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Public Release: 13-Oct-2014
Cancer Cell
New cancer drug to begin trials in multiple myeloma patients
Scientists at Imperial College London have developed a new cancer drug which they plan to trial in multiple myeloma patients by the end of next year.
Medical Research Council, National Institutes of Health, Cancer Research UK

Contact: Sam Wong
Imperial College London

Public Release: 13-Oct-2014
Nearly 1 in 3 UK lung cancer patients dies within 3 months of diagnosis
Nearly one in three lung cancer patients in the UK dies within three months of diagnosis, despite having visited their family doctor several times beforehand, reveals an analysis of primary care data, published online in the journal Thorax.
Roy Castle Lung Foundation

Contact: Emma Dickinson

Public Release: 13-Oct-2014
Proceedings of the National Academy of Sciences
Greater rates of mitochondrial mutations discovered in children born to older mothers
The discovery of a 'maternal age effect' could be used to predict the accumulation of mitochondrial DNA mutations in maternal egg cells -- and the transmission of these mutations to children. These mutations cause more than 200 diseases and contribute to others such as diabetes, cancer, Parkinson's disease, and Alzheimer's disease.
Penn State University, Pennsylvania Department of Health, Battelle Memorial Institute

Contact: Barbara K. Kennedy
Penn State

Public Release: 13-Oct-2014
Developmental Cell
Sonic Hedgehog protein causes DNA damage and the development child brain tumors
Scientists at the Institut de recherches cliniques de Montreal and the University of Montreal discovered a mechanism that promotes the progression of medulloblastoma, the most common brain tumor found in children.
Canadian Institutes of Health Research, Canadian Cancer Society, Cancer Research Society

Contact: William Raillant-Clark
University of Montreal

Public Release: 13-Oct-2014
Proceedings of the National Academy of Sciences
Discovery of cellular snooze button advances cancer and biofuel research
The discovery of a cellular snooze button has allowed a team of Michigan State University scientists to potentially improve biofuel production and offer insight on the early stages of cancer.

Contact: Layne Cameron
Michigan State University

Public Release: 13-Oct-2014
How metastases develop in the liver
Most tumors are only fatal if the cancer cells spread in the body and form secondary tumors, known as metastases, in other organs, such as the liver. Scientists at Klinikum rechts der Isar of Technische Universität München have now shown that increased amounts of a particular protein in the liver create favorable conditions for the implantation of cancer cells and thus for the formation of metastases. The researchers have already succeeded in preventing these processes in an animal model.

Contact: Vera Siegler
Technische Universitaet Muenchen

Public Release: 13-Oct-2014
JAMA Internal Medicine
Study estimates 14 million smoking-attributable major medical conditions in US
Adults in the United States suffered from approximately 14 million major medical conditions attributable to smoking.

Contact: Jenny Haliski
The JAMA Network Journals

Public Release: 13-Oct-2014
Genome Research
PTPRZ-MET fusion protein: A new target for personalized brain cancer treatment
Researchers at the University of California, San Diego School of Medicine have identified a new fusion protein found in approximately 15 percent of secondary glioblastomas or brain tumors. The finding offers new insights into the cause of this cancer and provides a therapeutic target for personalized oncologic care.
Sontag Foundation, Burroughs Wellcome Foundation, Kimmel Foundation, Doris Duke Foundation, Forbeck Foundation

Contact: Jackie Carr
University of California - San Diego

Public Release: 13-Oct-2014
Treating cancer: UI biologists find gene that could stop tumors in their tracks
UI researchers have found a gene in a soil amoeba that can overcompensate for the specific mutations of a similar gene. In humans, those genetic mutations can often lead to tumor growth. Researchers are now looking for a separate human gene that could overcompensate for mutations in the same way.
NIH/The Developmental Studies Hybridoma Bank

Contact: Brittany Borghi
University of Iowa

Public Release: 13-Oct-2014
Cancer Research
Oral drug reduces formation of precancerous polyps in the colon, UB researchers find
Inflammatory cells in the colon, or polyps, are very common after the age of 50. The average 60-year-old has an estimated 25 percent chance of having polyps. Most polyps are benign, but some will develop into colon cancer. Now, an oral drug has successfully treated chronic, precancerous inflammation in the intestine in an animal study.
National Institutes of Health, Howard Hughes Medical Institute

Contact: Ellen Goldbaum
University at Buffalo

Public Release: 13-Oct-2014
Journal of Clinical Endocrinology and Metabolism
Cushing's syndrome: LCSB researchers characterize a new tumor syndrome
Scientists at the Luxembourg Centre for Systems Biomedicine of the University of Luxembourg have published their findings that mutations in a gene known as 'ARMC5' promote the growth of benign tumors in the adrenal glands and on the meninges: ARMC5 appears to belong to the group of so-called tumor suppressor genes. It is the first time in years that scientists have characterized such a gene.

Contact: Britta Schlüter
University of Luxembourg

Public Release: 13-Oct-2014
Journal of American Chemical Society
Bio-inspired 'nano-cocoons' offer targeted drug delivery against cancer cells
Biomedical engineering researchers have developed a drug delivery system consisting of nanoscale 'cocoons' made of DNA that target cancer cells and trick the cells into absorbing the cocoon before unleashing anticancer drugs.

Contact: Matt Shipman
North Carolina State University

Public Release: 10-Oct-2014
Cancer Epidemiology, Biomarkers & Prevention
Elevated cholesterol and triglycerides may increase the risk for prostate cancer recurrence
Higher levels of total cholesterol and triglycerides, two types of fat, in the blood of men who underwent surgery for prostate cancer, were associated with increased risk for disease recurrence, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
National Institutes of Health

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 10-Oct-2014
Cancer Epidemiology, Biomarkers & Prevention
Hormone loss could be involved in colon cancer
Like diabetes, colon cancer may be caused in part by the loss of one hormone, suggesting hormone replacement therapy could stall cancer formation.

Contact: Edyta Zielinska
Thomas Jefferson University

Public Release: 10-Oct-2014
Physics in Medicine and Biology
New technique enables increasingly accurate PET scan to detect cancer and heart conditions
A novel technique which reduces image degradation caused by respiratory motion during a PET scan was developed in a recent study at the University of Eastern Finland. The new technique is based on bioimpedance measurement and it allows for image reconstruction at a specific phase of the patient's breathing pattern. This, in turn, makes it possible to reduce image degradation caused by motion.

Contact: Tuomas Koivumäki
University of Eastern Finland

Public Release: 10-Oct-2014
Clinical and Translational Gastroenterology
LSU Health tumor registry data find Acadiana colon cancer rates among nation's highest
A special study using data from LSU Health New Orleans School of Public Health's Louisiana Tumor Registry has found that colorectal cancer incidence rates in the Louisiana Acadian parishes are among the highest in the United States. This study appears to be the first to identify a high rate of cancer in a large, regional, US founder population, raising the possibility of a genetic predisposition. Alternatively, an unidentified, robust environmental risk factor may be present.
NIH/National Institute of Cancer, US Centers for Disease Control and Prevention

Contact: Leslie Capo
Louisiana State University Health Sciences Center

Public Release: 10-Oct-2014
An unexpected bonus
The STAT transcription factors are involved in the development of many forms of cancer. STAT3 is frequently activated in tumor cells, so drugs targeting STAT3 could be used in cancer therapy. However, STAT3 is also important in the development of the immune system. Dagmar Gotthardt and colleagues at the Vetmeduni Vienna now show that blocking STAT3 in cells of the immune system actually leads to increased anti-tumor immunity. Anti-STAT3 therapy may thus be highly promising.

Contact: Susanna Kautschitsch
University of Veterinary Medicine -- Vienna

Public Release: 10-Oct-2014
CNIO researchers associate 2 oncogenes with the aggressiveness and incidence of leukemia in mice
Fighting oncogenes Cdk4 and Cdk6 with inhibitors that target both molecules is more effective than inhibiting them individually. These findings could have relevance in the further development of this group of drugs, which are already being tested successfully in breast cancer clinical trials.

Contact: Nuria Noriega
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 9-Oct-2014
New computational approach finds gene that drives aggressive brain cancer
Using an innovative algorithm that analyzes gene regulatory and signaling networks, Columbia University Medical Center researchers have found that loss of a gene called KLHL9 is the driving force behind the most aggressive form of glioblastoma, the most common form of brain cancer.
NIH/National Cancer Institute, National Institutes of Health

Contact: Lucky Tran
Columbia University Medical Center

Public Release: 9-Oct-2014
BMC Medicine
Bowel cancer risk reduced by adopting multiple healthy behaviors
Adoption of a combination of five key healthy behaviors is associated with a reduction in the risk of developing bowel cancer. Researchers from the German Institute of Human Nutrition Potsdam-Rehbruecke quantified the impact of combined multiple healthy lifestyle behaviors on the risk of developing bowel cancer, and found that this impact is stronger in men than in women.

Contact: Shane Canning
BioMed Central

Public Release: 9-Oct-2014
Nature Communications
Nanoparticles get a magnetic handle
Glowing nanoparticles can be manipulated using magnetic fields.

Contact: Andrew Carleen
Massachusetts Institute of Technology

Public Release: 9-Oct-2014
Researchers reveal genomic diversity of individual lung tumors
A study led by scientists at the University of Texas MD Anderson Cancer Center addresses the challenge of what scientists call genomic heterogeneity, the presence of many different variations that drive tumor formation, growth and progression, and likely complicate the choice and potential efficacy of therapy.
Cancer Prevention and Research Institute of Texas, University of Texas, US Department of Defense, Welch Foundation, NIH/National Cancer Institute, National Institutes of Health

Contact: Scott Merville
University of Texas M. D. Anderson Cancer Center

Public Release: 9-Oct-2014
Journal of Molecular Diagnostics
Researchers find RNA molecules in urine and tissue that detect prostate cancer
Researchers at Sanford-Burnham Medical Research Institute have identified a set of RNA molecules that are detectable in tissue samples and urine of prostate cancer patients but not in normal healthy individuals. The study sets the stage for the development of more sensitive and specific noninvasive tests for prostate cancer than those currently available, which could result in fewer unnecessary prostate biopsies with less treatment-related morbidity, according to a new study in The Journal of Molecular Diagnostics.
NIH/National Cancer Institute, International Prostate Cancer Foundation.

Contact: Eileen Leahy
Elsevier Health Sciences

Public Release: 9-Oct-2014
Journal of Clinical Investigation
Unusual skin cancer linked to chronic allergy from metal orthopedic implant
In rare cases, patients with allergies to metals develop persistent skin rashes after metal devices are implanted near the skin. New research suggests these patients may be at increased risk of an unusual and aggressive form of skin cancer.
National Institutes of Health, Howard Hughes Medical Institute, American Skin Association, Dermatology Foundation

Contact: Michael C. Purdy
Washington University School of Medicine

Public Release: 9-Oct-2014
Journal of Biological Chemistry
Advanced X-ray, neutron beam imaging reveal workings of powerful biochemical switch PKA
A University of Utah-led study using X-rays and neutron beams has revealed the inner workings of a master switch that regulates basic cellular functions, but that also, when mutated, contributes to cancer, cardiovascular disease and other deadly disorders.
US Department of Energy, National Institutes of Health

Contact: Phil Sahm
University of Utah Health Sciences

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