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Showing releases 1001-1025 out of 1182. << < 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 > >>
Public Release: 13-Dec-2012
 Cancer ResearchUAlberta medical researchers discover new potential chemotherapy Medical researchers at the University of Alberta have discovered that knocking out a particular "partner" gene is the Achilles' heel of some cancers. 
Canadian Institutes of Health Research
Contact: Raquel Maurier
Public Release: 13-Dec-2012
ScienceCancer scientists identify a new layer of complexity within human colon cancer Cancer scientists led by Dr. John Dick at the Princess Margaret Cancer Centre have found a way to follow single tumor cells and observe their growth over time. The team discovered that biological factors and cell behavior -- not only genes -- drive tumor growth, contributing to therapy failure and relapse. Contact: Jane Finlayson
Public Release: 13-Dec-2012
EMBO Molecular MedicineCancer stem cells isolated from kidney tumors Scientists have isolated cancer stem cells that lead to the growth of Wilms' tumors, a type of cancer typically found in the kidneys of young children. The researchers have used these cancer stem cells to test a new therapeutic approach that one day might be used to treat some of the more aggressive types of this disease. The results are published online in EMBO Molecular Medicine. Contact: Barry Whyte
Public Release: 13-Dec-2012
Cancer DiscoveryNew screening approach identified potential drug combos for difficult-to-treat melanomas A novel approach to identifying potential anticancer drug combinations revealed that pairing cholesterol-reducing drugs called statins with cyclin-dependent kinase inhibitors might provide an effective approach to treating intractable melanomas driven by mutations in the NRAS and KRAS gene. Contact: Jeremy Moore
Public Release: 13-Dec-2012
American Journal of Human GeneticsCleveland Clinic researcher identifies 2 new genetic mutations associated with Cowden syndrome Cleveland Clinic researchers from the Lerner Research Institute have uncovered two new genes associated with Cowden syndrome according to a new study, published today in the online version of the American Journal of Human Genetics. Contact: Laura Ambro
Public Release: 13-Dec-2012
Menopause: The Journal of The North American Menopause SocietyNew hormone therapy shows promise for menopausal symptoms in animal model Investigators at Wake Forest Baptist Medical Center have concluded research on a new postmenopausal hormone therapy that shows promise as an effective treatment for menopausal symptoms and the prevention of osteoporosis without increasing the risk for heart disease or breast cancer.
Pfizer
Contact: Bonnie Davis
Public Release: 13-Dec-2012
Journal of Occupational Medicine and ToxicologyLarge study identifies risk factors for multiple myeloma New research published in Biomed Central's open access journal Journal of Occupational Medicine and Toxicology provides a large (from 22 centers across Europe), matched control study into lifetime risk of multiple myeloma. They find that risk of Multiple myeloma is related to farm work, printing and cleaning. But although exposure to pesticides seemed to be a risk, exposure to organic solvents was not. Contact: Hilary Glover
Public Release: 12-Dec-2012
Journal of Clinical OncologyOlder and younger chronic leukemia patients may need different therapy Age is usually not considered when determining treatment for people with chronic lymphocytic leukemia (CLL), but a new study indicates that older patients with CLL may require different therapy than younger patients. The findings highlight the importance of enrolling older patients on CLL trials and of developing trials that specifically target older patients.
NIH/National Cancer Institute, Leukemia and Lymphoma Society, Harry Mangurian Foundation
Contact: Darrell E. Ward
Public Release: 12-Dec-2012
NatureStudy paves way to design drugs aimed at multiple protein targets at once Pharmaceutical chemists had suggested that the objective of a drug hitting multiple targets simultaneously is impossible and unlikely to succeed. This study shows how to efficiently and effectively make designer drugs that can do that.
National Institutes of Health
Contact: Les Lang
Public Release: 12-Dec-2012
New England Journal of MedicinePre-transplant umbilical cord blood expansion speeds establishment of new blood supply in patients Donated umbilical cord blood establishes a new blood supply in patients more quickly after transplantation when it is first expanded in the lab on a bed of cells that mimics conditions in the bone marrow, researchers report in the Dec. 13 edition of the New England Journal of Medicine. Contact: Scott Merville
Public Release: 12-Dec-2012
The Journal of Molecular DiagnosticsNovel test identifies patients most likely to benefit from ALK inhibition therapy Researchers have now developed and tested a promising new method for screening anaplastic lymphoma kinase fusions in non-small cell lung carcinoma. This new diagnostic assay offers a cost-effective and easy-to-perform alternative to existing tests. Contact: David Sampson
Public Release: 12-Dec-2012
PLOS ONEVegetable compound could become ingredient to treating leukemia A concentrated form of a compound called sulforaphane found in broccoli and other cruciferous vegetables has been shown to reduce the number of acute lymphoblastic leukemia cells in the lab setting, said researchers at Baylor College of Medicine. The findings appear in the current edition of PLOS ONE. Contact: Graciela Gutierrez
Public Release: 12-Dec-2012
American Journal of PathologyPreviously unknown mechanism identified in oncogene-induced senescence Cell aging, or cellular senescence, has an important role in the natural physiological response to tumor development. Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced senescence could play a key role in future cancer therapy. Researchers have now identified a previously unknown mechanism in the regulation of OIS. Contact: David Sampson
Public Release: 12-Dec-2012
Emerging Infectious DiseasesEmerging virus in raccoons may provide cancer clues Rare brain tumors emerging among raccoons in Northern California and Oregon may be linked to a previously unidentified virus discovered by a team of researchers, led by scientists from the University of California, Davis.
Bernice Barbour Foundation, University of California, Davis Center for Companion Animal Health, Meadowview Foundation
Contact: Kat Kerlin
Public Release: 12-Dec-2012
Journal of Biological ChemistryMicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer A University of Colorado Cancer Center study published in the December issue of the Journal of Biological Chemistry shows that in medulloblastoma, a malignant brain tumor of children, microRNA-218 is especially low. The article also shows that adding microRNA-218 to neural stem cells engineered to develop medulloblastoma decreases the development of the cancer.
National Institutes of Health
Contact: Garth Sundem
Public Release: 12-Dec-2012
Journal of the Americal Chemical SocietyA second ascent of chemistry's Mt. Everest In science's equivalent of ascending Mt. Everest, researchers are reporting success in one of the most difficult challenges in synthetic chemistry -- a field in which scientists reproduce natural and other substances from jars of chemicals in a lab. The feat, reported in the Journal of the American Chemical Society, involved synthesis of a rare substance with promising in vitro anti-cancer effects found naturally in tiny amounts in a Chinese medicinal herb. Contact: Michael Bernstein
Public Release: 12-Dec-2012
Journal of Biological ChemistryProtein strongest just before death Researchers at Michigan State University have discovered a protein that does its best work with one foot in the grave.
National Institutes of Health
Contact: Layne Cameron
Public Release: 12-Dec-2012
LeukemiaSingapore scientists identify new biomarker for cancer in bone marrow Singapore scientists have identified FAIM, a molecule that typically prevents cell death, as a potential biomarker to identify an incurable form of cancer in the bone marrow. Patients with this form of cancer usually do not get cured with current standard treatments such as chemotherapy and stem cell transplantation, with an average survival of only about four years.
Agency for Science, Technology & Research (A*STAR)
Contact: Vithya Selvam
Public Release: 12-Dec-2012
Breast Cancer Research and TreatmentDelaying childbirth may reduce risk of an aggressive form of breast cancer Younger women who wait at least 15 years after their first menstrual period to give birth to their first child may reduce their risk of an aggressive form of breast cancer by up to 60 percent, according to a Fred Hutchinson Cancer Research Center study.
NIH/National Cancer Institute, US Department of Defense Breast Cancer Research Program
Contact: Kristen Woodward
Public Release: 12-Dec-2012
Journal of the National Cancer InstitutePatients with family history of colorectal cancer may be at risk for aggressive form of the disease When people with a family history of colorectal cancer develop the disease, their tumors often carry a molecular sign that the cancer could be life-threatening, report Dana-Farber Cancer Institute scientists. The finding suggests it may be possible to identify colorectal cancer patients who should receive more aggressive therapies and whose relatives may be at increased risk for the aggressive form of the disease.
National Institutes of Health, Bennett Family Fund for Targeted Therapies Research, National Colorectal Cancer Research Alliance
Contact: Bill Schaller
Public Release: 11-Dec-2012
54th Annual Meeting of the American Society of HematologyWeekly dose reduces targeted drug's side effects, but not its activity against ALL A potent chemotherapy agent wrapped within a monoclonal antibody selectively destroys the malignant cells responsible for acute lymphocytic leukemia in either weekly or monthly dosing, researchers report at the 54th ASH Annual Meeting and Exposition. Contact: Scott Merville
Public Release: 11-Dec-2012
54th Annual Meeting of the American Society of HematologyPotential gene therapy approach to sickle cell disease highlighted at American Society of Hematology Researchers at Dana-Farber/Children's Hospital Cancer Center have taken the first preliminary steps toward developing a form of gene therapy for sickle cell disease.
NIH/National Heart, Lung and Blood Institute, NIH/National Institute of Diabetes and Digestive and Kidney Diseases, Howard Hughes Medical Institute
Contact: Rob Graham
Public Release: 11-Dec-2012
Proceedings of the National Academy of SciencesWhat causes hot flushes during menopause? A UA research team has identified a region in the brain that may trigger the uncomfortable surges of heat most women experience in the first few years of menopause. Although the results are not yet directly applicable in helping affected individuals, they provide better understanding of the biological mechanisms involved, a necessary first step for treatments to be developed.
National Institutes of Health, NIH/National Institute on Aging
Contact: Daniel Stolte
Public Release: 11-Dec-2012
Journal of Biological ChemistryKeck School of Medicine of USC researchers find clue to how Hepatitis C virus harms liver Researchers at the University of Southern California have discovered a trigger by which the Hepatitis C virus enters liver cells -- shedding light on how this serious and potentially deadly virus can begin to damage the liver.
National Institutes of Health
Contact: Leslie Ridgeway
Public Release: 11-Dec-2012
Archives of Pathology & Laboratory MedicineThe current state of lung cancer treatment "We're in a new paradigm in which we realize this top cause of cancer deaths is actually a number of related diseases, each potentially with its own cause and cure," Bunn says.
NIH/National Cancer Institute, National Institutes of Health
Contact: Garth Sundem
Showing releases 1001-1025 out of 1182. << < 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 > >>
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