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Showing releases 1176-1200 out of 1250.

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Public Release: 12-Mar-2014
Nature Structural & Molecular Biology
Protein key to cell motility has implications for stopping cancer metastasis
A Penn team describes how a key cell-movement protein called IRSp53 is regulated in a resting and active state, and what this means for cancer-cell metastasis. They characterized how IRSp53 connects to the cell-motility machinery by starting the formation of cell filopodia.
National Institutes of Health, American Cancer Society

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 12-Mar-2014
Journal of Lipid Research
Breast cancer gene could play critical role in obesity and diabetes
The gene known to be associated with breast cancer susceptibility, BRCA 1, plays a critical role in the normal metabolic function of skeletal muscle, according to a new study led by kinesiology researchers in the University of Maryland School of Public Health. Mutations in the BRCA1 gene may also put people at increased risk for metabolic diseases like obesity and type 2 diabetes.

Contact: Kelly Blake
kellyb@umd.edu
301-405-9418
University of Maryland

Public Release: 12-Mar-2014
JAMA Psychiatry
Nicotine withdrawal weakens brain connections tied to self-control over cigarette cravings
A new brain imaging study in this week's JAMA Psychiatry from scientists in Penn Medicine and the National Institute on Drug Abuse Intramural Research Program shows how smokers suffering from nicotine withdrawal may have more trouble shifting from a key brain network -- known as default mode, when people are in a so-called 'introspective' state -- and into a control network that could help exert more self-control over cravings and to focus on quitting for good.
NIH/National Cancer Institute, NIH/National Institute on Drug Abuse

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine

Public Release: 12-Mar-2014
Journal of Oncology Practice
Transition to ICD-10 may cause information, financial losses for providers
The study, appearing in the March issue of the Journal of Oncology Practice, looked at coding ambiguity for hematology-oncology diagnoses to anticipate challenges all providers may face during the transition from ICD-9-CM to ICD-10-CM.

Contact: Sherri McGinnis Gonzalez
smcginn@uic.edu
312-996-8277
University of Illinois at Chicago

Public Release: 11-Mar-2014
Journal of Clinical Investigation
Study finds CT scans predict chemotherapy response in pancreatic cancer
Computed tomography scans routinely taken to guide the treatment of pancreatic cancer may provide an important secondary benefit. According to new research from the University of Texas MD Anderson Cancer Center, the scans also reflect how well chemotherapy will penetrate the tumor, predicting the effectiveness of treatment.

Contact: William Fitzgerald
wbfitzgerald@mdanderson.org
713-792-9518
University of Texas M. D. Anderson Cancer Center

Public Release: 11-Mar-2014
Anesthesiology
Anesthetic technique improves quality of recovery for women having breast cancer surgery
Anesthesiologists using a technique similar to a dental freeze can improve the quality of recovery and decrease recovery time for breast cancer surgery patients, according to a new study.
Ontario Ministry of Health and Long Term Care/Alternate Funding Plan Innovation Fund

Contact: Geoff Koehler
koehlerg@smh.ca
416-864-6060 x6537
St. Michael's Hospital

Public Release: 11-Mar-2014
British Journal of Cancer
New prognostic test for breast cancer could improve patient treatment
A study by researchers in Nottingham has developed a new clinical test for breast cancer which aims to improve patient treatment.
Medical Research Council

Contact: Emma Thorne
emma.thorne@nottingham.ac.uk
44-011-595-15793
University of Nottingham

Public Release: 11-Mar-2014
PLOS ONE
Researchers slow pancreatic cancer growth by blocking key enzyme
A research team from Imperial College London has shown that blocking the function of an enzyme known as Hhat slows the growth and spread of pancreatic cancer, by preventing a protein called Hedgehog from stimulating nearby normal cells to help the cancer.
Pancreatic Cancer Research Fund

Contact: Becky Tanner
beckytanner@pcrf.org.uk
44-020-836-01119
Pancreatic Cancer Research Fund

Public Release: 11-Mar-2014
Nature Communications
New technique uses ATP as trigger for targeted anti-cancer drug delivery
Biomedical engineering researchers have developed a new technique that uses adenosine-5'-triphosphate, the so-called 'energy molecule,' to trigger the release of anti-cancer drugs directly into cancer cells. Early laboratory tests show it increases the effectiveness of drugs targeting breast cancer.
National Institutes of Health

Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University

Public Release: 11-Mar-2014
Cancer Research
The immune system's redesigned role in fighting cancerous tumors
Researchers in the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute eradicated solid tumors in laboratory mice using a novel combination of two targeted agents. These two synergistic therapies stimulate an immune response, ultimately allowing solid tumors to act as their own cancer-fighting vaccine.

Contact: Cara Martinez
cara.martinez@cshs.org
310-423-7798
Cedars-Sinai Medical Center

Public Release: 11-Mar-2014
Proceedings of the National Academy of Sciences
Cancer cells don't take 'drunken' walks through the body
Biologists have believed that cancers cells spread through the body in a slow, aimless fashion, resembling a drunk who can't walk straight. They now know that's true in a flat petri dish, but not in the three-dimensional space of an actual body.
National Institutes of Health

Contact: Phil Sneiderman
prs@jhu.edu
443-997-9907
Johns Hopkins University

Public Release: 11-Mar-2014
Journal of Pediatric Oncology Nursing
Lack of sleep, stress describe a mother's experience after child's ALL treatment
Many months after their child's diagnosis and treatment, 46 percent of mothers exhibited symptoms of clinical anxiety and 26 percent of mothers showed depressive symptoms.
NIH/National Cancer Institute

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

Public Release: 11-Mar-2014
PLOS ONE
Antibody could be used to target tumor-causing protein, study shows
Cincinnati Cancer Center and University of Cincinnati Cancer Institute researchers have found in a phase-1 study that patients with advanced melanoma and kidney cancer who were treated with a certain antibody that targets a tumor-enhancing protein was safe, which could lead to more treatment options for patients.
Genzyme Corporation, NIH/National Cancer Institute

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center

Public Release: 10-Mar-2014
Cancer Epidemiology, Biomarkers & Prevention
Young skin cancer survivors at risk of other cancers later
Young people who have been diagnosed with non-melanoma skin cancer related to sun exposure, under the age of 25, face a higher risk of developing melanoma and other cancers later in life, a UK study has shown.

Contact: Anne Rahilly
arahilly@unimelb.edu.au
61-390-355-380
University of Melbourne

Public Release: 10-Mar-2014
Journal of Proteome Research
New sugar-test to reduce false-positive cancer diagnoses
The world's most widespread test for ovarian cancer reports false-positives in 94 of 100 diagnosed cases. Now, chemists at the University of Copenhagen have developed a method able to halve the number of false-positives. When fully developed, the new test will spare a significant number of women from unnecessary worry and further testing. Just by including a test on a certain sugar molecule in tandem with the currently prevailing diagnostic test.

Contact: Jes Andersen
jean@science.ku.dk
45-23-60-11-40
University of Copenhagen

Public Release: 10-Mar-2014
Cancer
Targeted drug may prolong survival of patients with cervical cancer
A new clinical study has found that erlotinib, a targeted antitumor agent, has promising potential to improve treatment for cervical cancer. Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the results indicate that larger trials are warranted to determine whether the drug should become part of standard therapy for women with the disease.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
201-748-6358
Wiley

Public Release: 10-Mar-2014
Journal of National Cancer Institute
PSA-testing and early treatment decreases risk of prostate cancer death
Mortality in prostate cancer is lower in areas with frequent use of PSA testing compared with areas with little testing shows a study published online today in Journal of the National Cancer Institute by researchers from Umea University, Sweden and Memorial Sloan Kettering Cancer Center, New York, N.Y., USA.

Contact: Pär Stattin
par.stattin@umu.se
46-736-205-251
Umea University

Public Release: 10-Mar-2014
Proceedings of the National Academy of Sciences
Several FDA-approved anti-cancer drugs induce stem cell tumors, perhaps thwarting therapy
In a surprise finding, University of Massachusetts Amherst and Harvard researchers discovered that several chemotherapeutics that do stop fast growing tumors have the opposite effect on stem cells in the same animal, causing them to divide too rapidly. Not only is the finding of clinical interest, but with this study they successfully used a new non-traditional tool for assessing drugs using stem cells in the fruit fly gut, the first author says.
National Institutes of Health Challenge Grant

Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst

Public Release: 10-Mar-2014
Journal of Clinical Oncology
New prostate cancer treatment convenient, less expensive, but may be riskier
A faster and less expensive form of radiotherapy for treating prostate cancer may come at a price, according to a new study by Yale School of Medicine researchers -- a higher rate of urinary complications.
NIH/National Cancer Institute

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University

Public Release: 10-Mar-2014
BMJ
'Older people denied proper access to cancer care' according to Queen's study
Older people are being denied proper access to cancer care, according to a study by Queen's University Belfast academic, professor Mark Lawler of the Centre for Cancer Research and Cell Biology. Professor Lawler said: 'There is increasing evidence that elderly patients are being 'undertreated,' leading to a 'survival gap' between older and younger patients. Professor Lawler's findings are published in an editorial in the BMJ and titled, 'Ageism In Cancer Care: We Need to Change The Mindset.'

Contact: Anne-Marie Clarke
amclarke2@gmail.com
44-028-909-75320
Queen's University Belfast

Public Release: 10-Mar-2014
Journal of Clinical Investigation
JCI online ahead of print table of contents for March 10, 2014
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers published online, March 10, 2014 in the JCI: 'Identification of a broadly neutralizing HIV-1 antibody in a lupus patient,' 'Evaluating disease-associated protein turnover kinetics,' 'Transport properties of pancreatic cancer describe gemcitabine delivery and response,' 'HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers,' 'iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions,' and more.

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 10-Mar-2014
Nature
UV light aids cancer cells that creep along the outside of blood vessels
A new study by UCLA scientists and colleagues adds further proof to earlier findings by Dr. Claire Lugassy and Dr. Raymond Barnhill of UCLA's Jonsson Comprehensive Cancer Center that deadly melanoma cells can spread through the body by creeping like tiny spiders along the outside of blood vessels without ever entering the bloodstream.

Contact: Shaun Mason
smason@mednet.ucla.edu
310-206-2805
University of California - Los Angeles

Public Release: 10-Mar-2014
Cancer Research
A signal to spread: Wistar scientists identify potent driver of metastasis
An international team of researchers led by scientists at The Wistar Institute have discovered and defined LIMD2, a protein that can drive metastasis, the process where tumors spread throughout the body. Wistar scientists have also developed and patented a monoclonal antibody that may one day be used as a prognostic test to see if tumors have LIMD2, and plans are underway to create inhibitors -- potential drugs that may target cells that produce LIMD2.
National Institutes of Health, Samuel Waxman Cancer Research Foundation, Susan G. Komen, O'Neill Foundation for Melanoma

Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute

Public Release: 10-Mar-2014
New England Journal of Medicine
Moffitt Cancer Center pioneers worldwide standard in diagnosing melanoma
Moffitt Cancer Center researchers have been instrumental in making significant improvements to the diagnostic procedure called sentinel node biopsy for melanoma patients and teaching this procedure to physicians from around the world.
NIH/National Cancer Institute, National Institutes of Health, Australia and New Zealand Melanoma Trials Group

Contact: Kimberly Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 10-Mar-2014
Blood
Study finds pill may represent promising treatment for stubborn blood cancers
A pill that suppresses a key regulator of cancer growth may provide hope to relapsed leukemia and lymphoma patients running out of treatment options for their aggressive, treatment-resistant disease, according to three reports published online today in Blood, the journal of the American Society of Hematology.

Contact: Kaitlin Bressler
kbressler@hematology.org
202-552-4952
American Society of Hematology

Showing releases 1176-1200 out of 1250.

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