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Showing releases 1101-1125 out of 1299.

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Public Release: 18-Jun-2015
Genomic discovery of skin cancer subtypes provides potential 'signpost' for drug targets
Cutaneous melanoma, the most deadly form of skin cancer, is now believed to be divided into four distinct genomic subtypes, say researchers at The University of Texas MD Anderson Cancer Center, a finding that could prove valuable in the ever-increasing pursuit of personalized medicine.

Contact: Ron Gilmore
University of Texas M. D. Anderson Cancer Center

Public Release: 18-Jun-2015
A single gene turns colorectal cancer cells back into normal tissue in mice
Anti-cancer strategies generally involve killing off tumor cells. However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study published June 18 in the journal Cell. Researchers found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only four days.

Contact: Joseph Caputo
Cell Press

Public Release: 18-Jun-2015
Journal of the National Cancer Institute
Tubal ligation may improve the prognosis of endometrial cancer later in life
Endometrial cancer (EC) can spread by several routes, including the lymph system, blood vessels, through the uterine wall, as well as through the fallopian tubes into the peritoneal cavity, but the association of transtubal dissemination of EC with cancer stage, histological type, and mortality is unknown.

Contact: Zachary Rathner
Oxford University Press USA

Public Release: 18-Jun-2015
Single enzyme's far-reaching influence in human biology and disease
Researchers at University of California, San Diego School of Medicine have made a surprisingly simple discovery: The modification of more than 100 secreted proteins is the work of a single enzyme called Fam20C. The finding is published June 18 by Cell.
National Institutes of Health, Welch Foundation, AIRC

Contact: Heather Buschman
University of California - San Diego

Public Release: 18-Jun-2015
Cell Metabolism
Diet that mimics fasting appears to slow aging
Study shows broad health benefits from periodic use of diet that mimics fasting in mice and yeast -- which appear to translate to humans, also.
NIH/National Institute on Aging

Contact: Robert Perkins
University of Southern California

Public Release: 18-Jun-2015
Specific roles of adult neural stem cells may be determined before birth
Adult neural stem cells, which are commonly thought of as having the ability to develop into many type of brain cells, are in reality pre-programmed before birth to make very specific types of neurons, at least in mice, according to a study led by UC San Francisco researchers.
National Institutes of Health, John G. Bowes Research Fund, Howard Hughes Medical Institute

Contact: Laura Kurtzman
University of California - San Francisco

Public Release: 18-Jun-2015
JAMA Oncology
Parkinson's disease appears associated with many cancers in Taiwan
Parkinson's disease appeared associated with 16 types of cancer in a study in Taiwan, an effort to explain the association in an East Asian population because most prior research has been conducted in Western populations, according to an article published online by JAMA Oncology.

Contact: Pan-Chyr Yang, M.D., Ph.D.
The JAMA Network Journals

Public Release: 18-Jun-2015
TSRI research leads to 3-D structures of key molecule implicated in diseases of the brain
Scientists at the Scripps Research Institute have teamed up with several other institutions and pharmaceutical companies, to publish the first 3-D structures of a receptor implicated in many diseases of the brain and in normal physiology throughout the body. Surprisingly, the structures revealed a new understanding of the body's use of cannabinoids -- a naturally produced substance chemically related to marijuana.
National Institutes of Health, Ono Pharmaceutical Co. Ltd.

Contact: Madeline McCurry-Schmidt
Scripps Research Institute

Public Release: 18-Jun-2015
Study: Abdominal blood clots may indicate undiagnosed cancer
New research published online today in Blood, the Journal of the American Society of Hematology, concludes that a blood clot in an abdominal vein may be an indicator of undiagnosed cancer. The study also suggests that these clots predict poorer survival in patients with liver and pancreatic cancer.

Contact: Amanda Szabo
American Society of Hematology

Public Release: 18-Jun-2015
Nature Communications
Faster, not stronger: How a protein regulates gene expression
By measuring the motion of single molecules, EPFL scientists have discovered how specialized proteins control gene expression by binding and compacting discrete parts of DNA inside the cell. The findings have significant implications for genetics and cancer research.
Sandoz Family Foundation, Swiss National Science Foundation, École Polytechnique Fédérale de Lausanne

Contact: Nik Papageorgiou
Ecole Polytechnique Fédérale de Lausanne

Public Release: 17-Jun-2015
JAMA Surgery
Breast-conserving therapy for early-stage cancers has increased, though access an issue
The first comprehensive national review of breast-conserving therapy (BCT) shows that over the last 13 years rates of this treatment modality for early-stage breast cancer have increased at a steady pace. However, the review also highlights important demographic factors that impact which patients have access to BCT.

Contact: Laura Sussman
University of Texas M. D. Anderson Cancer Center

Public Release: 17-Jun-2015
Science Translational Medicine
New imaging technique could make brain tumor removal safer, more effective, study suggests
Brain surgery is famously difficult for good reason: when removing a tumor, for example, neurosurgeons walk a tightrope as they try to take out as much of the cancer as possible while keeping crucial brain tissue intact -- and visually distinguishing the two is often impossible. Now researchers report they have developed an imaging technology that could provide surgeons with a color-coded map of a patient's brain showing which areas are and are not cancer.
NIH/National Institute of Biomedical Imaging and Bioengineering, NIH/National Institute of Neurological Disorders and Stroke, NIH/National Cancer Institute, Coulter Foundation

Contact: Shawna Williams
Johns Hopkins Medicine

Public Release: 17-Jun-2015
Nature Immunology
Restoring natural immunity against cancers
Scientists at the Institut Pasteur and Inserm have successfully increased the infiltration of immune cells into tumors, thus inducing the immune system to block tumor growth. In an article published in Nature Immunology, the scientists show that, in combination with existing immunotherapies, this process efficiently destroys cancer cells.
Pasteur-Roux Grant, French Cancer League, Fondation ARC Cancer Research Organization, French National Research Agency

Contact: Myriam Rebeyrotte
Institut Pasteur

Public Release: 17-Jun-2015
New biomarkers might help personalize metastatic colorectal cancer treatment
Metastatic colorectal cancer patients tend to live longer when they respond to the first line of chemotherapy their doctors recommend. To better predict how patients will respond to chemotherapy drugs before they begin treatment, researchers at University of California, San Diego School of Medicine conducted a proof-of-principle study with a small group of metastatic colorectal cancer patients. The results revealed two genes that could help physicians make more informed treatment decisions for patients with this disease.
Arthur Athans in the name of his wife, Barbara Mae Athans, National Institutes of Health, Marsha Rivkin Center for Ovarian Cancer Research and Conquer Cancer Foundation of ASCO

Contact: Heather Buschman
University of California - San Diego

Public Release: 17-Jun-2015
The Journal of Urology
Vanderbilt-led study finds significant drop in new prostate cancer diagnoses
A new study led by Vanderbilt University Medical Center investigators found new diagnoses of prostate cancer in the US declined 28 percent in the year following the draft recommendation from the United States Preventive Services Task Force (USPSTF) against routine PSA screening for men.

Contact: Craig Boerner
Vanderbilt University Medical Center

Public Release: 17-Jun-2015
Molecular Cell
Discovery may lead to targeted melanoma therapies
Melanoma patients with high levels of a protein that controls the expression of pro-growth genes are less likely to survive, according to a new study.

Contact: Lucia Lee
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 17-Jun-2015
Cancer Discovery
Tests to gauge genetic risks for prostate cancer now are feasible
Men with an elevated, genetically inherited risk for prostate cancer could be routinely identified with a simple blood or urine test, scientists at UC San Francisco and Kaiser Permanente Northern California have concluded, potentially paving the way to better or earlier diagnosis. The study, which included 7,783 men with prostate cancer and 38,595 without the disease, is available online and will be published in an upcoming issue of the journal Cancer Discovery.
National Institutes or Health, Robert Wood Johnson Foundation, Wayne and Gladys Valley Foundation, Ellison Medical Foundation

Contact: Peter Farley
University of California - San Francisco

Public Release: 16-Jun-2015
Device allows evaluation of the efficacy, toxicity of drugs metabolized through the liver
Researchers from the Massachusetts General Hospital Center for Engineering in Medicine have developed a novel approach that dramatically simplifies the evaluation of the liver's drug-metabolizing activity and the potential toxic effects of the products of that activity on other organs.
National Institutes of Health

Contact: Noah Brown
Massachusetts General Hospital

Public Release: 16-Jun-2015
Cancer Research
Protein plays key role in spread of breast cancer
For breast cancer to be fatal, the tumor has to send out metastases to other parts of the body. The cancer cells are spread via the blood vessels, and a research team at Lund University in Sweden has now proven that the protein ALK1 determines the extent of the tumor's spread in the body. The higher the levels of the protein on the surface of the blood vessels, the greater their permeability to tumor cells and therefore the greater the risk of metastases.

Contact: Kristian Pietras
Lund University

Public Release: 16-Jun-2015
Returning killer T cells back to barracks could improve vaccines
Just as militaries need to have trained, experienced soldiers ready for future wars, making sure that the immune system has enough battle-ready T cells on hand is important for fast-acting, more effective vaccines, according to Penn State researchers.
National Institutes of Health, US Department of Agriculture, American Association of Immunologists

Contact: Matt Swayne
Penn State

Public Release: 16-Jun-2015
Cell Stem Cell
Researchers identify new stem cell population important in the growth of colon cancer
Researchers at Lawson Health Research Institute have identified a previously unknown, long-lived radiation-resistant stem cell population in the colon. Most importantly, they also found that these stem cells can give rise to colonic tumors and sustain their growth. The findings, which are published in the prominent journal Cell Stem Cell, will significantly change the way we study and treat colon cancer.

Contact: Julia Capaldi
519-685-8500 x75616
Lawson Health Research Institute

Public Release: 16-Jun-2015
New study discovers potential target for tissue regeneration
A new study co-led by Hsin-Hsiung Tai, professor of pharmaceutical sciences at the University of Kentucky, suggests that a key prostaglandin metabolic enzyme shows promise as a drug target to help tissue regeneration and repair, particularly after bone marrow transplantation and tissue injuries.

Contact: Allison Perry
University of Kentucky

Public Release: 16-Jun-2015
European Conferences on Biomedical Optics 2015
Journal of Biomedical Optics
Journal article details 'multiplicity of barriers' to clinical acceptance of medical laser innovations
An article published today in the Journal of Biomedical Optics details obstacles along the path from idea to clinical use of life-saving new medical laser applications. The article appears in a special section titled 'Light for Life' celebrating the International Year of Light and Light-based Technologies 2015 and paralleling a dedicated session at the at the European Conference on Biomedical Optics running June 21-25 in Munich.

Contact: Amy Nelson
SPIE--International Society for Optics and Photonics

Public Release: 16-Jun-2015
Journal of Clinical Oncology
Lymph nodes signal more aggressive thyroid cancer even in young patients
Researchers at the Duke Cancer Institute and the Duke Clinical Research Institute have found that younger thyroid cancer patients with lymph node involvement are also at increased risk of dying, contrary to current beliefs and staging prognostic tools that classify young patients as having low-risk disease.

Contact: Sarah Avery
Duke University Medical Center

Public Release: 16-Jun-2015
Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research
Drug trials in pet dogs with cancer may speed advances in human oncology
Pet dogs may be humans' best friends in a new arena of life: cancer treatment, said University of Illinois veterinary clinical medicine professor Timothy Fan. Physiological similarities between dogs and humans, and conserved genetics between some dog and human cancers, can allow pet dogs to serve as useful models for studying new cancer drugs, he said.

Contact: Diana Yates
University of Illinois at Urbana-Champaign

Showing releases 1101-1125 out of 1299.

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