by noninvasively detecting telltale sugar molecules shed by the outer membranes of cancerous cells.
NIH/National Institute of Biomedical Imaging and Bioengineering, NIH/National Cancer Institute, Maryland Stem Cell Research Foundation, Pearl and Yueh-Heng Yang Foundation

Contact: Shawna Williams
Johns Hopkins Medicine

Public Release: 27-Mar-2015
Nature Communications
The switch that might tame the most aggressive of breast cancers
Australian researchers have found that so-called 'triple-negative breast cancers' are two distinct diseases that likely originate from different cell types. They have also found a gene that drives the aggressive disease, and hope to find a way to 'switch it off'.
Cancer Institute of NSW, National Health and Medical Research Council of Australia, National Breast Cancer Foundation Australia, Cancer Council NSW, The Sydney Breast Cancer Foundation

Contact: Alison Heather
Garvan Institute of Medical Research

Public Release: 27-Mar-2015
Nature Genetics
Integrative approaches key to understanding cancer, developing therapies, say Moffitt scientists
Moffitt Cancer Center researchers are using integrative approaches to study cancer by combining mathematical and computational modeling with experimental and clinical data. The use of integrative approaches enables scientists to study and model cancer progression in a manner that conventional experimental systems are unable to do.

Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 26-Mar-2015
Nature Communications
Blocking cellular quality control mechanism gives cancer chemotherapy a boost
Scientists have found a new way to make chemotherapy more effective against breast cancer cells. They show that blocking a cellular quality control mechanism before administering chemotherapy makes breast cancer cells die faster than when they were exposed to chemotherapy alone. The work is a long way from being applied in people, but it could lead to new treatment strategies for patients in the future.
NIH/National Institute for General Medical Sciences, University of Rochester Wilmot Cancer Institute, Damon Runyon Cancer Research Foundation

Contact: Emily Boynton
University of Rochester Medical Center

Public Release: 26-Mar-2015
JAMA Oncology
Fitness level associated with lower risk of some cancers, death in men
Men with a high fitness level in midlife appear to be at lower risk for lung and colorectal cancer, but not prostate cancer, and that higher fitness level also may put them at lower risk of death if they are diagnosed with cancer when they're older, according to a study published online by JAMA Oncology.

Contact: Sarah Keblin
The JAMA Network Journals

Public Release: 26-Mar-2015
Developmental Cell
Promising drug target identified in medulloblastoma
Scientists at Dana-Farber/Boston Children's Cancer and Blood Disorders Center have identified a protein critical to both the normal development of the brain and, in many cases, the development of medulloblastoma, a fast-growing brain tumor that usually strikes children under 10. As reported in Developmental Cell, when the researchers cut the level of the protein Eya1 in half in mice prone to develop medulloblastoma, the animals' risk of dying from the disease dropped dramatically.
National Institutes of Health, Pediatric Low-Grade Astrocytoma Foundation

Contact: Irene Sege
Dana-Farber Cancer Institute

Public Release: 26-Mar-2015
CA: A Cancer Journal for Clinicians
Prostate cancer and treatment choices -- a decision shared by doctor and patient?
Doctors strive to make treatment decisions together with their patients -- but is the decision really shared? According to adjunct professor Kari Tikkinen, shared decision-making isn't easy, and clinicians need help. The international research group led by Tikkinen has studied the decision aids for treatment choice of localized prostate cancer. The study was published in the CA: A Cancer Journal for Clinicians, which has the highest impact factor of any journal.

Contact: Kari Tikkinen
University of Helsinki

Public Release: 26-Mar-2015
Cell Metabolism
The CNIO develops an anti-obesity treatment in animal models
The study has been conducted on obese mice and monkeys, using a drug which inhibits the activity of the PI3K enzyme. The body weight loss was exclusively due to a reduction in fat mass and no toxic effects have been noted. The study also found an improvement in the symptoms of diabetes and hepatic steatosis (fatty liver disease). Obesity is one of the top risk factors within the spectrum of serious diseases that constitute metabolic syndrome.

Contact: Nuria Noriega
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 26-Mar-2015
Cell Reports
New role uncovered for 'oldest' tumor suppressor gene
Scientists have revealed a brand new function for one of the first cancer genes ever discovered -- the retinoblastoma gene -- in a finding that could open up exciting new approaches to treatment. The retinoblastoma gene is defective in many cancers and is known to play a central role in stopping healthy cells from dividing uncontrollably. This study has found that the gene also has another important function, in helping to 'glue' severed strands of DNA back together.
Cancer Research UK, Worldwide Cancer Research, Wellcome Trust, The Institute of Cancer Research, UCL

Contact: Claire Hastings
Institute of Cancer Research

Public Release: 26-Mar-2015
Moffitt Cancer Center research aims to reduce health care disparities
The lesbian, gay, bisexual, transgender/transsexual, queer/questioning and intersex (LGBTQI) population has been largely understudied by the medical community. Researchers at Moffitt Cancer Center found that the LGBTQI community experience health disparities due to reduced access to health care and health insurance, coupled with being at an elevated risk for multiple types of cancer when compared to non-LGBTQI populations.

Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 26-Mar-2015
Researcher overcomes radiation resistance in leukemia with an engineered precision medicine
A team of researchers led by Fatih M. Uckun, MD, PhD, of The Saban Research Institute of Children's Hospital Los Angeles and Professor at the University of Southern California Keck School of Medicine has determined that radiation resistance in leukemia can be overcome by using an engineered protein they recently designed and developed as a new precision medicine against leukemia.

Contact: Sacha Boucherie

Public Release: 26-Mar-2015
Newly updated treatment guidelines for medullary thyroid carcinoma
A Task Force convened by the American Thyroid Association released updated guidelines for the diagnosis and treatment of medullary thyroid carcinoma. The current document is the first revision of the original guidelines published in 2009. The Task Force has presented their recommendations in the article 'Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma,' in Thyroid, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

Contact: Vicki Cohn
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 26-Mar-2015
Experts set strategic priorities for lymphoma research
A committee of lymphoma experts today unveiled a strategic roadmap identifying key priority areas in both infrastructure and research that will be critical for advancing treatments for people with lymphoma.

Contact: Amanda Szabo
American Society of Hematology

Public Release: 26-Mar-2015
Clinical Gastroenterology and Hepatology
Female IBD patients: Stay up-to-date on your cervical cancer screening
Women with inflammatory bowel disease may be at increased risk of cervical dysplasia and cancer, according to a new study published in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association.

Contact: Rachel Steigerwald
American Gastroenterological Association

Public Release: 26-Mar-2015
2014 Western Surgical Association Annual Meeting
Journal of American College of Surgeons
Most women with early-stage breast cancer avoid extensive lymph node removal
A new study of women with early-stage breast cancer finds that surgeons no longer universally remove most of the lymph nodes in the underarm area when a biopsy of the nearby lymph nodes shows cancer -- a major change in breast cancer management.

Contact: Sally Garneski
American College of Surgeons

Public Release: 25-Mar-2015
Clinical Colorectal Cancer
Blood test can help some bowel cancer patients avoid unnecessary drug side-effects
Manchester researchers have provided early evidence to suggest that a blood test could be used to identify bowel cancer patients that may benefit from more intensive chemotherapy.

Contact: Jamie Brown
University of Manchester

Public Release: 25-Mar-2015
Promising drug a 'new paradigm' for treating leukemia
Researchers at the University of Virginia School of Medicine have developed a compound that delays leukemia in mice and effectively kills leukemia cells in human tissue samples, raising hopes that the drug could lead to improved treatments in people. The researchers call it an exciting 'new paradigm' for treating leukemia.
NIH/National Cancer Institute, Leukemia & Lymphoma Society

Contact: Josh Barney
University of Virginia Health System

Public Release: 25-Mar-2015
Journal of the National Cancer Institute
Marine ϖ-3 polyunsaturated fatty acid intake is associated with lower risk of MSI-high CRC
High intake of marine ϖ-3 polyunsaturated fatty acids is associated with lower risk of microsatellite instable (MSI) colorectal cancers (CRCs) but not microsatellite stable CRCs, according to a new study published March 25 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
Oxford University Press USA

Public Release: 25-Mar-2015
Nature Genetics
Like Angelina Jolie, study pinpoints genetic cause of increased leukemia risk
A University of Colorado Cancer Center study published today in the journal Nature Genetics describes a newly-discovered, heritable genetic cause of acute lymphoblastic leukemia, namely mutation of the gene ETV6.

Contact: Garth Sundem
University of Colorado Denver

Public Release: 25-Mar-2015
EMBO Reports
Control switch that modulates cell stress response may be key to multiple diseases
Researchers at the University of California, San Diego School of Medicine have discovered a control switch for the unfolded protein response, a cellular stress relief mechanism drawing major scientific interest because of its role in cancer, diabetes, inflammatory disorders and several neural degenerative disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
National Institutes of Health

Contact: Bonnie Ward
University of California - San Diego

Public Release: 25-Mar-2015
Nature Biotechnology
Researchers discover genetic origins of myelodysplastic syndrome using stem cells
Induced pluripotent stem cells (iPSCs) -- adult cells reprogrammed back to an embryonic stem cell-like state -- may better model the genetic contributions patient's particular disease.
National Institutes of Health, American Society of Hematology, Sidney Kimmel Foundation for Cancer Research, Aplastic Anemia & MDS International Foundation, Ellison Medical Foundation, Damon Runyon Cancer Research Foundation, and others

Contact: Lucia Lee
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 25-Mar-2015
Toxicology in Vitro
Researchers solve science behind scalp cooling and the reasons for hair loss in cancer treatment
HAIR loss is one of the most distressing side-effects of cancer treatment and can even deter some patients from undergoing life-saving chemotherapy. But researchers at the University of Huddersfield are establishing the scientific basis for a rapidly-advancing scalp cooling technology that can ensure hair retention in a vast number of cases.

Contact: Nicola Werritt
University of Huddersfield

Public Release: 25-Mar-2015
2015 Symposium on Global Cancer Research
Global Oncology launches Global Cancer Project Map for cancer research access with NCI
Nonprofit Global Oncology, Inc. today announced the launch of the Global Cancer Project Map, a first-of-its-kind online resource and virtual information exchange for connecting the global cancer community. Developed by GO in collaboration with the National Cancer Institute Center for Global Health, the Map enables worldwide access to cancer projects and expertise to improve cancer practices and patient outcomes, especially in low-resource settings.

Contact: Danna Remen
Global Oncology

Public Release: 24-Mar-2015
Genome Biology
Singapore identifies mutations that may enable earlier diagnosis of colorectal cancer recurrence
A multi-disciplinary team of doctors and scientists from Singapore has characterised the genetic changes associated with the spread of colorectal cancer to the liver.

Contact: Rachel Tan

Showing releases 1-25 out of 1281.

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