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Showing releases 101-125 out of 1261.

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Public Release: 16-Mar-2015
Proceedings of the National Academy of Sciences
Stanford scientists change human leukemia cells into harmless immune cells
Researchers at the Stanford University School of Medicine have discovered a method that can cause dangerous leukemia cells to mature into harmless immune cells known as macrophages.
New York Stem Cell Foundation, The Burroughs Wellcome Fund, US Department of Defense, Walter V. and Idun Berry Postdoctoral Fellowship Program, National Institutes of Health

Contact: Christopher Vaughan
vaughan1@stanford.edu
650-736-8849
Stanford University Medical Center

Public Release: 16-Mar-2015
Breast Cancer Research
Dietary dioxins not associated with increased breast cancer risk
Estimated exposure to dioxins through dietary intake is not associated with an increased risk of developing a breast cancer among low exposed women, according to a large cohort study published in open access journal Breast Cancer Research. This contradicts a popular belief held by many about the effect of dioxins.

Contact: Shane Canning
shane.canning@biomedcentral.com
44-203-192-2243
BioMed Central

Public Release: 16-Mar-2015
Journal of Cell Biology
How NORE1A acts as a barrier to tumor growth
Researchers reveal how cells protect themselves from a protein that is a key driver of cancer.
National Institutes of Health

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

Public Release: 16-Mar-2015
Journal of the National Cancer Institute
Exercise affects tumor growth and drug response in a mouse model of breast cancer
Abnormal growth of blood vessels in solid tumors creates areas of hypoxia, which, in turn makes the tumors more aggressive and resistant to therapy. Exercise has been shown to improve blood vessel growth and perfusion of normal tissues and may have the same effect in solid tumors, according to a study published March 16 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
zachary.rathner@oup.com
919-677-2697
Oxford University Press USA

Public Release: 16-Mar-2015
EMBO Journal
MDC cancer researchers identify new function in an old acquaintance
Cells have two different programs to safeguard them from developing cancer. One of them is senescence. It puts cancer cells into a permanent sleep. Now researchers of the Max Delbrück Center have discovered that an enzyme known to be active in breast cancer blocks this protection program and boosts tumor growth. They succeeded in blocking this enzyme in mice with breast cancer, thus reactivating senescence and stopping tumor growth.
German Cancer Society/Deutsche Krebshillfe

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Max Delbrueck Center for Molecular Medicine (MDC) Berlin-Buch

Public Release: 16-Mar-2015
Angewandte Chemie
Rare African bush may help kidney cancer treatment
New research has shown why a bush that is only found in some African countries could hold a key to killing renal (kidney) cancer cells.

Contact: Chris Bunting
c.j.bunting@leeds.ac.uk
44-011-334-32049
University of Leeds

Public Release: 16-Mar-2015
Mayo Clinic Proceedings
Oncologists reveal reasons for high cost of cancer drugs in the US, recommend solutions
Increasingly high prices for cancer drugs are affecting patient care in the US and the American health care system overall, say the authors of a special article published online in the journal Mayo Clinic Proceedings.

Contact: Joe Dangor
newsbureau@mayo.edu
507-284-5005
Mayo Clinic

Public Release: 16-Mar-2015
Journal of Proteome Research
Omics methods: Towards a better prediction of the effects of substances at very low doses
It was possible to demonstrate, for example, that even low quantities of benzopyrene can have effects on the protein pattern and hence the metabolism and signal pathways in cells, even though the concentration is a hundred times below what is required to drive cells directly into apoptosis. This is the conclusion of studies undertaken by the Helmholtz Centre for Environmental Research, Dresden University of Technology, and the German Federal Institute for Risk Assessment.
Helmholtz Association

Contact: Tilo Arnhold
presse@ufz.de
49-341-235-1635
Helmholtz Centre for Environmental Research - UFZ

Public Release: 16-Mar-2015
Obese women 40 percent more likely to get cancer
Obese women have around a 40 percent greater risk of developing a weight-related cancer in their lifetime than women of a healthy weight.

Contact: Emily Head
emily.head@cancer.org.uk
44-203-469-6189
Cancer Research UK

Public Release: 16-Mar-2015
PLOS Computational Biology
New possibilities for the treatment of breast cancer arise, with the help of mathematics
Researchers of three of Switzerland's leading scientific institutions have brought to light a means of reprogramming a flawed immune response into an efficient anti-tumoral one by the results of a translational trial relating to breast cancer. Thanks to the innovative combination of mathematical modelization and experimentation, only 20 tests were necessary, whereas traditional experimentation would have required 596 tests to obtain the same results.

Contact: Ioannis Xenarios
Ioannis.Xenarios@isb-sib.ch
41-216-924-031
Swiss Institute of Bioinformatics

Public Release: 16-Mar-2015
Journal of the National Cancer Institute
Exercise slows tumor growth, improves chemotherapy in mouse cancers
In a study published in the March 16, 2015, issue of the Journal of the National Cancer Institute, researchers led by Duke Cancer Institute scientists studied the impact of exercise in models of breast cancer in mice. They found that exercise stimulated significant improvements in the number and function of blood vessels around the tumors, improving oxygen flow to the cancer site. When treated with chemotherapy, the tumors shrank markedly better than they did in sedentary animals.
US Department of Defense, NIH/National Cancer Institute

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

Public Release: 16-Mar-2015
Cell
Dialing a bespoke signal
Exploring the fundamental mechanism by which a cell-surface receptor transmits its signal, an international team of Ludwig researchers and their colleagues has established proof of concept for an entirely new approach to drug design. They report that a class of synthetic molecules known as diabodies can, from outside the cell, latch onto a target receptor and manipulate it in such a manner as to induce distinct and varying effects within cells and tissues.
Ludwig Cancer Research, Howard Hughes Medical Institute, Belgian Federal Science Policy Office, de Duve Institute at the Université catholique de Louvain, Fondation contre le Cancer in Belgium

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research

Public Release: 13-Mar-2015
Clinical Cancer Research
Genetically engineered immunotoxin shows early promise in patients with B-cell malignancies
DT2219, a new bispecific ligand-directed diphtheria toxin, was found to be safe and clinically effective in a small group of patients with relapsed/refractory B-cell malignancies, according to phase I clinical trial data.
National Institutes of Health, Randy Shaver Foundation, Lions Children's Cancer Fund, William Lawrence and Blanche Hughes Foundation

Contact: Lauren Riley
lauren.riley@aacr.org
215-446-7155
American Association for Cancer Research

Public Release: 13-Mar-2015
Molecular Cancer Research
Nodal alone does not produce anti-cancer effects
In a new study, standard treatments for metastatic melanoma are not effective against a growth factor protein called Nodal.
National Institutes of Health, NIH/National Cancer Institute, Eisenberg Research Scholar, Robert Kris Family

Contact: Peggy Murphy
pemurphy@luriechildrens.org
773-755-7485
Ann & Robert H. Lurie Children's Hospital of Chicago

Public Release: 13-Mar-2015
20th Annual Meeting of the National Comprehensive Cancer Network
NCCN publishes new guidelines for smoking cessation
To meet the needs of patients who are smokers at the time of a cancer diagnosis, the National Comprehensive Cancer Network (NCCN) has published the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Smoking Cessation. The NCCN Guidelines® for Smoking Cessation were presented on March 13, 2015, at the NCCN 20th Annual Conference: Advancing the Standard of Cancer Care. The guideline committee was chaired by Peter Shields, M.C., deputy director of The Ohio State University Comprehensive Cancer Center.

Contact: Amanda J Harper
amanda.harper2@osumc.edu
614-685-5420
Ohio State University Wexner Medical Center

Public Release: 13-Mar-2015
Food and Drug Law Journal
Georgetown legal scholar: E-cigarettes can be regulated now without more research
A legal scholar and tobacco control expert says he has developed a research-based roadmap that allows for the immediate regulation of e-cigarettes.

Contact: Karen Teber
km463@georgetown.edu
O'Neill Institute for National and Global Health Law

Public Release: 13-Mar-2015
Nature Communications
Organisms can keep gene expression in check: York U biologist
The current study, jointly conducted by York University and Columbia University researchers, suggests that Small Ubiquitin-like Modifier modifies proteins bound to active genes, in order to prevent unfettered gene over-expression that can be harmful to the organism.

Contact: Gloria Suhasini
suhasini@yorku.ca
416-736-2100 x22094
York University

Public Release: 12-Mar-2015
Cell Reports
Stem cells lurking in tumors can resist treatment
Scientists are eager to make use of stem cells' extraordinary power to transform into nearly any kind of cell, but that ability also is cause for concern in cancer treatment. For the first-time, scientists at Washington University School of Medicine in St. Louis have isolated treatment-resistant cancer stem cells from low-grade tumors.

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine

Public Release: 12-Mar-2015
JAMA Oncology
Germline TP53 mutations in patients with early-onset colorectal cancer
In a group of patients diagnosed with colorectal cancer at 40 or younger, 1.3 percent of the patients carried germline TP53 gene mutations, although none of the patients met the clinical criteria for an inherited cancer syndrome associated with higher lifetime risks of multiple cancers, according to a study published online by JAMA Oncology.

Contact: Anne Doerr
anne_doerr@dfci.harvard.edu
617-632-5665
The JAMA Network Journals

Public Release: 12-Mar-2015
Cell Reports
New genome-editing technology to help treat blood cancers
Melbourne researchers have developed a new genome editing technology that can target and kill blood cancer cells with high accuracy. Using the technology, researchers from the Walter and Eliza Hall Institute were able to kill human lymphoma cells by locating and deleting an essential gene for cancer cell survival.
National Health and Medical Research Council, Leukaemia Foundation, Kay Kendall Leukemia Fund and Victorian Government.

Contact: Liz Williams
williams@wehi.edu.au
61-428-034-089
Walter and Eliza Hall Institute

Public Release: 12-Mar-2015
Science
Magnetic brain stimulation
Magnetic nanoparticles could allow brain stimulation without wires.

Contact: Andrew Carleen
acarleen@mit.edu
617-253-1682
Massachusetts Institute of Technology

Public Release: 12-Mar-2015
Journal of American College of Surgeons
Liver-sparing operation associated with higher survival rates in cancer patients
A surgical approach in which a surgeon removes less than a lobe of the liver in a patient undergoing an operation for liver cancer is associated with lower mortality and complication rates, according to new study results published online as an 'article in press' in the Journal of the American College of Surgeons.
NIH/National Cancer Institute Cancer Center

Contact: Sally Garneski
pressinquiry@facs.org
312-202-5409
American College of Surgeons

Public Release: 12-Mar-2015
Proceedings of the National Academy of Sciences
Building a genomic GPS
A new 'app' for finding and mapping chromosomal loci using multicolored versions of CRISPR/Cas9, one of the hottest tools in biomedical research today, has been developed by scientists at the University of Massachusetts Medical School.
National Science Foundation

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School

Public Release: 12-Mar-2015
Cell
Case Western Reserve scientists find hidden meaning and 'speed limits' within genetic code
Case Western Reserve scientists have discovered that speed matters when it comes to how messenger RNA deciphers critical information within the genetic code -- the complex chain of instructions critical to sustaining life. The investigators' findings, which appear in the March 12 journal Cell, give scientists critical new information in determining how best to engage cells to treat illness -- and, ultimately, keep them from emerging in the first place.
National Institutes of Health

Contact: Jeannette Spalding
jeannette.spalding@case.edu
216-368-3004
Case Western Reserve University

Public Release: 12-Mar-2015
European Radiology
Low breast density in mammography worsens breast cancer prognosis
Very low mammographic breast density worsens the prognosis of breast cancer, according to a recent study from the University of Eastern Finland. Disease free survivals as well as overall life expectancies were significantly shorter in women with very low-density breasts in comparison to women with high-density breast tissue. The lower the breast tissue density, the less fibroglandular tissue there is compared to fat tissue.

Contact: Ritva Vanninen
ritva.vanninen@kuh.fi
358-447-113-303
University of Eastern Finland

Showing releases 101-125 out of 1261.

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