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Showing releases 1101-1125 out of 1324.

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Public Release: 23-Dec-2014
Science Signaling
Researchers map paths to cancer drug resistance
A team of researchers led by Duke Cancer Institute has identified key events that prompt certain cancer cells to develop resistance to otherwise lethal therapies.
National Institutes of Health

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

Public Release: 23-Dec-2014
JAMA Dermatology
Trends in indoor tanning among us high school students
While indoor tanning has decreased among high school students, about 20 percent of females engaged in indoor tanning at least once during 2013 and about 10 percent of girls frequently engaged in the practice by using an indoor tanning device 10 or more times during the year, according to a research letter published online by JAMA Dermatology.

Contact: Brittany Behm
media@cdc.gov
404-639-3286
The JAMA Network Journals

Public Release: 23-Dec-2014
PLOS Biology
CNIO researchers activate hair growth by modifying immune cells
How to restore hair loss is a task not undertaken exclusively by beauty practitioners. The discovery, now published by a group from the Spanish National Cancer Research Centre, reveals a novel angle to spur hair follicle growth. This also adds new knowledge to a broader problem: how to regenerate tissues in an adult organism, especially the skin.

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 23-Dec-2014
EBioMedicine
Researchers confirm whole-genome sequencing can successfully identify cancer-related mutations
UT Southwestern Medical Center cancer researchers have demonstrated that whole-genome sequencing can be used to identify patients' risk for hereditary cancer.

Contact: Lori Sundeen Soderbergh
lori.soderbergh@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 23-Dec-2014
Clinical Cancer Research
Armed virus shows promise as treatment for pancreatic cancer
A new combination of two different approaches -- virotherapy and immunotherapy -- is showing 'great promise' as a treatment for pancreatic cancer, according to new research from Queen Mary University of London.
Pancreatic Cancer Research Fund

Contact: Maggie Blanks
maggieblanks@pcrf.org.uk
44-020-836-01119
Pancreatic Cancer Research Fund

Public Release: 22-Dec-2014
Lancet Haematology
Test predicts response to treatment for complication of leukemia stem cell treatment
A new test may reveal which patients will respond to treatment for graft versus host disease (GVHD), an often life-threatening complication of stem cell transplants (SCT) used to treat leukemia and other blood disorders, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and published online today in the journal Lancet Haematology and in print in the January issue.
NIH/National Cancer Institute, NIH/National Heart Lung and Blood Institute, NIH/National Institute of Allergy and Infectious Diseases, Doris Duke Charitable Fund, American Cancer Society, Judith Devries Fund

Contact: Lucia Lee
lucia.lee@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 22-Dec-2014
Cancer
Bone loss drugs may help prevent endometrial cancer
A new analysis suggests that women who use bisphosphonates -- medications commonly used to treat osteoporosis and other bone conditions -- have about half the risk of developing endometrial cancer as women who do not use the drugs.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
Wiley

Public Release: 22-Dec-2014
Journal of Biological Chemistry
Blocking excessive division of cell powerhouses reduces liver cell death in cholestasis
The power plants that fuel liver cells rapidly splinter when exposed to bile salts that aid digestion, prompting cell death, but blocking this excessive fission appears to protect the liver, scientists report.
National Institutes of Health

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University

Public Release: 22-Dec-2014
Nature Communications
Researchers discover new genetic anomalies in lung cancer
By analyzing the DNA and RNA of lung cancers, researchers at the University of Michigan Comprehensive Cancer Center found that patients whose tumors contained a large number of gene fusions had worse outcomes than patients with fewer gene fusions. In addition, the researchers identified several new genetic anomalies that occur in lung cancer, including in patients with a history of smoking.
NIH/National Cancer Institute, Dermatology Foundation, Spanish Society of Medical Oncology Fellowship, China Scholarship Council Award, National Science Foundation

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 22-Dec-2014
Nature
Scientists uncover new, fundamental mechanism for how resveratrol provides health benefits
Scientists at the Scripps Research Institute have found that resveratrol, the red-wine ingredient once touted as an elixir of youth, powerfully activates an evolutionarily ancient stress response in human cells. The finding should dispel much of the mystery and controversy about how resveratrol really works.
NIH/National Cancer Institute, National Foundation for Cancer Research, Tyr Pharma Inc.

Contact: Madeline McCurry-Schmidt
madms@scripps.edu
858-784-9254
Scripps Research Institute

Public Release: 22-Dec-2014
Cancer Research
Suppressing a protein reduces cancer spread in mice
In a new study, researchers found that a specific protein called 'chitinase 3-like-1' appears key in enabling malignant melanoma or breast cancer to spread to the lungs of mice. Decreasing its levels or blocking the protein dramatically reduced that spread.
National Institutes of Health

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

Public Release: 22-Dec-2014
PLOS ONE
University of Louisville faculty discover mutation role involved in 75 percent of glioblastomas, melanomas
Researchers at the University of Louisville's James Graham Brown Cancer Center have identified for the first time mutations that destabilize a DNA structure that turns a gene off. These mutations occur at four specific sites in what is known as the 'hTERT promoter' in more than 75 percent of glioblastomas and melanomas.

Contact: Jill Scoggins
jill.scoggins@louisville.edu
502-852-7461
University of Louisville

Public Release: 22-Dec-2014
Biophysical Journal
Penn researchers model the mechanics of cells' long-range communication
Interdisciplinary research at the University of Pennsylvania is showing how cells interact over long distances within fibrous tissue, like that associated with many diseases of the liver, lungs and other organs.
National Institutes of Health, National Science Foundation

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania

Public Release: 22-Dec-2014
Neurosurgery
Limit imaging scans for headache? Neurosurgeons raise concerns
Recent guidelines seeking to reduce the use of neuroimaging tests for patients with headaches run the risk of missing or delaying the diagnosis of brain tumors, according to a special article in the January issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health

Public Release: 22-Dec-2014
Journal of Clinical Oncology
Risk for leukemia after treatment for early-stage breast cancer higher than reported
The risk of developing leukemia after radiation therapy or chemotherapy for early stage breast cancer remains very small, but it is twice as high as previously reported, according to results of a new study led by researchers at the Johns Hopkins Kimmel Cancer Center.
NIH/National Cancer Institute, Susan G. Komen for the Cure

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 19-Dec-2014
Cancer Cell
A polymorphism and the bacteria inside of us help dictate inflammation, antitumor activity
A common polymorphism can lead to a chain of events that dictates how a tumor will progress in certain types of cancer, including a form of breast cancer as well as ovarian cancer, according to new research from The Wistar Institute that was published online by the journal Cancer Cell. The research reveals a more explicit role about the symbiotic relationship humans have with the various bacteria that inhabit our body and their role during tumor progression.
Breast Cancer Alliance, Ovarian Cancer Research Fund

Contact: Ben Leach
bleach@wistar.org
215-495-6800
The Wistar Institute

Public Release: 18-Dec-2014
Cancer Cell
Scientists map out how childhood brain tumors relapse
Researchers have discovered the unique genetic paths that the childhood brain tumor medulloblastoma follows when the disease comes back
Cancer Research UK, Action Medical Research, Sparks, The Brain Tumour Charity, JGW Patterson Foundation, Christopher's Smile

Contact: Simon Shears
simon.shears@cancer.org.uk
44-203-469-8054
Cancer Research UK

Public Release: 18-Dec-2014
Cell Metabolism
A change of diet to unmask cancer vulnerabilities and reduce cancer risk
Many recent studies showed that calorie restrictions reduce the incidence of cancer, whereas high-calorie diets cause obesity and diabetes, both of which increase the risk of developing cancers. However, tumor biology still hides complex mechanisms, as revealed by researchers from the Faculty of Medicine of the University of Geneva, Switzerland. In a study published in Cell Metabolism, scientists not only found the unexpected benefit that a change of diet had on certain types of lung cancer, they also deciphered the molecular mechanism underlying this dietary effect and showed how this cancer vulnerability could be exploited in targeted treatment strategies with limited side effects.

Contact: Roberto Coppari
roberto.coppari@unige.ch
022-379-5539
Université de Genève

Public Release: 18-Dec-2014
Science
Machine learning reveals unexpected genetic roots of cancers, autism and other disorders
A Canadian research team led by professor Brendan Frey has developed the first method for 'ranking' genetic mutations based on how living cells 'read' DNA, revealing how likely any given alteration is to cause disease. They use a new 'machine learning' computational technique developed at the University of Toronto to discover unexpected genetic determinants of autism, hereditary cancers and spinal muscular atrophy, a leading genetic cause of infant mortality.
Canadian Institute for Advanced Research, Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, McLaughlin Centre, Autism Speaks, Genome Canada

Contact: RJ Taylor
rj.taylor@utoronto.ca
647-228-4358
University of Toronto Faculty of Applied Science & Engineering

Public Release: 18-Dec-2014
BJU International
Laparoscopic surgery for bladder cancer leads to good long-term cancer control
Long-term survival rates following laparoscopic surgery for bladder cancer are comparable to those of open surgery, according to a study published in BJU International.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
Wiley

Public Release: 18-Dec-2014
Aging
Mutations need help from aging tissue to cause leukemia
University of Colorado Cancer Center study published today in the journal Aging shows that in addition to DNA damage, cancer depends on the slow degradation of tissue that surrounds cancer cells, something that naturally comes with aging.

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

Public Release: 18-Dec-2014
Immunity
Cells identified that enhance tumor growth and suppress anti-cancer immune attack
A study led by St. Jude Children's Research Hospital scientists has identified the population of white blood cells that tumors use to enhance growth and suppress the disease-fighting immune system. The results, which appear in the Dec. 18 edition of the scientific journal Immunity, mark a turning point in cancer immunology and provide the foundation for developing more effective immunotherapies.
Hartwell Foundation, Alex's Lemonade Stand Foundation, NIH/National Cancer Institute, ALSAC

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Public Release: 18-Dec-2014
Cell Reports
Stem cells born out of indecision
Scientists at the University of Copenhagen have gained new insight into embryonic stem cells and how blocking their ability to make choices explains why they stay as stem cells in culture. The results have just been published in the scientific journal Cell Reports.

Contact: Joshua Brickman
joshua.brickman@sund.ku.dk
45-51-68-04-38
University of Copenhagen - The Faculty of Health and Medical Sciences

Public Release: 18-Dec-2014
Nature Medicine
Mutations prevent programmed cell death
Programmed cell death is a mechanism that causes defective and potentially harmful cells to destroy themselves. It serves a number of purposes in the body, including the prevention of malignant tumor growth. Now, researchers at Technische Universität München have discovered a previously unknown mechanism for regulating programmed cell death. They have also shown that patients with lymphoma often carry mutations in this signal pathway.

Contact: Vera Siegler
vera.siegler@tum.de
49-892-892-2731
Technische Universitaet Muenchen

Public Release: 18-Dec-2014
Nature Communications
Researchers ferret out a flu clue
For the first time it has been shown that ferrets share a mutation that was previously thought to be unique to humans, among the mammals. This helps to explain why the molecular characteristics of ferrets so uniquely mimic human susceptibility, severity and transmission of influenza A virus strains. These findings could pave the way to a completely novel approach to tackling human diseases from influenza through to cancer.

Contact: Helen Wright
helen.wright@griffith.edu.au
047-840-6565
Griffith University

Showing releases 1101-1125 out of 1324.

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