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Public Release: 30-Aug-2016
Nature Communications
Tasmanian devils evolve to resist deadly cancer
Tasmanian devils are evolving in response to a highly lethal and contagious form of cancer, a Washington State University researcher has found.
National Science Foundation, National Institutes of Health

Contact: Andrew Storfer
Washington State University

Public Release: 30-Aug-2016
Retinoic acid suppresses colorectal cancer development, Stanford study finds
Levels of retinoic acid, a vitamin A metabolite, are low in mice and humans with colorectal cancer, according to new research. People with high levels of an enzyme that degrades retinoic acid have a poor prognosis.

Contact: Ruthann Richter
Stanford University Medical Center

Public Release: 30-Aug-2016
Public Health Nursing
UofL research shows that children at home did not prompt parents to test for radon, secondhand smoke
Luz Huntington-Moskos, Ph.D., R.N., C.P.N., UofL School of Nursing assistant professor, recently published findings in the journal Public Health Nursing that show the presence of children in the home did not motivate parents to test and mitigate for radon and secondhand tobacco smoke, both of which cause lung cancer.
NIH/National Institute of Environmental Health Sciences

Contact: Hayley Kappes
University of Louisville

Public Release: 30-Aug-2016
American Journal of Transplantation
Inconsistent guidelines for screening transplant recipients at higher cancer risk: Study
People who have received organ transplants are at higher risk of developing and dying of cancer than the general population. Yet a new study has found cancer screening guidelines for this group are inconsistent as is the use of these guidelines.

Contact: Maria Feldman
St. Michael's Hospital

Public Release: 30-Aug-2016
A new animal model to understand metastasis in sarcomas
Researchers from IDIBELL have developed a modified version of an orthotopic model to recreate the metastatic steps in Ewing sarcoma, the second most common bone tumor in children and adolescents. This new model may become a valuable experimental tool to analyze metastatic potential in different kinds of sarcomas.

Contact: Gemma Fornons
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 30-Aug-2016
Genome Research
Variation in 'junk' DNA leads to trouble
Although genetic variants are scattered throughout the human genome, scientists have largely ignored the stretches of repetitive genetic code known as 'junk' DNA in their search for differences that influence human health and disease. Now, Duke researchers have discovered that variation in these overlooked regions can affect the stability of the genome and the proper function of the chromosomes that package our genetic material, leading to an increased risk of birth defects, infertility, and cancer.
March of Dimes, National Institutes of Health

Contact: Karl Bates
Duke University

Public Release: 30-Aug-2016
Mitosis study finds potential cancer target
By drilling down to the atomic level of how specific proteins interact during cell division, or mitosis, a team of scientists has found a unique new target for attacking cancer.
National Institutes of Health, Fund for Scientific Research, Biotechnology and Biological Science Research Council

Contact: David Orenstein
Brown University

Public Release: 30-Aug-2016
Nature Medicine
Cancer: Molecularly shutting down cancer cachexia
Healthy fat tissue is essential for extended survival in the event of tumor-induced wasting syndrome (cachexia). In Nature Medicine, researchers at Helmholtz Zentrum München show that selective manipulation of an enzyme can stop unwanted metabolic processes.

Contact: Sonja Opitz
Helmholtz Zentrum München - German Research Center for Environmental Health

Public Release: 30-Aug-2016
Science Signaling
How the 'police' of the cell world deal with 'intruders' and the 'injured'
Dr Anna Piccinini, an expert in inflammatory signalling pathways at The University of Nottingham, has discovered that the macrophage's 'destroy and repair service' is capable of discriminating between the two distinct threats even deploying a single sensor.
Medical Research Council, Arthritis Research UK, Kennedy Trust for Rheumatology Research

Contact: Lindsay Brooke
University of Nottingham

Public Release: 29-Aug-2016
Nature Genetics
Breast cancer researchers look beyond genes to find more drivers of disease development
Breast cancer researchers have discovered that mutations found outside of genes that accumulate in estrogen receptor positive breast tumors throughout their development act as dominant culprits driving the disease.
NIH/National Cancer Institute, Princess Margaret Cancer Foundation, Canadian Cancer Society, Susan G. Komen Foundation, Ontario Institute for Cancer Research, Canadian Institute of Health Research, and others

Contact: Jane Finlayson
University Health Network

Public Release: 29-Aug-2016
Proceedings of the National Academy of Sciences
Radiologists detect breast cancer in 'blink of an eye'
In a paper published Aug. 29 in PNAS, visual attention researchers showed radiologists mammograms for half a second and found that they could identify abnormal mammograms at better than chance levels. They further tested this ability through a series of experiments to explore what signal may alert radiologists to the presence of a possible abnormality, in the hopes of using these insights to improve breast cancer screening and early detection.
John S. Dunn, Sr., National Institutes of Health

Contact: Haley Bridger
Brigham and Women's Hospital

Public Release: 29-Aug-2016
Artificial intelligence expedites breast cancer risk prediction
Researchers have developed an artificial intelligence (AI) software that reliably interprets mammograms, assisting doctors with a quick and accurate prediction of breast cancer risk. The AI computer software intuitively translates patient charts into diagnostic information at 30 times human speed and with 99 percent accuracy.

Contact: Patricia Akinfenwa
Houston Methodist

Public Release: 29-Aug-2016
Annals of Internal Medicine
Sacubitril-valsartan cost-effective for treating reduced ejection fraction heart failure
Sacubitril-valsartan is reasonably cost effective compared to widely-used therapies for reducing mortality and morbidity in patients with reduced ejection fraction heart failure. The findings are published in Annals of Internal Medicine.

Contact: Angela Collom
American College of Physicians

Public Release: 29-Aug-2016
Proceedings of the National Academy of Sciences
Research outlines cellular communication processes that make life possible
Researchers have discovered a mechanism of intercellular communication that helps explain how biological systems and actions -- ranging from a beating heart to the ability to hit a home run -- function properly most of the time, and in some scenarios quite remarkably.
National Science Foundation

Contact: Bo Sun
Oregon State University

Public Release: 29-Aug-2016
Journal of Clinical Investigation
Study identifies potential targets for treating triple negative breast cancer
In this issue of the JCI, a team led by Eldad Zacksenhaus at Toronto General Research Institute discovered that the growth of TNBC-like breast tumors is supported by enhanced mitochondrial function.
US Army Department of Defense Breast Cancer Research, Canadian BC Foundation, Canadian Cancer Society, Terry Fox Foundation

Contact: Elyse Dankoski
JCI Journals

Public Release: 29-Aug-2016
Proceedings of the National Academy of Sciences
Vitamin C may boost effectiveness of acute myeloid leukemia treatment
A simple adjustment to patients' therapeutic regimen may improve the effectiveness of the standard epigenetic treatment for myeloid dysplastic syndrome (MDS) and acute myeloid leukemia (AML).

Contact: Beth Hinshaw Hall
Van Andel Research Institute

Public Release: 29-Aug-2016
Molecular switch may sensitize triple-negative breast cancers to immunotherapy
University of Colorado Cancer Center study offers compelling evidence that enzyme PRL-3 is 'switch' in TNF-R1 pathway, determining whether pathway helps cancer cells survive or die when challenged with immunotherapy.
National Institutes of Health

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 29-Aug-2016
Pediatric Blood and Cancer
Outpatient bloodstream infections costly for pediatric transplant and cancer patients
Pediatric stem cell transplant and cancer patients often are discharged from the hospital with an external central venous line for medications that parents or other caregivers must clean and flush daily to avoid potentially life-threatening infections. If an outpatient develops a bloodstream infection associated with the central line, median charges to treat it total $37,000 for a six-day hospital stay for young patients whose disease treatments have weakened their immune systems and infection-fighting abilities.

Contact: Irene Sege
Dana-Farber Cancer Institute

Public Release: 27-Aug-2016
ESC Congress 2016
European Heart Journal
ESC launches novel paper on tackling cardiac toxicity of anticancer therapies
The European Society of Cardiology has launched a novel position paper, under the auspices of its Committee for Practice Guidelines, on tackling the cardiac toxicity of anticancer therapies. The cardio-oncology paper is published online today in European Heart Journal and on the ESC website.

Contact: ESC Press Office
European Society of Cardiology

Public Release: 26-Aug-2016
Nature Communications
Discovery of a novel Wnt inhibitor with potential to eradicate colorectal cancer stem cells
A team of researchers has announced the development of a novel small-molecule Wnt inhibitor named NCB-0846. Wnt signaling is a key pathway of cancer stem cell development. The inhibitor may provide a new therapy option for patients with drug-refractory colorectal cancer.

Contact: Jens Wilkinson

Public Release: 26-Aug-2016
The Lancet Oncology
The first epigenetic test to diagnose tumors of unknown origin
An article published in The Lancet Oncology by Dr. Manel Esteller (IDIBELL) shows that it is possible to use a newly-developed epigenetic test called EPICUP® to find out what type of primary tumor is responsible for the metastasis in the patient in cancer of unknown primary cases, which will allow doctors to develop more specific treatments against it.

Contact: Gemma Fornons
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 26-Aug-2016
Science of the Total Environment
UTA study finds air contamination near fracking sites result of operational inefficiencies
Chemists at the University of Texas at Arlington have published a new study that indicates that highly variable contamination events registered in and around unconventional oil and gas developments are the result of operational inefficiencies and not inherent to the extraction process itself.
Shimadzu Institute for Research Technologies, The University of Texas at Arlington/Collaborative Laboratories for Environmental Analysis and Remediation

Contact: Louisa Kellie
University of Texas at Arlington

Public Release: 26-Aug-2016
Cell Stem Cell
Researchers find a new way to identify and target malignant aging in leukemia
Researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified RNA-based biomarkers that distinguish between normal, aging hematopoietic stem cells and leukemia stem cells associated with secondary acute myeloid leukemia (sAML), a particularly problematic disease that typically afflicts older patients who have often already experienced a bout with cancer.
The Leukemia & Lymphoma Society, Moores Foundation, Mizrahi Family Foundation, Sanford Stem Cell Clinical Center, National Institutes of Health, Federico Foundation, UC San Diego AML Research Fund, and others

Contact: Scott LaFee
University of California - San Diego

Public Release: 25-Aug-2016
ACS Nano
Designing ultrasound tools with Lego-like proteins
Protein engineering techniques might one day lead to colorful ultrasound images of cells deep within our bodies.

Contact: Whitney Clavin
California Institute of Technology

Public Release: 25-Aug-2016
Chemistry of Materials
Important advance made with new approach to 'control' cancer, not eliminate it
Researchers have created a new drug delivery system that could improve the effectiveness of an emerging concept in cancer treatment -- to dramatically slow and control tumors on a long-term, sustained basis, not necessarily aiming for their complete elimination.
Medical Research Foundation of Oregon

Contact: Adam Alani
Oregon State University

Showing releases 1-25 out of 1382.

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