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Showing releases 1151-1175 out of 1296.

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Public Release: 8-Sep-2015
American Journal of Pathology
Biomarker helps predict survival time in gastric cancer patients
Gastric cancer poses a significant health problem in developing countries and is typically associated with late-stage diagnosis and high mortality. A new study in The American Journal of Pathology points to a pivotal role played by the biomarker microRNA (miR)-506 in gastric cancer. Patients whose primary gastric cancer lesions express high levels of miR-506 have significantly longer survival times compared to patients with low miR-506 expression. In addition, miR-506 suppresses tumor growth, blood vessel formation, and metastasis.
National Natural Science Foundation of China, Scientific Research Project of the Department of Education of Yunnan Province, Leading Talent of Health Systems of Yunnan Province

Contact: Eileen Leahy
Elsevier Health Sciences

Public Release: 8-Sep-2015
Scientific Reports
Nature: Study creates cell immunity to parasite that infects 50 million
Multi-institution, multidisciplinary study applies cancer science technique to field of infectious diseases to pinpoint human genes that allow parasite E. histolytica to cause cell death.
National Institutes of Health

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 8-Sep-2015
Health Affairs
Global health studies in September Health Affairs
The September issue of Health Affairs includes articles examining the growing burden of noncommunicable diseases, both in the United States and elsewhere.

Contact: Amy Martin Vogt
Health Affairs

Public Release: 8-Sep-2015
2015 Annual Meeting & OTO EXPO
Otolaryngology-Head and Neck Surgery
Physicians highlight ENT research to be presented during otolaryngology's annual meeting
Abstracts of research to be presented at the 2015 Annual Meeting & OTO EXPO? of the American Academy of Otolaryngology--Head and Neck Surgery Foundation are now available.

Contact: Lindsey Walter
American Academy of Otolaryngology - Head and Neck Surgery

Public Release: 8-Sep-2015
CA: A Cancer Journal for Clinicians
New guidelines address long-term needs of colorectal cancer survivors
New American Cancer Society Cancer Survivorship Care guidelines released today provide primary care clinicians with recommendations for providing comprehensive care to the estimated 1.2 million survivors of colorectal cancer in the United States.

Contact: David Sampson
American Cancer Society

Public Release: 8-Sep-2015
JAMA Pediatrics
E-cigarettes serve as smoking gateway for teens and young adults, Pitt-Dartmouth study finds
Young people across the United States who smoke electronic cigarettes are considerably more likely to start smoking traditional cigarettes within a year than their peers who do not smoke e-cigarettes, according to an analysis led by the University of Pittsburgh Center for Research on Media, Technology, and Health and the Dartmouth-Hitchcock Norris Cotton Cancer Center.
NIH/National Cancer Institute, NIH/National Center for Advancing Translational Sciences

Contact: John Cramer
Dartmouth College

Public Release: 8-Sep-2015
Pharmacology Research & Perspectives
New drug-like compounds may improve odds of men battling prostate cancer, researchers find
Researchers at Southern Methodist University, Dallas, have discovered new drug-like compounds that could ultimately be developed into medicines that offer better odds of survival to prostate cancer patients. The new compounds target the human protein P-gp, which causes resistance against a majority of the drugs currently available for treating cancer and HIV/AIDS. The new compounds, discovered via computer-generated models, are good candidates for development into drugs since the compounds have low toxicity to noncancerous cells.
National Institutes of Health, NIH/National Institute of General Medical Sciences, Communities Foundation of Texas, Southern Methodist University

Contact: Margaret Allen
Southern Methodist University

Public Release: 8-Sep-2015
Stem Cell Reports
Researchers develop a method for controlling gene activation
University of Helsinki researchers have developed a new method which enables the activation of genes in a cell without changing the genome. Applications of the method include directing the differentiation of stem cells. The research was published in the Stem Cell Reports journal.

Contact: Timo Otonkoski
University of Helsinki

Public Release: 8-Sep-2015
Increased detection of low-risk tumors driving up thyroid cancer rates, Mayo study finds
Low-risk cancers that do not have any symptoms and presumably will not cause problems in the future are responsible for the rapid increase in the number of new cases of thyroid cancer diagnosed over the past decade, according to a Mayo Clinic study published in the journal Thyroid. According to the study authors, nearly one-third of these recent cases were diagnosed when clinicians used high-tech imaging even when no symptoms of thyroid disease were present.

Contact: Joe Dangor
Mayo Clinic

Public Release: 8-Sep-2015
16th World Conference on Lung Cancer
CTCA study shows characterization of lung micro-organisms could help lung cancer patients
A study of microbes that inhabit human lungs and how they may relate to the development of lung cancer, led by Cancer Treatment Centers of America at Western Regional Medical Center in Goodyear, Arizona, was presented today in Denver during the 16th World Conference on Lung Cancer. Dr. Glen Weiss, Director of Clinical Research and Medical Oncologist at CTCA at Western presented the study at today's WCLC poster session on Biology, Pathology and Molecular Testing.

Contact: Steve Yozwiak
Cancer Treatment Centers of America

Public Release: 8-Sep-2015
Angewandte Chemie
Researchers find new clue to halting leukemia relapse
Rice researchers identify and validate a new molecular mechanism of action to overcome drug resistance in patients with acute myeloid leukemia.
National Institutes of Health, Robert A. Welch Foundation, National Science Foundation, Virginia and L.E. Simmons Family Foundation

Contact: David Ruth
Rice University

Public Release: 7-Sep-2015
Nature Methods
Mathematical 'Gingko trees' reveal mutations in single cells that characterize diseases
Scientists at CSHL publish a new interactive analysis program called Gingko that reduces the uncertainty of single-cell analysis and provides a simple way to visualize patterns in copy number mutations across populations of cells. Detailed knowledge of CNVs can point to specific treatment regimens.
National Institutes of Health, National Science Foundation, Starr Cancer Consortium, Breast Cancer Research Foundation, Simons Foundation, Susan G. Komen Foundation, Prostate Cancer Foundation, CSHL Cancer Center, WSBS

Contact: Peter Tarr
Cold Spring Harbor Laboratory

Public Release: 7-Sep-2015
Study shows common molecular tool kit shared by organisms across the tree of life
Researchers have discovered the assembly instructions for nearly 1,000 protein complexes shared by most kinds of animals, revealing their deep evolutionary relationships. Those instructions offer a powerful new tool for studying the causes of diseases such as Alzheimer's, Parkinson's and cancer.
Canadian Institutes of Health Research, National Institutes of Health, National Science Foundation, Welch Foundation, Natural Sciences and Engineering Research Council of Canada, and others

Contact: Chris Cervini
University of Texas at Austin

Public Release: 7-Sep-2015
Angewandte Chemie International Edition
Dangerous bacterial enzymes become important tools for protein chemistry
A research group at Umeå University, together with researchers in Munich, have identified two enzymes from the pathogenic Legionella bacteria that are very useful in chemically modifying proteins for them to be used in medical drugs. The result of the study is presented in the chemical journal Angewandte Chemie International Edition.

Contact: Ingrid Söderbergh
Umea University

Public Release: 7-Sep-2015
Rare melanoma carries unprecedented burden of mutations
A rare, deadly form of skin cancer known as desmoplasmic melanoma may possess the highest burden of gene mutations of any cancer.

Contact: Nicholas Weiler
University of California - San Francisco

Public Release: 7-Sep-2015
16th World Conference on Lung Cancer
IASLC issues new statement on tobacco control and smoking cessation
The International Association for the Study of Lung Cancer today issued a new statement on Tobacco Control and Smoking Cessation at the 16th World Conference on Lung Cancer in Denver. The statement calls for higher taxes on tobacco products, comprehensive advertising and promotion bans of all tobacco products and product regulation including pack warnings.

Contact: Jeff Wolf
International Association for the Study of Lung Cancer

Public Release: 4-Sep-2015
Deutsches Ärzteblatt International
Esophageal cancer: Positron emission tomography does not improve treatment
Increasingly positron emission tomography is being used to monitor the size of the tumor during the radiological treatment of esophageal cancer. To date, however, no benefit for patients has ensued, as Milly Schröer-Günther and co-authors show in an original article in the current issue of Deutsches Ärzteblatt International.

Contact: Dr. rer. medic. Milly Schröer-Günther
Deutsches Aerzteblatt International

Public Release: 3-Sep-2015
JAMA Oncology
Study finds increased risk of MGUS in Vietnam Vets exposed to Agent Orange
A study that used stored blood samples from US Air Force personnel who conducted aerial herbicide spray missions of Agent Orange during the Vietnam war found a more than two-fold increased risk of the precursor to multiple myeloma known as monoclonal gammopathy of undetermined significance (MGUS), according to an article published online by JAMA Oncology.

Contact: Rebecca Williams
The JAMA Network Journals

Public Release: 3-Sep-2015
American Journal of Transplantation
Drug for fungal infections in lung transplant recipients increases risk for cancer, death
Voriconazole, a prescription drug commonly used to treat fungal infections in lung transplant recipients, significantly increases the risk for skin cancer and even death, according to a new study by UCSF researchers.

Contact: Scott Maier
University of California - San Francisco

Public Release: 3-Sep-2015
Aspirin could hold the key to supercharged cancer immunotherapy
Giving cancer patients aspirin at the same time as immunotherapy could dramatically boost the effectiveness of the treatment, according to new research published in the journal Cell.
Cancer Research UK

Contact: Greg Jones
Cancer Research UK

Public Release: 3-Sep-2015
Molecular Cell
Team decodes structure of protein complex active in DNA repair
The multifunctional ubiquitin tweaks the activity of newly made proteins, which can influence DNA damage repair via BRCA1 and anti-inflammatory responses. One enzyme in particular, BRCC36, removes a specific type of ubiquitin central to DNA damage repair and inflammation. But BRCC36 doesn't act on its own. It's part of a complex with KIAA0157. How these two work together is finally coming into focus.
NIH/National Cancer Institute, NIH/National Institute of General Medical Sciences, Harrington Discovery Institute Scholar-Innovator Award, Abramson Family Cancer Research Institute, Basser Center for BRCA, Canadian Institutes of Health Research

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 3-Sep-2015
Nature Communications
Targeting newly discovered pathway sensitizes tumors to radiation and chemotherapy
In some patients, aggressive cancers can become resistant to chemotherapy and radiation treatments. In a paper published in the journal Nature Communications, University of California, San Diego School of Medicine researchers identified a pathway that causes the resistance and a new therapeutic drug that targets this pathway.
National Institutes of Health, California Breast Cancer Research Foundation IDEA Award and ACS IRG

Contact: Scott LaFee
University of California - San Diego

Public Release: 3-Sep-2015
Journal of Clinical Oncology
Acupuncture reduces hot flashes in breast cancer survivors
Acupuncture may be a viable treatment for women experiencing hot flashes as a result of estrogen-targeting therapies to treat breast cancer, according to a new study. Hot flashes are particularly severe and frequent in breast cancer survivors, but current FDA-approved remedies for these unpleasant episodes, such as hormone replacement therapies are off-limits to breast cancer survivors because they include estrogen. The results of the study are published this week in the Journal of Clinical Oncology.
National Institutes of Health

Contact: Katie Delach
University of Pennsylvania School of Medicine

Public Release: 3-Sep-2015
New role for an old protein: Cancer causer
A protein known to play a role in transporting the molecular contents of normal cells into and out of various intracellular compartments can also turn such cells cancerous by stimulating a key growth-control pathway.
National Institutes of Health, Starr Cancer Consortium Award, US Department of Defense

Contact: Matt Fearer
Whitehead Institute for Biomedical Research

Public Release: 3-Sep-2015
Variations in cell programs control cancer and normal stem cells
In the breast, cancer stem cells and normal stem cells can arise from different cell types and tap into distinct yet related stem cell programs, according to Whitehead Institute researchers. The differences between these stem cell programs may be significant enough to be exploited by future therapeutics.
National Research Foundation, Singapore, American Cancer Society, Ludwig Foundation, Breast Cancer Research Foundation, National Cancer Institute Program, Samuel Waxman Cancer Research

Contact: Nicole Giese Rura
Whitehead Institute for Biomedical Research

Showing releases 1151-1175 out of 1296.

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