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Public Release: 16-Jun-2015
World spends more than $200 billion to make countries healthier
The world invested more than $200 billion to improve health in lower-income countries over the past 15 years. Global health financing increased significantly after 2000, when the United Nations established the Millennium Development Goals, which included a strong focus on health. This trend in funding has only recently started to change, according to new research by the Institute for Health Metrics and Evaluation at the University of Washington.

Contact: Rhonda Stewart
Institute for Health Metrics and Evaluation

Public Release: 16-Jun-2015
Study shows benefit of higher quality screening colonoscopies
An analysis that included information from more than 57,000 screening colonoscopies suggests that higher adenoma detection rates may be associated with up to 50 percent to 60 percent lower lifetime colorectal cancer incidence and death without higher overall costs, despite a higher number of colonoscopies and potential complications, according to a study in the June 16 issue of JAMA.

Contact: Reinier G.S. Meester, M.Sc.
The JAMA Network Journals

Public Release: 16-Jun-2015
Journal of Clinical Endocrinology and Metabolism
Prenatal DDT exposure tied to nearly 4-fold increase in breast cancer risk
Women who were exposed to higher levels of the pesticide DDT in utero were nearly four times more likely to be diagnosed with breast cancer as adults than women who were exposed to lower levels before birth, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Contact: Jenni Glenn Gingery
The Endocrine Society

Public Release: 16-Jun-2015
Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research
Drug trials in pet dogs with cancer may speed advances in human oncology
Pet dogs may be humans' best friends in a new arena of life: cancer treatment, said University of Illinois veterinary clinical medicine professor Timothy Fan. Physiological similarities between dogs and humans, and conserved genetics between some dog and human cancers, can allow pet dogs to serve as useful models for studying new cancer drugs, he said.

Contact: Diana Yates
University of Illinois at Urbana-Champaign

Public Release: 16-Jun-2015
Translational Psychiatry
Early behavior problems may be linked to 'aging' biomarkers in preschoolers
Preschoolers with oppositional defiant behavior are more likely to have shorter telomeres, a hallmark of cellular aging, which in adults is associated with increased risk for chronic diseases and conditions like diabetes, obesity and cancer.
National Institutes of Health, Hellman Family Foundation, Robert Wood Johnson, NASPGHAN Foundation, UCSF CTSI-SOS Award

Contact: Suzanne Leigh
University of California - San Francisco

Public Release: 16-Jun-2015
Adoptive immunotherapy may help treat more types of cancer if new approaches are explored
In a special issue of Immunotherapy, leading experts provide in-depth review of innovative strategies that may further the success of adoptive cell immunotherapy as a cancer treatment.

Contact: Leela Ripton
Future Science Group

Public Release: 16-Jun-2015
Returning killer T cells back to barracks could improve vaccines
Just as militaries need to have trained, experienced soldiers ready for future wars, making sure that the immune system has enough battle-ready T cells on hand is important for fast-acting, more effective vaccines, according to Penn State researchers.
National Institutes of Health, US Department of Agriculture, American Association of Immunologists

Contact: Matt Swayne
Penn State

Public Release: 16-Jun-2015
Cancer Research
Protein plays key role in spread of breast cancer
For breast cancer to be fatal, the tumor has to send out metastases to other parts of the body. The cancer cells are spread via the blood vessels, and a research team at Lund University in Sweden has now proven that the protein ALK1 determines the extent of the tumor's spread in the body. The higher the levels of the protein on the surface of the blood vessels, the greater their permeability to tumor cells and therefore the greater the risk of metastases.

Contact: Kristian Pietras
Lund University

Public Release: 16-Jun-2015
Device allows evaluation of the efficacy, toxicity of drugs metabolized through the liver
Researchers from the Massachusetts General Hospital Center for Engineering in Medicine have developed a novel approach that dramatically simplifies the evaluation of the liver's drug-metabolizing activity and the potential toxic effects of the products of that activity on other organs.
National Institutes of Health

Contact: Noah Brown
Massachusetts General Hospital

Public Release: 16-Jun-2015
Cell Stem Cell
Researchers identify new stem cell population important in the growth of colon cancer
Researchers at Lawson Health Research Institute have identified a previously unknown, long-lived radiation-resistant stem cell population in the colon. Most importantly, they also found that these stem cells can give rise to colonic tumors and sustain their growth. The findings, which are published in the prominent journal Cell Stem Cell, will significantly change the way we study and treat colon cancer.

Contact: Julia Capaldi
519-685-8500 x75616
Lawson Health Research Institute

Public Release: 15-Jun-2015
Nature Materials
Scientists are first to see elements transform at atomic scale
Chemists have witnessed atoms of one chemical element morph into another element for the first time ever. The isotope they studied -- iodine-125 -- is commonly used to treat cancer and this breakthrough unexpectedly revealed a possible new way to irradiate tumors more effectively.
National Science Foundation, US Department of Energy, European Research Council, Royal Society

Contact: Kim Thurler
Tufts University

Public Release: 15-Jun-2015
Cancer Research
ALK1 protein may play a role in breast cancer metastasis
Breast cancer patients with high levels of the protein activin-like receptor kinase (ALK1) in the blood vessels of their tumors were more likely to develop metastatic disease. This makes inhibition of the ALK1 pathway a possible new target for the treatment of metastatic breast cancer.
European Research Council, Swedish Research Council, Swedish Cancer Society, STARGET Consortium, BioCARE, Lund University, BRECT, Karolinska Institute, Stockholm County Council, Karolinska University Hospital

Contact: Lauren Riley
American Association for Cancer Research

Public Release: 15-Jun-2015
Clinical Cancer Research
Blood antibodies may predict HPV-positive oropharyngeal cancer survival
The presence of certain human papillomavirus (HPV)-16 antibodies in the blood was associated with improved rates of survival among patients with HPV-related oropharyngeal carcinoma.
National Institutes of Health, MD Anderson Cancer Center, Arizona State University, NIH/NCI Early Detection Research Network, Stiefel Oropharyngeal Research Fund

Contact: Lauren Riley
American Association for Cancer Research

Public Release: 15-Jun-2015
JAMA Internal Medicine
Study estimates deaths attributable to cigarettes for 12 smoking-related cancers
Researchers estimate that 48.5 percent of the nearly 346,000 deaths from 12 cancers among adults 35 and older in 2011 were attributable to cigarette smoking, according to an article published online by JAMA Internal Medicine.

Contact: Kathi Di Nicola
The JAMA Network Journals

Public Release: 15-Jun-2015
Nature Genetics
Scientists find genetic variants key to understanding origins of ovarian cancer
New research by an international team including Keck Medicine of USC scientists is bringing the origins of ovarian cancer into sharper focus. The study, published online June 15 in the peer-reviewed journal Nature Genetics, highlights the discovery of three genetic variants associated with mucinous ovarian carcinomas (MOCs), offering the first evidence of genetic susceptibility in this type of ovarian cancer.
European Commission's Seventh Framework Programme grant, Ovarian Cancer Association Consortium, US National Cancer Institute GAME-ON Post-GWAS initiative, American Cancer Society, Canadian Institutes of Health Research

Contact: Leslie Ridgeway
University of Southern California - Health Sciences

Public Release: 15-Jun-2015
JAMA Internal Medicine
Active clinician support and assistance are critical to successfully quitting smoking
A new study from a Massachusetts General Hospital research team finds that, while primary care providers' simply asking patients with high-risk smoking histories about their smoking status did not increase patients' likelihood of quitting, providing more direct assistance -- such as talking about how to quit, recommending or prescribing nicotine replacement or pharmaceutical aids, and following up on recommendations -- significantly improved patients' success in becoming smoke-free.
American Cancer Society, American College of Radiology Imaging Network/National Lung Screening Trial

Contact: Terri Ogan
Massachusetts General Hospital

Public Release: 15-Jun-2015
Microbe mobilizes 'iron shield' to block arsenic uptake in rice
University of Delaware researchers have discovered a soil microbe that mobilizes an 'iron shield' to block the uptake of toxic arsenic in rice. The UD finding gives hope that a natural, low-cost solution -- a probiotic for rice plants -- may be in sight to protect this global food source from accumulating harmful levels of one of the deadliest poisons on the planet. Rice currently is a staple in the diet of more than half the world's population.
National Science Foundation

Contact: Andrea Boyle Tippett
University of Delaware

Public Release: 15-Jun-2015
Journal of Clinical Investigation
'Death-associated protein' promotes cancer growth in most aggressive breast cancers
Although traditionally understood to induce death in cancer cells, researchers at The University of Texas MD Anderson Cancer Center have discovered that the DAPK1 protein is actually essential for growth in breast and other cancers with mutations in the TP53 gene. This discovery indicates DAPK1 may be a promising new therapeutic target for many of the most aggressive cancers.

Contact: Clayton R. Boldt
University of Texas M. D. Anderson Cancer Center

Public Release: 15-Jun-2015
Cancer Prevention Research
UA researchers discover component of cinnamon prevents colorectal cancer in mice
A study conducted by University of Arizona researchers from the College of Pharmacy and the UA Cancer Center proved that adding cinnamaldehyde, the compound that gives cinnamon its distinctive flavor and smell, to the diet of mice protected the mice against colorectal cancer.
National Institutes of Health, the University of Arizona Cancer Center

Contact: Karin Lorentzen
University of Arizona, College of Pharmacy

Public Release: 15-Jun-2015
Cancer Research
Avocados may hold the answer to beating leukemia
Rich, creamy, nutritious and now cancer fighting. New research reveals that molecules derived from avocados could be effective in treating a form of cancer.
University of Waterloo, Leukemia and Lymphoma Society of Canada

Contact: Nick Manning
University of Waterloo

Public Release: 15-Jun-2015
Nature Methods
First full genome of a living organism assembled using technology the size of smartphone
Researchers in Canada and the UK have for the first time sequenced and assembled de novo the full genome of a living organism, the bacteria Escherichia coli, using Oxford Nanopore's MinIONTM device, a genome sequencer that can fit in the palm of your hand.

Contact: Christopher Needles
Ontario Institute for Cancer Research

Public Release: 15-Jun-2015
PLOS Pathogens
How the Epstein-Barr virus hides in human cells
Scientists at Helmholtz Zentrum München have now discovered how Epstein-Barr virus (EBV) conceals itself in human cells. A main culprit for its bad visibility by the immune system is the viral protein LMP2A. As published in the scientific journal PLOS Pathogens, the protein helps EBV-infected cells hide from T cells. This camouflage through the LMP2A protein may play a major role in the causation of cancer by EBV.

Contact: Dr. Andreas Moosmann
Helmholtz Zentrum München - German Research Center for Environmental Health

Public Release: 12-Jun-2015
Mini-breast grown in Petri dishes -- a new tool for cancer research
About 70,000 Women are diagnosed with breast cancer every year in Germany alone. Despite significant progress in the treatment of common types of breast cancer, some aggressive subtypes are poorly understood and remain incurable. A new experimental model opens new avenues for mammary gland biology and basic breast cancer research. Researchers at the Helmholtz Center in Munich are now able to create three-dimensional organoid-structures that recapitulate normal breast development and function from single patient-derived cells.
Max Eder Grant of the German Cancer Aid Foundation

Contact: Dr. Christina Scheel
Helmholtz Zentrum München - German Research Center for Environmental Health

Public Release: 12-Jun-2015
Nature Communications
Study links gene to aggressive form of brain cancer
Scientists have identified a gene mutation linked to the development of an aggressive form of brain cancer. Researchers found that errors in a gene known as TCF12 -- which plays a key role in the formation of the embryonic brain are associated with more aggressive forms of a disease called anaplastic oligodendroglioma.
Investissements d'avenir, Génome Québec

Contact: Henry French
Institute of Cancer Research

Public Release: 11-Jun-2015
European Conferences on Biomedical Optics 2015
Journal of Biomedical Optics
'Light for Life' section marks Year of Light, parallels Biomedical Optics conference
A special section published this month in the Journal of Biomedical Optics titled 'Light for Life' celebrates the International Year of Light and parallels a dedicated session at the European Conference of Biomedical Optics, set for June 21-25, in Munich. The journal is published by SPIE, the international society for optics and photonics, a sponsor of the conference.

Contact: Amy Nelson
SPIE--International Society for Optics and Photonics

Showing releases 101-125 out of 1375.

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