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Public Release: 10-Feb-2014
Angewandte Chemie International Edition
Nanomotors are controlled, for the first time, inside living cells
Nanomotors have been controlled inside living cells for the first time, report a team of chemists and engineers at Penn State University. The scientists placed tiny rocket-shaped synthetic motors inside live human cells, propelled them with ultrasonic waves and steered them magnetically to spin and to battering against the cell membrane.
National Science Foundaiton, National Institutes of Health, Penn State University

Contact: Barbara K. Kennedy
Penn State

Public Release: 10-Feb-2014
Smoking linked with increased risk of most common type of breast cancer
Young women who smoke and have been smoking a pack a day for a decade or more have a significantly increased risk of developing the most common type of breast cancer. That is the finding of an analysis published early online in Cancer, a peer-reviewed journal of the American Cancer Society. The study indicates that an increased risk of breast cancer may be another health risk incurred by young women who smoke.

Contact: Evelyn Martinez

Public Release: 10-Feb-2014
Cancer Cell
Weakness exposed in most common cancer gene
NYU Langone Medical Center researchers have found a biological weakness in the workings of the most commonly mutated gene involved in human cancers, known as mutant K-Ras, which they say can be exploited by drug chemotherapies to thwart tumor growth.

Contact: David March
NYU Langone Medical Center / New York University School of Medicine

Public Release: 10-Feb-2014
American Journal of Pathology
Clues to cancer pathogenesis found in cell-conditioned media
Primary effusion lymphoma (PEL) is a rare B-cell neoplasm distinguished by its tendency to spread along the thin serous membranes that line body cavities without infiltrating or destroying nearby tissue. By growing PEL cells in culture and analyzing the secretome (proteins secreted into cell-conditioned media), investigators have identified proteins that may explain PEL pathogenesis, its peculiar cell adhesion, and migration patterns. They also recognized related oncogenic pathways, thereby providing rationales for more individualized treatment.
Ministero della Salute, Rome, Centro di Riferimento Oncologico Aviano, Italy

Contact: Eileen Leahy
Elsevier Health Sciences

Public Release: 10-Feb-2014
Proceedings of the National Academy of Sciences
Better RNA interference, inspired by nature
New MIT nanoparticles offer best-ever gene silencing, could help treat liver diseases.
Alnylam Pharmaceuticals, National Institutes of Health

Contact: Sarah McDonnell
Massachusetts Institute of Technology

Public Release: 10-Feb-2014
EU rules are denying children latest cancer drugs
Children with cancer are being denied new, potentially life-saving drugs, because EU rules are allowing companies to trial some drugs only in adults, leading cancer experts warn today.

Contact: Henry French
Institute of Cancer Research

Public Release: 10-Feb-2014
Annals of Oncology
EORTC characterizes responders & survivors on pazopanib for advanced soft tissue sarcoma
An EORTC analysis appearing in Annals of Oncology confirmed the importance of known prognostic factors such as performance status and tumor grading for having a long-term outcome in patients treated with pazopanib for metastatic soft tissue sarcoma. Additionally, hemoglobin at baseline was found to be a new prognostic factor.
European Organisation for Research and Treatment of Cancer Charitable Trust

Contact: John Bean
European Organisation for Research and Treatment of Cancer

Public Release: 10-Feb-2014
Cell Reports
Mayo Clinic identifies a key cellular pathway in prostate cancer
Mayo Clinic researchers have shed light on a new mechanism by which prostate cancer develops in men.

Contact: Robert Nellis
Mayo Clinic

Public Release: 10-Feb-2014
TGen study uncovers possible genetic markers in breast cancer that spreads to the brain
The Translational Genomics Research Institute has uncovered possible genetic origins of breast cancer that spreads to the brain, according to a first-of-its-kind study published in the scientific journal PLOS ONE.
National Institutes of Health, Flinn Foundation, C.A.R.E.

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Public Release: 10-Feb-2014
International Journal of Radiation Oncology Biology Physics
ASTRO and SSO issue consensus guideline on margins for breast-conserving surgery with WBI
The American Society for Radiation Oncology and the Society of Surgical Oncology are pleased to announce the publication of the consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer.
Susan G. Komen Foundation

Contact: Michelle Kirkwood
American Society for Radiation Oncology

Public Release: 10-Feb-2014
EMBO Molecular Medicine
Study reveals unexpected cell hijack method in pancreatic cancer
Pancreatic stellate cells, which normally aid tissue repair, unwittingly help pancreatic cancer grow and spread in a method of "cell hijack" only seen before in brain and breast cancer, according to new research from Queen Mary University of London.
Pancreatic Cancer Research Fund

Contact: Charli Scouller
Queen Mary, University of London

Public Release: 10-Feb-2014
Cancer Cell
Normal enzyme aids a mutant 1 to fuel blood cancer's growth
Researchers from Dana-Farber/Boston Children's Cancer and Blood Disorders Center report that a normal enzyme called SYK pairs with FLT3, the most commonly mutated enzyme found in acute myelogenous leukemia (AML), to promote the cancer's growth. This partnership also promotes AML cells' resistance to treatment with FLT3-blocking drugs and could explain the relatively poor showing of FLT3 inhibitors in clinical studies.
NIH/National Cancer Institute, American Cancer Society

Contact: Irene Sege
Dana-Farber Cancer Institute

Public Release: 9-Feb-2014
Nature Genetics
Study involving twin sisters provides clues for battling aggressive cancers
Analyzing the genomes of twin sisters -- one healthy and one with aggressive leukemia -- led an international team of researchers to identify a novel molecular target that could become a way to treat recurring and deadly malignancies. Scientists report their findings online Feb. 9 in Nature Genetics. The study points to a molecular pathway involving a gene called SETD2, which can mutate in blood cells during a critical step as DNA is being transcribed and replicated.

Contact: Nick Miller
Cincinnati Children's Hospital Medical Center

Public Release: 9-Feb-2014
Nature Chemical Biology
Scientists invent advanced approach to identify new drug candidates from genome sequence
In research that could ultimately lead to many new medicines, scientists from the Florida campus of The Scripps Research Institute have developed a potentially general approach to design drugs from genome sequence. As a proof of principle, they identified a highly potent compound that causes cancer cells to attack themselves and die.
National Institutes of Health, Camille and Henry Dreyfus Foundation

Contact: Eric Sauter
Scripps Research Institute

Public Release: 6-Feb-2014
Annals of Neurology
Gender influences symptoms of genetic disorder
Researchers at Washington University School of Medicine in St. Louis have identified a patient's gender as a clear and simple guidepost to help health-care providers anticipate some of the complex effects of NF1, a genetic disorder.

Contact: Michael C. Purdy
Washington University School of Medicine

Public Release: 6-Feb-2014
Current Biology
Birds of a different color
Scientists at the University of Utah identified mutations in three key genes that determine feather color in domestic rock pigeons. The same genes control pigmentation of human skin, and mutations in them can be responsible for melanoma and albinism.
National Science Foundation, Burroughs Wellcome Fund, National Institutes of Health, Huntsman Cancer Foundation, Tom C. Mathews Jr. Familial Melanoma Research Clinic Endowment

Contact: Lee J. Siegel
University of Utah

Public Release: 6-Feb-2014
Cell Reports
CNIO researchers propose a new combined therapy to treat cancer
Marcos Malumbres, a researcher at the Spanish National Cancer Research Centre, and his team have discovered how etoposide -- a drug widely used in the treatment of lung and testicular cancers, leukemias and brain tumors -- could increase its efficiency and specificity in combination with other compounds that interfere with cell division. The results are published today in the journal Cell Reports.

Contact: Nuria Noriega
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 6-Feb-2014
Stem Cell Reports
Prostate development discovery could lead to new treatments
Scientists at the University of York have discovered how the prostate gland develops for the first time, according to research published today, Thursday, Feb. 6, in Stem Cell Reports.

Contact: David Garner
University of York

Public Release: 6-Feb-2014
A microchip for metastasis
A new microfluidic platform shows how cancer cells invade specific organs.
NIH/National Cancer Institute, Italian Ministry of Health

Contact: Kimberly Allen
Massachusetts Institute of Technology

Public Release: 6-Feb-2014
SPIE Photonics WEST 2014
Credit card-sized device could analyze biopsy, help diagnose pancreatic cancer in minutes
University of Washington scientists and engineers are developing a low-cost device that could help pathologists diagnose pancreatic cancer earlier and faster. The prototype can perform the basic steps for processing a biopsy, relying on fluid transport instead of human hands to process the tissue.

Contact: Michelle Ma
University of Washington

Public Release: 6-Feb-2014
Cell Reports
A key facilitator of mRNA editing uncovered by IU researchers
Molecular biologists from Indiana University are part of a team that has identified a protein that regulates the information present in a large number of messenger ribonucleic acid molecules that are important for carrying genetic information from DNA to protein synthesis.
National Science Foundation, National Institutes of Health, Sloan Foundation, Showalter Foundation, Indiana University School of Medicine

Contact: Steve Chaplin
Indiana University

Public Release: 5-Feb-2014
National poll shows public divided on genetic testing to predict cancer risk
A national poll from Utah's Huntsman Cancer Institute shows 34 percent of respondents would not seek genetic testing to predict their likelihood of developing a hereditary cancer. The poll also shows only 35 percent of respondents would be extremely or very likely to seek aggressive prophylactic or preventive treatment if they had a family history of cancer and genetic testing indicated a genetic predisposition to cancer.
University of Utah

Contact: Linda Aagard
University of Utah Health Sciences

Public Release: 5-Feb-2014
Healthcare: The Journal of Delivery Science and Innovation
MD Anderson guides intelligent redesign of cancer care delivery model
How best to implement key recommendations recently identified by the Institute of Medicine for the delivery of high-quality cancer care is the focus of two peer-reviewed articles from The University of Texas MD Anderson Cancer Center.

Contact: Julie Penne
University of Texas M. D. Anderson Cancer Center

Public Release: 5-Feb-2014
Mechanism discovered for how amyotrophic lateral sclerosis mutations damage nerve function
St. Jude Children's Research Hospital scientists led a study showing that mutations in a gene responsible for amyotrophic lateral sclerosis disrupt the RNA transport system in nerve cells. The findings appear in the current issue of the scientific journal Neuron and offer a new focus for efforts to develop effective treatments.
Packard Foundation, Muscular Dystrophy Association, Amyotrophic Lateral Sclerosis Association, National Institutes of health, NIH/National Cancer Institute, American Lebanese Syrian Associated Charities

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

Public Release: 4-Feb-2014
Advances in Urology
3D mapping biopsy finds 3x prostate cancer of ultrasound-guided biopsy
University of Colorado Cancer Center study reports locations of most-missed pockets of prostate cancer.

Contact: Garth Sundem
University of Colorado Denver

Showing releases 1176-1200 out of 1278.

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