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Public Release: 12-May-2014
Cancer
US cervical cancer rates higher than previously reported, especially among older women
Cervical cancer rates in the United States are higher than previously believed, particularly among 65- to 69-year-old women and African-American women, according to a study led by a researcher at the University of Maryland School of Medicine published in the journal Cancer. Current US cervical cancer screening guidelines do not recommend routine Pap smears for women over 65 if their prior test results have been normal.
NIH/National Cancer Institute, and others

Contact: Karen Warmkessel
kwarmkessel@umm.edu
41-032-889-194-104-04153
University of Maryland Medical Center

Public Release: 12-May-2014
Clinical Cancer Research
A form of immune therapy might be effective for multiple myeloma
A new study provides evidence that genetically modified immune cells might effectively treat multiple myeloma, a disease that remains incurable and will account for an estimated 24,000 new cases and 11,100 deaths in 2014. The researchers modified T lymphocytes to target a molecule called CS1, which is found on myeloma cells, and to kill the cells. The findings support testing the potential therapy in a clinical trial.
National Institutes of Health, Multiple Myeloma Opportunities for Research and Education

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Wexner Medical Center

Public Release: 12-May-2014
JAMA Internal Medicine
Resveratrol in red wine, chocolate, grapes not associated with improved health
The antioxidant resveratrol found in red wine, chocolate and grapes was not associated with longevity or the incidence of cardiovascular disease, cancer and inflammation.

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
The JAMA Network Journals

Public Release: 12-May-2014
JAMA Internal Medicine
Diets rich in antioxidant resveratrol fail to reduce deaths, heart disease or cancer
A study of Italians who consume a diet rich in resveratrol -- the compound found in red wine, dark chocolate and berries -- finds they live no longer than and are just as likely to develop cardiovascular disease or cancer as those who eat or drink smaller amounts of the antioxidant.
NIH/National Institute on Aging, NIH/National Heart, Lung and Blood Institute

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine

Public Release: 12-May-2014
Cancer
Current guidelines underestimate US cervical cancer incidence and older women's risk
Rates of cervical cancer in American women may be higher than previously thought, and the disease may arise most often at an age when adequately screened women are advised to stop getting screened. The findings come from a new study published early online in CANCER, a peer-reviewed journal of the American Cancer Society. The results should be taken into consideration when the national guidelines for cervical cancer screening are reviewed.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
201-748-6358
Wiley

Public Release: 12-May-2014
Breast Cancer Research and Treatment
Triple negative breast cancer, ethnicity, and socioeconomic status
An analysis of a large nationwide dataset finds that regardless of their socioeconomic status, black women were nearly twice as likely as white women to be diagnosed with triple-negative breast cancer, a subtype that has a poorer prognosis.
American Cancer Society

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society

Public Release: 11-May-2014
Proceedings of the National Academy of Sciences
Revealed:Protein's role in preventing heart muscle growth leading to heart failure
Hebrew University Faculty of Medicine researchers showed for the first time that the protein Erbin is an important brake that helps prevent pathological cardiac hypertrophy. They showed that damage to this protein leads to excess growth of heart muscle, a decrease in function, and severe pathological growth of heart muscle. Their research has implications for breast cancer treatment, as Erbin interacts with the receptor Her2/ErBb2, which is overexpressed in approximately 30 percent of breast cancers.
United States Binational Science Foundation, Israeli Academy of Science, and others

Contact: Dov Smith
dovs@savion.huji.ac.il
972-258-82844
The Hebrew University of Jerusalem

Public Release: 9-May-2014
Angewandte Chemie
New method sneaks drugs into cancer cells before triggering release
Biomedical engineering researchers have developed an anti-cancer drug delivery method that essentially smuggles the drug into a cancer cell before triggering its release. The method can be likened to keeping a cancer-killing bomb and its detonator separate until they are inside a cancer cell, where they then combine to destroy the cell.
National Institutes of Health

Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University

Public Release: 9-May-2014
Nature Communications
Properties of water at nanoscale will help to design innovative technologies
Scientists from Politecnico di Torino (Turin, Italy) and Houston Methodist Research Institute (Houston, USA) have just proposed on Nature Communications a novel understanding of unexpected water properties at the nanoscale in the close proximity of solid surfaces. More rationally designed contrast agents for improved Magnetic Resonance Imaging performances are the first applications of the discovery.

Contact: Tiziana Vitrano
relazioni.media@polito.it
Politecnico di Torino

Public Release: 9-May-2014
Nature Neuroscience
Discovery links rare, childhood neurodegenerative diseases to common problem in DNA repair
St. Jude Children's Research Hospital scientists studying two rare, inherited childhood neurodegenerative disorders have identified a new, possibly common source of DNA damage that may play a role in other neurodegenerative diseases, cancer and aging. The findings appear in the current issue of the scientific journal Nature Neuroscience.
NIH/National Cancer Institute, National Institutes of Health, Geoffrey Beene Foundation, Goodwin Foundation, University of Manitoba, CancerCare Manitoba, and others

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Public Release: 9-May-2014
Cell Reports
Scientists decode epigenetic mechanisms distinguishing stem cell function and blood cancer
Researchers at Dartmouth's Norris Cotton Cancer Center have published results from a study in Cell Reports that discovers a new mechanism that distinguishes normal blood stem cells from blood cancers.
National Institutes of Health, American Cancer Society, Gabriel's Angel Foundation

Contact: Donna Dubuc
Donna.M.Dubuc@Dartmouth.edu
603-653-3615
The Geisel School of Medicine at Dartmouth

Public Release: 9-May-2014
EMBO Molecular Medicine
Plugging leaky blood vessels to save vision
A new drug approach has been developed for safer clean-up of deformed blood vessels in the eye by a research team at the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital in Toronto.
Canadian Institutes of Health Research

Contact: Polly Thompson
pthompson@lunenfeld.ca
41-658-648-002-046
Lunenfeld-Tanenbaum Research Institute

Public Release: 8-May-2014
Molecular Cancer Research
New paper provides important insights into carcinoma-associated fibroblasts
A new paper by a team of researchers led by Zachary T. Schafer, Coleman Assistant Professor of Cancer Biology in the Department of Biological Sciences at the University of Notre Dame, offers important new insights into the role carcinoma-associated fibroblasts (CAFs) play in tumor biology. A number of recent studies have revealed CAFs to be a major contributor to tumor progression through a variety of mechanisms. Despite this information, the precise role CAFs play in augmenting the growth of tumors is still poorly understood.
V Foundation for Cancer Research

Contact: Zachary T. Schafer
zschafe1@nd.edu
574-631-0875
University of Notre Dame

Public Release: 8-May-2014
Journal of Clinical Oncology
Experimental antibody shows early promise for treatment of childhood tumor
Tumors shrank or disappeared and disease progression was temporarily halted in 15 children with advanced neuroblastoma enrolled in a safety study of an experimental antibody produced at St. Jude Children's Research Hospital.
National Institutes of Health, St. Baldrick's Foundation, ALSAC, and others

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital

Public Release: 8-May-2014
Immunity
Immune cells found to fuel colon cancer stem cells
A subset of immune cells directly target colon cancers, rather than the immune system, giving the cells the aggressive properties of cancer stem cells, a new study finds.
NIH/National Cancer Institute

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 8-May-2014
PLOS Genetics
Exact outline of melanoma could lead to new diagnostic tools, therapies
Researchers have identified a specific biochemical process that can cause normal and healthy skin cells to transform into cancerous melanoma cells, which should help predict melanoma vulnerability and could also lead to future therapies. They discovered in this situation that the immune system is getting thrown into reverse, helping to cause cancer instead of preventing it.
National Institutes of Health

Contact: Arup Indra
arup.indra@oregonstate.edu
541-737-5775
Oregon State University

Public Release: 8-May-2014
Radiotherapy & Oncology
Wake Forest Baptist finds success with novel lung cancer treatment
An old idea of retreating lung tumors with radiation is new again, especially with the technological advances seen in radiation oncology over the last decade.

Contact: Bonnie Davis
bdavis@wakehealth.edu
336-716-4977
Wake Forest Baptist Medical Center

Public Release: 8-May-2014
Chemistry & Biology
New technology using florescent proteins tracks cancer cells circulating in the blood
After cancer spreads, finding and destroying malignant cells that circulate in the body is usually critical to patient survival. Now, researchers reporting in the Cell Press journal Chemistry & Biology have developed a new method that allows investigators to label and track single tumor cells circulating in the blood. This advance could help investigators develop a better understanding of cancer spread and how to stop it.

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press

Public Release: 8-May-2014
PLOS ONE
Honolulu-based study reveals shorter men live longer
Short height and long life have a direct connection in Japanese men, according to new research based on the Kuakini Honolulu Heart Program and the Kuakini Honolulu-Asia Aging Study. Shorter men are more likely to have a protective form of the longevity gene, FOXO3, leading to smaller body size during early development and a longer lifespan. Shorter men are also more likely to have lower blood insulin levels and less cancer.

Contact: Tina Shelton
sheltont@hawaii.edu
808-692-0897
University of Hawaii at Manoa

Public Release: 8-May-2014
Journal of Clinical Investigation
JCI online ahead of print table of contents for May 8, 2014
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers published online, May 8, 2014, in the JCI: 'Leptin-dependent regulation of reproduction,' 'Female susceptibility to CNS autoimmunity linked to sphingosine-1 phosphate receptor,' 'Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction,' 'Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus,' 'Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm,' and more.

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 8-May-2014
Science Signaling
Chemotherapy timing is key to success
Nanoparticles that stagger delivery of two drugs knock out aggressive tumors.

Contact: Andrew Carleen
acarleen@mit.edu
617-253-1682
Massachusetts Institute of Technology

Public Release: 8-May-2014
Journal of Cell Science
Ovarian cancer cells are more aggressive on soft tissues
When ovarian cancer spreads from the ovaries it almost always does so to a layer of fatty tissue that lines the gut. A new study has found that ovarian cancer cells are more aggressive on these soft tissues due to the mechanical properties of this environment. The finding is contrary to what is seen with other malignant cancer cells that seem to prefer stiffer tissues.
National Science Foundation, Georgia Tech, Emory Center for Regenerative Medicine

Contact: Brett Israel
brett.israel@comm.gatech.edu
404-385-1933
Georgia Institute of Technology

Public Release: 8-May-2014
Cell Reports
How immune cells use steroids
Researchers at the European Bioinformatics Institute and the Wellcome Trust Sanger Institute have discovered that some immune cells turn themselves off by producing a steroid. The findings, published in Cell Reports, have implications for the study of cancers, autoimmune diseases and parasitic infections.
European Research Council

Contact: Sonia Furtado Neves
pressoffice@embl.de
49-622-138-78263
European Molecular Biology Laboratory

Public Release: 8-May-2014
Journal of Community Genetics
Few women at high-risk for hereditary breast and ovarian cancer receive genetic counseling
Mutations in the BRCA1 and BRCA2 genes account for nearly 25 percent of hereditary breast cancers and most hereditary ovarian cancers, yet a study by cancer prevention and control researchers at Virginia Commonwealth University Massey Cancer Center suggests an alarmingly small amount of women who qualify for BRCA genetic counseling actually receive the services. Additionally, they found that a significant proportion of women with a family history of breast and ovarian cancer underestimate their risk.
NIH/National Cancer Institute

Contact: John Wallace
wallacej@vcu.edu
804-628-1550
Virginia Commonwealth University

Public Release: 7-May-2014
Journal of Clinical Investigation
Pushing the boundaries of stem cells
Adults suffering from diseases such as leukemia, lymphoma, and other blood-related disorders may benefit from life-saving treatment commonly used in pediatric patients. Researchers at the Icahn School of Medicine at Mount Sinai have identified a new technique that causes cord blood stems cells to generate in greater numbers making them more useful in adult transplantation.
Empire State Stem Cell Board

Contact: Lucia Lee
NewsMedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine

Showing releases 1126-1150 out of 1240.

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