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Showing releases 1201-1225 out of 1243.

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Public Release: 1-May-2014
Clinical Cancer Research
Vitamin D deficiency may be linked to aggressive prostate cancer
Vitamin D deficiency was an indicator of aggressive prostate cancer and spread of the disease in European-American and African-American men who underwent their first prostate biopsy because of abnormal prostate-specific antigen and/or digital rectal examination test results, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.
National Institutes of Health, US Department of Defense

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 1-May-2014
Population Association of America Annual Meeting
'Til sickness do us part: How illness affects the risk of divorce
In the classic marriage vow, couples promise to stay together in sickness and in health. But a new study finds that the risk of divorce among older married couples rises when the wife -- but not the husband -- becomes seriously ill.

Contact: Diane Swanbrow
University of Michigan

Public Release: 1-May-2014
Journal of Leukocyte Biology
Scientists discover endogenous dendritic cell-derived interleukin-27 promotes tumor growth
In a new report published in the Journal of Leukocyte Biology, scientists lay the groundwork for the development of novel tumor therapies that may help rid the body of cancer by inhibiting the recruitment of a specific suppressive immune cell type called 'regulatory T-cells.'

Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Public Release: 1-May-2014
Cell Reports
Gene discovery links cancer cell 'recycling' system to potential new therapy
University of Rochester scientists have discovered a gene with a critical link to pancreatic cancer, and further investigation in mice shows that by blocking the gene's most important function, researchers can slow the disease and extend survival.
National Institutes of Health

Contact: Leslie Orr
University of Rochester Medical Center

Public Release: 1-May-2014
Cancer Research
New model can predict therapy outcomes in prostate cancer with bone metastasis
A new computational model that simulates bone metastasis of prostate cancer has the potential to rapidly assess experimental therapy outcomes and help develop personalized medicine for patients with this disease, according to data published in Cancer Research, a journal of the American Association for Cancer Research.
US Department of Defense, NIH/National Cancer Institute

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 1-May-2014
Clinical Cancer Research
Human fat: A trojan horse to fight brain cancer?
Johns Hopkins researchers say they have successfully used stem cells derived from human body fat to deliver biological treatments directly to the brains of mice with the most common and aggressive form of brain tumor, significantly extending their lives.
NIH/National Institute of Neurological Disorders and Stroke

Contact: Stephanie Desmon
Johns Hopkins Medicine

Public Release: 1-May-2014
Science Signaling
'Achilles heel' of pancreatic cancer identified
A research team at Georgetown Lombardi Comprehensive Cancer Center reports that inhibiting a single protein completely shuts down growth of pancreatic cancer, a highly lethal disease with no effective therapy. 'We believe this is the true Achilles heel of pancreatic cancer ... This appears to be the critical switch that promotes cancer growth and progression,' says the study's senior investigator.
NIH/National Cancer Institute, Burroughs Wellcome Clinical Scientist Award

Contact: Karen Teber
Georgetown University Medical Center

Public Release: 1-May-2014
Clinical Cancer Research
Vitamin D deficiency linked to aggressive prostate cancer
African-American and European-American men at high risk of prostate cancer have greater odds of being diagnosed with an aggressive form of the disease if they have a vitamin D deficiency.
National Institutes of Health, US Department of Defense

Contact: Erin White
Northwestern University

Public Release: 30-Apr-2014
American Society of Breast Surgeons Annual Meeting
Surgeons and health care settings influence type of breast cancer surgery women undergo
Breast cancer is one of the few major illnesses for which physicians may not recommend a specific treatment option. North American women are more likely to opt for precautionary breast surgery when physicians don't specifically counsel against it, according to a new study.

Contact: Geoff Koehler
416-864-6060 x6537
St. Michael's Hospital

Public Release: 30-Apr-2014
JAMA Dermatology
Study examines UV nail salon lamps, risk of skin cancer
Using higher-wattage ultra violet lamps at nail salons to dry and cure polish was associated with more ultra violet-A radiation being emitted, but the brief exposure after a manicure would require multiple visits for potential DNA damage and the risk for cancer remains small.

Contact: Jennifer Scott
The JAMA Network Journals

Public Release: 30-Apr-2014
94th AATS Annual Meeting
CT in the operating room allows more precise removal of small lung cancers
A new technique that brings CT imaging into the operating room will allow surgeons to precisely demarcate and remove small sub-centimeter lung nodules, leaving as much healthy tissue as possible, according to Raphael Bueno, M.D., of Brigham and Women's Hospital in Boston. His team is presenting the results of this late-breaking research at the 94th AATS Annual Meeting in Toronto, ON, Canada on April 30, 2014.

Contact: Nicole Baritot
American Association for Thoracic Surgery

Public Release: 30-Apr-2014
Academic Pediatrics
Coached extracurricular activities may help prevent pre-adolescent smoking and drinking
Dartmouth researchers have found that tweens (preadolescents aged 10-14) who participate in a coached team sport a few times a week or more are less likely to try smoking. Their findings on the relationship between extracurricular activity and health risk behaviors are reported in 'The relative roles of types of extracurricular activity on smoking and drinking initiation among tweens,' which was recently published in Academic Pediatrics.
National Institutes of Health, NIH/National Cancer Institute

Contact: Robin Dutcher
The Geisel School of Medicine at Dartmouth

Public Release: 30-Apr-2014
Genes and Development
Damage control: Recovering from radiation and chemotherapy
Researchers at the University of California, San Diego School of Medicine report that a protein called beta-catenin plays a critical, and previously unappreciated, role in promoting recovery of stricken hematopoietic stem cells after radiation exposure.
National Institutes of Health, California Institute for Regenerative Medicine

Contact: Scott LaFee
University of California - San Diego

Public Release: 30-Apr-2014
Water-based 'engine' propels tumor cells through tight spaces in the body
Johns Hopkins researchers have discovered how cancer cells spread through extremely narrow three-dimensional spaces in the body, identifying a propulsion system based on water and charged particles.
National Science Foundatoin, NIH/National Cancer Institute

Contact: Phil Sneiderman
Johns Hopkins University

Public Release: 30-Apr-2014
American Society of Breast Surgeons Annual Meeting
Lymph node ultrasounds more accurate in obese breast cancer patients
Mayo Clinic research into whether ultrasounds to detect breast cancer in underarm lymph nodes are less effective in obese women has produced a surprising finding. Fat didn't obscure the images -- and ultrasounds showing no suspicious lymph nodes actually proved more accurate in overweight and obese patients than in women with a normal body mass index, the study found.

Contact: Sharon Theimer
Mayo Clinic

Public Release: 30-Apr-2014
Journal of American Chemical Society
Cutting cancer to pieces: New research on bleomycin
In a new study, lead author Basab Roy -- a researcher at Arizona State University's Biodesign Institute -- describes bleomycin's ability to cut through double-stranded DNA in cancerous cells, like a pair of scissors. Such DNA cleavage often leads to cell death in particular types of cancer cells.

Contact: Joseph Caspermeyer
Arizona State University

Public Release: 30-Apr-2014
Salk Institute study identifies novel regulator of key gene expression in cancer
Scientists at the Salk Institute for Biological Studies have identified a key genetic switch linked to the development, progression and outcome of cancer, a finding that may lead to new targets for cancer therapies.

Contact: Chris Emery
Salk Institute

Public Release: 30-Apr-2014
International Journal of Epidemiology
Prostate cancer and blood lipids share genetic links
A new study by researchers at the University of California, San Diego School of Medicine, with colleagues in Norway, significantly refines the association, highlighting genetic risk factors associated with low density lipoprotein cholesterol and triglycerides as key players and identifying 17 related gene loci that make risk contributions to levels of these blood lipids and to prostate cancer.
Kristian Gerhard Jebsen Foundation, Centre for Molecular Medicine Norway

Contact: Scott LaFee
University of California - San Diego

Public Release: 29-Apr-2014
Lancet Oncology
NCI, NCRI and EORTC outline risk-assessment approach for biomarker-driven cancer clinical trials
In an article published in The Lancet Oncology, an NCI, NCRI, and EORTC working group outline a practical risk-management approach for effective integration of biomarkers into cancer clinical trials. Their work provides the international community with a set of common principles by which biomarkers can be integrated into clinical trials, exchange of data can be facilitated, quality promoted, and research accelerated while simultaneously respecting local approaches and legislation.
EORTC Charitable Trust, UK Department of Health

Contact: John Bean
European Organisation for Research and Treatment of Cancer

Public Release: 29-Apr-2014
Microfluidic technology reveals potential biomarker for early pancreatic cancer
The findings, published in Gastroenterology, revealed circulating pancreas cells seed the bloodstream before tumors can be detected using current clinical tests. The data suggest that the detection of pancreas cells in the blood may be an early sign of cancer.
Naitonal Institutes of Health

Contact: Shantell M. Kirkendoll
University of Michigan Health System

Public Release: 29-Apr-2014
Genome Biology
Like puzzle pieces, 3-D genomics holds a key to classifying human diseases
To solve a puzzle, you need to recognize shapes, patterns and a particular kind of order. In much the same way, researchers at McGill University have discovered that the 3-D shape of a leukemia cell's genome holds a key to solving the puzzle of human diseases. The researchers report their findings in the open access journal Genome Biology.

Contact: Cynthia Lee
McGill University

Public Release: 29-Apr-2014
Nature Communications
UNC researchers discover 'master regulator' role for little-known protein in cancer cells
Researchers in the UNC School of Medicine found that the protein DAZAP1 plays a key role in the regulation of many genes through a process known as alternative splicing, and when highly expressed in cancer cell line experiments, DAZAP1 was shown to inhibit several types of cancer cells from dividing and moving. The discovery, published in the journal Nature Communications, marks the first time this little-known protein has been characterized in relation to cancer development and tumor growth.

Contact: Mark Derewicz
University of North Carolina Health Care

Public Release: 29-Apr-2014
Clinical Cancer Research
CNIO team presents a new strategy to personalise cancer therapies
Researchers led by Manuel Hidalgo, Vice-Director of Translational Research at CNIO, have developed a new strategy to personalized medicine in advanced cancer patients with a poor prognosis. The study has been published in the journal Clinical Cancer Research. Applying this new tool, the treatments induced clinical responses in up to 77 percent of patients, either through the stabilization of their condition or through a partial clinical response.

Contact: Nuria Noriega
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 29-Apr-2014
Journal of Health Communication
Anti-smoking TV ads should use anger, Dartmouth-Cornell study suggests
Anti-smoking television advertisements that appeal to viewers' emotions are more persuasive when they use anger rather than sadness, a Dartmouth-Cornell study suggests.

Contact: John Cramer
Dartmouth College

Public Release: 29-Apr-2014
ACS Nano
Brain tumor cells penetrated by tiny, degradable particles carrying genetic instructions
Working together, Johns Hopkins biomedical engineers and neurosurgeons report that they have created tiny, biodegradable 'nanoparticles' able to carry DNA to brain cancer cells in mice. The team says the results of their proof of principle experiment suggest that such particles loaded with 'death genes' might one day be given to brain cancer patients during neurosurgery to selectively kill off any remaining tumor cells without damaging normal brain tissue.
NIH/National Institute of Biomedical Imaging and Bioengineering, NIH/National Cancer Institute, Maryland Stem Cell Research Fund, Technology Development Corporation

Contact: Catherine Kolf
Johns Hopkins Medicine

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