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Showing releases 1176-1200 out of 1370.

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Public Release: 5-Feb-2015
Cell Stem Cell
Human stem cells repair damage caused by radiation therapy for brain cancer in rats
For patients with brain cancer, radiation is a potentially life-saving treatment, but it can also cause considerable and even permanent injury to the brain. Now, through preclinical experiments conducted in rats, researchers have developed a method to turn human stem cells into cells that are instructed to repair damage in the brain. As reported in Cell Stem Cell, rats treated with the human cells regained cognitive and motor functions that were lost after brain irradiation.

Contact: Joseph Caputo
Cell Press

Public Release: 5-Feb-2015
Massively parallel sequencing technology for single-cell gene expression published
A new next-generation single-cell approach published in Science by scientists from Cellular Research, Inc. offers a massively parallel way to study gene expression.

Contact: Nicole Litchfield

Public Release: 4-Feb-2015
CA: A Cancer Journal for Clinicians
Lung cancer now leading cause of cancer death in females in developed countries
A new analysis led by researchers at the American Cancer Society in collaboration with the International Agency for Research on Cancer finds lung cancer has surpassed breast cancer as the leading cause of cancer death in females in developed countries.
American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 4-Feb-2015
Science Translational Medicine
Potential pancreatic cancer treatment could increase life expectancy
Pancreatic cancer cells are notorious for being protected by a fortress of tissue, making it difficult to deliver drugs to either shrink the tumor or stop its growth. Now researchers at the University of North Carolina at Chapel Hill have developed a device that could change all that: By using electric fields, the device can drive chemotherapy drugs directly into tumor tissue, preventing their growth and in some cases, shrinking them.
The University Cancer Research Fund, NIH/Pioneer Award, Synecor LLC, and others

Contact: Thania Benios
University of North Carolina at Chapel Hill

Public Release: 4-Feb-2015
ACS Nano
New nanoparticle gene therapy strategy effectively treats deadly brain cancer in rats
New insights into specific gene mutations that arise in glioma, an often deadly form of brain cancer, have pointed to the potential of gene therapy, but it's very difficult to effectively deliver toxic or missing genes to cancer cells in the brain. Now, researchers have used nanoparticles to deliver a new therapy to glioma cells in the brains of rats, prolonging their lives.
NIH/National Institute of Biomedical Imaging and Bioengineering

Contact: Heather Dewar
Johns Hopkins Medicine

Public Release: 4-Feb-2015
Human Molecular Genetics
Major study links 2 new genetic variants to breast cancer
A worldwide study of the DNA of 100,000 women has discovered two new genetic variants associated with an increased risk of breast cancer. The genetic variants are specifically linked to the most common form of breast cancer, estrogen receptor positive, and provide important insights into how the disease develops.

Contact: Claire Hastings
Institute of Cancer Research

Public Release: 4-Feb-2015
European Journal of Cell Biology
Crucial role of breast cancer tumor suppressor revealed
A new study led by José Javier Bravo-Cordero, Spanish researcher at the Albert Einstein College of Medicine in New York, details how cells with low levels of the profilin 1 protein in breast tumors increase their capacity to metastasize and invade other tissues.

Contact: Sinc Agency
FECYT - Spanish Foundation for Science and Technology

Public Release: 4-Feb-2015
Proceedings of the National Academy of Sciences
An extra protein gives naked mole rats more power to stop cancer
A protein newly found in the naked mole rat may help explain its unique ability to ward off cancer. The protein is associated with a locus that is also found in humans and mice. It's the job of that locus to encode several cancer-fighting proteins. As professor of biology Vera Gorbunova explains, the locus found in naked mole rats encodes a total of four cancer-fighting proteins, while the human and mouse version encodes only three.
National Institutes of Health, Life Extension Foundation, Glenn Foundation for Medical Research, Ellison Medical Foundation

Contact: Peter Iglinski
University of Rochester

Public Release: 4-Feb-2015
ACS Applied Materials & Interfaces
Tiny robotic 'hands' could improve cancer diagnostics, drug delivery
Many people imagine robots today as clunky, metal versions of humans, but scientists are forging new territory in the field of 'soft robotics.' One of the latest advances is a flexible, microscopic hand-like gripper. The development could help doctors perform remotely guided surgical procedures or perform biopsies. The materials also could someday deliver therapeutic drugs to hard-to-reach places. The report appears in the journal ACS Applied Materials & Interfaces.

Contact: Michael Bernstein
American Chemical Society

Public Release: 4-Feb-2015
Science Translational Medicine
Electricity delivers therapy to tumors in potentially new treatment, bioengineer says
A team of researchers has devised a new way to target tumors with cancer-fighting drugs, a discovery that may lead to clinical treatments for cancer patients. Called iontophoresis, the technique delivers chemotherapy to select areas.

Contact: Eleanor Nelsen
Virginia Tech

Public Release: 3-Feb-2015
MicroRNAs can limit cancer spread
In cancer patients with limited spread, certain microRNAs suppress tumor cells' ability to adhere to other cell types, invade tissues and migrate to distant sites, the hallmarks of metastasis. This could predict how aggressively a tumor can spread and guide treatment.
Virginia and D.K. Ludwig Fund for Cancer Research, Lung Cancer Foundation, Prostate Cancer Foundation, Foglia Family

Contact: John Easton
University of Chicago Medical Center

Public Release: 3-Feb-2015
British Journal of Cancer
One in 2 people in the UK will get cancer
One in two people will develop cancer at some point in their lives, according to the most accurate forecast to date from Cancer Research UK, and published in the British Journal of Cancer.
Cancer Research UK

Contact: Greg Jones
Cancer Research UK

Public Release: 3-Feb-2015
Genome Biology
Culture shock -- Are lab-grown cells a faithful model for human disease?
Cell cultures used in research may not act as a faithful mimic of real tissue, according to research published in Genome Biology. Laboratory-grown cells experience altered cell states within three days as they adapt to their new environment. Studies of disease, including cancer, rely on cell cultures that have often been grown for decades. The findings could affect the interpretation of past studies and provide important clues for improving cell cultures in the future.

Contact: Joel Winston
BioMed Central

Public Release: 3-Feb-2015
Journal of Clinical Oncology
Smoking linked to higher risk of death among colorectal cancer survivors
Colorectal cancer survivors who smoke cigarettes were at more than twice the risk of death than non-smoking survivors, according to a new American Cancer Society study
American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 3-Feb-2015
Sparing hope for the future: Preserving fertility in cancer patients
While families around the world delay childbearing to later in life, cancer diagnoses are affecting people ever earlier in life. When these lifestyle trends collide, we see an increasing number of young women rendered infertile by cancer or cancer treatments. What can be done about it? What do doctors need to know? And does a cancer diagnosis mean that a patient can never have children?

Contact: Katie Foxall

Public Release: 3-Feb-2015
Heart Failure Winter Research Meeting
New molecule protects heart from toxic breast cancer drugs
A new molecule has been found that protects the heart from toxic breast cancer drugs and also kills the cancerous tumor. The research from Italy addresses the burgeoning problem of heart disease in cancer survivors and is announced by the European Society of Cardiology today on World Cancer Day.

Contact: Céline Colas
European Society of Cardiology

Public Release: 3-Feb-2015
Journal of Immunology
A few cells could prevent bone marrow transplant infections
Researchers find clues for reducing infections after bone marrow transplantation for leukemia and lymphoma.

Contact: Edyta Zielinska
Thomas Jefferson University

Public Release: 3-Feb-2015
Serendipity leads to discovery of adult cancer genes in young-adult Ewing Sarcoma
A University of Colorado Cancer Center study published in the journal PLoS One finds alterations in expression of genes PIK3R3 and PTEN, more commonly observed in adult tumors, in the rare, young-adult bone cancer Ewing Sarcoma, potentially offering ways to improve therapy.

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 3-Feb-2015
Dartmouth researchers reprogram tumor's cells to attack itself
Inserting a specific strain of bacteria into the microenvironment of aggressive ovarian cancer transforms the behavior of tumor cells from suppression to immunostimulation, Dartmouth researchers have found. The findings demonstrate a new approach in immunotherapy that can be applied in a variety of cancer types.
National Institutes of Health, NIH/National Institute of General Medical Sciences

Contact: Kirk Cassels
The Geisel School of Medicine at Dartmouth

Public Release: 3-Feb-2015
Nature Genetics
Study sheds new light on aggressive cancer in children
A new study involving researchers at The University of Nottingham has revealed how children with an aggressive cancer predisposition syndrome experience a never before seen flood of mutations in their disease in just six months.
BRAINchild Canada, Canadian Institutes of Health Research, Wellcome Trust Sanger Institute, SickKids Foundation

Contact: Emma Rayner
University of Nottingham

Public Release: 3-Feb-2015
Stem Cell Reports
Glioblastoma: Study ties 3 genes to radiation resistance in recurrent tumors
A new study identifies three genes that together enable a lethal form of brain cancer to recur and progress after radiation therapy. The findings could lead to new therapies for brain tumors that target cancer stem cells.
American Cancer Society, National Institutes of Health, Danish Cancer Society, Danish National Research Foundation

Contact: Darrell E. Ward
Ohio State University Wexner Medical Center

Public Release: 2-Feb-2015
Moffitt researchers discover biological markers associated with high-risk pancreatic lesions
Pancreatic cancer affects approximately 46,000 people each year in the United States and ranks fourth among the leading causes of cancer-related deaths. Only about 6 percent of individuals with pancreatic cancer will live five years after their diagnosis. One reason for this high mortality rate is the lack of effective tools to detect pancreatic cancer early enough to allow its surgical removal. Moffitt Cancer Center researchers are now one step closer to devising an approach to detect pancreatic cancer earlier.
American Chemical Society, NIH/National Cancer Institute

Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 2-Feb-2015
Journal of Thoracic Disease
Whose numbers determine cost-effectiveness of targeted anti-cancer therapies?
'Increasingly physicians are being presented with health economic analyses in mainstream medical journals as a means of potentially influencing their prescribing. However, it is only when you understand the multiple assumptions behind these calculations that you can see that they are by no means absolute truths,' says D. Ross Camidge, M.D., Ph.D., investigator at the University of Colorado Cancer Center.

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 2-Feb-2015
British Journal of Surgery
Surgical innovations brought to you by the British Journal of Surgery
Special issue of the British Journal of Surgery highlights surgical innovations.

Contact: Dawn Peters

Public Release: 2-Feb-2015
Cell Cycle
Dartmouth researchers discover new mechanism of acquired resistance to breast cancer drugs
In the search for new approaches to treat ERBB2 -- also known as HER2 -- positive breast cancers that have become drug-resistant, Dartmouth investigator Manabu Kurokawa, Ph.D., led a team in discovery of a novel cancer resistance mechanism.
National Institutes of Health

Contact: Kirk Cassels
The Geisel School of Medicine at Dartmouth

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