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Showing releases 1026-1050 out of 1272.

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Public Release: 20-Jun-2014
Cancer
For cancer patients, new tool predicts financial pain
Cancer care has a new side effect. Patients now have to deal with 'financial toxicity,' the expense, anxiety and loss of confidence confronting those who face large, unpredictable costs, often compounded by decreased ability to work. A team of cancer specialists describe COST, the first tool to measure a patient's risk for, and ability to tolerate, financial stress.
National Institutes of Health

Contact: John Easton
John.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center

Public Release: 19-Jun-2014
Cell
Cleveland Clinic researchers discover protein that inhibits tumor growth
A previously unknown variant of an extensively studied protein has been found to inhibit the growth of tumors and slow the development of new blood vessels necessary for cancers to metastasize, according to Cleveland Clinic research published today in Cell.
National Institutes of Health

Contact: Laura Ambro
ambrol@ccf.org
216-636-5876
Cleveland Clinic

Public Release: 19-Jun-2014
Cell
Computer-designed protein triggers self-destruction of Epstein-Barr-infected cancer cells
A protein molecule, BINDI, has been built to trigger self-destruction of cancer cells infected with the Epstein-Barr virus.
National Institutes of Health, Washington Life Sciences Discovery Fund, US Defense Threat Reduction Agency, and others

Contact: Elizabeth Hunter
elh415@uw.edu
206-616-3192
University of Washington Health Sciences/UW Medicine

Public Release: 19-Jun-2014
Cell
Stanford bioengineers invent a way to speed up drug discovery
The 500 or so kinase proteins are particularly important to drug discovery. Kinases are messenger/signaling proteins that regulate and orchestrate the actions of other proteins. Proper kinase activity maintains health. Irregular activity is linked to cancer and other diseases. Many drugs seek to either boost or suppress kinase activity. Stanford bioengineers have invented a way to observe and report on the behavior of these signaling proteins as they work inside living cells.

Contact: Tom Abate
tabate@stanford.edu
650-736-2245
Stanford School of Engineering

Public Release: 19-Jun-2014
JAMA Surgery
African American women with breast cancer less likely to have newer, recommended surgical procedure
African American women with early stage, invasive breast cancer were 12 percent less likely than Caucasian women with the same diagnosis to receive a minimally invasive technique, axillary sentinel lymph node biopsy, even as the procedure had become the standard of surgical practice, according to research from The University of Texas MD Anderson Cancer Center.

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center

Public Release: 19-Jun-2014
PLOS Genetics
Strict diet suspends development, doubles lifespan of worms
Researchers at Duke University found that taking food away from C. elegans triggers a state of arrested development: while the organism continues to wriggle about, foraging for food, its cells and organs are suspended in an ageless, quiescent state. When food becomes plentiful again, the worm develops as planned, but can live twice as long as normal.
American Cancer Society, National Institutes of Health

Contact: Karl Bates
karl.bates@duke.edu
919-681-8054
Duke University

Public Release: 19-Jun-2014
Journal of the National Cancer Institute
A shorter time to the first cigarette of the day is associated with risk of lung cancer
Standard markers of nicotine dependency include cigarettes smoked per day, duration of smoking, and cumulative exposure (pack years), but another marker of addiction, time to first cigarette of the day, may also be associated with the risk of getting lung cancer in both heavy and light smokers, according to a study published June 19 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
Zachary.Rathner@oup.com
919-677-2697
Oxford University Press USA

Public Release: 19-Jun-2014
Cell
UV-induced beta-endorphin production causes addiction-like symptoms in mice
A new study from Massachusetts General Hospital investigators adds important support to the theory that ultraviolet light can actually be addictive, finding that chronic UV exposure raises circulating levels of beta-endorphin in mice and that UV-habituated mice exhibit withdrawal symptoms if beta-endorphin activity is blocked.
National Institutes of Health, Melanoma Research Alliance, US-Israel Binational Science Foundation, Adelson Medical Research Foundation

Contact: Terri Ogan
togan@partners.org
617-726-0954
Massachusetts General Hospital

Public Release: 19-Jun-2014
Cell
Feel-good hormones could cause UV addiction
Sun lovers eagerly flock to the beach every summer, despite widespread awareness of the risk of skin cancer. A new study reveals that chronic exposure to UV radiation causes the release of feel-good hormones called endorphins, which act through the same pathway as heroin, leading to physical dependence, tolerance, and addiction-like behavior in rodents. The findings could explain why people have an instinctive desire to be in the sun, despite its known health risks.

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press

Public Release: 19-Jun-2014
Lancet Oncology
Researcher discovers ovarian cancer treatment
Doctors at the University of Arizona Cancer Center at St. Joseph's Hospital and Medical Center in Phoenix reported today in Lancet Oncology that a new treatment for ovarian cancer can improve response rates (increase the rate of tumor shrinkage) and prolong the time until cancers recur. In addition, this breakthrough showed a trend in improving survival although these data are not yet mature.

Contact: lynne Reaves
lynne.reaves@dignityhealth.org
602-406-4734
St. Joseph's Hospital and Medical Center

Public Release: 19-Jun-2014
Cell
Scientists identify additional challenges in KRAS-driven cancers
Scientists have redoubled efforts to disable the mutated cancer gene KRAS, which confers an especially poor prognosis and has proved extraordinarily difficult to target. New research reported in the journal Cell has identified an additional hurdle: inhibiting KRAS can activate a backup pathway in cancer cells that enables them to survive and thrive in the oncogene's absence.
NIH/National Cancer Institute, Koch Institute

Contact: Teresa M Herbert
teresa_herbert@dfci.harvard.edu
617-632-5653
Dana-Farber Cancer Institute

Public Release: 19-Jun-2014
Proceedings of the National Academy of Sciences
Possible new combination treatment for cancer
Scientists at the Sahlgrenska Academy have developed a new cancer treatment that has proved to be effective in mice. The treatment, which is presented in the prestigious scientific journal PNAS, is based on newly discovered properties of the so-called BET bromodomain inhibitors.

Contact: Krister Svahn
krister.svahn@sahlgrenska.gu.se
0046-031-786-3869
University of Gothenburg

Public Release: 19-Jun-2014
Cell Reports
A new tool to confront lung cancer
Published online in Cell Reports on June 19, Huntsman Cancer Institute investigators report that misregulation of two genes, sox2 and lkb1, drives squamous cell lung cancer in mice. The discovery uncovers new treatment strategies, and provides a clinically relevant mouse model in which to test them.
US Department of Defense, V Foundation for Cancer Research, Damon Runyon Cancer Research Foundation

Contact: Linda Aagard
Linda.Aagard@hci.utah.edu
801-587-7639
University of Utah Health Sciences

Public Release: 19-Jun-2014
Optics Letters
A better imager for identifying tumors
Researchers have developed a new technique that could improve surgeons' ability to identify cancerous tumors and remove them in real-time in the operating room. The new imaging system combines two techniques -- near-IR fluorescent imaging and visible light reflectance imaging -- to get a much better picture of the tissue. The work, from the University of Arizona and Washington University in St. Louis, was published in the journal Optics Letters today.

Contact: Lyndsay Meyer
lmeyer@osa.org
202-416-1435
The Optical Society

Public Release: 19-Jun-2014
Cell
Mechanism discovered for attaching an 'on' switch that helps cells accessorize proteins
St. Jude Children's Research Hospital scientists have discovered how an important 'on' switch is attached to the machinery that cells rely on to adapt thousands of proteins to meet changing conditions. The research appears in the current issue of the journal Cell.
NIH/National Cancer Institute, NIH/National Institute of General Medical Sciences, Howard Hughes Medical Institute, Damon Runyon Cancer Research Foundation, ALSAC

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Public Release: 19-Jun-2014
JAMA
Drug shows promise for the first time against metastatic melanoma of the eye
For the first time, a therapy has been found that can delay progression of metastatic uveal melanoma, a rare and deadly form of melanoma of the eye.
NIH/National Cancer Institute

Contact: Karin Eskenazi
Ket2116@columbia.edu
Columbia University Medical Center

Public Release: 19-Jun-2014
Cell Stem Cell
Scientists identify link between stem cell regulation and the development of lung cancer
UCLA researchers led by Dr. Brigitte Gomperts have discovered the inner workings of the process thought to be the first stage in the development of lung cancer. Their study explains how factors that regulate the growth of adult stem cells that repair tissue in the lungs can lead to the formation of precancerous lesions.

Contact: Shaun Mason
smason@mednet.ucla.edu
310-206-2805
University of California - Los Angeles

Public Release: 19-Jun-2014
Pigment Cell & Melanoma Research
Study offers evidence that sunscreen use in childhood prevents melanoma in adults
Research conducted at the Texas Biomedical Research Institute, published in the latest issue of the scientific journal Pigment Cell and Melanoma, has established unequivocally in a natural animal model that the incidence of malignant melanoma in adulthood can be dramatically reduced by the consistent use of sunscreen in infancy and childhood.
Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation

Contact: Mary Uhlig
muhlig@dublinandassociates.com
210-227-0221 x223
Texas Biomedical Research Institute

Public Release: 19-Jun-2014
Gynecologic Oncology
Finding the Achilles' Heel of ovarian tumor growth
A team of scientists, led by principal investigator David D. Schlaepfer, PhD, professor in the Department of Reproductive Medicine at the University of California, San Diego School of Medicine report that small molecule inhibitors to a protein called focal adhesion kinase selectively prevent the growth of ovarian cancer cells as tumor spheroids.
National Institutes of Health, Nine Girls Ask?

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 19-Jun-2014
Cell
New target: Researchers identify pancreatic cancer resistance mechanism
Pancreatic cancer tumors addicted to mutant Kras signaling for their growth and progression have a ready-made substitute to tap if they're ever forced to go cold-turkey on the mutant oncogene, scientists at The University of Texas MD Anderson Cancer Center report in the journal Cell.

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center

Public Release: 18-Jun-2014
American Society of Clinical Oncology 2014 Conference
Breathalyzer test may detect deadliest cancer
Lung cancer causes more deaths in the US than the next three most common cancers combined. Now a new breathalyzer test, embedded with a 'NaNose' nanotech chip to literally 'sniff out' cancer tumors, has been developed by a team of international researchers including Prof. Nir Peled of Tel Aviv University's Sackler Faculty of Medicine. It may turn the tide by both accurately detecting lung cancer and identifying its stage of progression.

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University

Public Release: 18-Jun-2014
eLife
Scripps Research Institute scientists reveal molecular 'yin-yang' of blood vessel growth
Biologists at The Scripps Research Institute have discovered a crucial process that regulates the development of blood vessels. The finding could lead to new treatments for disorders involving abnormal blood vessel growth, including common disorders such as diabetic retinopathy and cancer.
National Institutes of Health, National Foundation for Cancer Research

Contact: Madeline McCurry-Schmidt
madms@scripps.edu
858-784-9254
Scripps Research Institute

Public Release: 18-Jun-2014
Journal of Clinical Oncology
Telephone call is effective support when breast cancer treatment includes weight loss
A series of simple telephone calls can make a profound difference in helping women to meet their treatment goals for breast cancer, according to a randomized trial of women who are also obese.

Contact: Polly Thompson
pthompson@lunenfeld.ca
41-658-648-002-046
Lunenfeld-Tanenbaum Research Institute

Public Release: 18-Jun-2014
PLOS Genetics
Following direction: How neurons can tell top from bottom and front from back
The question of how neurons and their axons establish spatial polarity and direction in tissues and organs is a fundamental question of any organism or biological system. Our cells and axons precisely orient themselves in response to external cues, but what are the core pathways and how are they integrated?
Canadian Institutes of Health Research

Contact: Polly Thompson
pthompson@lunenfeld.ca
41-658-648-002-046
Lunenfeld-Tanenbaum Research Institute

Public Release: 18-Jun-2014
Cancer
False negative results found in prognostic testing for breast cancer
Researchers retested tumor samples from a large group of women and found that 22 out of 530 women had their tumor type incorrectly classified in local labs, which precluded them from effective treatment options.
Roche-Genentech, Inc.

Contact: Donna Dubuc
donna.M.Dubuc@Dartmouth.edu
603-653-3615
The Geisel School of Medicine at Dartmouth

Showing releases 1026-1050 out of 1272.

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