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Showing releases 1026-1050 out of 1197. << < 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 > >>
Public Release: 13-Dec-2012
 American Journal of Human GeneticsCleveland Clinic researcher identifies 2 new genetic mutations associated with Cowden syndrome Cleveland Clinic researchers from the Lerner Research Institute have uncovered two new genes associated with Cowden syndrome according to a new study, published today in the online version of the American Journal of Human Genetics. Contact: Laura Ambro
Public Release: 13-Dec-2012
Journal of Occupational Medicine and ToxicologyLarge study identifies risk factors for multiple myeloma New research published in Biomed Central's open access journal Journal of Occupational Medicine and Toxicology provides a large (from 22 centers across Europe), matched control study into lifetime risk of multiple myeloma. They find that risk of Multiple myeloma is related to farm work, printing and cleaning. But although exposure to pesticides seemed to be a risk, exposure to organic solvents was not. Contact: Hilary Glover
Public Release: 13-Dec-2012
EMBO Molecular MedicineCancer stem cells isolated from kidney tumors Scientists have isolated cancer stem cells that lead to the growth of Wilms' tumors, a type of cancer typically found in the kidneys of young children. The researchers have used these cancer stem cells to test a new therapeutic approach that one day might be used to treat some of the more aggressive types of this disease. The results are published online in EMBO Molecular Medicine. Contact: Barry Whyte
Public Release: 13-Dec-2012
Cancer ResearchUAlberta medical researchers discover new potential chemotherapy Medical researchers at the University of Alberta have discovered that knocking out a particular "partner" gene is the Achilles' heel of some cancers. 
Canadian Institutes of Health Research
Contact: Raquel Maurier
Public Release: 13-Dec-2012
Science Translational Medicine'Two-faced' cells discovered in colon cancer A "two-faced" group of cells at work in human colon cancer can either suppress or promote tumor growth. These cells are a subset of T-regulatory (Treg) cells, known to suppress immune responses in healthy people. The discovery of Treg diversity in cancer and its role in control of cancer inflammation may lead to new approaches for therapeutics. Contact: Marla Paul
Public Release: 13-Dec-2012
Menopause: The Journal of The North American Menopause SocietyNew hormone therapy shows promise for menopausal symptoms in animal model Investigators at Wake Forest Baptist Medical Center have concluded research on a new postmenopausal hormone therapy that shows promise as an effective treatment for menopausal symptoms and the prevention of osteoporosis without increasing the risk for heart disease or breast cancer.
Pfizer
Contact: Bonnie Davis
Public Release: 13-Dec-2012
Cancer DiscoveryNew screening approach identified potential drug combos for difficult-to-treat melanomas A novel approach to identifying potential anticancer drug combinations revealed that pairing cholesterol-reducing drugs called statins with cyclin-dependent kinase inhibitors might provide an effective approach to treating intractable melanomas driven by mutations in the NRAS and KRAS gene. Contact: Jeremy Moore
Public Release: 13-Dec-2012
ScienceResearchers find new culprit in castration-resistant prostate cancer Scientists at Dana-Farber Cancer Institute have discovered a molecular switch that enables advanced prostate cancers to spread without stimulation by male hormones, which normally are needed to spur the cancer's growth. They say that identifying the previously unknown protein function could serve as a treatment target for prostate cancers that are no longer controlled by hormone-blocking drugs.
Prostate Cancer Foundation, U.S. Department of Defense, National Cancer Institute, NIH
Contact: Bill Schaller
Public Release: 13-Dec-2012
ScienceCancer scientists identify a new layer of complexity within human colon cancer Cancer scientists led by Dr. John Dick at the Princess Margaret Cancer Centre have found a way to follow single tumor cells and observe their growth over time. The team discovered that biological factors and cell behavior -- not only genes -- drive tumor growth, contributing to therapy failure and relapse. Contact: Jane Finlayson
Public Release: 13-Dec-2012
European UrologyNew technique for minimally invasive robotic kidney cancer surgery Urologists at Henry Ford Hospital have developed a new technique that could make minimally invasive robotic partial nephrectomy procedures the norm, rather than the exception for kidney cancer patients. The technique spares the kidney, eliminates long hospital stays and provides better outcomes by giving the surgeon more time to perform the procedure. Contact: Dwight Angell
Public Release: 13-Dec-2012
Journal of the National Cancer InstituteDespite hype, costly prostate cancer treatment offers little relief from side effects Prostate cancer patients receiving the costly treatment known as proton radiotherapy experienced minimal relief from side effects such as incontinence and erectile dysfunction, compared to patients undergoing a standard radiation treatment called intensity modulated radiotherapy, Yale School of Medicine researchers report in the Journal of the National Cancer Institute.
NIH/National Cancer Institute, National Institutes of Health, NIH/National Center for Research Resources, NIH/National Center for Advancing Translational Sciences
Contact: Karen N. Peart
Public Release: 13-Dec-2012
Cancer CellCancer study overturns current thinking about gene activation A new Australian study led by Professor Susan Clark from Sydney's Garvan Institute of Medical Research shows that large regions of the genome -- amounting to roughly 2 percent -- are epigenetically activated in prostate cancer. Regions activated contain many prostate cancer-specific genes, including PSA (prostate specific antigen) and PCA3, the most common prostate cancer markers. Until now, these genes were not known to be regulated epigenetically.
Garvan Institute of Medical Research
Contact: Iris Hui
Public Release: 13-Dec-2012
Proceedings of the National Academy of SciencesStudy sheds light on how cells transport materials along crowded intercellular 'highways' A network of "highways" called microtubules move bio-molecular cargo around inside cells to keep their machinery humming. A new paper published online in the Proceedings of the National Academy of Sciences sheds new light on how cells manage to keep traffic flowing smoothly along this busy transportation network that is vital to the survival of cells and whose failure can lead to a variety of diseases, including Alzheimer's and cancer. Contact: Michael Dorsey
Public Release: 12-Dec-2012
Journal of Clinical OncologyOlder and younger chronic leukemia patients may need different therapy Age is usually not considered when determining treatment for people with chronic lymphocytic leukemia (CLL), but a new study indicates that older patients with CLL may require different therapy than younger patients. The findings highlight the importance of enrolling older patients on CLL trials and of developing trials that specifically target older patients.
NIH/National Cancer Institute, Leukemia and Lymphoma Society, Harry Mangurian Foundation
Contact: Darrell E. Ward
Public Release: 12-Dec-2012
The Journal of Molecular DiagnosticsNovel test identifies patients most likely to benefit from ALK inhibition therapy Researchers have now developed and tested a promising new method for screening anaplastic lymphoma kinase fusions in non-small cell lung carcinoma. This new diagnostic assay offers a cost-effective and easy-to-perform alternative to existing tests. Contact: David Sampson
Public Release: 12-Dec-2012
NatureStudy paves way to design drugs aimed at multiple protein targets at once Pharmaceutical chemists had suggested that the objective of a drug hitting multiple targets simultaneously is impossible and unlikely to succeed. This study shows how to efficiently and effectively make designer drugs that can do that.
National Institutes of Health
Contact: Les Lang
Public Release: 12-Dec-2012
American Journal of PathologyPreviously unknown mechanism identified in oncogene-induced senescence Cell aging, or cellular senescence, has an important role in the natural physiological response to tumor development. Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced senescence could play a key role in future cancer therapy. Researchers have now identified a previously unknown mechanism in the regulation of OIS. Contact: David Sampson
Public Release: 12-Dec-2012
Journal of the Americal Chemical SocietyA second ascent of chemistry's Mt. Everest In science's equivalent of ascending Mt. Everest, researchers are reporting success in one of the most difficult challenges in synthetic chemistry -- a field in which scientists reproduce natural and other substances from jars of chemicals in a lab. The feat, reported in the Journal of the American Chemical Society, involved synthesis of a rare substance with promising in vitro anti-cancer effects found naturally in tiny amounts in a Chinese medicinal herb. Contact: Michael Bernstein
Public Release: 12-Dec-2012
New England Journal of MedicinePre-transplant umbilical cord blood expansion speeds establishment of new blood supply in patients Donated umbilical cord blood establishes a new blood supply in patients more quickly after transplantation when it is first expanded in the lab on a bed of cells that mimics conditions in the bone marrow, researchers report in the Dec. 13 edition of the New England Journal of Medicine. Contact: Scott Merville
Public Release: 12-Dec-2012
Journal of Biological ChemistryProtein strongest just before death Researchers at Michigan State University have discovered a protein that does its best work with one foot in the grave.
National Institutes of Health
Contact: Layne Cameron
Public Release: 12-Dec-2012
LeukemiaSingapore scientists identify new biomarker for cancer in bone marrow Singapore scientists have identified FAIM, a molecule that typically prevents cell death, as a potential biomarker to identify an incurable form of cancer in the bone marrow. Patients with this form of cancer usually do not get cured with current standard treatments such as chemotherapy and stem cell transplantation, with an average survival of only about four years.
Agency for Science, Technology & Research (A*STAR)
Contact: Vithya Selvam
Public Release: 12-Dec-2012
Journal of Biological ChemistryMicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer A University of Colorado Cancer Center study published in the December issue of the Journal of Biological Chemistry shows that in medulloblastoma, a malignant brain tumor of children, microRNA-218 is especially low. The article also shows that adding microRNA-218 to neural stem cells engineered to develop medulloblastoma decreases the development of the cancer.
National Institutes of Health
Contact: Garth Sundem
Public Release: 12-Dec-2012
Breast Cancer Research and TreatmentDelaying childbirth may reduce risk of an aggressive form of breast cancer Younger women who wait at least 15 years after their first menstrual period to give birth to their first child may reduce their risk of an aggressive form of breast cancer by up to 60 percent, according to a Fred Hutchinson Cancer Research Center study.
NIH/National Cancer Institute, US Department of Defense Breast Cancer Research Program
Contact: Kristen Woodward
Public Release: 12-Dec-2012
Journal of the National Cancer InstitutePatients with family history of colorectal cancer may be at risk for aggressive form of the disease When people with a family history of colorectal cancer develop the disease, their tumors often carry a molecular sign that the cancer could be life-threatening, report Dana-Farber Cancer Institute scientists. The finding suggests it may be possible to identify colorectal cancer patients who should receive more aggressive therapies and whose relatives may be at increased risk for the aggressive form of the disease.
National Institutes of Health, Bennett Family Fund for Targeted Therapies Research, National Colorectal Cancer Research Alliance
Contact: Bill Schaller
Public Release: 12-Dec-2012
Emerging Infectious DiseasesEmerging virus in raccoons may provide cancer clues Rare brain tumors emerging among raccoons in Northern California and Oregon may be linked to a previously unidentified virus discovered by a team of researchers, led by scientists from the University of California, Davis.
Bernice Barbour Foundation, University of California, Davis Center for Companion Animal Health, Meadowview Foundation
Contact: Kat Kerlin
Showing releases 1026-1050 out of 1197. << < 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 > >>
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