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Public Release: 1-Feb-2016
Computers, Informatics, Nursing
When loved ones battle cancer, families head to Web for information more than support
Loved ones of cancer patients are likely to search for further information about the disease online but less inclined to seek emotional support from social media forums, according to a University of Georgia study. It is fairly common for loved ones of cancer patients to develop depression or anxiety disorders, but there aren't many studies focusing specifically on cancer patients' caregivers and family members, said the study's author, Carolyn Lauckner.
Michigan State University's College of Communication Arts and Sciences

Contact: Stephanie Schupska
University of Georgia

Public Release: 1-Feb-2016
'BPA-free' plastic accelerates embryonic development, disrupts reproductive system
Companies advertise 'BPA-free' as a safer version of plastic products ranging from water bottles to sippy cups to toys. Yet a new UCLA study demonstrates that BPS, a common replacement for BPA, speeds up embryonic development and disrupts the reproductive system. The research is the first to examine the effects of BPA and BPS on key brain cells and genes that control organs involved in reproduction.
UCLA, National Natural Science Foundation of China, Program for Innovative Research Team in University

Contact: Elaine Schmidt
University of California - Los Angeles Health Sciences

Public Release: 1-Feb-2016
Nature Genetics
Abnormal gene is a triple threat in driving pediatric brain tumors
Oncology researchers have discovered that an abnormal fused gene that drives pediatric brain tumors poses a triple threat, operating simultaneously through three distinct biological mechanisms -- the first such example in cancer biology. This finding potentially offers triple benefits as well -- more accurate diagnoses, clues for more effective treatments and new insights into molecular processes underlying other types of cancer.
National Institutes of Health, A Kids' Brain Tumor Cure Foundation/Pediatric Low-Grade Astrocytoma Foundation, Voices Against Brain Cancer, Thea's Star of Hope, Why Not Me Inc.

Contact: John Ascenzi
Children's Hospital of Philadelphia

Public Release: 1-Feb-2016
Proceedings of the National Academy of Sciences
Cancer cells travel together to forge 'successful' metastases
There's apparently safety in numbers, even for cancer cells. New research in mice suggests that cancer cells rarely form metastatic tumors on their own, preferring to travel in groups since collaboration seems to increase their collective chances of survival, according to researchers at Johns Hopkins.
US Department of Defense, Burroughs Wellcome Fund, American Cancer Society, NIH/National Cancer Institute, Mary Kay Ash Foundation, Cindy Rosencrans Fund for Triple Negative Breast Cancer Research, Metastatic Breast Cancer Network, and others

Contact: Catherine Gara
Johns Hopkins Medicine

Public Release: 1-Feb-2016
10-fold difference worldwide in new cases of, and deaths from, bowel cancer
There's a 10-fold difference worldwide in the numbers of new cases of bowel cancer and deaths from the disease, finds research published online in the journal Gut.

Contact: Caroline White

Public Release: 1-Feb-2016
Cancer Epidemiology, Biomarkers & Prevention
Appalachia continues to have higher cancer rates than the rest of US but gap is narrowing
Men and women in Appalachia continue to have higher cancer incidence rates compared with those in the rest of the United States regardless of race or location. The disparity is attributed in part to high tobacco use, potential differences in socioeconomic status, and patient health care utilization.
Centers for Disease Control and Prevention

Contact: Lauren Riley
American Association for Cancer Research

Public Release: 1-Feb-2016
Higher dietary fiber intake in young women may reduce breast cancer risk
Boston, MA - Women who eat more high-fiber foods during adolescence and young adulthood--especially lots of fruits and vegetables--may have significantly lower breast cancer risk than those who eat less dietary fiber when young, according to a new large-scale study led by researchers at Harvard T.H. Chan School of Public Health.
National Institutes of Health, The Breast Cancer Research Foundation, Japan Pharmaceutical Manufacturers Association

Contact: Marge Dwyer
Harvard T.H. Chan School of Public Health

Public Release: 1-Feb-2016
Nature Genetics
Genetic cause identified in rare pediatric brain tumor
Researchers found a way of differentiating angiocentric gliomas from other low-grade pediatric brain tumors and developed a pathological test that will help children avoid unnecessary and potentially damaging additional therapies.
A Kids' Brain Tumor Cure Foundation Pediatric Low-Grade Astrocytoma Foundation, National Institutes of Health

Contact: Teresa Herbert
Dana-Farber Cancer Institute

Public Release: 1-Feb-2016
Proceedings of the National Academy of Sciences
Shedding new light on breast cancer metastasis
It has long been thought that cancer metastasizes, or spreads, when a single cancer cell escapes from the original tumor, travels through the bloodstream and sets up shop in distant organs. However, a growing body of evidence suggests that these bad actors don't travel alone; instead they migrate through the body in cellular clusters, like gangs.
US Department of Defense, Burroughs Wellcome Fund, American Cancer Society, NIH/National Cancer Institute, Mary Kay Ash Foundation, Cindy Rosencrans Fund for Triple Negative Breast Cancer Research

Contact: Kristen Woodward
Fred Hutchinson Cancer Research Center

Public Release: 1-Feb-2016
Journal of Clinical Oncology
Does radiation therapy improve survival for women with ductal carcinoma in situ?
Investigators from Brigham and Women's Hospital (BWH) and the Dana-Farber Cancer Institute have found that a set of easily measurable risk factors can predict the magnitude of survival benefit offered by radiation therapy following breast cancer surgery. Their results appear online in The Journal of Clinical Oncology on Feb. 1.
National Institutes of Health

Contact: Haley Bridger
Brigham and Women's Hospital

Public Release: 1-Feb-2016
Journal of Women's Health
Preventing cardiovascular disease in women -- one physician's approach to juggling the many guidelines
Nanette K. Wenger, M.D., Professor of Medicine (Cardiology) Emeritus, Emory University School of Medicine, provides a comprehensive perspective on how to apply the many new and continuously updated guidelines for preventing cardiovascular disease (CVD) and reducing CVD risk factors in women, in a clear and concise review article published in Journal of Women's Health.

Contact: Kathryn Ryan
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 1-Feb-2016
Cell Reports
Researchers identify potential targeted therapy for lung cancer using fly model
A drug approved by the Food and Drug Administration for melanoma in combination with a common cholesterol-lowering drug may show promise in controlling cancer growth in patients with non-small cell lung cancer, according to new research from the Icahn School of Medicine at Mount Sinai.
National Institutes of Health

Contact: Lucia Lee
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 1-Feb-2016
European Physical Journal Plus
Physical parameters matter in terms of cancer cells' metastatic ability
The micro-environment surrounding cancer cells is just as important as genes in regulating tumor progression. Scientists have therefore examined the biophysical and biochemical cues occurring in the vicinity of cancer cells. This represents a departure from the traditional measurement of secreted molecules, called biomarkers.

Contact: Sabine Lehr

Public Release: 1-Feb-2016
Obstetrics & Gynecology
Sparing ovaries and removing fallopian tubes may cut cancer risk, but few have procedure
During hysterectomies for non-cancerous conditions, removing both fallopian tubes while keeping the ovaries may help protect against ovarian cancer and preserve hormonal levels, but few women receive this surgical option, according to a new study by Yale School of Medicine researchers.

Contact: Karen N. Peart
Yale University

Public Release: 1-Feb-2016
Proceedings of the National Academy of Sciences
A 'gap in the armor' of DNA may allow enzyme to trigger cancer-causing mutations
Research from Indiana University published in the Proceedings of the National Academy of Sciences has identified a genetic mechanism that is likely to drive mutations that can lead to cancer.
US Army Research Office, National Institutes of Health

Contact: Kevin D. Fryling
Indiana University

Public Release: 1-Feb-2016
British Journal of Pharmacology
Cancer drug helps combat asthma in mice
In a mouse model of allergic asthma, dasatinib -- an enzyme inhibitor approved for the treatment of chronic myelogenous leukemia -- reduced inflammation, enhanced airway repair, and improved lung mechanics.

Contact: Dawn Peters

Public Release: 1-Feb-2016
BJU International
Targeted antibiotics may help protect against infections in men being tested for prostate cancer
A new review indicates that antimicrobial therapy given before clinicians take transrectal ultrasound-guided prostate biopsies to diagnose prostate cancer may lead to lower rates of sepsis, a potentially life-threatening infection.

Contact: Dawn Peters

Public Release: 1-Feb-2016
Americans favor a tax increase to support the 'moonshot' cancer initiative
Vice President Joe Biden's 'moonshot' initiative to defeat cancer earns support for a tax increase to fund cancer research among half of respondents (50 percent) in a new national public opinion survey commissioned by Research!America. Thirty-eight percent disagree and an additional 12 percent are not sure. A significant majority of Democrats (67 percent), and more than a third of Republicans (38 percent) and Independents (39 percent) support a tax increase, and support is particularly strong among Americans ages 18 - 49.

Contact: Anna Briseno

Public Release: 29-Jan-2016
Nature Communications
Vital clues to future cancer development in normal breast tissue DNA
Detecting molecular alterations in early breast cancer development is key in the development of more effective cancer prevention and early detection strategies. New research funded by the Eve Appeal and the European Union's Seventh Framework Program, published today in science journal Nature Communications shows clear evidence that DNA changes are already present in the healthy tissue from women with breast cancer.
Eve Appeal, European Union's Seventh Framework Program

Contact: Wesley Hutchins
University College London

Public Release: 29-Jan-2016
Journal of the National Cancer Institute
Oncologists issue guidance for allocating scarce chemotherapy drugs
Claiming that clinicians lack formal and concrete allocation guidance when faced with a critical drug shortage, experts in pediatric oncology and bioethics have issued a framework to avoid waste and guide difficult prioritization decisions among children in need of scarce life-saving chemotherapy treatment. The commentary is published Jan. 29 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
Oxford University Press USA

Public Release: 29-Jan-2016
Lancet Oncology
Proton therapy controls common pediatric brain tumor with fewer long-term side effects
The use of proton radiotherapy to treat the most common malignant brain tumor in children is as effective as standard photon (X-ray) radiation therapy while causing fewer long-term side effects such as hearing loss and cognitive disorders.
NIH/National Cancer Institute

Contact: Katie Marquedant
Massachusetts General Hospital

Public Release: 29-Jan-2016
Plastic and Reconstructive Surgery
Fat injection for breast reconstruction doesn't increase risk of recurrent breast cancer
For women undergoing breast cancer surgery, a technique called lipofilling -- using the patient's own fat cells to optimize the results of breast reconstruction -- does not increase the risk of recurrent breast cancer, reports a study in the February issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons.

Contact: Connie Hughes
Wolters Kluwer Health

Public Release: 29-Jan-2016
Molecular Cancer Therapeutics
A new class of drug slows growth of castration-resistant prostate cancer cells
Sphingosine kinase inhibitors are a new category of drugs that act on specific enzymes involved in sphingolipid metabolism to reduce the formation of a pro-cancer, pro-inflammatory lipid signaling molecule known as sphingosine-1 phosphate (S1P). Preclinical studies led by immunologist Christina Voelkel-Johnson, Ph.D., of the Medical University of South Carolina showed that a first-in-class sphingosine kinase 2 inhibitor slowed growth of aggressive prostate cancer cells.
The MUSC Hollings Cancer Center's Cancer Center Support Grant, Medical University of South Carolina, National Center for Research Resources, Office of the Director of the National Institututes of Health

Contact: Heather Woolwine
Medical University of South Carolina

Public Release: 29-Jan-2016
Technology and Innovation
Spotlight on both old, difficult issues and humanitarian visions that drive new patents
The current issue of Technology and Innovation has articles on the 2015 Patents for Humanity Awards, asbestos exposure during outdoor recreational activities, the phenomenon of academic serial inventors, and a special section on regulatory science with articles on organic vs. conventional foods and the critical role of review criteria in peer review.

Contact: Kimberly Macuare
University of South Florida (USF Innovation)

Public Release: 28-Jan-2016
Leukemia & Lymphoma
Standard BMI inadequate for tracking obesity during leukemia therapy
An interdisciplinary research team at The Saban Research Institute of Children's Hospital Los Angeles has found that body mass index (BMI) is an inadequate method for estimating changes in body fat and obesity in children with leukemia. Investigators determined that the discrepancy between BMI and body composition was due to increases in body fat with simultaneous loss of lean muscle mass during treatment.
National Center for Advancing Translational Sciences, Leukemia and Lymphoma Society, Hyundai Hope on Wheels Foundation, Saban Research Institute

Contact: Ellin Kavanagh
Children's Hospital Los Angeles

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