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Showing releases 1101-1125 out of 1321.

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Public Release: 2-Apr-2015
Nature Communications
Key mechanism identified in tumor-cell proliferation in pediatric bone cancers
A particular molecular pathway permits stem cells in pediatric bone cancers to grow rapidly and aggressively, according to researchers at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center.

Contact: David March
NYU Langone Medical Center / New York University School of Medicine

Public Release: 2-Apr-2015
An 'evolutionary relic' of the genome causes cancer
Pseudogenes have long been considered 'genomic junk,' mysterious remnants of evolution. Now, a scientific team in the Cancer Research Institute at Beth Israel Deaconess Medical Center has found that one of these evolutionary relics caused the development of an aggressive cancer in an animal model -- suggesting the need to sequence this vast genomic 'dark matter' in pursuit of precision cancer therapies.
National Institutes of Health, DOD Prostate Cancer Research Program, American Cancer Society, Cancer Research UK, Wellcome Trust, International Assn. for Cancer Research, Italian Assn. for Cancer Research, German Academy of Sciences Leopoldina

Contact: Bonnie Prescott
Beth Israel Deaconess Medical Center

Public Release: 1-Apr-2015
Genes & Development
A CNIO team succeeds in doubling the life span of mice suffering from premature aging
An increase in the capacity to produce nucleotides, the 'building blocks' of DNA, reduces genome fragility and counteracts premature aging in mutant mice for the ATR protein. The experiments may explain the beneficial effects of folic acid, a precursor of nucleotides, which are clinically used to alleviate the degenerative symptoms associated with aging.

Contact: Nuria Noriega
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 1-Apr-2015
Scientists drill down to genetic root of prostate tumor development
Scientists have revealed the root of prostate cancers in individual men, discovering that despite huge genetic variety between tumors they also share common gene faults -- insight that could offer new treatment hopes.

Contact: Emily Head
Cancer Research UK

Public Release: 1-Apr-2015
Cancer Epidemiology, Biomarkers & Prevention
Number of childhood cancer survivors increasing, most have morbidities
The prevalence of childhood cancer survivors is estimated to have increased, and the majority of those who have survived five or more years beyond diagnosis may have at least one chronic health condition.
National Institutes of Health

Contact: Lauren Riley
American Association for Cancer Research

Public Release: 1-Apr-2015
PLOS Pathogens
Anticancer drug can spur immune system to fight infection
Imatinib, an example of a 'targeted therapy' against cancer, or related drugs might be tools to fight a variety of infections.
NIH/National Institute of Allergy and Infectious Diseases, NIH/National Heart, Lung, and Blood Institute

Contact: Quinn Eastman
Emory Health Sciences

Public Release: 1-Apr-2015
Science Translational Medicine
New knowledge on EphB signaling may improve treatment of intestinal cancers
A new study led by researchers at Sweden's Karolinska Institutet and Nanyang Technological University in Singapore, provides experimental evidence that a drug that inhibits the EphB-signaling pathway in the cell effectively can suppress the development of intestinal tumors.
Swedish Research Council, Swedish Cancer Society, Karolinska Institutet, Tobias Foundation, Knut and Alice Wallenberg Foundation, Torsten Söderberg Foundation, Singapore Millennium Foundation

Contact: KI Press Office
Karolinska Institutet

Public Release: 1-Apr-2015
Cancer Epidemiology, Biomarkers & Prevention
Cancer prevention efforts in the US a mixed bag
While there has been substantial progress in some cancer control efforts in the past several decades, like reductions in smoking and increased utilization of cancer screening, progress in some areas is lagging, according to a new report.
American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 1-Apr-2015
Science Translational Medicine
Cancer's relentless evolution
In new research, Carlo Maley, Ph.D., and his colleagues describe compulsive evolution and dramatic genetic diversity in cells belonging to one of the most treatment-resistant and lethal forms of blood cancer: acute myeloid leukemia (AML). The authors suggest the research may point to new paradigms in both the diagnosis and treatment of aggressive cancers, like AML.

Contact: joseph Caspermeyer
Arizona State University

Public Release: 1-Apr-2015
BMC Veterinary Research
Old cancer drug could have new use in fighting cancer
Jeffrey Bryan, an associate professor of oncology at the MU College of Veterinary Medicine, found that an old cancer drug can not only kill cancer cells, but also works to change how certain cancer cells function, weakening those cells so they can be killed by other drugs.

Contact: Nathan Hurst
University of Missouri-Columbia

Public Release: 1-Apr-2015
Locking up an oncogenic transcription
A novel molecule designed by scientists at the University of Massachusetts Medical School and the University of Virginia inhibits progression of a hard-to-treat form of recurring acute myeloid leukemia in patient tissue. The small molecule is one of the first designed to specifically target a cancer-causing transcription factor.

Contact: Jim Fessenden
University of Massachusetts Medical School

Public Release: 1-Apr-2015
Study affirms lethal prostate cancer can spread from other metastatic sites
A new genomic analysis of tissue from patients with prostate cancer has added more evidence that cells within metastases from such tumors can migrate to other body parts and form new sites of spread on their own.
Cancer Research UK, Academy of Finland, Cancer Society of Finland, PELICAN Autopsy Study, Johns Hopkins Brady Urological Institute, John and Kathe Dyson, NIH/National Cancer Institute

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 1-Apr-2015
BMJ Open
Older people at higher risk of emergency cancer diagnosis
People over 60 are at higher risk of being diagnosed with lung or bowel cancer as an emergency in hospital than younger people, according to a Cancer Research UK-supported report, published today by BMJ Open.
Part-funded by Cancer Research UK

Contact: Liz Smith
Cancer Research UK

Public Release: 31-Mar-2015
Nature Communications
Scientists reveal unique mechanism of natural product with powerful antimicrobial action
Scientists from the Florida campus of The Scripps Research Institute have uncovered the unique mechanism of a powerful natural product with wide-ranging antifungal, antibacterial, anti-malaria and anti-cancer effects. The new study sheds light on the natural small molecule known as borrelidin.
National Institutes of Health, Korean Global Frontier Project, and PGA Women's Cancer Awareness Foundation

Contact: Eric Sauter
Scripps Research Institute

Public Release: 31-Mar-2015
St. Gallen 2015: Latest multidisciplinary research in early breast cancer
The latest challenges of early breast cancer research include refining classification and predicting treatment responses, according to a report on the 14th St. Gallen International Breast Cancer Consensus Conference, published in ecancermedicalscience.

Contact: Katie Foxall

Public Release: 31-Mar-2015
Journal of Public Health Management and Practice
How did he do it? Mayor Bloomberg's public health strategy evaluated in Journal of Public Health Management and Practice
How did former New York City Mayor Michael Bloomberg succeed in achieving so much of his 'comprehensive and far-reaching' public health agenda? Key strategies included harnessing the full authority of the City health department and mobilizing the existing workforce to focus on targeted reforms, according to a study in the March/April issue of the Journal of Public Health Management and Practice. The journal is published by Wolters Kluwer.

Contact: Connie Hughes
Wolters Kluwer Health

Public Release: 30-Mar-2015
Nature Methods
High-tech method allows rapid imaging of functions in living brain
Researchers studying cancer and other invasive diseases rely on high-resolution imaging to see tumors and other activity deep within the body's tissues. Using a new high-speed, high-resolution imaging method, Lihong Wang, Ph.D., and his team at Washington University in St. Louis were able to see blood flow, blood oxygenation, oxygen metabolism and other functions inside a living mouse brain at faster rates than ever before.
National Institutes of Health, National Science Foundation

Contact: Julie Flory
Washington University in St. Louis

Public Release: 30-Mar-2015
Experimental Biology 2015
New findings support the benefits of eating walnuts on overall health
Multiple new research abstracts suggest walnuts may have the potential to positively affect several important health factors. From their impact on colon cancer and certain aspects of cognitive aging, to their positive effect on both gut health and vascular health, the research findings presented at Experimental Biology 2015 detail our latest understanding of walnuts' inner workings. Running March 28 through April 1 in Boston, this annual meeting attracts an international audience of over 14,000 leading research scientists and exhibitors.
California Walnuts

Contact: Erin Farkaly
Edelman Seattle

Public Release: 30-Mar-2015
Journal of Clinical Investigation
Panel predicts whether rare leukemia will respond to treatment
Patients with chronic myelomonocytic leukemia have limited treatment options, and those that exist are effective only in fewer than half of patients. Now, a new study identifies a panel of genetic markers that predicted which tumor samples would likely respond to treatment.
Leukemia and Lymphoma Society, Sass Foundation, NIH/National Cancer Institute, US Department of Defense, Josie Robertson Investigator Program, Damon Runyon Clinical Investigator Award, The Evans Foundation, The French National Cancer Institute, and others

Contact: Nicole Fawcett
University of Michigan Health System

Public Release: 30-Mar-2015
Journal of the National Cancer Institute
The CNIO identifies a new gene involved in hereditary neuroendocrine tumors
Mutations in the MDH2 gene, a key factor in cellular metabolism, are associated with the development of pheochromocytomas and paragangliomas, neuroendocrine tumors that affect the suprarenal and parathyroid glands, respectively. Up to 50 percent of patients inherit and/or transmit susceptibility to developing these tumors. The discovery will enable genetic diagnosis prior to the appearance of the disease.

Contact: Nuria Noriega
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 30-Mar-2015
Journal of Ultrasound in Medicine
Teens with breast lumps may be able to avoid invasive biopsy
If a lump is found in the breast of an adolescent girl, she often will undergo an excisional biopsy. However, breast cancer is rare in adolescents, and the vast majority of teenage breast lumps turn out to be benign masses that are related to hormones and often go away over time.

Contact: Nora Dudley
Loyola University Health System

Public Release: 30-Mar-2015
Fasting and less-toxic cancer drug may work as well as chemotherapy
Fasting and kinase inhibitors work together to starve cancer cells.
Associazione Italiana per la Ricerca sul Cancro, Seventh Framework project PANCREAS, Compagnia di San Paolo; the Fondazione Umberto Veronesi, University of Genoa

Contact: Robert Perkins
University of Southern California

Public Release: 30-Mar-2015
To stop cancer: Block its messages
Weizmann Institute scientists identify a potential drug molecule that stops cancer cells, but not healthy ones, from getting their 'mail.'

Contact: Yael Edelman
Weizmann Institute of Science

Public Release: 30-Mar-2015
Journal of Clinical Oncology
Low vitamin D linked to worse prognosis in type of non-Hodgkin lymphoma
A new study found that people with lower vitamin D levels prior to treatment for follicular lymphoma succumb to the disease or face relapse earlier than patients with sufficient vitamin D levels in their blood.
NIH/National Cancer Institute

Contact: Lydia Fernandez
University of Rochester Medical Center

Public Release: 30-Mar-2015
Nature Nanotechnology
Princess Margaret scientists convert microbubbles to nanoparticles
Biomedical researchers led by Dr. Gang Zheng at Princess Margaret Cancer Centre have successfully converted microbubble technology already used in diagnostic imaging into nanoparticles that stay trapped in tumors to potentially deliver targeted, therapeutic payloads.

Contact: Jane Finlayson
University Health Network

Showing releases 1101-1125 out of 1321.

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