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Public Release: 18-Dec-2015
PLOS Genetics
BAP1 mutation passed down over centuries and is associated with high incidence of several cancers
Carbone and colleagues discovered that members of 4 families, apparently unrelated and living in different US States, shared the identical mutation of a gene called BAP1 that is associated with a higher incidence of mesothelioma, melanoma, renal carcinoma and other cancers. Through genetic and genealogical studies, it was demonstrated that the families were related, and that they descended from a couple that immigrated to the USA from Germany in the early 1700s.
National Institutes of Health, Department of Defense Congressionally Directed Medical Research Programs Peer Reviewed Cancer Research Program Career Development Award, V Foundation, University of Hawai'i Cancer Center

Contact: Amy Yau
ayau@plos.org
44-122-344-2823
PLOS

Public Release: 18-Dec-2015
Oncotarget
New model for vascular and tumor research
Two characteristic features of malignant tumors are that they form massive blood vessels and bypass the immune system. A new cell culture technique allows the processes of tumor growth to be studied directly and in real time, without the need for complex experiments using live animals. The researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg who developed the technique looked specifically at brain tumors.

Contact: Dr. Nicolai Savaskan
nicolai.savaskan@uk-erlangen.de
49-913-185-49000
University of Erlangen-Nuremberg

Public Release: 18-Dec-2015
Journal of General Internal Medicine
Uncovering potentially 'concerning' variation in cancer screening follow-ups
According to new study of one million patients, follow-up times for colorectal cancer screening abnormalities lag behind those for breast and cervical cancers.

Contact: Paige Stein
Paige.Stein@Darmouth.edu
603-653-1971
The Dartmouth Institute for Health Policy & Clinical Practice

Public Release: 17-Dec-2015
Lancet
Study suggests that annual CA125 screening may reduce ovarian cancer deaths
Initial results from the world's largest ovarian cancer screening trial suggest that tracking levels of a cancer-associated protein over time may help reduce ovarian cancer deaths as much as 20 percent. The trial investigated whether annual screening with a blood test utilizing the Risk of Ovarian Cancer Algorithm, co-developed a Massachusetts General Hospital biostatistician, can reduce ovarian cancer deaths.
Medical Research Council, Cancer Research U.K., U.K. Department of Health, The Eve Appeal, National Cancer Institute

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital

Public Release: 17-Dec-2015
JAMA Oncology
Younger age associated with increased likelihood of targetable genotype in lung cancer
Patients younger than 50 diagnosed with non-small-cell lung cancer had a higher likelihood of having a targetable genomic alteration for which therapies exist, according to an article published online by JAMA Oncology.

Contact: Anne Doerr
anne_doerr@dfci.harvard.edu
617-632-4090
The JAMA Network Journals

Public Release: 17-Dec-2015
Analyst
New test for cancer and diabetes biomarkers 1000x more detailed
A new test for detecting biomarkers for cancer and diabetes is more than 1000x more detailed and 100 percent faster than existing methods, new research by the University of Warwick suggests. Developed to undertake a detailed study of collagen, the researchers argue that the same methodology can be used with any protein-based sample and is currently being tested with cancer cells and proteins relevant to Type II diabetes.

Contact: Tom Frew
a.t.frew@warwick.ac.uk
44-024-767-75910
University of Warwick

Public Release: 17-Dec-2015
JAMA Oncology
When cancer of unknown origin strikes, patient's family members face increased risk
Family members of patients with cancers of unknown origin have a higher risk for getting those and other types of cancers.
NIH/National Cancer Institute, Huntsman Cancer Foundation, American College of Gastroenterology

Contact: Linda Aagard
801-587-7639
University of Utah Health Sciences

Public Release: 17-Dec-2015
Lancet
First evidence to suggest that screening for ovarian cancer may save lives
New results from the world's biggest ovarian cancer screening trial led by UCL suggest that screening based on an annual blood test may help reduce the number of women dying from the disease by around 20 percent. The research, published today (Thursday) in the Lancet, also cautions that longer follow up is needed to establish more certain estimates of how many deaths from ovarian cancer could be prevented by screening.
UK Medical Research Council, Cancer Research UK, UK Department of Health, Eve Appeal

Contact: Harry Dayantis
h.dayantis@ucl.ac.uk
44-203-108-3844
University College London

Public Release: 17-Dec-2015
Chemistry and Biology
Probing the mystery of how cancer cells die
A new study sheds light on the role sphingolipids play in the death of cancer cells. The research traces how levels of various sphingolipids spike inside cancer cells when the cells are undergoing a highly organized form of cellular death called apoptosis.

Contact: Charlotte Hsu
chsu22@buffalo.edu
716-645-4655
University at Buffalo

Public Release: 17-Dec-2015
Science
A gene for new species is discovered
A University of Utah-led study identified a long-sought 'hybrid inviability gene' responsible for dead or infertile offspring when two species of fruit flies mate with each other. The discovery sheds light on the genetic and molecular process leading to formation of new species, and may provide clues to how cancer develops.
Howard Hughes Medical Institute, Life Sciences Research Foundation, National Institutes of Health, National Science Foundation, Mathers Foundation, and others

Contact: Lee J. Siegel
lee.siegel@utah.edu
801-244-5399
University of Utah

Public Release: 17-Dec-2015
JAMA Oncology
Lung cancer found to be genetically different disease in young and older patients
Non-small cell lung cancer (NSCLC) in younger patients is a distinct disease, genetically and biologically, from NSCLC in older patients and may require a different treatment approach, Dana-Farber Cancer Institute scientists have found.
National Institutes of Health, American Society of Clinical Oncology/Conquer Cancer Foundation, Bonnie J. Addario Lung Cancer Foundation, Canadian Institutes of Health Research, Canadian Association of Medical Oncologists, others

Contact: Anne Doerr
anne_doerr@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute

Public Release: 17-Dec-2015
Journal of Comparative Effectiveness Research
Journal of Comparative Effectiveness research discusses oncology treatment sequences
Future Science Group (FSG) today announced the publication of a new article in the Journal of Comparative Effectiveness Research, discussing the recent recommendations from the Center for Medical Technology Policy's (CMTP) Green Park Collaborative (GPC-USA). The recommendations, released in August, discuss the conduct of studies that compare sequences of therapies in areas of advanced and metastatic cancer where a range of therapeutic options exist, but evidence is lacking on the optimal choices for sequential or combination therapy.

Contact: Leela Ripton
l.ripton@future-science-group.com
44-208-371-6090
Future Science Group

Public Release: 17-Dec-2015
Cell
Experiments explain the events behind molecular 'bomb' seen in cancer cells
Sometimes, in cancer cells, a part of a chromosome looks like it has been pulverized, then put back together incorrectly, leading to multiple mutations. New research from The Rockefeller University describes the cellular events leading to this molecular explosion, which serves as a precursor to cancer.

Contact: Katherine Fenz
kfenz@rockefeller.edu
212-327-7913
Rockefeller University

Public Release: 17-Dec-2015
Cancer drives patients to poverty in Southeast Asia
Five percent of cancer patients and their families were pushed into poverty in Southeast Asia between March 2012 and Sep. 2013, because of high disease-related costs, a study (1) at the inaugural ESMO Asia 2015 Congress in Singapore shows.

Contact: ESMO Press Office
media@esmo.org
European Society for Medical Oncology

Public Release: 17-Dec-2015
Angewandte Chemie
Pinpoint targeting instead of shotgun approach
Integrins help cells communicate with and adapt to their environment. Also cancer cells depend on their properties to survive and spread throughout the body. Now scientists at the Technical University of Munich (TUM) have successfully developed a small, highly active molecule that binds to a specific integrin that operates in many types of cancer. In the future it may allow patient-specific diagnoses and subsequent targeted treatment of tumor cells.
German Research Foundation

Contact: Dr. Andreas Battenberg
battenberg@zv.tum.de
49-892-891-0510
Technical University of Munich (TUM)

Public Release: 17-Dec-2015
Cancer Research
Prostate cancer discovery may make it easier to kill cancer cells
A newly discovered connection between two common prostate cancer treatments may soon make prostate cancer cells easier to destroy. Drugs that could capitalize on the discovery are already in the pipeline.
NIH/National Cancer Institute, Paul Mellon Urologic Cancer Institute

Contact: Josh Barney
jdb9a@virginia.edu
434-906-8864
University of Virginia Health System

Public Release: 17-Dec-2015
Journal of Urology
Mental health status prior to bladder cancer surgery can indicate risk of complications
A patient's mental health prior to surgery can influence postoperative outcomes. Removal of the bladder, or radical cystectomy (RC), is an effective treatment for locally advanced bladder cancer, but complications occur in as many as 66% of patients. In a study in The Journal of Urology®, researchers found that patients whose self-assessment of mental health was low suffered more high grade complications in the 30 days following surgery than patients with higher self-assessments.

Contact: Linda Gruner
jumedia@elsevier.com
212-633-3923
Elsevier Health Sciences

Public Release: 17-Dec-2015
Gastrointestinal Endoscopy
Endoscopic techniques offer hope for throat cancer patients
According to a study in the December issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE), endoscopic submucosal dissection (ESD) appears to be a safe and effective minimally invasive treatment for patients with superficial pharyngeal (throat) cancer.

Contact: Gina Steiner
gsteiner@asge.org
630-570-5635
American Society for Gastrointestinal Endoscopy

Public Release: 17-Dec-2015
Journal of Personalized Medicine
NYU nursing study examines obesity in relation to breast cancer related lymphedema
Lymphedema is a major health problem negatively affecting many breast cancer survivors survivors' quality of life. NYU researchers have shown this condition can be managed with early and appropriate treatment.
NIH/National Institute of Nursing Research, NIH/National Institute on Minority Health and Health Disparities

Contact: christopher james
christopher.james@nyu.edu
212-229-7936
New York University

Public Release: 17-Dec-2015
Journal of NeuroInterventional Surgery
'Smart fat cells' cross blood-brain barrier to catch early brain tumors
An MRI contrast agent that can pass through the blood-brain barrier will allow doctors to detect deadly brain tumors called gliomas earlier, say Penn State College of Medicine researchers. This ability opens the door to make this fatal cancer treatable.
Tara Leah Witmer Memorial Fund

Contact: Matt Solovey
msolovey@hmc.psu.edu
717-531-8606
Penn State

Public Release: 17-Dec-2015
Immuno & targeted therapy provide new options for difficult-to-treat head&neck cancer
Novel strategies are on the way for difficult-to-treat and advanced head and neck cancer, the most heterogeneous group of malignancies which are generally associated with poor survival, and encouraging results have been presented at the first ESMO Asia 2015 Congress in Singapore.

Contact: ESMO Press Office
media@esmo.org
European Society for Medical Oncology

Public Release: 17-Dec-2015
Annals of Oncology
Pancreas cancer liquid biopsy flows from blood-borne packets of tumor genes
Pancreatic cancer tumors spill their molecular secrets into the blood stream, shedding their complete DNA and RNA wrapped inside protective lipid particles that make them ripe for analysis with a liquid biopsy, researchers at The University of Texas MD Anderson Cancer Center report online at the Annals of Oncology.

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center

Public Release: 17-Dec-2015
Epigenomics
FSG publishes report by Esteller et al. validating new Illumina MethylationEPIC BEadChip
Epigenomics, the MEDLINE-indexed journal published by Future Science Group, is excited to announce the publication of the first study validating the MethylationEPIC BEadChip microarray -- the new and improved DNA methylation array from Illumina (CA, USA). The validation of this array provides the research community with a powerful new method for elucidating the role of the human epigenome in health and disease.

Contact: Leela Ripton
l.ripton@future-science-group.com
44-208-371-6090
Future Science Group

Public Release: 17-Dec-2015
Science
Architecture of mTOR protein complex solved
For a long time it has been known that the protein TOR - Target of Rapamycin -- controls cell growth and is involved in the development of diseases such as cancer and diabetes. Researchers at the University of Basel's Biozentrum together with scientists from ETH Zurich have now examined the structure of mammalian TOR complex 1 (mTORC1) in more detail. The scientists have revealed its unique architecture in their latest publication in Science.

Contact: Katrin Bühler
katrin.buehler@unibas.ch
41-612-670-974
University of Basel

Public Release: 16-Dec-2015
Neurosurgery
Study shows multiple-dose, targeted radiation more effective for treating pituitary tumors
A recent patient study at Houston Methodist Hospital proved that multiple small doses of highly focused radiation therapy is safer and more effective than a single larger dose of radiation at destroying pituitary gland tumors.

Contact: Katie Wooldridge
kjwooldridge@houstonmethodist.org
713-816-2215
Houston Methodist

Showing releases 1151-1175 out of 1348.

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