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Showing releases 1201-1225 out of 1422.

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Public Release: 29-Feb-2016
Nature Genetics
New genetic insights into mesothelioma
In a comprehensive genomic analysis using more than 200 mesothelioma tumors, investigators from Brigham and Women's Hospital have found previously unknown genetic alterations, including some that may be clinically actionable, as well as others that may improve diagnostics, screening and predictions about outcomes for patients. The team's results are published this week in Nature Genetics.

Contact: Haley Bridger
hbridger@partners.org
617-525-6383
Brigham and Women's Hospital

Public Release: 29-Feb-2016
Canadian Medical Association Journal
Many prostate cancer patients saved from unnecessary treatments and side effects
A new study from The Ottawa Hospital and the University of Ottawa shows that men with slow-growing prostate cancer are increasingly avoiding unnecessary and potentially harmful treatment in favor of an approach called active surveillance -- monitoring the cancer with regular tests and treating it only if it changes to a higher risk form.
The Ottawa Hospital Foundation

Contact: Amelia Buchanan
ambuchanan@ohri.ca
613-798-5555 x73687
Ottawa Hospital Research Institute

Public Release: 29-Feb-2016
Bulletin of the World Health Organization
People in world's poorest countries missing out on surgery
The volume of surgery has increased globally over the last decade but wide disparities in access to surgery persist between rich and poor countries. Only about 30 percent of the 312.9 million operations performed in 2012 were done in the 104 countries that spend less than US$400 on health care per capita per year, according to a study published today in the Bulletin of the World Health Organization.

Contact: Fiona Fleck
fleckf@who.int
0041-227-911-897
Bulletin of the World Health Organization

Public Release: 29-Feb-2016
Cancer Discovery
Immune therapy breaks down wall around pancreatic tumors for chemo to attack
In a new preclinical study in Cancer Discovery, researchers from the Abramson Cancer Center at the University of Pennsylvania have uncovered the poorly understood mechanics of how macrophages can be 're-educated' by an experimental immune therapy to help tear down the scaffolding that surrounds and protects pancreas cancer from chemotherapy.
National Institutes of Health grant, Molecular Biology and Molecular Pathology and Imaging Cores of the Penn Center for the Molecular Studies in Digestive and Liver Diseases, W.W. Smith Charitable Trust grant

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine

Public Release: 29-Feb-2016
Nature Medicine
Precision oncology could be tailor-made for metastatic prostate cancer
Metastatic prostate cancer, where better therapeutic strategies are desperately needed, appears to be tailor-made for precision oncology, according to a new study by researchers at Fred Hutchinson Cancer Research Center in Seattle. They found that a single metastasis within an individual patient can provide consistent molecular information to help guide therapy in metastatic prostate cancer.
National Institutes of Health, US Department of Defense, Fred Hutchinson Cancer Research Center/Solid Tumor Translational Research Award, Prostate Cancer Foundation

Contact: Kristen Woodward
kwoodwar@fredhutch.org
206-667-5095
Fred Hutchinson Cancer Research Center

Public Release: 29-Feb-2016
Canadian Medical Association Journal
Active surveillance of low-grade prostate cancer alternative to overtreatment
For men with low-grade prostate cancer, active surveillance -- monitoring with the option to treat if the cancer worsens -- is the most common management strategy at a regional diagnostic centre in Ottawa, Ontario, according to new research in CMAJ (Canadian Medical Association Journal).

Contact: Kim Barnhardt
kim.barnhardt@cmaj.ca
613-520-7116
Canadian Medical Association Journal

Public Release: 29-Feb-2016
Nature Communications
Study links normal stem cells to aggressive prostate cancer
A study that revealed new findings about prostate cells may point to future strategies for treating aggressive and therapy-resistant forms of prostate cancer.

Contact: Ron Gilmore
rlgilmore1@mdanderson.org
713-745-1898
University of Texas M. D. Anderson Cancer Center

Public Release: 29-Feb-2016
Nature Cell Biology
Blood vessels sprout under pressure
It is blood pressure that drives the opening of small capillaries during angiogenesis. A team of researchers led by Prof. Holger Gerhardt of the MDC observed the process for the first time and published their findings in Nature Cell Biology (Joint press release by the Berlin Institute of Health (BIH), Charité, German Center for Cardiovascular Research (DZHK) and Max Delbrück Center for Molecular Medicine (MDC)).

Contact: Josef Zens
josef.zens@mdc-berlin.de
49-309-406-2118
Max Delbrück Center for Molecular Medicine in the Helmholtz Association

Public Release: 29-Feb-2016
Nature Genetics
Breast cancer genetic variants found to alter how cells respond to oestrogen
An international study of almost 120,000 women has newly identified five genetic variants affecting risk of breast cancer, all of which are believed to influence how breast cells respond to the female sex hormone oestrogen.
European Union, Cancer Research UK, National Health and Medical Research Council of Australia, Australian National Breast Cancer Foundation

Contact: University of Cambridge
researchcommunications@admin.cam.ac.uk
44-012-233-32300
University of Cambridge

Public Release: 29-Feb-2016
Nature Biotechnology
Illuminating the broad spectrum of disease
Researchers from Broad Institute and Dana-Farber Cancer Institute have described a new method that dramatically simplifies an arduous experimental process in early drug discovery. Their method, called PRISM, uses a molecular barcoding system to test potential drug compounds on cancer and other cell lines at unprecedented scale and speed. The system allows for pooling and testing of multiple cell lines simultaneously, accelerating the search for targeted therapies and better representing the genetic diversity of disease.
National Institutes of Health, NIH/National Cancer Institute, Howard Hughes Medical Institute, Claudia Adams Barr Program in Cancer Research, American Society of Clinical Oncology, Prostate Cancer Foundation

Contact: Paul Goldsmith
paulg@broadinstitute.org
617-714-8600
Broad Institute of MIT and Harvard

Public Release: 28-Feb-2016
Biophysical Society 60th Annual Meeting
Cells in stiffer tissues are squeezed into mutating more often
When it comes to cancerous mutations, cells in soft tissues like bone marrow and the brain tend to exhibit fewer irregularities than their stiffer somatic brethren in the lungs or bone. According to researchers at the University of Pennsylvania, this isn't only due to differences between the cells' type and function, but also to the rigid forces of resistance that act on them when they move and divide.

Contact: AIP Media Line
media@aip.org
301-209-3090
Biophysical Society

Public Release: 28-Feb-2016
Cancer Cell
Two-pronged attack increases potency of new anti-cancer drugs
Walter and Eliza Hall Institute researchers have discovered that the treatment of the most deadly form of blood cancer may be improved by combining two recently developed drugs.
NHMRC, Victorian Govt, Cancer Council Victoria, Association pour la Recherche sur le Cancer (France), Peter Müller fellowship (Switzerland), German Research Foundation, Australian Cancer Research Foundation

Contact: Vanessa Solomon
solomon@wehi.edu.au
043-176-6715
Walter and Eliza Hall Institute

Public Release: 26-Feb-2016
BMJ Global Health
Study finds 36 percent increase in number of male smokers in India
The number of men smoking tobacco in India rose by more than one-third to 108 million between 1998 and 2015, according to a new study published today in the journal BMJ Global Health.

Contact: Leslie Shepherd
shepherdl@smh.ca
416-864-6094
St. Michael's Hospital

Public Release: 26-Feb-2016
Journal of NeuroOncology
Combination therapy may be better than radiotherapy alone to treat aggressive brain cancer
Radiotherapy effectively damages brain tumors but the cancer cells can repair themselves in order to live on. Now, researchers at Sidney Kimmel Cancer Center have tested a strategy that combines radiotherapy with a drug that shuts down the ability of tumor to mend themselves.
Novartis

Contact: Colleen Cordaro
colleen.cordaro@jefferson.edu
215-955-2238
Thomas Jefferson University

Public Release: 26-Feb-2016
Immunity
Immune cell 'switch' discovery raises hopes in cancer fight
Walter and Eliza Hall Institute researchers have discovered the mechanism that drives specialised immune cells that detect and kill cancer cells in the body, offering scientists a new way to develop potential drug targets and cancer treatments.
Australian National Health and Medical Research Council, The Menzies Foundation, Victorian Government Operational Infrastructure Support Scheme

Contact: Arunee Wilson
wilson.a@wehi.edu.au
047-871-4757
Walter and Eliza Hall Institute

Public Release: 26-Feb-2016
Lancet Haematology
Potential association between pre-labor cesarean delivery and childhood leukemia IDed
A potential correlation between pre-labor cesarean delivery (PLCD) and acute lymphoblastic leukemia (ALL) could offer new targets for cancer prevention research, according to new research from the Masonic Cancer Center, University of Minnesota.
NIH/National Cancer Institute

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center

Public Release: 26-Feb-2016
Infectious Agents and Cancer
Researchers find association between oral bacteria and esophageal cancer
University of Louisville School of Dentistry researchers have found a bacterial species responsible for gum disease, Porphyromonas gingivalis, is present in 61 percent of patients with esophageal squamous cell carcinoma.

Contact: Julie Heflin
julie.heflin@louisville.edu
502-852-7987
University of Louisville

Public Release: 26-Feb-2016
Scientific Reports
Predictive proteins: Elevated levels trigger metastatic progression of cancer cells
Researchers at University of California, San Diego School of Medicine and Moores Cancer Center, with colleagues in Spain and Germany, have unraveled how elevated levels of particular proteins in cancer cells trigger hyperactivity in other proteins, fueling the growth and spread of a variety of cancers.
National Institutes of Health, Burroughs Wellcome Fund, American Cancer Society, Translational and Clinical Research Award from Moores Cancer Center, Spanish Ministry of Education, Culture and Sports

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 26-Feb-2016
Human Gene Therapy
Non-integrating viral vector delivers chemotherapy-sensitizing gene to pancreatic cancer cells
A novel HIV-based lentiviral vector can introduce a gene to pancreatic tumor cells that makes them more sensitive to the chemotherapeutic drug gemcitabine, without integrating into cellular DNA. This integrase-defective lentiviral delivery system greatly reduces the risk of insertional mutagenesis and replication-competent lentivirus production, as describe in a new study published in Human Gene Therapy.

Contact: Kathryn Ryan
kryan@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 26-Feb-2016
Plastic and Reconstructive Surgery
Breast reconstruction using abdominal tissue -- Differences in outcome with four different techniques
In women undergoing breast reconstruction using their own (autologous) tissue, newer 'muscle-sparing' abdominal flaps can reduce complications while improving some aspects of quality of life, reports a study in the March issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons.

Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health

Public Release: 26-Feb-2016
New England Journal of Medicine
St. Joseph's Hospital research reveals standard treatment for ovarian cancer
Research led by a Dignity Health St. Joseph's Hospital and Medical Center physician on ovarian cancer was published in the Feb. 24 issue of New England Journal of Medicine. The research was directed by Bradley J. Monk, M.D., and researchers at 12 other medical facilities around the nation.

Contact: Carmelle Malkovich
carmelle.malkovich@dignityhealth.org
602-406-3319
St. Joseph's Hospital and Medical Center

Public Release: 26-Feb-2016
Journal of Urology
Light reflectance technique improves ability to remove prostate cancer during surgery
Researchers at UT Southwestern Medical Center have determined that light reflectance spectroscopy can differentiate between malignant and benign prostate tissue with 85 percent accuracy, a finding that may lead to real-time tissue analysis during prostate cancer surgery.

Contact: Lori Sundeen Soderbergh
lori.soderbergh@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 25-Feb-2016
Medical Care
Half of elderly colorectal cancer patients receiving value-less treatment
University of Colorado Cancer Center study shows that increased treatments, cost and side effects do little to increase survival in elderly advanced stage colorectal cancer patients.

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Anschutz Medical Campus

Public Release: 25-Feb-2016
JCI Insight
Understanding the role of human polyomaviruses in cancer
In this month's issue of JCI Insight, Yuan Chang and colleagues at the University of Pittsburgh Medical Center developed a new method to screen tumor samples for the presence of any human polyomavirus.
National Institutes of Health, NIH/National Cancer Institute, American Cancer Society

Contact: Corinne Williams
press_releases@the-jci.org
JCI Journals

Public Release: 25-Feb-2016
JCI Insight
Innate immune landscape in glioblastoma patient tumors
In this month's issue of JCI Insight, Amy Heimberger and colleagues at the University of Texas MD Anderson Cancer Center provide a comprehensive analysis of myeloid lineage immune cells in the circulation and in tumors of glioblastoma patients.
National Institutes of Health, Dr. Marnie Rose Foundation, University of Texas MD Anderson GBM Moonshot Program, Ethan Dmitrovsky Provost Funds

Contact: Corinne Willams
press_releases@the-jci.org
JCI Journals

Showing releases 1201-1225 out of 1422.

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