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Showing releases 1176-1200 out of 1359.

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Public Release: 28-Jan-2016
Free Radical Biology and Medicine
University of Arizona researchers identify food additive that may prevent skin cancer
Two researchers at the University of Arizona College of Pharmacy have discovered that a compound found in the natural food additive annatto prevents the formation of cancer cells and skin damage from UV radiation in mice. In the future the compound, bixin, may be valuable in the prevention and treatment of human skin cancers.
NIH/National Institute of Environmental Health Sciences, NIH/National Cancer Institute

Contact: Ginny Geib
University of Arizona, College of Pharmacy

Public Release: 28-Jan-2016
JAMA Oncology
Genomics studies assess childhood, young adulthood cancers
Genomics assessments of childhood and young adulthood cancers are the subject of two new studies, an editorial and an author audio interview published online by JAMA Oncology.

Contact: Anne Doerr
The JAMA Network Journals

Public Release: 28-Jan-2016
Cell Reports
Researchers tease apart a pathway certain cancer cells use to replicate
A new 'player' in the way certain aggressive cancer cells may reproduce has been identified. It is hoped that these findings may lead to the identification of new cancer targets and may ultimately lead to new therapeutics.
National Institutes of Health Pathway to Independence Award , Karin Grunebaum Cancer Research Foundation, Peter Paul Professorship, Cancer Research Society/Société de recherche sur le cancer

Contact: Gina DiGravio
Boston University Medical Center

Public Release: 28-Jan-2016
New insights into PI3K pathway and cancer metabolism
New research led by scientists at Beth Israel Deaconess Medical Center (BIDMC) provides important insights into the biology that underlies glycolysis, the metabolic process that enables cancer cells to generate biomass and energy, confirming the importance of sugar to cancer survival.
NIH/National Cancer Institute, National Science Foundation, Stand Up 2 Cancer, Breast Cancer Research Foundation, Mary Kay Ash Foundation, Damon Runyon Cancer Research Foundation

Contact: Bonnie Prescott
Beth Israel Deaconess Medical Center

Public Release: 28-Jan-2016
JAMA Oncology
Genetic sequencing can help guide treatment in children with solid tumors
Clinical genomic sequencing is feasible in pediatric oncology and can be used to recommend therapy or pinpoint diagnosis in children with solid tumors, according to the multi-center Individualized CAncer Therapy (iCat) study led by investigators from Dana-Farber/Boston Children's Cancer and Blood Disorders Center.
Hyundai Hope on Wheels, Friends for Life Foundation, Gillmore Fund

Contact: Anne Doerr
Dana-Farber Cancer Institute

Public Release: 28-Jan-2016
A cancer's surprise origins, caught in action
Researchers at Boston Children's Hospital have, for the first time, visualized the origins of cancer from the first affected cell and watched its spread in a live animal.
National Institutes of Health, NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases, the Ellison Foundation, the Melanoma Research Alliance, the V Foundation and the Howard Hughes Medical Institute

Contact: Keri Stedman
Boston Children's Hospital

Public Release: 28-Jan-2016
TSRI study reveals workings of mysterious 'relief valve' that protects cells from swelling
Solving a long-standing mystery in cell biology, a team has shown how a key 'relief-valve' in cells keeps cells from taking in too much water and swelling excessively. The mechanism has been tentatively linked to stroke-induced brain damage, diabetes, immune deficiency and even cancer treatment resistance.
National Institutes of Health, Howard Hughes Medical Institute

Contact: Madeline McCurry-Schmidt
Scripps Research Institute

Public Release: 28-Jan-2016
Nucleic Acids Research
Toward a better understanding of the mechanisms blocking cancer cell growth
A study published in the journal Nucleic Acids Research provides valuable information about certain mechanisms governing DNA repair and opens the way to better understand the mechanisms of action of drugs that prevent cancer cell growth.
Canadian Institutes of Health Research, Institut Mérieux, Cole Foundation

Contact: Julie Gazaille
University of Montreal

Public Release: 28-Jan-2016
JAMA Oncology
Fertility issues for patients with cancer examined in collection of articles
A collection of articles published online by JAMA Oncology examines fertility issues, both regarding clinical care and legal questions, in patients with cancer.

Contact: Claudia L. Maj
The JAMA Network Journals

Public Release: 28-Jan-2016
Journal of Thoracic Oncology
In lung cancer, not all HER2 alterations are created equal
Study shows two distinct causes of HER2 activation in lung cancer: mutation of the gene and amplification of the gene. In patient samples of lung adenocarcinoma, 3 percent were found to have HER2 amplification and another 3 percent were found to have HER2 mutation. No samples were found to have both. These distinct causes of HER2 positivity imply the use of different targeted therapies to combat these related but possibly distinct diseases.

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 28-Jan-2016
Multi-center study reveals unique subtypes of most common malignant brain cancer
An international collaborative study has revealed detailed new information about diffuse glioma, the most common type of tumor found in some 80 percent of adult brain cancer patients, raising hopes that better understanding of these disease groups may aid improved clinical outcomes.

Contact: Ron Gilmore
University of Texas M. D. Anderson Cancer Center

Public Release: 28-Jan-2016
New molecular profiling for glioma
Cell publishes on its Jan. 28th edition the results of the largest study ever performed on the molecular profiles of gliomas -- that represent 80 percent of tumors of the central nervous system.
São Paulo Research Foundation, Cancer Prevention & Research Institute of Texas, National Institutes of Health

Contact: USP Scientific Outreach Unit
University of Sao Paulo Scientific Outreach Unit

Public Release: 28-Jan-2016
Cell Reports
The CNIO uses the Internet network theory to decipher the first epigenetic communication network
The discovery, published in 'Cell Reports', is the first communication network between the various signals or marks that make up the epigenome, a key component in gene regulation. The scientists employed the algorithms used to analyse the influence and popularity of websites, such as Wikipedia or social networks. The results provide the basis for exploring communication between the components of the cell epigenome, which could be relevant for example in cancer and neurodegenerative diseases.

Contact: Vanessa Pombo
Centro Nacional de Investigaciones Oncológicas (CNIO)

Public Release: 28-Jan-2016
Microtubules, assemble!
Now, researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences have observed how microtubules and motor proteins assemble into macroscopic networks. Their observation provides a better understanding of cytoskeletal self-organization in general, which may in turn lead to better drug design and new materials that can mimic cellular behaviors.
National Science Foundation, National Institutes of Health, Human Frontier Science Program

Contact: Leah Burrows
Harvard John A. Paulson School of Engineering and Applied Sciences

Public Release: 28-Jan-2016
International study describes new glioma subtypes
In an international study conducted in Brazil, researchers have identified new glioma subtypes on the basis of epigenetic profile. The new findings serve to stratify glioma patients more accurately and will contribute to an enhancement of treatment protocols.
São Paulo Research Foundation

Contact: Samuel Antenor
Fundação de Amparo à Pesquisa do Estado de São Paulo

Public Release: 28-Jan-2016
JAMA Oncology
Genetic testing for childhood cancer patients can identify cause and treatment potential
Combined whole exome tumor and blood sequencing in pediatric cancer patients revealed mutations that could help explain the cause of cancer or have the potential to impact clinical cancer care in 40 percent of patients in a study led by researchers from Baylor College of Medicine and Texas Children's Cancer Center.
NIH/National Cancer Institute, NIH/National Human Genome Research Institute

Contact: Dana Benson
Baylor College of Medicine

Public Release: 28-Jan-2016
New way to identify brain tumor aggressiveness
A comprehensive analysis of the molecular characteristics of gliomas -- the most common malignant brain tumor -- explains why some patients diagnosed with slow-growing (low-grade) tumors quickly succumb to the disease while others with more aggressive (high-grade) tumors survive for many years.
National Institutes of Health

Contact: Karin Eskenazi
Columbia University Medical Center

Public Release: 27-Jan-2016
Journal of the American College of Surgeons
Recommendation to omit radiation therapy after lumpectomy is not frequently implemented
Nearly two-thirds of US women age 70 or older with stage I breast cancer who undergo lumpectomy and are eligible to safely omit subsequent radiation therapy according to national cancer guidelines still receive this treatment, according to new study results.
LSU Health Sciences Center Charles Knight Sr. Endowed Professorship

Contact: Devin Rose
American College of Surgeons

Public Release: 27-Jan-2016
Experts: High drug price trend has 'infected' generics
An article published online today in Blood, the Journal of the American Society of Hematology, suggests that pharmaceutical companies use several strategies to keep affordable generic drugs from the market, illustrating an emerging trend that authors say is becoming as harmful to consumers as high-cost brand-name drugs.

Contact: Amanda Szabo
American Society of Hematology

Public Release: 27-Jan-2016
Fred Hutch endorses HPV vaccination for cancer prevention
In response to low national vaccination rates for the human papillomavirus, or HPV, Fred Hutchinson Cancer Research Center has joined with the 68 other US National Cancer Institute-designated cancer centers in issuing a statement urging for increased vaccination in adolescent girls and boys for the prevention of many types of HPV-related cancers in adulthood.

Contact: Kristen Woodward
Fred Hutchinson Cancer Research Center

Public Release: 27-Jan-2016
UPMC-developed test rapidly, accurately profiles genetics and treatment of brain tumors
Brain tumors can be rapidly and accurately profiled with a next-generation, gene-sequencing test developed at UPMC and the University of Pittsburgh School of Medicine. The test, called GlioSeq, is now being used by UPMC oncologists to help guide treatment planning of brain cancers.
National Institutes of Health

Contact: Anita Srikameswaran
University of Pittsburgh Schools of the Health Sciences

Public Release: 27-Jan-2016
Researchers mine the epigenome to identify likely origins of childhood brain tumor subtype
An international research team led by a St. Jude Children's Research Hospital scientist mined the epigenome to discover the likely cell of origin for Group 4 medulloblastoma, a key step in developing targeted therapies
German Cancer Aid, German Federal Ministry of Education and Research, German Cancer Research Center - Heidelberg Center for Personalized Oncology, CancerSys grant MYC-NET, Human Frontiers Science Program, US Department of Defense

Contact: Frannie Marmorstein
St. Jude Children's Research Hospital

Public Release: 27-Jan-2016
Science of the Total Environment
Drugs and other contaminants found in private drinking wells on Cape Cod
In a new study, researchers found more than a dozen household chemicals in drinking water from private wells on Cape Cod. Backyard septic systems were identified as the likely source of contamination. Given that 44 million Americans rely on private wells and 25 percent of all American households have a septic system, the findings add to growing health concerns about unregulated chemicals in drinking water.

Contact: Alexandra Goho
617-332-4288 x232
Silent Spring Institute

Public Release: 27-Jan-2016
Cancer Chemotherapy and Pharmacology
Basic research led to first FDA-approved immunotherapy for pediatric cancer
Researchers at Children's Hospital Los Angeles have shown that an immunotherapy that until now has only been available to patients enrolled in research studies, is equivalent to the product that has been manufactured for commercial use and can be made available to all patients. The data, published in the journal Cancer Chemotherapy and Pharmacology on Jan. 20, was pivotal to the FDA approval of the first immunotherapy for the treatment of a pediatric cancer.

Contact: Ellin Kavanagh
Children's Hospital Los Angeles

Public Release: 27-Jan-2016
Journal of Nuclear Medicine
A better way to image metastatic prostate cancer
A recent study, reported in the January issue of "The Journal of Nuclear Medicine," shows in a prospective, systematic manner that a PET/CT scan, using the radiotracer F-18-DCFBC to target prostate-specific membrane antigen (PSMA), is significantly more effective at detecting metastatic prostate cancer than conventional imaging methods.
Prostate Cancer Foundation--Young Investigator Award, RSNA Research & Education Foundation--Research Scholar Award

Contact: Laurie Callahan
Society of Nuclear Medicine

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