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Showing releases 1176-1200 out of 1316.

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Public Release: 19-Mar-2015
PLOS Computational Biology
Cancer therapy 'tumor sanctuaries' and the breeding ground of resistance
Tumors acquiring resistance is one of the major barriers to successful cancer therapy. Feng Fu, Sebastian Bonhoeffer and their collaborator Martin Nowak use mathematical models to characterize how important aspects of tumor microenvironment can impair the efficacy of targeted cancer therapies.

Contact: Feng Fu
fufeng@gmail.com
41-446-329-303
PLOS

Public Release: 18-Mar-2015
Journal of Pharmacology and Experimental Therapeutics
WSU researchers show how fatty acids can fight prostate cancer
Washington State University researchers have found a mechanism by which omega-3 fatty acids inhibit the growth and spread of prostate cancer cells. The findings, which are at odds with a 2013 study asserting that omega-3s increase the risk of prostate cancer, point the way to more effective anti-cancer drugs.
Washington State University College of Pharmacy

Contact: Kathryn Meier
kmeier@wsu.edu
509-358-7631
Washington State University

Public Release: 18-Mar-2015
Journal of Thoracic Oncology
Early recall rates decline after second round of lung cancer screening
The German Lung Cancer Screening Intervention Trial shows that the early repeat scan rate for suspicious findings decreased by more than 80 percent with the second and subsequent low-dose computed tomography screens, but emphasizes the need to have an organized screening program with the baseline scan available for comparison.

Contact: Murry Wynes
Murry.Wynes@iaslc.org
720-325-2945
International Association for the Study of Lung Cancer

Public Release: 18-Mar-2015
Gut Microbiota For Health World Summit
Exciting data presented at the 4th Gut Microbiota For Health Summit
On March 14-15, 2015, internationally leading experts in gut microbiota research met in Barcelona, Spain, to present the latest findings and discuss their significance for health and diet.

Contact: Aimee Frank
media@gastro.org
301-941-2620
American Gastroenterological Association

Public Release: 18-Mar-2015
Clinical Genitourinary Cancer
NCCS pioneers new drug regimen which reduces toxicities for renal cancer patients
A study led by the Genitourinary oncology team at National Cancer Centre Singapore has revealed conclusive results in reducing toxicities for Asian patients with metastatic renal cell carcinoma or cancer that has spread beyond the kidney.

Contact: Ms. Rachel Tan
rachel.tan.c.h@nccs.com.sg
65-623-69535
SingHealth

Public Release: 18-Mar-2015
Philosophical Transactions of the Royal Society B
Is too much artificial light at night making us sick?
Modern life, with its preponderance of inadequate exposure to natural light during the day and overexposure to artificial light at night, is not conducive to the body's natural sleep/wake cycle. UConn Health cancer epidemiologist Richard Stevens and co-author Yong Zhu from Yale University suggest such overexposure has possible ties to cancer, obesity, diabetes, and other health issues in an article published in the British journal Philosophical Transactions of the Royal Society B.

Contact: Chris DeFrancesco
cdefrancesco@uchc.edu
860-679-3914
University of Connecticut

Public Release: 18-Mar-2015
Journal of Physical Chemistry
Buckyballs become bucky-bombs
Scientists have built nanoscale explosives out of buckyballs that could one day be used to eliminate cancer cells without damaging surrounding tissue.
São Paulo Research Foundation, Brazilian National Council for Scientific and Technological Development, US Department of Energy, Russian Science Foundation

Contact: Robert Perkins
perkinsr@usc.edu
213-740-9226
University of Southern California

Public Release: 18-Mar-2015
Journal of Health Disparities Research Practices
mHealth app ideal for breast cancer risk assessment, prevention
Interviewing women at a breast-imaging center in an urban safety net institution before and after they used a 'mHealth' mobile health app on a tablet, Dartmouth researchers concluded that older, diverse, and low income women found it easy to use and acceptable.
University of California at San Francisco Center for Aging in Diverse Communities, NIH/National Institute on Aging

Contact: Kirk Cassels
Kirk.A.Cassels@Hitchcock.org
603-653-6177
The Geisel School of Medicine at Dartmouth

Public Release: 18-Mar-2015
JAMA
Doctors say women with aytpia or DCIS should seek second opinions after breast biopsies
While doctors almost always agree on a pathological diagnosis of invasive breast cancer, there is room for improvement when diagnosing atypia (or atypical ductal hyperplasia-ADH) and DCIS (ductal carcinoma in-situ), Dartmouth researchers have found.
NIH/National Cancer Institute, NCI Breast Cancer Surveillance Consortium

Contact: Kirk Cassels
603-653-6177
The Geisel School of Medicine at Dartmouth

Public Release: 17-Mar-2015
JAMA
The link between aspirin, NSAIDs and colon cancer prevention may hinge on genetic variations
The link between taking aspirin, non-steroidal anti-inflammatory drugs, or NSAIDS, and colorectal cancer prevention is well established, but the mechanisms behind the protective effect have not been understood. A new study, co-led by investigators at Fred Hutchinson Cancer Research Center and published March 17 in JAMA, suggests this protection differs according to variations in DNA.
NIH/National Cancer Institute, National Institutes of Health, US Department of Health and Human Services

Contact: Kristen Woodward
kwoodwar@fredhutch.org
206-667-5095
Fred Hutchinson Cancer Research Center

Public Release: 17-Mar-2015
JAMA
Study examines diagnostic accuracy of pathologists interpreting breast biopsies
In a study in which pathologists provided diagnostic interpretation of breast biopsy slides, overall agreement between the individual pathologists' interpretations and that of an expert consensus panel was 75 percent, with the highest level of concordance for invasive breast cancer and lower levels of concordance for ductal carcinoma in situ and atypical hyperplasia, according to a study in the March 17 issue of JAMA.

Contact: Susan Gregg
sghanson@uw.edu
The JAMA Network Journals

Public Release: 17-Mar-2015
JAMA
Genetic background determines whether aspirin/NSAIDS will reduce colorectal cancer risk
An analysis of genetic and lifestyle data from 10 large epidemiologic studies confirmed that regular use of aspirin or NSAIDs appears to reduce the risk of colorectal cancer in most individuals but also found that a few individuals with rare genetic variants do not share this benefit.
NIH/National Cancer Institute, NIH/National Institute for Diabetes and Digestive and Kidney Diseases

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital

Public Release: 17-Mar-2015
Lancet Oncology
Study suggests precision medicine for adrenal cancer
In a randomized phase 3 trial, adrenal cancer patients receiving the investigational drug linsitinib fared no better than patients receiving a placebo. But the researchers noticed a small subset of patients who had significant response and remained on the drug for an extended time.
Astellas

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 17-Mar-2015
JAMA
Effect of aspirin, NSAIDs on colorectal cancer risk may differ from genetic variations
Among approximately 19,000 individuals, the use of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) was associated with an overall lower risk of colorectal cancer, although this association differed according to certain genetic variations, according to a study in the March 17 issue of JAMA.

Contact: Katie Marquedant
KMARQUEDANT@PARTNERS.ORG
The JAMA Network Journals

Public Release: 17-Mar-2015
Clinical Cancer Research
Macrophages may play critical role in melanoma resistance to BRAF inhibitors
Researchers at The Wistar Institute have discovered one way in which melanoma becomes resistant to a particular form of targeted therapy, and understanding this phenomenon may lead to a new melanoma target or prompt new designs of these treatments.
National Institutes of Health, Commonwealth Universal Research Enhancement Program of the Pennsylvania Department of Health, The Wistar Institute Intramural Grants

Contact: Ben Leach
bleach@wistar.org
215-495-6800
The Wistar Institute

Public Release: 17-Mar-2015
International Journal of Cancer
Microenvironment provides growth factor for metastasis
When a person has cancer that spreads to the bone and bone marrow, the tissue becomes increasingly fragile, often leading to increased bone resorption. In a surprising discovery, investigators at Children's Hospital Los Angeles found that when neuroblastoma cells metastasize to the bone, there initially occurs an increase in bone deposition, not resorption. They also determined that this process is driven by a chemical messenger called VEGFA.
National Institutes of Health, Ruth L. Kirschstein National Research Service Award

Contact: Ellin Kavanagh
ekavanagh@chla.usc.edu
323-361-7628
Children's Hospital Los Angeles

Public Release: 17-Mar-2015
Nature Structural & Molecular Biology
3-D snapshot of protein highlights potential drug target for breast cancer
One of 15 different polymerases tasked with copying our genetic material, POLQ is singled out in this study for its unique role -- captured in an X-ray crystallography visual -- in DNA repair pathways linked to breast cancer, and therefore, potential as a drug target.
National Institutes of Health, Cancer Prevention and Research Institute of Texas, Grady F. Saunders, Ph.D., Distinguished Research Professorship, NIH/National Cancer Institute, NIH/National Institute of General Medical Sciences

Contact: Jennifer Nachbur
jennifer.nachbur@med.uvm.edu
802-656-7875
University of Vermont

Public Release: 17-Mar-2015
Zootaxa
Researchers describe 5 new species of marine invertebrates
Brazilian researchers described five new species of ascidians, commonly known as sea squirts, ascidians are marine invertebrates that generally form permanently submerged colonies. Exotic molecules obtained from research on ascidians have been explored worldwide for use in combating cancer.
São Paulo Research Foundation

Contact: Samuel Antenor
samuel@fapesp.br
55-113-838-4381
Fundação de Amparo à Pesquisa do Estado de São Paulo

Public Release: 17-Mar-2015
JAMA
Genetic markers play role in who benefits from aspirin, NSAIDs to lower colon cancer risk
An Indiana University cancer researcher and her colleagues have identified genetic markers that may help determine who benefits from regular use of aspirin and other nonsteroidal anti-inflammatory drugs for lowering one's risk of developing colorectal cancer.
National Institutes of Health

Contact: Michael Schug
maschug@iupui.edu
317-278-0953
Indiana University

Public Release: 17-Mar-2015
Journal of Economic Perspectives
Study: Prices of cancer drugs have soared since 1995
The prices of leading cancer drugs have risen at rates far outstripping inflation over the last two decades, according to a new study co-authored by an MIT economist -- but the exact reasons for the cost increases are unclear.
NIH/National Cancer Institute

Contact: Abby Abazorius
abbya@mit.edu
617-253-2709
Massachusetts Institute of Technology

Public Release: 16-Mar-2015
PLOS ONE
Predicting prostate cancer
A Northwestern University-led study in the emerging field of nanocytology could one day help men make better decisions about whether or not to undergo aggressive prostate cancer treatments.
National Institutes of Health, John and Carol Walter Center for Urological Health

Contact: Erin Spain
Spain@northwestern.edu
847-491-4888
Northwestern University

Public Release: 16-Mar-2015
Cell
Scientists find DNA is packaged like a yoyo
A research team led by University of Illinois professor of physics Taekjip Ha has found that DNA uncoils from the nucleosome asymmetrically (uncoiling from one end much more easily) in a recent publication in Cell.
National Science Foundation, National Institutes of Health, Howard Hughes Medical Institute

Contact: Nicholas Vasi
nvasi@illinois.edu
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign

Public Release: 16-Mar-2015
MD Anderson study, new hepatitis C drugs will place strain on health care system
The cost of treating people infected with the hepatitis C virus (HCV) with newly approved therapies will likely place a tremendous economic burden on the country's health care system. The prediction comes from a cost-effectiveness analysis led by researchers at the University of Texas MD Anderson Cancer Center.

Contact: Katrina Burton
kburton@mdanderson.org
713-792-8034
University of Texas M. D. Anderson Cancer Center

Public Release: 16-Mar-2015
Nature Plants
University of Sydney: Discovery holds promise for gene therapy and agriculture
A key step in understanding the genetic mechanism of plants' environmental adaptability has made in research led by the University of Sydney.

Contact: Verity Leatherdale
verity.leatherdale@sydney.edu.au
61-403-067-342
University of Sydney

Public Release: 16-Mar-2015
Nature Reviews Immunology
Investigators find window of vulnerability for STIs to infect female reproductive tract
Dartmouth researchers have presented a comprehensive review of the role of sex hormones in the geography of the female reproductive tract and evidence supporting a 'window of vulnerability' to HIV and other sexually transmitted infections.
National Institutes of Health

Contact: Kirk Cassels
Kirk.A.Cassels@Hitchcock.org
603-653-6177
The Geisel School of Medicine at Dartmouth

Showing releases 1176-1200 out of 1316.

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