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Public Release: 30-May-2014
ASCO 50th Annual Meeting
Phase I study of DMOT4039A in patients with pancreatic or ovarian cancer
In this early clinical trial with the goal of identifying possible risks and defining likely dosages, the drug was well tolerated and in some patients showed initial evidence of anti-cancer activity.

Contact: Erika Matich
University of Colorado Denver

Public Release: 30-May-2014
ASCO 50th Annual Meeting
Stopping statins may benefit terminally ill patients
Results presented today at ASCO 2014 and at the European Association of Palliative Care Research Conference show that stopping statins for cholesterol management in the late stages of cancer or other terminal illnesses may offer quality-of-life and even life-extending benefits. The results highlight the larger question of when, if ever, it is appropriate in patients with life-limiting illnesses to discontinue medications prescribed for other conditions that will likely not lead to their death.
National Institute of Nursing Research

Contact: Erika Matich
University of Colorado Denver

Public Release: 30-May-2014
ASCO 50th Annual Meeting
New drug treatment helps prevent early menopause in breast cancer patients
Among young women treated for breast cancer, one of the most distressing side effects of chemotherapy is early menopause. But a major clinical trial has found that the risk of early menopause can be significantly reduced by adding a drug called goserelin to the chemotherapy regimen. Also, women who took goserelin were more likely to get pregnant and deliver a healthy baby.
NIH/National Cancer Institute

Contact: Jim Ritter
Loyola University Health System

Public Release: 30-May-2014
Study explains how green tea could reduce pancreatic cancer risk
New study explains how green tea changed the metabolism of pancreatic cancer cells, opening a new area in cancer-fighting research.
National Institutes of Health, Hirshberg Foundation for Pancreatic Cancer Research

Contact: Laura Mecoy
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)

Public Release: 30-May-2014
One cell's meat is another cell's poison
The protein JAK2 is of special therapeutic significance: its inactivation is believed to destroy cancer cells. However, the effect of JAK2 inhibition on healthy cells is so far unknown. Scientists at the Vetmeduni Vienna show that the loss of JAK2 causes healthy blood cells to disappear while cancer cells preserve their growth potential. Future studies will reveal whether the findings are going to change treatment in humans. The results were published in the journal Leukemia.

Contact: Veronika Sexl
University of Veterinary Medicine -- Vienna

Public Release: 30-May-2014
ASCO 50th Annual Meeting
Myriad presents data on BRACAnalysis CDx and HRD at 2014 ASCO meeting
New data presented at ASCO 2014 support the clinical efficacy of Myriad's BRACAnalysis CDx and HRD tests in predicting platinum based therapy response for breast cancer patients. In addition, the company is providing an update on key commercial milestones that underscore its commitment to the field of companion diagnostics. Myriad also will present data on the likely utility of its HRD test as a more comprehensive companion diagnostic for DNA damaging agents.

Contact: Ronald Rogers
Myriad Genetics, Inc.

Public Release: 30-May-2014
ASCO 50th Annual Meeting
Radiation for prostate cancer linked to secondary cancers, study finds
Among men treated for prostate cancer, those who received radiation therapy were more likely to develop bladder or rectal cancer, according to a new study from the University of Michigan Comprehensive Cancer Center.
National Institutes of Health

Contact: Nicole Fawcett
University of Michigan Health System

Public Release: 30-May-2014
Nature Biotechnology
New software tool identifies genetic mutations that influence disease risk
Researchers at The University of Texas MD Anderson Cancer Center and other institutions have applied a newly developed software tool to identify genetic mutations that contribute to a person's increased risk for developing common, complex diseases, such as cancer.

Contact: Katrina Burton
University of Texas M. D. Anderson Cancer Center

Public Release: 30-May-2014
ASCO 50th Annual Meeting
Study highlights side effects felt by BRCA mutation carriers after cancer risk-reducing procedure
The majority of women with cancer causing BRCA1 and BRCA2 mutations experience sexual dysfunction, menopausal symptoms, cognitive and stress issues, and poor sleep following prophylactic removal of their Fallopian tubes and ovaries -- a procedure known as risk-reducing salpingo-oophorectomy -- according to results of a new study from the Abramson Cancer Center and the Perelman School of Medicine at the University of Pennsylvania.

Contact: Katie Delach
University of Pennsylvania School of Medicine

Public Release: 30-May-2014
Journal of Clinical Investigation
Moffitt Cancer Center instrumental in new clinical guidelines for cancer-related fatigue
Fatigue is a debilitating problem for cancer patients undergoing treatment; however, it also poses a huge detriment after treatment and can significantly affect quality of life. Approximately 30 percent of cancer patients endure persistent fatigue for several years after treatment, according to an American Society of Clinical Oncology Expert Panel co-chaired by Paul Jacobsen, Ph.D., associate center director of Population Sciences at Moffitt Cancer Center.

Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 30-May-2014
ASCO 50th Annual Meeting
Women with metastatic breast cancer can safely receive bisphosphonates less frequently, without comp
Women with metastatic breast cancer to the bone may be able to receive bisphosphonates, the bone-targeting class of drugs like zoledronic acid, less often after the first year of monthly administration. With that practice change, women may also reduce their risk of serious side effects, according to a study led by researchers at The University of Texas MD Anderson Cancer Center.

Contact: Laura Sussman
University of Texas M. D. Anderson Cancer Center

Public Release: 29-May-2014
BJU International
Circumcision linked to reduced risk of prostate cancer in some men
Circumcision is performed for various reasons, including those that are based on religion, aesthetics, or health. New research indicates that the procedure may help prevent prostate cancer in some men. The findings, which are published in BJU International, add to a growing list of advantages to circumcision.

Contact: Evelyn Martinez

Public Release: 29-May-2014
Journal of the American Society of Nephrology
Reduced kidney function associated with higher risk of renal and urothelial cancer
A key measure of reduced kidney function and chronic kidney disease -- reduced glomerular filtration rate -- is an independent risk factor for renal and urothelial cancer, according to a study published online today in the Journal of the American Society of Nephrology.
National Institutes of Health

Contact: Cyrus Hedayati
Kaiser Permanente

Public Release: 29-May-2014
Journal of American Society of Nephrology
Reduced kidney function associated with higher risk of renal and urothelial cancer
Researchers who investigated the level of kidney function and subsequent cancer risk in more than one million adults have found that reduced glomerular filtration rate -- a key measure of reduced kidney function and chronic kidney disease -- is an independent risk factor for renal and urothelial cancer but not other cancer types.
National Institutes of Health, NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Contact: Linda Aagard
University of Utah Health Sciences

Public Release: 29-May-2014
Cancer Cell
Melanoma of the eye caused by 2 gene mutations
Researchers at the University of California, San Diego School of Medicine have identified a therapeutic target for treating the most common form of eye cancer in adults. They have also, in experiments with mice, been able to slow eye tumor growth with an existing FDA-approved drug.
National Institutes of Health, California Institute for Regenerative Medicine

Contact: Scott LaFee
University of California - San Diego

Public Release: 29-May-2014
How breast cancer 'expresses itself'
Two Tel Aviv University researchers have found that 'gene regulation,' the process that shuts off certain parts of a cell's DNA code or blueprint in healthy breast tissue cells, may also play a critical role in the development of breast cancer. Their research proves a significant link between breast-specific genes and the pathology of cancer.

Contact: George Hunka
American Friends of Tel Aviv University

Public Release: 29-May-2014
ASCO 50th Annual Meeting
Rare skin cancer on palms and soles more likely to come back compared to other melanomas
A rare type of melanoma that disproportionately attacks the palms and soles and under the nails of Asians, African-Americans, and Hispanics, who all generally have darker skins, and is not caused by sun exposure, is almost twice as likely to recur than other similar types of skin cancer, according to results of a study in 244 patients.

Contact: David March
NYU Langone Medical Center / New York University School of Medicine

Public Release: 29-May-2014
New England Journal of Medicine
Mechanisms of ibrutinib resistance identified in chronic lymphocytic leukemia
A new study has discovered how resistance develops in patients taking ibrutinib, a new and highly effective drug for the treatment of chronic lymphocytic leukemia.
NIH/National Cancer Institute

Contact: Amanda Harper
Ohio State University Wexner Medical Center

Public Release: 29-May-2014
Applied Physiology, Nutrition and Metabolism
Diet and exercise in cancer prevention and treatment: Focus of APNM special
This Special Issue titled 'The role of diet, body composition, and physical activity on cancer prevention, treatment, and survivorship' comprises both invited reviews and original papers investigating various themes such as the role of omega-3 fatty acids, amino acids, cancer cachexia, muscle health, exercise training, adiposity and body composition.

Contact: Jenny Ryan
Canadian Science Publishing (NRC Research Press)

Public Release: 28-May-2014
BIO International Convention
Artificial lung the size of a sugar cube
What medications can be used to treat lung cancer, and how effective are they? Until now, drug companies have had to rely on animal testing to find out. But in the future, a new 3-D model lung is set to achieve more precise results and ultimately minimize -- or even completely replace -- animal testing. From June 23-26, researchers will be presenting their new model at the BIO International Convention in San Diego, Calif.

Contact: Dr. Heike Walles

Public Release: 28-May-2014
'Nanodaisies' deliver drug cocktail to cancer cells
Biomedical engineering researchers have developed daisy-shaped, nanoscale structures that are made predominantly of anti-cancer drugs and are capable of introducing a 'cocktail' of multiple drugs into cancer cells.
National Institutes of Health

Contact: Matt Shipman
North Carolina State University

Public Release: 28-May-2014
MRI catches breast cancer early in at-risk survivors of childhood Hodgkin lymphoma
The largest clinical study to evaluate breast cancer screening of female survivors of childhood Hodgkin lymphoma, who are at increased risk because they received chest radiation, shows that magnetic-resonance imaging detected invasive breast tumors at very early stages, when cure rates are expected to be excellent.

Contact: Jane Finlayson
University Health Network

Public Release: 28-May-2014
Annals of Surgical Oncology
NYU researchers pilot educational and behavioral program to reduce lymphedema risk
NYU researchers conducted a pilot study to evaluate a patient-centered educational and behavioral self-care program called The Optimal Lymph Flow. The goals of the program were to promote lymph flow and optimize BMI over a 12-month period after breast cancer surgery. Findings offer initial evidence in support of a shift in the focus of lymphedema care away from treatment and toward proactive risk reduction.
Avon Foundation, NIH/National Cancer Institute

Contact: christopher james
New York University

Public Release: 28-May-2014
Cancer Cell
International collaboration highlights new mechanism explaining how cancer cells spread
UT Southwestern Medical Center cancer researchers have identified a protein critical to the spread of deadly cancer cells and determined how it works, paving the way for potential use in diagnosis and eventually possible therapeutic drugs to halt or slow the spread of cancer.
National Institutes of Health, China Postdoctoral Science Foundation

Contact: Russell Rian
UT Southwestern Medical Center

Public Release: 28-May-2014
Journal of Urology
Study affirms value of epigenetic test for markers of prostate cancer
A multicenter team of researchers report that a commercial test designed to rule out the presence of genetic biomarkers of prostate cancer may be accurate enough to exclude the need for repeat prostate biopsies in many -- if not most -- men.

Contact: Stephanie Desmon
Johns Hopkins Medicine

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