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Public Release: 22-Aug-2014
Inflammatory Bowel Diseases
Study shows epigenetic changes in children with Crohn's disease
A new study finds a wide range of epigenetic change -- alterations in DNA across the genome that may be related to key environmental exposures -- in children with Crohn's disease, reports Inflammatory Bowel Diseases, official journal of the Crohn's & Colitis Foundation of America. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health

Public Release: 22-Aug-2014
Journal of Thoracic Oncology
Deletion predicts survival in advanced non-small cell lung cancer
Bcl-2-like protein 11 deletion in advanced non-small cell lung cancer is associated with shorter progression free survival in epidermal growth factor receptor tyrosine kinase inhibitor or chemotherapy treated Asian patients. Also, Bcl-2-like protein 11 deletion independently predicts overall survival of advanced non-small cell lung cancer patients.

Contact: Rob Mansheim
rob.mansheim@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Public Release: 22-Aug-2014
Journal of the National Cancer Institute
Scientists map risk of premature menopause after cancer treatment
Women treated for the cancer Hodgkin lymphoma will be able to better understand their risks of future infertility after researchers estimated their risk of premature menopause with different treatments. The findings, set out in the Journal of the National Cancer Institute, are based on the experience of more than 2,000 young women in England and Wales treated for the cancer over a period of more than 40 years.

Contact: Graham Shaw
henry.french@icr.ac.uk
020-715-35380
Institute of Cancer Research

Public Release: 22-Aug-2014
Nature Communications
Genetics and lifestyle have a strong impact on biomarkers for inflammation and cancer
In a new study published in Nature Communications, research scientists from Uppsala University present for the first time a large-scale study of the significance of genetic, clinical and lifestyle factors for protein levels in the bloodstream. The results of the study show that genetics and lifestyle are determining factors for protein levels, a discovery which greatly influences the possibilities for using more biomarkers to identify disease.

Contact: Stefan Enroth
stefan.enroth@igp.uu.se
46-018-471-4913
Uppsala University

Public Release: 22-Aug-2014
Cell Death & Disease
New enzyme targets for selective cancer therapies
A University of Alberta team has designed compounds that target brain cancer.

Contact: Bryan Alary
bryan.alary@ualberta.ca
780-492-0436
University of Alberta

Public Release: 22-Aug-2014
Preventive Medicine
Women with severe, chronic health issues are screened for breast cancer less often
Women with severe disabilities and multiple chronic conditions are screened for breast cancer less often than women with no disabilities or no chronic conditions, a new study has found.

Contact: Geoff Koehler
koehlerg@smh.ca
416-864-6060 x6537
St. Michael's Hospital

Public Release: 22-Aug-2014
Cancer Epidemiology
Smokers consume same amount of cigarettes regardless of nicotine levels
Cigarettes with very low levels of nicotine may reduce addiction without increasing exposure to toxic chemicals, according to a new study from the University of Waterloo.

Contact: Pamela Smyth
psmyth@uwaterloo.ca
519-888-4777
University of Waterloo

Public Release: 21-Aug-2014
Cancer Cell
Sequence of rare kidney cancer reveals unique alterations involving telomerase
An international scientific collaboration led by Baylor College of Medicine has revealed clues about genetic alterations that may contribute to a rare form of kidney cancer, providing new insights not only into this rare cancer but other types as well.

Contact: Glenna Picton
picton@bcm.edu
713-798-7973
Baylor College of Medicine

Public Release: 21-Aug-2014
JAMA Otolaryngology Head Neck Surgery
Surgery associated with better survival for patients with advanced laryngeal cancer
Patients with advanced laryngeal cancer appear to have better survival if they are treated with surgery than nonsurgical chemoradiation.

Contact: Sid Dinsay
sid.dinsay@mountsinai.org
212-241-9200
The JAMA Network Journals

Public Release: 21-Aug-2014
Carcinogenesis
Research offers insight into cellular biology of colorectal cancer
Kristi Neufeld has spent the better part of her career trying to understand the various activities of APC, a protein whose functional loss is thought to initiate roughly 80 percent of all colon polyps.
National Institutes of Health

Contact: Brendan M. Lynch
blynch@ku.edu
785-864-8855
University of Kansas

Public Release: 20-Aug-2014
JAMA Surgery
Patient perspectives on breast reconstruction following mastectomy
Less than 42 percent of women underwent breast reconstruction following a mastectomy for cancer, and the factors associated with foregoing reconstruction included being black, having a lower education level and being older.

Contact: Emily O'Donnell
odonnele@mskcc.org
212-639-6339
The JAMA Network Journals

Public Release: 20-Aug-2014
Science Translational Medicine
Treating gastric cancer -- with Botox
In an article published in the Aug. 20 edition of Science Translational Medicine, a team of international researchers reports that gastric cancer growth could be suppressed by eliminating the signals sent by nerves that are linked to cancer stem cells. The use of Botox to cut the connection between the nerves and the stem cells made the treatment cheap, safe and efficient.
Research Council of Norway, National Institutes of Health, Norwegian University of Science and Technology, St. Olavs University Hospital

Contact: Duan Chen
duan.chen@ntnu.no
47-984-09675
Norwegian University of Science and Technology

Public Release: 20-Aug-2014
JAMA Dermatology
Patient, tumor characteristics for high-mitotic rate melanoma
A study in Australia examined patient and tumor characteristics for melanomas with higher mitotic rates (a marker of tumor cell growth) in an effort to increase earlier detection of this aggressive cancer in patients.

Contact: Sarah Shen
sshenwq@gmail.com
The JAMA Network Journals

Public Release: 20-Aug-2014
Journal of Urology
Severe infections with hospitalization after prostate biopsy rising in Sweden
Transrectal ultrasound guided biopsy is the gold standard for detecting prostate cancer, but international reports have suggested that the number of risks associated with the procedure is increasing. In a new nationwide population-based study, Swedish researchers found that six percent of men filled a prescription for antibiotics for a urinary tract infection within 30 days after having a prostate biopsy, with a twofold increase in hospital admissions over five years, reports The Journal of Urology.

Contact: Linda Gruner
jumedia@elsevier.com
212-633-3923
Elsevier Health Sciences

Public Release: 20-Aug-2014
Science Translational Medicine
Severing nerves may shrink stomach cancers: Botox injections slow growth of tumors in mice
Research from Columbia University Medical Center shows that nerves may play a critical role in stomach cancer growth and that blocking nerve signals using surgery or Botox could be an effective treatment for the disease.
National Institutes of Health

Contact: Lucky Tran
lt2549@cumc.columbia.edu
212-305-3689
Columbia University Medical Center

Public Release: 20-Aug-2014
Cancer Cell
Blueprint for next generation of chronic myeloid leukemia treatment
Researchers at Huntsman Cancer Institute at the University of Utah have identified and characterized mutated forms of the gene that encodes BCR-ABL, the unregulated enzyme driving the blood cancer chronic myeloid leukemia.
NIH/National Cancer Institute, Howard Hughes Medical Institute, Huntsman Cancer Institute, Leukemia & Lymphoma Society, American Society of Hematology

Contact: Linda Aagard
801-587-7639
University of Utah Health Sciences

Public Release: 20-Aug-2014
Pigment Cell & Melanoma Research
Scientists learn more about rare skin cancer that killed Bob Marley
Acral melanomas, the rare type of skin cancer that caused Bob Marley's death, are genetically distinct from other types of skin cancer.
Cancer Research UK

Contact: Flora Malein
flora.malein@cancer.org.uk
44-020-346-96189
Cancer Research UK

Public Release: 19-Aug-2014
JAMA
Extended support helps patients stay smoke-free after hospital discharge
A Massachusetts General Hospital study in the Aug. 20 issue of JAMA describes a program that increased the proportion of hospitalized smokers who successfully quit smoking after discharge by more than 70 percent. The system used interactive voice response technology to provide support and stop-smoking medication for three months after smokers left the hospital.
National Institutes of Health

Contact: Terri Ogan
togan@partners.org
617-726-0954
Massachusetts General Hospital

Public Release: 19-Aug-2014
BJU International
Deaths rise with shift from in-hospital to outpatient procedures for urology surgeries
As hospitals have shifted an array of common urological surgeries from inpatient procedures to outpatient, potentially preventable deaths have increased following complications. Those were the primary findings of a new study led by Henry Ford Hospital researchers, who initially expected that improved mortality rates recently documented for surgery overall would also translate to commonly performed urologic surgeries. The opposite turned out to be true.

Contact: Dwight Angell
dwight.angell@hfhs.org
313-876-8709
Henry Ford Health System

Public Release: 19-Aug-2014
Leukemia
Natural (born) killer cells battle pediatric leukemia
Researchers at Children's Hospital Los Angeles have shown that a select team of immune-system cells can be multiplied in the lab, creating an army of natural killer cells that can be used to destroy leukemia cells.
Alex's Lemonade Stand Foundation, Leukemia & Lymphoma Society, V-Foundation

Contact: Ellin Kavanagh
ekavanagh@chla.usc.edu
Children's Hospital Los Angeles

Public Release: 19-Aug-2014
Proceedings of the National Academy of Sciences
Biomarker in an aggressive breast cancer is identified
Northwestern University scientists have identified a biomarker strongly associated with basal-like breast cancer, a highly aggressive carcinoma that is resistant to many types of chemotherapy. The biomarker, a protein called STAT3, provides a smart target for new therapeutics designed to treat this often deadly cancer. Using patient data from The Cancer Genome Atlas, the researchers used bioinformatics techniques and found that a small number of genes are activated by STAT3 protein signaling in basal-like breast cancers but not in luminal breast cancers.
H Foundation, NIH/National Cancer Institute

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University

Public Release: 19-Aug-2014
Neuro-Oncology
Markey researchers develop web-based app to predict glioma mutations
A new web-based program developed by University of Kentucky Markey Cancer Center researchers will provide a simple, free way for healthcare providers to determine which brain tumor cases require testing for a genetic mutation.
NIH/National Cancer Institute, Peter and Carmen Lucia Buck Training Program in Translational Clinical Oncology, University of Kentucky College of Medicine Physician Scientist Program

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky

Public Release: 19-Aug-2014
Journal of Clinical Investigation
Novel gene predicts both breast cancer relapse and response to chemotherapy
Scientists have made it easier to predict both breast cancer relapses and responses to chemotherapy, through the identification of a unique gene. The newly found marker could help doctors classify each breast cancer patient and customize a treatment regimen that is more effective. The discovery was a collaborative effort by scientists from A*STAR's Institute of Molecular and Cell Biology, and the Cancer Science Institute of Singapore at the National University of Singapore.

Contact: Tan Yun Yun
tan_yun_yun@a-star.edu.sg
65-682-66273
Biomedical Sciences Institutes (BMSI)

Public Release: 18-Aug-2014
Molecular Carcinogenesis
Leukemia drug shows promise for skin, breast and other cancers
A leukemia drug called dasatinib shows promise for treating skin, breast and several other cancers, according to researchers at Loyola University Chicago Stritch School of Medicine.

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System

Public Release: 18-Aug-2014
Nature Nanotechnology
MIPT and RAS scientists made an important step towards creating medical nanorobots
Researchers at Moscow Institute of Physics and Technology and Russian Academy of Sciences made an important step towards creating medical nanorobots discovering a way of enabling them to produce logical calculations using a variety of biochemical reactions.

Contact: Alexandra O. Borissova
borissova@phystech.edu
7-926-376-1175
Moscow Institute of Physics and Technology

Showing releases 1026-1050 out of 1182.

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