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Showing releases 1101-1125 out of 1213.

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Public Release: 14-Aug-2014
Cancer Research
NSAIDs may lower breast cancer recurrence rate in overweight and obese women
Recurrence of hormone-related breast cancer was cut by half in overweight and obese women who regularly used aspirin or other nonsteroidal anti-inflammatory drugs, according to data published in Cancer Research, a journal of the American Association for Cancer Research.
NIH/National Cancer Institute, Department of Defense, Breast Cancer Research Program

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 14-Aug-2014
Cell
Genetic signal prevents immune cells from turning against the body
Salk scientists find a control signal for the immune system that could help treat autoimmune diseases and cancer.

Contact: Salk Communications
press@salk.edu
Salk Institute

Public Release: 14-Aug-2014
Cancer Research
Aspirin may slow recurrence in breast cancer patients
New findings published in the journal Cancer Research reveal some postmenopausal overweight breast cancer patients who use anti-inflammatory drugs like aspirin or ibuprofen have significantly lower breast cancer recurrence rates. Anti-inflammatory use reduced the recurrence of ERα positive breast cancer by 50 percent and extended patients' disease-free period by more than two years. Research was performed at the Cancer Therapy & Research Center at the University of Texas Health Science Center San Antonio and University of Texas Austin.
US Department of Defense, Breast Cancer Research Program, NIH/National Cancer Institute

Contact: Catherine Duncan
duncancl@uthscsa.edu
210-567-2570
University of Texas Health Science Center at San Antonio

Public Release: 13-Aug-2014
Science Translational Medicine
Bacterial biosurgery shows promise for reducing the size of inoperable tumors
Deep within most tumors lie areas that remain untouched by chemotherapy and radiation. These troublesome spots lack the blood and oxygen needed for traditional therapies to work, but provide the perfect target for a new cancer treatment using bacteria that thrive in oxygen-poor conditions. Now, researchers have shown that injections of a weakened version of one such anaerobic bacteria -- the microbe Clostridium novyi -- can shrink tumors in rats, pet dogs, and a human patient.
BioMed Valley Discoveries, Inc., Virginia and D.K. Ludwig Fund for Cancer Research, Maryland Cigarette Restitution Fund, Commonwealth Fund, Swim Across America, Burroughs Wellcome Career Award for Medical Scientists

Contact: Kim Bland, Ph.D.
mediacontact@biomed-valley.com
816-389-8848
Stowers Institute for Medical Research

Public Release: 13-Aug-2014
Nature Communications
Scientists make major breakthrough in understanding leukemia
Scientists from Queen Mary University of London have discovered mutations in genes that lead to childhood leukemia of the acute lymphoblastic type -- the most common childhood cancer in the world.

Contact: Charli Scouller
c.scouller@qmul.ac.uk
020-788-27943
Queen Mary, University of London

Public Release: 13-Aug-2014
Science Translational Medicine
Injected bacteria shrink tumors in rats, dogs and humans
A modified version of the Clostridium novyi (C. novyi-NT) bacterium can produce a strong and precisely targeted anti-tumor response in rats, dogs and now humans, according to a new report from Johns Hopkins Kimmel Cancer Center researchers.
BioMed Valley Discoveries Inc., Virginia and D.K. Ludwig Fund for Cancer Research, Maryland Cigarette Restitution Fund, Commonwealth Fund, Swim Across America, Burroughs Wellcome Career Award for Medical Scientists, Voices Against Brain Cancer

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 13-Aug-2014
Cancer Epidemiology, Biomarkers & Prevention
Exercise associated with reduced risk of breast cancer in African-American women
Regular exercise, including brisk walking, is associated with a decrease in the incidence of breast cancer in African American women. In a recently published study in Cancer Epidemiology, Biomarkers & Prevention, researchers from Boston University's Slone Epidemiology Center found strong evidence linking physical exercise to a lower rate of breast cancer in African-American women, a group in which previous evidence has been lacking.
NIH/National Cancer Institute

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center

Public Release: 13-Aug-2014
Cancer Epidemiology, Biomarkers & Prevention
Prostate Cancer Prevention Trial identifies men mostly likely to undergo challenging study procedure
Healthy men participating in the Prostate Cancer Prevention Trial who actively participate in all steps of the clinical trial are most likely to undergo a biopsy, according to a study published in Cancer Epidemiology, Biomarkers and Prevention -- a journal of the American Association for Cancer Research.

Contact: Katrina Burton
kburton@mdanderson.org
713-792-8034
University of Texas M. D. Anderson Cancer Center

Public Release: 13-Aug-2014
Nature Communications
NTU gene research promises better treatment procedures for children with leukemia
A research team led by Nanyang Technological University scientists have made a key finding which is expected to open up improved treatment possibilities for children suffering from leukemia.

Contact: Lester Kok
lesterkok@ntu.edu.sg
65-679-06804
Nanyang Technological University

Public Release: 12-Aug-2014
Nanoscale
'Trojan horse' treatment could beat brain tumors
A 'Trojan horse' treatment for an aggressive form of brain cancer, which involves using tiny nanoparticles of gold to kill tumor cells, has been successfully tested by scientists. The ground-breaking technique could eventually be used to treat glioblastoma multiforme, which is the most common and aggressive brain tumor in adults, and notoriously difficult to treat.

Contact: Tom Kirk
tdk25@cam.ac.uk
01-223-768-377
University of Cambridge

Public Release: 12-Aug-2014
JAMA
Flexible sigmoidoscopy screening reduces colorectal cancer incidence, rate of death
Among about 100,000 study participants, screening with flexible sigmoidoscopy resulted in a reduced incidence and rate of death of colorectal cancer, compared to no screening, according to a study in the Aug. 13 issue of JAMA.

Contact: Øyvind Holme, M.D.
oyvind.holme@sshf.no
The JAMA Network Journals

Public Release: 12-Aug-2014
Neoplasia
Hijacking the brain's blood supply: Tumor discovery could aid treatment
Dangerous brain tumors hijack the brain's existing blood supply throughout their progression, by growing only within narrow potential spaces between and along the brain's thousands of small blood vessels, new research shows for the first time.
NIH/National Institute of Neurological Diseases and Stroke

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 12-Aug-2014
Analyst
New analysis reveals tumor weaknesses
Epigenetic markers in cancer cells could improve patient treatment.
National Science Foundation, Burroughs Wellcome Fund, NIH/National Institute for Environmental Health Sciences, James H. Ferry Fund for Innovation

Contact: Andrew Carleen
acarleen@mit.edu
617-253-1682
Massachusetts Institute of Technology

Public Release: 12-Aug-2014
European Urology
Less radical procedures offer similar cancer control for kidney cancer patients
Needle-guided tumor destruction procedures offer near equivalent lengths of local cancer control compared to surgery for patients with small kidney cancer tumors, according to the results of a large study published in the journal European Urology. 'If validated, these data suggest that an update to clinical guidelines would be warranted,' says the study's lead author, R. Houston Thompson, M.D., a Mayo Clinic urologist.

Contact: Joe Dangor
newsbureau@mayo.edu
507-284-5005
Mayo Clinic

Public Release: 12-Aug-2014
Journal of Cancer Survivorship
Beating childhood cancer does not make survivors healthier adults
Having survived cancer as a child does not necessarily have a ripple effect that makes people lead a healthier lifestyle once they grow up.

Contact: Alexander K. Brown
alexander.brown@springer.com
212-620-8063
Springer Science+Business Media

Public Release: 11-Aug-2014
Proceedings of the National Academy of Sciences
Novel drug action against solid tumors explained
Researchers at UC Davis, City of Hope, Taipai Medical University and National Health Research Institutes in Taiwan have discovered how a drug that deprives the cells of a key amino acid specifically kills cancer cells.

Contact: Carole Gan
carole.gan@ucdmc.ucdavis.edu
916-734-9047
University of California - Davis Health System

Public Release: 11-Aug-2014
Cancer
US lung cancer rates vary by subtype, sex, race/ethnicity, and age
A new analysis confirms that US lung cancer rates are declining overall, but it also uncovers previously unrecognized trends related to cancer subtype, sex, race/ethnicity, and age.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
Wiley

Public Release: 11-Aug-2014
Proceedings of the National Academy of Sciences
Scientists demonstrate long-sought drug candidate can halt tumor growth
Scientists at The Scripps Research Institute have disrupted the function of MYC, a cancer regulator thought to be 'undruggable.' The researchers found that a credit card-like molecule they developed somehow moves in and disrupts the critical interactions between MYC and its binding partner.
Pfizer Inc., NIH/National Cancer Institute, The Skaggs Institute for Chemical Biology, Austrian Science Fund

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute

Public Release: 11-Aug-2014
Proceedings of the National Academy of Sciences
Aberrant mTOR signaling impairs whole body physiology
The protein mTOR is a central controller of growth and metabolism. Deregulation of mTOR signaling increases the risk of developing metabolic diseases such as diabetes, obesity and cancer. In the current issue of the journal Proceedings of the National Academy of Sciences, researchers from the Biozentrum of the University of Basel describe how aberrant mTOR signaling in the liver not only affects hepatic metabolism but also whole body physiology.

Contact: Olivia Poisson
olivia.poisson@unibas.ch
University of Basel

Public Release: 11-Aug-2014
JAMA Internal Medicine
Bisphosphonates for osteoporosis not associated with reduced breast cancer risk
An analysis of data from two randomized clinical trials finds that 3-4 years of treatment with bisphosphonates to improve bone density is not linked to reduced risk of invasive postmenopausal breast cancer.

Contact: Laura Kurtzman
Laura.Kurtzman@ucsf.edu
415-476-3163
The JAMA Network Journals

Public Release: 11-Aug-2014
Cancer Cell
CRI scientists pinpoint gene likely to promote childhood cancers
Researchers at the Children's Medical Center Research Institute at UT Southwestern have identified a gene that contributes to the development of several childhood cancers, in a study conducted with mice designed to model the cancers.

Contact: Randy Sachs
randel.sachs@childrens.com
214-456-1523
UT Southwestern Medical Center

Public Release: 11-Aug-2014
Technology
Focal blood-brain-barrier disruption with high-frequency pulsed electric fields
Novel method uses bursts of nanosecond duration electric pulses to open the blood-brain-barrier as a potential therapy for brain cancer and neurological disorders.
National Science Foundation, Golfers Against Cancer, Center for Biomolecular Imaging in the Wake Forest School of Medicine

Contact: Philly Lim
mllim@wspc.com
65-646-65775
World Scientific

Public Release: 11-Aug-2014
Leukemia
ASU-Mayo researchers use calcium isotope analysis to predict myeloma progression
A team of researchers from Arizona State University and Mayo Clinic is showing how a staple of Earth science research can be used in biomedical settings to predict the course of disease. The researchers tested a new approach to detecting bone loss in cancer patients by using calcium isotope analysis to predict whether myeloma patients are at risk for developing bone lesions, a hallmark of the disease.

Contact: Skip Derra
skip.derra@asu.edu
480-965-4823
Arizona State University

Public Release: 11-Aug-2014
Nature Chemistry
Synthetic molecule makes cancer self-destruct
Researchers from The University of Texas at Austin and five other institutions have created a molecule that can cause cancer cells to self-destruct by ferrying sodium and chloride ions into the cancer cells. These synthetic ion transporters, described this week in the journal Nature Chemistry, confirm a two-decades-old hypothesis that could point the way to new anticancer drugs while also benefitting patients with cystic fibrosis.
National Creative Research Initiative, Office of Basic Energy Sciences, Chemical Biology Research Center

Contact: Steve Franklin
sefranklin@mail.utexas.edu
512-232-3692
University of Texas at Austin

Public Release: 11-Aug-2014
Cancer Cell
Malaria medicine chloroquine inhibits tumor growth and metastases
A recent study by investigators at VIB and KU Leuven has demonstrated that chloroquine also normalizes the abnormal blood vessels in tumors. This blood vessel normalization results in an increased barrier function on the one hand -- thereby blocking cancer cell dissemination and metastasis -- and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.

Contact: Sooike Stoops
info@vib.be
32-924-46611
VIB (the Flanders Institute for Biotechnology)

Showing releases 1101-1125 out of 1213.

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