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Showing releases 101-125 out of 1182.

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Public Release: 2-May-2013
PLOS ONE
Making cancer less cancerous
Researchers at Johns Hopkins have identified a gene that, when repressed in tumor cells, puts a halt to cell growth and a range of processes needed for tumors to enlarge and spread to distant sites. The researchers hope that this so-called "master regulator" gene may be the key to developing a new treatment for tumors resistant to current drugs.
NIH/National Cancer Institute, Maryland Stem Cell Research Fund, Safeway Breast Cancer Foundation

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine

Public Release: 1-May-2013
New England Journal of Medicine
Computer algorithms help find cancer connections
Using powerful algorithms developed by computer scientists at Brown University, medical researchers have assembled the most complete genetic profile yet of acute myeloid leukemia, an aggressive form of blood cancer. Findings are reported in the New England Journal of Medicine.
National Institutes of Health

Contact: Kevin Stacey
kevin_stacey@brown.edu
401-863-3766
Brown University

Public Release: 1-May-2013
Biology of Blood and Marrow Transplantation
Researchers look to mathematics, nature, to understand the immune system and its role in cancer
Can patterns in tree branches or the meandering bends in a river provide clues that could lead to better cancer therapies? According to a new study from Virginia Commonwealth University Massey Cancer Center, these self-similar, repeating patterns in nature known as fractals help scientists better understand how the immune system is organized and may one day be used to help improve stem cell transplant outcomes in leukemia patients by predicting the probability of transplant complications.
NIH/National Cancer Institute

Contact: John Wallace
wallacej@vcu.edu
804-628-1550
Virginia Commonwealth University

Public Release: 1-May-2013
New England Journal of Medicine
Scientists assemble genetic playbook for acute leukemia
team of researchers led by Washington University School of Medicine in St. Louis has identified virtually all of the major mutations that drive acute myeloid leukemia, a fast-growing blood cancer in adults that often is difficult to treat.
National Institutes of Health, Barnes-Jewish Hospital Foundation

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine

Public Release: 1-May-2013
Nature
A paradigm shift in endometrial cancer
Results from the Cancer Genome Atlas Research Network may change the way endometrial cancers are classified and provide opportunities to test new treatment protocols for patients with this cancer.
National Institutes of Health

Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-534-2208
Brigham and Women's Hospital

Public Release: 1-May-2013
Journal of Clinical Investigation
JCI early table of contents for May 1, 2013
The following release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, May 1, 2013, in the JCI.

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 1-May-2013
Journal of Clinical Investigation
HPV leaves its mark in oropharyngeal squamous cell carcinoma
In this issue of the Journal of Clinical Investigation, Jochen Hess and colleagues identified a specific pattern of DNA modification that is dependent on the presence of HPV.
Dietmar Hopp Stiftung, Stiftung Tumorforschung Kopf-Hals, German Research Foundation

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 1-May-2013
Journal of Clinical Investigation
Searching for therapeutic synergy in primary effusion lymphoma
In this issue of the Journal of Clinical Investigation, Juan Carlos Ramos and colleagues at the University of Miami used an immunocompromised mouse model of PEL to determine the efficacy of Bortezomib/Vorinostat combination therapy.
NIH/Developmental Center for AIDS Research, Dwoskin Family, Recio Foundations

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 1-May-2013
Proceedings of the National Academy of Sciences
'Traffic' in our cells works both for and against us
A mechanism that permits essential substances to enter our cells while at the same time removing from them harmful components also has a "down side." This negative aspect prevents vital drugs, such as anti-cancer drugs, from achieving their designed functions, while also enabling bacterial cells to develop resistance to penetration of antibiotics.

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem

Public Release: 1-May-2013
Nature
Genomics to reshape endometrial cancer treatment
The most in-depth look yet at endometrial cancer shows that adding genomics-based testing to the standard diagnostic workup could change the recommended course of treatment for some women.
National Institutes of Health

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine

Public Release: 1-May-2013
Nature Medicine
Study finds key protein for firing up central nervous system inflammation
Scientists have identified an influential link in a chain of events that leads to autoimmune inflammation of the central nervous system in a mouse model of multiple sclerosis.

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center

Public Release: 1-May-2013
The Prostate
Taking cholesterol-lowering drugs may also reduce the risk of dying from prostate cancer: Study
Men with prostate cancer who take cholesterol-lowering drugs called statins are significantly less likely to die from their cancer than men who don't take such medication, according to study led by researchers at Fred Hutchinson Cancer Research Center. The findings are published online today in The Prostate.
NIH/National Cancer Institute, Dutch Cancer Society, Prostate Cancer Foundation, Fred Hutchinson Cancer Research Center

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center

Public Release: 1-May-2013
Nature
Scripps Research Institute scientists find dissimilar proteins evolved similar 7-part shape
Solving the structure of a critical human molecule involved in cancer, scientists at The Scripps Research Institute have found what they call a good example of structural conservation -- dissimilar genes that keep very similar shapes.
National Institutes of Health

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute

Public Release: 1-May-2013
Nature
Large genomic study identifies endometrial cancer subtypes, treatment opportunities
An analysis of endometrial cancers reveals genetic information that should improve diagnosis and guide treatments for women with an aggressive form of the disease.
NIH/National Cancer Institute

Contact: Caitlin Hool
hoolc@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center

Public Release: 1-May-2013
Nature Genetics
New genetic clues to breast and ovarian cancer
A major international study involving a Simon Fraser University scientist has found that sequence differences in a gene crucial to the maintenance of our chromosomes' integrity predispose us to certain cancers. Nature Genetics published the study on March 27, 2013.

Contact: Carol Thorbes
cthorbes@sfu.ca
778-782-3035
Simon Fraser University

Public Release: 1-May-2013
Nature
Endometrial and acute myeloid leukemia cancer genomes characterized
Two studies from the Cancer Genome Atlas program reveal details about the genomic landscapes of acute myeloid leukemia and endometrial cancer. Both provide new insights into the molecular underpinnings of these cancers with the potential to improve treatment. These studies represent the sixth and seventh in a series of genomes of at least 20 major cancers.
National Institutes of Health

Contact: NCI Press Office
ncipressofficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute

Public Release: 1-May-2013
AUA Annual Meeting 2013
Ferring to present safety analysis for FIRMAGON® (degarelix) at the AUA Annual Meeting
A safety analysis for FIRMAGON® (degarelix) will be presented at the annual meeting of the American Urology Association in San Diego, CA.
Ferring Pharmaceuticals

Contact: Molly Wilson
molly.wilson@toniclc.com
215-490-3009
Tonic Life Communications USA

Public Release: 1-May-2013
Sexually Transmitted Diseases
Self-collection of samples for HPV testing shows promise in detection of cervical cancer in Kenya
A study by researchers at the University of North Carolina at Chapel Hill suggests that training women to self-collect genital samples to test for human papillomavirus, the causative agent of cervical cancer, can increase the coverage rates of cervical cancer screening.

Contact: William Davis
william_davis@med.unc.edu
919-962-3405
University of North Carolina Health Care

Public Release: 30-Apr-2013
Sleep
Sleep duration associated with higher colorectal cancer risk
A new study is the first to report a significant positive association between long sleep duration and the development of colorectal cancer, especially among individuals who are overweight or snore regularly. The results raise the possibility that obstructive sleep apnea may contribute to cancer risk.
National Institutes of Health

Contact: Lynn Celmer
lcelmer@aasmnet.org
630-737-9700
American Academy of Sleep Medicine

Public Release: 30-Apr-2013
Clinical Cancer Research
Mayo Clinic finds experimental drug inhibits growth in all stages of common kidney cancer
Researchers at Mayo Clinic's campus in Florida have discovered a protein that is overly active in every human sample of kidney cancer they examined. They also found that an experimental drug designed to block the protein's activity significantly reduced tumor growth in animals when used alone. Combining it with another drug already used to treat the cancer improved the effectiveness of both.
NIH/National Cancer Institute

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic

Public Release: 30-Apr-2013
Nature Communications
Decoded: Molecular messages that tell prostate and breast cancers to spread
Cancer cells are wily, well-traveled adversaries, constantly side-stepping treatments to stop their spread. But for the first time, scientists at the University of Michigan have decoded the molecular chatter that ramps certain cancer cells into overdrive and can cause tumors to metastasize throughout the body.

Contact: Laura Bailey
baileylm@umich.edu
734-647-1848
University of Michigan

Public Release: 30-Apr-2013
Nature Immunology
T cells rely on 'rheostat' to help ensure that the immune response matches the threat
A properly functioning immune system is a lesson in balance, providing protection against disease without attacking healthy tissue. Work led by St. Jude Children's Research Hospital scientists and published recently in Nature Immunology has identified a mechanism that helps T cells find that sweet spot where the strength of the immune response matches the threat.
National Institutes of Health, American-Lebanese-Syrian Associated Charities

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital

Public Release: 30-Apr-2013
Proceedings of the National Academy of Sciences
Scientists find mutation driving pediatric brain tumors
A type of low-grade but sometimes lethal brain tumor in children has been found in many cases to contain an unusual mutation that may help to classify, diagnose and guide the treatment of the tumors, report scientists at Dana-Farber Cancer Institute.
National Institutes of Health, Pediatric Low Grade Astrocytoma Foundation

Contact: Anne Doerr
anne_doerr@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute

Public Release: 30-Apr-2013
Cancer Discovery
How some cancers 'poison the soil' to block metastasis
Cancer spread or metastasis can strike unprecedented fear in the minds of cancer patients. The "seed and the soil" hypothesis proposed by Stephen Paget in 1889 is now widely accepted to explain how cancer cells (seeds) are able to generate fertile soil (the microenvironment) in distant organs that promotes cancer's spread. However, this concept does not explain why some tumors do not spread or metastasize.
National Institutes of Health, Norwegian Cancer Society, Norwegian Research Council

Contact: Lauren Woods
Law2014@med.cornell.edu
646-317-7401
Weill Cornell Medical College

Public Release: 30-Apr-2013
Journal of Thoracic Oncology
Chemo, radiation followed by surgery improves survival in lung cancer patients
UI Health researchers report that a combination of chemotherapy and radiation followed by surgery in patients with stage 3 non-small cell lung cancer improves survival.

Contact: Sherri McGinnis Gonzalez
smcginn@uic.edu
312-996-8277
University of Illinois at Chicago

Showing releases 101-125 out of 1182.

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