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Showing releases 1101-1125 out of 1241.

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Public Release: 13-May-2014
Review of Scientific Instruments
MEMS nanoinjector for genetic modification of cells
The ability to transfer a gene or DNA sequence from one animal into the genome of another plays a critical role in a wide range of medical research -- including cancer, Alzheimer's disease, and diabetes, and now there's a way to avoid cell death when introducing DNA into egg cells. In Review of Scientific Instruments, the team describes its microelectromechanical system nanoinjector, which was designed to inject DNA into mouse zygotes.

Contact: Jason Socrates Bardi
American Institute of Physics

Public Release: 13-May-2014
Study findings question benefit of additional imaging before cancer surgery
Among patients with a certain type of colorectal cancer with limited spread to the liver, imaging using positron emission tomography and computed tomography (CT) before surgery did not significantly change the surgical treatment of the cancer, compared with CT alone, according to a study in the May 14 issue of JAMA.

Contact: Veronica McGuire
The JAMA Network Journals

Public Release: 12-May-2014
Breast Cancer Research and Treatment
Triple negative breast cancer, ethnicity, and socioeconomic status
An analysis of a large nationwide dataset finds that regardless of their socioeconomic status, black women were nearly twice as likely as white women to be diagnosed with triple-negative breast cancer, a subtype that has a poorer prognosis.
American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 12-May-2014
Clinical Cancer Research
A form of immune therapy might be effective for multiple myeloma
A new study provides evidence that genetically modified immune cells might effectively treat multiple myeloma, a disease that remains incurable and will account for an estimated 24,000 new cases and 11,100 deaths in 2014. The researchers modified T lymphocytes to target a molecule called CS1, which is found on myeloma cells, and to kill the cells. The findings support testing the potential therapy in a clinical trial.
National Institutes of Health, Multiple Myeloma Opportunities for Research and Education

Contact: Darrell E. Ward
Ohio State University Wexner Medical Center

Public Release: 12-May-2014
JAMA Internal Medicine
Diets rich in antioxidant resveratrol fail to reduce deaths, heart disease or cancer
A study of Italians who consume a diet rich in resveratrol -- the compound found in red wine, dark chocolate and berries -- finds they live no longer than and are just as likely to develop cardiovascular disease or cancer as those who eat or drink smaller amounts of the antioxidant.
NIH/National Institute on Aging, NIH/National Heart, Lung and Blood Institute

Contact: Stephanie Desmon
Johns Hopkins Medicine

Public Release: 12-May-2014
US cervical cancer rates higher than previously reported, especially among older women
Cervical cancer rates in the United States are higher than previously believed, particularly among 65- to 69-year-old women and African-American women, according to a study led by a researcher at the University of Maryland School of Medicine published in the journal Cancer. Current US cervical cancer screening guidelines do not recommend routine Pap smears for women over 65 if their prior test results have been normal.
NIH/National Cancer Institute, and others

Contact: Karen Warmkessel
University of Maryland Medical Center

Public Release: 12-May-2014
Cancer Cell
Two genes together drive aggressive prostate cancer
Two genes work together to drive the most lethal forms of prostate cancer, according to new research from the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center. These findings could lead to a diagnostic test for identifying those tumors likely to become aggressive and to the development of novel combination therapy for the disease.
National Institutes of Health

Contact: Karin Eskenazi
Columbia University Medical Center

Public Release: 12-May-2014
JAMA Internal Medicine
Resveratrol in red wine, chocolate, grapes not associated with improved health
The antioxidant resveratrol found in red wine, chocolate and grapes was not associated with longevity or the incidence of cardiovascular disease, cancer and inflammation.

Contact: Stephanie Desmon
The JAMA Network Journals

Public Release: 12-May-2014
Current guidelines underestimate US cervical cancer incidence and older women's risk
Rates of cervical cancer in American women may be higher than previously thought, and the disease may arise most often at an age when adequately screened women are advised to stop getting screened. The findings come from a new study published early online in CANCER, a peer-reviewed journal of the American Cancer Society. The results should be taken into consideration when the national guidelines for cervical cancer screening are reviewed.

Contact: Evelyn Martinez

Public Release: 12-May-2014
Scientists slow brain tumor growth in mice
Much like using dimmer switches to brighten or darken rooms, biochemists have identified a protein that can be used to slow down or speed up the growth of brain tumors in mice.
Department of Defense, National Institutes of Health, Houston Endowment, Inc.

Contact: Robert Cahill
University of Texas Health Science Center at Houston

Public Release: 12-May-2014
Journal of Experimental Medicine
New cancer immunotherapy aims powerful T cells against tumors
Deadly skin cancers in mice shrank in response to a new treatment that may complement other 'immunotherapies' developed recently to boost the body's own defenses against disease threats, according to a new study published by UC San Francisco researchers in the May 2014 edition of the Journal of Experimental Medicine.
National Institute of Health, University of California, San Francisco Institutional Research and Career Development Award Scholars in Science Postdoctorate Scholars Program, University of California, San Fransisco Medical Scientists Training Program

Contact: Jeffrey Norris
University of California - San Francisco

Public Release: 12-May-2014
Proceedings of the National Academy of Sciences
Scientists from USC and NYU design a molecule that blocks cancer growth in mice
New cancer-fighting drug prevents two critical proteins from interacting by mimicking the surface topography of one protein -- like wearing a mask -- which tricks the other protein into binding with it.
National Science Foundation, New York University Perlmutter Cancer Center

Contact: Robert Perkins
University of Southern California

Public Release: 12-May-2014
Clinical Chemistry
Dartmouth scientists identify genetic blueprint for cancerous tumors of the appendix
Using next generation DNA sequencing, Dartmouth scientists have identified potentially actionable mutations in cancers of the appendix. Their study, 'Molecular Profiling of Appendiceal Epithelial Tumors Using Massively Parallel Sequencing to Identify Somatic Mutations,' was published in the journal Clinical Chemistry today. When specific mutations for a cancer type are identified, patients can be treated with chemotherapy or other targeted agents that work on those mutations.

Contact: Robin Dutcher
The Geisel School of Medicine at Dartmouth

Public Release: 12-May-2014
Proceedings of the National Academy of Sciences
JAX researchers identify potential therapeutic target for wound-healing and cancer
A Jackson Laboratory research team led by Professor Lenny Shultz, Ph.D., reports that a protein involved in wound healing and tumor growth (an inactive rhomboid protease, iRhom2) could be a potential therapeutic target.
National Institutes of Health

Contact: Joyce Peterson
Jackson Laboratory

Public Release: 12-May-2014
Clinical Neurology and Neurosurgery
Henry Ford researchers identify genetic factors that may aid survival from brain cancer
A Henry Ford Hospital research team has identified specific genes that may lead to improved survival of glioblastoma, the most common and deadly form of cancerous brain tumor. The molecular data is expected to aid further research into genes that either help or impede the survival of patients diagnosed with the tumor, which can invade and rapidly grow in any part of the human brain.
Hermelin Brain Tumor Center, National Institutes of Health, Cancer Genome Atlas

Contact: Dwight Angell
Henry Ford Health System

Public Release: 12-May-2014
Journal of Clinical Oncology
Second opinion changes diagnosis from incurable to curable cancer
The Journal of Clinical Oncology reports the case of a woman diagnosed with advanced, incurable lung cancer, whose disease was in fact early stage, curable lung cancer with additional lung lesions due to a rare antibiotic side effect.

Contact: Erika Matich
University of Colorado Denver

Public Release: 11-May-2014
Proceedings of the National Academy of Sciences
Revealed:Protein's role in preventing heart muscle growth leading to heart failure
Hebrew University Faculty of Medicine researchers showed for the first time that the protein Erbin is an important brake that helps prevent pathological cardiac hypertrophy. They showed that damage to this protein leads to excess growth of heart muscle, a decrease in function, and severe pathological growth of heart muscle. Their research has implications for breast cancer treatment, as Erbin interacts with the receptor Her2/ErBb2, which is overexpressed in approximately 30 percent of breast cancers.
United States Binational Science Foundation, Israeli Academy of Science, and others

Contact: Dov Smith
The Hebrew University of Jerusalem

Public Release: 9-May-2014
Angewandte Chemie
New method sneaks drugs into cancer cells before triggering release
Biomedical engineering researchers have developed an anti-cancer drug delivery method that essentially smuggles the drug into a cancer cell before triggering its release. The method can be likened to keeping a cancer-killing bomb and its detonator separate until they are inside a cancer cell, where they then combine to destroy the cell.
National Institutes of Health

Contact: Matt Shipman
North Carolina State University

Public Release: 9-May-2014
EMBO Molecular Medicine
Plugging leaky blood vessels to save vision
A new drug approach has been developed for safer clean-up of deformed blood vessels in the eye by a research team at the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital in Toronto.
Canadian Institutes of Health Research

Contact: Polly Thompson
Lunenfeld-Tanenbaum Research Institute

Public Release: 9-May-2014
Nature Communications
Properties of water at nanoscale will help to design innovative technologies
Scientists from Politecnico di Torino (Turin, Italy) and Houston Methodist Research Institute (Houston, USA) have just proposed on Nature Communications a novel understanding of unexpected water properties at the nanoscale in the close proximity of solid surfaces. More rationally designed contrast agents for improved Magnetic Resonance Imaging performances are the first applications of the discovery.

Contact: Tiziana Vitrano
Politecnico di Torino

Public Release: 9-May-2014
Cell Reports
Scientists decode epigenetic mechanisms distinguishing stem cell function and blood cancer
Researchers at Dartmouth's Norris Cotton Cancer Center have published results from a study in Cell Reports that discovers a new mechanism that distinguishes normal blood stem cells from blood cancers.
National Institutes of Health, American Cancer Society, Gabriel's Angel Foundation

Contact: Donna Dubuc
The Geisel School of Medicine at Dartmouth

Public Release: 9-May-2014
Nature Neuroscience
Discovery links rare, childhood neurodegenerative diseases to common problem in DNA repair
St. Jude Children's Research Hospital scientists studying two rare, inherited childhood neurodegenerative disorders have identified a new, possibly common source of DNA damage that may play a role in other neurodegenerative diseases, cancer and aging. The findings appear in the current issue of the scientific journal Nature Neuroscience.
NIH/National Cancer Institute, National Institutes of Health, Geoffrey Beene Foundation, Goodwin Foundation, University of Manitoba, CancerCare Manitoba, and others

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

Public Release: 8-May-2014
Science Signaling
Chemotherapy timing is key to success
Nanoparticles that stagger delivery of two drugs knock out aggressive tumors.

Contact: Andrew Carleen
Massachusetts Institute of Technology

Public Release: 8-May-2014
Honolulu-based study reveals shorter men live longer
Short height and long life have a direct connection in Japanese men, according to new research based on the Kuakini Honolulu Heart Program and the Kuakini Honolulu-Asia Aging Study. Shorter men are more likely to have a protective form of the longevity gene, FOXO3, leading to smaller body size during early development and a longer lifespan. Shorter men are also more likely to have lower blood insulin levels and less cancer.

Contact: Tina Shelton
University of Hawaii at Manoa

Public Release: 8-May-2014
Journal of Clinical Investigation
JCI online ahead of print table of contents for May 8, 2014
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers published online, May 8, 2014, in the JCI: 'Leptin-dependent regulation of reproduction,' 'Female susceptibility to CNS autoimmunity linked to sphingosine-1 phosphate receptor,' 'Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction,' 'Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus,' 'Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm,' and more.

Contact: Corinne Williams
Journal of Clinical Investigation

Showing releases 1101-1125 out of 1241.

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