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Showing releases 1101-1125 out of 1207. << < 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 > >>
Public Release: 8-Dec-2012
2012 CTRC-AACR San Antonio Breast Cancer SymposiumResearchers develop novel 3-D culture system for inflammatory breast cancer Inflammatory breast cancer is a very rare and aggressive disease. To understand how this type of cancer spreads, it's crucial to characterize the interactions between cancer cells and their 3-D environment. Researchers at Fox Chase Cancer Center have developed a novel, 3-D culture system that mimics the environment surrounding these cancer cells. This model could be used to test new anticancer drugs capable of inhibiting the spread of IBC tumors. Contact: Diana Quattrone
Public Release: 7-Dec-2012
2012 CTRC-AACR San Antonio Breast Cancer SymposiumNew small molecule inhibitor could be a safe and first-line treatment for metastatic breast cancer Previous research has shown that a family of genes, proteins and enzymes called the uPA system (for urokinase plasminogen activator) plays an active role in different facets of cancer's biology, including tumor cell invasion, the spread of metastases, and the growth of a primary tumor. Contact: Diana Quattrone
Public Release: 7-Dec-2012
2012 CTRC-AACR San Antonio Breast Cancer Symposium Cancer DiscoveryExisting drugs may help more breast cancer patients More patients can benefit from highly effective breast cancer drugs that are already available, according to DNA sequencing studies by researchers at Washington University School of Medicine in St. Louis and other institutions. 
National Institutes of Health, and others
Contact: Julia Evangelou Strait
Public Release: 7-Dec-2012
2012 CTRC-AACR San Antonio Breast Cancer SymposiumMayo Clinic IDs genes that predict whether trastuzumab will work for breast cancer patients A team of US researchers, led by oncologists at Mayo Clinic's campus in Florida, have discovered 27 genes that are significantly associated with a good outcome with concurrent use of trastuzumab and chemotherapy, as well as five other genes linked to a poor outcome using the same treatment regimen.
NIH/National Cancer Institute, Mayo Clinic, Breast Cancer Research Foundation, 26.2 with Donna Foundatio
Contact: Joe Dangor
Public Release: 7-Dec-2012
2012 CTRC-AACR San Antonio Breast Cancer SymposiumProtein tied to cancer-drug resistance in mice Blocking a specific protein renders tumors more vulnerable to treatment in mice, suggesting new therapies could eventually achieve the same in humans, according to new research from Fox Chase Cancer Center to be presented at the 2012 CTRC-AACR San Antonio Breast Cancer Symposium on Friday, Dec. 7, 2012. Contact: Diana Quattrone
Public Release: 7-Dec-2012
Cancer ResearchObesity and overeating during menopause together promote breast tumor growth and progression In a rat model, premenopausal obesity impaired ability to handle postmenopausal overeating. Obese animals' tumors expressed more markers of increased energy use and proliferation. Results have implications for weight and metabolic control in perimenopausal women. Contact: Jeremy Moore
Public Release: 7-Dec-2012
Journal of Medical Internet Research1 in 4 physicians uses social media daily A new survey shows that about one in four physicians uses social media daily or multiple times a day to scan or explore medical information, and 14 percent use social media each day to contribute new information, according to an oncologist at the Johns Hopkins Kimmel Cancer Center.
Pfizer
Contact: Vanessa Wasta
Public Release: 7-Dec-2012
2012 CTRC-AACR San Antonio Breast Cancer SymposiumStudy compares standard against newer treatment in women whose breast cancer has spread Results from a phase III clinical trial comparing a newer chemotherapy agent called eribulin mesylate with capecitabine, a standard drug used for chemotherapy today in women with previously treated metastatic breast cancer, showed that eribulin demonstrated a trend toward improved overall survival. This study was presented today by Peter A. Kaufman, M.D., during the 2012 CTRC-AACR San Antonio Breast Cancer Symposium. Contact: Donna M. Dubuc
Public Release: 7-Dec-2012
2012 CTRC-AACR San Antonio Breast Cancer SymposiumVanderbilt study finds diverse genetic alterations in triple-negative breast cancers Most triple-negative breast cancer patients who were treated with chemotherapy to shrink the tumor prior to surgery still had multiple genetic mutations in their tumor cells, according to a study by Vanderbilt-Ingram Cancer Center investigators.
NIH/National Cancer Institute, Susan G. Komen for the Cure Foundation
Contact: Dagny Stuart
Public Release: 7-Dec-2012
DNA Vaccines 2012 ConferenceWinning the battle against leukaemia: Positive early results in clinical trial for DNA vaccine Early results of a trial to treat leukaemia with a WT1 DNA vaccine, has shown robust vaccine-specific antibody responses in all vaccinated patients evaluated to date. Contact: Becky Attwood
Public Release: 6-Dec-2012
CellResearchers discover regulator linking exercise to bigger, stronger muscles Scientists at Dana-Farber Cancer Institute have isolated a previously unknown protein in muscles that spurs their growth and increased power following resistance exercise. They suggest that artificially raising the protein's levels might someday help prevent muscle loss caused by cancer, prolonged inactivity in hospital patients, and aging.
Novartis
Contact: Robbin Ray
Public Release: 6-Dec-2012
British Medical JournalUniversity of East Anglia research proves low fat diet is key to a slimmer figure Findings published today in the British Medical Journal show that exchanging fatty foods for lower fat alternatives will help people shift around three-and-a-half pounds -- without dieting. People taking part in trials also saw their waist-lines become slimmer, and levels of bad cholesterol decrease. The results prove for the first time that weight loss can happen without trying to lose weight -- simply by choosing foods lower in fat. Contact: Lisa Horton
Public Release: 6-Dec-2012
ImmunityImmune system kill switch could be target for chemotherapy and infection recovery Researchers have discovered an immune system 'kill switch' that destroys blood stem cells when the body is under severe stress, such as that induced by chemotherapy and systemic infections. The discovery could have implications for protecting the blood system during chemotherapy or in diseases associated with overwhelming infection, such as sepsis.
National Health and Medical Research Council of Australia, Australian Research Council, and others
Contact: Liz Williams
Public Release: 6-Dec-2012
CellBiochemists trap a chaperone machine in action Molecular chaperones have emerged as exciting new potential drug targets, because scientists want to learn how to stop cancer cells, for example, from using chaperones to enable their uncontrolled growth. Now a team of biochemists at the University of Massachusetts Amherst led by Lila Gierasch have deciphered key steps in the mechanism of the Hsp70 molecular machine by "trapping" this chaperone in action, providing a dynamic snapshot of its mechanism.
National Institutes of Health, NIH/National Institute of General Medical Sciences
Contact: Janet Lathrop
Public Release: 6-Dec-2012
Cell Stem CellA relationship between cancer genes and the reprogramming gene SOX2 discovered Two studies discover the relationship between two cancer genes, CDKN1B(p27) and MEF, and the reprogramming gene SOX2. Contact: Nuria Noriega
Public Release: 6-Dec-2012
CellProtein controlling glucose metabolism also a tumor suppressor A protein that regulates how cells process glucose also may be a tumor suppressor, adding to the potential that therapies directed at cellular metabolism may help suppress tumor growth. The multi-institutional research team describes finding that cells lacking the enzyme SIRT6, which controls how cells process glucose, quickly become cancerous. They also found evidence that uncontrolled glycolysis may drive tumor formation in the absence of SIRT6 and that suppressing glycolysis can halt tumor formation.
National Institutes of Health
Contact: Katie Marquedant
Public Release: 6-Dec-2012
Journal of the National Cancer InstituteWomen with higher carotenoid levels have reduced risk of breast cancer Women with higher circulating carotenoid levels are at a reduced risk of breast cancer according to a study published Dec. 6 in the Journal of the National Cancer Institute. Contact: Zachary Rathner
Public Release: 6-Dec-2012
2012 CTRC-AACR San Antonio Breast Cancer SymposiumTamoxifen trial should prompt breast cancer patients to reconsider treatment options A groundbreaking clinical trial involving the breast cancer drug tamoxifen should prompt certain breast cancer patients to reconsider their treatment options. Contact: Jim Ritter
Public Release: 6-Dec-2012
2012 CTRC-AACR San Antonio Breast Cancer SymposiumAttitudes predict ability to follow post-treatment advice Women are more likely to follow experts' advice on how to reduce their risk of an important side effect of breast cancer surgery--like lymphedema--if they feel confident in their abilities and know how to manage stress, according to new research from Fox Chase Cancer Center to be presented at the 2012 CTRC-AACR San Antonio Breast Cancer Symposium on Saturday, Dec. 8, 2012. Contact: Diana Quattrone
Public Release: 6-Dec-2012
2012 CTRC-AACR San Antonio Breast Cancer Symposium Molecular Cancer TherapeuticsTGen-US Oncology data guides treatment of metastatic triple-negative breast cancer patients Genomic sequencing has revealed therapeutic drug targets for difficult-to-treat, metastatic triple-negative breast cancer, according to an unprecedented study by the Translational Genomic Research Institute and US Oncology Research.
Life Technologies Corporation
Contact: Steve Yozwiak
Public Release: 6-Dec-2012
2012 CTRC-AACR San Antonio Breast Cancer SymposiumUT MD Anderson study finds link between statins and improved survival in inflammatory breast cancer Researchers from the University of Texas MD Anderson Cancer Center found statins, the commonly used drug to lower cholesterol, improved progression-free survival in patients with inflammatory breast cancer. Contact: William Fitzgerald
Public Release: 6-Dec-2012
Journal of Experimental MedicineCocktail boosts immune cells in fighting cancer Natural killer cells, as part of the body´s immune system, can effectively fight cancer. Unfortunately, they quickly lose their aggressiveness and hence are unable to reject solid tumors. Scientists from the German Cancer Research Center have now discovered a cocktail consisting of three different immune mediators that leaves NK killer cells active over a long period of time. In mice, cocktail-boosted NK cells let tumors shrink. The cocktail -was able to persistently activate human NK cells, too. Contact: Dr. Sibylle Kohlstädt
Public Release: 6-Dec-2012
Aging CellNew evidence for epigenetic effects of diet on healthy aging New research in human volunteers has shown that molecular changes to our genes, known as epigenetic marks, are driven mainly by aging but are also affected by what we eat. The study showed that whilst age had the biggest effects on these molecular changes, selenium and vitamin D status reduced their accumulation, and high blood folate and obesity increased them. These findings support the idea that healthy aging is affected by what we eat.
BBSRC, FSA
Contact: Andrew Chapple
Public Release: 6-Dec-2012
NatureMy microbes We all have E.coli bacteria in our gut but each of us carries a version that is genetically slightly different. The same can be said of most gut microbes: our own gut metagenome, that is the collection of all the genes of all our gut microbes, appears to be really specific to each of us, and to remain stable over time. These findings, published in Nature, could have widespread consequences in medicine. Contact: Isabelle Kling
Public Release: 6-Dec-2012
ScienceGladstone scientists discover novel mechanism by which calorie restriction influences longevity Scientists at the Gladstone Institutes have identified a novel mechanism by which a type of low-carb, low-calorie diet--called a "ketogenic diet"--could delay the effects of aging. This fundamental discovery reveals how such a diet could slow the aging process and may one day allow scientists to better treat or prevent age-related diseases, including heart disease, Alzheimer's disease and many forms of cancer.
Gladstone Institutes
Contact: Anne Holden
Showing releases 1101-1125 out of 1207. << < 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 > >>
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