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Showing releases 1076-1100 out of 1249.

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Public Release: 29-May-2014
Cancer Cell
Melanoma of the eye caused by 2 gene mutations
Researchers at the University of California, San Diego School of Medicine have identified a therapeutic target for treating the most common form of eye cancer in adults. They have also, in experiments with mice, been able to slow eye tumor growth with an existing FDA-approved drug.
National Institutes of Health, California Institute for Regenerative Medicine

Contact: Scott LaFee
University of California - San Diego

Public Release: 28-May-2014
New England Journal of Medicine
Tiny mutation triggers drug resistance for patients with one type of leukemia
Researchers have pinpointed exactly what goes wrong when chronic lymphocytic leukemia patients develop resistance to ibrutinib, a highly effective, precisely targeted anti-cancer drug. The finding could guide development of new agents to treat drug-resistant disease.
Leukemia and Lymphoma Society, Prince Family Foundation

Contact: John Easton
University of Chicago Medical Center

Public Release: 28-May-2014
Science Translational Medicine
T cell repertoire changes predictive of anti-CTLA-4 cancer immunotherapy outcome revealed
Sequenta Inc. today announced publication of a study that used the company's proprietary LymphoSIGHT immune repertoire sequencing platform to investigate the effects of anti-CTLA-4 antibody on the number and types of T cells present in a patient's blood. The results shed light on the mechanism of action of this type of cancer immunotherapy and suggest that immune repertoire sequencing could be used to predict which patients will have improved survival in response to treatment.

Contact: Erin Davis
Sequenta Inc.

Public Release: 28-May-2014
Journal of the National Cancer Institute
The scarier the better -- screening results that make smokers stop smoking
Screening for lung cancer leads to early detection and treatment, but can it also make people stop smoking before they get cancer? The answer is that it depends on the seriousness of the results, according to a study published May 28 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
Oxford University Press USA

Public Release: 28-May-2014
'Nanodaisies' deliver drug cocktail to cancer cells
Biomedical engineering researchers have developed daisy-shaped, nanoscale structures that are made predominantly of anti-cancer drugs and are capable of introducing a 'cocktail' of multiple drugs into cancer cells.
National Institutes of Health

Contact: Matt Shipman
North Carolina State University

Public Release: 28-May-2014
Journal of the National Cancer Institute
Indoor tanning, even without burning, increases the risk of melanoma
People sometimes use indoor tanning in the belief that this will prevent burns when they tan outdoors. However, indoor tanning raises the risk of developing melanoma even if a person has never had burns from either indoor or outdoor tanning, according to a study published May 29 in the Journal of the National Cancer Institute.

Contact: Zachary Rathner
Oxford University Press USA

Public Release: 28-May-2014
Major discovery on the mechanism of drug resistance in leukemia and other cancers
A mechanism that enables the development of resistance to acute myeloid leukemia anticancer drugs, thereby leading to relapse, has been identified by Kathy Borden of the University of Montreal's Institute for Research in Immunology and Cancer and her collaborators.
National Institutes of Health, Leukemia and Lymphoma Society, Pharmascience Inc., IRICoR, Cancer Research Chairs, Natural Sciences and Engineering Research Council of Canada

Contact: William Raillant-Clark
University of Montreal

Public Release: 28-May-2014
Annals of Surgical Oncology
NYU researchers pilot educational and behavioral program to reduce lymphedema risk
NYU researchers conducted a pilot study to evaluate a patient-centered educational and behavioral self-care program called The Optimal Lymph Flow. The goals of the program were to promote lymph flow and optimize BMI over a 12-month period after breast cancer surgery. Findings offer initial evidence in support of a shift in the focus of lymphedema care away from treatment and toward proactive risk reduction.
Avon Foundation, NIH/National Cancer Institute

Contact: christopher james
New York University

Public Release: 28-May-2014
BIO International Convention
Artificial lung the size of a sugar cube
What medications can be used to treat lung cancer, and how effective are they? Until now, drug companies have had to rely on animal testing to find out. But in the future, a new 3-D model lung is set to achieve more precise results and ultimately minimize -- or even completely replace -- animal testing. From June 23-26, researchers will be presenting their new model at the BIO International Convention in San Diego, Calif.

Contact: Dr. Heike Walles

Public Release: 28-May-2014
Journal of Urology
Study affirms value of epigenetic test for markers of prostate cancer
A multicenter team of researchers report that a commercial test designed to rule out the presence of genetic biomarkers of prostate cancer may be accurate enough to exclude the need for repeat prostate biopsies in many -- if not most -- men.

Contact: Stephanie Desmon
Johns Hopkins Medicine

Public Release: 28-May-2014
Cancer Cell
International collaboration highlights new mechanism explaining how cancer cells spread
UT Southwestern Medical Center cancer researchers have identified a protein critical to the spread of deadly cancer cells and determined how it works, paving the way for potential use in diagnosis and eventually possible therapeutic drugs to halt or slow the spread of cancer.
National Institutes of Health, China Postdoctoral Science Foundation

Contact: Russell Rian
UT Southwestern Medical Center

Public Release: 28-May-2014
MRI catches breast cancer early in at-risk survivors of childhood Hodgkin lymphoma
The largest clinical study to evaluate breast cancer screening of female survivors of childhood Hodgkin lymphoma, who are at increased risk because they received chest radiation, shows that magnetic-resonance imaging detected invasive breast tumors at very early stages, when cure rates are expected to be excellent.

Contact: Jane Finlayson
University Health Network

Public Release: 27-May-2014
Proceedings of the National Academy of Sciences
Two new possible drug targets for triple negative breast cancer
The suppression of two genes reduce breast cancer tumor formation and metastasis by interfering with blood vessel formation and recruitment, report scientists in the Proceedings of the National Academy of Sciences. The findings may help medical researchers identify effective drug targets for triple negative breast cancer, or TNBC.
National Institutes of Health, Golfers Against Cancer, Breast Cancer Research Foundation

Contact: David Bricker
Houston Methodist

Public Release: 27-May-2014
EMBO Molecular Medicine
Researchers identify a new suppressor of breast metastasis to the lung
The research headed by Roger Gomis at IRB Barcelona, with the collaboration of Joan Massagué, describes that the loss of the suppressor RARRES3 promotes the colonization of breast cancer cells in the lung. RARRES3 could prove to be a useful marker to identify patients with a greater risk of metastasis, as well as providing a target for the development of a specific treatment for preventive strategies after removal of the primary tumor.
BBVA Foundation, Asociación Española Contra el Cáncer, Generalitat de Catalunya, gobierno de España

Contact: Sònia Armengou
Institute for Research in Biomedicine (IRB Barcelona)

Public Release: 27-May-2014
Cell Reports
New jigsaw piece for the repair of DNA crosslinks
DNA damage repair is highly complex. UZH researchers have now discovered another piece in the puzzle for the removal of extremely dangerous DNA lesions. Faithful and efficient repair of so-called crosslinks requires a collaboration between a specific signalling and repair protein. As crosslink-inducing agents are used in chemotherapy, the new insights are also important for the development of better anti-cancer treatment strategies.

Contact: Dr. Alessandro A. Sartori
University of Zurich

Public Release: 27-May-2014
Annals of Allergy, Asthma & Immunology
E-cigarettes: Not a healthy alternative to smoking
A new study examines the risks of e-cigarettes.

Contact: Hollis Heavenrich-Jones
American College of Allergy, Asthma, and Immunology

Public Release: 27-May-2014
Journal of Clinical Oncology
Study identifies risk of chemotherapy related hospitalization for eary-stage breast cancer patients
Oncologists now have a new understanding of the toxicity levels of specific chemotherapy regimens used for women with early stage breast cancer, according to research from The University of Texas MD Anderson Cancer Center.

Contact: Laura Sussman
University of Texas M. D. Anderson Cancer Center

Public Release: 27-May-2014
An area's level of poverty or wealth may affect the distribution of cancer types
A new analysis has found that certain cancers are more concentrated in areas with high poverty, while other cancers arise more often in wealthy regions.

Contact: Evelyn Martinez

Public Release: 27-May-2014
Journal of Clinical Investigation
JCI online ahead of print table of contents for May 27, 2014
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers published online, May 27, 2014, in the JCI: 'Disturbed blood flow induces epigenetic alterations to promote atherosclerosis,' 'Protecting dopaminergic neurons from Parkinson's disease-associated degradation,' 'Splicing regulator SLU7 is essential for maintaining liver homeostasis,' 'Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression,' 'WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors,' and more.

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 27-May-2014
American Urological Association Annual Conference
Vanderbilt study finds women referred for bladder cancer less often than men
Women with blood in their urine were less than half as likely as men with the same issue to be referred to a urologist for further tests, according to a new Vanderbilt University study.
National Cancer Institute

Contact: Craig Boerner
Vanderbilt University Medical Center

Public Release: 27-May-2014
Cancer, bioelectrical signals and the microbiome connected
Bioelectrical signals from distant cells control the incidence of tumors arising from cancer-causing genes in tadpoles, and this process is impacted by levels of a common fatty acid produced by bacteria in the tadpole and also in humans. This research has important implications for preventing, diagnosing and treating cancer, and for understanding the role of genetics and physiology in oncology.
G. Harold and Leila Y. Mathers Charitable Foundation, Defense Advanced Research Projects Agency

Contact: Kim Thurler
Tufts University

Public Release: 27-May-2014
Medical Care
More access to health care may lead to unnecessary mammograms
Researchers have concluded that providing better access to health care may lead to the overuse of mammograms for women who regularly see a primary care physician and who have a limited life expectancy. The cautionary note from researchers at the University of Texas Medical Branch at Galveston is that screening women in this category could subject them 'to greater risks of physical, emotional and economic suffering.'
Cancer Prevention Research Institute of Texas, National Institutes of Health

Contact: Raul Reyes
University of Texas Medical Branch at Galveston

Public Release: 27-May-2014
New University of Colorado study illuminates how cancer-killing gene may actually work
Scientists armed with a supercomputer and a vast trove of newly collected data on the body's most potent "tumor suppressor" gene have created the best map yet of how the gene works, an accomplishment that could lead to new techniques for fighting cancers, which are adept at disabling the gene in order to thrive.
Howard Hughes Medical Institute, National Institutes of Health, National Science Foundation

Contact: Garth Sundem
University of Colorado Denver

Public Release: 27-May-2014
Developmental Cell
UCI researchers identify new functional roles on cell surfaces for estrogen
A discovery by UC Irvine endocrinologists about the importance of cell surface receptors for estrogen has the potential to change how researchers view the hormone's role in normal organ development and function.
National Institutes of Health, Department of Veterans Affairs

Contact: Tom Vasich
University of California - Irvine

Public Release: 26-May-2014
A novel disease-preventing antioxidant pathway
A team in Singapore has recently showed that uric acid is a major intracellular antioxidant, possibly even more important than the antioxidants we try to eat. They also discovered how uric acid helps to prevent aging and disease and how it helps in the treatment of cancer.
Singapore Ministry of Education

Contact: Dharshini Subbiah
Duke-NUS Graduate Medical School Singapore

Showing releases 1076-1100 out of 1249.

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