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Showing releases 1001-1025 out of 1231.

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Public Release: 2-Dec-2013
Journal of Clinical Investigation
Blocking antioxidants in cancer cells reduces tumor growth in mice
In this issue of the Journal of Clinical Investigation, Navdeep Chandel and colleagues from Northwestern University report the effects of a SOD1 pharmacological inhibitor on non-small-cell lung cancer cells.
National Institutes of Health, LUNGevity Foundation, Consortium of Independent Lung Health Organizations

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 2-Dec-2013
Journal of Clinical Investigation
Predicting outcome for high-dose IL-2 therapy in cancer patients
Previous studies indicate that regulatory T cell (Treg) populations increase in patients undergoing HD IL-2 therapy, and in this issue of the Journal of Clinical Investigation, Lazlo Radvanyi and colleagues at M.D. Anderson Cancer Center performed an in depth analysis of Treg populations in melanoma patients undergoing HD IL-2 therapy.
Prometheus Therapeutics and Diagnostics, Novartis, NIH/National Cancer Institute, Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 2-Dec-2013
Proceedings of the National Academy of Sciences
Difficult dance steps: Team learns how membrane transporter moves
Researchers have tried for decades to understand the undulations and gyrations that allow transport proteins to shuttle molecules from one side of a cell membrane to the other. Now scientists report that they have found a way to penetrate the mystery. They have worked out every step in the molecular dance that enables one such transporter to do its job.
National Institutes of Health

Contact: Diana Yates
University of Illinois at Urbana-Champaign

Public Release: 2-Dec-2013
Proceedings of the National Academy of Sciences
Burmese python genome reveals extreme adaptation
Scientists from the University of Colorado School of Medicine who sequenced the genome of the Burmese python have discovered large numbers of rapidly evolved genes in snakes.

Contact: david kelly
University of Colorado Denver

Public Release: 2-Dec-2013
Journal of Clinical Investigation
JCI early table of contents for Dec. 2, 2013
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Dec. 2, 2013, in the JCI: "Predicting outcome for high-dose IL-2 therapy in cancer patients," "Blocking antioxidants in cancer cells reduces tumor growth in mice," "Platelets mediate lympho-venous hemostasis to maintain blood-lymphatic separation throughout life," "Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3-beta," "Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity," and more.

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 2-Dec-2013
Researchers turn to machines to identify breast cancer type
Team from University of Alberta and Alberta Health Services develop new technique to determine if tumours fed by estrogen.

Contact: Bryan Alary
University of Alberta

Public Release: 2-Dec-2013
Journal of Nuclear Medicine
Treatment plans for brain metastases more accurately determined with aid of molecular imaging trace
Imaging with the molecular imaging tracer 18F-FDOPA can help distinguish radiation-induced lesions from new tumor growth in patients who have been treated with radiation for brain metastases, according to new research published in The Journal of Nuclear Medicine. Using this amino acid tracer, researchers found that physicians could accurately differentiate the two types of lesions 83 percent of the time. Progression-free survival could also be predicted through evaluating the 18F-FDOPA imaging results.

Contact: Susan Martonik
Society of Nuclear Medicine

Public Release: 2-Dec-2013
The importance of standardizing drug screening studies
A bioinformatics expert at the IRCM, Benjamin Haibe-Kains, recently published an article stressing the importance of standardizing drug screening studies in the prestigious scientific journal Nature. The study supports the need for further development and standardization to improve the reproducibility of drug screening studies, as they are important in identifying new therapeutic agents and their potential combinations with existing drugs.

Contact: Julie Langelier
Institut de recherches cliniques de Montreal

Public Release: 1-Dec-2013
Nature Medicine
Colon cancer researchers target stem cells, discover viable new therapeutic path
Scientists and surgeons at Princess Margaret Cancer Centre have discovered a promising new approach to treating colorectal cancer by disarming the gene that drives self-renewal in stem cells that are the root cause of disease, resistance to treatment and relapse. Colorectal cancer is the third leading cause of cancer-related death in the Western world.

Contact: Jane Finlayson
University Health Network

Public Release: 30-Nov-2013
New family of proteins linked to major role in cancer
Scientists have described a new family of proteins that appear to play a key role in cancer and might be targets for future cancer drugs. A major new study in the journal Nature sets out the structure of the new family, called glutamate intramembrane proteases -- the founding member of which plays a critical role in transforming healthy cells into cancer cells.

Contact: Henry French
Institute of Cancer Research

Public Release: 29-Nov-2013
Joint EORTC-ESTRO session to focus on current developments in soft tissue sarcoma treatment
The EORTC will host a joint session with ESTRO at ESTRO 33 focusing on current developments in soft tissue sarcoma treatment. It will take place from 14:30– 16:00 on Monday, 07 April 2014 in Vienna, Austria and will be co-chaired by Professors Jean-Yves Blay of the Centre Leon Berard in Lyon, France and past EORTC President and Philippe Maingon of the Centre Georges-François-Leclerc in Dijon, France, and Chair of the EORTC Radiation Oncology Group.

Contact: John Bean
European Organisation for Research and Treatment of Cancer

Public Release: 29-Nov-2013
Nature Communications
Cyclin D1 governs microRNA processing in breast cancer
A protein that helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA, according to new research from Thomas Jefferson University.

Contact: Edyta Zielinska
Thomas Jefferson University

Public Release: 28-Nov-2013
Biomedical Materials
Bone grafting improvements with the help of sea coral
Sea coral could soon be used more extensively in bone grafting procedures thanks to new research that has refined the material's properties and made it more compatible with natural bone.

Contact: Michael Bishop
Institute of Physics

Public Release: 28-Nov-2013
Science Signaling
Methylation signaling controls angiogenesis and cancer growth
A study led by researchers at Boston University School of Medicine demonstrates a new mechanism involving a signaling protein and its receptor that may block the formation of new blood vessels and cancer growth. The findings are published in the December issue of Science Signaling.
National Institutes of Health, Massachusetts Lions Foundation

Contact: Jenny Eriksen
Boston University Medical Center

Public Release: 28-Nov-2013
High cholesterol fuels the growth and spread of breast cancer
A byproduct of cholesterol functions like the hormone estrogen to fuel the growth and spread of the most common types of breast cancers, researchers at the Duke Cancer Institute report.
National Institutes of Health

Contact: Sarah Avery
Duke University Medical Center

Public Release: 28-Nov-2013
Nucleic Acids Research
CNIO scientists create the first large catalog of interactions between drugs and proteins
A Spanish National Cancer Research Centre work, led by Alfonso Valencia, Vice-Director of Basic Research, and Michael L. Tress, brings together the biggest collection of interactions between pharmacological molecules, including other compounds, and proteins. The catalog includes 16,600 compounds, of which 1,300 contain pharmacological descriptions, and 500,000 interactions that witness the extensive social network that governs the functioning of organisms. The information is available to the entire scientific community via the public FireDB database.

Contact: Nuria Noriega
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 28-Nov-2013
Iron-based process promises greener, cheaper and safer drug and perfume production
University of Toronto researchers have developed a series of techniques to create a variety of very active iron-based catalysts necessary to produce the alcohols and amines used in the drug and perfume industry. The new synthetic methods promise to be safer and more economical and environmentally friendly than traditional industrial processes.
Natural Sciences and Engineering Research Council of Canada, GreenCentre Canada

Contact: Sean Bettam
University of Toronto

Public Release: 28-Nov-2013
Journal of the National Cancer Institute
Why tumors become resistant to chemotherapy?
IDIBELL researchers describe one of the causes that make a patient with colon cancer that responds well to initial chemotherapy, becomes resistant when the tumor reappears. The results of the study have been published at the Journal of The National Cancer Institute.
European Community's Seventh Framework Programme

Contact: Arantxa Mena
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 27-Nov-2013
Science Translational Medicine
Scientists develop way to successfully give nanoparticle therapeutics orally
Researchers at Brigham and Women's Hospital and Massachusetts Institute of Technology are the first to report in the field of nanomedicine a new type of nanoparticle that can be successfully absorbed through the digestive tract.
National Institutes of Health

Contact: Marjorie Montemayor-Quellenberg
Brigham and Women's Hospital

Public Release: 27-Nov-2013
Cancer Epidemiology, Biomarkers & Prevention
Negative BRCA testing may not always imply lowered breast cancer risk
Women who are members of families with BRCA2 mutations but who test negative for the family-specific BRCA2 mutations are still at greater risk for developing breast cancer compared with women in the general population, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
NIH/National Institute for Health Research

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 27-Nov-2013
Annals of Oncology
Global study reveals pandemic of untreated cancer pain due to over-regulation of pain medicines
A ground-breaking international collaborative survey, published in Annals of Oncology, shows that more than half of the world's population live in countries where regulations that aim to stem drug misuse leave cancer patients without access to opioid medicines for managing cancer pain.

Contact: Vanessa Pavinato
European Society for Medical Oncology

Public Release: 27-Nov-2013
Nature Cell Biology
MD Anderson researchers identify a rescuer for vital tumor-suppressor
The tumor-suppessing protein PTEN is absent in many cancers, yet defects in the PTEN gene do not account for this disappearance. MD Anderson researchers identified an enzyme that keep PTEN from being fed to the cell's protein-recycling mechanism.
NIH/National Cancer Institute, Cancer Prevention and Research Institute of Texas

Contact: Scott Merville
University of Texas M. D. Anderson Cancer Center

Public Release: 26-Nov-2013
Breast Cancer Research
High-fat diet during puberty speeds up breast cancer development
New findings show that eating a high-fat diet beginning at puberty speeds up the development of breast cancer and may actually increase the risk of cancer similar to a type often found in younger adult women.
NIH/National Institute of Environmental Health, NIH/National Cancer Institute

Contact: Sarina Gleason
Michigan State University

Public Release: 26-Nov-2013
Genes & Development
Scientists discover how leukemia cells exploit 'enhancer' DNA elements to cause lethal disease
A team of researchers at Cold Spring Harbor Laboratory has identified a leukemia-specific stretch of DNA called an enhancer element that enables cancerous blood cells to proliferate in acute myeloid leukemia, a devastating cancer that is incurable in 70 percent of patients. Just as important, the findings offer a mechanistic insight into how a new class of promising drugs -- one version of which is already in human clinical trials -- appears to halt the growth of cancer cells so effectively.
National Institutes of Health

Contact: Jaclyn Jansen
Cold Spring Harbor Laboratory

Public Release: 26-Nov-2013
Cell Stem Cell
Researchers at Penn uncover mechanism behind blood stem cells' longevity
Researchers have long wondered what allows blood stem cells to persist for decades, when their progeny last for days, weeks or months before they need to be replaced. Now, a study from the University of Pennsylvania has uncovered one of the mechanisms that allow these stem cells to keep dividing in perpetuity.
National Institutes of Health, Human Frontier Science Program, American Heart Association

Contact: Evan Lerner
University of Pennsylvania

Showing releases 1001-1025 out of 1231.

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