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Showing releases 101-125 out of 1216.

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Public Release: 17-Jul-2013
Molecular Therapy
Nano drug crosses blood-brain tumor barrier, targets brain-tumor cells and blood vessels
The blood-brain barrier protects the brain from poisons but also prevents drugs from reaching brain tumors. A preclinical study shows that an experimental nanotechnology drug called SapC-DOPS crosses the tumor blood-brain barrier, targets brain-tumor cells and retards growth of tumor blood vessels. The findings also show why the agent targets tumor cells and recommend the drug's further development as a novel treatment for glioblastoma.
NIH/National Cancer Institute, New Drug State Key Project

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center

Public Release: 17-Jul-2013
Journal of the National Cancer Institute
Epoetin alfa reduces anemia in breast cancer patients with no negative impact on survival
In patients with high-risk breast cancer, addition of the erythropoiesis-stimulating agent epoetin alfa to the chemotherapy regimen may help avoid the decrease in hemoglobin levels and resulting anemia often seen in these patients and does not negatively affect relapse-free or overall survival. However, it can increase the risk of thrombotic events, according to a study published July 17 in the Journal of the National Cancer Institute.

Contact: Zachary Rathner
Zachary.Rathner@oup.com
919-677-2697
Journal of the National Cancer Institute

Public Release: 17-Jul-2013
Nature
Molecular switch controls the destiny of self-eating cells
In a new paper published in the journal Nature, researchers present a previously unknown mechanism that controls whether a cell survives autophagy, a process that can be compared to the cell consuming parts of itself. The discovery means that it might now be possible to influence the process, which is involved in a wide variety of diseases.

Contact: Dr. Bertrand Joseph
bertrand.joseph@ki.se
46-073-073-0223
Karolinska Institutet

Public Release: 17-Jul-2013
Nature
Protein responsible for 'bad' blood vessel growth discovered
The discovery of a protein that encourages blood vessel growth, and especially "bad" blood vessels -- the kind that characterize diseases as diverse as cancer, age-related macular degeneration and rheumatoid arthritis -- has been reported in the journal Nature.
MRC, Lowy Medical Research Foundation, UCLB, Rosetrees Trust, NIHR Oxford Biomedical Research Centre-Moorfields, British Heart Foundation

Contact: Clare Ryan
clare.ryan@ucl.ac.uk
44-020-310-83846
University College London

Public Release: 17-Jul-2013
Menopause
Cancer survivors have more frequent and severe menopausal hot flashes
Women who survive cancer have more frequent, severe, and troubling hot flashes than other women with menopausal symptoms, according to a study published online today in Menopause, the journal of The North American Menopause Society. But surprisingly, the cancer survivors fare better psychologically and report a better quality of life than the women without cancer and have about the same levels of sexual activity and function.
King Edward Memorial Hospital, AstraZeneca, National Breast and Ovarian Cancer Centre, National Breast Cancer Foundation of Australia

Contact: Eileen Petridis
epetridis@fallscommunications.com
216-696-0229
The North American Menopause Society (NAMS)

Public Release: 17-Jul-2013
Science Translational Medicine
'Intelligent knife' tells surgeon which tissue is cancerous
Scientists have developed an "intelligent knife" that can tell surgeons immediately whether the tissue they are cutting is cancerous or not.
National Institute for Health Research Imperial Biomedical Research Centre, European Research Council, Hungarian National Office for Research and Technology

Contact: Sam Wong
sam.wong@imperial.ac.uk
44-207-594-2198
Imperial College London

Public Release: 17-Jul-2013
ACS Nano
Injectable 'smart sponge' holds promise for controlled drug delivery
Researchers have developed a drug delivery technique for diabetes treatment in which a sponge-like material surrounds an insulin core. The sponge expands and contracts in response to blood sugar levels to release insulin as needed. The technique could also be used for targeted drug delivery to cancer cells.
Leona M. and Harry B. Helmsley Charitable Trust Foundation, Tayebati Family Foundation

Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University

Public Release: 16-Jul-2013
Journal of Molecular Diagnostics
RNA diagnostic test from paraffin improves lung cancer diagnosis over routine microscopic evaluation
Scientists at the Universities of North Carolina and Utah have developed a histology expression predictor for the most common types of lung cancer: adenocarcinoma, carcinoid, small cell carcinoma and squamous cell carcinoma. This predictor can confirm histologic diagnosis in routinely collected paraffin samples of patients' tumors and can complement and corroborate pathologists' findings.
NIH/National Cancer Institute, Thomas G. Labreque Foundation, Joan's Legacy Foundation

Contact: Dianne Shaw
dgs@med.unc.edu
919-966-7834
University of North Carolina Health Care

Public Release: 16-Jul-2013
Cancer Investigation
Prostate cancers are fewer, smaller on walnut-enriched diet
New research from the School of Medicine at The University of Texas Health Science Center San Antonio indicates that eating a modest amount of walnuts can protect against prostate cancer. The study is described in the journal Cancer Investigation.
American Institute for Cancer Research

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio

Public Release: 16-Jul-2013
JAMA
Use of ADT for treatment of prostate cancer linked with increased risk of kidney injury
In a study that included more than 10,000 men with nonmetastatic prostate cancer, use of androgen deprivation therapy (ADT) was associated with a significantly increased risk of acute kidney injury, with variations observed with certain types of ADTs, according to a study in the July 17 issue of JAMA.

Contact: Tod Hoffman
thoffman@jgh.mcgill.ca
514-340-8222
The JAMA Network Journals

Public Release: 16-Jul-2013
European Heart Journal Cardiovascular Imaging
Chest radiation cancer patients with risk factors should have CV screening every 5-10 years
Cancer patients who receive chest radiation should be screened for heart disease every 5-10 years, according to the European Association of Cardiovascular Imaging of the European Society of Cardiology and the American Society of Echocardiography.

Contact: Jacqueline Partarrieu
press@escardio.org
33-492-947-756
European Society of Cardiology

Public Release: 16-Jul-2013
Laboratory Investigation
Tide is turning in skin cancer battle
Recent advances have put melanoma at the forefront of cancer research, raising hopes that scientists and clinicians may have cornered the deadliest of all skin cancers.

Contact: Jason Cody
jason.cody@cabs.msu.edu
517-432-0924
Michigan State University

Public Release: 16-Jul-2013
STI & AIDS World Congress
Study suggests STD clinics could reduce obstacles to much needed cervical cancer screenings
A new study found that STD clinics could provide important access to cervical cancer screenings for women who traditionally have trouble receiving these screenings because of lack of insurance or other obstacles. Cervical cancer can be painful and deadly but can be effectively treated if caught soon enough. Yet in the US, reaching women who are underscreened for this cancer remains a public health challenge because insurance is the primary indicator for screening.
Indiana Clinical and Translational Sciences Institute

Contact: Beth Meyerson
bmeyerson@indiana.edu
812-855-0585
Indiana University

Public Release: 16-Jul-2013
Molecular Biology of the Cell
Self-perpetuating signals may drive tumor cells to spread
A team of international researchers has identified a self-perpetuating signaling circuit inside connective tissue cells that allows these cells to form a front and a back and propel themselves in a particular direction over a long period of time. This propulsion is the same movement that tumor cells use to invade healthy tissue during cancer metastasis so cracking the code to this signaling network may lead to new therapeutic strategies.
Singapore Ministry of Education

Contact: Catherine Kolf
ckolf@jhmi.edu
410-287-2251
Johns Hopkins Medicine

Public Release: 16-Jul-2013
Immunity
Discovery of a new class of white blood cells uncovers target for better vaccine design
Scientists at A*STAR's Singapore Immunology Network have discovered a new class of white blood cells in human lung and gut tissues that play a critical role as the first line of defence against harmful fungal and bacterial infections. This research will have significant impact on the design of vaccines and targeted immunotherapies for diseases caused by infectious microbes such as the hospital-acquired pneumonia.
Agency for Science, Technology and Research

Contact: Dr. Sarah Chang
chang_kai_chen@a-star.edu.sg
65-682-66442
Agency for Science, Technology and Research (A*STAR), Singapore

Public Release: 16-Jul-2013
Cancer Research
UCLA researchers find link between intestinal bacteria and white blood cell cancer
This is the first demonstration that the intestinal microbiota plays a major role in longevity, genotoxicity, genetic instability, inflammation and latency of lymphoma in cancer predisposed mice.

Contact: Shaun Mason
smason@mednet.ucla.edu
310-206-2805
University of California - Los Angeles

Public Release: 16-Jul-2013
Nature Cell Biology
Molecular relative of p53 tumor suppressor protein also helps cancer cells thrive
The protein TAp73 is a relative of the well-known, tumor-suppressor protein p53, yet it is still not known whether TAp73 enhances tumor cell growth and, if so, exactly how. Penn researchers found that TAp73 supports the proliferation of human and mouse tumor cells. They also identify an important mechanism by which TAp73 gives tumor cells a growth advantage: it activates the expression of an enzyme important for cell replications and antioxidant protection.
NIH/National Cancer Institute, US Department of Defense

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 15-Jul-2013
Journal of Physics D: Applied Physics
York physicists offer novel insight into experimental cancer treatment
Physicists from the University of York have carried out new research into how the heating effect of an experimental cancer treatment works.

Contact: Caron Lett
caron.lett@york.ac.uk
44-019-043-22029
University of York

Public Release: 15-Jul-2013
European Journal of Cancer Prevention
Study reveals new dietary risk factors for colorectal cancer
Fizzy drinks, cakes, biscuits, crisps and desserts have all been identified as risk factors for bowel cancer, according to new research.
Medical Research Centre, Chief Scientist Office

Contact: Eleanor Cowie
Eleanor.Cowie@ed.ac.uk
44-131-650-6382
University of Edinburgh

Public Release: 15-Jul-2013
Nature
Biochemists uphold law of physics
Experiments by biochemists at UC Davis show for the first time that a law of physics, the ergodic theorem, can be demonstrated by a collection of individual protein molecules -- specifically, a protein that unwinds DNA.
National Institutes of Health

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis

Public Release: 15-Jul-2013
Journal of Experimental Medicine
Cancer researchers discover how BRCA1 mutation starts breast, ovarian cancers
Scientists led by Drs. Mona Gauthier and Tak Mak at The Campbell Family Institute for Breast Cancer Research at the Princess Margaret Cancer Centre have solved a key piece in the puzzle of how BRCA1 gene mutations specifically predispose women to breast and ovarian cancers.

Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network

Public Release: 15-Jul-2013
Molecular and Cellular Biology
Notre Dame researchers offer new insights on cancer cell signaling
A pair of studies by a team of University of Notre Dame researchers led by Crislyn D'Souza-Schorey, professor of biological sciences, sheds light on a biological process which is activated across a vast range of malignancies.

Contact: Crislyn D'Souza-Schorey
cdsouzas@nd.edu
574-631-3735
University of Notre Dame

Public Release: 15-Jul-2013
eLife
Protecting the body in good times and bad
The nasty side effects of radiation and chemotherapy are well known: Fatigue, hair loss and nausea, to name a few. Cancer treatment can seem as harsh as the disease because it can't differentiate healthy cells from cancerous cells, killing both.

Contact: Leah Burrows
lburrows@brandeis.edu
781-736-4027
Brandeis University

Public Release: 15-Jul-2013
Hormones & Cancer
Common autism supplement affects endocrine system
Plant-based diets are healthy. Plants are high in flavonoids. So flavonoids are healthy. At least that's the reasoning of many manufacturers of flavonoid-based nutritional supplements. But a University of Colorado Cancer Center study published this week in the journal Hormones & Cancer shows that may not be the case. Flavonoids tested in the study affected the endocrine system in ways that in one case promoted cancer and in another repressed it.

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

Public Release: 15-Jul-2013
PLOS ONE
CSI-style DNA fingerprinting tracks down cause of cancer spread
How do stationary cancer cells get the mutations that allow them to travel through the body to seed metastasis? Do they just grow these mutations themselves? Study shows that cancer cells fuse with blood cells -- which already can travel! -- to create a hybrid, metastatic cancer cell.

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

Showing releases 101-125 out of 1216.

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