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Showing releases 1176-1200 out of 1281.

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Public Release: 27-Aug-2015
JAMA Oncology
Researchers develop framework for value-based pricing of cancer drugs
At a time when cancer drug prices are rising rapidly, an innovative new study provides the framework for establishing value-based pricing for all new oncology drugs entering the marketplace.

Contact: Judy Fortin
Emory Health Sciences

Public Release: 27-Aug-2015
Scientists reveal cellular clockwork underlying inflammation
Researchers at the Virginia Bioinformatics Institute at Virginia Tech have uncovered key cellular functions that help regulate inflammation -- a discovery that could have important implications for the treatment of allergies, heart disease, and certain forms of cancer. The discovery, to be published in the Oct. 6 issue of the journal Structure, explains how two particular proteins, Tollip and Tom1, work together to contribute to the turnover of cell-surface receptor proteins that trigger inflammation.

Contact: John Pastor
Virginia Tech

Public Release: 27-Aug-2015
Researchers mimic viral infection in colon cancer stem cells
Researchers targeting colorectal cancer stem cells -- the root cause of disease, resistance to treatment and relapse -- have discovered a mechanism to mimic a virus and potentially trigger an immune response to fight the cancer like an infection.
Cancer Research Society, Stand Up To Cancer (Epigenetics Dream Team), The Princess Margaret Cancer Foundation

Contact: Jane Finlayson
University Health Network

Public Release: 27-Aug-2015
Journal of Molecular Diagnostics
CanDL database shines light on clinically important cancer gene mutations
To help molecular pathologists, laboratory directors, bioinformaticians and oncologists identify key mutations that drive tumor growth in tissues obtained during cancer clinical studies, researchers at the Ohio State University Comprehensive Cancer Center -- James Cancer Hospital and Solove Research Institute have designed an online database called the Cancer Driver Log, or CanDL.
Pelotonia, Prostate Cancer Foundation, American Cancer Society, NIH/National Human Genome Research Institute

Contact: Darrell E. Ward
Ohio State University Wexner Medical Center

Public Release: 26-Aug-2015
3-D cancer models give fresh perspective on progress of disease
Computer models of developing cancers reveal how tiny movements of cells can quickly transform the makeup of an entire tumor.
Leverhulme Trust, The Royal Society of Edinburgh

Contact: Catriona Kelly
University of Edinburgh

Public Release: 26-Aug-2015
Science Translational Medicine
New 'mutation-tracking' blood test could predict breast cancer relapse months in advance
Scientists have developed a blood test for breast cancer able to identify which patients will suffer a relapse after treatment, months before tumors are visible on hospital scans. The test can uncover small numbers of residual cancer cells that have resisted therapy by detecting cancer DNA in the bloodstream.
NIHR Biomedical Research Centre at The Royal Marsden, Institute of Cancer Research, Breast Cancer Now, Cancer Research UK

Contact: Henry French
Institute of Cancer Research

Public Release: 26-Aug-2015
Capturing cancer
Researchers have developed the first model of solid tumors that reflects both their three-dimensional shape and genetic evolution. The new model explains why cancer cells have a surprising number of genetic mutations in common, how driver mutations spread through the whole tumor and how drug resistance evolves.

Contact: Peter Reuell
Harvard University

Public Release: 26-Aug-2015
Survivors of childhood cancer have high-risk of recurrent stroke
A new study from the UCSF Pediatric Brain Center shows that childhood cancer survivors suffering one stroke have double the risk of suffering a second stroke, when compared with non-cancer stroke survivors.

Contact: Lisa Marie Potter
University of California - San Francisco

Public Release: 26-Aug-2015
Science Translational Medicine
Stiffer breast tissue in obese women promotes tumors
Women who are obese have a higher risk and a worse prognosis for breast cancer, but the reasons why remain unclear. A Cornell study published this month in Science Translational Medicine explains how obesity changes the consistency of breast tissue in ways that are similar to tumors, thereby promoting disease.
National Institutes of Health, National Science Foundation, Breast Cancer Research Foundation, Weill Cornell Medical College/Botwinick-Wolfensohn Foundation

Contact: Melissa Osgood
Cornell University

Public Release: 26-Aug-2015
Journal of Nutritional Biochemistry
Colorful potatoes may pack powerful cancer prevention punch
Compounds found in purple potatoes may help kill colon cancer stem cells and limit the spread of the cancer, according to a team of researchers.
US Department of Agriculture

Contact: Matt Swayne
Penn State

Public Release: 26-Aug-2015
Journal of Geriatric Oncology
High use of alternative medicine in senior oncology patients
Many seniors with cancer are also using complementary or alternative medicines that could interfere with their cancer treatment.

Contact: Edyta Zielinska
Thomas Jefferson University

Public Release: 25-Aug-2015
New Moffitt study finds black women have higher frequency of BRCA mutations than previously reported
Moffitt Cancer Center researchers recently conducted the largest US based study of BRCA mutation frequency in young black women diagnosed with breast cancer at or below age 50 and discovered they have a much higher BRCA mutation frequency than that previously reported among young white women with breast cancer.
Florida Biomedical, American Cancer Society, Florida Breast Cancer Foundation, NIH/National Cancer Institute

Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 25-Aug-2015
Relapse, poor survival in leukemia linked to genetic mutations that persist in remission
New research suggests that genome sequencing while a cancer patient is in remission can help physicians assess response to treatment and determine whether aggressive, follow-up treatment is necessary. The study, published Aug. 25 in JAMA, involved patients with acute myeloid leukemia.
National Institutes of Health, The Foundation for Barnes-Jewish Hospital

Contact: Jim Goodwin
Washington University School of Medicine

Public Release: 25-Aug-2015
Genetic mutations may help predict risk of relapse, survival for leukemia patients
In preliminary research, the detection of persistent leukemia-associated genetic mutations in at least 5 percent of bone marrow cells in day 30 remission samples among adult patients with acute myeloid leukemia was associated with an increased risk of relapse and reduced overall survival, according to a study in the Aug. 25 issue of JAMA.

Contact: Diane Duke Williams
The JAMA Network Journals

Public Release: 25-Aug-2015
Nature Communications
Injectable cryogel-based whole-cell cancer vaccines
New research led by Wyss Core Faculty member David Mooney could potentially yield a new platform for cancer vaccines. Leveraging a biologically inspired sponge-like gel called 'cryogel' as an injectable biomaterial, the vaccine delivers patient-specific tumor cells together with immune-stimulating biomolecules to enhance the body's attack against cancer. The approach, a so-called 'injectable cryogel whole-cell cancer vaccine,' is reported online in Nature Communications on Aug. 12.

Contact: Kat McAlpine
Wyss Institute for Biologically Inspired Engineering at Harvard

Public Release: 25-Aug-2015
Batting practice in the genome
In the biochemical game of genetics, it was thought that the proteins controlling gene regulation in animals were either spectators or players. But in research appearing in the current issue of eLife, Michigan State University researchers found that spectator proteins are actually practicing up for the big game.

Contact: Mark Kuykendall
Michigan State University

Public Release: 25-Aug-2015
Environmental Chemistry Letters
Is incense bad for your health?
The burning of incense might need to come with a health warning. This follows the first study evaluating the health risks associated with its indoor use. The effects of incense and cigarette smoke were also compared, and made for some surprising results. The research was led by Rong Zhou of the South China University of Technology and the China Tobacco Guangdong Industrial Company in China, and is published in Springer's journal Environmental Chemistry Letters.

Contact: Joan Robinson

Public Release: 25-Aug-2015
Journal of Biomedical Optics
New optical method promises faster, more accurate diagnosis of breast cancer
A new optical method promising faster, more accurate diagnosis of breast cancer is reported in a new article in the Journal of Biomedical Optics, published by SPIE, the international society for optics and photonics, by researchers at the University of Illinois at Urbana-Champaign and the University of Illinois at Chicago. The researchers used spatial light interference microscopy to obtain quantitative data for tissue analysis, in place of manual inspection.

Contact: Amy Nelson
SPIE--International Society for Optics and Photonics

Public Release: 25-Aug-2015
Longer colonoscopies linked to lower cancer rate
Research by a Veterans Affairs team has confirmed that longer-lasting colonoscopies -- those with a longer 'withdrawal time' -- are associated with lower cancer rates. The findings were based on nearly 77,000 procedures.
US Department of Veterans Affairs

Contact: Ralph Heussner
Veterans Affairs Research Communications

Public Release: 25-Aug-2015
Nature Reviews Cancer
Promising target for new drugs found in pancreatic cancer cells
Pancreatic cancer is extremely deadly and often has a poor prognosis. University of Houston researchers are on a mission to develop drugs that will allow physicians to prolong patient survival and, possibly, even eradicate this deadliest of cancers. Funded by Golfers Against Cancer and the Cancer Prevention and Research Institute of Texas, the results are summarized in Nature Reviews Cancer.
Golfers Against Cancer, Cancer Prevention and Research Institute of Texas

Contact: Lisa Merkl
University of Houston

Public Release: 24-Aug-2015
Human Gene Therapy
Optimizing effectiveness of CAR T cell therapy in lymphoma highlighted in special nordic issue
Chimeric antigen receptor T cells, which can specifically recognize and target tumor cells, have resulted in complete responses in patients with leukemia, and although equally promising for treating lymphoma, obstacles remain and individual patient responses CAR T cell therapy have varied. The main barriers to overcome in developing the next generation of CAR T cell therapy are presented in a Review article that is part of a special Nordic issue of Human Gene Therapy.

Contact: Kathryn Ryan
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 24-Aug-2015
Nature Neuroscience
Promising class of new cancer drugs might cause memory loss in mice
New research shows that a family of cancer drugs currently tested in patient trials can induce neurological changes in mice. The findings underscore the need for more research to determine whether these compounds can enter the brain, where they potentially might cause side effects such as memory loss.

Contact: Eva Kiesler
Rockefeller University

Public Release: 24-Aug-2015
New study provides links between inflammation and colon cancer metastasis
A new Arizona State University research study led by Biodesign Institute executive director Raymond DuBois, M.D., Ph.D., has identified for the first time the details of how inflammation triggers colon cancer cells to spread to other organs, or metastasize.
National Institutes of Health, National Colorectal Cancer Research Alliance

Contact: Joe Caspermeyer
Arizona State University

Public Release: 24-Aug-2015
Proceedings of the National Academy of Sciences
FSU researcher identifies protein with promise for cancer therapy
In the second part of his lab's recent one-two punch, Florida State University researcher Daniel Kaplan said he has solved a cell division mystery in a way that will intrigue the makers of cancer-fighting drugs.

Contact: Ronald Hartung
Florida State University

Public Release: 24-Aug-2015
Veterinary Immunology and Immunopathology
Compound found in red wine causes conflicting changes in dogs' immune systems
Researchers at the University of Missouri have found that resveratrol does affect the immune systems of dogs in different ways when introduced to dogs' blood.

Contact: Nathan Hurst
University of Missouri-Columbia

Showing releases 1176-1200 out of 1281.

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