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Showing releases 1151-1175 out of 1243.

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Public Release: 16-Mar-2014
American Chemical Society 247th National Meeting & Exposition
Major 'third-hand smoke' compound causes DNA damage -- and potentially cancer
Leftover cigarette smoke that clings to walls and furniture is a smelly nuisance, but now research suggests that it could pose a far more serious threat, especially to young children who put toys and other smoke-affected items into their mouths. Scientists reported today at the 247th National Meeting & Exposition of the American Chemical Society that one of the tobacco-specific nitrosamines newly formed in 'third-hand smoke' damages DNA and could potentially cause cancer.

Contact: Michael Bernstein
American Chemical Society

Public Release: 14-Mar-2014
Clinical Cancer Research
Dartmouth researchers develop new approach to chronic lymphocytic leukemia treatment
Dartmouth researchers have developed a novel and unique approach to treating Chronic Lymphocytic Leukemia (CLL), a form of blood cancer that often requires repeated chemotherapy treatments to which it grows resistant. The researchers modeled the lymph node microenvironment where CLL cells are found in the laboratory. They were able to disrupt the activity of a pathway that ensures the survival and resistance of the CLL cells in such microenvironments.
NIH/National Cancer Institute, Leukemia & Lymphoma Society

Contact: Robin Dutcher
The Geisel School of Medicine at Dartmouth

Public Release: 14-Mar-2014
Annals of Surgical Oncology
New findings show link between diabetes and pancreatic cancer
Researchers from the University of Melbourne have shown that there is an association between pancreatic cancer and diabetes.

Contact: Anne Rahilly
University of Melbourne

Public Release: 14-Mar-2014
Physical Chemistry Chemical Physics
Big data tackles tiny molecular machines
Rice University researchers combine genetic and structural data to begin to solve one of the most compelling mysteries in biology: how proteins perform the regulatory mechanisms in cells upon which life depends.
Welch Foundation, National Science Foundation, Cancer Prevention and Research Institute of Texas

Contact: David Ruth
Rice University

Public Release: 14-Mar-2014
In the lab, scientists coax E. coli to resist radiation damage
Capitalizing on the ability of an organism to evolve in response to punishment from a hostile environment, scientists have coaxed the model bacterium Escherichia coli to dramatically resist ionizing radiation and, in the process, reveal the genetic mechanisms that make the feat possible.
National Institutes of Health, US Department of Energy

Contact: Michael Cox
University of Wisconsin-Madison

Public Release: 13-Mar-2014
Cell Reports
A versatile mouse that can teach us about many diseases and drugs
Scientists from the UK and Australia have created a mouse that expresses a fluorescing 'biosensor' in every cell of its body, allowing diseased cells and drugs to be tracked and evaluated in real time and in three dimensions.
Biotechnology and Biological Sciences Research Council

Contact: Alison Heather
Garvan Institute of Medical Research

Public Release: 13-Mar-2014
Cancer Discovery
Bladder cancer Pt with rare genetic mutations shows exceptional response to everolimus
A patient with advanced bladder cancer experienced a complete response for 14 months to the drug combination everolimus and pazopanib in a phase I trial, and genomic profiling of his tumor revealed two alterations that may have caused this exceptional response, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.
Next Generation Fund, NIH/National Human Genome Research Institute, GSK, Novartis

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 13-Mar-2014
Scripps Research Institute scientists discover a better way to make unnatural amino acids
Chemists at the Scripps Research Institute have devised a greatly improved technique for making amino acids not found in nature. These 'unnatural' amino acids traditionally have been very difficult to synthesize but are sought after by the pharmaceutical industry for their potential medical uses.
NIH/National Institute of General Medical Sciences, Bristol-Myers Squibb

Contact: Mika Ono
Scripps Research Institute

Public Release: 13-Mar-2014
Cancer Discovery
Genomic testing links 'exceptional' drug response to rare mutations in bladder cancer
A patient with advanced bladder cancer in a phase I trial had a complete response for 14 months to a combination of the targeted drugs everolimus and pazopanib, report scientists led by a Dana-Farber Cancer Institute researcher, and genomic profiling of his tumor revealed two alterations that may have led to this exceptional response.
Next Generation Fund, Broad Institute of MIT and Harvard, the National Human Genome Research Institute

Contact: Teresa Herbert
Dana-Farber Cancer Institute

Public Release: 13-Mar-2014
72nd Annual Scientific Meeting of the American Psychosomatic Society
Mindfulness-based meditation helps teenagers with cancer
Mindfulness-based meditation could lessen some symptoms associated with cancer in teens, according to the results of a clinical trial intervention led by researchers at the University of Montreal and its affiliated Centre Hospitalier Universitaire Sainte-Justine children's hospital.

Contact: William Raillant-Clark
University of Montreal

Public Release: 13-Mar-2014
New view of tumors' evolution
MIT researchers find that the sequencing of cancer cell genomes reveals potential new drug targets for an aggressive type of lung cancer.
Massachusetts Institute of Technology/Ludwig Center for Molecular Oncology, Howard Hughes Medical Institute, NIH/National Human Genome Research Institute, NIH/National Cancer Institute, Hope Funds for Cancer Research

Contact: Sarah McDonnell
Massachusetts Institute of Technology

Public Release: 13-Mar-2014
Cell Reports
A gene family that suppresses prostate cancer
Cornell University researchers report they have discovered direct genetic evidence that a family of genes, called microRNA-34, are bona fide tumor suppressors.
National Institutes of Health, New York State Stem Cell Science, Deutsche Krebshilfe

Contact: Joe Schwartz
Cornell University

Public Release: 13-Mar-2014
PLOS Pathogens
Microorganism shows promise in inhibiting thrush
Scientists at Case Western Reserve School of Medicine and University Hospitals Case Medical Center have discovered how the beneficial fungal yeast, Pichia, holds at bay a harmful fungal yeast, Candida. The hope for this finding is that components in Pichia could one day become therapeutic agents to stave off not only thrush, but also other life-threatening systemic fungal infections.

Contact: Jeannette Spalding
Case Western Reserve University

Public Release: 13-Mar-2014
Frontiers in Oncology
Study proposes new ovarian cancer targets
Proteins called TAFs were once thought to be generic cogs in the machinery of gene expression, but in a new study Brown University scientists propose that they may be important suspects in the progression of ovarian cancer that should not continue to be overlooked.
National Institutes of Health, American Cancer Society, Canadian Institutes of Health

Contact: David Orenstein
Brown University

Public Release: 13-Mar-2014
Journal of Urology
Prostate specific antigen screening declines after 2012 USPSTF recommendations
Researchers at Case Western Reserve University and University Hospitals Case Medical Center have assessed the impact of the 2012 US Preventive Services Task Force recommendations against routine prostate specific antigen (PSA) cancer screenings, which cited evidence that the risks of screening outweigh the benefits. Results of the current study indicate that the USPSTF recommendations have resulted in a decrease in the number of PSA screenings ordered by doctors, with the greatest decline seen among urologists.

Contact: Linda Gruner
Elsevier Health Sciences

Public Release: 13-Mar-2014
67th SSO Annual Cancer Symposium
Pancreatic cancer surgery findings presented at SSO
Despite the benefits of surgery for early stage pancreatic cancer, it remains under-utilized for patients with this deadly disease, according to a new national analysis of trends and outcomes. Physician-scientists at University Hospitals Case Medical Center and Case Western Reserve University School of Medicine presented their findings and strategies to increase rates at the Society of Surgical Oncology Cancer Symposium in Phoenix.

Contact: Alicia Reale
University Hospitals Case Medical Center

Public Release: 13-Mar-2014
Journal of Cell Biology
'Velcro protein' found to play surprising role in cell migration
Studying epithelial cells, the cell type that most commonly turns cancerous, Johns Hopkins researchers have identified a protein that causes cells to release from their neighbors and migrate away from healthy mammary, or breast, tissue in mice. They also found that deletion of a cellular 'Velcro protein' does not cause the single-celled migration expected. Their results, they say, help clarify the molecular changes required for cancer cells to metastasize.
American Cancer Society, NIH/National Cancer Institute, NIH/National Institute of General Medical Sciences, NIH/National Center for Research Resources, Safeway, Avon, Hay Graduate Award, Kleberg Foundation

Contact: Catherine Kolf
Johns Hopkins Medicine

Public Release: 12-Mar-2014
JAMA Psychiatry
Nicotine withdrawal weakens brain connections tied to self-control over cigarette cravings
A new brain imaging study in this week's JAMA Psychiatry from scientists in Penn Medicine and the National Institute on Drug Abuse Intramural Research Program shows how smokers suffering from nicotine withdrawal may have more trouble shifting from a key brain network -- known as default mode, when people are in a so-called 'introspective' state -- and into a control network that could help exert more self-control over cravings and to focus on quitting for good.
NIH/National Cancer Institute, NIH/National Institute on Drug Abuse

Contact: Steve Graff
University of Pennsylvania School of Medicine

Public Release: 12-Mar-2014
Journal of Lipid Research
Breast cancer gene could play critical role in obesity and diabetes
The gene known to be associated with breast cancer susceptibility, BRCA 1, plays a critical role in the normal metabolic function of skeletal muscle, according to a new study led by kinesiology researchers in the University of Maryland School of Public Health. Mutations in the BRCA1 gene may also put people at increased risk for metabolic diseases like obesity and type 2 diabetes.

Contact: Kelly Blake
University of Maryland

Public Release: 12-Mar-2014
Researchers destroy cancer with cryoablation & nanoparticle-encapsulated anticancer drug
Combining nanodrug-based chemotherapy and cryoablation provides an effective strategy to eliminate cancer stem-like cells the root of cancer resistance and metastasis, which will help to improve the safety and efficacy of treating malignancies that are refractory to conventional therapies.
American Cancer Society Research Scholar Grant, SUCCESS College of Medicine at Ohio State University

Contact: Chew Munkit
65-646-65775 x261
World Scientific

Public Release: 12-Mar-2014
Journal of Oncology Practice
Transition to ICD-10 may cause information, financial losses for providers
The study, appearing in the March issue of the Journal of Oncology Practice, looked at coding ambiguity for hematology-oncology diagnoses to anticipate challenges all providers may face during the transition from ICD-9-CM to ICD-10-CM.

Contact: Sherri McGinnis Gonzalez
University of Illinois at Chicago

Public Release: 12-Mar-2014
Nature Structural & Molecular Biology
Protein key to cell motility has implications for stopping cancer metastasis
A Penn team describes how a key cell-movement protein called IRSp53 is regulated in a resting and active state, and what this means for cancer-cell metastasis. They characterized how IRSp53 connects to the cell-motility machinery by starting the formation of cell filopodia.
National Institutes of Health, American Cancer Society

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 11-Mar-2014
Antibody could be used to target tumor-causing protein, study shows
Cincinnati Cancer Center and University of Cincinnati Cancer Institute researchers have found in a phase-1 study that patients with advanced melanoma and kidney cancer who were treated with a certain antibody that targets a tumor-enhancing protein was safe, which could lead to more treatment options for patients.
Genzyme Corporation, NIH/National Cancer Institute

Contact: Katie Pence
University of Cincinnati Academic Health Center

Public Release: 11-Mar-2014
Cancer Research
The immune system's redesigned role in fighting cancerous tumors
Researchers in the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute eradicated solid tumors in laboratory mice using a novel combination of two targeted agents. These two synergistic therapies stimulate an immune response, ultimately allowing solid tumors to act as their own cancer-fighting vaccine.

Contact: Cara Martinez
Cedars-Sinai Medical Center

Public Release: 11-Mar-2014
Journal of Pediatric Oncology Nursing
Lack of sleep, stress describe a mother's experience after child's ALL treatment
Many months after their child's diagnosis and treatment, 46 percent of mothers exhibited symptoms of clinical anxiety and 26 percent of mothers showed depressive symptoms.
NIH/National Cancer Institute

Contact: Garth Sundem
University of Colorado Denver

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