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Showing releases 101-125 out of 1422.

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Public Release: 18-Jul-2016
Nature Chemical Biology
Scientists determine structure of enzyme linked with key cell-signaling protein
Scientists have captured atomic level snapshots showing how one key enzyme modifies a protein involved in turning genes on or off inside cells. Understanding this process helps explain how complex organisms can arise from a finite number of genes. The research also identifies links between defects in this particular enzyme and certain cancers, potentially pointing to new drug targets.
National Institutes of Health, Stony Brook University-Brookhaven National Laboratory Seed Grant, DOE/Office of Science, and Eli Lilly Company

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory

Public Release: 18-Jul-2016
Annals of Internal Medicine
High-fat Mediterranean diet may protect against breast cancer, diabetes and CVE
According to researchers, a healthy diet can include 'a lot of fat.' A review of available evidence suggests that a Mediterranean diet with no restrictions on fat intake may reduce a person's risk for breast cancer diabetes, and cardiovascular events compared to other diets. The findings are published in Annals of Internal Medicine.

Contact: Cara Graeff
cgraeff@acponline.org
215-351-2513
American College of Physicians

Public Release: 18-Jul-2016
PLOS Genetics
Size matters: Advance could increase sensitivity of liquid biopsies
A University of Utah School of Medicine-led study reports an advance that could increase the accuracy of liquid biopsies. The blood test monitors cancer progression by detecting pieces of circulating tumor DNA, but results can be obscured by abundant DNA from healthy cells. The research published in PLOS Genetics shows that the two types of DNA fragments are typically differently sized in cancer patients, a property that can be exploited to enhance the test's sensitivity.
NIH/National Cancer Institute

Contact: Julie Kiefer
julie.kiefer@hsc.utah.edu
801-597-4258
University of Utah Health Sciences

Public Release: 15-Jul-2016
Nature Protocols
New protocol enables analysis of metabolic products from fixed tissues
Scientists at the Helmholtz Zentrum München have developed a new mass spectrometry imaging method which, for the first time, makes it possible to analyze hundreds of metabolites in fixed tissue samples. Their findings, published in the journal Nature Protocols, explain the new access to metabolic information, which will offer previously unexploited potential for tissue-based research and molecular diagnostics.

Contact: Dr. Axel Karl Walch
axel.walch@helmholtz-muenchen.de
49-893-187-2739
Helmholtz Zentrum München - German Research Center for Environmental Health

Public Release: 15-Jul-2016
Cancer
Adjuvant chemotherapy in early-stage colon cancer may improve survival
Researchers and physicians have grappled with the role of 'adjuvant,' or post-surgery, chemotherapy for patients with early-stage colon cancer, even for cancers considered high risk. Now researchers from the University of Illinois at Chicago have found an association between the use of adjuvant chemotherapy in stage 2 colon cancer and improved survival -- regardless of a patient's age or risk, or even of the specific chemotherapy administered. The findings are published in the journal Cancer.
NIH/National Cancer Institute, National Institutes of Health

Contact: Jackie Carey
jmcarey@uic.edu
312-996-8277
University of Illinois at Chicago

Public Release: 15-Jul-2016
Nature Immunology
Proteins team up to turn on T cells
Scientists are learning how cells make the decision to become T cells.
CRI/Irvington Postdoctoral Fellowship, National Institutes of Health, California Institute for Regenerative Medicine, Al Sherman Foundation, Louis A. Garfinkle Memorial Laboratory Fund

Contact: Whitney Clavin
wclavin@caltech.edu
626-395-1856
California Institute of Technology

Public Release: 15-Jul-2016
Nature
New images of a calcium-shuttling molecule that has been linked to aggressive cancer
Scientists have captured new images of a calcium-shuttling molecule that has been linked to aggressive cancers. The three-dimensional structure could help researchers develop novel therapies and diagnostic tools for diseases that are caused by a malfunction in calcium adsorption.

Contact: Lucky Tran
lucky.tran@columbia.edu
212-305-3689
Columbia University Medical Center

Public Release: 14-Jul-2016
JAMA Oncology
What are your chances of living 2 years? Doctors, cancer patients, differ
Misunderstandings about prognosis between patients with advanced cancer and their doctors was common, in a study reported in JAMA Oncology, and the vast majority of patients didn't know that their doctors held different opinions about how long they might live.
National Institutes of Health

Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center

Public Release: 14-Jul-2016
Cell Reports
Scientists trace origin cell of bone and soft tissue tumors, test drug target
Scientists at Duke Health are part of a team that has discovered a type of cell surrounding blood vessels can also serve as a starting point for sarcoma, a form of cancer that occurs in bones and connective tissues.
National Institutes of Health

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

Public Release: 14-Jul-2016
Public Health Research & Practice
Forty years of the Nurses' Health Study: An evidence goldmine with a long-lasting legacy
A special journal issue on cohort studies highlights the Nurses' Health Study's major contribution.

Contact: Kellie Bisset
Kellie.Bisset@saxinstitute.org.au
01-161-434-614-578
Sax Institute

Public Release: 14-Jul-2016
Cell Stem Cell
Stem cell scientists discover genetic switch to increase supply of stem cells from cord blood
International stem cell scientists, co-led in Canada by Dr. John Dick and in the Netherlands by Dr. Gerald de Haan, have discovered the switch to harness the power of cord blood and potentially increase the supply of stem cells for cancer patients needing transplantation therapy to fight their disease.
Canadian Institutes of Health Research, Canadian Cancer Society Research Institute, Terry Fox Foundation, Ontario Institute for Cancer Research, Canada Research Chair in Stem Cell Biology, Princess Margaret Cancer Foundation, and others

Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network

Public Release: 14-Jul-2016
Cancer Research
Weight loss can lower levels of some proteins associated with cancer
Overweight and obese women who lost weight through diet and exercise lowered the levels of certain proteins in their blood that play a role in angiogenesis, the process of blood vessel growth that can promote the growth and survival of cancer cells.
NIH/National Cancer Institute, Breast Cancer Research Foundation

Contact: Lauren Riley
lauren.riley@aacr.org
215-446-7155
American Association for Cancer Research

Public Release: 14-Jul-2016
JAMA Oncology
Communication breakdown? Mismatch in expectations about prognosis in advanced cancer
A new study in JAMA Oncology finds that advanced cancer patients report far more optimistic expectations for survival prognosis than their oncologists, due to patients' misunderstanding of their oncologists' clinical judgment.
NIH/National Cancer Institute

Contact: Jennifer Nachbur
jennifer.nachbur@uvm.edu
802-338-8316
University of Vermont

Public Release: 14-Jul-2016
Science Immunology
Mount Sinai researchers develop simple method to characterize immune cells in tumors
Despite recent achievements in the development of cancer immunotherapies, only a small group of patients typically respond to them. Predictive markers of disease course and response to immunotherapy are urgently needed.

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 14-Jul-2016
Cell Chemical Biology
Anticancer drug discovery: Structures of KDM5 histone demethylase inhibitors
When doctors hurl toxic death at cancer cells, often a few will survive and come back. A family of enzymes called KDM5 histone demethylases is emerging as important for this resilience, and drugs that inhibit KDM5 enzymes could be active in treating several types of cancer.
NIH/National Cancer Institute, NIH/National Institute of General Medical Sciences, American Cancer Society, US Department of Defense, National Science Foundation, Arthur and Sarah Merrill Foundation, Winship Cancer Institute

Contact: Quinn Eastman
qeastma@emory.edu
404-727-7829
Emory Health Sciences

Public Release: 14-Jul-2016
Cancer Research
Losing weight lowered levels of proteins associated with tumor growth
Overweight or obese women who lost weight through diet or a combination of diet and exercise also significantly lowered levels of proteins in the blood that help certain tumors grow, according to a Fred Hutchinson Cancer Research Center study published July 14 in Cancer Research, a journal of the American Association for Cancer Research.
NIH/National Cancer Institute and Breast Cancer Research Foundation

Contact: Sandy Van
svan2@fredhutch.org
808-526-1708
Fred Hutchinson Cancer Research Center

Public Release: 14-Jul-2016
Aging
Moderately reducing calories in non-obese people reduces inflammation
Eating less may help us lead longer, healthier lives, according to new results from a large, multicenter study led by Tufts researchers. The paper reveals that a 25 percent reduction in calories can significantly lower markers of chronic inflammation without negatively impacting other parts of the immune system.
NIH/National Institute of Aging, US Department of Agriculture

Contact: Siobhan Gallagher
siobhan.gallagher@tufts.edu
617-230-2187
Tufts University, Health Sciences Campus

Public Release: 14-Jul-2016
Cancer Cell
Hybrid immune cells in early-stage lung cancer spur anti-tumor T cells to action
Researchers have identified a unique subset of these cells that exhibit hybrid characteristics of two immune cell types -- neutrophils and antigen-presenting cells -- in samples from early-stage human lung cancers. This is the first study to describe this phenomenon in a human tumor.
US Department of Defense, NIH/National Cancer Institute, Lung Cancer Translation Center of Excellence of the Abramson Cancer Center at Penn

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 14-Jul-2016
Science
Key to regulating cell's powerhouse discovered
Aging, neurodegenerative disorders and metabolic disease are all linked to mitochondria, structures within our cells that generate chemical energy and maintain their own DNA. In a fundamental discovery with far-reaching implications, scientists at UC Davis now show how cells control DNA synthesis in mitochondria and couple it to mitochondrial division.
NIH/National Institute of General Medical Sciences

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis

Public Release: 14-Jul-2016
Proceedings of the National Academy of Sciences
NUS scientists discover that modifications to protein RUNX3 may promote cancer growth
Scientists from the Cancer Science Institute of Singapore at the National University of Singapore have discovered that a modification called phosphorylation made to a protein called RUNX3 may promote cancer progression by allowing cell division. The phosphorylation, or the addition of a phosphate group to a molecule, is carried out by an enzyme called Aurora Kinase, which has been observed to be present in unusually high levels in some cancers.

Contact: Goh Yu Chong
yuchong.goh@nus.edu.sg
65-660-11653
National University of Singapore

Public Release: 14-Jul-2016
Angewandte Chemie International Edition
'Smart' nanoparticle called PEARLs a promising gem to target, treat tumours
Dr. Gang Zheng and a team of biomedical researchers have discovered a 'smart' organic, biodegradable nanoparticle that uses heat and light in a controlled manner to potentially target and ablate tumors with greater precision.
Terry Fox Research Institute, Prostate Cancer Canada, Canadian Institutes of Health Research, Ontario Institute for Cancer Research, Natural Sciences and Engineering Research Council of Canada, Canada Foundation for Innovation

Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network

Public Release: 14-Jul-2016
Journal of Immunology
OVC cancer breakthrough leads to human clinical trials
Cancer treatment in people could be transformed thanks to a study on treating cancer in animals at the University of Guelph. Injecting oncolytic viruses (viruses that target cancer cells) intravenously into the spleen allows immune responses to be boosted much more rapidly and to much higher magnitudes than traditional vaccine methods.

Contact: Byram Bridle
bbridle@uoguelph.ca
University of Guelph

Public Release: 14-Jul-2016
Bioorganic and Medicinal Chemistry Letters
New molecules kill multidrug-resistant cancer cells
Newly discovered molecules can kill multidrug-resistant cancer cells by blocking cells' defenses against cancer drugs, according to a new study published in Bioorganic & Medicinal Chemistry Letters. The lead author of the research, from the University of Navarra in Spain and Jagiellonian University Medical College in Poland, hopes the findings provide an initial step towards more effective treatments in the future against resistant cancers.

Contact: Annis Moreira
a.moreira@elsevier.com
31-204-852-770
Elsevier

Public Release: 14-Jul-2016
Cancer Cell
New signaling pathway for programmed cell death identified in leukemia cells
When adults develop blood cancer, they are frequently diagnosed with what is referred to as acute myeloid leukemia. The disease is triggered by pathological alterations of bone marrow cells, in which, in addition, an important mechanism is out of action: these cells do not die when they are damaged. Researchers from the Technical University of Munich (TUM) have now discovered a molecular signaling pathway for self-destruction that is suppressed in leukemia cells.

Contact: Paul Hellmich
paul.hellmich@tum.de
49-892-892-2731
Technical University of Munich (TUM)

Public Release: 14-Jul-2016
Science Signaling
Researchers map molecular 'social networks' that drive breast cancer cells
A powerful new technology that maps the 'social network' of proteins in breast cancer cells is providing detailed understanding of the disease at a molecular level and could eventually lead to new treatments, Australian scientists say.
Cancer Institute NSW, National Health and Medical Research Council, Science Foundation Ireland, NSW Office of Science and Medical Research, Guest Family Fellowship, Mostyn Family Foundation

Contact: Steve Offner
s.offner@unsw.edu.au
61-424-580-208
University of New South Wales

Showing releases 101-125 out of 1422.

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