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Showing releases 101-125 out of 1211.

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Public Release: 12-Jan-2015
Proceedings of the National Academy of Sciences
Researchers identify new gene mutations linked to colorectal cancer in African-Americans
Case Comprehensive Cancer Center researchers have identified new gene mutations unique to colon cancers in African Americans -- the population with the highest incidence and death rates of any group for this disease. This discovery -- namely, that colorectal cancers appear different on a molecular level in African-Americans -- offers new hope for these patients. With this groundbreaking knowledge, scientists now will seek to develop treatments to target the distinct nature of the disease in African-Americans.
NIH/National Cancer Institute

Contact: Jeannette Spalding
Case Western Reserve University

Public Release: 12-Jan-2015
Molecular Cancer Research
Potentially targetable signaling pathway generates slowly proliferating, chemo-resistant cancer cells
A signaling pathway responsible for the generation of slowly proliferating cancer cells, which are hard to eradicate with current treatments and thought to be a cause of subsequent disease relapse, has been reported in a Rapid Impact study published in Molecular Cancer Research, a journal of the American Association for Cancer Research.
Stand Up To Cancer, NIH/National Cancer Institute, Susan G. Komen, Instituto de Salud Carlos III, Prostate Cancer Foundation, Howard Hughes Medical Institute, National Council for Scientific and Technological Development in Brazil

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 12-Jan-2015
Many cancer survivors have unmet physical and mental needs related to their disease and its treatment
Even decades after being cured, many cancer survivors face physical and mental challenges resulting from their disease and its treatment.

Contact: Evelyn Martinez

Public Release: 12-Jan-2015
Lancet Oncology
FDA approved drug extends survival for patients with rare cancer
Sunitinib, an agent approved for use in several cancers, provides unprecedented antitumor activity in thymic carcinoma, a rare but aggressive tumor of the thymus gland, according to a phase II clinical trial.
National Institutes of Health, NIH/National Cancer Institute, Cancer Therapy Evaluation Program

Contact: Karen Teber
Georgetown University Medical Center

Public Release: 12-Jan-2015
'Survival' protein a target in drug-resistant non-Hodgkin lymphomas
Melbourne researchers have discovered that targeting a cell 'survival' protein could help treat some lymphomas, including those cancers with genetic defects that make them resistant to many existing therapies.
Australian National Health and Medical Research Council, Cancer Therapeutics Cooperative Research Centre, Cancer Council Victoria, The Lady Tata Memorial Trust, Leukemia & Lymphoma Society, Victorian Government

Contact: Alan Gill
Walter and Eliza Hall Institute

Public Release: 9-Jan-2015
Nature Communications
Novel breast cancer gene found
Overactivity of the BCL11A gene has been linked to a number of difficult-to-treat breast cancers: triple-negative breast cancer. This discovery will inform the search for new targeted treatments for these hard-to-treat tumors.
Wellcome Trust, Wellcome Trust Sanger Institute, Biotechnology and Biological Sciences Research Council, King's College -- Cambridge, Cancer Research UK, Hutchinson Whampoa Ltd., Medical Research Council

Contact: Mark Thomson
Wellcome Trust Sanger Institute

Public Release: 9-Jan-2015
Coupling head and neck cancer screening and lung cancer scans could improve survival
Adding head and neck cancer screenings to newly recommended lung cancer screenings would likely improve early detection and survival, according to a multidisciplinary team led by scientists affiliated with the University of Pittsburgh Cancer Institute.
National Institutes of Health

Contact: Allison Hydzik
University of Pittsburgh Schools of the Health Sciences

Public Release: 9-Jan-2015
Nature Communications
Bacteria could contribute to development of wound-induced skin cancer
Researchers at King's College London have identified a new mechanism by which skin damage triggers the formation of tumors, which could have important therapeutic implications for patients suffering with chronic ulcers or skin blistering diseases.
Medical Research Council, Wellcome Trust

Contact: Jack Stonebridge
King's College London

Public Release: 9-Jan-2015
Cell Reports
Tumor-blocking role found for cell regulation molecule
Manchester scientists have explored the role of a protein in regulating tumor development and found that it suppresses liver cancer growth in the lab.

Contact: Jamie Brown
University of Manchester

Public Release: 9-Jan-2015
Mayo researchers find cancer biopsies do not promote cancer spread
A study of more than 2,000 patients by researchers at Mayo Clinic's campus in Jacksonville, Fla., has dispelled the myth that cancer biopsies cause cancer to spread. In the Jan. 9 online issue of Gut, they show that patients who received a biopsy had a better outcome and longer survival than patients who did not have a biopsy.

Contact: Kevin Punsky
Mayo Clinic

Public Release: 9-Jan-2015
Agent Orange-contaminated airplanes could have affected health of air force reservists
Air Force reservists based in the US who worked after the Vietnam War in C-123 aircraft that sprayed Agent Orange during the war could have experienced adverse health effects from exposure to the herbicide, says a new report from the Institute of Medicine.

Contact: Jennifer Walsh
National Academy of Sciences

Public Release: 9-Jan-2015
International Journal of Radiation Oncology • Biology • Physics
Secondary analysis of RTOG 0247 demonstrates favorable OS rates for rectal cancer patients
Locally advanced rectal cancer patients who receive preoperative radiation therapy with either irinotecan plus capecitabine or oxaliplatin plus capecitabine have a four-year overall survival rate of 85 percent and 75 percent, respectively, according to a study published in the Jan. 1, 2015, issue of the International Journal of Radiation Oncology * Biology * Physics, the official scientific journal of the American Society for Radiation Oncology.

Contact: Michelle Kirkwood
American Society for Radiation Oncology

Public Release: 8-Jan-2015
New study findings help physicians and patients determine prostate cancer risk
A discovery by researchers at Huntsman Cancer Institute shows that looking at whether a man's uncles and great-grandparents, among other second- and third-degree relatives, had prostate cancer could be as important as looking at whether his father had prostate cancer. A more complete family history would give physicians a new tool to decide whether or not a prostate-specific antigen test was appropriate.
US Department of Defense, NIH/National Cancer Institute, Huntsman Cancer Foundation

Contact: Linda Aagard
University of Utah Health Sciences

Public Release: 8-Jan-2015
Scientists illuminate mysterious molecular mechanism powering cells in most forms of life
A team led by structural biologists at The Scripps Research Institute has taken a big step toward understanding the intricate molecular mechanism of a metabolic enzyme produced in most forms of life on Earth. The finding concerns nicotinamide nucleotide transhydrogenase, an ancient evolutionary enzyme that is part of a process key to maintaining healthy cells and has also recently been linked to diseases such as diabetes and cancer.
National Institutes of Health, NIH/National Institute of General Medical Sciences

Contact: Madeline McCurry-Schmidt
Scripps Research Institute

Public Release: 8-Jan-2015
Journal of the Academy of Nutrition and Dietetics
Nutrition intervention leads to dietary behavior changes in Latina breast cancer survivors
An intervention designed to provide Latina breast cancer survivors with the knowledge and skills needed to change and sustain dietary behaviors helps survivors adhere to recommended guidelines to eat a diet high in fruits and vegetables. Using a culturally based hands-on educational approach, the program is geared toward Latina breast cancer survivors whose are at higher risk of high obesity rates, low physical activity rates, and poorer access to quality healthcare.
NIH/National Cancer Institute

Contact: Stephanie Berger
Columbia University's Mailman School of Public Health

Public Release: 8-Jan-2015
Cancer Cell
Blood vessel lining cells control metastasis
Scientists from the German Cancer Research Center in Heidelberg and from the Medical Faculty Mannheim of Heidelberg University paved the way for an innovative combination therapy against metastases: They treated mice with a combination of a low-dose metronomic chemotherapy and an antibody against Ang-2, a regulatory protein of the blood vessel lining cells. The treated animals had significantly less metastases.

Contact: Dr. Sibylle Kohlstädt
German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)

Public Release: 8-Jan-2015
Pathology -- Research and Practice
In head and neck cancer, surgeons need solid answers about tumor recurrence
Partnering with head and neck surgeons, pathologists developed a new use for an old test to determine if a patient's cancer is recurring, or if the biopsy shows benign inflammation of mucosal tissues. Candice C. Black, D.O., explained how her team confirmed the utility of ProExC, an existing antibody cocktail commonly used for pathology tests of the uterine cervix.
The Prouty

Contact: Kirk Cassels
The Geisel School of Medicine at Dartmouth

Public Release: 8-Jan-2015
Gynecologic Oncology
Screening HPV infection alone more accurate than Pap test in detection of cervical cancer
Screening for human papillomavirus (HPV) infection alone gives more accurate results than Pap testing for cervical cancer, say the authors of two papers to published today in the journal Gynecologic Oncology.

Contact: Sarah Jenkins

Public Release: 8-Jan-2015
AMP releases 'A Molecular Diagnostic Perfect Storm' paper
Health care providers -- those developing and delivering innovative diagnostic tests -- along with patients, who are the ultimate intended beneficiaries, are caught in the middle of policies imposed by FDA and CMS.

Contact: Catherine Davidge
Association for Molecular Pathology

Public Release: 8-Jan-2015
Lancet Respiratory Medicine
How quickly smokers metabolize nicotine may point to most effective way to quit
In a first-of-its-kind randomized clinical trial, researchers from Penn Medicine and collaborators have shown that the most-suited treatment for each smoker may depend on how quickly they metabolize the nicotine in their body after quitting.
NIH/National Institute on Drug Abuse, NIH/National Cancer Institute, NIH/National Institute of General Medical Sciences, NIH/National Human Genome Research Institute

Contact: Steve Graff
University of Pennsylvania School of Medicine

Public Release: 7-Jan-2015
Sticking to lifestyle guidelines may reduce risk for certain cancers and for overall mortality
A study of nearly a half-million Americans has found that following cancer prevention guidelines from the American Cancer Society may modestly reduce your overall risk of developing cancer and have a greater impact on reducing your overall risk of dying. Having a healthy body weight and staying active appeared to have the most positive impact.

Contact: Deirdre Branley
Albert Einstein College of Medicine

Public Release: 7-Jan-2015
Tobacco Control
Study: Campus debit cards let students buy cigarettes with parents' money
A University of Colorado Cancer Center study published in the British Medical Journal: Tobacco Control shows that of the top 100 universities as ranked by US News and World Report, 11 allow tobacco sales and 13 allow e-cigarette sales on 'campus cash' debit cards that are commonly prepaid by parents.

Contact: Garth Sundem
University of Colorado Denver

Public Release: 7-Jan-2015
Science Translational Medicine
Surprise: High-dose testosterone therapy helps some men with advanced prostate cancer
In a surprising paradox, the male hormone testosterone, generally thought to be a feeder of prostate cancer, has been found to suppress some advanced prostate cancers and also may reverse resistance to testosterone-blocking drugs used to treat prostate cancer.
One-in-Six Foundation

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 7-Jan-2015
Practical Radiation Oncology
Physician survey indicates positive experience, desire for formal guidelines to improve peer review
A 2013 survey of radiation oncologists indicates that they would like more formal recommendations and guidance in order to improve the peer review process, according to a study published in the January-February 2015 issue of Practical Radiation Oncology, the clinical practice journal of the American Society for Radiation Oncology.

Contact: Michelle Kirkwood
American Society for Radiation Oncology

Public Release: 7-Jan-2015
Breast Cancer Research
Dartmouth develops prognostic test for E2F4 in breast cancer
By looking at the expression levels of downstream genes of the regulators in breast cancer, Dartmouth researchers have identified a gene signature in E2F4 that is predictive of estrogen receptor positive (ER+) breast cancer. The findings, published in Breast Cancer Research, define a new opportunity for personalizing medicine for women whose Oncotype DX assay results classify them as of 'intermediate-risk for recurrence.'
American Cancer Society Research, Centers of Biomedical Research Excellence, Geisel School of Medicine at Dartmouth College

Contact: Kirk Cassels
The Geisel School of Medicine at Dartmouth

Showing releases 101-125 out of 1211.

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