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Showing releases 1051-1075 out of 1352.

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Public Release: 15-Feb-2016
Nature Genetics
Discovery lays the foundation to expand personalized chemotherapy for leukemia patients
St. Jude Children's Research Hospital scientists lead a study of how inherited genetic variations in the NUDT15 gene cause serious chemotherapy toxicity; findings point to potential genetics-guided precision medicine.
US National Institutes of Health, Order of St. Francis Foundation, V Foundation for Cancer Research, Danish Childhood Cancer Foundation, Japanese Ministry of Health, National Medical Research Council, Singapore, Children's Cancer

Contact: Frannie Marmorstein
St. Jude Children's Research Hospital

Public Release: 15-Feb-2016
Nano Letters
Light used to measure the 'big stretch' in spider silk proteins
While working to improve a tool that measures the pushes and pulls sensed by proteins in living cells, biophysicists at Johns Hopkins say they've discovered one reason spiders' silk is so elastic: Pieces of the silk's protein threads act like supersprings, stretching to five times their initial length. The investigators say the tool will shed light on many biological events, including the shifting forces between cells during cancer metastasis.
National Science Foundation Physics Frontier Centers, NIh/National Institute of General Medical Sciences , NIh/National Institute of Diabetes and Digestive and Kidney Diseases, American Heart Association

Contact: Catherine Gara
Johns Hopkins Medicine

Public Release: 14-Feb-2016
2016 AAAS Annual Meeting
Dr. Stan Riddell, an innovator in cancer immunotherapy at Fred Hutch, to present at AAAS annual meeting
Dr. Stanley Riddell, an immunotherapy researcher and oncologist at Seattle's Fred Hutchinson Cancer Research Center, will present an update on new adoptive T-cell strategies for cancer at the AAAS annual meeting Feb. 14. His presentation will be part of a symposium on the promise and progress of T-cell therapy to fight human diseases. For more than 25 years, Riddell has pioneered experimental therapies that modify and empower the immune system to effectively treat cancers and infectious diseases.
Juno Therapeutics

Contact: Sandy Van
Fred Hutchinson Cancer Research Center

Public Release: 14-Feb-2016
Stem Cell Reports
Making cancer-fighting cells in the lab
Scientists reprogram human invariant natural killer T cells to induced pluripotent stem cells, which were then differentiated back to iNKT cells that showed stronger activity than the original iNKT cells. This study shows iPS cell technology can be used to recover immune cells that have weakened immune activity.
Japanese Ministry of Education, Culture, Sports, Science and Technology, Aichi Cancer Research Foundation, Takeda Science Foundation, The National Cancer Center Research and Development Fund, Daiwa Securities Health Foundation

Contact: Peter Karagiannis
Center for iPS Cell Research and Application - Kyoto University

Public Release: 14-Feb-2016
2016 AAAS Annual Meeting
Progress in fighting cancer and infections with T cell therapy
The quest to bring immunotherapy into widespread clinical use against cancer and infectious diseases has made great strides in recent years. For example, clinical trials of adoptive T cell therapy are yielding highly promising results. The latest progress is being reported at AAAS 2016 by three international leaders in the field: Professor Dirk Busch, Technical University of Munich; Professor Chiara Bonini, San Raffaele Scientific Institute; and Professor Stanley Riddell, Fred Hutchinson Cancer Research Center.
German Research Foundation, Institute of Advanced Study, Juno Therapeutics

Contact: Patrick Regan
Technical University of Munich (TUM)

Public Release: 12-Feb-2016
Nature Communications
Gene previously observed only in brain is important driver of metastatic breast cancer
Scientists from The Wistar Institute have shown that one gene that was once thought only to be found in the brain is also expressed in breast cancer and helps promote the growth and spread of the disease. Additionally, they showed how a version of the gene with edited RNA prevents metastasis.
National Institutes of Health, Doctors Cancer Foundation, Breast Cancer Alliance, W. W. Smith Foundation, Edward Mallinckrodt Jr. Foundation, ACS-IRG, National Natural Science Funds, Macular Vision Research Foundation

Contact: Ben Leach
The Wistar Institute

Public Release: 12-Feb-2016
PLOS Genetics
Genome studies can help identify lifestyle risks for diseases
A type of study commonly used to pinpoint genetic variants associated with diseases can also be used to identify the lifestyle predictors that increase the risk of a disease -- something that is often overlooked in genetic studies

Contact: Simon Davies
University of Bristol

Public Release: 12-Feb-2016
Nano Letters
New nanotechnology detects biomarkers of cancer
Researchers at Wake Forest Baptist Medical Center have developed a new technology to detect disease biomarkers in the form of nucleic acids, the building blocks of all living organisms.
National Institutes of Health, The Dr. Arthur and Bonnie Ennis Foundation, 3M Non-tenured Faculty Award

Contact: Marguerite Beck
Wake Forest Baptist Medical Center

Public Release: 12-Feb-2016
Clinical Cancer Research
Study finds mechanism by which obesity promotes pancreatic and breast cancer
Massachusetts General Hospital investigators may have uncovered a novel mechanism behind the ability of obesity to promote cancer progression.
National Institutes of Health, US Department of Defense, Lustgarten Foundation, Warshaw Institute for Pancreatic Cancer Research, Foundation for Science and Technology of Portugal

Contact: Katie Marquedant
Massachusetts General Hospital

Public Release: 11-Feb-2016
JAMA Oncology
New test could help select the best treatment for bowel cancer patients
A new test could help patients with advanced bowel cancer get the best treatment for their disease, according to a Cancer Research UK clinical trial published today in JAMA Oncology.

Contact: Emily Head
Cancer Research UK

Public Release: 11-Feb-2016
Journal of Breath Research
New milestone for device that can 'smell' prostate cancer
A research team from the University of Liverpool has reached an important milestone towards creating a urine diagnostic test for prostate cancer that could mean that invasive diagnostic procedures that men currently undergo eventually become a thing of the past.

Contact: Simon Wood
University of Liverpool

Public Release: 11-Feb-2016
Cell Reports
How a master regulator in ovarian cancer can go from helpful to harmful
Scientists at The Wistar Institute have defined the role of how a master genomic organizer influences the behavior of these ovarian-associated dendritic cells, revealing a previously unseen way in which cancer is able to manipulate our immune system. Study results were published in the journal Cell Reports.
National Institutes of Health, US Department of Defense, Jayne Koskinas and Ted Giovanis Breast Cancer Research Consortium at Wistar, Ovarian Cancer Research Fund

Contact: Ben Leach
The Wistar Institute

Public Release: 11-Feb-2016
PLOS Pathogens
Adenovirus dampens host DNA damage response -- implications for control and cancer therapy
Adenoviruses (Ad) are everywhere, and while they pose limited threat in individuals with healthy immune systems, they cause significant disease burden in immunocompromised patients. A study published on Feb. 11 in PLOS Pathogens reports on a new mechanism by which the virus interferes with the host's ability to detect and eliminate viral intruders.

Contact: Tamar Kleinberger

Public Release: 11-Feb-2016
Alternative proteins encoded by the same gene have widely divergent functions in cells
In a first large-scale systematic study, researchers at Dana-Farber Cancer Institute, University of California, San Diego School of Medicine, and McGill University found that most sibling proteins -- known as 'protein isoform' encoded by the same gene -- often play radically different roles within tissues and cells, however alike they may be structurally.
National Human Genome Research Institute, Ellison Foundation, NIH/National Cancer Institute, Krembil Foundation, Canada Excellence Research Chair Award, Ontario Research Fund-Research

Contact: Anne Doerr
Dana-Farber Cancer Institute

Public Release: 11-Feb-2016
JAMA Oncology
Increasing BRCA testing rates in young women with breast cancer
Rates of genetic testing for BRCA1 and BRCA2 mutations have increased among women diagnosed with breast cancer at age 40 or younger, according to an article published online by JAMA Oncology.

Contact: John Noble
The JAMA Network Journals

Public Release: 11-Feb-2016
Science Translational Medicine
Younger T cells may improve immunotherapy for children's cancer
Pediatric oncologists have investigated techniques to improve and broaden a novel personalized cell therapy to treat children with cancer. The researchers say a patient's outcome may be improved if clinicians select specific subtypes of T cells to attack diseases like acute lymphoblastic leukemia and lymphoma.
Leukemia and Lymphoma Society, Weinberg Funds, Cookies for Kids' Cancer, Stand Up to Cancer-St. Baldrick's Pediatric Dream Team Translational Research Grant

Contact: John Ascenzi
Children's Hospital of Philadelphia

Public Release: 11-Feb-2016
Breakable genes may promote disease and brain cell diversity
Howard Hughes Medical Institute (HHMI) researchers have identified 27 genes in brain stem cells that are prone to a type of DNA damage. The fragility of those genes could explain why they are often mutated or deleted in cancers and neuropsychiatric disorders such as schizophrenia. But their tendency to break could also benefit the brain by providing a way to produce a greater diversity of neurons.

Contact: Jim Keeley
Howard Hughes Medical Institute

Public Release: 11-Feb-2016
JAMA Oncology
JAMA Oncology: An expert opinion on how to address the skyrocketing prices of cancer drugs
Many patients with cancer find themselves in great financial distress, in part because the costs of cancer-fighting drugs are skyrocketing. Is it possible to create public policy that will rein in these prices and cut patients' out-of-pocket costs? Not without significant tradeoffs that could reduce patients' access to some cancer medications, says physician, cancer researcher and health economist Dr. Scott Ramsey in a JAMA Oncology editorial.

Contact: Sandy Van
Fred Hutchinson Cancer Research Center

Public Release: 11-Feb-2016
Nature Medicine
The CNIO finds a potential therapy for the most aggressive type of lung cancer in preclinical models
The specific combination of the drugs dasatinib and demcizumab impairs the growth of KRAS-driven lung tumors, the most aggressive sub-type and with the lowest survival rates. The research was conducted on mouse models and samples of human tumors. The experts are confident they can soon start clinical trials which will make it possible to transfer the discoveries to cancer patients. The results will be made public this week in 'Nature Medicine.'

Contact: Vanessa Pombo
Centro Nacional de Investigaciones Oncológicas (CNIO)

Public Release: 11-Feb-2016
Scientific Reports
Plant extract shows promise in treating pancreatic cancer
A natural extract derived from India's neem tree could potentially be used to treat pancreatic cancer, according to a new study in the journal Scientific Reports.

Contact: Veronique Masterson
Texas Tech University Health Sciences Center El Paso

Public Release: 11-Feb-2016
DNA breaks in nerve cells' ancestors cluster in specific genes
Study reveals new avenue for thinking about brain development, brain tumors and neurodevelopmental/psychiatric diseases.

Contact: Kristen Dattoli
Boston Children's Hospital

Public Release: 11-Feb-2016
2016 AAAS Annual Meeting
Put that in your e-cigarette and smoke it, or should you?
Ilona Jaspers, Ph.D., from the UNC School of Medicine, recently completed research showing how the chemicals in e-cigarettes can change immune responses in our airways. She will present her findings at the AAAS annual meeting Feb. 11-16.

Contact: Mark Derewicz
University of North Carolina Health Care

Public Release: 10-Feb-2016
JAMA Oncology
Research uncovers more inherited genetic mutations linked to ovarian cancer
Previous research has established a link between genetic mutations in the BRCA1 and BRCA2 genes to an increased risk of developing ovarian, fallopian tube or peritoneal cancer in women. A recent publication documents the efforts of a team of researchers affiliated with the Gynecologic Oncology Group (GOG) to determine if inherited genetic mutations other than BRCA1 and BRCA2 can also put a woman at risk of developing these diseases.

Contact: Susan McDonald
Care New England

Public Release: 10-Feb-2016
Proceedings of the National Academy of Sciences
Scientists find leukemia's surroundings key to its growth
Researchers at The University of Texas at Austin have discovered that a type of cancer found primarily in children can grow only when signaled to do so by other nearby cells that are noncancerous.
Cancer Prevention and Research Institute of Texas, American Cancer Society, NIH/Intramural Research Program

Contact: Christine Sinatra
University of Texas at Austin

Public Release: 10-Feb-2016
Prostate cancer survivors' risk of heart disease studied
Vanderbilt's Cardio-oncology program is focusing on modulating the risk factors for cardiovascular disease in men, especially those receiving androgen deprivation therapy (ADT) to treat their prostate cancer.

Contact: Craig Boerner
Vanderbilt University Medical Center

Showing releases 1051-1075 out of 1352.

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