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Public Release: 5-Jun-2014
Cell Stem Cell
Fasting may help protect against immune-related effects of chemotherapy and aging
Chemotherapy can cause many side effects, including the depletion of immune cells. Even in the absence of chemotherapy, normal aging takes a heavy toll on the immune system. Now researchers have found that a simple dietary intervention -- periodic fasting -- may combat both chemotherapy-induced and aging-related changes in immune cell function by replenishing stem cells in the blood. The findings suggest that fasting may provide benefits for cancer patients, the elderly, and people with immune defects.

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press

Public Release: 5-Jun-2014
JAMA Otolaryngology--Head & Neck Surgery
Study finds public awareness of head and neck cancers low
Public awareness of head and neck cancer is low, with few Americans knowing much about risk factors such as tobacco use and human papillomavirus.

Contact: Helen Dodson
helen.dodson@yale.edu
203-436-3984
The JAMA Network Journals

Public Release: 5-Jun-2014
Cell Stem Cell
Fasting triggers stem cell regeneration of damaged, old immune system
In the first evidence of a natural intervention triggering stem cell-based regeneration of an organ or system, a study in the June 5 issue of the Cell Press journal Cell Stem Cell shows that cycles of prolonged fasting not only protect against immune system damage -- a major side effect of chemotherapy -- but also induce immune system regeneration, shifting stem cells from a dormant state to a state of self-renewal.
NIH/National Institute on Aging

Contact: Suzanne Wu
suzanne.wu@usc.edu
213-740-0252
University of Southern California

Public Release: 5-Jun-2014
Cell
Scientists generate long-sought molecular map of critical genetic machinery
A team led by researchers at The Scripps Research Institute has used advanced electron microscopy techniques to determine the first accurate structural map of Mediator, one of the largest and most complex 'molecular machines' in cells. The mapping of its structure -- which includes more than two dozen unique protein subunits--represents a significant advance in basic cell biology and should shed light on medical conditions involving Mediator's dysfunction, from cancer to inherited developmental disorders.
National Institutes of Health, Helen Nelson Medical Research Fund

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute

Public Release: 5-Jun-2014
Cell Reports
Our own treacherous immune genes can cause cancer after viral infection
Mutations that cause cancer following HPV, human papillomavirus, infection are caused by a family of genes that normally protect against viral infections, finds new UCL research. This raises the possibility of developing drugs that block the activity of these genes to prevent HPV-associated cancers from developing and reduce the ability of existing cancers to evolve resistance to treatments.
Rosetrees Trust, Debbie Fund, Cancer Research UK

Contact: Harry Dayantis
h.dayantis@ucl.ac.uk
44-020-310-83844
University College London

Public Release: 5-Jun-2014
Cell
Research helps clarify how obesity leads to type 2 diabetes, cancer
In a study published online June 5 in the journal Cell, a researcher at The University of Texas at Dallas and colleagues at the University of California, San Diego found that a protein called HIF-1 alpha plays a key role in the development of insulin resistance and type 2 diabetes in obese mice. The findings may also shed light on the connection between obesity and cancer.
National Institutes of Health, American Diabetes Association

Contact: Amanda Siegfried
amanda.siegfried@utdallas.edu
972-883-4335
University of Texas at Dallas

Public Release: 4-Jun-2014
Cancer Discovery
Four new genes confirmed to increase familial breast cancer risk
Four new genes have been added to the growing list of those known to cause increased breast cancer risk when mutated through the efforts of researchers at Huntsman Cancer Institute at the University of Utah, who lead an international consortium working to find more gene mutations that cause inherited breast cancer susceptibilities.
National Institutes of Health, Breast Cancer Family Registry, Huntsman Cancer Foundation

Contact: Linda Aagard
linda.aagard@hci.utah.edu
801-587-7639
University of Utah Health Sciences

Public Release: 4-Jun-2014
PLOS ONE
Mayo Clinic moves small-molecule drugs through blood-brain barrier
Researchers at Mayo Clinic have demonstrated in a mouse model that their recently developed synthetic peptide carrier is a potential delivery vehicle for brain cancer chemotherapy drugs and other neurological medications.

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic

Public Release: 4-Jun-2014
Medical Physics
New diagnostic imaging techniques deemed safe in simulations
Gamma and neutron imaging offer possible improvements over existing techniques such as X-ray or CT, but their safety is not yet fully understood. Using computer simulations, imaging the liver and breast with gamma or neutron radiation was found to be safe, delivering levels of radiation on par with conventional medical imaging, according to researchers at Duke Medicine.
National Institutes of Health

Contact: Rachel Harrison
rachel.harrison@duke.edu
919-419-5069
Duke University Medical Center

Public Release: 4-Jun-2014
Obestity Surgey
Weight loss surgery also safeguards obese people against cancer
Weight loss surgery might have more value than simply helping morbidly obese people to shed unhealthy extra pounds. It reduces their risk of cancer to rates almost similar to those of people of normal weight. This is the conclusion of the first comprehensive review article taking into account relevant studies about obesity, cancer rates and a weight loss procedure called bariatric surgery. Published in Springer's journal Obesity Surgery, the review was led by Daniela Casagrande.

Contact: Joan Robinson
joan.robinson@springer.com
49-622-148-78130
Springer

Public Release: 4-Jun-2014
Journal of Oncology Navigation & Survivorship
GW Cancer Institute conducts survey on moving toward quality patient-centered care
The George Washington University Cancer Institute published research in the Journal of Oncology Navigation and Survivorship on patient navigation and survivorship programs and the challenges many of these programs face.

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University

Public Release: 3-Jun-2014
Nature Medicine
'Liquid biopsy' offers new way to track lung cancer
Research carried out at Cancer Research UK's Manchester Institute, based at The University of Manchester -- part of the Manchester Cancer Research Centre -- has looked at the potential of using circulating tumor cells -- cells that have broken off from the tumor and are circulating in the blood -- to investigate a patient's disease in a minimally invasive manner.
Cancer Research UK

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester

Public Release: 3-Jun-2014
Science Signaling
New insight into drug resistance in metastatic melanoma
Now researchers from the Cancer Research UK Manchester Institute at The University of Manchester -- part of the Manchester Cancer Research Centre -- have explored what happens in melanoma cells following inhibition of BRAF.
Cancer Research UK

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester

Public Release: 3-Jun-2014
Nature Communications
Tumor chromosomal translocations reproduced for the first time in human cells
Scientists from the Spanish National Cancer Research Centre and the Spanish National Cardiovascular Research Centre have been able to reproduce, for the first time in human cells, chromosomal translocations associated with two types of cancer: acute myeloid leukemia and Ewing's sarcoma. The discovery, published today in the journal Nature Communications, opens the door to the development of new therapeutic targets to fight these types of cancer.

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 3-Jun-2014
Hepatology
Liver cancer vaccine effective in mice
Tweaking a protein expressed by most liver cancer cells has enabled scientists to make a vaccine that is exceedingly effective at preventing the disease in mice.
NIH/National Cancer Institute

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University

Public Release: 3-Jun-2014
Cancer
Screening has prevented half a million colorectal cancers
An estimated half a million cancers were prevented by colorectal cancer screening in the United States from 1976 to 2009, report researchers from the Cancer Outcomes, Public Policy, and Effectiveness Research Center at Yale Cancer Center. Their study appears in the journal Cancer. During this more than 30-year time span, as increasing numbers of men and women underwent cancer screening tests -- including fecal occult blood testing, sigmoidoscopies, and colonoscopies -- colorectal cancer rates declined significantly, the researchers found.
Medtronic, Johnson & Johnson, Natoinal Institutes of Health

Contact: Helen Dodson
helen.dodson@yale.edu
203-436-3984
Yale University

Public Release: 3-Jun-2014
Nucleic Acids Research
Deeper than ancestry.com, 'EvoCor' identifies gene relationships
A team led by Gregorio Valdez of the Virginia Tech Carilion Research Institute has designed a search engine that identifies genes that are functionally linked. The discovery may lead to ways to treat diseases that have a genetic component, such as cancer or Alzheimer's.

Contact: Paula Byron
pbyron@vt.edu
540-526-2027
Virginia Tech

Public Release: 3-Jun-2014
Technology
New device isolates most aggressive cancer cells
Not all cancer cells are created equal -- some stay put in the primary tumor, while others move and invade elsewhere. A major goal for cancer research is predicting which cells will metastasize, and why. A Cornell cancer research team is taking a new approach to screening for these dangerous cells, using a microfluidic device they invented that isolates only the most aggressive, metastatic cells.
NIH/National Cancer Institute

Contact: Melissa Osgood
mmo59@cornell.edu
607-255-2059
Cornell University

Public Release: 3-Jun-2014
CLEO: 2014
Lasers and night-vision technology help improve imaging of hidden lymphatic system
Detecting lymphedema early, before swelling occurs, would lead to better outcomes for patients, but the major barrier preventing early diagnosis is the lack of high-resolution imaging techniques that can resolve these tiny vessels. Recently, a team of researchers at UTHealth Medical School has developed a new technology that can non-invasively image the human lymphatic system. A fluorescent dye and commercially-available laser diode and military-grade night vision devices are used to visualize the lymphatic capillaries.

Contact: Lyndsay Meyer
lmeyer@osa.org
202-416-1435
The Optical Society

Public Release: 3-Jun-2014
Journal of Clinical Endocrinology and Metabolism
Experts recommend blood, urine testing to diagnose rare adrenal tumors
The Endocrine Society today issued a Clinical Practice Guideline for the diagnosis and treatment of two types of rare adrenal tumors -- pheochromocytomas and paragangliomas -- that can raise the risk of cardiovascular disease and even death if left untreated.

Contact: Jenni Glenn Gingery
jgingery@endocrine.org
202-971-3655
The Endocrine Society

Public Release: 3-Jun-2014
Journal of the National Cancer Institute
Study: New test predicts if breast cancer will spread
A test that counts the number of locations in tumor specimens where tumor cells may invade blood vessels predicted the risk of distant spread, or metastasis, for the most common type of breast cancer.
NIH/National Cancer Institute

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine

Public Release: 3-Jun-2014
JAMA
Moffitt researchers develop process to help personalize treatment for lung cancer patients
Moffitt Cancer Center researchers, in collaboration with the Lung Cancer Mutation Consortium, have developed a process to analyze mutated genes in lung adenocarcinoma to help better select personalized treatment options for patients. Adenocarcinoma is the most common type of lung cancer in the United States with approximately 130,000 people diagnosed each year.
NIH/National Cancer Institute

Contact: Kim Polacek
Kim.Polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 2-Jun-2014
International Journal of Radiation Oncology • Biology • Physics
Gene therapy combined with IMRT found to reduce recurrence for select prostate cancer patients
Combining oncolytic adenovirus-mediated cytotoxic gene therapy with intensity modulated radiation therapy reduces the risk of having a positive prostate biopsy two years after treatment in intermediate-risk prostate cancer without affecting patients' quality of life.

Contact: Brittany Ashcroft
press@astro.org
703-839-7336
American Society for Radiation Oncology

Public Release: 2-Jun-2014
Genes & Development
Stopping the spread of breast cancer
Scientists have discovered a new pathway that can stop breast cancer cells from spreading. Working with human cancer cells and a mouse model of breast cancer, scientists identified a new protein that plays a key role in reprogramming cancer cells to migrate and invade other organs. When that protein is removed from cancer cells in mice, the ability of the cells to metastasize to the lung is dramatically decreased.
National Institutes of Health

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University

Public Release: 2-Jun-2014
Journal of Clinical Investigation
JCI online ahead of print table of contents for June 2, 2014
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers published online, June 2, 2014 in the JCI: 'Mucin concentration contributes to a sticky situation in cystic fibrosis,' 'Engineered aptimer targets malignant and tumor-associated T cells,' 'NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB,' 'Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease,' 'Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation,' and more.

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Showing releases 1151-1175 out of 1269.

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