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Showing releases 1151-1175 out of 1275.

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Public Release: 19-Feb-2014
Science Translational Medicine
Cell therapy shows remarkable ability to eradicate cancer in clinical study
The largest clinical study ever conducted to date of patients with advanced leukemia found that 88 percent achieved complete remissions after being treated with genetically modified versions of their own immune cells.
NIH/National Cancer Institute, Terry Fox Foundation, and others

Contact: Andrea Baird
bairda@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center

Public Release: 19-Feb-2014
Leukemia
Infants with leukemia inherit susceptibility
Babies who develop leukemia during the first year of life appear to inherit an unfortunate combination of genetic variations that may make the infants highly susceptible to the disease, according to a new study at Washington University School of Medicine in St. Louis and the University of Minnesota.
Children's Discovery Institute, National Institutes of Health, NIH/National Cancer Institute, Alex's Lemonade Stand 'A' Award, Hyundai Hope Award

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine

Public Release: 19-Feb-2014
New England Journal of Medicine
Adding bevacizumab to initital glioblastoma treatment doesn't improve overall survival
Results of a randomized phase III clinical trial conducted by the Radiation Therapy Oncology Group determined that adding bevacizumab to initial treatment for glioblastoma did not improve patient overall survival or progression-free survival. Results appear in the Feb. 20, 2014, issue of the New England Journal of Medicine.

Contact: Nancy Fredericks
nfredericks@acr.org
610-715-7707
American College of Radiology

Public Release: 19-Feb-2014
Biophysical Society 58th Annual Meeting
Clutter cutter
In a messy house, people use computers to manage paper and photo clutter; companies use computer systems to track their inventory. Now a team of researchers at Vanderbilt University in Nashville, Tenn., is taking a similar approach to cell-molecular inventory control for cancer. They have created computer models, using their programming framework, which enable them to explore the complex biochemical processes that drive cancer growth.

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
American Institute of Physics

Public Release: 19-Feb-2014
Journal of the National Cancer Institute
HPV vaccination is associated with reduced risk of cervical lesions in Denmark
A reduced risk of cervical lesions among Danish girls and women at the population level is associated with use of a quadrivalent HPV vaccine after only six years, according to a new study published Feb. 19 in the Journal of the National Cancer Institute.

Contact: Zachary Rathner
Zachary.Rathner@oup.com
919-677-2697
Oxford University Press

Public Release: 19-Feb-2014
Scientific Reports
Targeted treatment for ovarian cancer discovered
Researchers at Women & Infants Hospital of Rhode Island have developed a biologic drug that would prevent the production of a protein known to allow ovarian cancer cells to grow aggressively while being resistant to chemotherapy. This would improve treatment and survival rates for some women.

Contact: Susan McDonald
slmcdonald@wihri.org
401-681-2816
Women & Infants Hospital

Public Release: 18-Feb-2014
Nature Communications
New drug candidate starves dormant cancer cells
In a study published in Nature Communications, researchers at Karolinska Institutet and Uppsala University in Sweden present a new drug candidate, which selectively kills dormant cells within a cancer tumor through starvation.
Swedish Cancer Society, Swedish Research Council

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet

Public Release: 18-Feb-2014
British Medical Journal
New anti-smoking policies in China could save nearly 13 million lives in next 40 years
Almost 13 million lives could be saved by 2050 in China if the country implements comprehensive tobacco control recommendations set forth by the World Health Organization.
National Institutes of Health, Fogarty International Center, European Commission, Bloomberg Philanthropy Program

Contact: Karen Teber
km463@georgetown.edu
Georgetown University Medical Center

Public Release: 18-Feb-2014
PLOS ONE
Dartmouth-UConn study shows coastal water, not sediment, predicts mercury contamination
A Dartmouth-University of Connecticut study of the northeast United States shows that methylmercury concentrations in estuary waters -- not in sediment as commonly thought -- are the best way to predict mercury contamination in the marine food chain.
NIH/National Institutes of Environmental Health Sciences

Contact: John Cramer
John.Cramer@Dartmouth.edu
603-646-9130
Dartmouth College

Public Release: 18-Feb-2014
eLife
Mitosis mystery solved as role of key protein is confirmed
Researchers from Warwick Medical School have discovered the key role of a protein in shutting down endocytosis during mitosis, answering a question that has evaded scientists for half a century.
Biotechnology and Biological Sciences Research Council

Contact: Luke Harrison
luke.harrison@warwick.ac.uk
University of Warwick

Public Release: 18-Feb-2014
PLOS Medicine
The number of tumor cells spread to sentinel lymph nodes affects melanoma prognosis
Cancer cell spread to the sentinel node -- the lymph node to which cancer cells are most likely to spread from a primary tumor -- is a risk factor for melanoma death.
University of Tübingen

Contact: Fiona Godwin
medicinepress@plos.org
PLOS

Public Release: 18-Feb-2014
Journal of Clinical Oncology
More women receiving breast reconstruction after mastectomy, study finds
A new study finds that the majority of women who undergo mastectomy for breast cancer go on to get breast reconstruction, a practice that has increased dramatically over time.
American Cancer Society, Cancer Prevention and Research Institute of Texas

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 18-Feb-2014
Nucleic Acids Research
Wistar scientists develop gene test to accurately classify brain tumors
Scientists at the Wistar Institute have developed a mathematical method for classifying forms of glioblastoma, an aggressive and deadly type of brain cancer, through variations in the way these tumor cells 'read' genes. Their system was capable of predicting the subclasses of glioblastoma tumors with 92 percent accuracy. With further testing, this system could enable physicians to accurately predict which forms of therapy would benefit their patients the most.
National Institutes of Health

Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute

Public Release: 18-Feb-2014
Proceedings of the National Academy of Sciences
New treatment proposed to prevent intestinal inflammation in cancer patients
Experimental work pointing to a therapy for alleviating mucositis -- a common, severe side effect of chemotherapy and irradiation of cancer patients or patients prepared for bone marrow transplantation -- has been achieved by an international team of researchers from the US and Israel headed by scientists at the Hebrew University of Jerusalem.

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem

Public Release: 18-Feb-2014
PLOS ONE
COXEN model picks the best drug for ovarian cancer
A University of Colorado Cancer Center and University of Virginia study used a sophisticated model of ovarian cancer genetics to match the right tumor with the right drug. Patients who were matched in this way lived an average 21 months longer than patients who were not matched.

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

Public Release: 18-Feb-2014
Nature Biotechnology
Research team establishes benchmark set of human genotypes for sequencing
Scientistis from Harvard University and the Virginia Bioinformatics Institute of Virginia Tech have presented new methods to integrate data from different sequencing platforms, thus producing a reliable set of genotypes to benchmark human genome sequencing.

Contact: Tiffany Trent
ttrent@vt.edu
540-231-6822
Virginia Tech

Public Release: 18-Feb-2014
The Lancet
Cancer study shows earlier palliative care improves quality of life, patient satisfaction
Results of the first clinical study to assess the impact of providing early outpatient palliative care versus standard oncology care in a wide range of advanced cancers show that earlier care improved quality of life and patient satisfaction.

Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network

Public Release: 18-Feb-2014
Evolutionary Applications
Infected Tasmanian devils reveal how cancer cells evolve in response to humans
New research in Evolutionary Applications explains how efforts to tackle Tasmanian devil tumors offers a unique opportunity to understand how human selection alters the evolution of cancerous cells.

Contact: Ben Norman
Sciencenewsroom@wiley.com
44-012-437-70375
Wiley

Public Release: 17-Feb-2014
Oncogene
New finding points to potential options for attacking stem cells in triple-negative breast cancer
New research finds that a protein that fuels an inflammatory pathway does not turn off in breast cancer, resulting in an increase in cancer stem cells. This provides a potential target for treating triple negative breast cancer, the most aggressive form of the disease.
NIH/National Cancer Institute, Breast Cancer Research Foundation, Susan G. Komen for the Cure

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 17-Feb-2014
EMBO reports
Small non-coding RNAs could be warning signs of cancer
Small non-coding RNAs can be used to predict if individuals have breast cancer conclude researchers who contribute to The Cancer Genome Atlas project.

Contact: Barry Whyte
barry.whyte@embo.org
European Molecular Biology Organization

Public Release: 17-Feb-2014
PLOS ONE
Natural compound attacks HER2 positive breast cancer cells
A common compound known to fight lymphoma and skin conditions actually has a second method of action that makes it particularly deadly against certain aggressive breast tumors, researchers at Duke Medicine report.

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

Public Release: 17-Feb-2014
Molecular Cancer Therapeutics
Experimental drug could enhance multiple myeloma and myeloid leukemia therapies
A pre-clinical study led by Virginia Commonwealth University Massey Cancer Center and Department of Internal Medicine researchers suggests that an experimental drug known as dinaciclib could improve the effectiveness of certain multiple myeloma and myeloid leukemia therapies. The study, recently published in the journal Molecular Cancer Therapeutics, showed that dinaciclib disrupted a cell survival mechanism known as the unfolded protein response (UPR). Without the UPR, multiple myeloma and myeloid leukemia cells were unable to combat damage caused by some anti-cancer agents.
National Institutes of Health

Contact: John Wallace
wallacej@vcu.edu
804-628-1550
Virginia Commonwealth University

Public Release: 17-Feb-2014
Proceedings of the National Academy of Sciences
Kidney cancer reveals its weak link
A team of researchers at Chalmers University of Technology has found that kidney cancer cells have a quite different metabolism than other types of malignancies. The findings pave the way for new methods of diagnosing kidney cancer at an early stage, a feat that had eluded researchers earlier, and thereby fresh approaches to treatment.
Knut and Alice Wallenberg Foundation, Chalmers Foundation

Contact: Christian Borg
christian.borg@chalmers.se
46-317-723-395
Chalmers University of Technology

Public Release: 17-Feb-2014
Gynaecolgical Oncology Forum
HIV drug used to reverse effects of virus that causes cervical cancer
Drs. Ian and Lynne Hampson, from the University's Institute of Cancer Sciences and Dr. Innocent Orora Maranga, consultant in obstetrics and gynacology at KNH in Nairobi examined Kenyan women diagnosed with HPV positive early stage cervical cancer who were treated with the antiviral HIV drug lopinavir in Kenya.
UK Philanthropist Mr Ken Chorlton, Caring Cancer Trust, United in Cancer Charitable Trust

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester

Public Release: 17-Feb-2014
Journal of Clinical Endocrinology & Metabolism
NUS researchers make new discovery of protein as a promising target for treatment of ATC
Anaplastic thyroid carcinoma (ATC) is an aggressive type of cancer with a poor prognosis for which there is currently no effective treatment. Researchers from the National University of Singapore have discovered for the first time that an epithelial basement membrane protein, called laminin-5 gamma-2, has the potential to be an ideal target for the treatment of ATC.

Contact: Kimberley Wang
kimberley.wang@nus.edu.sg
National University of Singapore

Showing releases 1151-1175 out of 1275.

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