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Showing releases 1101-1125 out of 1364.

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Public Release: 12-Feb-2015
JAMA Oncology
Estimates of gastric, breast cancer risk in carriers of CDH1 gene mutations
More precise estimates of age-associated risks of gastric and breast cancer were derived for carriers of the CDH1 gene mutation, a cancer predisposing gene that is abnormal in families meeting criteria for clinically defined hereditary diffuse gastric cancer, according to a study published online by JAMA Oncology.

Contact: Jenn Currie
jenn.currie@bccancer.bc.ca
604-675-8106
The JAMA Network Journals

Public Release: 12-Feb-2015
5th International Conference on Innovative Approaches in Head and Neck Oncology (ICHNO)
New radiotracer helps avoid neck dissection in patients with early head and neck cancer
A new tracer can enable surgeons to make an accurate identification of the sentinel node -- the lymph node to which cancer spreads first -- and hence spare patients the post-operative complications that may be linked to the removal of a group of lymph nodes in the neck.
Navidea Biopharmaceuticals

Contact: Mary Rice
mary.rice@riceconseil.eu
European Society for Radiotherapy and Oncology (ESTRO)

Public Release: 12-Feb-2015
5th International Conference on Innovative Approaches in Head and Neck Oncology (ICHNO)
New research shows possibility of cure for HPV positive throat cancer patients
Researchers from Canada have shown for the first time that some patients with HPV positive oropharyngeal cancer can be cured, even after the disease has spread to other organs.

Contact: Mary Rice
mary.rice@riceconseil.eu
European Society for Radiotherapy and Oncology (ESTRO)

Public Release: 12-Feb-2015
JAMA Oncology
Cancer patients rarely demand unnecessary tests and treatments
Physicians often blame patient demands for contributing to high medical costs, however, a new Penn Medicine study involving more than 5,000 patient-clinician visits indicates that cancer patients rarely push for unnecessary tests and treatments from their health care providers.

Contact: Anna Duerr
anna.duerr@uphs.upenn.edu
215-349-8369
University of Pennsylvania School of Medicine

Public Release: 11-Feb-2015
Journal of Controlled Release
Heating targeted cancer drugs increases uptake in tumor cells
Manchester scientists have found that gentle heating of targeted nano-sized drug parcels more effectively in deliver them to tumor cells -- resulting in an improvement in survival rates.

Contact: Jamie Brown
Jamie.brown@manchester.ac.uk
44-016-127-58383
University of Manchester

Public Release: 11-Feb-2015
Nature Communications
One-two punch catches cancer cells in vulnerable state
Timing may be decisive when it comes to overcoming cancer's ability to evade treatment. By hitting breast cancer cells with a targeted therapeutic immediately after chemotherapy, researchers from Brigham and Women's Hospital were able to target cancer cells during a transitional stage when they were most vulnerable, killing cells and shrinking tumors in the lab and in pre-clinical models. The team reports its findings in Nature Communications on Feb. 11.
US Department of Defense, National Institutes of Health, American Lung Association, Indo-US Science and Technology Forum, American Cancer Society

Contact: Haley Bridger
hbridger@partners.org
617-525-6383
Brigham and Women's Hospital

Public Release: 11-Feb-2015
New England Journal of Medicine
Order matters: Sequence of genetic mutations determines how cancer behaves
The order in which genetic mutations are acquired determines how an individual cancer behaves, according to research from the University of Cambridge, published today in the New England Journal of Medicine.
Leukaemia and Lymphoma Research, Cancer Research UK, Kay Kendall Leukaemia Fund, NIHR Cambridge Biomedical Research Centre, Cambridge Experimental Cancer Medicine Centre, Leukemia & Lymphoma Society of America, Canadian Institutes of Health Research

Contact: Craig Brierley
craig.brierley@admin.cam.ac.uk
44-012-237-66205
University of Cambridge

Public Release: 11-Feb-2015
BMJ Open
A cancer false alarm could discourage people from checking out future symptoms
Cancer Research UK scientists have found that having a cancer false alarm could put people off checking out cancer symptoms they develop in the future.
Cancer Research UK

Contact: Liz Smith
liz.smith@cancer.org.uk
020-346-98300
Cancer Research UK

Public Release: 11-Feb-2015
New England Journal of Medicine
Education, not mandatory screening, best for women with dense breast tissue
Women with dense breast tissue are at increased risk of breast cancer. Dense breast tissue, generally defined as having more fibroglandular than fatty tissue, can make it more difficult for radiologists to detect cancer on screening mammography.

Contact: Jerry Berger
jberger@bidmc.harvard.edu
617-667-7308
Beth Israel Deaconess Medical Center

Public Release: 11-Feb-2015
PLOS ONE
Twelve-year study suggests procedures to prevent cervical cancer do not affect fertility
Common surgical procedures used to diagnose and treat precancerous cervical lesions do not decrease women's chances of becoming pregnant, according to a study that followed nearly 100,000 women for up to 12 years. To the contrary, researchers found that women who had one of these procedures were actually more likely to become pregnant than women who did not have a procedure. The new Kaiser Permanente study is published today in PLOS ONE.
GSK

Contact: Cyrus Hedayati
chedayati@golin.com
415-318-4377
Kaiser Permanente

Public Release: 11-Feb-2015
New England Journal of Medicine
Lenvatinib shows promise for patients with radioiodine-refractory thyroid cancer
In a pivotal Phase III study led by researchers at The University of Texas MD Anderson Cancer Center, the oral anti-angiogenic therapy lenvatinib has shown dramatic improvement in progression-free survival in patients with advanced radioiodine-refractory thyroid cancer.

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center

Public Release: 11-Feb-2015
Journal of the American Chemical Society
Unlikely pairing -- an antidepressant plus dye -- yields tumor-targeting tool
Scientists stitched together two unrelated molecules to create a drug that targets and suppresses prostate tumors in mice.
Daniel Tsai Family Fund, US Department of Defense, Boyd and Elise Welin Professorship, NIH/National Cancer Center Institute, Board of Governors Endowed Cancer Chair, Margaret E. Early Medical Research Trust Award

Contact: Robert Perkins
perkinsr@usc.edu
213-740-9226
University of Southern California

Public Release: 11-Feb-2015
Proceedings of the National Academy of Sciences
IU researcher identifies novel pathway that solid tumor cancer cells activate for growth
A common, yet previously undistinguished protein, which is elevated in many late-stage cancers, may play a strategic role in tumor growth through a non-conventional pathway, researchers at the Indiana University School of Medicine report.
NIH/National Cancer Institute, Riley Children's Foundation

Contact: Mary Hardin
mhardin@iu.edu
317-274-5456
Indiana University

Public Release: 11-Feb-2015
Immunity
Bacteria protect intestinal tumor model from being killed by immune cells
Bacteria that are commonly found in the mouth are often abundant in patients with colon cancer, but the potential role these microbes play in tumor development has not been clear. A study published by Cell Press Feb. 18 in the journal Immunity reveals that the oral pathogen Fusobacterium nucleatum protects a variety of tumor cells from being killed by immune cells. The findings could open new avenues for the treatment of cancer in human patients.

Contact: Joseph Caputo
jcaputo@cell.com
617-335-6270
Cell Press

Public Release: 11-Feb-2015
Journal of Psychosocial Oncology
Study: Young adult survivors most distressed after leukemia and lymphoma treatment
45 percent of young adult leukemia and lymphoma survivors report moderate-to-high distress, whereas only 18 percent of older patients report similarly elevated levels.
National Institutes of Health, NIH/National Cancer Institute

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Anschutz Medical Campus

Public Release: 11-Feb-2015
Science Translational Medicine
Revolutionary new probe zooms in on cancer cells
Brain cancer patients may live longer thanks to a new cancer-detection method developed by researchers at the Montreal Neurological Institute and Hospital - The Neuro, at McGill University and the McGill University Health Center, and Polytechnique Montréal. The collaborative team has created a powerful new intraoperative probe for detecting cancer cells. The hand-held Raman spectroscopy probe enables surgeons, for the first time, to accurately detect virtually all invasive brain cancer cells in real time during surgery.

Contact: Anita Kar
anita.kar@mcgill.ca
514-398-3376
McGill University

Public Release: 11-Feb-2015
Nature Communications
Study finds new lethal combination of cancer drugs shrinks tumors
Controlling the time and sequence of cancer therapies may hold the key to unlocking better outcomes for patients with aggressive cancers, according to research published today. In a collaborative effort between cancer biologists at Harvard Medical School and applied mathematicians at the University of Waterloo, researchers are now showing that improved cancer therapy can be achieved by targeting drug-resistant cancer cells in a new way.

Contact: Nick Manning
nmanning@uwaterloo.ca
226-929-7627
University of Waterloo

Public Release: 10-Feb-2015
Journal of Clinical Oncology
Smaller pre-surgery radiation targets reduces long term side effects, not survival rates
The Journal of Clinical Oncology just published clinical trial results that more firmly establish that for patients with soft tissue sarcomas, image-guided radiation directed towards a smaller target area great reduced long term negative impact without effecting survival rates.
NRG Oncology

Contact: Charles Jolie
Charles_L_Jolie@Rush.edu
312-942-7817
Rush University Medical Center

Public Release: 10-Feb-2015
British Journal of Cancer
90 percent approve of cancer screening but screening uptake is lower
Nine in 10 people think that cancer screening is 'almost always a good idea' despite the fact that screening uptake is lower, a Cancer Research UK study in the British Journal of Cancer shows.

Contact: Emily Head
emily.head@cancer.org.uk
020-346-96189
Cancer Research UK

Public Release: 10-Feb-2015
Addiction
Plain packaging reduces 'cigarette-seeking' response by almost 10 percent, says study
Plain tobacco packaging may reduce the likelihood of smokers seeking to obtain cigarettes by almost 10 percent compared to branded packs, according to research from the universities of Exeter and Bristol.
British Heart Foundation, Cancer Research UK, Economic and Social Research Council, Medical Research Council, National Institute for Health Research

Contact: Eleanor Gaskarth
e.f.gaskarth@hotmail.com
44-078-794-33087
University of Exeter

Public Release: 10-Feb-2015
Developmental Cell
Epigenetic breakthrough: A first of its kind tool to study the histone code
University of North Carolina scientists have created a new research tool, based on the fruit fly, to help crack the histone code. This research tool can be used to better understand the function of histone proteins, which play critical roles in the regulation of gene expression in animals and plants.
National Institutes of Health, University of North Carolina

Contact: Mark Derewicz
mark.derewicz@unchealth.unc.edu
919-923-0959
University of North Carolina Health Care

Public Release: 10-Feb-2015
Journal of Thoracic Oncology
Mesothelioma in southern Nevada likely result of asbestos in environment
Malignant mesothelioma has been found at higher than expected levels in women and in individuals younger than 55 years old in the southern Nevada counties of Clark and Nye, likewise in the same region carcinogenic mineral fibers including actinolite asbestos, erionite, winchite, magnesioriebeckite and richterite were discovered. These data suggest that these elevated numbers of malignant mesothelioma cases are linked to environmental exposure of carcinogenic mineral fibers.

Contact: Murry Wynes
Murry.Wynes@iaslc.org
720-325-2945
International Association for the Study of Lung Cancer

Public Release: 10-Feb-2015
Stem Cell Reports
New reporter system to study bone-related regenerative medicine generated by UMN labs
A new reporter system used to study the bone regeneration potential of human embryonic stem cells has been generated in research led by the University of Minnesota. The new reporter system is the first of its kind for human pluripotent stem cells and is important for identifying certain agents and pathways that mediate early stages of human bone development. The research is published today in the journal Stem Cell Reports.

Contact: Miranda Taylor
tayl0551@umn.edu
612-626-2767
University of Minnesota Academic Health Center

Public Release: 10-Feb-2015
Journal of Thoracic Oncology
The NELSON lung cancer screening trial results are inferable for the general high-risk
Results of the NELSON lung cancer screening trial using low dose computed tomography can be used to predict the effect of population-based screening on the Dutch population even though there were slight differences in baseline characteristics of participants in the control arm versus eligible non-participants.

Contact: Murry Wynes
Murry.Wynes@iaslc.org
720-325-2945
International Association for the Study of Lung Cancer

Public Release: 10-Feb-2015
Journal of Thoracic Oncology
Not all EGFR mutations are the same when it comes to therapy for NSCLC
Certain rare epidermal growth factor receptor mutations are associated with tobacco smoking, worse prognosis and poor response to EGFR tyrosine kinase inhibitor therapy compared to the more common 'classical' EGFR mutations. However, as not all rare mutations are the same, testing and therapy may need to be evaluated for each individual mutation.

Contact: Murry Wynes
Murry.Wynes@iaslc.org
720-325-2945
International Association for the Study of Lung Cancer

Showing releases 1101-1125 out of 1364.

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