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Showing releases 1151-1175 out of 1333.

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Public Release: 18-Dec-2014
Cancer Cell
Scientists map out how childhood brain tumors relapse
Researchers have discovered the unique genetic paths that the childhood brain tumor medulloblastoma follows when the disease comes back
Cancer Research UK, Action Medical Research, Sparks, The Brain Tumour Charity, JGW Patterson Foundation, Christopher's Smile

Contact: Simon Shears
Cancer Research UK

Public Release: 18-Dec-2014
Machine learning reveals unexpected genetic roots of cancers, autism and other disorders
A Canadian research team led by professor Brendan Frey has developed the first method for 'ranking' genetic mutations based on how living cells 'read' DNA, revealing how likely any given alteration is to cause disease. They use a new 'machine learning' computational technique developed at the University of Toronto to discover unexpected genetic determinants of autism, hereditary cancers and spinal muscular atrophy, a leading genetic cause of infant mortality.
Canadian Institute for Advanced Research, Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, McLaughlin Centre, Autism Speaks, Genome Canada

Contact: RJ Taylor
University of Toronto Faculty of Applied Science & Engineering

Public Release: 18-Dec-2014
American Journal of Pathology
How does prostate cancer form?
The cause of prostate cancer may be linked to Parkinson's disease through a common enzyme.
National Institutes of Health, China Scholarship Foundation, Pennsylvania Department of Health

Contact: Edyta Zielinska
Thomas Jefferson University

Public Release: 18-Dec-2014
Cells identified that enhance tumor growth and suppress anti-cancer immune attack
A study led by St. Jude Children's Research Hospital scientists has identified the population of white blood cells that tumors use to enhance growth and suppress the disease-fighting immune system. The results, which appear in the Dec. 18 edition of the scientific journal Immunity, mark a turning point in cancer immunology and provide the foundation for developing more effective immunotherapies.
Hartwell Foundation, Alex's Lemonade Stand Foundation, NIH/National Cancer Institute, ALSAC

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

Public Release: 18-Dec-2014
BJU International
Laparoscopic surgery for bladder cancer leads to good long-term cancer control
Long-term survival rates following laparoscopic surgery for bladder cancer are comparable to those of open surgery, according to a study published in BJU International.

Contact: Evelyn Martinez

Public Release: 18-Dec-2014
Cell Metabolism
A change of diet to unmask cancer vulnerabilities and reduce cancer risk
Many recent studies showed that calorie restrictions reduce the incidence of cancer, whereas high-calorie diets cause obesity and diabetes, both of which increase the risk of developing cancers. However, tumor biology still hides complex mechanisms, as revealed by researchers from the Faculty of Medicine of the University of Geneva, Switzerland. In a study published in Cell Metabolism, scientists not only found the unexpected benefit that a change of diet had on certain types of lung cancer, they also deciphered the molecular mechanism underlying this dietary effect and showed how this cancer vulnerability could be exploited in targeted treatment strategies with limited side effects.

Contact: Roberto Coppari
Université de Genève

Public Release: 18-Dec-2014
Nature Communications
Researchers ferret out a flu clue
For the first time it has been shown that ferrets share a mutation that was previously thought to be unique to humans, among the mammals. This helps to explain why the molecular characteristics of ferrets so uniquely mimic human susceptibility, severity and transmission of influenza A virus strains. These findings could pave the way to a completely novel approach to tackling human diseases from influenza through to cancer.

Contact: Helen Wright
Griffith University

Public Release: 18-Dec-2014
Cell Reports
Stem cells born out of indecision
Scientists at the University of Copenhagen have gained new insight into embryonic stem cells and how blocking their ability to make choices explains why they stay as stem cells in culture. The results have just been published in the scientific journal Cell Reports.

Contact: Joshua Brickman
University of Copenhagen - The Faculty of Health and Medical Sciences

Public Release: 18-Dec-2014
Nature Medicine
Mutations prevent programmed cell death
Programmed cell death is a mechanism that causes defective and potentially harmful cells to destroy themselves. It serves a number of purposes in the body, including the prevention of malignant tumor growth. Now, researchers at Technische Universität München have discovered a previously unknown mechanism for regulating programmed cell death. They have also shown that patients with lymphoma often carry mutations in this signal pathway.

Contact: Vera Siegler
Technische Universitaet Muenchen

Public Release: 18-Dec-2014
Mutations need help from aging tissue to cause leukemia
University of Colorado Cancer Center study published today in the journal Aging shows that in addition to DNA damage, cancer depends on the slow degradation of tissue that surrounds cancer cells, something that naturally comes with aging.

Contact: Garth Sundem
University of Colorado Denver

Public Release: 17-Dec-2014
Journal of the American Chemical Society
New class of synthetic molecules mimics antibodies
A Yale University lab has crafted the first synthetic molecules that have both the targeting and response functions of antibodies. The new molecules -- synthetic antibody mimics -- attach themselves simultaneously to disease cells and disease-fighting cells. The result is a highly targeted immune response, similar to the action of natural human antibodies.

Contact: Jim Shelton
Yale University

Public Release: 17-Dec-2014
Cell Cycle
Orphan receptor proteins deliver 2 knock-out punches to glioblastoma cells
Two related proteins exert a lethal double whammy effect against glioblastoma cells when activated with a small molecule. Scientists say when activated, one protein, called the short form, stops glioblastoma cells from replicating their DNA, and the other, called the long form, prevents cell division if the DNA has already been replicated.
NIH/National Cancer Institute

Contact: Karen Teber
Georgetown University Medical Center

Public Release: 17-Dec-2014
'Master regulator' gene -- long tied to autism disorders -- stimulates other genes in early brain development
Chemical modifications to DNA's packaging -- known as epigenetic changes -- can activate or repress genes involved in autism spectrum disorders and early brain development, according to a new study to be published in the journal Nature on Dec. 18.

Contact: David March
NYU Langone Medical Center / New York University School of Medicine

Public Release: 17-Dec-2014
FASEB Journal
Study shows how breast cancer cells break free to spread in the body
More than 90 percent of cancer-related deaths are caused by the spread of cancer cells from their primary tumor site to other areas of the body. A new study has identified how one important gene helps cancer cells break free from the primary tumor.
National Science Foundation

Contact: Brett Israel
Georgia Institute of Technology

Public Release: 17-Dec-2014
Journal of American Chemical Society
A new strategy for developing drugs to fight cancer and other diseases
Promising treatments known as biologics are on the market and under development for many serious illnesses such as cancer, but some of them come with high risks, even lethal ones. Now scientists have produced a novel class of molecules that could be as effective but without the dangerous side effects. They report their work on these compounds, which they tested on prostate cancer cells, in ACS' Journal of the American Chemical Society.
National Institutes of Health, Bristol-Myers Squibb

Contact: Michael Bernstein
American Chemical Society

Public Release: 17-Dec-2014
Clinical Cancer Research
'Sugar-coated' microcapsule eliminates toxic punch of experimental anti-cancer drug
Johns Hopkins researchers have developed a sugar-based molecular microcapsule that eliminates the toxicity of an anticancer agent developed a decade ago at Johns Hopkins, called 3-bromopyruvate, or 3BrPA, in studies of mice with implants of human pancreatic cancer tissue. The encapsulated drug packed a potent anticancer punch, stopping the progression of tumors in the mice, but without the usual toxic effects.
NIH/National Cancer Institute, Rolf W. Gunther Foundation for Radiological Science, American Cancer Society, Virginia and D.K. Ludwig Fund for Cancer Research, Lustgarten Foundation

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 17-Dec-2014
Cancer Research
Researcher to cancer: 'Resistance will be futile'
Turning the tables, Katherine Borden at the University of Montreal's Institute for Research in Immunology and Cancer has evoked Star Trek's Borg in her fight against the disease.
National Institutes of Health, Leukemia & Lymphoma Society, Canada Research Chair in Molecular Biology of the Cell Nucleus, Cole Foundation, National Council for Scientific Research Lebanon, Pharmascience

Contact: William Raillant-Clark
University of Montreal

Public Release: 17-Dec-2014
Journal of Thoracic Oncology
A survey of the general population in France identifies knowledge gaps in the perception of lung cancer
A prospective nationwide survey on perceptions of lung cancer in the general population of France highlights a need for increased public education on the benefits of lung cancer screening, the good survival rates of early-stage disease and the improved outcomes with new therapeutic strategies, including targeted-therapies.

Contact: Murry W. Wynes, Ph.D.
International Association for the Study of Lung Cancer

Public Release: 17-Dec-2014
Journal of Thoracic Oncology
Targeted next-generation sequencing reveals a high number of genomic mutations in advanced malignant
Next generation sequencing in malignant pleural mesothelioma tumors shows a complex mutational setting with a high number of genetic alterations in genes involved in DNA repair, cell survival and cell proliferation pathways. Increased accumulation of mutations correlates with early progression of the tumor and decreased survival.

Contact: Murry W. Wynes, Ph.D.
International Association for the Study of Lung Cancer

Public Release: 17-Dec-2014
Science Translational Medicine
Lens-free microscope can detect cancer at the cellular level
UCLA researchers have developed a lens-free microscope that can be used to detect the presence of cancer or other cell-level abnormalities with the same accuracy as larger and more expensive optical microscopes.

Contact: Bill Kisliuk
University of California - Los Angeles

Public Release: 16-Dec-2014
Gastrointestinal Endoscopy
Mayo Clinic physicians say high-definition scopes accurately assess polyps
It may not be necessary for experienced gastroenterologists to send polyps they remove from a patient's colon to a pathologist for examination, according to a large study conducted by physician researchers at the Jacksonville campus of Mayo Clinic.
Olympus Corporation of America

Contact: Kevin Punsky
Mayo Clinic

Public Release: 16-Dec-2014
Cancer Cell
Single genetic abnormality accelerates, removes the brakes on Ewing sarcoma tumor growth
The genetic abnormality that drives the bone cancer Ewing sarcoma operates through two distinct processes -- both activating genes that stimulate tumor growth and suppressing those that should keep cancer from developing.
Burroughs Wellcome Fund, Howard Hughes Medical Institute, Hyundai Hope on Wheels, NIH/National Human Genome Research Institute

Contact: Katie Marquedant
Massachusetts General Hospital

Public Release: 16-Dec-2014
Proceedings of the National Academy of Sciences
Bacterial 'bunches' linked to some colorectal cancers
Researchers from Johns Hopkins have found that dense mats of interacting bacteria, called biofilms, were present in the majority of cancers and polyps, particularly those on the right side of the colon. The presence of these bacterial bunches, they say, may represent an increased risk for colon cancer and could form the basis of new diagnostic tests.
National Institutes of Health, Alexander and Margaret Stewart Trust, American Society of Colon and Rectal Surgeons, Merieux Institute

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 16-Dec-2014
Developmental Cell
Vessel research offers new direction to study how cancer spreads
Researchers have understood very little about how blood and lymphatic vessels form in the mammalian gut -- until now. A new Cornell University study reports for the first time how arteries form to supply the looping embryonic gut with blood, and how these arteries guide development of the gut's lymphatic system.
Cornell Center for Vertebrate Genomics, National Institutes of Health, March of Dimes.

Contact: Melissa Osgood
Cornell University

Public Release: 16-Dec-2014
Circulation: Cardiovascular Interventions
Real-time radiation monitor can reduce radiation exposure for medical workers
It's a sound that saves. A 'real-time' radiation monitor that alerts by beeping in response to radiation exposure during cardiac-catheterization procedures significantly reduces the amount of exposure that medical workers receive, University of Texas Southwestern Medical Center researchers found.
US Department of Veterans Affairs, Dallas Veterans Affairs Research Corporation, Gilead, Medicines Company

Contact: Cathy Frisinger
UT Southwestern Medical Center

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