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Showing releases 1026-1050 out of 1124.

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Public Release: 19-Jun-2012
Biochemistry
Moving 3D computer model of key human protein is powerful new tool in fight against cancer
Researchers long have relied on static images of human P-glycoprotein, a major contributor to chemotherapy failure in recurring cancers. Now biochemist John Wise, Southern Methodist University, Dallas, has deduced its structure and built a moving 3D computer model. Wise is pairing this powerful new tool with SMU's high-performance supercomputer in search of a potent inhibitor. Virtual screening of more than eight million compounds has resulted in promising leads that may help stop chemotherapy failures.
National Institutes of Health, NIH/National Institute of General Medical Sciences

Contact: Margaret Allen
mallen@smu.edu
214-768-7664
Southern Methodist University

Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges
Adding erlotinib to bevacizumab/chemoradiotherapy regimen for pancreatic cancer safe, tolerable
The addition of high doses of erlotinib to the treatment regimen of bevacizumab and capecitabine with radiotherapy seems to benefit patients with locally advanced pancreatic cancer, according to results of a phase I study presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held June 18-21.
Genentech

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges
Biomarker panel to screen for pancreatic cancer may be possible
The development of a highly accurate, blood-based pancreatic adenocarcinoma screen that would be accurate enough to test the general population for this deadly disease may not be far out of reach, according to data presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held June 18-21, 2012.

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges
Sun exposure and sun-sensitive skin type decreased risk for pancreatic cancer
High levels of ultraviolet radiation at an individual's birth location, sun-sensitive skin type and a history of skin cancer each decreased risk for pancreatic cancer, according to study results presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held June 18-21.

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges
Inhibiting Hedgehog signaling pathway may improve pancreatic cancer treatment
Combining a new targeted therapy with standard chemotherapy may help defeat pancreatic cancer, according to results presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held June 18-21.

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 19-Jun-2012
Cancer Discovery
Abnormal gene product associated with prostate cancer generated by unusual mechanism
Researchers have identified a potential new pathway in prostate cancer cells by which cancer-driving gene products can be generated, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.
Stand Up To Cancer

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges
RLIP76 contributes to pancreatic cancer cell resistance to chemotherapy and radiation
Researchers at the City of Hope Comprehensive Cancer Center have not only identified a protein that allows pancreatic cancer cells to resist therapy but also developed a way to block it, according to results presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held June 18-21.

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges
Metformin treatment caused cancer stem cell death in pancreatic cancer cell lines
Results of some preclinical trials have shown that low doses of the antidiabetic drug metformin may effectively destroy cancer stem cells, a group of cells that are considered to be responsible for tumor initiation and, because they are resistant to standard chemotherapies, tumor relapse.

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges
Nerve growth factors elevated in pancreatic cancer model
Severe pain is a major symptom of pancreatic cancer. The results of a new study show that four different factors involved in the growth and maintenance of nerves are elevated in a mouse model of pancreatic cancer. This is a step forward in understanding the relationship between the development of pain and the progression of pancreatic cancer.
NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute of Diabetes and Digestive and Kidney Diseases, Shirley Hobbs Martin Memorial Fund

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 19-Jun-2012
International Journal of Cancer
Does night work put women's health at risk?
The results of a study carried out by the researchers of the Inserm unit 1018 and published in the International Journal of Cancer show that the risk of developing breast cancer is higher among women who have worked at night. The study, carried out in France and named the CECILE study, compared the careers of 1,200 women who had developed breast cancer between 2005 and 2008 with the careers of 1,300 other women.

Contact: Press Inserm
presse@inserm.fr
INSERM (Institut national de la santé et de la recherche médicale)

Public Release: 19-Jun-2012
PLOS Genetics
23andMe contributes to genetic discoveries related to male pattern baldness
23andMe has contributed to the finding of six novel genetic associations for early onset male pattern baldness in a genome-wide association study now published online in the journal PLoS Genetics. The study found that even after accounting for this shared association, men were still more likely to report both male pattern baldness and Parkinson's disease than would be expected by chance. This suggests that there may be additional shared genetic or environmental risk factors that predispose towards both conditions.
23andMe

Contact: Jane E. Rubinstein
jrubinstein@rubenstein.com
212-843-8287
23andMe Inc.

Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges
Genetic marker in vitamin D receptor gene associated with increased pancreatic cancer survival
Pancreatic cancer patients with a genetic marker linked to increased expression of the receptor for vitamin D have higher rates of overall survival, according to findings presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held June 18-21.

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 19-Jun-2012
Journal of Cancer Survivorship
Long-term cancer survivors struggle to keep regular work hours
Long-term cancer survivors take sick leave more often than their disease-free colleagues, suggesting that they struggle at work despite their ability to work five years after diagnosis. These findings by Steffen Torp, from Vestfold University College in Norway, and colleagues is published online in Springer's Journal of Cancer Survivorship.
Norwegian Cancer Society

Contact: Joan Robinson
joan.robinson@springer.com
49-622-148-78130
Springer

Public Release: 19-Jun-2012
Blood
Inhibitors of shuttle molecule show promise in acute leukemia
A novel family of experimental agents that blocks a molecule from shuttling proteins out of the cell nucleus might offer a new treatment for people with acute leukemia. The agents, called KPT-SINEs (selective inhibitors of nuclear export), target a transport protein called CRM1. The study shows that these agents inhibit leukemia-cell proliferation, arrest cell division, and induce cell death and differentiation. In an animal model, KPT-SINEs extended survival by 46 percent.
NIH/National Cancer Institute, Pelotonia Fellowship award

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center

Public Release: 19-Jun-2012
PLOS ONE
A new indicator for breast cancer relapse identified
Researchers at the IMIM have proven that the absence of the 14-3-3 protein sigma in breast cancer cells is directly associated with these cells' capacity to activate the signaling of a protein complex called NF-kB, which is related to tumor progression. The activation of NF-kB in tumors was also identified as the best indicator for relapse in breast cancer patients, compared to other parameters currently used, such as the presence of affected ganglions or the tumor's size and degree.

Contact: Marta Calsina
mcalsina@imim.es
34-933-160-680
IMIM (Hospital del Mar Medical Research Institute)

Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges
A combination of TH-302 and radiation reduced human pancreatic tumor growth in hypoxic xenografts
A combination of the prodrug TH-302 and radiation may provide an effective treatment strategy for pancreatic cancer, according to preclinical results presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held June 18-21.

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 19-Jun-2012
American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges
Leukemia inhibitory factor may be a promising target against pancreatic cancer
Pancreatic cancer is one of the deadliest forms of cancer, defying most treatments. Its ability to evade therapy may be attributable to the presence of cancer stem cells, a subset of cancer cells present in pancreatic tumors that drive tumor growth by generating bulk tumor cells. Cancer stem cells are notorious for their ability to resist traditional chemotherapies.

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 18-Jun-2012
Journal of Clinical Investigation
JCI early table of contents for June 18, 2012
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, June 18, 2012, in the JCI: "Combating fungal eye infections"; "Molecular effects of social isolation on neurotransmission"; "Disrupted adenosine signaling contributes to schizophrenia"; "Imaging immune cell recruitment into the beating heart"; and more.

Contact: Sarah Jackson
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 18-Jun-2012
Annals of Internal Medicine
Annals of Internal Medicine tip sheet for June 19, 2012, online issue
This release contains information about articles being published in the June 19 issue of Annals of Internal Medicine.

Contact: Abbey Anderson
aanderson@acponline.org
215-351-2656
American College of Physicians

Public Release: 18-Jun-2012
Archives of Otolaryngology - Head & Neck Surgery
Study examines chronic inflammation in oral cavity and HPV status of head and neck cancers
Among patients with head and neck squamous cell carcinomas, a history of chronic inflammation in the mouth (periodontitis, i.e. gum disease) may be associated with an increased risk of tumors positive for human papillomavirus, according to a report published Online First by Archives of Otolaryngology – Head & Neck Surgery, a JAMA Network publication.

Contact: Sara Saldi
saldi@buffalo.edu
716-645-4593
JAMA and Archives Journals

Public Release: 18-Jun-2012
Genome Research
Bioinformatics experts at the CNIO explore additional coding potential hidden in the human genome
Sequencing the human genome was just the first step. The next challenge is of the kind that makes history: To decode the genome, and understand how the information needed to construct a human being can be packaged into a single molecule. And there are a lot more than loose ends in the way of a solution. A group of bioinformatics experts at the Spanish National Cancer Research Centre in Madrid have published findings which point to still unexplored coding potential within the genome.

Contact: Juan J. Gomez
juanj.gomez@cnio.es
34-917-328-000
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 18-Jun-2012
Molecular Cell
UCLA scientists discover how key enzyme involved in aging, cancer assembles
UCLA biochemists have mapped the structure of a key protein-RNA complex that is required for the assembly of telomerase, an enzyme important for both cancer and aging.

Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles

Public Release: 18-Jun-2012
American Journal of Hematology
Pediatric regime of chemotherapy proves more effective for young adults
Dr. Ron Ram of Tel Aviv University has determined that a pediatric chemotherapy regime improves the chances of young adults with leukemia for long-term survival and decreases their mortality rate. And the need for a bone marrow transplant, a common treatment for young adults with ALL, can be avoided as well.

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University

Public Release: 18-Jun-2012
Model Organisms to Human Biology: Cancer Genetics
Fish shed light on human melanoma
Zebrafish, a transparent member of the minnow family, are providing insight into human melanoma – a form of skin cancer – that may lead to new or repurposed drug treatments, for skin and other cancers. This will be reported by researchers from the Weill Cornell Medical College in New York City at the Genetics Society of America's "Model Organisms to Human Biology: Cancer Genetics" Meeting, June 17-20, 2012, in Washington, D.C at the Omni Shoreham Hotel.

Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America

Public Release: 15-Jun-2012
Genes & Development
Scientists discover mechanism that promotes lung cancer growth and survival
A multi-institutional research study has uncovered a new mechanism that may lead to unique treatments for lung cancer, one of the leading causes of death worldwide.

Contact: John Wallace
wallacej@vcu.edu
804-628-1550
Virginia Commonwealth University

Showing releases 1026-1050 out of 1124.

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