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Public Release: 31-Oct-2013
International Journal of Radiation Oncology Biology Physics
Largest ever study of male breast cancer treatment shows more mastectomy, less radiation than in female disease
University of Colorado Cancer Center researchers used data from 4,276 cases of male breast cancer and 718,587 cases of female breast cancer to show that the disease is treated differently in men than in women. Specifically, male breast cancer is treated with mastectomy more often than female breast cancer, and in cases in which locally advanced female breast cancer is commonly treated with radiation, the treatment is less used in the male disease.

Contact: Garth Sundem
University of Colorado Denver

Public Release: 31-Oct-2013
Current Biology
Cellular tail length tells disease tale
Simon Fraser University molecular biologist Lynne Quarmby's adventures in pond scum have led her and four student researchers to discover a mutation that can make cilia, the microscopic antennae on our cells, grow too long. When the antennae aren't the right size, the signals captured by them get misinterpreted. The result can be fatal. They have discovered that the regulatory gene CNK2 is present in cilia and controls the length of these hair-like projections.

Contact: Carol Thorbes
Simon Fraser University

Public Release: 31-Oct-2013
Study offers new theory of cancer development
Researchers have devised a way to understand patterns of aneuploidy -- an abnormal number of chromosomes -- in tumors and predict which genes in the affected chromosomes are likely to be cancer suppressors or promoters. They propose that aneuploidy is a driver of cancer rather than a result of it.
US Department of Defense, National Institutes of Health, Howard Hughes Medical Institute

Contact: David Cameron
Harvard Medical School

Public Release: 31-Oct-2013
Journal of Clinical Investigation
Newly identified proteins make promising targets for blocking graft-vs.-host disease
Researchers from the University of Michigan Comprehensive Cancer Center have identified new proteins that control the function of critical immune cell subsets called T-cells, which are responsible for a serious and often deadly side effect of lifesaving bone marrow transplants.
National Institutes of Health, Leukemia Lymphoma Society, American Society of Transplantation

Contact: Nicole Fawcett
University of Michigan Health System

Public Release: 30-Oct-2013
Cancer Prevention Research
MUHC researchers identify biomarkers that could lead to early diagnosis of colorectal cancer
Diagnosing colorectal cancer is complex; it relies on significant invasive tests and subjective evaluations. This process may soon become much easier thanks to a medical breakthrough by the Research Institute of the McGill University Health Centre. The researchers have identified genetic changes in the colon lining, or mucosa, in colorectal cancer patients that could be used as biomarkers of the disease. That will allow doctors to diagnose patients earlier, more accurately and less invasively.
Canadian Institutes of Health Research

Contact: Julie Robert
514-934-1934 x71381
McGill University Health Centre

Public Release: 30-Oct-2013
Scientists call for action to tackle 'alarmingly' low survival of Kenyan women with cervical cancer
Less than 7 percent of cervical cancer patients in Kenya are getting the optimum treatment needed to eradicate the disease, leading to unnecessary deaths -- a study by The University of Manchester scientists reveals. Results from the research, which looked retrospectively at the treatment of women diagnosed with cervical cancer during a two year period, showed 18 percent of cervical cancer patients in the East African country died within two years of a diagnosis.

Contact: Alison Barbuti
University of Manchester

Public Release: 30-Oct-2013
Journal of Cancer Survivorship
Qigong can help fight fatigue in prostate cancer survivors
Flowing movements and meditative exercises of the mind-body activity Qigong may help survivors of prostate cancer to combat fatigue. These are the findings of a study by Dr. Anita Y. Kinney at the University of New Mexico Cancer Center and Dr. Rebecca Campo at the University of North Carolina at Chapel Hill. The study took place at the Huntsman Cancer Institute at the University of Utah, and was published in Springer's Journal of Cancer Survivorship.
NIH/National Center for Complementary and Alternative Medicine, University of Utah/Center on Aging Pilot Award

Contact: Joan Robinson

Public Release: 30-Oct-2013
New England Journal of Medicine
NEJM study evaluates early stem cell transplants for non-Hodgkin's lymphoma
Performing early stem cell transplants in patients with aggressive non-Hodgkin's lymphoma does not improve overall survival in high-risk patients, according to a study published in the New England Journal of Medicine. But early transplantation does appear to be beneficial among a small group of patients who are at the very highest risk, the study found.
NIH/National Cancer Institute

Contact: Jim Ritter
Loyola University Health System

Public Release: 30-Oct-2013
Science Translational Medicine
Incurable brain cancer gene is silenced
Glioblastoma multiforme, the brain cancer that killed Sen. Edward Kennedy, is aggressive and incurable. Northwestern University researchers are the first to demonstrate delivery of a drug that turns off a critical gene in this complex cancer, increasing survival rates significantly in animals with the disease. The therapeutic, based on nanotechnology, is nimble enough to cross the blood-brain barrier and get to the brain tumor. Once there, it flips the switch of the oncogene to "off," silencing the gene.
NIH/National Cancer Institute, Defense Advanced Research Projects Agency

Contact: Megan Fellman
Northwestern University

Public Release: 30-Oct-2013
Journal of Biological Chemistry
Old drug may teach new tricks in treating infectious diseases, cancer
Meclizine, an over-the-counter drug used for decades to treat nausea and motion sickness, has the potential for new uses to treat certain infectious diseases and some forms of cancer.

Contact: Kathleen Phillips
Texas A&M AgriLife Communications

Public Release: 30-Oct-2013
International Journal of Molecular Sciences
BUSM researchers study epigenetic mechanisms of tumor metastasis for improved cancer therapy
A review article by researchers at Boston University School of Medicine suggests that epigenetics may be a useful target to stop the growth, spread and relapse of cancer.

Contact: Gina Orlando
Boston University Medical Center

Public Release: 30-Oct-2013
New study analyzes barriers to cancer research commercialization
A new study led by the University of Kentucky Markey Cancer Center Assistant Director for Research Nathan Vanderford cites a combination of factors that prevent academic-based cancer research faculty from ultimately commercializing their work.

Contact: Allison Perry
University of Kentucky

Public Release: 30-Oct-2013
TGen-led research shows ability to do next-generation sequencing for patients with advanced cancers
A pilot study led by the Translational Genomics Research Institute and the Virginia G. Piper Cancer Center at Scottsdale Healthcare shows that, even for patients with advanced and rapidly transforming cancer, researchers can find potential therapeutic targets using the latest advances in genomic sequencing. Sequencing spells out, or decodes, the billions of letters of DNA and other genomic data so that clinicians can discover what genetic changes might lead to cancer.
National Foundation for Cancer Research

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Public Release: 30-Oct-2013
HPV vaccination rates alarmingly low among young adult women in South
Initiation and completion rates for the human papillomavirus vaccine series are significantly lower in the South than any other geographic region, according to a new study from researchers at the University of Texas Medical Branch at Galveston. The new findings are especially disconcerting because cervical cancer -- which is caused almost exclusively by HPV -- is more prevalent in the South than in any other region. Further, although vaccination rates have risen since 2008, the findings underscore the need for increased physician recommendation and vaccine assistance programs.
NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development

Contact: Molly Dannenmaier
University of Texas Medical Branch at Galveston

Public Release: 29-Oct-2013
Annals of Oncology
Teenagers and young adults diagnosed with cancer are at increased risk of suicide
Teenagers and young adults are at increased risk of suicide after being diagnosed with cancer according to a study published in the leading cancer journal Annals of Oncology. A study of nearly eight million Swedes aged 15 and over found that among the 12,669 young people diagnosed with cancer between the age of 15 and 30 there was a 60 percent increased risk of suicide or attempted suicide. The risk was highest (150 percent) in the first year after diagnosis.
Swedish Council for Working Life and Social Research, Swedish Research Council, and others

Contact: Emma Mason
European Society for Medical Oncology

Public Release: 29-Oct-2013
Cancer Prevention Research
Pregnant rats exposed to obesity hormone lose birth's protective effect on breast cancer
Like humans, young rats that give birth have a reduced risk of breast cancer later in life. But a new study shows that this protective effect in animals is negated if they're exposed to an obesity-linked hormone during pregnancy.
NIH/National Cancer Institute

Contact: Karen Mallet
Georgetown University Medical Center

Public Release: 29-Oct-2013
12th annual AACR International Conference on Frontiers in Cancer Prevention Research
Sedentary behavior linked to recurrence of precancerous colorectal tumors
Men who spend the most time engaged in sedentary behaviors are at greatest risk for recurrence of colorectal adenomas, benign tumors that are known precursors of colorectal cancers. Although there is extensive evidence supporting an association between higher overall levels of physical activity and reduced risk of colorectal cancer, few studies have focused on the impact of sedentary behavior on colorectal cancer risk.
NIH/National Cancer Institute

Contact: Stephanie Berger
Columbia University's Mailman School of Public Health

Public Release: 29-Oct-2013
Obesity Research & Clinical Practice
Weight at time of diagnosis linked to prostate cancer mortality
Men who are overweight or obese when they are diagnosed with prostate cancer are more likely to die from the disease than men who are of healthy weight, according to a Kaiser Permanente study published today in the journal Obesity Research & Clinical Practice.
NIH/National Cancer Institute

Contact: Joshua Weisz
Kaiser Permanente

Public Release: 29-Oct-2013
Risk Analysis
News that is better or worse than expected influences health decisions
Patients who are unrealistically optimistic about their personal health risks are more likely to take preventive action when confronted with news that is worse than expected, while unrealistic pessimists are less likely to change their behavior after receiving feedback that is better than expected.

Contact: Bettye Miller
University of California - Riverside

Public Release: 28-Oct-2013
Materials Science and Technology Conference
UC develops unique nano carrier to target drug delivery to cancer cells
University of Cincinnati researchers have developed a unique nanostructure that can, because of its dual-surface structure, serve as an improved "all-in-one tool" against cancer.
National Science Foundation, National Natural Science Foundation of China, Shanghai Nano-program

Contact: M.B. Reilly
University of Cincinnati

Public Release: 28-Oct-2013
Cancer Immunology Research
Researchers discover how cancer 'invisibility cloak' works
Researchers at National Jewish Health have discovered how a lipid secreted by cancer tumors prevents the immune system from mounting an immune response against it. When lysophosphatidic acid binds to killer T cells, it acts almost like an "invisibility cloak," preventing T cells from recognizing and attacking nascent tumors.
National Institutes of Health, Cancer League of Colorado, Cancer Research Institute

Contact: William Allstetter
National Jewish Health

Public Release: 28-Oct-2013
15th World Conference on Lung Cancer
Overlooked lymph nodes in rib cage have prognostic power for mesothelioma patients
For the first time, researchers from the Perelman School of Medicine at the University of Pennsylvania have shown the predictive power of a group of overlooked lymph nodes that could serve as a better tool to stage and ultimately treat patients with malignant pleural mesothelioma.

Contact: Steve Graff
University of Pennsylvania School of Medicine

Public Release: 28-Oct-2013
Researchers detail possible resistance mechanisms of colorectal cancer to bevacizumab (Avastin)
A University of Colorado Cancer Center study published in the journal PLoS One shows that when colorectal cancer is targeted by the drug bevacizumab (Avastin), tumors may switch dependence from VEGF-A, which is targeted by the drug, to related growth factors in including VEGF-C, VEGF-D and placental growth factor. This change to new growth-factor dependence may allow colorectal cancer to push past bevacizumab's blockage of VEGF-A to continue to drive tumor growth.

Contact: Garth Sundem
University of Colorado Denver

Public Release: 28-Oct-2013
Nature Immunology
U of M researchers identify key proteins influencing major immune strategies
New research from the Masonic Cancer Center, University of Minnesota, and the University of Minnesota Center for Immunology has identified key proteins that influence immune response strategies, a finding that could influence new vaccination approaches. The study, published in the latest edition of Nature Immunology, looked closely at the KLF2 and S1P1 genes, and how their expression impacted the immune strategy of a cell.
National Institutes of Health

Contact: Caroline Marin
University of Minnesota Academic Health Center

Public Release: 28-Oct-2013
Renewable Agriculture and Food Systems
Study challenges soil testing for potassium and the fertilizer value of potassium chloride
Three University of Illinois soil scientists have serious concerns with the current approach to potassium management that has been in place for the past five decades because their research has revealed that soil K testing is of no value for predicting soil K availability and that KCl fertilization seldom pays.
University of Illinois

Contact: Debra Levey Larson
University of Illinois College of Agricultural, Consumer and Environmental Sciences

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