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Public Release: 5-Feb-2016
Journal of Molecular Diagnostics
New assay detects persistent disease in leukemia patients thought to be in remission
A study in The Journal of Molecular Diagnostics describes a new personalized DNA-based digital assay that detects persistent chronic myeloid leukemia in 81 percent of samples taken from a group of patients thought to be in remission.
LEUKA Charity, NIHR Biomedical Research Center Funding Scheme, and Imperial College High Performance Computing Service

Contact: Eileen Leahy
Elsevier Health Sciences

Public Release: 5-Feb-2016
Cancer Discovery
Single-lesion biopsy may be insufficient to choose therapy targeting resistance mutations
When metastatic tumors driven by drug-targetable genetic mutations become resistant to a targeted therapy drug, the usual practice is to test a single metastatic lesion for new mutations that can guide the selection of next-line therapies. But this strategy may miss additional targetable mutations that arise in different metastases, a new study finds.
NIH/National Cancer Institute, Damon Runyon Foundation

Contact: Katie Marquedant
Massachusetts General Hospital

Public Release: 5-Feb-2016
Journal of Molecular Biology
NIH researchers identify striking genomic signature shared by 5 types of cancer
National Institutes of Health researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer. The specific signature results from a chemical modification of DNA called methylation, which can control the expression of genes like a dimmer on a light switch. Based on this advance, the researchers hope to spur development of a blood test that can be used to diagnose a variety of cancers at early stages.

Contact: Jeannine Mjoseth
NIH/National Human Genome Research Institute

Public Release: 5-Feb-2016
Science Advances
Protein that switches cancers from inflammation to proliferation identified
PAD4 has been observed in cancers but its role was unclear. An Oxford University team have found that PAD4 citrullinates protein E2F-1, which causes it to form a protein complex with BRD4 that drives expression of inflammatory genes.
UK Medical Research Council UK, Cancer Research UK, Rosetrees Trust

Contact: Tom Calver
University of Oxford

Public Release: 5-Feb-2016
Gene family turns cancer cells into aggressive stem cells that keep growing
An examination of 130 gene expression studies in 10 solid cancers has found that when any of four related genes is overexpressed, patients have much worse outcomes, including reduced survival.
NIH/National Cancer Institute, American Cancer Society Institutional Research Grant

Contact: Karen Teber
Georgetown University Medical Center

Public Release: 5-Feb-2016
Bone Marrow Transplantation
Cancer treatment: Therapeutic approach gives hope for the treatment of multiple myeloma
A new therapeutic approach tested by a team from Maisonneuve-Rosemont Hospital and the University of Montreal gives promising results for the treatment of multiple myeloma, a cancer of the bone marrow currently considered incurable with conventional chemotherapy. The study resulted in a total cure rate of 41 percent, a record level using this strategy. Moreover, patients in complete remission six months after the allograft had a relapse-free survival rate of 60 percent.
University of Montreal's William Brock Fund

Contact: Julie Gazaille
University of Montreal

Public Release: 4-Feb-2016
Cell Reports
New clues to common and elusive KRAS cancer gene
One of the most common cancer-causing genes has continuously stymied researchers' efforts to develop treatments against it. Now, researchers at the University of Michigan Comprehensive Cancer Center have dug deeper and exposed a key interaction that may contribute to why mutations in KRAS lead to cancer.
IFOM Fondazione Istiuto FIRC di Oncologia Molecolare, Howard Hughes Medical Institute, Damon Runyon Foundation, A. Alfred Taubman Medical Research Institute, American Cancer Society, National Institutes of Health, Prostate Cancer Foundation

Contact: Nicole Fawcett
University of Michigan Health System

Public Release: 4-Feb-2016
Clinical Proteomics
The test that reveals cancer sooner
MorNuCo Laboratories' clinical trial, recently published in Clinical Proteomics, demonstrated the ability of a serum test to detect the presence of mesothelioma 4-10 years in advance of clinical symptoms. The ONCOblot® Test detects ENOX2 proteins present in serum, and in this trial, ENOX2 proteins that are specific to mesothelioma. This is an exciting step forward in the continued development of tools for early cancer detection.

Contact: Rebecca Davis
ONCOblot Labs

Public Release: 4-Feb-2016
Journal of the American College of Radiology
Meditation eases pain, anxiety and fatigue during breast cancer biopsy
Meditation eases anxiety, fatigue and pain for women undergoing breast cancer biopsies, according to researchers at the Duke Cancer Institute. They also found that music is effective, but to a lesser extent.

Contact: Sarah Avery
Duke University Medical Center

Public Release: 4-Feb-2016
Cell Stem Cell
How gut inflammation sparks colon cancer
Duke biomedical engineers have shown how colon cancer development is intricately linked to a specific microRNA that dictates how cells divide. The new study points to a link between chronic gut inflammation and an increased risk of colon cancer. That link could not only serve as an early warning signal of colon cancer, but potentially be harnessed to counteract advanced forms of the disease, the second-largest cause of cancer death in the US.
National Institutes of Health, National Science Foundation, New York State Stem Cell Science, Defense Advanced Research Projects Agency

Contact: Ken Kingery
Duke University

Public Release: 4-Feb-2016
Current Biology
Stopping tumor cells killing surrounding tissue may provide clue to fighting cancer
Cancer cells kill off surrounding cells to make room to grow, according to new research from the University of Cambridge. Although the study was carried out using fruit flies, its findings suggest that drugs to prevent, rather than encourage, cell death might be effective at fighting cancer -- contrary to how many of the current chemotherapy drugs work.
Cancer Research UK

Contact: Craig Brierley
University of Cambridge

Public Release: 4-Feb-2016
Cancer Research
Tuning macrophages a 'breakthrough' in cancer immunotherapy
A University of Colorado Cancer Center article in the journal Cancer Research describes 'tuning' macrophages from ones that repair wounds (and contribute to tumor growth) to ones that sterilize wounds (and contribute to the immune system's attack of tumor tissue).
National Institutes of Health

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 4-Feb-2016
CRI develops approach for identifying processes that fuel tumor growth in lung cancer patients
Scientists at the Children's Medical Center Research Institute at UT Southwestern have pioneered a new method for conducting in-depth research on malignant tumors in patients, in the process discovering new complexities underlying cancer biology and overturning a nearly century-old perception about cancer metabolism.
National Institutes of Health, Welch Foundation, Cancer Prevention and Research Institute of Texas, Canadian Institutes of Health Research, V Foundation, Children's Medical Center Foundation

Contact: Mark Lane
UT Southwestern Medical Center

Public Release: 4-Feb-2016
Bone loss associated with leukemia therapy occurs sooner than previously thought
Investigators at Children's Hospital Los Angeles have found that significant bone loss -- a side effect of chemotherapy for acute lymphoblastic leukemia (ALL) - occurs during the first month of treatment, far earlier than previously assumed. Results of the study will be available online Feb. 4, in advance of publication in the journal Bone.
Leukemia and Lymphoma Society, Southern California Clinical and Translational Science Institute, NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development

Contact: E. Kavanagh
Children's Hospital Los Angeles

Public Release: 4-Feb-2016
LGBT Health
Health-care disparities contribute to delayed testicular cancer diagnosis in a transgender woman
A family physician reports the case of a transgender woman whose testosterone levels rose unexpectedly while on feminizing hormones, leading eventually to a diagnosis of a rare, virilizing form of testicular cancer. The complex medical and psychosocial factors related to the care of transgender patients that contributed to the delay in diagnosis are examined in the study published in LGBT Health.

Contact: Kathryn Ryan
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 4-Feb-2016
Harnessing the power of light to fight cancer
Immunotherapy is one of the hottest emerging areas of cancer research. Using the body's own cells to fight cancer can be more effective and less invasive than flooding the entire system with toxic chemicals. Yubin Zhou, Ph.D., assistant professor at the Center for Translational Cancer Research at the Texas A&M Health Science Center Institute of Biosciences & Technology, is studying how to use light to control the immune system and induce it to fight cancer.
National Institutes of Health, Leukemia and Lymphoma Society, Human Frontier Science Program, China Scholarship Council, National Natural Science Foundation of China, Texas A&M University Health Science Center Startup Fund

Contact: Holly Shive
Texas A&M University

Public Release: 4-Feb-2016
Science Translational Medicine
Dogs accelerate the advance of new cancer treatments for both pets and people
A Science Translational Medicine review suggests integrating dogs with naturally occurring cancers into studies of new drug therapeutics could result in better treatments for our four-legged friends while helping inform therapeutic development for human cancers. The review, which included faculty at the Translational Genomics Research Institute, hopes to close the gap between human and canine cancer research, and accelerate the knowledge developed by studying cancer in both people and pets, a field known as comparative oncology.

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Public Release: 3-Feb-2016
Nature Communications
CNIO scientists find new tumor markers for the prognosis of head and neck cancer
Researchers have found that these tumors can be classified into two types using the p21 and mTOR markers . The presence of these markers corresponds to a less aggressive evolution of the disease. This could be the basis for more specific treatments depending on the type of cancer. Head and neck cancers are listed sixth in incidence and constitute the eighth leading cause of death by cancer.

Contact: Vanessa Pombo
Centro Nacional de Investigaciones Oncológicas (CNIO)

Public Release: 3-Feb-2016
American Journal of Clinical Oncology
No proof that radiation from X rays and CT scans causes cancer
The widespread belief that radiation from X rays, CT scans and other medical imaging can cause cancer is based on an unproven, decades-old theoretical model, according to a study published in the American Journal of Clinical Oncology.

Contact: Jim Ritter
Loyola University Health System

Public Release: 3-Feb-2016
Genes & Development
Enzyme key to link between age-related inflammation and cancer
For the first time, researchers have shown that an enzyme key to regulating gene expression -- and also an oncogene when mutated -- is critical for the expression of numerous inflammatory compounds that have been implicated in age-related increases in cancer and tissue degeneration, according to new research from Penn. Inhibitors of the enzyme are being developed as a new anti-cancer target.
NIH/National Institute of Aging, Dermatology Foundation, American Skin Association, and Melanoma Research Foundation

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 3-Feb-2016
New England Journal of Medicine
Preventive surgery for women at high risk of breast and ovarian cancer
In a review article published in the Feb. 4 issue of the New England Journal of Medicine, a pair of Mayo Clinic Cancer Center researchers provide an in-depth look at the issues associated with the care of women in families with hereditary breast and ovarian cancer syndrome who have not yet developed cancer themselves.

Contact: Joe Dangor
Mayo Clinic

Public Release: 3-Feb-2016
Hepatitis virus-like particles as potential cancer treatment
UC Davis researchers have developed a way to use the empty shell of a hepatitis E virus to carry vaccines or drugs into the body. The technique has been tested in rodents as a way to target breast cancer, and is available for commercial licensing through UC Davis Office of Research.
National Institutes of Health, Academia Sinica

Contact: Andy Fell
University of California - Davis

Public Release: 3-Feb-2016
Breakthrough in generating embryonic cells that are critical for human health
Critical for human development and health, neural crest cells arise early in the development of vertebrates. They migrate extensively inside the embryo, and differentiate to give rise to a wide array of diverse derivatives. Accessing these cells, however, is difficult. Work done by a research team led by a UC Riverside biomedical scientist now provides a fast, simple and cost-effective method to generate neural crest cells, facilitating research in basic sciences and clinical applications alike.
NIH/National Institute of Dental and Craniofacial Research, Connecticut Innovations

Contact: Iqbal Pittalwala
University of California - Riverside

Public Release: 3-Feb-2016
Cancer Research
Nutrient deprivation kills kidney cancer cells
Duke researchers have exploited the greedy metabolism of cancer cells to target kidney cell carcinomas, which kill more than 100,000 Americans each year. The team showed that the majority of renal cell cancers rewire their metabolism in a way that leaves them addicted to the nutrient cystine. By depriving the cancer cells of cystine, the researchers were able to trigger a form of cell death called necrosis in tumor cells.
National Institutes of Health, Department of Defense, Duke Cancer Center Pilot Project fund

Contact: Karl Bates
Duke University

Public Release: 3-Feb-2016
Cochrane Library
Cochrane news: Have national smoking bans worked in reducing harms in passive smoking?
The most robust evidence yet, published today in the Cochrane Library, suggests that national smoking legislation does reduce the harms of passive smoking, and particularly risks from heart disease.

Contact: Dawn Peters

Showing releases 1101-1125 out of 1353.

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