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Public Release: 2-Mar-2016
How diet influences colon cancer
A study ties high-fat diet to changes in intestinal stem cells and may help explain increased cancer risk.

Contact: Abby Abazorius
Massachusetts Institute of Technology

Public Release: 2-Mar-2016
High-fat diet linked to intestinal stem cell changes, increased risk for cancer
Over the past decade, studies have found that obesity and eating a high-fat, high-calorie diet are significant risk factors for many types of cancer. Now, a new study from Whitehead Institute and MIT's Koch Institute for Integrative Cancer Research reveals how a high-fat diet makes the cells of the intestinal lining more likely to become cancerous.
National Institutes of Health, US Department of Defense, Howard Hughes Medical Institute, Ellison Medical Foundation, American Federation of Aging Research, Kathy and Curt Marble Cancer Research Fund, V Foundation

Contact: Matt Fearer
Whitehead Institute for Biomedical Research

Public Release: 2-Mar-2016
Possible link found between radiotherapy for prostate cancer and risk of secondary cancers
Researchers have found a possible association between radiotherapy for the treatment of prostate cancer and an increased risk of developing secondary cancers of the bladder, colorectal tract, and rectum. Their study is published in The BMJ today.

Contact: Emma Dickinson

Public Release: 2-Mar-2016
Scientific Reports
Cancer treatment on a cellular level
The most common treatments for cancer are radiation and chemotherapy. However they have side effects and also damage healthy tissues. Moreover, their effectiveness is limited when the cancer has spread through out the body. Researchers at the Niels Bohr Institute are therefore working to develop a gentler treatment that 'tricks' the cancer cells, which would absorb a cytotoxin and therefore be destroyed, while healthy cells would remain unaffected.

Contact: Gertie Skaarup
University of Copenhagen - Niels Bohr Institute

Public Release: 2-Mar-2016
Vitamin D deficiency contributes to spread of breast cancer in mice, Stanford study finds
Breast tumors in laboratory mice deficient in vitamin D grow faster and are more likely to metastasize than tumors in mice with adequate levels of vitamin D, according to a preliminary study by researchers at the Stanford University School of Medicine.

Contact: Krista Conger
Stanford University Medical Center

Public Release: 2-Mar-2016
ACS Central Science
Toward diagnosing diseases such as cancer in their earliest stages
Detecting diseases such as cancer in their earliest stages can make a huge difference in patient treatment, but it is often difficult to do. Now scientists report in the journal ACS Central Science a new, simple method that could make early disease diagnosis much easier. In addition, their approach only requires a minute sample of patient blood and is 1,000 times more sensitive in detecting biomarkers for thyroid cancer than the current government-approved test.

Contact: Michael Bernstein
American Chemical Society

Public Release: 2-Mar-2016
Genes & Development
Ottawa researchers find Achilles' heel of a severe form of childhood leukemia
Researchers at The Ottawa Hospital and the University of Ottawa have found the Achilles' heel of one of the most aggressive forms of leukemia that affects both children and adults. They have also identified a possible new treatment that exploits this fatal weakness.
Canadian Institutes of Health Research, NIH/National Institute of Diabetes and Digestive and Kidney Diseases, Fonds de recherche du Québec en Santé, Ontario Ministry of Research and Innovation, and others

Contact: Amelia Buchanan, Senior Communication Specialist, Ottawa Hos
613-798-5555 x73687
Ottawa Hospital Research Institute

Public Release: 2-Mar-2016
Science Translational Medicine
A new weapon in the fight against children's brain tumors developed at U-M
Children with brain cancer may soon get some help from mice with the same disease, thanks to a new brain tumor model in mice that should make it easier to test treatments.
NIH/National Institute for Neurological Diseases and Stroke, NIH/National Cancer Institute, St. Baldrick's Foundation Fellowship, Alex's Lemonade Stand Foundation/Northwestern Mutual Young Investigator Grant

Contact: Kara Gavin
University of Michigan Health System

Public Release: 2-Mar-2016
Lancet Oncology
Drug combination slows breast cancer spread
A combination of two drugs delays progression of advanced, aggressive breast cancer by an average of nine months -- working in all subsets of the most common type of breast cancer. The combination -- of a first-in-class targeted drug called palbociclib, and the hormone drug fulvestrant -- slowed cancer growth in around two thirds of women with advanced forms of the most common type of breast cancer.

Contact: Henry French
Institute of Cancer Research

Public Release: 2-Mar-2016
JAMA Dermatology
Study of patients with melanoma finds most have few moles
Most patients with melanoma had few moles and no atypical moles, and in patients younger than 60, thick melanomas were more commonly found in those with fewer moles but more atypical moles, according to an article published online by JAMA Dermatology.

Contact: Todd Datz
The JAMA Network Journals

Public Release: 2-Mar-2016
Breast cancer: The mental trauma of severe disease
According to a study led by Ludwig-Maximilians-Universitaet in Munich researchers, a majority of patients diagnosed with breast cancer go on to develop symptoms of post-traumatic stress disorder, and in most of these cases the symptoms persist for at least a year.

Contact: Luise Dirscherl
Ludwig-Maximilians-Universität München

Public Release: 2-Mar-2016
Proceedings of the National Academy of Sciences
Cancer cells' evasive action revealed
Researchers identify a mechanism by which lung cancer cells evade the body's immune system.
US Department of Defense, NIH/National Cancer Institute Early Detection Program, Canary Foundation, Leukemia and Lymphoma Society Translational Research Program and National Institutes of Health

Contact: David Ruth
Rice University

Public Release: 2-Mar-2016
Study explores how high-fat diet influences colon cancer
A study published in Nature reveals how a high-fat diet makes the cells of the intestinal lining more likely to become cancerous. The new study of mice suggests that a high-fat diet drives a population boom of intestinal stem cells and also generates a pool of other cells that behave like stem cells -- that is, they can reproduce themselves indefinitely and differentiate into other cell types. These stem cells and 'stem-like' cells are more likely to give rise to intestinal tumors.
Howard Hughes Medical Institute, Ellison Medical Foundation, National Institutes of Health, US Department of Defense, Center for the Study of Inflammatory Bowel Diseases at Massachusetts General Hospital, Kathy and Curt Marble Cancer Research Fund

Contact: Irene Sege
Dana-Farber Cancer Institute

Public Release: 2-Mar-2016
Lancet Oncology
New, less toxic therapy for stage-4 breast cancer
For women suffering from stage-4 breast cancer, there is a new treatment plan that, according to a recent Northwestern Medicine clinical trial, is highly effective and has minimal toxicity. The treatment includes a drug recently approved by the US Food and Drug Administration.

Contact: Kristin Samuelson
Northwestern University

Public Release: 1-Mar-2016
Breast Cancer Research
Engineered hydrogel scaffolds enable growth of functioning human breast tissue
Whitehead Institute researchers have created a hydrogel scaffold that replicates the environment found within the human breast. The scaffold supports the growth of human mammary tissue from patient-derived cells and can be used to study normal breast development as well as breast cancer initiation and progression.
National Science Foundation Graduate Research Fellowships Program

Contact: Nicole Giese Rura
Whitehead Institute for Biomedical Research

Public Release: 1-Mar-2016
Clinical Cancer Research
New biomarker identifies uveal melanoma patients at high risk for metastasis
A study by J. William Harbour, M.D., associate director for Basic Research and leader of the Eye Cancer Site Disease Group at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and colleagues published today in Clinical Cancer Research details the discovery of a biomarker that puts patients at a higher risk for metastasis of uveal melanoma.
National Institutes of Health, NIH/National Cancer Institute, Research to Prevent Blindness, Melanoma Research Alliance, Melanoma Research Foundation, 2015 AACR-Ocular Melanoma Foundation Fellowship, Department of Defense

Contact: Patrick Bartosch
University of Miami Miller School of Medicine

Public Release: 1-Mar-2016
Genome Medicine
Successful precision medicine will require more accurate genome sequencing
Large areas of medically important genes fall within troublesome regions of the human genome, where it is currently difficult to obtain accurate sequence information, according to research published in the open access journal Genome Medicine. On average, one-fifth of each of these medically important genes is challenging for today's gene sequencing methods to decipher, and the information in these gene regions may be key to a patient's diagnosis or treatment plan.

Contact: Alanna Orpen
BioMed Central

Public Release: 1-Mar-2016
British Journal of Cancer
Ethnic minority women more likely to believe that cancer is deadly and down to fate
Women from ethnic minorities in the UK are more likely to believe that cancer is incurable and is down to fate than their white counterparts, according to a Cancer Research UK study published in the British Journal of Cancer today.

Contact: Emily Head
Cancer Research UK

Public Release: 1-Mar-2016
Better biopsies through biofluidics
Biopsies are a gold standard for definitively diagnosing diseases like cancer. Usually, doctors can only take 2-D snapshots of the tissue, and they're limited in their ability to measure the protein levels that might better explain a diagnosis. But now, researchers have developed a new method to acquire 3-D atlases of tissue that provide much more information, incorporating both data on the tissue structure and its molecular profile. They report their results in Biomicrofluidics.

Contact: Jason Socrates Bardi
American Institute of Physics

Public Release: 1-Mar-2016
Genome Medicine
Study highlights need for better characterized genomes for clinical sequencing
Challenges in benchmarking difficult, but clinically important regions of the genome are reported in today's issue of Genome Medicine. The results underscore the need to extend benchmarking references against which sequencing data and analyses can be compared and validated.

Contact: Mark Bello
National Institute of Standards and Technology (NIST)

Public Release: 1-Mar-2016
Cold Spring Harbor Molecular Case Studies
From Molecular Case Studies: Novel gene variants identified in male breast cancer
Male breast cancer (MBC) is a very rare tumor type, occurring in just 1 percent of all breast cancer cases, and the underlying genetic causes and treatment of MBC is not well understood. In a paper published in the March issue of Cold Spring Harbor Molecular Case Studies, researchers from Italy and the US describe novel genetic variants found in a hormone receptor positive (HR+) MBC patient, that are distinct from previously identified genetic variants found in 10 MBC cases.
Associazione Italiana per la Ricerca sul Cancro

Contact: Peggy Calicchia
Cold Spring Harbor Laboratory

Public Release: 1-Mar-2016
FASEB Journal
Beta blockers may lead to new novel triple negative breast cancer treatments
New research published in the March 2016 issue of The FASEB Journal, shows that a commonly prescribed class of high blood pressure drugs may have the potential to slow the growth of triple negative breast cancer tumors. These drugs, called 'beta blockers' work by counteracting the pro-growth effect caused by adrenaline by affecting the the beta2-adrenoceptor.

Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Public Release: 1-Mar-2016
Journal of the National Cancer Institute
Early MRI screening reduces risk of breast cancer death for survivors of childhood HL
Researchers at Princess Margaret Cancer Centre have confirmed in a screening effectiveness study that early screening with MRIs can reduce breast cancer mortality for female survivors of childhood Hodgkin's lymphoma (HL) who received chest radiation.
Canadian Cancer Society, Pediatric Oncology Group of Ontario, Cancer Care Ontario, Princess Margaret Cancer Foundation

Contact: Danielle Pereira
416-946-4501 x4011
University Health Network

Public Release: 1-Mar-2016
Journal of Clinical Oncology
Low vitamin D predicts aggressive prostate cancer
A new study provides a major link between low levels of vitamin D and aggressive prostate cancer. Northwestern Medicine research showed deficient vitamin D blood levels in men can predict aggressive prostate cancer identified at the time of surgery. The finding is important because it can offer guidance to men and their doctors who may be considering active surveillance, in which they monitor the cancer rather than remove the prostate
National Institutes of Health, US Department of Defense, Veterans Administration

Contact: Marla Paul
Northwestern University

Public Release: 29-Feb-2016
Journal of Clinical Investigation
Study may widen patient pool that benefits from EPZ-5676 against acute myeloid leukemia
A University of Colorado Cancer Center study published today in the Journal of Clinical Investigation unpacks mechanism that gene MN1 uses to cause an aggressive AML subtype. Drugs targeting weak link in the chain of causation are in clinical trials for other subtypes.
National Institutes of Health, NIH/National Cancer Institute, Doris-Duke Charitable Foundation

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

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