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Public Release: 5-Aug-2014
Mammography benefits women over 75
Mammography-detected breast cancer is associated with a shift to earlier stage diagnosis in older women, subsequently reducing the rate of more advanced, difficult-to-treat cases, according to a new study. Researchers said the findings lend support to regular mammography screening in women ages 75 and older.
Kaplan Cancer Research Fund

Contact: Linda Brooks
Radiological Society of North America

Public Release: 4-Aug-2014
Cancer Research
Weakness of leukemic stem cells discovered
Only one out of every two adult patients survive acute myeloid leukemia. But maybe there is some hope to have a therapy in the future: A team of Frankfurt-based researchers found out that leukemic stem cells have a weakness.

Contact: Anke Sauter
Goethe University Frankfurt

Public Release: 4-Aug-2014
Journal of Thoracic Oncology
Lung cancer diagnosis tool shown to be safe and effective for older patients
Researchers at University Hospital of South Manchester NHS Foundation Trust and The University of Manchester -- part of the Manchester Cancer Research Centre -- have looked at a newer technique: endobronchial ultrasound-guided transbronchial needle aspiration.

Contact: Alison Barbuti
University of Manchester

Public Release: 4-Aug-2014
Annals of Internal Medicine
Screening and drug therapy predicted to make hepatitis C a rare disease
Newly implemented screening guidelines and highly effective drug therapies could make hepatitis C a rare disease in the United States by 2036, according to the results of a predictive model developed at the University of Pittsburgh Graduate School of Public Health. The results of the analysis, funded by the National Institutes of Health and performed with the University of Texas MD Anderson Cancer Center, will be published in the Annals of Internal Medicine.
National Institutes of Health

Contact: Allison Hydzik
University of Pittsburgh Schools of the Health Sciences

Public Release: 4-Aug-2014
Journal of Men's Health
New recommendations for post-treatment care of prostate cancer survivors
Updated guidelines for prostate cancer survivorship care have been published in Journal of Men's Health.

Contact: Kathryn Ryan
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 4-Aug-2014
Cancer Prevention Research
Eating resistant starch may help reduce red meat-related colorectal cancer risk
Consumption of a type of starch that acts like fiber may help reduce colorectal cancer risk associated with a high red meat diet, according to a study published in Cancer Prevention Research, a journal of the American Association for Cancer Research.
National Health and Medical Research Council of Australia, Commonwealth Scientific and Industrial Research Organization, Flinders Medical Center Foundation

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 4-Aug-2014
Nature Cell Biology
Protein ZEB1 promotes breast tumor resistance to radiation therapy
One protein with the even more out-there name of zinc finger E-box binding homeobox 1, is now thought to keep breast cancer cells from being successfully treated with radiation therapy, according to a study at The University of Texas MD Anderson Cancer Center in Houston.
National Institutes of Health, Cancer Prevention Research Institute of Texas

Contact: Ron Gilmore
University of Texas M. D. Anderson Cancer Center

Public Release: 4-Aug-2014
Triple therapy revs up immune system against common brain tumor
A triple therapy for glioblastoma, including two types of immunotherapy and targeted radiation, has significantly prolonged the survival of mice with these brain cancers, according to a new report by scientists at the Johns Hopkins Kimmel Cancer Center.
WW Smith Charitable Foundation

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 4-Aug-2014
International Journal of Radiation Oncology • Biology • Physics
Single-fraction RT as effective as multiple-fraction RT for palliation of bone metastases
Standardizing prescribing practices for single-fraction radiation therapy for palliation of bone metastases could lead to cost savings and improvement in patients' quality of life, according to a study published in the Aug. 1, 2014, edition of the International Journal of Radiation Oncology ● Biology ● Physics, the official scientific journal of the American Society for Radiation Oncology.

Contact: Michelle Kirkwood
American Society for Radiation Oncology

Public Release: 4-Aug-2014
Version 2.0 of Prostate Cancer Risk Calculator now online, complete with emojis
A calculator to help men and their doctors assess their risk of prostate cancer has had a major upgrade, described online Monday in the Journal of the American Medical Association. 'The current version gives a more nuanced result that helps understand a man's risk of prostate cancer,' said Ian M. Thompson Jr., M.D., director of the Cancer Therapy & Research Center at the UT Health Science Center, who helped develop the risk calculator.
NIH/National Cancer Institute

Contact: Elizabeth Allen
University of Texas Health Science Center at San Antonio

Public Release: 4-Aug-2014
BMC Cell Biology
Cell plasticity may provide clues to origin of aggressive type of breast cancer
Healthy breast cells may be able to reinvent themselves -- some have the flexibility to change after they are mature -- which leads researchers to postulate that similarities exist between this occurrence and the origins of a particularly aggressive type of breast cancer.
Susan G. Komen for the Cure, The Breast Cancer Research Foundation, Oracle Giving, Indiana University Melvin and Bren Simon Cancer Center, Indiana University Department of Surgery

Contact: Mary Hardin
Indiana University

Public Release: 4-Aug-2014
Journal of Clinical Oncology
Patient navigation may aid in breast cancer treatment in high-risk populations
Patient navigation, or the linking of a newly diagnosed cancer patient with a professional trained in assisting patients though the complex journey of cancer diagnosis and treatment, may lead to better breast cancer care in high risk and minority women.

Contact: Gina DiGravio
Boston University Medical Center

Public Release: 3-Aug-2014
Knowing what to keep and what to trash: How an enzyme distinguishes cellular messages
In the cell, proteins read through messages to distinguish what needs to be saved and what needs to be discarded. Messages that are marked for disposal can drastically alter the fate of a cell. Stem cells use this mechanism to maintain their identity. How does a protein detect the difference between two similar messages? A team of CSHL scientists have found that the protein Dis3l2 uses numerous recognition sites to capture messages for decay.
Watson School of Biological Sciences, Louis Morin Charitable Trust, Robertson Research Fund of Cold Spring Harbor Laboratory

Contact: Jaclyn Jansen
Cold Spring Harbor Laboratory

Public Release: 3-Aug-2014
Nature Genetics
Tumor suppressor mutations alone don't explain deadly cancer
Although mutations in a gene dubbed 'the guardian of the genome' are widely recognized as being associated with more aggressive forms of cancer, researchers at the University of California, San Diego School of Medicine have found evidence suggesting that the deleterious health effects of the mutated gene may in large part be due to other genetic abnormalities, at least in squamous cell head and neck cancers.
National Institutes of Health, Burroughs Welcome Fund, The American Cancer Society

Contact: Scott LaFee
University of California - San Diego

Public Release: 3-Aug-2014
New trick for 'old' drug brings hope for pancreatic cancer patients
Scientists have found a new use for an old drug by showing that it shrinks a particular type of pancreatic cancer tumor and stops it spreading.
Cancer Research UK

Contact: Flora Malein
Cancer Research UK

Public Release: 3-Aug-2014
Nature Methods
UMD researchers develop tool to better visualize, analyze human genomic data
Scientists at the University of Maryland have developed a new, web-based tool that enables researchers to quickly and easily visualize and compare large amounts of genomic information resulting from high-throughput sequencing experiments. The free tool, called Epiviz, offers a major advantage over browsers currently available: Epiviz seamlessly integrates with the open-source Bioconductor analysis software widely used by genomic scientists, through its Epivizr Bioconductor package.
National Institutes of Health

Contact: Abby Robinson
University of Maryland

Public Release: 3-Aug-2014
Nature Chemistry
Self-assembling anti-cancer molecules created in minutes
Researchers have developed a simple and versatile method for making artificial anti-cancer molecules that mimic the properties of one of the body's natural defense systems. The chemists, led by professor Peter Scott at the University of Warwick, UK, have been able to produce molecules that have a similar structure to peptides which are naturally produced in the body to fight cancer and infection.
Engineering and Physical Sciences Research Council, University of Warwick

Contact: Tom Frew
University of Warwick

Public Release: 3-Aug-2014
Nature Genetics
Study finds new genetic risk markers in pancreatic cancer
A large DNA analysis of people with and without pancreatic cancer has identified several new genetic markers that signal increased risk of developing the highly lethal disease, report scientists from Dana-Farber Cancer Institute.
NIH/National Cancer Institute, Lustgarten Foundation

Contact: Anne Doerr
Dana-Farber Cancer Institute

Public Release: 1-Aug-2014
Cancer Research
Recent use of some birth control pills may increase breast cancer risk
Women who recently used birth control pills containing high-dose estrogen and a few other formulations had an increased risk for breast cancer, whereas women using some other formulations did not, according to data published in Cancer Research, a journal of the American Association for Cancer Research.
NIH/National Cancer Institute

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 1-Aug-2014
Journal of Clinical Investigation
Pepper and halt: Spicy chemical may inhibit gut tumors
Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin -- the active ingredient in chili peppers -- produces chronic activation of a receptor on cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal tumors.
Crohn's and Colitis Foundation of America, Prins Bernhard Cultural Foundation, Scholten-Cordes Foundation, Dr. Hendrick Muller Vaderlandsch Foundation, Japan Society for the Promotion of Science, the European Molecular Biology Organization

Contact: Michelle Brubaker
University of California - San Diego

Public Release: 1-Aug-2014
Journal of Clinical Investigation
Study reveals one reason brain tumors are more common in men
New research at Washington University School of Medicine in St. Louis helps explain why brain tumors occur more often in males and frequently are more harmful.

Contact: Michael C. Purdy
Washington University School of Medicine

Public Release: 1-Aug-2014
European Urology
Taking the guesswork out of cancer therapy
Researchers and doctors at A*STAR's Institute of Bioengineering and Nanotechnology, Singapore General Hospital and National Cancer Centre Singapore have co-developed the first molecular test kit that can predict treatment and survival outcomes in kidney cancer patients. This breakthrough was recently reported in European Urology, the world's top urology journal.
Agency for Science, Technology and Research

Contact: Hiroshi Limmell
Biomedical Sciences Institutes (BMSI)

Public Release: 1-Aug-2014
Health Psychology
Expressive writing may help breast cancer survivors
Writing down fears, emotions and the benefits of a cancer diagnosis may improve health outcomes for Asian-American breast cancer survivors, according to a study conducted by a researcher at the University of Houston.
NIH/National Cancer Institute

Contact: Melissa Carroll
University of Houston

Public Release: 31-Jul-2014
Genes and Development
Molecular gate that could keep cancer cells locked up
Researchers from MRC Clinical Sciences Centre and the Brookhaven National Laboratory, N.Y., have revealed the location of a molecular gate on a ring-shaped enzyme that opens up to embrace DNA during the process of cell division. Once the DNA is encircled by the enzyme it begins to unwind its double helix to start a copying process which is integral to cell division.
Medical Research Council, German Research Foundation

Contact: Christian Speck
MRC Clinical Sciences Centre

Public Release: 31-Jul-2014
Human Vaccines & Immunotherapeutics
Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine
A long-term follow-up study shows the sustained efficacy, immunogenicity and safety of GlaxoSmithKline's human papillomavirus vaccine Cervarix. Women vaccinated with the vaccine were followed for more than nine years, and vaccine efficacy against incident infection was 100 percent. This is the longest follow-up report for a licensed human papillomavirus vaccine.

Contact: Andrew Thompson
Landes Bioscience

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