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Showing releases 1026-1050 out of 1294.

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Public Release: 24-Jun-2014
Journal of Clinical Investigation
Estrogen receptor β limits breast cancer growth and indicates outcome
In a June 24th study in the Journal of Clinical Investigation, Rong Li and colleagues at the University of Texas determined that activation of the estrogen receptor β (ERβ) limits tumor cell growth.

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 24-Jun-2014
JAMA
3D mammography detects more invasive cancers and reduces call-back rates
Reporting in the June 25 issue of JAMA, researchers from Penn Medicine and other institutions found that 3D mammography -- known as digital breast tomosynthesis -- found significantly more invasive, or potentially lethal, cancers than a traditional mammogram alone and reduced call-backs for additional imaging.
NIH/National Cancer Institute

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine

Public Release: 24-Jun-2014
Clinical Cancer Research
Combo tumor imaging can distinguish malignant & benign breast tumors, help avoid biopsies
Imaging breast tumors using four approaches together can better distinguish malignant breast tumors from those that are benign, compared with imaging using fewer approaches, and this may help avoid repeat breast biopsies, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.
Austrian Society of Senology Scientific Funding Award, Austrian National Bank, Medical Scientific Fund of the Mayor of Vienna Project

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 24-Jun-2014
Proceedings of the National Academy of Sciences
Cell division discovery could optimise timing of chemotherapy and explain some cancers
Research led by the University of Warwick in collaboration with groups in Nice and Rotterdam has been able to demonstrate how the cycle of cell division in mammalian cells synchronizes with the body's own daily rhythm, its circadian clock. The study not only helps to explain why people with sustained disrupted circadian rhythms can be more susceptible to cancer, it may also help establish the optimal time of day to administer chemotherapy.
Biotechnology and Biological Sciences Research Council

Contact: a.t.frew@warwick.ac.uk
A.T.Frew@warwick.ac.uk
University of Warwick

Public Release: 24-Jun-2014
JAMA
3D Mammography finds more invasive cancers and reduces unnecessary recalls
3D Mammography finds significantly more invasive cancers and reduces unnecessary recalls, according to a large, retrospective study published in June 25 issue of the Journal of the American Medical Association. The study features data from University Hospitals Case Medical Center Seidman Cancer Center. The study, the largest of its kind, focused on the impact of 3D mammography at a diverse range of sites across the US, looking at nearly half a million mammograms at 13 sites.

Contact: Alicia Reale
alicia.reale@uhhhospitals.org
University Hospitals Case Medical Center

Public Release: 24-Jun-2014
JAMA
Addition of 3-D imaging technique to mammography increases breast cancer detection rate
The addition of tomosynthesis, a 3-dimensional breast imaging technique, to digital mammography in more than 170,000 examinations was associated with a decrease in the proportion of patients called back for additional imaging and an increase in the cancer detection rate, according to a study in the June 25 issue of JAMA.

Contact: Mickey Ramirez
Mickey.Ramirez@advocatehealth.com
847-723-5637
The JAMA Network Journals

Public Release: 24-Jun-2014
Nature Communications
Cancer: The roots of evil go deep in time
Every year around 450,000 people in Germany are diagnosed with cancer. Each one of them dreams of a victory in the battle against it. But can cancer ever be completely defeated? Researchers at Kiel University have now reached a sobering conclusion.

Contact: Claudia Eulitz
ceulitz@uv.uni-kiel.de
Kiel University

Public Release: 24-Jun-2014
Neurosurgery
To advance care for patients with brain metastases: Reject five myths
Professional pessimism and out-of-date 'myths,' rather than current science, are guiding and compromising the care of patients with cancer that has spread to the brain, says a blue-ribbon panel of experts from leading academic centers in an article published online June 24 in Neurosurgery. The authors identify five key misconceptions that must be addressed -- and how to address them -- in order to advance new thinking in the treatment of brain cancer.

Contact: Ryan Jaslow
ryan.jaslow@nyumc.org
212-404-3511
NYU Langone Medical Center / New York University School of Medicine

Public Release: 24-Jun-2014
Journal of Experimental Medicine
New possibilities for leukemia therapy with a novel mode of leukemia cell recognition
Scientists at A*STAR's Singapore Immunology Network have discovered a new class of lipids in the leukemia cells that are detected by a unique group of immune cells. By recognizing the lipids, the immune cells stimulate an immune response to destroy the leukemia cells and suppress their growth. The newly identified mode of cancer cell recognition by the immune system opens up new possibilities for leukemia immunotherapy.

Contact: Tan Yun Yun
tan_yun_yun@a-star.edu.sg
65-682-66273
Biomedical Sciences Institutes (BMSI)

Public Release: 24-Jun-2014
Cancer Research
Mayo Clinic researchers say gene in brain linked to kidney cancer
A gene known to control brain growth and development is heavily involved in promoting clear cell renal cell carcinoma, the most common form of kidney cancer, researchers from Mayo Clinic in Florida are reporting.
NIH/National Cancer Institute

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-0746
Mayo Clinic

Public Release: 23-Jun-2014
Nature
Cancer genes hijack enhancers
Unlike most other forms of cancer, medulloblastomas exhibits very few mutations in growth-promoting genes. In collaboration with an international team of colleagues, scientists from the German Cancer Research Center have now made an important discovery about a particularly malignant subgroup of medulloblastomas: often the cancer-causing genes are transcribed at higher or lower levels than normal. This change is due to regulatory mechanisms that were previously unknown. For example, one cancer-gene hijacks a so-called 'enhancer.'
German Cancer Aid, German Federal Ministry of Education and Research

Contact: Dr. Sibylle Kohlstädt
s.kohlstaedt@dkfz.de
German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)

Public Release: 23-Jun-2014
Nature Genetics
New study offers potential avenues for treatment of deadly nasopharyngeal cancer
A team of scientists from the Cancer Science Institute of Singapore at the National University of Singapore, National University Cancer Institute Singapore and National University Hospital Singapore, discovered a distinct mutational signature and nine significantly mutated genes associated with nasopharyngeal cancer, paving the way to developing novel therapies for this deadly disease.

Contact: Kimberley Wang
kimberley.wang@nus.edu.sg
65-660-11653
National University of Singapore

Public Release: 23-Jun-2014
Cancer
Family dysfunction a strong predictor of emotional problems in children of cancer patients
A cancer diagnosis affects the whole family, and a significant number of children of cancer patients may be at risk for emotional and behavioral problems.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
Wiley

Public Release: 23-Jun-2014
PLOS ONE
Study sheds light on racial disparity in colon cancer
African-Americans with colon cancer are half as likely as Caucasian patients to have a type of colon cancer that is linked to better outcomes. The finding may provide insight into why African-Americans are more likely to die of colon cancer than Caucasians with the same stage of disease.
National Institutes of Health

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 23-Jun-2014
Nature Cell Biology
The colon has a safety mechanism that restricts tumor formation
Colon cancer development starts with the formation of benign tumors called adenomas. It is estimated that between 30 and 50 percent of people over 50 will develop one of these tumors. These adenomas or polyps are pre-cancerous lesions that over many years, can progress to colon cancer. Scientists at the IRB Barcelona have discovered that the colon has a safety mechanism to restrict the formation and growth of adenomas. The study was published on Sunday in Nature Cell Biology.
European Research Council, Spanish Ministry of Economy and Competitiviness, Josef Steiner Foundation

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)

Public Release: 23-Jun-2014
Annals of Internal Medicine
Annals of Internal Medicine tip sheet for June 24, 2014
The June 24, 2014, Annals of Internal Medicine contains papers titled: 'Task Force recommends one-time screening for abdominal aortic aneurysms in older male smokers' and 'Caution advised before implementing widespread lung cancer screening among Medicare beneficiaries.'

Contact: Megan Hanks
mhanks@acponline.org
215-351-2656
American College of Physicians

Public Release: 23-Jun-2014
ICE/ENDO 2014
BPA stimulates growth of breast cancer cells, diminishes effect of treatment
Bisphenol A, a chemical commonly used in plastics, appears to increase the proliferation of breast cancer cells, according to Duke Medicine researchers presenting at an annual meeting of endocrine scientists.
NIH/National Cancer Institute, Duke/Department of Surgery D.P. Bolognesi Award, Duke Cancer Institute, American Cancer Society

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

Public Release: 23-Jun-2014
Journal of Biological Chemistry
SLU researchers see possible answer to chemo pain in a multiple sclerosis drug
Saint Louis University researchers describe two discoveries: a molecular pathway by which a painful chemotherapy side effect happens and a drug that may be able to stop it.
Leukemia and Lymphoma Society, Mayday Fund, Saint Louis University Cancer Center

Contact: Carrie Bebermeyer
bebermcl@slu.edu
314-977-8015
Saint Louis University

Public Release: 23-Jun-2014
Journal of Physical Chemistry Letters
Cancer chain in the membrane
Supercomputer simulations reveal clusters of a protein linked to cancer warp cell membranes -- findings could help design new anticancer drugs. Researchers at the UTHealth Medical School used XSEDE/TACC supercomputers Lonestar and Stampede to simulate molecular dynamics of Ras protein clusters at the cell membrane. Simulations give greater understanding of Ras protein role in cancer and provide models for further experimental tests.
National Institutes of Health

Contact: Faith Singer-Villalobos
faith@tacc.utexas.edu
512-232-5771
University of Texas at Austin, Texas Advanced Computing Center

Public Release: 23-Jun-2014
Nature Communications
Scientists use X-rays to look at how DNA protects itself from UV light
The molecular building blocks that make up DNA absorb ultraviolet light so strongly that sunlight should deactivate them -- yet it does not. Now scientists have made detailed observations of a 'relaxation response' that protects these molecules, and the genetic information they encode, from UV damage.

Contact: Andrew Gordon
agordon@slac.standford.edu
650-926-2282
DOE/SLAC National Accelerator Laboratory

Public Release: 23-Jun-2014
Cell Reports
Long non-coding RNAs can encode proteins after all
Case Western Reserve School of Medicine scientists have made an extraordinary double discovery. First, they have identified thousands of novel long non-coding ribonucleic acid transcripts. Second, they have learned that some of them defy conventional wisdom regarding lncRNA transcripts, because they actually do direct the synthesis of proteins in cells. Both of the breakthroughs are detailed in the June 12 issue of Cell Reports.
NIH, National Science Foundation

Contact: Jeannette Spalding
jeannette.spalding@case.edu
216-368-3004
Case Western Reserve University

Public Release: 23-Jun-2014
Journal of Men's Health
Is focal treatment for prostate cancer as effective in the long-term as radical therapies?
Focal therapy for prostate cancer, in which only the tumor tissue is treated with cryoablation (freezing), can prolong life, result in less complications such as incontinence, and improve post-treatment quality of life. But the long-term effectiveness of focal treatments has not been well-studied. A new analysis that followed patients treated with optimized cryoablation of prostate cancer for an average of 10 years post-treatment is published in Journal of Men's Health.

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 23-Jun-2014
Endocrine Society Annual Meeting
Anti-androgen therapy for triple-negative breast cancer may benefit lower-androgen tumors
A new University of Colorado Cancer Center study being presented today at the Endocrine Society Annual Meeting shows that even triple negative breast cancers expressing very low levels of androgen receptor may benefit from this therapy.

Contact: Erika Matich
erika.matich@ucdenver.edu
University of Colorado Denver

Public Release: 23-Jun-2014
Pediatrics
Young indoor tanning increases early risk of skin cancer
Dartmouth researchers have found that early exposure to the ultraviolet radiation lamps used for indoor tanning is related to an increased risk of developing basal cell carcinomas at a young age. Their findings are reported in the July 2014 issue of Pediatrics. Since indoor tanning has become increasingly popular among adolescents and young adults, this research calls attention to the importance of counseling young people about the risk of indoor tanning.
National Institutes of Health, NIH/National Cancer Institute, NIH/National Institute for Environmental Health, US Environmental Protection Agency

Contact: Robin Dutcher
Robin.Dutcher@hitchcock.org
603-653-9056
The Geisel School of Medicine at Dartmouth

Public Release: 23-Jun-2014
Proceedings of the National Academy of Sciences
Delivering drugs on cue
Current drug-delivery systems used to administer chemotherapy to cancer patients typically release a constant dose of the drug over time -- but a new study challenges this 'slow and steady' approach and offers a novel way to locally deliver the drugs 'on demand,' as reported in the Proceedings of the National Academy of Sciences.
Harvard University, NIH/National Institute of Dental and Craniofacial Research, California Institute for Regenerative Medicine

Contact: Kristen Kusek
kristen.kusek@wyss.harvard.edu
617-432-8266
Wyss Institute for Biologically Inspired Engineering at Harvard

Showing releases 1026-1050 out of 1294.

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