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Showing releases 1026-1050 out of 1272.

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Public Release: 8-Oct-2014
JAMA Psychiatry
Study looks at cardiometabolic risk, schizophrenia and antipsychotic treatment
The duration of psychiatric illness and treatment for patients after first-episode schizophrenia spectrum disorders appears to be associated with being fatter and having other cardiometabolic abnormalities.

Contact: Michelle Pinto
The JAMA Network Journals

Public Release: 8-Oct-2014
New England Journal of Medicine
Patient's dramatic response and resistance to cancer drug traced to unsuspected mutations
Patients with lethal thyroid cancer experienced response for 18 months on clinical trial of everolimus. Sequencing of the tumor before and after trials yielded information on why tumor responded to and eventually resisted treatment, identifying mutations that may help guide treatment of patients with cancers with similar mutations.
Next Generation Fund at the Broad Institute, Novartis Pharmaceuticals, Starr Cancer Consortium, NIH/National Cancer Institute

Contact: Teresa Herbert
Dana-Farber Cancer Institute

Public Release: 8-Oct-2014
EMBO Reports
Fruit flies reveal features of human intestinal cancer
Researchers in Spain have determined how a transcription factor known as Mirror regulates tumor-like growth in the intestines of fruit flies. The scientists believe a related system may be at work in humans during the progression of colorectal cancer due to the observation of similar genes and genetic interactions in cultured colorectal cancer cells. The results are reported in the journal EMBO Reports.

Contact: Barry Whyte

Public Release: 8-Oct-2014
Breast Cancer Research
Circulating tumor cells provide genomic snapshot of breast cancer
Tumor cells isolated from the blood of patients with triple negative breast cancer reveal similar cancer-driving mutations as those detected from standard biopsy, suggesting that circulating cells could one day replace tissue biopsies.

Contact: Edyta Zielinska
Thomas Jefferson University

Public Release: 7-Oct-2014
Plastic and Reconstructive Surgery -- Global Open
Equation helps assess blood flow to flaps for breast reconstruction
For women undergoing breast reconstruction using the advanced 'DIEP' technique, a simple formula can reliably tell whether there will be sufficient blood flow to nourish the DIEP flap, reports a paper in Plastic and Reconstructive Surgery -- Global Open, the official open-access medical journal of the American Society of Plastic Surgeons.

Contact: Connie Hughes
Wolters Kluwer Health

Public Release: 7-Oct-2014
Testosterone promotes prostate cancer in rats
A researcher who found that testosterone raised the risk of prostate tumors and exacerbated the effects of carcinogenic chemical exposure in rats is urging caution in prescribing testosterone therapy to men who have not been diagnosed with hypogonadism, according to a new study published in the Endocrine Society's journal Endocrinology.

Contact: Jenni Glenn Gingery
The Endocrine Society

Public Release: 7-Oct-2014
Proceedings of the National Academy of Sciences
The 'cyberwar' against cancer gets a boost from intelligent nanocarriers
Cancer possesses special traits for cooperative behavior and uses intricate communication to distribute tasks, share resources, and make decisions. New Tel Aviv University research now offers additional insight into the lethal interaction between cancer cells and the immune system's communications network.

Contact: George Hunka
American Friends of Tel Aviv University

Public Release: 7-Oct-2014
Cell Metabolism
Live and let-7: MicroRNA plays surprising role in cell survival
Researchers at the University of California, San Diego School of Medicine have identified a microRNA molecule as a surprisingly crucial player in managing cell survival and growth. The findings, published in the Oct. 7 issue of Cell Metabolism, underscore the emerging recognition that non-coding RNAs -- small molecules that are not translated into working proteins -- help regulate basic cellular processes and may be key to developing new drugs and therapies.
National Institutes of Health, Portuguese Foundation for Science and Technology

Contact: Scott LaFee
University of California - San Diego

Public Release: 7-Oct-2014
Researchers find link between tobacco use and viral infection that causes oral cancers
Johns Hopkins scientists have shown a strong association between tobacco use or exposure and infection with oral human papillomavirus type 16, the sexually transmitted virus responsible for mouth and throat cancers worldwide. The numbers of such cancers have increased 225 percent in the United States over the past two decades.
NIH/National Institute of Dental and Craniofacial Research, Milton J. Dance Jr. Head and Neck Center at Greater Baltimore Medical Center, Merck

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 7-Oct-2014
Royal Society of Chemistry
New 'lab-on-a-chip' could revolutionize early diagnosis of cancer
Yong Zeng and colleagues from the University of Kansas Medical Center and KU Cancer Center have published a breakthrough paper in the Royal Society of Chemistry journal describing their invention of a miniaturized biomedical testing device for exosomes.
National Cancer Institute

Contact: Brendan M. Lynch
University of Kansas

Public Release: 7-Oct-2014
Cell Metabolism
Researchers identify 'Achilles heel' in metabolic pathway that could lead to new cancer treatment
Researchers at University of Texas Southwestern Medical Center have found an 'Achilles heel' in a metabolic pathway crucial to stopping the growth of lung cancer cells.

Contact: Lori Sundeen Soderbergh
UT Southwestern Medical Center

Public Release: 7-Oct-2014
Journal of Clinical Oncology
Drug regimen enough to control immune disease after some bone marrow transplants
Johns Hopkins and other cancer researchers report that a very short course of a chemotherapy drug, called cyclophosphamide, not only can prevent a life-threatening immune response in some bone marrow transplant recipients, but also can eliminate such patients' need for the usual six months of immune suppression medicines commonly prescribed to prevent severe forms of this immune response. Patients receive cyclophosphamide for two days after their bone marrow transplant, in addition to two other chemotherapy drugs given before the transplant.
Otsuka Pharmaceutical

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 7-Oct-2014
Cancer Epidemiology, Biomarkers & Prevention
New at-risk group identified for gastrointestinal stromal tumors
Researchers at the University of California, San Diego School of Medicine have, for the first time, clearly defined the epidemiology of gastrointestinal stromal tumors, which occur primarily in the lining of the stomach and small intestine. One key finding: patients of Asian descent, who have not previously been identified as an at-risk population, are 1.5 times more likely than other patient groups to be diagnosed with this type of tumor.
National Institutes of Health, Gastrointestinal Stromal Tumor Research Fund

Contact: Jackie Carr
University of California - San Diego

Public Release: 7-Oct-2014
Cell Reports
Survival molecule helps cancer cells hide from the immune system
A new study shows that the molecule nuclear factor kappa B helps tumors grow by inhibiting the body's ability to detect cancer cells. The molecule suppresses immune surveillance mechanisms, including the production of cells that inhibit immune responses. The research suggests that cancer immune therapy might be improved if combined with NF-kB inhibitors, and it provides new details about interactions between cancer cells and non-cancer cells that assist tumor growth.
NIH/National Cancer Institute

Contact: Darrell E. Ward
Ohio State University Wexner Medical Center

Public Release: 6-Oct-2014
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Link between breast implants and cancer under investigation
An international research group including Viennese pathologist Lukas Kenner has reviewed cases of possible association between breast implants and a form of lymphoma that may develop tumors at a later stage. The researchers conclude that breast implants can cause a new subtype of the rare yet malignant lymphoma known as ALCL. The research results have been published in the journal Mutation Research.

Contact: Susanna Kautschitsch
University of Veterinary Medicine -- Vienna

Public Release: 6-Oct-2014
Journal of Experimental Medicine
'JAKing' up blood cancers, one cell at a time
A solitary cell containing a unique abnormality can result in certain types of blood cancers known as myeloproliferative neoplasms, according to researchers in Switzerland. The results open new opportunities to examine single mutant cells and follow tumor initiation and progression of human MPN cancers.
Swiss National Science Foundation, Swiss Cancer League

Contact: Rita Sullivan King
Rockefeller University Press

Public Release: 6-Oct-2014
Health Affairs
Cancer medicine: New, improved, expensive and exploited?
Two studies published in the October 2014 issue of Health Affairs by a University of Chicago health economist examine spending on oral anti-cancer drugs as well as a federal program designed to help the poor, which researchers say instead helps hospitals boost profits.
NIH/National Cancer Institute

Contact: John Easton
University of Chicago Medical Center

Public Release: 6-Oct-2014
Nature Communications
Tumors might grow faster at night
Weizmann Institute scientists reveal that a hormone that keeps us alert also suppresses the spread of cancer.

Contact: Yivsam Azgad
Weizmann Institute of Science

Public Release: 6-Oct-2014
Alimentary Pharmacology and Therapeutics
Blood levels of vitamin D may affect liver cancer prognosis
Vitamin D deficiency is linked with advanced stages of liver cancer and may be an indicator of a poor prognosis, according to a study of 200 patients with the disease who were followed for an average of 46 weeks.

Contact: Nicole Weingartner

Public Release: 6-Oct-2014
Alimentary Pharmacology and Therapeutics
Eating white meat and fish may lower risk of liver cancer
Eating lots of white meat -- such as poultry -- or fish may reduce the risk of developing liver cancer by 31 percent and 22 percent, respectively, according to a recent analysis of studies published between 1956 and 2013.

Contact: Nicole Weingartner

Public Release: 6-Oct-2014
Frontiers in Optics
The skin cancer selfie
Melanoma is the fifth most common cancer type in the US, and it's also the deadliest form of skin cancer. If caught early enough though, it is almost always curable. The gigapixel camera, developed by a team at Duke University, is essential 34 microcameras in one and has a high enough resolution to zoom in to a tiny freckle making routine screenings available to a larger number of people at a fraction of the cost.

Contact: Lyndsay Meyer
The Optical Society

Public Release: 6-Oct-2014
Alimentary Pharmacology and Therapeutics
Drug-loaded beads may help treat liver cancer
A new phase 1 safety trial has demonstrated that idarubicin-loaded beads are well tolerated by patients but are toxic to liver cancer cells. Idarubicin is an anthracycline that is currently used to treat leukemias.

Contact: Nicole Weingartner

Public Release: 6-Oct-2014
Alimentary Pharmacology and Therapeutics
Most liver cancer patients do not receive proper care
Many US patients with liver cancer -- even those with early stage disease that can often be cured -- do not receive treatment for their disease, according to an analysis of studies published between 1989 and 2013.

Contact: Nicole Weingartner

Public Release: 5-Oct-2014
Nature Structural and Molecular Biology
First pictures of BRCA2 protein show how it works to repair DNA
Scientists have taken pictures of the BRCA2 protein for the first time, showing how it works to repair damaged DNA.
Medical Research Council, Wellcome Trust

Contact: Sam Wong
Imperial College London

Public Release: 3-Oct-2014
Sexually Transmitted Infections
Alcohol consumption associated with increased risk of HPV infection in men, say Moffitt researchers
Men who consume more alcohol have a greater risk of human papillomavirus infection, according to a recent study by Moffitt Cancer Center researchers.

Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Showing releases 1026-1050 out of 1272.

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