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Breaking News
Key: Meeting
Showing releases 1-25 out of 1124.
Public Release: 3-Dec-2012
Clinical trial hits new target in war on breast cancer Long known to drive prostate cancer, androgen receptors are a new target in breast cancer treatment. This week, a promising clinical trial at the University of Colorado Cancer Center flips from Phase I (proving safety) to Phase II (proving effectiveness). Contact: Garth Sundem
Public Release: 3-Dec-2012
 CancerCommon diabetes drug may help treat ovarian cancer A new study suggests that the common diabetes medication metformin may be considered for use in the prevention or treatment of ovarian cancer. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study found that ovarian cancer patients who took the drug tended to live longer than patients who did not take it. Contact: Amy Molnar
Public Release: 3-Dec-2012
Journal of Clinical InvestigationJCI early table of contents for Dec. 3, 2012 This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Monday, Dec. 3rd, 2012, in the JCI: Lithium restores cognitive function in Down syndrome mice; Stem cell-derived dopaminergic neruons rescue motor defects in Parkinsonian monkeys; Researchers inhibit plaque formation in a mouse model of Alzheimer's disease; Tempering inflammation to treat the flu; Lysosomal disruption targets acute myeloid leukemia cells; and many more. Contact: Jillian Hurst
Public Release: 3-Dec-2012
ACS NanoMultitasking plasmonic nanobubbles kill some cells, modify others Researchers at Rice University have found a way to kill some diseased cells and treat others in the same sample at the same time. The process activated by a pulse of laser light leaves neighboring healthy cells untouched. 
National Institutes of Health
Contact: David Ruth
Public Release: 3-Dec-2012
CancerMayo study: Common diabetes drug may treat ovarian cancer Diabetic patients with ovarian cancer who took the drug metformin for their diabetes had a better survival rate than patients who did not take it, a study headed by Mayo Clinic shows. The findings, published early online in the journal Cancer, may play an important role for researchers as they study the use of existing medications to treat different or new diseases. Contact: Kelley Luckstein
Public Release: 3-Dec-2012
Optics LettersWorld's smallest wrench puts a new twist on microscopic manipulation Harnessing laser light's ability to gently push and pull microscopic particles, researchers have created the fiber-optic equivalent of the world's smallest wrench. This virtual tool can precisely twist and turn the tiniest of particles, from living cells and DNA to microscopic motors and dynamos used in biological and physical research. The authors describe their new technique in a paper published today in the Optical Society's journal Optics Letters. Contact: Angela Stark
Public Release: 3-Dec-2012
Biochemical and Molecular ToxicologyU-M study shows BPA exposure in fetal livers New research from the University of Michigan School of Public Health found BPA, or bisphenol A, in fetal liver tissue, demonstrating that there is considerable exposure to the chemical during pregnancy. Contact: Laurel Thomas Gnagey
Public Release: 3-Dec-2012
Journal of Nuclear MedicinePET imaging used to more accurately manage treatment, predict survival for patients with gliomas In the management of gliomas -- tumors that originate in the brain -- precise assessment of tumor grade and the proliferative activity of cells plays a major role in determining the most appropriate treatment and predicting overall survival. Research published in the December issue of the Journal of Nuclear Medicine highlights the potential of imaging with 3'-deoxy-3'-F-18-fluorothymidine positron emission tomography to non-invasively and accurately provide tumor-specific details to guide management of patients with gliomas. Contact: Susan Martonik
Public Release: 3-Dec-2012
Deutsches Ärzteblatt InternationalCancer screening: The efficacy of mammography screening How effective is the German mammography screening program? This is the question examined by Oliver Heidinger of the Epidemiological Cancer Registry North Rhine–Westphalia and his co-authors in the first study on this subject in Germany, in Deutsches Arzteblatt International. Contact: Oliver Heidinger
Public Release: 3-Dec-2012
Journal of Clinical OncologyAmerican Society of Clinical Oncology issues annual report on state of clinical cancer science The American Society of Clinical Oncology (ASCO) has just released its annual report on the top cancer advances of the year. Clinical Cancer Advances 2012: ASCO's Annual Report on Progress Against Cancer, highlights major achievements in precision medicine, cancer screening and overcoming treatment resistance. Contact: Susie Tappouni
Public Release: 3-Dec-2012
Laryngoscope JournalExperts urge rapid evaluation for swallowing and voice problems after brain surgery Johns Hopkins experts are recommending early post-surgical assessment -- preferably within 24 hours -- for trouble chewing and swallowing food, or speaking normally, among patients who have had benign tumors removed from the base of the brain. Contact: David March
Public Release: 2-Dec-2012
Nature Structural & Molecular BiologyScientists at Scripps Research Institute discover how 2 proteins help keep cells healthy Scientists at The Scripps Research Institute have determined how two proteins help create organelles, or specialized subunits within a cell, that play a vital role in maintaining cell health. This discovery opens the door for research on substances that could interfere with the formation of these organelles and lead to new therapies for cancer.
National Institutes of Health, Japan Science and Technology Agency
Contact: Mika Ono
Public Release: 2-Dec-2012
Nature GeneticsNew gene-sequencing tools offer clues to highest-risk form of a childhood cancer Using powerful gene-analysis tools, researchers have discovered mutations in two related genes, ARID1A and ARID1B, that are involved in the most aggressive form of the childhood cancer neuroblastoma. While these findings do not immediately improve clinical treatments, they identify a novel pathway that is defective in these cancers, a pathway that scientists can now study to develop potential new therapies.
National Institutes of Health, St. Baldrick's Foundation, Children's Oncology Group, and others
Contact: Rachel Salis-Silverman
Public Release: 2-Dec-2012
Nature GeneticsCell surface transporters exploited for cancer drug delivery According to Whitehead Institute researchers, a protein known as monocarboxylate transporter 1 (MCT1), which is highly expressed in a subset of metabolically altered cancer cells, is needed for the entry of the investigational cancer drug 3-bromopyruvate (3-BrPA) into malignant cells. This work may open a new avenue for cancer therapeutic research, as other transport molecules have already been identified on the surface of certain cancer cells.
National Institutes of Health, David H. Koch Institute for Integrative Cancer Research, Jane Coffin Childs Fund, National Science Foundation
Contact: Nicole Rura
Public Release: 2-Dec-2012
Nature GeneticsScientists find 'bully' genes in common childhood tumor In a genome sequencing study of 74 neuroblastoma tumors in children, scientists at the Johns Hopkins Kimmel Cancer Center and the Children's Hospital of Philadelphia found that patients with changes in two genes, ARID1A and ARID1B, survive only a quarter as long as patients without the changes. The discovery could eventually lead to early identification of patients with aggressive neuroblastomas who may need additional treatments.
NIH/National Cancer Institute, St. Baldrick's Foundation
Contact: Vanessa Wasta
Public Release: 2-Dec-2012
SleepShifting the safety balance for overnight workers An international team of sleep researchers has developed the world's first screening tool to help reduce workplace accidents and illnesses, including cardiovascular disease and cancer, caused by shift work. Contact: Emily Walker
Public Release: 1-Dec-2012
Journal of Thoracic OncologyLung cancer patients with pockets of resistance prolong disease control by 'weeding the garden' This study of 65 patients showed that continuing either crizotinib or erlotinib after the treatment of resistant pockets with focused radiation ("weeding the garden") was associated with more than half a year of additional cancer control.
NIH/National Cancer Institute
Contact: Garth Sundem
Public Release: 1-Dec-2012
Genes & DevelopmentX-ray analysis deciphers master regulator important for skin cancer With the X-ray vision of DESY's light source DORIS, a research team from Hamburg and Iceland has uncovered the molecular structure of a master regulator central to the most deadly form of skin cancer, melanoma. The results, published in the scientific journal "Genes & Development", throw new light on the workings of the so-called Microphthalmia-associated Transcription Factor MITF, that is not only connected to skin cancer, but also to a variety of hereditary diseases. Contact: Thomas Zoufal
Public Release: 1-Dec-2012
Cancer ResearchResearchers identify a mechanism for the transformation of colon polyps The causes underlying the development of certain types of common cancers have not yet been elucidated. In order to better determine the origin and the sequence of events responsible for the onset of colon cancer, the teams led by Thanos Halazonetis and Stylianos Antonarakis, professors at the UNIGE, Switzerland, have sequenced the DNA of biopsied tissue from colon polyps. The results show that these precancerous lesions have a specific profile. Contact: Thanos Halazonetis
Public Release: 30-Nov-2012
American Society of Clinical OncologyIntermountain Healthcare Cancer research provides possible road map for improving healthcare Given the right equipment, training and skill, an individual surgeon can expect to provide the best possible care on a consistent basis. But how do you get an entire system of surgeons -- each with his or her own ideas, backgrounds, and routines -- to provide that same level of care? New Research by Intermountain Healthcare's Oncology Clinical Program shows that it's possible to improve care across the board if you tackle the problem in a standardized way, relying on the best evidence available. Contact: Jess C. Gomez
Public Release: 29-Nov-2012
StructureProteins that work at the ends of DNA could provide cancer insight New insights into a protein complex that regulates the very tips of chromosomes could improve methods of screening anti-cancer drugs. University of Illinois researchers determined the binding mechanism of proteins that protect and regulate telomeres, segments of repeating DNA units that cap the ends of chromosomes and a key target of cancer researchers.
American Cancer Society, Human Frontier Science Research Program
Contact: Liz Ahlberg
Public Release: 29-Nov-2012
Journal of Biological ChemistryActivating ALC1: With a little help from friends Chromatin remodeling -- the packaging and unpackaging of genomic DNA and its associated proteins -- regulates a host of fundamental cellular processes including gene transcription, DNA repair, programmed cell death as well as cell fate. In their latest study, scientists at the Stowers Institute for Medical Research are continuing to unravel the finicky details of how these architectural alterations are controlled.
NIH/National Institute of General Medical Sciences, Helen Nelson Medical Research Fund
Contact: Gina Kirchweger
Public Release: 29-Nov-2012
American Journal of PathologySt. Joseph's researchers identify gene involved in lung tumor growth Lung cancer researchers at St. Joseph's Hospital and Medical Center in Phoenix, Ariz., in collaboration with researchers at the Translational Genomics Research Institute and other institutions, have identified a gene that plays a role in the growth and spread of non-small cell lung cancer tumors, opening the door for potential new treatment options. Contact: Sara Baird
Public Release: 29-Nov-2012
Stress and Health Meditation with art therapy can change your brain and lower anxiety Cancer and stress go hand-in-hand, and high stress levels can lead to poorer health outcomes in cancer patients. The Jefferson-Myrna Brind Center of Integrative Medicine combined creative art therapy with a Mindfulness-based Stress Reduction program for women with breast cancer and showed changes in brain activity associated with lower stress and anxiety after the eight-week program. Their new study appears in the December issue of the journal Stress and Health. Contact: Lee-Ann Landis
Public Release: 29-Nov-2012
New England Journal of MedicineClinical trial delivers good results in leukemia patients Huntsman Cancer Institute researchers Michael Deininger, M.D., Ph.D., and Thomas O'Hare, Ph.D., were part of a team that found a potent oral drug, ponatinib, effective in patients who have developed resistance to standard treatments for chronic myeloid leukemia and Philadelphia chromosome positive acute lymphoblastic lymphoma. The New England Journal of Medicine released results of the trial today. Contact: Linda Aagard
Showing releases 1-25 out of 1124.
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