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Showing releases 1176-1200 out of 1369.

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Public Release: 21-Mar-2016
Annals of Internal Medicine
Pathologists often disagree on breast biopsy results when diagnosing DCIS
A study applying B-Path (Breast Pathology) Study results to patient populations found that pathologists disagree with one another about 8 percent of the time when diagnosing a single breast biopsy slide. Discordance was more likely in cases of DCIS or atypia, with a tendency toward overdiagnosing disease. The findings are published in Annals of Internal Medicine.

Contact: Cara Graeff
American College of Physicians

Public Release: 18-Mar-2016
American Journal of Pathology
New gene identified as cause, early indicator of breast cancer
When mutated, a gene known for its ability to repair DNA, appears to instead cause breast cancer, scientists report.

Contact: Toni Baker
Medical College of Georgia at Augusta University

Public Release: 18-Mar-2016
Pan Pacific Symposium on Stem Cells and Cancer Research
Cell Transplantation
Cell Transplantation research presented at Eighth Annual PPSSC Conference
Studies published in the May 2016 issue of Cell Transplantation (25(5)) were presented at the 8th Annual Meeting of the Pan Pacific Symposium on Stem Cells and Cancer Research, held in in Hsinchu, Taiwan from April 11-13 of 2015. Researchers presented papers on targeting stem cells, clinical trials and translation, emerging drug targets in development and discovery, cutting edge research in stem cell and immune modulation, and adipose-derived stem cell plasticity for regenerative medicine.

Contact: Robert Miranda
Cell Transplantation Center of Excellence for Aging and Brain Repair

Public Release: 18-Mar-2016
American Journal of Pathology
New effects of ketamine abuse uncovered
Research conducted by scientists at the University of York has revealed how recreational ketamine abuse damages the bladder.
Wellcome Trust

Contact: Saskia Angenent
University of York

Public Release: 18-Mar-2016
Scientific Reports
Stanford scientists develop new technique for imaging cells and tissues under the skin
A team of Stanford Bio-X scientists developed the first technique for viewing cells and tissues in three dimensions under the skin. The work could improve diagnosis and treatment for some forms of cancer and blindness.
US Air Force, NIH/Directors Office, National Science Foundation, Damon Runyon Cancer Research Foundation, Susan G. Komen Breast Cancer Foundation, Mary Kay Foundation, Donald E. and Delia B. Baxter Foundation

Contact: Amy Adams
Stanford University

Public Release: 18-Mar-2016
United States & Canadian Academy of Pathology Annual Meeting
Moffitt pathologists identify new potential target in ovarian serous cancer
Moffitt Cancer Center researchers discovered that patients with ovarian serous cancer and an overexpression of the HER4 protein are less likely to respond to chemotherapy and have a lower rate of survival. That's according to a study Carolina Strosberg, M.D., is presenting this week at the 2016 United States and Canadian Academy of Pathology (USCAP) Annual Conference in Seattle, Washington.

Contact: Lisa Chillura
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 17-Mar-2016
JCI Insight
A molecular subtype of bladder cancer resembles breast cancer
In this month's issue of JCI Insight, a research team characterized a new subtype of muscle-invasive bladder cancer that shares molecular signatures with some forms of breast cancer.
Bladder Cancer Advocacy Network, James Family Foundation and a Partner Fund Management Bladder Cancer Research Innovation Award, University Cancer Research Fund, UNC Oncology Clinical Translational Research Training Program

Contact: Corinne Williams
JCI Journals

Public Release: 17-Mar-2016
Biology of Blood and Marrow Transplantation
VCU scientists develop computer models simulating stem cell transplant recovery
Scientists at Virginia Commonwealth University have developed computer models that can simulate the recovery of the immune system in patients undergoing stem cell transplants.
Genzyme, VCU Massey Cancer Center, Commonwealth Health Research Board, NIH/National Cancer Institute

Contact: John Wallace
Virginia Commonwealth University

Public Release: 17-Mar-2016
For first time, scientists use CRISPR-Cas9 to target RNA in live cells
Scientists have long sought an efficient method for targeting RNA -- intermediary genetic material that carries the genetic code from the cell's nucleus to protein-making machinery -- in living cells. Researchers at University of California, San Diego School of Medicine have now achieved this by applying the popular DNA-editing technique CRISPR-Cas9 to RNA. The study is published March 17, 2016 in Cell.
National Institutes of Health, California Institute for Regenerative Medicine, Howard Hughes Medical Institute, National Health and Medical Research Council of Australia, National Science Foundation Graduate Research Fellowship, Alfred P. Sloan Research

Contact: Heather Buschman
University of California - San Diego

Public Release: 17-Mar-2016
Stem Cell Reports
Reprogramming bone tumors
There exist several oncogenes that drive cancer. In many cases, however, the oncogenes themselves are not sufficient and must be complemented with other mutations before cancer develops. Researchers at the Center for iPS Cell Research and Application, Kyoto University, use cell reprogramming technology to revert cancer cells to a stem cell state. The researchers show that dysfunctional differentiation in conjunction with a specific oncogene could explain the cause of certain bone cancers.
P-DIRECT, Ministry of Education, Culture, Sports, Science, and Technology of Japan, Ministry of Health, Labor, and Welfare of Japan, SICORP, Takeda Science Foundation and Naito Foundation

Contact: Peter Karagiannis
Center for iPS Cell Research and Application - Kyoto University

Public Release: 17-Mar-2016
JCI Insight
Identification of a novel tyrosine kinase inhibitor for acute myeloid leukemia
A new study in JCI Insight reports the development of a new drug that targets both resistant tumors and FLT3-independent acute myeloid leukemia.
National Institutes of Health, Leukemia and Lymphoma Society Translation Research Program, University of North Carolina Cancer Research Fund, National Cancer Institute's Experimental Therapeutics (NExT) program, L'Institut Servier

Contact: Corinne Williams
JCI Journals

Public Release: 17-Mar-2016
JAMA Oncology
New MD Anderson-developed breast cancer staging system emphasizes importance of tumor biology as prognostic indicator
A new breast cancer staging system developed by researchers at The University of Texas MD Anderson Cancer Center finds that incorporating tumor biology is a critical prognostic indicator for women who undergo neoadjuvant, or pre-surgical, therapy for breast cancer.

Contact: Clayton R. Boldt
University of Texas M. D. Anderson Cancer Center

Public Release: 17-Mar-2016
ACS Central Science
Stanford chemists develop an ultra-sensitive test for cancers, HIV
Catching a disease in its earliest stages can lead to more effective therapies. Stanford chemists have increased the likelihood of detecting these diseases via a test that is thousands of times more sensitive than current diagnostics.

Contact: Bjorn Carey
Stanford University

Public Release: 17-Mar-2016
Cancer Research
Moffitt: Neutralizing tumor acidic environment improves immune-targeting therapies
Cancer cells have the ability to grow in an acidic tumor environment that is detrimental to other cells, including immune cells. In a Cancer Research cover article published this week, Moffitt Cancer Center reported that neutralizing the acidic tumor environment increases the efficacy of several immune-targeting cancer therapies.

Contact: Steve Blanchard
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 17-Mar-2016
Scientific Reports
BU researchers discover how RNA editing may promote tumor growth
A new study provides insight on the potential role played by RNA (ribonucleic acid) editing in cancer. The findings, which appear online in the journal Scientific Reports, may further our understanding of an emerging mechanism implicated in tumor initiation and progression, and may thus lead to the development of better treatment options in the future.
MGHPCC Seed Fund program, Evans Center for Interdisciplinary Biomedical Research ARC on 'Etiology and Pathogenesis of Oral Cancer (EPOC)', NIH/National Heart Lung and Blood Institute

Contact: Gina DiGravio
Boston University Medical Center

Public Release: 17-Mar-2016
Emerging Infectious Diseases
TGen helps track down deadly bloodstream infection
The Translational Genomics Research Institute (TGen), working with international investigators, have discovered the source of a potential deadly blood infection in more than 50 South American cancer patients. All of the patients infected with S. Kiliense received ondansetron from the same source, a pharmaceutical company in Columbia.

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Public Release: 17-Mar-2016
Developmental Cell
New cytoplasmic role for proteins linked to neurological diseases, cancers
Researchers at UT Southwestern Medical Center have identified a second role for a class of RNA-binding proteins, revealing new insights about neurological diseases and conditions associated with this protein such as autism, epilepsy, and certain types of cancer.
National Institutes of Health

Contact: Cathy Frisinger
UT Southwestern Medical Center

Public Release: 17-Mar-2016
Journal of American College of Surgeons
Cancer burden can be alleviated by training foreign medical graduates in surgical oncology
Many low- and middle-income countries do not have a defined medical specialty in surgical oncology and lack an educational infrastructure to respond to the local burden of cancer, but a Memorial Sloan Kettering Cancer Center fellowship is succeeding in addressing this problem by training foreign medical graduates in surgical oncology.
NIH/National Cancer Institute Cancer Center Support Grant

Contact: Dan Hamilton
American College of Surgeons

Public Release: 16-Mar-2016
Cancer Discovery
Why some tumors withstand treatment
MIT researchers uncover a mechanism that allows cancer cells to evade targeted therapies.

Contact: Sarah McDonnell
Massachusetts Institute of Technology

Public Release: 16-Mar-2016
AACR Annual Meeting 2016
10-minute urine test can measure specific compounds from food consumed
Can we say goodbye to unreliable food diaries and diet recall in exchange for a urine test that will better aid researchers in figuring out what foods might help prevent cancer? Researchers have developed a method that can quickly evaluate specific food compounds in human urine. They say their method could one day replace unreliable food logs used in population studies examining the effects of diet on cancer and will also help scientists accurately identify the most beneficial anticancer foods.

Contact: Karen Teber
Georgetown University Medical Center

Public Release: 16-Mar-2016
Chinese scientists modulate cholesterol metabolism to potentiate T-cell antitumor immunity
As key players in the immune system, T cells provide tumor surveillance and have direct antitumor effects. In their new study, Prof. XU Chenqi's group and Prof. LI Boliang's group with the Institute of Biochemistry and Cell Biology of the Shanghai Institutes for Biological Sciences, found that inhibiting cholesterol esterification can potentiate the antitumor activity of CD8+ T cells (also known as killer T cells).
National Natural Science Foundation of China, Ministry of Science and Technology of China, Chinese Academy of Sciences/Strategic Priority Research Program, and Science and Technology Commission of Shanghai

Contact: XU Chenqi
Chinese Academy of Sciences Headquarters

Public Release: 16-Mar-2016
Journal of the American College of Cardiology
High coronary calcium score may signal increased risk of cancer, kidney and lung disease
A 10-year follow-up study of more than 6,000 people who underwent heart CT scans suggests that a high coronary artery calcium score puts people at greater risk not only for heart and vascular disease but also for cancer, chronic kidney disease and chronic obstructive pulmonary disease (COPD).
NIH/National Heart, Lung, and Blood Institute, National Center for Research Resources

Contact: Vanessa McMains
Johns Hopkins Medicine

Public Release: 16-Mar-2016
International Journal of Radiation Oncology, Biology, Physics
Higher volume radiation facilities associated with better survival rates
In a new study led by researchers at Brigham and Women's Hospital, investigators looked at men with aggressive prostate cancer who were treated with radiation as well as the case volume of the facility at which they were treated. They found that receiving radiation at a facility that treats a high volume of prostate cancer patients with radiation was associated with improved overall survival.
Prostate Cancer Foundation, Fitz's Cancer Warriors, David and Cynthia Chapin, Scott Forbes and Gina Ventre Fund, and others

Contact: Lori Schroth
Brigham and Women's Hospital

Public Release: 16-Mar-2016
Journal of Thoracic Oncology
Trained technicians using CV software improved the accuracy and quality of LDCT scans
Trained technician screeners with assisted computer-aided nodule detection or computer vision screening workstations can efficiently and accurately review and triage abnormal low-dose computed topography scans for radiologist review.

Contact: Jeff Wolf
International Association for the Study of Lung Cancer

Public Release: 16-Mar-2016
Nature Communications
Antibody developed at Johns Hopkins slows tumor growth and metastasis in mice
Johns Hopkins scientists report they have developed an antibody against a specific cellular gateway that suppresses lung tumor cell growth and breast cancer metastasis in transplanted tumor experiments in mice, according to a new study published in the February issue of Nature Communications.
National Institutes of Health, Veterans Administration Merit Award

Contact: Vanessa Wasta
Johns Hopkins Medicine

Showing releases 1176-1200 out of 1369.

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