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Showing releases 1026-1050 out of 1212.

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Public Release: 5-Mar-2013
Nature Reviews Genetics
Molecular coordination in evolution: A review in 'Nature Reviews Genetics'
Spanish National Cancer Research Centre researchers Alfonso Valencia, Director of the Structural Biology and Biocomputing Programme and David de Juan, jointly with Florencio Pazos, from the Spanish National Centre for Biotechnology, publish a review on the latest computational methods that, based on evolutionary principles, are revolutionizing the field of analysis and prediction of protein structure, function and protein-protein interactions, as well as the short- and long-term expectations for the field.

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 4-Mar-2013
Proceedings of the National Academy of Sciences
Discovery opens door to new drug options for serious diseases
Researchers have discovered how oxidative stress can turn to the dark side a cellular protein that's usually benign, and make it become a powerful, unwanted accomplice in neuronal death. This finding could ultimately lead to new therapeutic approaches to many of the world's debilitating or fatal diseases.
National Institutes of Health

Contact: Joseph Beckman
joe.beckman@oregonstate.edu
541-737-8867
Oregon State University

Public Release: 4-Mar-2013
Annals of Internal Medicine
Colon cancer screening doubles with new e-health record use
Researchers used electronic health records to identify Group Health patients who weren't screened regularly for cancer of the colon and rectum -- and to encourage them to be screened. This centralized, automated approach doubled these patients' rates of on-time screening -- and saved health costs -- over two years. The Mar. 5 Annals of Internal Medicine published the randomized controlled trial.
NIH/National Cancer Institute

Contact: Rebecca Hughes
hughes.r@ghc.org
206-287-2055
Group Health Research Institute

Public Release: 4-Mar-2013
Annals of Internal Medicine
Annals of Internal Medicine tip sheet for March 5, 2013
Below is information about articles being published in the March 5 issue of Annals of Internal Medicine.

Contact: Megan Hanks
mhanks@acponline.org
215-351-2656
American College of Physicians

Public Release: 4-Mar-2013
Lancet
New data show countries around the world grappling with changing health challenges
Alzheimer's disease is the fastest growing threat to health in the US. HIV/AIDS and alcohol are severely eroding the health of Russians. Violence is claiming the lives of young men in large swaths of Latin America. Despite health gains in sub-Saharan Africa, infectious diseases still cause hundreds of thousands of child deaths. These findings will be announced on March 5 at the Bill & Melinda Gates Foundation in Seattle, by IHME Director Dr. Christopher Murray and Bill Gates.
Bill & Melinda Gates Foundation

Contact: Rhonda Stewart
stewartr@uw.edu
206-861-6684
Institute for Health Metrics and Evaluation

Public Release: 4-Mar-2013
PLOS ONE
The right dose for oncology
EPFL researchers develop a tool for oncologists using the electrical signature of cancer cells to get just the right treatment dosage for each patient.

Contact: Lionel Pousaz
lionel.pousaz@epfl.ch
41-795-597-161
Ecole Polytechnique Fédérale de Lausanne

Public Release: 4-Mar-2013
Health & Place
Neighborhood poverty and health insurance figure in late-stage diagnosis of breast cancer

A team of scientists was assembled by the North American Association of Central Cancer Registries to examine breast cancer stage at diagnosis among 161,619 women aged 40 years and older diagnosed in ten participating US states. The team's findings are reported in the current issue of the journal Health & Place.


Komen for the Cure and North American Association of Central Cancer Registries

Contact: Betsy A. Kohler
bkohler@naaccr.org
217-698-0800 x2
North American Association of Central Cancer Registries, Inc.

Public Release: 4-Mar-2013
Scientific Reports
Study uncovers enzyme's double life, critical role in cancer blood supply
Studied for decades for their essential role in making proteins within cells, several amino acids known as tRNA synthetases were recently found to have an unexpected -- and critical -- additional role in cancer metastasis. University of Vermont researchers determined that threonyl tRNA synthetase leads a "double life," regulating a pathway used by invasive cancers to induce the formation of new blood vessels, and a new food supply to sustain their growth.
National Institutes of Health

Contact: Jennifer Nachbur
jennifer.nachbur@uvm.edu
802-656-7875
University of Vermont

Public Release: 4-Mar-2013
Proceedings of the National Academy of Sciences
Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury
Oxidative stress turns a protein that normally protects healthy cells into their executioner, according to a study released today in the Proceedings of the National Academy of Sciences journal.
National Institutes of Health, Burke Medical Research Institute, ALS Association

Contact: Wendy Sarubbi
wendy.sarubbi@ucf.edu
407-266-1418
University of Central Florida

Public Release: 4-Mar-2013
Nature Genetics
First evidence that obesity gene is risk factor for melanoma
The gene most strongly linked to obesity and over eating may also increase the risk of malignant melanoma -- the most deadly skin cancer, according to Cancer Research UK scientists at the University of Leeds.
Cancer Research UK

Contact: Rachel Barson
r.barson@leeds.ac.uk
01-133-432-060
University of Leeds

Public Release: 4-Mar-2013
Journal of Clinical Oncology
Prospective study finds many children with retinoblastoma can safely forego adjuvant chemotherapy
The summary of a study being published online Mar. 4, 2013 in the Journal of Clinical Oncology reports that in certain children with retinoblastoma, adjuvant chemotherapy can be avoided without risking worsening the disease or relapsing.

Contact: Nicole Racadag
nicole.racadag@asco.org
571-483-1354
American Society of Clinical Oncology

Public Release: 3-Mar-2013
Nature Medicine
Cancer vaccines self-sabotage, channel immune attack to injection site
UT MD Anderson scientists have found that many therapeutic cancer vaccines fail because they attract more T cells to the injection site than to the tumors. Replacing the adjuvant IFA with a saline solution reversed that, destroying tumors and minimizing injection site reaction.
NIH/National Cancer Institute, Melanoma Research Alliance

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center

Public Release: 3-Mar-2013
Nature Immunology
Researchers discover how to shutdown cancer's powerful master protein
The powerful master regulatory transcription factor called Bcl6 is key to the survival of a majority of aggressive lymphomas, which arise from the B-cells of the immune system. The protein has long been considered too complex to target with a drug since it is also crucial to the healthy functioning of many immune cells in the body, not just B cells gone bad.
NIH/National Cancer Institute, Burroughs Wellcome Foundation, Chemotherapy Foundation

Contact: Lauren Woods
Law2014@med.cornell.edu
646-317-7401
Weill Cornell Medical College

Public Release: 3-Mar-2013
Nature Biotechnology
International consortium builds 'Google Map' of human metabolism
Building on earlier pioneering work by researchers at the University of California, San Diego, an international consortium of university researchers has produced the most comprehensive virtual reconstruction of human metabolism to date. Scientists could use the model, known as Recon 2, to identify causes of and new treatments for diseases like cancer, diabetes and even psychiatric and neurodegenerative disorders.

Contact: Catherine Hockmuth
chockmuth@ucsd.edu
858-822-1359
University of California - San Diego

Public Release: 3-Mar-2013
Nature Immunology
Gene discovery reveals importance of eating your greens
Eating your greens may be even more important that previously thought, with the discovery that an immune cell population essential for intestinal health could be controlled by leafy greens in your diet. The immune cells, named innate lymphoid cells, are found in the lining of the digestive system and protect the body from 'bad' bacteria in the intestine. They are also believed to play an important role in controlling food allergies, inflammatory diseases and obesity, and may even prevent the development of bowel cancers.
National Health and Medical Research Council, Sylvia and Charles Viertel Foundation, Howard Hughes Medical Institute, Victorian Government

Contact: Liz Williams
williams@wehi.edu.au
61-405-279-095
Walter and Eliza Hall Institute

Public Release: 1-Mar-2013
Journal of Clinical Investigation
Tumors deliberately create conditions that inhibit body's best immune response
New research in the Journal of Clinical Investigation reveals that tumors in melanoma patients deliberately create conditions that knock out the body's 'premier' immune defense and instead attract a weaker immune response unable to kill off the tumor's cancerous cells.

Contact: Marianne Slegers
marianne.slegers@kcl.ac.uk
44-207-848-3840
King's College London

Public Release: 1-Mar-2013
Journal of Clinical Investigation
JCI early table of contents for Mar. 1, 2013
The following release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Mar. 1, 2013, in the JCI: Coordinating adaptive responses to cardiac stress; A nanogel-based therapy for the treatment of lupus; and many more.

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 1-Mar-2013
Cancer
'Where you're treated matters' in terms of cancer survival
A study of older patients with advanced head and neck cancers has found that where they were treated significantly influenced their survival.
National Institutes of Health

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center

Public Release: 1-Mar-2013
Journal of Adolescent Health
Cancer doesn't change young girls' desire to have children, Moffitt Cancer Center study shows
Researchers at Moffitt Cancer Center and colleagues have found that healthy adolescent females have predetermined expectations for becoming parents in the future, but have concerns about fertility and childbearing should they develop a life-threatening illness, such as cancer.

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 1-Mar-2013
Journal of Immunology
Mechanisms regulating inflammation associated with type 2 diabetes, cancer identified
A study led by researchers at Boston University School of Medicine has identified epigenetic mechanisms that connect a variety of diseases associated with inflammation.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases

Contact: Jenny Eriksen Leary
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center

Public Release: 1-Mar-2013
Gastrointestinal Endoscopy
Study confirms safety of colonoscopy
Colon Cancer Awareness Month is about encouraging more people to get tested for colorectal cancer. Colonoscopy is the most reliable screening test. A current study from the German Cancer Research Center confirms that, contrary to what some critics say, it is also safe. If more people made use of screening tests, about half of all new colorectal cancer cases and deaths from this cancer could be avoided in Germany every year.

Contact: Sibylle Kohlstädt
s.kohlstaedt@dkfz.de
Helmholtz Association

Public Release: 1-Mar-2013
Nature Chemical Biology
New chemical probe provides tool to investigate role of malignant brain tumor domains
UNC researchers announce the discovery of a chemical probe that can be used to investigate the L3MBTL3 methyl-lysine reader domain. The probe, named UNC1215, will provide researchers with a powerful tool to investigate the function of malignant brain tumor domain proteins in biology and disease.
National Institutes of Health, University Cancer Research Fund

Contact: William Davis
william_davis@med.unc.edu
919-962-3405
University of North Carolina Health Care

Public Release: 28-Feb-2013
Particle & Particle Systems Characterization
Trackable drug-filled nanoparticles -- a potential weapon against cancer
Tiny particles filled with a drug could be a new tool for treating cancer in the future. A new study published by Swedish scientists in Particle & Particle Systems Characterization shows how such nanoparticles can be combined to secure the effective delivery of cancer drugs to tumor cells -- and how they can be given properties to make them visible in MR scanners and thus be rendered trackable.
The Swedish Research Council and others.

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet

Public Release: 28-Feb-2013
Journal of the National Cancer Institute
Nearly 1 in 4 women newly diagnosed with breast cancer
A study by researchers found that nearly one in four women (23 percent) newly diagnosed with breast cancer reported symptoms consistent with post-traumatic stress disorder shortly after diagnosis, with increased risk among black and Asian women.
NIH/National Cancer Institute, US Department of Defense

Contact: Stephanie Berger
sb2247@columbia.edu
212-305-4372
Columbia University's Mailman School of Public Health

Public Release: 28-Feb-2013
Cancer Cell
Groundbreaking UK study shows key enzyme missing from aggressive form of breast cancer
A groundbreaking new study led by the University of Kentucky Markey Cancer Center's Dr. Peter Zhou found that triple-negative breast cancer cells are missing a key enzyme that other cancer cells contain -- providing insight into potential therapeutic targets to treat the aggressive cancer. Zhou's study is unique in that his lab is the only one in the country to specifically study the metabolic process of triple-negative breast cancer cells.

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky

Showing releases 1026-1050 out of 1212.

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