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Showing releases 1101-1125 out of 1371.

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Public Release: 6-Mar-2015
Nature Genetics
Chromosomal rearrangement is the key to progress against aggressive infant leukemia
The St. Jude Children's Research Hospital -- Washington University Pediatric Cancer Genome Project reports that a highly aggressive form of leukemia in infants has surprisingly few mutations beyond the chromosomal rearrangement that affects the MLL gene. The findings suggest that targeting the alteration is likely the key to improved survival. The research appeared online ahead of print this week in the scientific journal Nature Genetics.
Kay Jewelers, National Institutes of Health, Swedish Childhood Cancer Society, Swedish Research Council, Swedish Cancer Society, BioCARE, Gunnar Nilsson Cancer Foundation, ALSAC

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Public Release: 6-Mar-2015
ENDO 2015: The 97th Annual Meeting & EXPO in San Diego, CA
Menopausal hormone therapy does not affect the risk of dying, study shows
Menopausal hormone therapy does not have a significant effect on death, according to a new review of the medical literature published over the past three decades. The results, which included studies with follow-up as long as 18 years, will be presented Friday at the Endocrine Society's 97th annual meeting in San Diego.

Contact: Aaron Lohr
alohr@endocrine.org
202-971-3654
The Endocrine Society

Public Release: 6-Mar-2015
The Oncologist
Oncologists see gene expression profiling tests as helpful but have concerns
Oncologists praise gene expression profiling tests as a decision-making tool for women with early-stage breast cancer but also have significant reservations.
Cancer Care Ontario, Ontario Institute for Cancer Research, Canadian Centre for Applied Research in Cancer Control

Contact: Leslie Shepherd
shepherdl@smh.ca
416-864-6094
St. Michael's Hospital

Public Release: 6-Mar-2015
Clinical and Translational Medicine
Review article provides new insights on how tumors metastasize
In a review article recently published in the journal Clinical and Translational Medicine, researchers from Boston University School of Medicine shed new light on the underlying processes of tumor metastasis and highlight the role of epigenetics in this process.

Contact: Gina DiGravio
ginad@bu.edu
617-638-8480
Boston University Medical Center

Public Release: 6-Mar-2015
LGBT Health
Risk of breast cancer in transgender persons -- a study of veterans
A study of breast cancer in transgender veterans has identified 10 new cases, increasing the total number of published cases in both female-to-male and male-to-female transgender persons. Patient outcomes, use of cross-sex hormones, and recommendations for screening are presented in an article in LGBT Health.

Contact: Kathryn Ryan
kryan@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 5-Mar-2015
JAMA Oncology
Trends of 21-gene recurrence score assay use in older patients with breast cancer
A genetic test for patients with breast cancer that helps to predict the risk of developing metastatic disease and the expected benefits of chemotherapy has been adopted quickly into clinical practice in a study of older patients and it appears to be used consistently within guidelines and equitably across geographic and racial groups, according to a study published online by JAMA Oncology.

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
The JAMA Network Journals

Public Release: 5-Mar-2015
JAMA Oncology
Effect of follow-up of MGUS on survival in patients with multiple myeloma
Patients with multiple myeloma appear to have better survival if they are found to have monoclonal gammopathy of undetermined significance first, the state that precedes MM and which is typically diagnosed as part of a medical workup for another reason, according to a study published online by JAMA Oncology.

Contact: Sigurdur Y. Kristinsson
sigyngvi@hi.is
The JAMA Network Journals

Public Release: 5-Mar-2015
Journal of the National Cancer Institute
Products advertised on personalized cancer care websites: True or false claims?
Although there are only a few validated genetic tests specifying individual risks for certain cancers or which can help to select genomically targeted cancer therapies, the Internet is already a major source of marketing for both legitimate tests as well as those of dubious value, according to a study published March 5 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
Zachary.Rathner@oup.com
919-677-2697
Oxford University Press USA

Public Release: 5-Mar-2015
Cell
In vivo CRISPR-Cas9 screen sheds light on cancer metastasis and tumor evolution
For the first time, CRISPR-Cas9 gene-editing technology has been employed in a whole organism model to systematically target every gene in the genome. A team of scientists have pioneered the use of this technology to 'knock out,' or turn off, all genes across the genome systematically in an animal model of cancer, revealing genes involved in tumor evolution and metastasis and paving the way for similar studies in other cell types and diseases.
National Institutes of Health, NIH/National Institute of Diabetes and Digestive and Kidney Diseases, NIH/National Institute of Mental Health

Contact: Paul Goldsmith
paulg@broadinstitute.org
617-714-8600
Broad Institute of MIT and Harvard

Public Release: 5-Mar-2015
Journal of the National Cancer Institute
Unregulated web marketing of genetic tests for personalized cancer care raises concerns
Websites that market personalized cancer care services often overemphasize their purported benefits and downplay their limitations, and many sites offer genetic tests whose value for guiding cancer treatment has not been shown to be clinically useful, according to a new study from Dana-Farber Cancer Institute.
American Cancer Society, National Institutes of Health

Contact: Anne Doerr
anne_doerr@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute

Public Release: 5-Mar-2015
Applied Physics Letters
Magnetic material attracts attention for cancer therapy
An extraordinary self-regulating heating effect that can be achieved in a particular type of magnetic material may open the doors to a new strategy for hyperthermia cancer treatment.

Contact: Glynis Smalley
glynis.smalley@monash.edu
61-408-027-848
Monash University

Public Release: 5-Mar-2015
ACS Nano
Medical nanoparticles: Local treatment of lung cancer
Nanoparticles can function as carriers for medicines to combat lung cancer: working in a joint project, scientists from the Helmholtz Zentrum München and the Ludwig-Maximilians-Universität in Munich have developed nanocarriers that site-selectively release medicines/drugs at the tumor site in human and mouse lungs. In the journal, ACS Nano, the scientists reported that this approach led to a significant increase in the effectiveness of current cancer medicines in lung tumor tissue.

Contact: Dr. Silke Meiners
silke.meiners@helmholtz-muenchen.de
49-089-318-74673
Helmholtz Zentrum München - German Research Center for Environmental Health

Public Release: 5-Mar-2015
Cellular and Molecular Gastroenterology and Hepatology
Understanding how the stomach responds to injury could help target therapy against gastric damage
A better understanding of the stomach's immune response to Helicobater pylori infection could lead to new therapies targeting damage in the stomach, report researchers in the March issue of Cellular and Molecular Gastroenterology and Hepatology, the basic science journal of the American Gastroenterological Association.
Victorian Government's Operational Infrastructure Support Program, National Health and Medical Research Council Australia

Contact: Rachel Steigerwald
media@gastro.org
301-272-1603
American Gastroenterological Association

Public Release: 5-Mar-2015
Nature Immunology
Energetic immune cells are vital for fighting disease
A good immune system relies on a key 'energy producing' protein in immune cells to develop immunity to vaccines and disease, an international team of scientists has found.
National Health and Medical Research Council, Biotechnology and Biological Sciences Research Council, The Victorian Government

Contact: Alan Gill
gill.a@wehi.edu.au
61-393-452-719
Walter and Eliza Hall Institute

Public Release: 4-Mar-2015
Molecular Systems Biology
Manipulating cells' shapes could treat breast cancer
Changing the shape of breast cancer cells could make the disease more sensitive to treatments -- even driving the body's own inflammatory response against a tumor -- a new study shows. Scientists at the Institute of Cancer Research, London, showed that the shape of a tumor cell is an important factor in determining its response to inflammatory molecules, which can either promote or inhibit cancer progression.
Cancer Research UK, Biotechnology and Biological Sciences Research Council, Wellcome Trust

Contact: Amy Drummond
amy.drummond@icr.ac.uk
44-207-153-5359
Institute of Cancer Research

Public Release: 4-Mar-2015
New England Journal of Medicine
Novel approach helps prevent early menopause in breast cancer patients, study finds
Early menopause can be prevented and fertility may be preserved in young women with early stage breast cancer, according to a study published today in the New England Journal of Medicine.

Contact: Nora Dudley
nodudley@lumc.edu
708-216-6268
Loyola University Health System

Public Release: 4-Mar-2015
New England Journal of Medicine
Hormone-blocking drug prevents ovarian failure and improves fertility in breast cancer patients
Breast cancer patients who are given the hormone-blocking drug goserelin during chemotherapy are less likely to experience ovarian failure and more likely to have successful pregnancies, according to results from the Prevention of Early Menopause Study to be published in the New England Journal of Medicine.

Contact: Maureen Nagg
naggm@ccf.org
216-213-2844
Cleveland Clinic

Public Release: 4-Mar-2015
Practical Radiation Oncology
ILROG issues treatment guidelines for pediatric Hodgkin lymphoma
The International Lymphoma Radiation Oncology Group has issued a guideline that outlines the use of 3-D computed tomography (CT)-based radiation therapy planning and volumetric image guidance to more effectively treat pediatric Hodgkin lymphoma and to reduce the radiation dose to normal tissue, thus decreasing the risk of late side effects.

Contact: Michelle Kirkwood
press@astro.org
703-286-1600
American Society for Radiation Oncology

Public Release: 4-Mar-2015
Cancer
Older, white males with advanced bladder cancer at high risk for suicide
Older, single white males with advanced bladder cancer have the highest suicide risk among those with other cancers of the male genitals and urinary system, researchers report.

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University

Public Release: 4-Mar-2015
Cochrane Database of Systematic Reviews
Family interventions reduce smoking rates in children and adolescents
A global review by Canada's University of Calgary and QUT into the effectiveness of family-based programs has found these programs can be highly effective in stopping children from taking up smoking.

Contact: Amanda Weaver
amanda.weaver@qut.edu.au
Queensland University of Technology

Public Release: 4-Mar-2015
Science Translational Medicine
Northeastern researchers make breakthrough discovery in cancer treatment
Michail Sitkovsky, an immunophysiology expert at Northeastern, and his research colleagues have found that supplemental oxygenation could shrink tumors and improve cancer immunotherapy.

Contact: Casey Bayer
c.bayer@neu.edu
617-373-2592
Northeastern University

Public Release: 3-Mar-2015
Neurosurgery
Brain tumor patients fare better with private insurance, new study finds
Brain tumor patients who are uninsured or use Medicaid stay hospitalized longer and develop more medical complications than those with private insurance, University of Florida Health researchers have found.

Contact: Doug Bennett
dougbennett@ufl.edu
352-273-5706
University of Florida

Public Release: 3-Mar-2015
Public Health Reports
UTMB study shows testosterone being prescribed when not medically needed
A new study by the University of Texas Medical Branch found that 20 percent of men were prescribed testosterone despite having normal testosterone levels based on the Endocrine Society's guidelines. The study also found that 39 percent of new testosterone users did not have a prostate cancer screening during the year before treatment and 56 percent were not screened during the year after starting treatment.
National Institutes of Health

Contact: Donna Ramirez
donna.ramirez@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston

Public Release: 3-Mar-2015
Health Affairs
Global studies in Health Affairs' March issue
The March issue of Health Affairs, the leading journal of health policy, contains several studies about global health. A flattening budget coupled with growing service demand drove the UK's National Health Service to seek spending cumulative efficiency savings of 17 percent over four years beginning in 2011. Identifying ineffective, overused, or inappropriate procedures was largely left to the local commissioning organizations to implement. The authors identified six high-volume but low-value procedures.

Contact: Sue Ducat
sducat@projecthope.org
301-841-9962
Health Affairs

Public Release: 3-Mar-2015
Molecular Pharmacology
UC Davis scientists describe novel drug mechanism that fights brain cancer
Researchers at UC Davis have developed and characterized a molecule that interferes with the internal regulation of cancer cells, causing them to self-destruct.
National Institutes of Health, Neurological Sciences, UC Davis Research Investments in Science and Engineering, MIND Institute Intellectual and Developmental Disabilities Research Center

Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System

Showing releases 1101-1125 out of 1371.

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