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Showing releases 1026-1050 out of 1124. << < 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 > >>
Public Release: 19-Jun-2012
 BiochemistryMoving 3D computer model of key human protein is powerful new tool in fight against cancer Researchers long have relied on static images of human P-glycoprotein, a major contributor to chemotherapy failure in recurring cancers. Now biochemist John Wise, Southern Methodist University, Dallas, has deduced its structure and built a moving 3D computer model. Wise is pairing this powerful new tool with SMU's high-performance supercomputer in search of a potent inhibitor. Virtual screening of more than eight million compounds has resulted in promising leads that may help stop chemotherapy failures. 
National Institutes of Health, NIH/National Institute of General Medical Sciences
Contact: Margaret Allen
Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and ChallengesAdding erlotinib to bevacizumab/chemoradiotherapy regimen for pancreatic cancer safe, tolerable The addition of high doses of erlotinib to the treatment regimen of bevacizumab and capecitabine with radiotherapy seems to benefit patients with locally advanced pancreatic cancer, according to results of a phase I study presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held June 18-21.
Genentech
Contact: Jeremy Moore
Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and ChallengesBiomarker panel to screen for pancreatic cancer may be possible The development of a highly accurate, blood-based pancreatic adenocarcinoma screen that would be accurate enough to test the general population for this deadly disease may not be far out of reach, according to data presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held June 18-21, 2012. Contact: Jeremy Moore
Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and ChallengesSun exposure and sun-sensitive skin type decreased risk for pancreatic cancer High levels of ultraviolet radiation at an individual's birth location, sun-sensitive skin type and a history of skin cancer each decreased risk for pancreatic cancer, according to study results presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held June 18-21. Contact: Jeremy Moore
Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and ChallengesInhibiting Hedgehog signaling pathway may improve pancreatic cancer treatment Combining a new targeted therapy with standard chemotherapy may help defeat pancreatic cancer, according to results presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held June 18-21. Contact: Jeremy Moore
Public Release: 19-Jun-2012
Cancer DiscoveryAbnormal gene product associated with prostate cancer generated by unusual mechanism Researchers have identified a potential new pathway in prostate cancer cells by which cancer-driving gene products can be generated, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.
Stand Up To Cancer
Contact: Jeremy Moore
Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and ChallengesRLIP76 contributes to pancreatic cancer cell resistance to chemotherapy and radiation Researchers at the City of Hope Comprehensive Cancer Center have not only identified a protein that allows pancreatic cancer cells to resist therapy but also developed a way to block it, according to results presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held June 18-21. Contact: Jeremy Moore
Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and ChallengesMetformin treatment caused cancer stem cell death in pancreatic cancer cell lines Results of some preclinical trials have shown that low doses of the antidiabetic drug metformin may effectively destroy cancer stem cells, a group of cells that are considered to be responsible for tumor initiation and, because they are resistant to standard chemotherapies, tumor relapse. Contact: Jeremy Moore
Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and ChallengesNerve growth factors elevated in pancreatic cancer model Severe pain is a major symptom of pancreatic cancer. The results of a new study show that four different factors involved in the growth and maintenance of nerves are elevated in a mouse model of pancreatic cancer. This is a step forward in understanding the relationship between the development of pain and the progression of pancreatic cancer.
NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute of Diabetes and Digestive and Kidney Diseases, Shirley Hobbs Martin Memorial Fund
Contact: Jeremy Moore
Public Release: 19-Jun-2012
International Journal of CancerDoes night work put women's health at risk? The results of a study carried out by the researchers of the Inserm unit 1018 and published in the International Journal of Cancer show that the risk of developing breast cancer is higher among women who have worked at night. The study, carried out in France and named the CECILE study, compared the careers of 1,200 women who had developed breast cancer between 2005 and 2008 with the careers of 1,300 other women. Contact: Press Inserm
Public Release: 19-Jun-2012
PLOS Genetics23andMe contributes to genetic discoveries related to male pattern baldness 23andMe has contributed to the finding of six novel genetic associations for early onset male pattern baldness in a genome-wide association study now published online in the journal PLoS Genetics. The study found that even after accounting for this shared association, men were still more likely to report both male pattern baldness and Parkinson's disease than would be expected by chance. This suggests that there may be additional shared genetic or environmental risk factors that predispose towards both conditions.
23andMe
Contact: Jane E. Rubinstein
Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and ChallengesGenetic marker in vitamin D receptor gene associated with increased pancreatic cancer survival Pancreatic cancer patients with a genetic marker linked to increased expression of the receptor for vitamin D have higher rates of overall survival, according to findings presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held June 18-21. Contact: Jeremy Moore
Public Release: 19-Jun-2012
Journal of Cancer SurvivorshipLong-term cancer survivors struggle to keep regular work hours Long-term cancer survivors take sick leave more often than their disease-free colleagues, suggesting that they struggle at work despite their ability to work five years after diagnosis. These findings by Steffen Torp, from Vestfold University College in Norway, and colleagues is published online in Springer's Journal of Cancer Survivorship.
Norwegian Cancer Society
Contact: Joan Robinson
Public Release: 19-Jun-2012
BloodInhibitors of shuttle molecule show promise in acute leukemia A novel family of experimental agents that blocks a molecule from shuttling proteins out of the cell nucleus might offer a new treatment for people with acute leukemia. The agents, called KPT-SINEs (selective inhibitors of nuclear export), target a transport protein called CRM1. The study shows that these agents inhibit leukemia-cell proliferation, arrest cell division, and induce cell death and differentiation. In an animal model, KPT-SINEs extended survival by 46 percent.
NIH/National Cancer Institute, Pelotonia Fellowship award
Contact: Darrell E. Ward
Public Release: 19-Jun-2012
PLOS ONEA new indicator for breast cancer relapse identified Researchers at the IMIM have proven that the absence of the 14-3-3 protein sigma in breast cancer cells is directly associated with these cells' capacity to activate the signaling of a protein complex called NF-kB, which is related to tumor progression. The activation of NF-kB in tumors was also identified as the best indicator for relapse in breast cancer patients, compared to other parameters currently used, such as the presence of affected ganglions or the tumor's size and degree. Contact: Marta Calsina
Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and ChallengesA combination of TH-302 and radiation reduced human pancreatic tumor growth in hypoxic xenografts A combination of the prodrug TH-302 and radiation may provide an effective treatment strategy for pancreatic cancer, according to preclinical results presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held June 18-21. Contact: Jeremy Moore
Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and ChallengesLeukemia inhibitory factor may be a promising target against pancreatic cancer Pancreatic cancer is one of the deadliest forms of cancer, defying most treatments. Its ability to evade therapy may be attributable to the presence of cancer stem cells, a subset of cancer cells present in pancreatic tumors that drive tumor growth by generating bulk tumor cells. Cancer stem cells are notorious for their ability to resist traditional chemotherapies. Contact: Jeremy Moore
Public Release: 18-Jun-2012
Journal of Clinical InvestigationJCI early table of contents for June 18, 2012 This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, June 18, 2012, in the JCI: "Combating fungal eye infections"; "Molecular effects of social isolation on neurotransmission"; "Disrupted adenosine signaling contributes to schizophrenia"; "Imaging immune cell recruitment into the beating heart"; and more. Contact: Sarah Jackson
Public Release: 18-Jun-2012
Annals of Internal MedicineAnnals of Internal Medicine tip sheet for June 19, 2012, online issue This release contains information about articles being published in the June 19 issue of Annals of Internal Medicine. Contact: Abbey Anderson
Public Release: 18-Jun-2012
Archives of Otolaryngology - Head & Neck SurgeryStudy examines chronic inflammation in oral cavity and HPV status of head and neck cancers Among patients with head and neck squamous cell carcinomas, a history of chronic inflammation in the mouth (periodontitis, i.e. gum disease) may be associated with an increased risk of tumors positive for human papillomavirus, according to a report published Online First by Archives of Otolaryngology – Head & Neck Surgery, a JAMA Network publication. Contact: Sara Saldi
Public Release: 18-Jun-2012
Genome ResearchBioinformatics experts at the CNIO explore additional coding potential hidden in the human genome Sequencing the human genome was just the first step. The next challenge is of the kind that makes history: To decode the genome, and understand how the information needed to construct a human being can be packaged into a single molecule. And there are a lot more than loose ends in the way of a solution. A group of bioinformatics experts at the Spanish National Cancer Research Centre in Madrid have published findings which point to still unexplored coding potential within the genome. Contact: Juan J. Gomez
Public Release: 18-Jun-2012
Molecular CellUCLA scientists discover how key enzyme involved in aging, cancer assembles UCLA biochemists have mapped the structure of a key protein-RNA complex that is required for the assembly of telomerase, an enzyme important for both cancer and aging. Contact: Stuart Wolpert
Public Release: 18-Jun-2012
American Journal of HematologyPediatric regime of chemotherapy proves more effective for young adults Dr. Ron Ram of Tel Aviv University has determined that a pediatric chemotherapy regime improves the chances of young adults with leukemia for long-term survival and decreases their mortality rate. And the need for a bone marrow transplant, a common treatment for young adults with ALL, can be avoided as well. Contact: George Hunka
Public Release: 18-Jun-2012
Model Organisms to Human Biology: Cancer GeneticsFish shed light on human melanoma Zebrafish, a transparent member of the minnow family, are providing insight into human melanoma – a form of skin cancer – that may lead to new or repurposed drug treatments, for skin and other cancers. This will be reported by researchers from the Weill Cornell Medical College in New York City at the Genetics Society of America's "Model Organisms to Human Biology: Cancer Genetics" Meeting, June 17-20, 2012, in Washington, D.C at the Omni Shoreham Hotel. Contact: Phyllis Edelman
Public Release: 15-Jun-2012
Genes & DevelopmentScientists discover mechanism that promotes lung cancer growth and survival A multi-institutional research study has uncovered a new mechanism that may lead to unique treatments for lung cancer, one of the leading causes of death worldwide. Contact: John Wallace
Showing releases 1026-1050 out of 1124. << < 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 > >>
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