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Showing releases 1201-1225 out of 1386.

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Public Release: 1-Feb-2016
Cancer Epidemiology, Biomarkers & Prevention
Appalachia continues to have higher cancer rates than the rest of US but gap is narrowing
Men and women in Appalachia continue to have higher cancer incidence rates compared with those in the rest of the United States regardless of race or location. The disparity is attributed in part to high tobacco use, potential differences in socioeconomic status, and patient health care utilization.
Centers for Disease Control and Prevention

Contact: Lauren Riley
American Association for Cancer Research

Public Release: 29-Jan-2016
Journal of the National Cancer Institute
Oncologists issue guidance for allocating scarce chemotherapy drugs
Claiming that clinicians lack formal and concrete allocation guidance when faced with a critical drug shortage, experts in pediatric oncology and bioethics have issued a framework to avoid waste and guide difficult prioritization decisions among children in need of scarce life-saving chemotherapy treatment. The commentary is published Jan. 29 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
Oxford University Press USA

Public Release: 29-Jan-2016
Lancet Oncology
Proton therapy controls common pediatric brain tumor with fewer long-term side effects
The use of proton radiotherapy to treat the most common malignant brain tumor in children is as effective as standard photon (X-ray) radiation therapy while causing fewer long-term side effects such as hearing loss and cognitive disorders.
NIH/National Cancer Institute

Contact: Katie Marquedant
Massachusetts General Hospital

Public Release: 29-Jan-2016
Nature Communications
Vital clues to future cancer development in normal breast tissue DNA
Detecting molecular alterations in early breast cancer development is key in the development of more effective cancer prevention and early detection strategies. New research funded by the Eve Appeal and the European Union's Seventh Framework Program, published today in science journal Nature Communications shows clear evidence that DNA changes are already present in the healthy tissue from women with breast cancer.
Eve Appeal, European Union's Seventh Framework Program

Contact: Wesley Hutchins
University College London

Public Release: 29-Jan-2016
Molecular Cancer Therapeutics
A new class of drug slows growth of castration-resistant prostate cancer cells
Sphingosine kinase inhibitors are a new category of drugs that act on specific enzymes involved in sphingolipid metabolism to reduce the formation of a pro-cancer, pro-inflammatory lipid signaling molecule known as sphingosine-1 phosphate (S1P). Preclinical studies led by immunologist Christina Voelkel-Johnson, Ph.D., of the Medical University of South Carolina showed that a first-in-class sphingosine kinase 2 inhibitor slowed growth of aggressive prostate cancer cells.
The MUSC Hollings Cancer Center's Cancer Center Support Grant, Medical University of South Carolina, National Center for Research Resources, Office of the Director of the National Institututes of Health

Contact: Heather Woolwine
Medical University of South Carolina

Public Release: 29-Jan-2016
Plastic and Reconstructive Surgery
Fat injection for breast reconstruction doesn't increase risk of recurrent breast cancer
For women undergoing breast cancer surgery, a technique called lipofilling -- using the patient's own fat cells to optimize the results of breast reconstruction -- does not increase the risk of recurrent breast cancer, reports a study in the February issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons.

Contact: Connie Hughes
Wolters Kluwer Health

Public Release: 29-Jan-2016
Technology and Innovation
Spotlight on both old, difficult issues and humanitarian visions that drive new patents
The current issue of Technology and Innovation has articles on the 2015 Patents for Humanity Awards, asbestos exposure during outdoor recreational activities, the phenomenon of academic serial inventors, and a special section on regulatory science with articles on organic vs. conventional foods and the critical role of review criteria in peer review.

Contact: Kimberly Macuare
University of South Florida (USF Innovation)

Public Release: 28-Jan-2016
JAMA Oncology
Genomics studies assess childhood, young adulthood cancers
Genomics assessments of childhood and young adulthood cancers are the subject of two new studies, an editorial and an author audio interview published online by JAMA Oncology.

Contact: Anne Doerr
The JAMA Network Journals

Public Release: 28-Jan-2016
Nucleic Acids Research
Toward a better understanding of the mechanisms blocking cancer cell growth
A study published in the journal Nucleic Acids Research provides valuable information about certain mechanisms governing DNA repair and opens the way to better understand the mechanisms of action of drugs that prevent cancer cell growth.
Canadian Institutes of Health Research, Institut Mérieux, Cole Foundation

Contact: Julie Gazaille
University of Montreal

Public Release: 28-Jan-2016
JAMA Oncology
Fertility issues for patients with cancer examined in collection of articles
A collection of articles published online by JAMA Oncology examines fertility issues, both regarding clinical care and legal questions, in patients with cancer.

Contact: Claudia L. Maj
The JAMA Network Journals

Public Release: 28-Jan-2016
Cell Reports
Researchers tease apart a pathway certain cancer cells use to replicate
A new 'player' in the way certain aggressive cancer cells may reproduce has been identified. It is hoped that these findings may lead to the identification of new cancer targets and may ultimately lead to new therapeutics.
National Institutes of Health Pathway to Independence Award , Karin Grunebaum Cancer Research Foundation, Peter Paul Professorship, Cancer Research Society/Société de recherche sur le cancer

Contact: Gina DiGravio
Boston University Medical Center

Public Release: 28-Jan-2016
A cancer's surprise origins, caught in action
Researchers at Boston Children's Hospital have, for the first time, visualized the origins of cancer from the first affected cell and watched its spread in a live animal.
National Institutes of Health, NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases, the Ellison Foundation, the Melanoma Research Alliance, the V Foundation and the Howard Hughes Medical Institute

Contact: Keri Stedman
Boston Children's Hospital

Public Release: 28-Jan-2016
New molecular profiling for glioma
Cell publishes on its Jan. 28th edition the results of the largest study ever performed on the molecular profiles of gliomas -- that represent 80 percent of tumors of the central nervous system.
São Paulo Research Foundation, Cancer Prevention & Research Institute of Texas, National Institutes of Health

Contact: USP Scientific Outreach Unit
University of Sao Paulo Scientific Outreach Unit

Public Release: 28-Jan-2016
TSRI study reveals workings of mysterious 'relief valve' that protects cells from swelling
Solving a long-standing mystery in cell biology, a team has shown how a key 'relief-valve' in cells keeps cells from taking in too much water and swelling excessively. The mechanism has been tentatively linked to stroke-induced brain damage, diabetes, immune deficiency and even cancer treatment resistance.
National Institutes of Health, Howard Hughes Medical Institute

Contact: Madeline McCurry-Schmidt
Scripps Research Institute

Public Release: 28-Jan-2016
JAMA Oncology
Genetic sequencing can help guide treatment in children with solid tumors
Clinical genomic sequencing is feasible in pediatric oncology and can be used to recommend therapy or pinpoint diagnosis in children with solid tumors, according to the multi-center Individualized CAncer Therapy (iCat) study led by investigators from Dana-Farber/Boston Children's Cancer and Blood Disorders Center.
Hyundai Hope on Wheels, Friends for Life Foundation, Gillmore Fund

Contact: Anne Doerr
Dana-Farber Cancer Institute

Public Release: 28-Jan-2016
New insights into PI3K pathway and cancer metabolism
New research led by scientists at Beth Israel Deaconess Medical Center (BIDMC) provides important insights into the biology that underlies glycolysis, the metabolic process that enables cancer cells to generate biomass and energy, confirming the importance of sugar to cancer survival.
NIH/National Cancer Institute, National Science Foundation, Stand Up 2 Cancer, Breast Cancer Research Foundation, Mary Kay Ash Foundation, Damon Runyon Cancer Research Foundation

Contact: Bonnie Prescott
Beth Israel Deaconess Medical Center

Public Release: 28-Jan-2016
Cell Reports
The CNIO uses the Internet network theory to decipher the first epigenetic communication network
The discovery, published in 'Cell Reports', is the first communication network between the various signals or marks that make up the epigenome, a key component in gene regulation. The scientists employed the algorithms used to analyse the influence and popularity of websites, such as Wikipedia or social networks. The results provide the basis for exploring communication between the components of the cell epigenome, which could be relevant for example in cancer and neurodegenerative diseases.

Contact: Vanessa Pombo
Centro Nacional de Investigaciones Oncológicas (CNIO)

Public Release: 28-Jan-2016
Microtubules, assemble!
Now, researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences have observed how microtubules and motor proteins assemble into macroscopic networks. Their observation provides a better understanding of cytoskeletal self-organization in general, which may in turn lead to better drug design and new materials that can mimic cellular behaviors.
National Science Foundation, National Institutes of Health, Human Frontier Science Program

Contact: Leah Burrows
Harvard John A. Paulson School of Engineering and Applied Sciences

Public Release: 28-Jan-2016
Free Radical Biology and Medicine
University of Arizona researchers identify food additive that may prevent skin cancer
Two researchers at the University of Arizona College of Pharmacy have discovered that a compound found in the natural food additive annatto prevents the formation of cancer cells and skin damage from UV radiation in mice. In the future the compound, bixin, may be valuable in the prevention and treatment of human skin cancers.
NIH/National Institute of Environmental Health Sciences, NIH/National Cancer Institute

Contact: Ginny Geib
University of Arizona, College of Pharmacy

Public Release: 28-Jan-2016
Leukemia & Lymphoma
Standard BMI inadequate for tracking obesity during leukemia therapy
An interdisciplinary research team at The Saban Research Institute of Children's Hospital Los Angeles has found that body mass index (BMI) is an inadequate method for estimating changes in body fat and obesity in children with leukemia. Investigators determined that the discrepancy between BMI and body composition was due to increases in body fat with simultaneous loss of lean muscle mass during treatment.
National Center for Advancing Translational Sciences, Leukemia and Lymphoma Society, Hyundai Hope on Wheels Foundation, Saban Research Institute

Contact: Ellin Kavanagh
Children's Hospital Los Angeles

Public Release: 28-Jan-2016
Multi-center study reveals unique subtypes of most common malignant brain cancer
An international collaborative study has revealed detailed new information about diffuse glioma, the most common type of tumor found in some 80 percent of adult brain cancer patients, raising hopes that better understanding of these disease groups may aid improved clinical outcomes.

Contact: Ron Gilmore
University of Texas M. D. Anderson Cancer Center

Public Release: 28-Jan-2016
Journal of Thoracic Oncology
In lung cancer, not all HER2 alterations are created equal
Study shows two distinct causes of HER2 activation in lung cancer: mutation of the gene and amplification of the gene. In patient samples of lung adenocarcinoma, 3 percent were found to have HER2 amplification and another 3 percent were found to have HER2 mutation. No samples were found to have both. These distinct causes of HER2 positivity imply the use of different targeted therapies to combat these related but possibly distinct diseases.

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 28-Jan-2016
JAMA Oncology
Genetic testing for childhood cancer patients can identify cause and treatment potential
Combined whole exome tumor and blood sequencing in pediatric cancer patients revealed mutations that could help explain the cause of cancer or have the potential to impact clinical cancer care in 40 percent of patients in a study led by researchers from Baylor College of Medicine and Texas Children's Cancer Center.
NIH/National Cancer Institute, NIH/National Human Genome Research Institute

Contact: Dana Benson
Baylor College of Medicine

Public Release: 28-Jan-2016
New way to identify brain tumor aggressiveness
A comprehensive analysis of the molecular characteristics of gliomas -- the most common malignant brain tumor -- explains why some patients diagnosed with slow-growing (low-grade) tumors quickly succumb to the disease while others with more aggressive (high-grade) tumors survive for many years.
National Institutes of Health

Contact: Karin Eskenazi
Columbia University Medical Center

Public Release: 28-Jan-2016
International study describes new glioma subtypes
In an international study conducted in Brazil, researchers have identified new glioma subtypes on the basis of epigenetic profile. The new findings serve to stratify glioma patients more accurately and will contribute to an enhancement of treatment protocols.
São Paulo Research Foundation

Contact: Samuel Antenor
Fundação de Amparo à Pesquisa do Estado de São Paulo

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