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Showing releases 1151-1175 out of 1369.

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Public Release: 26-Feb-2015
Cell Reports
Leukemia-associated mutations almost inevitable as we age
It's almost inevitable that we'll develop mutations associated with leukemia as we age, according to research today in Cell Reports. These mutations are more common than previously thought and their numbers increase significantly with age. Scientists analyzed DNA mutations present in minute concentrations of blood from people without leukemia. Approximately 20 percent of people aged 50-60 and more than 70 percent over 90 are thought to have cells with leukemia-associated mutations.
Wellcome Trust Clinician Scientist Fellowship, Wellcome Trust Sanger Institute, Wellcome Trust Senior Fellowship in Clinical Science, Leukaemia Lymphoma Research, Kay Kendal Leukaemia Fund, Spanish Ministerio de Economía y Competitividad

Contact: Mary Clarke
Wellcome Trust Sanger Institute

Public Release: 26-Feb-2015
Growth signal can influence cancer cells' vulnerability to drugs, study suggests
Some cells within a tumor may succumb to anti-cancer drugs, while others survive to bring back the cancer. Research at Rockefeller University explains one mechanism behind this variable vulnerability: exposure to TGF-beta, a signal that restricts growth in healthy tissue.

Contact: Wynne Parry
Rockefeller University

Public Release: 26-Feb-2015
Journal of the National Cancer Institute
Statin use associated with reduced risk of liver cancer among those in the UK
In a nested-case control study of individuals living in the UK, a part of the world with a relatively low incidence of liver cancer, statin use is associated with a decreased risk of liver cancer, according to a new study published Feb. 26 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
Oxford University Press USA

Public Release: 26-Feb-2015
Current Biology
Skeleton of cells controls cell multiplication
A research team from Instituto Gulbenkian de Ciencia, led by Florence Janody, in collaboration with Nicolas Tapon from London Research Institute, discovered that the cell's skeleton can trigger the multiplication of cells through the action of proteins that control cellular rigidity. During this process genes that promote cancer -- oncogenes -- become activated, leading to tumor formation in living organisms. This study was published in the latest edition of the scientific journal Current Biology.
Fundacao para a Ciencia e a Tecnologia, Cancer Research UK

Contact: Ana Mena
Instituto Gulbenkian de Ciencia

Public Release: 26-Feb-2015
JAMA Oncology
Patient perceptions of physician compassion measured
Cancer patients perceived a higher level of compassion and preferred physicians when they provided a more optimistic message in a clinical trial that used videos with doctors portrayed by actors, according to a study published online by JAMA Oncology.

Contact: Laura Sussman
The JAMA Network Journals

Public Release: 26-Feb-2015
Novel precision medicine tool could help personalize cancer treatments
A new laboratory test accurately predicted which of many drug treatments would most effectively kill cancer cells in the laboratory and in the clinic. If validated in ongoing clinical trials, the test could be ready to inform patient care in about two years.
National Institutes of Health

Contact: Teresa M Herbert
Dana-Farber Cancer Institute

Public Release: 26-Feb-2015
Journal of the Royal Society of Medicine
Global health experts call into question sub-Saharan cancer data
Global health experts believe the current data on cancer prevalence, incidence and mortality in sub-Saharan Africa -- which determines how billions of pounds of international development money is spent -- are weak and could mean vital funds are being deflected from other priorities. These include diarrheal and waterborne diseases, malnutrition, sanitation and the need to strengthen health systems.

Contact: Charli Scouller
Queen Mary, University of London

Public Release: 26-Feb-2015
JAMA Oncology
Blood samples as surrogates for tumor biopsies in patients with lung cancer
A study examined the feasibility of using circulating free DNA from blood samples of patients with advanced non-small-cell lung cancer as a surrogate for tumor biopsies to determine tumor-causing epidermal growth factor receptor mutations and then correlate that with expected patient outcomes, according to a study published online by JAMA Oncology.

Contact: Rafael Rosell, M.D.
The JAMA Network Journals

Public Release: 26-Feb-2015
European Journal of Cancer
Real-life study for YONDELIS® in sarcoma show comparable or better efficacy than clinical trials
The study reinforces the efficacy of YONDELIS® (trabectedin) in multiple types of soft-tissue sarcoma and supports that long-term treatment delays disease progression. Even in heavily pretreated patients, the efficacy outcomes of the drug were similar or improved compared to historical controls.
French NetSARC Network, EuroSarc

Contact: Carolina Pola

Public Release: 26-Feb-2015
JAMA Oncology
Reasons for ibrutinib therapy discontinuation in patients with chronic lymphocytic leukemia
About 10 percent of patients with chronic lymphocytic leukemia discontinued therapy with the Bruton tyrosine kinase inhibitor drug ibrutinib because of disease progression during clinical trials, according to a study published online by JAMA Oncology.

Contact: Amanda J. Harper
The JAMA Network Journals

Public Release: 25-Feb-2015
Novel anti-cancer DNA vaccine may fight aging, chronic inflammation and osteoporosis
The CureLab consortium has discovered a DNA vaccine, which systemically alleviates chronic inflammation in the body. Preventive and therapeutic effects of the new vaccine were demonstrated in osteoporosis mouse models. A paper reporting these results is just published in the journal Gerotarget. Alleviating chronic inflammation may constitute an alternative application for the CureLab vaccine, which recently demonstrated great potency as a veterinary anticancer agent and currently is in phase I of anticancer clinical trials.

Contact: Nathan Fridlyand
Cure Lab, Inc.

Public Release: 25-Feb-2015
Graphene shows potential as novel anti-cancer therapeutic strategy
University of Manchester scientists have used graphene to target and neutralize cancer stem cells while not harming other cells.

Contact: Jamie Brown
University of Manchester

Public Release: 25-Feb-2015
One in 3 women could potentially be spared chronic pain after breast cancer surgery
One in every three women undergoing a mastectomy could potentially be spared chronic post-operative pain if anesthesiologists used a regional anesthetic technique in combination with standard care, according to a new study.
Funders listed in release

Contact: Geoff Koehler
416-864-6060 x6537
St. Michael's Hospital

Public Release: 25-Feb-2015
How the landscape of the pancreatic cancer genome is coming into view
Scientists from Australia and the UK have done the most in-depth analysis yet of 100 pancreatic cancer genomes and highlighted four subtypes that may help guide future patient treatment. The study is published in Nature today.
National Health and Medical Research Council of Australia, Cancer Council NSW, Cancer Institute NSW, Queensland Government, Institute of Molecular Bioscience at the University of Queensland, Avner Nahmani Pancreatic Cancer Foundation

Contact: Alison Heather
Garvan Institute of Medical Research

Public Release: 25-Feb-2015
Nature Reviews Clinical Oncology
What does the future hold for treating patients with locally advanced breast cancer?
Treating patients with locally advanced inoperable breast cancer is an extremely difficult task. The overwhelming majority of patients treated for this disease suffer relapse and, despite the best multimodal treatment, do not survive. There is a medical need to examine current and potential treatments, and EORTC researchers have recently published an article in Nature Reviews Clinical Oncology concerning this topic.

Contact: John Bean
European Organisation for Research and Treatment of Cancer

Public Release: 25-Feb-2015
Culture clash: How stem cells are grown affects their genetic stability
Writing in the Feb. 25 online issue of the journal PLOS ONE, researchers at University of California, San Diego School of Medicine, with collaborators from The Scripps Research Institute, have definitively shown for the first time that the culture conditions in which stem cells are grown and mass-produced can affect their genetic stability.
California Institute for Regenerative Medicine, National Institutes of Health, UC San Diego Department of Reproductive Medicine, the Hartwell Foundation, Millipore Foundation, Esther O'Keefe Foundation, Marie Mayer Foundation, Autism Speaks

Contact: Scott LaFee
University of California - San Diego

Public Release: 25-Feb-2015
Shopping vouchers could help 1 in 5 pregnant women quit smoking
Financial incentives could help one in five women quit smoking during pregnancy, according to new research published today in the journal Addiction. The study, led by researchers at the University of Cambridge and King's College London, found that only a small number of women 'gamed' the system to receive the incentives whilst continuing to smoke.
NHS Derbyshire County Primary Care Trust, Derbyshire County Council, Wellcome Trust

Contact: Craig Brierley
University of Cambridge

Public Release: 25-Feb-2015
Researchers find link between inflammation, tissue regeneration and wound repair response
Writing in the Feb. 25 online issue of Nature, an international team of scientists, headed by researchers at the University of California, San Diego School of Medicine, report finding new links between inflammation and regeneration: signaling pathways that are activated by a receptor protein called gp130.
Japan Society for the Promotion of Science, Uehara Memorial Foundation, Mochida Memorial Foundation for Medical and Pharmaceutical Research, Kanae Foundation for the Promotion of Medical Science

Contact: Scott LaFee
University of California - San Diego

Public Release: 25-Feb-2015
Chemistry - A European Journal
New compound may lead to development of cheaper anti-cancer drugs
A new compound developed at the University of Toronto Scarborough could play an important role in developing cheaper anti-cancer drugs.
Natural Sciences and Engineering Research Council of Canada

Contact: Don Campbell
University of Toronto

Public Release: 25-Feb-2015
Physics in Medicine and Biology
Cherenkov Effect improves radiation therapy for patients with cancer
The characteristic blue glow from a nuclear reactor is present in radiation therapy, too. Investigators from Dartmouth's Norris Cotton Cancer Center published in Physics in Medicine and Biology how the complex parts of the blue light known as the Cherenkov Effect can be measured and used in dosimetry to make therapies safer and more effective.
National Institutes of Health

Contact: Kirk Cassels
The Geisel School of Medicine at Dartmouth

Public Release: 25-Feb-2015
Open Biology
Molecular mouse-trap technique sheds light on key cell processes
Scientists have shed new light on the fundamental biological process of cell division, thanks to an emerging analytical method.
Wellcome Trust

Contact: Catriona Kelly
University of Edinburgh

Public Release: 25-Feb-2015
Veterinary and Comparative Oncology
Study reveals possible biological trigger for canine bone cancer
Researchers at the University of Wisconsin-Madison School of Veterinary Medicine have identified the biological mechanism that may give some cancer cells the ability to form tumors in dogs. The recent study uncovered an association between the increased expression of a particular gene in tumor cells and more aggressive behavior in a form of canine bone cancer. It may also have implications for human cancers by detailing a new pathway for tumor formation.

Contact: Timothy Stein
University of Wisconsin-Madison

Public Release: 25-Feb-2015
Pediatric Blood and Cancer
Quick antibiotics reduce PICU needs and mortality of pediatric cancer patients
A University of Colorado Cancer Center study published in the journal Pediatric Blood & Cancer shows that pediatric cancer patients who receive antibiotics within 60 minutes of reporting fever and showing neutropenia (low neutrophil count), go on to have decreased intensive care needs and lower mortality compared with patients who receive antibiotics outside the 60-minute window.

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 25-Feb-2015
American Journal of Public Health
Navigators help patients overcome health-care inequities
A new study shows that guidance from trained navigators can help patients overcome health-care inequities. Community navigators worked with uninsured Spanish-speaking women to obtain timely follow-up care after an abnormal breast or cervical cancer screening result. Postponed diagnosis after an abnormal test can lead to less effective treatment and lower chances of survival.
National Institutes of Health

Contact: Marla Paul
Northwestern University

Public Release: 24-Feb-2015
Clinical Cancer Research
TGen study: Destroying tumor material that 'cloaks' cancer cells could benefit patients
Like a stealth jet cloaks itself from radar, cancer cells cloak themselves within tumors by hiding behind a dense layer of cellular material known as stroma. According to a new study by the Translational Genomics Research Institute, drugs that target and strip away the stroma would pave the way for drugs to reach the cancerous cells within the tumor, which could have a beneficial effect on the survival of pancreatic cancer patients.
NIH/National Cancer Institute, Stand Up To Cancer, Katz Family Foundation, National Foundation for Cancer Research

Contact: Steve Yozwiak
The Translational Genomics Research Institute

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