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Public Release: 27-Mar-2014
Cell Reports
Scientists find potential target for treating mitochondrial disorders
Whitehead Institute scientists have identified a protein whose inhibition could hold the key to alleviating suffering caused by mitochondrial disorders found in cancer, Parkinson's disease, Alzheimer's disease, and mitochondrial diseases.
National Institutes of Health, David H. Koch Institute for Integrative Cancer Research, Alexander and Margaret Stewart Trust Fund

Contact: Nicole Giese Rura
Whitehead Institute for Biomedical Research

Public Release: 26-Mar-2014
ELCC 2014 European Lung Cancer Conference
Journal of Thoracic Oncology
Immunotherapy data heralds new era of lung cancer treatment
A new era of lung cancer therapy is close to dawning, using drugs that can prevent tumor cells from evading the immune system, experts say at the 4th European Lung Cancer Congress.

Contact: Press Office
European Society for Medical Oncology

Public Release: 26-Mar-2014
Society of Interventional Radiology 39th Annual Scientific Meeting
3-D MRI scans may offer better way to predict survival after chemo for liver tumors
In a series of studies involving 140 American men and women with liver tumors, researchers at Johns Hopkins have used specialized 3-D MRI scans to precisely measure living and dying tumor tissue to quickly show whether highly toxic chemotherapy -- delivered directly through a tumor's blood supply -- is working.
NIH/National Cancer Institute, NIH/National Center for Research Resources

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 26-Mar-2014
BJU International
Certain genetic variants may put bladder cancer patients at increased risk of recurrence
In the Western world, bladder cancer is the fourth most common cancer in men and the eighth most common in women, with many patients experiencing recurrence after treatment. A new study published in BJU International indicates that inheriting certain DNA sequences can affect a patient's prognosis.

Contact: Evelyn Martinez

Public Release: 26-Mar-2014
Journal of Nutritional Biochemistry
Eat a peach
A Washington State University food scientist and colleagues at Texas A&M have found that compounds in peaches can inhibit the growth of breast cancer cells and their ability to spread.

Contact: Giuliana Noratto
Washington State University

Public Release: 26-Mar-2014
Science Translational Medicine
Some breast cancer tumors hijack patient epigenetic machinery to evade drug therapy
A breast cancer therapy that blocks estrogen synthesis to activate cancer-killing genes sometimes loses its effectiveness because the cancer takes over epigenetic mechanisms, including permanent DNA modifications in the patient's tumor, once again allowing tumor growth, according to an international team headed by the University of Pittsburgh Cancer Institute.
Alexander von Humboldt Foundation, US Department of Defense, National Institutes of Health, Susan G. Komen Foundation

Contact: Allison Hydzik
University of Pittsburgh Schools of the Health Sciences

Public Release: 26-Mar-2014
New England Journal of Medicine
New drug successfully treats crizotinib-resistant, ALK-positive lung cancer
Now a new drug called ceritinib appears to be effective against advanced ALK-positive non-small cell lung cancer, both in tumors that have become resistant to crizotinib and in those never treated with the older drug.
Novartis, NIH/National Cancer Institute, V Foundation for Cancer Research, Be a Piece of the Solution, Evan Spirito Memorial Founndation

Contact: Katie Marquedant
Massachusetts General Hospital

Public Release: 26-Mar-2014
European Journal of Pharmacology
Natural plant compounds may assist chemotherapy
Researchers at Plant & Food Research have identified plant compounds present in carrots and parsley that may one day support more effective delivery of chemotherapy treatments.

Contact: Mike Shaw
New Zealand Institute for Plant and Food Research

Public Release: 26-Mar-2014
45th Annual Meeting on Women's Cancer
Research: Less invasive technique possible in vulvar cancer treatment
A team of researchers from Women & Infants Hospital of Rhode Island commanded a national stage to present the results of a study evaluating the use of sentinel lymph node dissection in women with vulvar malignancies, and then follow the patients for complications and recurrence.

Contact: Susan McDonald
Women & Infants Hospital

Public Release: 26-Mar-2014
Journal of Nuclear Medicine
Preoperative PET cuts unnecessary lung surgeries in half
A comprehensive statistical analysis reveals PET changed patient management in 50 percent of lung cancer cases.

Contact: Eleanore Tapscott
Society of Nuclear Medicine

Public Release: 26-Mar-2014
UT Southwestern cancer biologists link tumor suppressor gene to stem cells
Just as archeologists try to decipher ancient tablets to discern their meaning, UT Southwestern Medical Center cancer biologists are working to decode the purpose of an ancient gene considered one of the most important in cancer research.
Cancer Prevention and Research Institute of Texas, Ellison Foundation, NIH/National Institute of General Medical Sciences, Welch Foundation

Contact: Patrick McGee
UT Southwestern Medical Center

Public Release: 26-Mar-2014
Kif15: The acrobatic motor protein that could pave the way for new cancer therapies
Researchers at Warwick Medical School have shown for the first time how a protein motor, Kif15, uses acrobatic flexibility to navigate within the mitotic spindle. Understanding how it works could prove vital for the development of targeted cancer therapies.
Marie Curie Cancer Care

Contact: Luke Harrison
University of Warwick

Public Release: 26-Mar-2014
American Association for Cancer Research (AACR) Annual Meeting 2014
Albert Einstein College of Medicine researchers present at AACR Annual Meeting symposia
From uncovering the role nerve cells play in metastasis to identifying new cancer-causing genes, researchers at Albert Einstein College of Medicine of Yeshiva University made notable advances in the understanding and potential treatment of cancer during the past year. Several Einstein faculty members and students will present their recent research at the American Association for Cancer Research (AACR) Annual Meeting, taking place in San Diego April 5-9, 2014.

Contact: Kim Newman
Albert Einstein College of Medicine

Public Release: 25-Mar-2014
European Physical Journal D
Plasma tool for destroying cancer cells
Plasma medicine is a new and rapidly developing area of medical technology. Specifically, understanding the interaction of so-called atmospheric pressure plasma jets with biological tissues could help to use them in medical practice. Under the supervision of Sylwia Ptasinska, Xu Han and colleagues conducted a quantitative and qualitative study of the different types of DNA damage induced by atmospheric pressure plasma exposure. The paper is published in European Physical Journal D.
National Science Foundation

Contact: Saskia Rohmer

Public Release: 25-Mar-2014
Treatment helps reduce risk of esophagus disorder progressing to cancer
Among patients with the condition known as Barrett's esophagus, treatment of abnormal cells with radiofrequency ablation (use of heat applied through an endoscope to destroy cells) resulted in a reduced risk of this condition progressing to cancer, according to a study in the March 26 issue of JAMA.

Contact: Jacques J. Bergman, M.D., Ph.D.
The JAMA Network Journals

Public Release: 25-Mar-2014
The Lancet Oncology
Doxorubicin alone or with ifosfamide for treating soft tissue sarcoma?
An EORTC study published in The Lancet Oncology does not support administration of intensified doxorubicin and ifosfamide for palliation of advanced soft tissue sarcoma, unless the objective is to shrink the tumor.
Cancer Research UK, European Organisation for Research and Treatment of Cancer Charitable Trust, United Kingdom National Health Service, Canadian Cancer Society Research Institute, Amgen

Contact: John Bean
European Organisation for Research and Treatment of Cancer

Public Release: 25-Mar-2014
Journal of Clinical Oncology
Twenty-five percent of breast cancer survivors report financial decline due to treatment
Four years after being treated for breast cancer, a quarter of survivors say they are worse off financially, at least partly because of their treatment, according to a new study led by University of Michigan Comprehensive Cancer Center researchers.
NIH/National Cancer Institute, American Cancer Society

Contact: Nicole Fawcett
University of Michigan Health System

Public Release: 25-Mar-2014
Angewandte Chemie International Edition
New drug raises potential for cancer treatment revolution
A revolution in cancer treatment could soon be underway following a breakthrough by the University of Warwick that may lead to a dramatic improvement in cancer survival rates.

Contact: Tom Frew
University of Warwick

Public Release: 25-Mar-2014
Journal of Clinical Investigation
JCI online ahead of print table of contents for March 25, 2014
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers published online, March 25, 2014 in the JCI: 'Epigenetic alterations disrupt intestinal T cell homeostasis,' 'Researchers develop a conditionally immortalized human β cell line, PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors,' 'Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo,' 'Leptin-promoted cilia assembly is critical for normal energy balance,' and more.

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 25-Mar-2014
Journal of Nutritional Biochemistry
Texas researcher: Peaches inhibit breast cancer metastasis in mice
Lab tests at Texas A&M AgriLife Research have shown that treatments with peach extract inhibit breast cancer metastasis in mice.
Vegetable and Fruit Improvement Center at Texas A&M, US Department of Agriculture, California Tree Fruit Agreement

Contact: Kathleen Phillips
Texas A&M AgriLife Communications

Public Release: 24-Mar-2014
Use of mood-stabilizing drug linked with reduced risk of developing head and neck cancer
A new study indicates that a commonly used mood stabilizing drug may help prevent head and neck cancer. The study is published early online in Cancer, a peer-reviewed journal of the American Cancer Society.

Contact: Evelyn Martinez

Public Release: 24-Mar-2014
Gene implicated in progression and relapse of deadly breast cancer finding points to potential Achilles' heel in triple negative breast cancer
Scientists from Weill Cornell Medical College and Houston Methodist have found that a gene previously unassociated with breast cancer plays a pivotal role in the growth and progression of the triple negative form of the disease, a particularly deadly strain that often has few treatment options. Their research, published in this week's Nature, suggests that targeting the gene may be a new approach to treating the disease.

Contact: Jen Gundersen
Weill Cornell Medical College

Public Release: 24-Mar-2014
Clinical Genetics
Researchers issue state-of-the-state on genetic-based testing and treatment for breast cancer
Dartmouth researchers at its Norris Cotton Cancer Center have compiled a review of the role that information gathered through genetic testing plays in the diagnosis and treatment of breast cancer. The paper entitled 'Personalized Therapy for Breast Cancer' was accepted on March 17, 2014, for publication in Clinical Genetics. The paper discusses targeted therapies, new biomarkers, and the quality of commercially available testing methods.

Contact: Donna Dubuc
The Geisel School of Medicine at Dartmouth

Public Release: 24-Mar-2014
Bundled payments come to gastroenterology
Patients want physicians to provide high-quality care and the health system requires good value for physician work. To help gastroenterologists achieve these goals, the American Gastroenterological Association (AGA) has developed a colonoscopy bundled payment model, which has been published in Gastroenterology, the official journal of the AGA.

Contact: Aimee Frank
American Gastroenterological Association

Public Release: 24-Mar-2014
Advanced Functional Materials
Hot nanoparticles for cancer treatments
Nanoparticles have a great deal of potential in medicine: for diagnostics, as a vehicle for active substances or a tool to kill off tumours using heat. ETH Zurich researchers have now developed particles that are relatively easy to produce and have a wide range of applications.

Contact: Georgios Sotiriou
ETH Zurich

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