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Public Release: 9-Jun-2014
Annals of Internal Medicine
News from Annals of Internal Medicine tip sheet -- June 10, 2014
The June 10 issue of Annals of Internal Medicine contains articles titled 'Increase screening rates to prevent cervical cancer, experts suggest' and 'Experts explain merits and shortcomings of Medicare data release.'

Contact: Megan Hanks
American College of Physicians

Public Release: 8-Jun-2014
Nature Genetics
Longer telomeres linked to risk of brain cancer
New genomic research led by UC San Francisco scientists reveals that two common gene variants that lead to longer telomeres, the caps on chromosome ends thought by many scientists to confer health by protecting cells from aging, also significantly increase the risk of developing the deadly brain cancers known as gliomas.
National Institutes of Health, National Brain Tumor Foundation, University of California, San Francisco

Contact: Peter Farley
University of California - San Francisco

Public Release: 8-Jun-2014
Nature Chemical Biology
New molecule enables quick drug monitoring
Scientists at EPFL have invented a molecule that can easily and quickly show how much drug is in a patient's system. The molecule, now the basis of a start-up company, is expected to enable point-of-care therapeutic drug monitoring.
École polytechnique fédérale de Lausanne, Swiss National Science Foundation, National Centre of Competence in Research Chemical Biology, Defense Threat Reduction

Contact: Nik Papageorgiou
Ecole Polytechnique Fédérale de Lausanne

Public Release: 8-Jun-2014
Health Affairs
Health Affairs asks: Where can we find savings in health care?
The June issue of Health Affairs features various approaches to cost savings in the US health care system, and several other articles that may be of interest to the global community.

Contact: Sue Ducat
Health Affairs

Public Release: 8-Jun-2014
Nature Materials
Targeting tumors using silver nanoparticles
Scientists at UC Santa Barbara have designed a nanoparticle that has a couple of unique -- and important -- properties. Spherical in shape and silver in composition, it is encased in a shell coated with a peptide that enables it to target tumor cells. What's more, the shell is etchable so those nanoparticles that don't hit their target can be broken down and eliminated. The research findings appear today in the journal Nature Materials.

Contact: Julie Cohen
University of California - Santa Barbara

Public Release: 6-Jun-2014
Journal of Molecular Diagnostics
Biomarkers accurately distinguish mesothelioma from non-cancerous tissue
Scientists have identified four biomarkers that may help resolve the difficult differential diagnosis between malignant pleural mesothelioma (MPM) and non-cancerous pleural tissue with reactive mesothelial proliferations. This is a frequent differential diagnostic problem in pleural biopsy samples taken from patients with clinical suspicion of MPM. The ability to make more accurate diagnoses earlier may facilitate improved patient outcomes. This new study appears in the Journal of Molecular Diagnostics.

Contact: Eileen Leahy
Elsevier Health Sciences

Public Release: 6-Jun-2014
Journal of Virology
Herpesviruses undercover
Pathogens entering our body only remain unnoticed for a short period. Within minutes our immune cells detect the invader and trigger an immune response. However, some viruses have developed strategies to avoid detection and elimination by our immune system. Researchers from the Helmholtz Centre for Infection Research in Braunschweig have now been able to show how the herpesviruses achieve this.

Contact: Rebecca Winkels
Helmholtz Centre for Infection Research

Public Release: 6-Jun-2014
Endocrine-Related Cancer
Prostate cancer biomarkers identified in seminal fluid
Improved diagnosis and management of one of the most common cancers in men -- prostate cancer -- could result from research at the University of Adelaide, which has discovered that seminal fluid contains biomarkers for the disease.
Prostate Cancer Foundation

Contact: Dr. Luke Selth
University of Adelaide

Public Release: 6-Jun-2014
Gastrointestinal Endoscopy
Endoscope with an oxygen sensor detects pancreatic cancer
An optical blood oxygen sensor attached to an endoscope is able to identify pancreatic cancer in patients via a simple lendoscopic procedure, according to researchers at Mayo Clinic in Florida.
National Institutes of Health, NIH/National Cancer Institute, Mayo Clinic Foundation for Medical Education & Research

Contact: Kevin Punsky
Mayo Clinic

Public Release: 6-Jun-2014
Scientists reveal details of calcium 'safety-valve' in cells
The New York Consortium on Membrane Protein Structure used X-rays at Brookhaven Lab's National Synchrotron Light Source to decipher the atomic level structure of a protein that regulates the level of calcium in cells, providing clues about a key signaling agent that can trigger programmed cell death and potentially leading to new anticancer drug targets.
National Institutes of Health, US Department of Energy

Contact: Karen McNulty Walsh
DOE/Brookhaven National Laboratory

Public Release: 6-Jun-2014
Clinical Gastroenterology and Hepatology
Probiotics prevent deadly complications of liver disease
Probiotics are effective in preventing hepatic encephalopathy in patients with cirrhosis of the liver, according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association.

Contact: Rachel Steigerwald
American Gastroenterological Association

Public Release: 5-Jun-2014
ASCO 50th Annual Meeting
Race could be a factor in head and neck cancer survival rates, MU researchers find
The national survival rates for African-Americans diagnosed with head and neck cancer have not improved in the last 40 years despite advances in the treatment and management of the disease, University of Missouri School of Medicine researchers have found. The researchers suggest that inherent genetic factors in African-Americans may make some tumors resistant to treatments. However, more research needs to be done on the subject of survival disparity in patients with head and neck cancer.

Contact: Derek Thompson
University of Missouri-Columbia

Public Release: 5-Jun-2014
Breast Cancer Research
Can mice mimic human breast cancer? MSU study says 'yes'
Eran Andrechek, a physiology professor in the College of Human Medicine at Michigan State University, has discovered that many of the various models used in breast cancer research can replicate several characteristics of the human disease, especially at the gene level.
National Institutes of Health, Susan G. Komen Foundation

Contact: Sarina Gleason
Michigan State University

Public Release: 5-Jun-2014
Molecular Cell
Discovered a new way to control genetic material altered in cancer
When we speak of genetic material, we are usually referring to the DNA that we inherit from our parents. This DNA is the factory where is built a similar molecule called RNA which produces our proteins, such as hemoglobin or insulin, allowing the lives of our cells. But there is a special group called non-coding RNA that has a more enigmatic function.

Contact: Arantxa Mena
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 5-Jun-2014
Cell Reports
Our own treacherous immune genes can cause cancer after viral infection
Mutations that cause cancer following HPV, human papillomavirus, infection are caused by a family of genes that normally protect against viral infections, finds new UCL research. This raises the possibility of developing drugs that block the activity of these genes to prevent HPV-associated cancers from developing and reduce the ability of existing cancers to evolve resistance to treatments.
Rosetrees Trust, Debbie Fund, Cancer Research UK

Contact: Harry Dayantis
University College London

Public Release: 5-Jun-2014
Research helps clarify how obesity leads to type 2 diabetes, cancer
In a study published online June 5 in the journal Cell, a researcher at The University of Texas at Dallas and colleagues at the University of California, San Diego found that a protein called HIF-1 alpha plays a key role in the development of insulin resistance and type 2 diabetes in obese mice. The findings may also shed light on the connection between obesity and cancer.
National Institutes of Health, American Diabetes Association

Contact: Amanda Siegfried
University of Texas at Dallas

Public Release: 5-Jun-2014
ASCO 50th Annual Meeting
Early palliative support services help those caring for patients with advanced cancer
Dartmouth researchers have found that those caring for patients with advanced cancer experienced reduced depression and felt less burdened by caregiving tasks when palliative support services were offered soon after the patient's diagnosis. They presented their findings at the American Society of Clinical Oncologist annual meeting in Chicago on June 3, 2014.

Contact: Robin Dutcher
The Geisel School of Medicine at Dartmouth

Public Release: 5-Jun-2014
JAMA Otolaryngology--Head & Neck Surgery
Study finds public awareness of head and neck cancers low
Public awareness of head and neck cancer is low, with few Americans knowing much about risk factors such as tobacco use and human papillomavirus.

Contact: Helen Dodson
The JAMA Network Journals

Public Release: 5-Jun-2014
Scientists find new targets that could increase effectiveness of breast cancer treatments
Scientists from the Florida campus of the Scripps Research Institute have found new targets for potential intervention in breast cancer. These new targets could eventually increase effectiveness and reduce the undesirable side effects associated with current treatments.
National Institutes of Health, NIH/National Cancer Institute

Contact: Eric Sauter
Scripps Research Institute

Public Release: 5-Jun-2014
MAD: Scientists shed light on braking mechanisms in cellular signaling
A team of researchers studying a flowering plant has zeroed in on the way cells manage external signals about prevailing conditions, a capability that is essential for cells to survive in a fluctuating environment.

Contact: Zhiyong Wang
Carnegie Institution

Public Release: 5-Jun-2014
Cancer Discovery
Seemingly invincible cancers stem cells reveal a weakness
Metastatic cancer cells, which can migrate from primary tumors to seed new malignancies, have thus far been resistant to the current arsenal of anticancer drugs. Now, however, researchers at Whitehead Institute have identified a critical weakness that actually exploits one of these cells' apparent strengths -- their ability to move and invade tissues. Their research could inform novel approaches to screening tumors for personalized therapy or to drugs that specifically target these cells.
Richard and Susan Smith Family Foundation, Breast Cancer Alliance

Contact: Nicole Giese Rura
Whitehead Institute for Biomedical Research

Public Release: 5-Jun-2014
Analytical Chemistry
Research could lead to new cancer assay, aid both dogs and humans
Veterinary researchers have identified a unique group of proteins that indicate the presence of transitional cell carcinoma -- the most common cause of bladder cancer -- and may lead to a new assay which could better diagnose this disease in both dogs and humans.
NIH/National Insitutes of Environmental Health Sciences

Contact: Shay Bracha
Oregon State University

Public Release: 5-Jun-2014
Brain circuit problem likely sets stage for the 'voices' that are symptom of schizophrenia
St. Jude Children's Research Hospital scientists have identified problems in a connection between brain structures that may predispose individuals to hearing the 'voices' that are a common symptom of schizophrenia. The work appears in the June 6 issue of the journal Science.
National Institutes of Health, American-Lebanese-Syrian Associated Charities

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

Public Release: 5-Jun-2014
European Society for Medical Oncology World Conference on Gastrointestinal Cancer
New therapy for pancreatic cancer patients shows promising results
A clinical trial conducted by researchers at the Virginia G. Piper Cancer Center Clinical Trials, a partnership between Scottsdale Healthcare and the Translational Genomics Research Institute, showed that a new drug called MM-398, given in combination with 5-flourouracil and leucovorin, produced a significant overall survival rate in patients with advanced, previously-treated pancreatic cancer.
Merrimack Pharmaceuticals

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Public Release: 5-Jun-2014
Cell Stem Cell
Stem cells hold keys to body's plan
Case Western Reserve researchers have discovered landmarks within pluripotent stem cells that guide how they develop to serve different purposes within the body. This breakthrough offers promise that scientists eventually will be able to direct stem cells in ways that prevent disease or repair damage from injury or illness. The study and its results appear in the June 5 edition of the journal Cell Stem Cell.
National Institutes of Health, New York Stem Cell Foundation, Mount Sinai Health Care Foundation, Case Comprehensive Cancer Center, Case Western Reserve University

Contact: Jeannette Spalding
Case Western Reserve University

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