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Showing releases 1176-1200 out of 1230.

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Public Release: 3-Nov-2013
Life, but not as we know it
A rudimentary form of life that is found in some of the harshest environments on earth is able to sidestep normal replication processes and reproduce by the back door, researchers at The University of Nottingham have found.
Biotechnology and Biological Sciences Research Council

Contact: Emma Thorne
University of Nottingham

Public Release: 3-Nov-2013
Nature Genetics
Singapore scientists expose molecular secrets of bile duct cancers from different countries
A Singapore-led scientific team discovers critical genes in bile duct cancers from different parts of the world. New molecular insights point to potentially different treatment regimens for the same cancer type depending on underlying genetic alterations.

Contact: Rachel Tan

Public Release: 3-Nov-2013
Nature Biotechnology
Is DNA from mom or dad?
A new technique successfully takes on a longstanding challenge in DNA sequencing -- determining whether a particular genetic sequence comes from an individual's mother or father. The method, described in a Ludwig Cancer Research study in Nature Biotechnology, promises to accelerate studies of how genes contribute to disease, improve the process of matching donors with organs and help scientists better understand human migration patterns.
The Ludwig Institute for Cancer Research, Roadmap Epigenome Project

Contact: Rachel Steinhardt
Ludwig Institute for Cancer Research

Public Release: 1-Nov-2013
Journal of Clinical Investigation
JCI early table of contents for Nov. 1, 2013
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Nov. 1, 2013 in the JCI: "Liver tropism is key for B cell deletion immunotherapy," "Dysfunctional chemokine receptor promotes candidiasis," "Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction," "Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis," "Apelin is a positive regulator of ACE2 in failing hearts," and more.
National Institutes of Health, Fonds de la Recherche du Québec-Santé, Knights Templar Eye Foundation, Children's Discovery Institute

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 1-Nov-2013
Journal of Clinical Investigation
Liver tropism is key for B cell deletion immunotherapy
In this issue of the Journal of Clinical Investigation, Philippe Bousse and colleagues at the Pasteur Institute in Paris described the fate of B cells in live mice after treatment with anti-CD20 antibodies.
Institut Pasteur, INSERM, Fondation pour la Recherche Médicale, European Research Council

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 1-Nov-2013
Osteoporosis International
New IOF review provides guidance on fracture prevention in cancer-associated bone disease
A new paper published by an International Osteoporosis Foundation Committee of Scientific Advisors Working Group reviews the epidemiology and pathophysiology of cancer-associated bone disease and provides information about fracture prevention in cancer patients. The review summarizes the pertinent recommendations of leading societies, providing guidance for clinical decision making and information on evidence-based pathways to prevent skeletal-related events and bone loss.

Contact: L. Misteli
International Osteoporosis Foundation

Public Release: 1-Nov-2013
Clinical Cancer Research
Double-pronged attack could treat common children's cancer
A dual-pronged strategy using two experimental cancer drugs together could successfully treat a childhood cancer by inhibiting tumor growth and blocking off the escape routes it uses to become resistant to treatment, finds a new study.

Contact: Lauren King
Institute of Cancer Research

Public Release: 31-Oct-2013
Current Biology
Cellular tail length tells disease tale
Simon Fraser University molecular biologist Lynne Quarmby's adventures in pond scum have led her and four student researchers to discover a mutation that can make cilia, the microscopic antennae on our cells, grow too long. When the antennae aren't the right size, the signals captured by them get misinterpreted. The result can be fatal. They have discovered that the regulatory gene CNK2 is present in cilia and controls the length of these hair-like projections.

Contact: Carol Thorbes
Simon Fraser University

Public Release: 31-Oct-2013
Journal of Clinical Investigation
Newly identified proteins make promising targets for blocking graft-vs.-host disease
Researchers from the University of Michigan Comprehensive Cancer Center have identified new proteins that control the function of critical immune cell subsets called T-cells, which are responsible for a serious and often deadly side effect of lifesaving bone marrow transplants.
National Institutes of Health, Leukemia Lymphoma Society, American Society of Transplantation

Contact: Nicole Fawcett
University of Michigan Health System

Public Release: 31-Oct-2013
Study offers new theory of cancer development
Researchers have devised a way to understand patterns of aneuploidy -- an abnormal number of chromosomes -- in tumors and predict which genes in the affected chromosomes are likely to be cancer suppressors or promoters. They propose that aneuploidy is a driver of cancer rather than a result of it.
US Department of Defense, National Institutes of Health, Howard Hughes Medical Institute

Contact: David Cameron
Harvard Medical School

Public Release: 31-Oct-2013
International Journal of Radiation Oncology • Biology • Physics
Largest ever study of male breast cancer treatment shows more mastectomy, less radiation than in female disease
University of Colorado Cancer Center researchers used data from 4,276 cases of male breast cancer and 718,587 cases of female breast cancer to show that the disease is treated differently in men than in women. Specifically, male breast cancer is treated with mastectomy more often than female breast cancer, and in cases in which locally advanced female breast cancer is commonly treated with radiation, the treatment is less used in the male disease.

Contact: Garth Sundem
University of Colorado Denver

Public Release: 31-Oct-2013
15th World Conference on Lung Cancer
CTCA doctor presents studies at World Conference on Lung Cancer in Australia
Glen J. Weiss, M.D., Director of Clinical Research, Cancer Treatment Centers of America® is presenting two key studies, including one today at the International Association for the Study of Lung Cancer's 15th World Conference on Lung Cancer being held in Sydney, Australia.

Contact: Jennifer Vogel
Cancer Treatment Centers of America

Public Release: 31-Oct-2013
15th World Conference on Lung Cancer
Experimental drug shows encouraging results in treating most common form of lung cancer
MK-3475, an anti-PD1 immunotherapy drug with promising results in advanced trials in melanoma is also showing potential in lung cancer based on preliminary phase 1b data presented at the 15th World Conference on Lung Cancer in Sydney, Australia. By blocking the PD-1 protein, the drug alerts the immune system to attack the cancer. It is generally well tolerated and further trials in lung cancer are currently underway.

Contact: Shaun Mason
University of California - Los Angeles

Public Release: 30-Oct-2013
Cancer Prevention Research
MUHC researchers identify biomarkers that could lead to early diagnosis of colorectal cancer
Diagnosing colorectal cancer is complex; it relies on significant invasive tests and subjective evaluations. This process may soon become much easier thanks to a medical breakthrough by the Research Institute of the McGill University Health Centre. The researchers have identified genetic changes in the colon lining, or mucosa, in colorectal cancer patients that could be used as biomarkers of the disease. That will allow doctors to diagnose patients earlier, more accurately and less invasively.
Canadian Institutes of Health Research

Contact: Julie Robert
514-934-1934 x71381
McGill University Health Centre

Public Release: 30-Oct-2013
Scientists call for action to tackle 'alarmingly' low survival of Kenyan women with cervical cancer
Less than 7 percent of cervical cancer patients in Kenya are getting the optimum treatment needed to eradicate the disease, leading to unnecessary deaths -- a study by The University of Manchester scientists reveals. Results from the research, which looked retrospectively at the treatment of women diagnosed with cervical cancer during a two year period, showed 18 percent of cervical cancer patients in the East African country died within two years of a diagnosis.

Contact: Alison Barbuti
University of Manchester

Public Release: 30-Oct-2013
New England Journal of Medicine
NEJM study evaluates early stem cell transplants for non-Hodgkin's lymphoma
Performing early stem cell transplants in patients with aggressive non-Hodgkin's lymphoma does not improve overall survival in high-risk patients, according to a study published in the New England Journal of Medicine. But early transplantation does appear to be beneficial among a small group of patients who are at the very highest risk, the study found.
NIH/National Cancer Institute

Contact: Jim Ritter
Loyola University Health System

Public Release: 30-Oct-2013
Journal of Cancer Survivorship
Qigong can help fight fatigue in prostate cancer survivors
Flowing movements and meditative exercises of the mind-body activity Qigong may help survivors of prostate cancer to combat fatigue. These are the findings of a study by Dr. Anita Y. Kinney at the University of New Mexico Cancer Center and Dr. Rebecca Campo at the University of North Carolina at Chapel Hill. The study took place at the Huntsman Cancer Institute at the University of Utah, and was published in Springer's Journal of Cancer Survivorship.
NIH/National Center for Complementary and Alternative Medicine, University of Utah/Center on Aging Pilot Award

Contact: Joan Robinson

Public Release: 30-Oct-2013
Science Translational Medicine
Incurable brain cancer gene is silenced
Glioblastoma multiforme, the brain cancer that killed Sen. Edward Kennedy, is aggressive and incurable. Northwestern University researchers are the first to demonstrate delivery of a drug that turns off a critical gene in this complex cancer, increasing survival rates significantly in animals with the disease. The therapeutic, based on nanotechnology, is nimble enough to cross the blood-brain barrier and get to the brain tumor. Once there, it flips the switch of the oncogene to "off," silencing the gene.
NIH/National Cancer Institute, Defense Advanced Research Projects Agency

Contact: Megan Fellman
Northwestern University

Public Release: 30-Oct-2013
International Journal of Molecular Sciences
BUSM researchers study epigenetic mechanisms of tumor metastasis for improved cancer therapy
A review article by researchers at Boston University School of Medicine suggests that epigenetics may be a useful target to stop the growth, spread and relapse of cancer.

Contact: Gina Orlando
Boston University Medical Center

Public Release: 30-Oct-2013
Journal of Biological Chemistry
Old drug may teach new tricks in treating infectious diseases, cancer
Meclizine, an over-the-counter drug used for decades to treat nausea and motion sickness, has the potential for new uses to treat certain infectious diseases and some forms of cancer.

Contact: Kathleen Phillips
Texas A&M AgriLife Communications

Public Release: 30-Oct-2013
HPV vaccination rates alarmingly low among young adult women in South
Initiation and completion rates for the human papillomavirus vaccine series are significantly lower in the South than any other geographic region, according to a new study from researchers at the University of Texas Medical Branch at Galveston. The new findings are especially disconcerting because cervical cancer -- which is caused almost exclusively by HPV -- is more prevalent in the South than in any other region. Further, although vaccination rates have risen since 2008, the findings underscore the need for increased physician recommendation and vaccine assistance programs.
NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development

Contact: Molly Dannenmaier
University of Texas Medical Branch at Galveston

Public Release: 30-Oct-2013
New study analyzes barriers to cancer research commercialization
A new study led by the University of Kentucky Markey Cancer Center Assistant Director for Research Nathan Vanderford cites a combination of factors that prevent academic-based cancer research faculty from ultimately commercializing their work.

Contact: Allison Perry
University of Kentucky

Public Release: 30-Oct-2013
TGen-led research shows ability to do next-generation sequencing for patients with advanced cancers
A pilot study led by the Translational Genomics Research Institute and the Virginia G. Piper Cancer Center at Scottsdale Healthcare shows that, even for patients with advanced and rapidly transforming cancer, researchers can find potential therapeutic targets using the latest advances in genomic sequencing. Sequencing spells out, or decodes, the billions of letters of DNA and other genomic data so that clinicians can discover what genetic changes might lead to cancer.
National Foundation for Cancer Research

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Public Release: 29-Oct-2013
Obesity Research & Clinical Practice
Weight at time of diagnosis linked to prostate cancer mortality
Men who are overweight or obese when they are diagnosed with prostate cancer are more likely to die from the disease than men who are of healthy weight, according to a Kaiser Permanente study published today in the journal Obesity Research & Clinical Practice.
NIH/National Cancer Institute

Contact: Joshua Weisz
Kaiser Permanente

Public Release: 29-Oct-2013
Risk Analysis
News that is better or worse than expected influences health decisions
Patients who are unrealistically optimistic about their personal health risks are more likely to take preventive action when confronted with news that is worse than expected, while unrealistic pessimists are less likely to change their behavior after receiving feedback that is better than expected.

Contact: Bettye Miller
University of California - Riverside

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