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Showing releases 1051-1075 out of 1312.

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Public Release: 9-Apr-2015
Journal of Pediatrics
A downward trend for new cases of pediatric melanoma
Melanoma is an aggressive form of skin cancer that has been increasing in incidence in adults over the past 40 years. Although pediatric melanoma is rare (5-6 children per million), most studies indicate that incidence has been increasing. In a new study scheduled for publication in The Journal of Pediatrics, researchers found that the incidence of pediatric melanoma in the United States actually has decreased from 2004-2010.

Contact: Becky Lindeman
journal.pediatrics@cchmc.org
513-636-7140
Elsevier Health Sciences

Public Release: 9-Apr-2015
Cell
A call to action for 2 cancer research fronts to join forces
Targeting the genetic drivers of cancer works in clinical trials, but cancers often resurface shortly thereafter. Immunotherapy -- which primes a patient's immune cells to attack tumors -- offers a longer-lasting response, but only in a fraction of people. The way forward, argue James P. Allison and Padmanee Sharma in a Review published April 9 in Cell, is to shift funding and research priorities so that these complementary approaches can be combined.

Contact: Joseph Caputo
jcaputo@cell.com
617-335-6270
Cell Press

Public Release: 9-Apr-2015
Cell
In the sea, a deadly form of leukemia is catching
Outbreaks of leukemia that have devastated some populations of soft-shell clams along the east coast of North America for decades can be explained by the spread of cancerous tumor cells from one clam to another. Researchers call the discovery, reported in the Cell Press journal Cell on April 9, 2015, 'beyond surprising.'
Howard Hughes Medical Institute, National Institutes of Health

Contact: Joseph Caputo
jcaputo@cell.com
617-335-6270
Cell Press

Public Release: 9-Apr-2015
Nature Communications
Epigenomic changes play an important role during the progression of melanoma
KU Leuven researchers have zeroed in on what makes cancer cells in melanoma so aggressive. They also succeeded in taming the effect in cell cultures. Melanoma, a type of skin cancer, is notoriously quick to metastasize and responds poorly to existing cancer treatments. In their study, published in Nature Communications, the researchers report a significant step forward in the characterization and potential treatment of melanoma.

Contact: Katrien Bollen
news@kuleuven.be
KU Leuven

Public Release: 9-Apr-2015
Environmental Health Perspectives
Increased levels of radon in Pennsylvania homes correspond to onset of fracking
Johns Hopkins Bloomberg School of Public Health researchers say that levels of radon in Pennsylvania homes -- where 42 percent of readings surpass what the US government considers safe -- have been on the rise since 2004, around the time that the fracking industry began drilling natural gas wells in the state.
NIH/National Institute of Environmental Health Sciences

Contact: Barbara Benham
bbenham1@jhu.edu
410-614-6029
Johns Hopkins University Bloomberg School of Public Health

Public Release: 9-Apr-2015
Cell
Stem cell disease model clarifies bone cancer trigger
Using induced pluripotent stem cells (iPSCs), a team led by Mount Sinai researchers has gained new insight into genetic changes that may turn a well known anti-cancer signaling gene into a driver of risk for bone cancers.
National Institutes of Health, Empire State Stem Cell Fund, University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund, National Breast Cancer Foundation

Contact: Renatt Brodsky
renatt.brodsky@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 9-Apr-2015
Cell Reports
Researchers find new approach to treat drug-resistant HER2-positive breast cancer
Resistance to therapy is a major problem in the cancer field. Even when a treatment initially works, the tumors often find ways around the therapy. Using human cell lines of the HER2-positive breast cancer subtype, researchers from the UNC School of Medicine and UNC Lineberger Comprehensive Cancer Center have detailed the surprising ways in which resistance manifests and how to defeat it before it happens.
National Institutes of Health, Susan G. Komen Foundation, University Cancer Research Fund at University of North Carolina at Chapel Hill

Contact: Mark Derewicz
mark.derewicz@unchealth.unc.edu
919-923-0959
University of North Carolina Health Care

Public Release: 9-Apr-2015
British Journal of Cancer
York scientists lead study on new treatment for prostate cancer
Scientists at the University of York have discovered a potential new treatment for prostate cancer using low temperature plasmas.
Engineering and Physical Sciences Research Council , Wellcome Trust, Yorkshire Cancer Research

Contact: Saskia Angenent
saskia.angenent@york.ac.uk
44-019-043-23918
University of York

Public Release: 9-Apr-2015
Nature Communications
UTSW researchers lead collaborative charge to uncover genetic diversity of pancreatic cancer
A genetic analysis led by UT Southwestern Medical Center researchers suggests that most pancreatic cancers harbor genetic alterations that could be targeted by existing drugs, using their genetic features as a roadmap for treatment. The findings support a precision approach to treating pancreatic cancer, the fourth most deadly cancer for both men and women.
NIH/National Cancer Institute, Cancer Prevention and Research Institute of Texas

Contact: Lori Sundeen Soderbergh
lori.soderbergh@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 9-Apr-2015
Molecular Cell
Study revises theory of how PTEN, a critical tumor suppressor, shuts off growth signals
From a team at CSHL, new evidence contradicting prior beliefs about how the protein PTEN -- one of the most important of the body's tumor suppressors -- works; specifically, how it is recruited to particular locations in our cells where pro-growth signals need to be shut off. It could help scientists design more effective drugs to counteract cancer's hallmark trait, uncontrolled cellular growth.
American Cancer Society, Pershing Square Sohn Foundation, US Department of Defense, National Institutes of Health, Robertson Research Fund of Cold Spring Harbor Laboratory

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Public Release: 9-Apr-2015
JAMA Oncology
Axillary lymph node evaluation performed frequently in ductal carcinoma in situ
Axillary lymph node evaluation is performed frequently in women with ductal carcinoma in situ breast cancer, despite recommendations generally against such an assessment procedure in women with localized cancer undergoing breast-conserving surgery, according to a study published online by JAMA Oncology.

Contact: Lucky Tran
lt2549@columbia.edu
212-305-3689
The JAMA Network Journals

Public Release: 8-Apr-2015
JAMA Surgery
MRI screening program for individuals at high risk of pancreatic cancer
A magnetic resonance imaging (MRI)-based screening program for individuals at high risk of pancreatic cancer identified pancreatic lesions in 16 of 40 (40 percent) of patients, of whom five underwent surgery, according to a report published online by JAMA Surgery.

Contact: Marco Del Chiaro, M.D., Ph.D.
marco.del-chiaro@karolinska.se
The JAMA Network Journals

Public Release: 8-Apr-2015
JAMA Dermatology
Melanoma surgery delays are common for Medicare patients
One in five Medicare patients with melanoma experience delays in getting surgery, a Yale study found.
Robert Wood Johnson Foundation, Yale Cancer Center/P30 Cancer Center Support Grant

Contact: Ziba Kashef
ziba.kashef@yale.edu
203-436-9317
Yale University

Public Release: 8-Apr-2015
JAMA Dermatology
Delay of surgery for melanoma common among Medicare patients
In a study that included more than 32,000 cases of melanoma among Medicare patients, approximately one in five experienced a delay of surgery that was longer than 1.5 months, and about 8 percent of patients waited longer than three months for surgery, according to an article published online by JAMA Dermatology.

Contact: Ziba Kashef
ziba.kashef@yale.edu
203-436-9317
The JAMA Network Journals

Public Release: 8-Apr-2015
Genome Medicine
We may be looking at wrong mutation for breast cancer treatment
A leading gene candidate that has been the target of breast cancer drug development may not be as promising as initially thought, according to research published in open-access journal Genome Medicine.

Contact: Shane Canning
shane.canning@biomedcentral.com
44-203-192-2243
BioMed Central

Public Release: 8-Apr-2015
Journal of the National Cancer Institute
Genetic screening could improve breast cancer prevention
A test for a wide range of genetic risk factors could improve doctors' ability to work out which women are at increased risk of developing breast cancer, a major study of more than 65,000 women has shown. Improving the accuracy of risk analysis using genetic screening could guide breast cancer prevention in several ways -- for instance by offering high-risk women increased monitoring, personalized advice and preventative therapies.
Cancer Research UK, European Union, Breakthrough Breast Cancer, National Institutes of Health

Contact: Henry French
henry.french@icr.ac.uk
020-715-35582
Institute of Cancer Research

Public Release: 8-Apr-2015
American Journal of Preventive Medicine
8 reasons the US Surgeon General should announce that UV tanning causes skin cancer
'In 1964 when the Surgeon General finally reported that smoking causes lung cancer, awareness and policy followed. Smoking rates declined and lung cancer rates have too. It's time for the Surgeon General to say the same thing about UV tanning,' says Robert P. Dellavalle, M.D., Ph.D., M.S.P.H., investigator at the CU Cancer Center.

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Anschutz Medical Campus

Public Release: 8-Apr-2015
Nature Cell Biology
Breast cancer research uncovers the fountain of youth
The Fountain of Youth has been discovered and it's not in Florida as Ponce de Leon claimed. Instead, it was found in the mammary glands of genetically modified mice. A research team led by professor Rama Khokha has found that when two factors that control tissue development are removed, you can avoid the impact of aging.

Contact: Liam Mitchell
liam.mitchell@utoronto.ca
416-978-4672
University of Toronto

Public Release: 8-Apr-2015
Nature
Biologists identify brain tumor weakness
A new discovery could offer more effective drugs to combat brain tumors.

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology

Public Release: 8-Apr-2015
Journal of Thoracic Oncology
No association between lung cancer risk in women and reproductive history or hormone use
The Women's Health Initiative Studies, a large prospective study of lung cancer, found no strong associations between lung cancer risk and a wide range of reproductive history variables and only revealed weak support for a role of hormone use in the incidence of lung cancer.

Contact: Murry Wynes
Murry.Wynes@iaslc.org
720-325-2945
International Association for the Study of Lung Cancer

Public Release: 8-Apr-2015
Nature Communications
A digital field guide to cancer cells
Scientists are mapping the habits of cancer cells, turn by microscopic turn. Using advanced technology and an approach that merges engineering and medicine, a Yale University-led team has compiled some of the most sophisticated data yet on the elaborate signaling networks directing highly invasive cancer cells. Think of it as a digital field guide for a deadly scourge.

Contact: Jim Shelton
james.shelton@yale.edu
203-432-3881
Yale University

Public Release: 8-Apr-2015
Nature
Tumor cells that mimic blood vessels could help breast cancer spread to other sites
A team of researchers from Cold Spring Harbor Laboratory and the Cancer Research UK Cambridge Institute at the University of Cambridge has shown in a mouse model that the ability of tumor cells to form tubular networks that mimic blood vessels can help drive metastasis, the spread of breast cancer to different sites in the body.
Howard Hughes Medical Institute, National Institutes of Health, Kathryn W. Davis, Hope Funds for Cancer Research, Boehringer Ingelheim Funds

Contact: Peter Tarr
tarr@cshl.edu
516-367-5055
Cold Spring Harbor Laboratory

Public Release: 8-Apr-2015
American Journal of Preventive Medicine
Researchers urge stronger warning for indoor tanning risks
The US Surgeon General should declare that indoor ultraviolet radiation tanning causes skin cancer, according to an article published today by the American Journal of Preventive Medicine. Robert P. Dellavalle, M.D., Ph.D., M.S.P.H., associate professor of dermatology at the University of Colorado School of Medicine, is the corresponding author of the article, which says there is enough evidence for the Surgeon General to clearly state that use of indoor tanning beds causes skin cancer.

Contact: Mark Couch
mark.couch@ucdenver.edu
303-724-5377
University of Colorado Anschutz Medical Campus

Public Release: 7-Apr-2015
Stem Cells
Moffitt researchers discover novel mechanism controlling lung cancer stem cell growth
Moffitt Cancer Center researchers discovered a novel mechanism that plays an important role in the maintenance of lung cancer stem cells. This finding may lead to new potential therapeutic targets.
National Institutes of Health

Contact: Kim Polacek
Kim.Polacek@Moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 7-Apr-2015
Human Genome Variation
A better biomarker to predict cetuximab response in CRC patients
Scientists at Insilico Medicine Inc. and Champions Oncology Inc. have successfully demonstrated a method to predict response to cetuximab in patients with colorectal cancer using OncoFinder pathway activation strength. The study identified a novel prognostic marker in colorectal cancer treated with cetuximab.

Contact: Qingsong Zhu
zhu@insilicomedicine.com
410-710-9674
InSilico Medicine, Inc.

Showing releases 1051-1075 out of 1312.

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