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Public Release: 5-Jun-2014
Cell Reports
Our own treacherous immune genes can cause cancer after viral infection
Mutations that cause cancer following HPV, human papillomavirus, infection are caused by a family of genes that normally protect against viral infections, finds new UCL research. This raises the possibility of developing drugs that block the activity of these genes to prevent HPV-associated cancers from developing and reduce the ability of existing cancers to evolve resistance to treatments.
Rosetrees Trust, Debbie Fund, Cancer Research UK

Contact: Harry Dayantis
University College London

Public Release: 5-Jun-2014
JAMA Otolaryngology--Head & Neck Surgery
Study finds public awareness of head and neck cancers low
Public awareness of head and neck cancer is low, with few Americans knowing much about risk factors such as tobacco use and human papillomavirus.

Contact: Helen Dodson
The JAMA Network Journals

Public Release: 5-Jun-2014
Research helps clarify how obesity leads to type 2 diabetes, cancer
In a study published online June 5 in the journal Cell, a researcher at The University of Texas at Dallas and colleagues at the University of California, San Diego found that a protein called HIF-1 alpha plays a key role in the development of insulin resistance and type 2 diabetes in obese mice. The findings may also shed light on the connection between obesity and cancer.
National Institutes of Health, American Diabetes Association

Contact: Amanda Siegfried
University of Texas at Dallas

Public Release: 5-Jun-2014
MAD: Scientists shed light on braking mechanisms in cellular signaling
A team of researchers studying a flowering plant has zeroed in on the way cells manage external signals about prevailing conditions, a capability that is essential for cells to survive in a fluctuating environment.

Contact: Zhiyong Wang
Carnegie Institution

Public Release: 5-Jun-2014
Cell Stem Cell
Fasting may help protect against immune-related effects of chemotherapy and aging
Chemotherapy can cause many side effects, including the depletion of immune cells. Even in the absence of chemotherapy, normal aging takes a heavy toll on the immune system. Now researchers have found that a simple dietary intervention -- periodic fasting -- may combat both chemotherapy-induced and aging-related changes in immune cell function by replenishing stem cells in the blood. The findings suggest that fasting may provide benefits for cancer patients, the elderly, and people with immune defects.

Contact: Mary Beth O'Leary
Cell Press

Public Release: 5-Jun-2014
Cell Stem Cell
Fasting triggers stem cell regeneration of damaged, old immune system
In the first evidence of a natural intervention triggering stem cell-based regeneration of an organ or system, a study in the June 5 issue of the Cell Press journal Cell Stem Cell shows that cycles of prolonged fasting not only protect against immune system damage -- a major side effect of chemotherapy -- but also induce immune system regeneration, shifting stem cells from a dormant state to a state of self-renewal.
NIH/National Institute on Aging

Contact: Suzanne Wu
University of Southern California

Public Release: 5-Jun-2014
Molecular Cell
Discovered a new way to control genetic material altered in cancer
When we speak of genetic material, we are usually referring to the DNA that we inherit from our parents. This DNA is the factory where is built a similar molecule called RNA which produces our proteins, such as hemoglobin or insulin, allowing the lives of our cells. But there is a special group called non-coding RNA that has a more enigmatic function.

Contact: Arantxa Mena
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 5-Jun-2014
Scientists generate long-sought molecular map of critical genetic machinery
A team led by researchers at The Scripps Research Institute has used advanced electron microscopy techniques to determine the first accurate structural map of Mediator, one of the largest and most complex 'molecular machines' in cells. The mapping of its structure -- which includes more than two dozen unique protein subunits--represents a significant advance in basic cell biology and should shed light on medical conditions involving Mediator's dysfunction, from cancer to inherited developmental disorders.
National Institutes of Health, Helen Nelson Medical Research Fund

Contact: Mika Ono
Scripps Research Institute

Public Release: 5-Jun-2014
Analytical Chemistry
Research could lead to new cancer assay, aid both dogs and humans
Veterinary researchers have identified a unique group of proteins that indicate the presence of transitional cell carcinoma -- the most common cause of bladder cancer -- and may lead to a new assay which could better diagnose this disease in both dogs and humans.
NIH/National Insitutes of Environmental Health Sciences

Contact: Shay Bracha
Oregon State University

Public Release: 5-Jun-2014
ASCO 50th Annual Meeting
Race could be a factor in head and neck cancer survival rates, MU researchers find
The national survival rates for African-Americans diagnosed with head and neck cancer have not improved in the last 40 years despite advances in the treatment and management of the disease, University of Missouri School of Medicine researchers have found. The researchers suggest that inherent genetic factors in African-Americans may make some tumors resistant to treatments. However, more research needs to be done on the subject of survival disparity in patients with head and neck cancer.

Contact: Derek Thompson
University of Missouri-Columbia

Public Release: 5-Jun-2014
Brain circuit problem likely sets stage for the 'voices' that are symptom of schizophrenia
St. Jude Children's Research Hospital scientists have identified problems in a connection between brain structures that may predispose individuals to hearing the 'voices' that are a common symptom of schizophrenia. The work appears in the June 6 issue of the journal Science.
National Institutes of Health, American-Lebanese-Syrian Associated Charities

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

Public Release: 5-Jun-2014
European Society for Medical Oncology World Conference on Gastrointestinal Cancer
New therapy for pancreatic cancer patients shows promising results
A clinical trial conducted by researchers at the Virginia G. Piper Cancer Center Clinical Trials, a partnership between Scottsdale Healthcare and the Translational Genomics Research Institute, showed that a new drug called MM-398, given in combination with 5-flourouracil and leucovorin, produced a significant overall survival rate in patients with advanced, previously-treated pancreatic cancer.
Merrimack Pharmaceuticals

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Public Release: 5-Jun-2014
Breast Cancer Research
Can mice mimic human breast cancer? MSU study says 'yes'
Eran Andrechek, a physiology professor in the College of Human Medicine at Michigan State University, has discovered that many of the various models used in breast cancer research can replicate several characteristics of the human disease, especially at the gene level.
National Institutes of Health, Susan G. Komen Foundation

Contact: Sarina Gleason
Michigan State University

Public Release: 5-Jun-2014
ASCO 50th Annual Meeting
Early palliative support services help those caring for patients with advanced cancer
Dartmouth researchers have found that those caring for patients with advanced cancer experienced reduced depression and felt less burdened by caregiving tasks when palliative support services were offered soon after the patient's diagnosis. They presented their findings at the American Society of Clinical Oncologist annual meeting in Chicago on June 3, 2014.

Contact: Robin Dutcher
The Geisel School of Medicine at Dartmouth

Public Release: 5-Jun-2014
Cell Stem Cell
Stem cells hold keys to body's plan
Case Western Reserve researchers have discovered landmarks within pluripotent stem cells that guide how they develop to serve different purposes within the body. This breakthrough offers promise that scientists eventually will be able to direct stem cells in ways that prevent disease or repair damage from injury or illness. The study and its results appear in the June 5 edition of the journal Cell Stem Cell.
National Institutes of Health, New York Stem Cell Foundation, Mount Sinai Health Care Foundation, Case Comprehensive Cancer Center, Case Western Reserve University

Contact: Jeannette Spalding
Case Western Reserve University

Public Release: 4-Jun-2014
Cancer Discovery
Four new genes confirmed to increase familial breast cancer risk
Four new genes have been added to the growing list of those known to cause increased breast cancer risk when mutated through the efforts of researchers at Huntsman Cancer Institute at the University of Utah, who lead an international consortium working to find more gene mutations that cause inherited breast cancer susceptibilities.
National Institutes of Health, Breast Cancer Family Registry, Huntsman Cancer Foundation

Contact: Linda Aagard
University of Utah Health Sciences

Public Release: 4-Jun-2014
Mayo Clinic moves small-molecule drugs through blood-brain barrier
Researchers at Mayo Clinic have demonstrated in a mouse model that their recently developed synthetic peptide carrier is a potential delivery vehicle for brain cancer chemotherapy drugs and other neurological medications.

Contact: Robert Nellis
Mayo Clinic

Public Release: 4-Jun-2014
Medical Physics
New diagnostic imaging techniques deemed safe in simulations
Gamma and neutron imaging offer possible improvements over existing techniques such as X-ray or CT, but their safety is not yet fully understood. Using computer simulations, imaging the liver and breast with gamma or neutron radiation was found to be safe, delivering levels of radiation on par with conventional medical imaging, according to researchers at Duke Medicine.
National Institutes of Health

Contact: Rachel Harrison
Duke University Medical Center

Public Release: 4-Jun-2014
Obestity Surgey
Weight loss surgery also safeguards obese people against cancer
Weight loss surgery might have more value than simply helping morbidly obese people to shed unhealthy extra pounds. It reduces their risk of cancer to rates almost similar to those of people of normal weight. This is the conclusion of the first comprehensive review article taking into account relevant studies about obesity, cancer rates and a weight loss procedure called bariatric surgery. Published in Springer's journal Obesity Surgery, the review was led by Daniela Casagrande.

Contact: Joan Robinson

Public Release: 4-Jun-2014
Journal of Oncology Navigation & Survivorship
GW Cancer Institute conducts survey on moving toward quality patient-centered care
The George Washington University Cancer Institute published research in the Journal of Oncology Navigation and Survivorship on patient navigation and survivorship programs and the challenges many of these programs face.

Contact: Lisa Anderson
George Washington University

Public Release: 3-Jun-2014
Journal of the National Cancer Institute
Study: New test predicts if breast cancer will spread
A test that counts the number of locations in tumor specimens where tumor cells may invade blood vessels predicted the risk of distant spread, or metastasis, for the most common type of breast cancer.
NIH/National Cancer Institute

Contact: Kim Newman
Albert Einstein College of Medicine

Public Release: 3-Jun-2014
Moffitt researchers develop process to help personalize treatment for lung cancer patients
Moffitt Cancer Center researchers, in collaboration with the Lung Cancer Mutation Consortium, have developed a process to analyze mutated genes in lung adenocarcinoma to help better select personalized treatment options for patients. Adenocarcinoma is the most common type of lung cancer in the United States with approximately 130,000 people diagnosed each year.
NIH/National Cancer Institute

Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 3-Jun-2014
Nucleic Acids Research
Deeper than, 'EvoCor' identifies gene relationships
A team led by Gregorio Valdez of the Virginia Tech Carilion Research Institute has designed a search engine that identifies genes that are functionally linked. The discovery may lead to ways to treat diseases that have a genetic component, such as cancer or Alzheimer's.

Contact: Paula Byron
Virginia Tech

Public Release: 3-Jun-2014
New device isolates most aggressive cancer cells
Not all cancer cells are created equal -- some stay put in the primary tumor, while others move and invade elsewhere. A major goal for cancer research is predicting which cells will metastasize, and why. A Cornell cancer research team is taking a new approach to screening for these dangerous cells, using a microfluidic device they invented that isolates only the most aggressive, metastatic cells.
NIH/National Cancer Institute

Contact: Melissa Osgood
Cornell University

Public Release: 3-Jun-2014
Journal of Clinical Endocrinology and Metabolism
Experts recommend blood, urine testing to diagnose rare adrenal tumors
The Endocrine Society today issued a Clinical Practice Guideline for the diagnosis and treatment of two types of rare adrenal tumors -- pheochromocytomas and paragangliomas -- that can raise the risk of cardiovascular disease and even death if left untreated.

Contact: Jenni Glenn Gingery
The Endocrine Society

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