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Showing releases 1076-1100 out of 1304.

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Public Release: 17-Sep-2015
Cell
Digital 'Rosetta Stone' decrypts how mutations rewire cancer cells
Scientists have discovered how genetic cancer mutations systematically attack the networks controlling human cells, knowledge critical for the future development of personalized precision cancer treatments.
Lundbeck Foundation, European Research Council, Villum Kann Rasmussen Foundation, Novo Nordisk Foundation, National Institute of Health, Ludwig Foundation

Contact: Rune Linding
linding@lindinglab.org
452-365-1941
University of Copenhagen, Biotech Research & Innovation Centre

Public Release: 17-Sep-2015
Molecular Cell
Temple University School of Medicine scientists identify protein at death's door of cells
A protein embedded in the surface of mitochondria -- the energy-producing batteries of living cells -- opens the door to cell death, causing cells to experience severe power failures, according to researchers at Temple University School of Medicine. The new study, published September 17 by Molecular Cell, suggests that blocking the door with a small molecule inhibitor could be key to the treatment of cardiovascular diseases where extensive mitochondrial dysfunction and cell death hinder tissue recovery.
National Institutes of Health

Contact: Jeremy Walter
Jeremy.Walter@tuhs.temple.edu
267-838-0398
Temple University Health System

Public Release: 17-Sep-2015
Clinical Epigenetics
Research discovery leads to potential diagnostic for assessing breast cancer recurrence
Every woman successfully treated for breast cancer lives with the knowledge that it could come back. New research published today in the journal Clinical Epigenetics may lead to a simple blood test to determine the risk of such recurrence, or the cancer invading other organs such as the lungs, bone or brain. Such a test would have profound implications for improving the future treatment of women with all types of breast cancer.
Marilyn B. Gula Mountains of Hope Foundation and SmartPractice

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute

Public Release: 17-Sep-2015
Cell Metabolism
Cancer doesn't sleep: Myc oncogene disrupts clock and metabolism in cancer cells
Myc is a cancer-causing gene responsible for disrupting the normal 24-hour internal rhythm and metabolic pathways in cancer cells. The researchers found that MYC protein may affect circadian rhythm and metabolism by promiscuously binding to promoter regions in key genes for maintaining these daily cycles.
NIH/National Cancer Institute, Leukemia and Lymphoma Society, Abramson Family Cancer Research Institute

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 17-Sep-2015
Cell Reports
New approach found to tackle breast cancer hormone therapy resistance
University of Manchester researchers funded by Breast Cancer Now have discovered a new explanation as to why women with oestrogen receptor positive (ER+) breast cancer develop resistance to hormone treatment, and a potential new approach to overcome the problem.
ASDA's Tickled Pink/Breast Cancer Now Fellowship, The Zochonis Trust, and others

Contact: Jamie Brown
jamie.brown@manchester.ac.uk
44-016-127-58383
University of Manchester

Public Release: 17-Sep-2015
American Journal of Epidemiology
Study of leukemias in children living close to heavily used roads
Inserm researchers from CRESS studied the risk of acute leukemia in children living close to heavily used roads. The results show that the incidence of new cases of myeloblastic leukemia (418 of 2,760 cases of leukemia) was 30 percent higher in children in the population whose residence was located within 150 m of heavily used roads, and had a combined length of over 260 m within this radius.

Contact: Jacqueline Clavel
jacqueline.clavel@inserm.fr
INSERM (Institut national de la santé et de la recherche médicale)

Public Release: 17-Sep-2015
Surgical Clinics of North America
New prostate cancer screening review article advocates for active surveillance
In the wake of changing guidelines related to prostate cancer screening, a newly published review article out of University Hospitals Case Medical Center's Seidman Cancer Center in Cleveland provides important guidance about the prostate specific antigen test. The peer-reviewed article, titled Prostate Cancer Screening and the Associated Controversy, was published in the October issue of Surgical Clinics of North America.

Contact: Alicia Reale
alicia.reale@uhhospitals.org
University Hospitals Case Medical Center

Public Release: 17-Sep-2015
The Breast
Study finds high proportion of advanced breast cancers in sub-Saharan Africa
In one of the first studies of its kind, a new report finds a large majority of breast cancers in Cote d'Ivoire and Republic of Congo are detected only after they've become advanced.
The African Cancer Registry Network

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society

Public Release: 17-Sep-2015
International Journal of Cancer
Biomarker may predict who'll benefit from targeted therapy for HER2-negative breast cancer
A multi-center team led by Case Western Reserve has demonstrated that brief exposure to a targeted therapy can tell doctors which HER2-negative patients will respond -- and which should switch to another kind of treatment. Their findings appear in this month's International Journal of Cancer.
Abraxis BioScience, Inc., Philips Research, and Breast Cancer Research Foundation

Contact: Jeannette Spalding
jeannette.spalding@case.edu
216-368-3004
Case Western Reserve University

Public Release: 16-Sep-2015
Lancet Haematology
Multiple myeloma patients vulnerable to 'financial toxicity,' due to costly treatments
Even patients with health insurance who have multiple myeloma may be vulnerable to 'financial toxicity' -- including those who make over $100,000 a year -- because of the higher use of novel therapeutics and extended duration of myeloma treatment, researchers from Penn's Abramson Cancer Center report in this week's Lancet Haematology.

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-301-5221
University of Pennsylvania School of Medicine

Public Release: 16-Sep-2015
AACR International Cancer Immunotherapy Conference
Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma
Mayo Clinic researchers have identified a protein marker whose frequency may predict patient response to PD-1 blockade immunotherapy for melanoma. An abstract of their findings was presented today at the American Association for Cancer Research International Cancer Immunotherapy Conference in New York City.

Contact: Joe Dangor
newsbureau@mayo.edu
507-284-5005
Mayo Clinic

Public Release: 16-Sep-2015
CA: A Cancer Journal for Clinicians
Report: Cancer remains leading cause of death in US Hispanics
While cancer is the second leading cause of death overall in the United States, it remains the leading cause of death among US Hispanics, according to an American Cancer Society report.
American Cancer Society

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society

Public Release: 16-Sep-2015
Journal of National Cancer Institute
IRB Barcelona identifies the gene responsible for metastasis of breast cancer to the bone
Physicians currently have no tools to help them detect which breast cancer patients will suffer metastasis to the bone, a process that occurs in 15-20 percent of cases. A study led by ICREA researcher Roger Gomis at the Institute for Research in Biomedicine and published today in JNCI has uncovered a gene that allows breast cancer cells to invade bones and create new tumors, or to metastasize.

Contact: Sonia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)

Public Release: 16-Sep-2015
ACS Nano
New approach to mammograms could improve reliability
Detecting breast cancer in women with dense mammary tissues could become more reliable with a new mammogram procedure that researchers have now tested in pre-clinical studies of mice. In their report in the journal ACS Nano, they describe injecting gold nanoparticles in mammary tissue to enhance the imaging of early signs of breast cancer.

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

Public Release: 16-Sep-2015
CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference
Penn team pinpoints immune changes in blood of melanoma patients on PD-1 drugs
A simple blood test can detect early markers of 'reinvigorated' T cells and track immune responses in metastatic melanoma patients after initial treatment with the anti-PD-1 drug pembrolizumab, researchers from the Abramson Cancer Center of the University of Pennsylvania report in new research being presented at the inaugural CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference.
National Institutes of Health, Merck

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-301-5221
University of Pennsylvania School of Medicine

Public Release: 16-Sep-2015
Current Opinion in Chemical Biology
Synthetic biology needs robust safety mechanisms before real world application
Targeted cancer treatments, toxicity sensors and living factories: synthetic biology has the potential to revolutionize science and medicine. But before the technology is ready for real-world applications, more attention needs to be paid to its safety and stability, say experts in a review article published in Current Opinion in Chemical Biology.

Contact: Aileen Christensen
a.christensen@elsevier.com
31-204-852-053
Elsevier

Public Release: 16-Sep-2015
Journal of Proteome Research
Researchers isolate possible ovarian cancer biomarkers
Researchers from North Carolina State University utilized a highly sensitive mass spectrometry analysis to identify and measure difficult-to-detect N-glycan biomarkers associated with ovarian cancers in stages I-IV. In a surprising finding, the researchers determined that the level of biomarkers associated with ovarian cancer does not simply increase or decrease over the course of the disease, but can rise and fall during different stages.

Contact: Tracey Peake
tracey_peake@ncsu.edu
919-515-6142
North Carolina State University

Public Release: 16-Sep-2015
Cancer Research
Surgical probe seeks out where cancer ends and healthy tissue begins
A new surgical tool that uses light to make sure surgeons removing cancerous tumors 'got it all' was found to correlate well with traditional pathologists' diagnoses in a clinical study, showing that the tool could soon enable reliable, real-time guidance for surgeons.
National Institutes of Health

Contact: Liz Ahlberg
eahlberg@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign

Public Release: 16-Sep-2015
Frontiers in Psychology
Immune system may be pathway between nature and good health
Research has found evidence that spending time in nature provides protections against a startling range of diseases, including depression, diabetes, obesity, ADHD, cardiovascular disease, cancer, and many more. How this exposure to green space leads to better health has remained a mystery. After reviewing hundreds of studies examining nature's effects on health, University of Illinois environment and behavior researcher Ming Kuo believes the answer lies in nature's ability to enhance the functioning of the body's immune system.

Contact: Debra Levey Larson
dlarson@illinois.edu
217-244-2880
University of Illinois College of Agricultural, Consumer and Environmental Sciences

Public Release: 16-Sep-2015
ACS Nano
New catalyst yields more accurate PSA test
A research team led by Michigan Tech chemist Xiaohu Xia developed a catalyst that improves the sensitivity of the standard PSA test over 100-fold. The catalyst is made of palladium nanocubes coated with iridium.
Michigan Technological University, Louisiana State University, Oak Ridge National Laboratory, American Chemical Society Petroleum Research Fund and DOE Office of Science User Facility/Center for Nanophase Materials Sciences

Contact: Xiaohu Xia
xiaxh@mtu.edu
906-487-2048
Michigan Technological University

Public Release: 15-Sep-2015
FASEB Journal
Research breakthrough in fight against muscle wasting diseases
It is estimated that half of all cancer patients suffer from a muscle wasting syndrome called cachexia. Cancer cachexia impairs quality of life and response to therapy, which increases morbidity and mortality of cancer patients. Currently, there is no approved treatment for muscle wasting but a new study from the Research Institute of the MUHC and University of Alberta could be a game changer for patients, improving both quality of life and longevity.
Canadian Institutes of Health Research, Terry Fox Research Institute

Contact: Julie Robert
julie.robert@muhc.mcgill.ca
514-934-1934 x71381
McGill University Health Centre

Public Release: 15-Sep-2015
eLife
New drugs could stop the growth of drug-resistant childhood tumors
New drugs are needed to treat the most common type of childhood brain tumor and could also be effective against skin cancer.

Contact: Zoe Dunford
z.dunford@elifesciences.org
44-077-863-03597
eLife

Public Release: 15-Sep-2015
Nature Protocols
A technique dating back to 1935 is recovered for cancer research in flies
A study conducted by ICREA researcher Cayetano González, at the Institute for Research in Biomedicine, and published in Nature Protocols describes a forgotten technique used in the fly Drosophila melanogaster dating back 80 years. This method allows the transplantation of tissue from larvae to adult flies, thus allowing research into tumor growth and other biological processes of biomedical interest, such as tissue regeneration.

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)

Public Release: 15-Sep-2015
Epigenetics and Chromatin
Scientists discover how cells overpower cancer drug
Cancer Research UK scientists have found how cells adapt to overcome cancer drugs designed to interfere with their genetic controls, according to a study published Wednesday in Epigenetics and Chromatin.
Cancer Research UK

Contact: Emily Head
emily.head@cancer.org.uk
44-203-469-6189
Cancer Research UK

Public Release: 15-Sep-2015
PLOS ONE
Virus in cattle linked to human breast cancer
A new study by UC Berkeley researchers establishes for the first time a link between infection with the bovine leukemia virus and human breast cancer.
University of California Breast Cancer Research Program, DOD/Breast Cancer Research Program

Contact: Sarah Yang
scyang@berkeley.edu
510-643-7741
University of California - Berkeley

Showing releases 1076-1100 out of 1304.

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