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Showing releases 1201-1225 out of 1376.

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Public Release: 30-Jan-2015
Nature Communications
Hot on the trail of the hepatitis-liver cancer connection
Using whole genomic sequencing, scientists from RIKEN in Japan have for the first time demonstrated the profound effect that chronic hepatitis infection and inflammation can have on the genetic mutations found in tumors of the liver, potentially paving the way to a better understanding of the mechanisms through which these chronic infections can lead to cancer.

Contact: Jens Wilkinson

Public Release: 29-Jan-2015
Developmental Cell
Identified the mechanism that controls localization of protein Rac1 in the cell nucleus
The prolonged presence of Rac1 in the nucleus leads to changes in nuclear morphology that are important in cell migration.

Contact: AInhoa Iriberri
Centro Nacional de Investigaciones Cardiovasculares

Public Release: 29-Jan-2015
New clues about a brain protein with high affinity for Valium
Valium, one of the best known antianxiety drugs, produces its calming effects by binding with a particular protein in the brain. But the drug has an almost equally strong affinity for a completely different protein. New studies revealing atomic level details of this secondary interaction might offer clues about Valium's side effects and point the way to more effective drugs.
National Institutes of Health, New York Structural Biology Center, DOE/Office of Science

Contact: Karen McNulty Walsh
DOE/Brookhaven National Laboratory

Public Release: 29-Jan-2015
American Journal of Human Genetics
Parkinson's gene linked to lung cancer
Researchers at the Medical College of Wisconsin, in collaboration with other colleagues of the Genetic Epidemiology of Lung Cancer Consortium, have identified a gene that is associated with lung cancer.

Contact: Maureen Mack
Medical College of Wisconsin

Public Release: 29-Jan-2015
PLOS Medicine
New minimally invasive test identifies patients for Barrett's esophagus screening
A new minimally invasive cell sampling device coupled with assessment of trefoil factor 3 expression can be used to identify patients with reflux symptoms who warrant endoscopy to diagnose Barrett's esophagus, according to a study published by Rebecca Fitzgerald and colleagues from the MRC Cancer Unit, UK, in this week's PLOS Medicine.
Cancer Research UK

Contact: Maya Sandler

Public Release: 29-Jan-2015
Cancer Research
New potential therapeutic strategy against a very aggressive infant bone cancer
Researchers at the Bellvitge Biomedical Research Institute, led by Oscar Martínez Tirado participated in an international study which suggests inhibition of Sirtuin1 protein as a future treatment option for metastatic Ewing sarcoma. The results of the study were published in the journal Cancer Research.

Contact: Arantxa Mena
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 29-Jan-2015
Journal of Thoracic Oncology
Testing for EGFR mutations and ALK rearrangements is cost-effective in NSCLC
Multiplexed genetic screening for epidermal growth factor receptor and anaplastic lymphoma kinase gene rearrangements and subsequent biomarker-guided treatment is cost-effective compared with standard chemotherapy treatment without any molecular testing in the metastatic non-small cell lung cancer setting in the United States.

Contact: Murry Wynes
International Association for the Study of Lung Cancer

Public Release: 29-Jan-2015
Cell Cycle
Fox Chase researchers reveal how pancreatic cancer cells sidestep chemotherapy
Research led by Timothy J. Yen, Ph.D., professor at Fox Chase Cancer Center, reveals that one reason pancreatic cancer can be so challenging to treat is because its cells have found a way to sidestep chemotherapy. They hijack the vitamin D receptor, normally associated with bone health, and re-purposed it to repair the damage caused by chemotherapy.

Contact: Diana Quattrone
Fox Chase Cancer Center

Public Release: 29-Jan-2015
Nucleic Acids Research
CNIO researchers broaden the catalogue of biological chimeras for the study of the genome
The team led by Alfonso Valencia gathers 29,000 biological chimeras from eight species, including humans, mice and yeast. The catalog is a very valuable source of information for cancer research, and it could reveal new markers and potential targets for the development of new cancer drugs.

Contact: Nuria Noriega
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 28-Jan-2015
Schoolgirl comment points to antibiotics as new cancer treatments
A way to eradicate cancer stem cells, using the side-effects of commonly used antibiotics, has been discovered by a University of Manchester researcher following a conversation with his young daughter.
Breast Cancer Breakthrough

Contact: Jamie Brown
University of Manchester

Public Release: 28-Jan-2015
NIH-funded study uncovers molecular alterations in head and neck cancers
A new study shows genomic differences in head and neck cancers caused by infection with the human papillomavirus. In addition, researchers have uncovered new smoking-related cancer subtypes and potential new drug targets, and found numerous genomic similarities with other cancer types. Together, this study's findings may provide detailed explanations of how HPV infection and smoking play roles in head and neck cancer risk and disease development, and offer potential diagnostic and treatment directions.
National Institutes of Health

Contact: Steven Benowitz
NIH/National Human Genome Research Institute

Public Release: 28-Jan-2015
Earlier menopause linked to everyday chemical exposures
Women whose bodies have high levels of chemicals found in plastics, personal-care products, common household items and the environment experience menopause two to four years earlier than women with lower levels of these chemicals, according to a new study at Washington University School of Medicine in St. Louis. The findings are reported online Jan. 28 in the journal PLOS ONE.
National Institutes of Health

Contact: Diane Duke Williams
Washington University School of Medicine

Public Release: 28-Jan-2015
Epigenetic drug boosts chemotherapy's efficacy in some lung cancers
An existing drug may help some patients with non-small-cell lung cancer whose tumors have become resistant to chemotherapy, finds a study from Boston Children's Hospital and the Dana-Farber Cancer Institute. The findings, in human cancer cells and in mice, suggest a window of vulnerability in NSCLC, the leading cause of cancer-related deaths worldwide. The work was published online today by the journal Nature.
Veterans of Foreign Wars, American Cancer Society, Boston University, National Institutes of Health

Contact: Irene Sege
Boston Children's Hospital

Public Release: 28-Jan-2015
Proceedings of the National Academy of Sciences
Game theory explains social interactions of cancer cells
Researchers at the University of Basel and the University of East Anglia were able to predict the interactions of cancer cells using game theory. Their results have been published by the scientific journal PNAS.

Contact: Reto Caluori
University of Basel

Public Release: 28-Jan-2015
A cancer diagnosis makes diabetes patients less adherent to their prescribed diabetes drugs
Diabetes patients become less adherent to their diabetes medications following a diagnosis of cancer, concludes a new study published in Diabetologia, the journal of the European Association for the Study of Diabetes. The research is led by Marjolein Zanders, Netherlands Comprehensive Cancer Organisation, Eindhoven, the Netherlands, Jeffrey Johnson, School of Public Health, University of Alberta, Edmonton, Canada and colleagues.

Contact: Marjolein Zanders

Public Release: 28-Jan-2015
Lancet Oncology
Some older cancer patients can avoid radiotherapy, study finds
Some older women with breast cancer could safely avoid radiotherapy, without harming their chances of survival, a study has shown.
Chief Scientist Office

Contact: Anna Borthwick
University of Edinburgh

Public Release: 28-Jan-2015
Journal of the American College of Radiology
California breast density law slow to have an impact
Ten months after California legislators enacted a controversial law mandating that radiologists notify women if they have dense breast tissue, UC Davis researchers have found that half of primary care physicians are still unfamiliar with the law and many don't feel comfortable answering breast density-related questions from patients.

Contact: Dorsey Griffith
University of California - Davis Health System

Public Release: 28-Jan-2015
PLOS Computational Biology
Dartmouth investigators conduct systematic testing of deimmunized biotherapeutic agents
By establishing protein design algorithms that simultaneously optimize drug candidates for both decreased immunogenic epitope content and high level stability and activity, researchers have established a novel testing platform. Published in PLOS Computational Biology, the paper, titled, 'Mapping the Pareto Optimal Design Space for a Functionally Deimmunized Biotherapeutic Candidate,' guides biotechnologists toward protein designs that function appropriately using sophisticated design algorithms.
National Institutes of Health

Contact: Kirk Cassels
The Geisel School of Medicine at Dartmouth

Public Release: 28-Jan-2015
Molecular Nutrition and Food Research
Green tea ingredient may target protein to kill oral cancer cells
A compound found in green tea may trigger a cycle that kills oral cancer cells while leaving healthy cells alone, according to Penn State food scientists. The research could lead to treatments for oral cancer, as well as other types of cancer.
American Institute for Cancer Research

Contact: Matt Swayne
Penn State

Public Release: 28-Jan-2015
Nature Communications
New method for identifying most aggressive childhood cancers
A research group at Lund University in Sweden has found a new way to identify the most malignant tumors in children. The method involves studying genetic 'micro-variation,' rather than the presence of individual mutations.

Contact: David Gisselsson Nord
Lund University

Public Release: 28-Jan-2015
UNC researcher co-leads effort to map genomic changes in head and neck cancer
A study co-led by a UNC Lineberger Comprehensive Cancer Center researcher has identified genomic changes in head and neck cancers linked to the sexually transmitted disease HPV -- the latest finding of a collaborative scientific effort designed to map out the genomic changes driving cancer.
NIH/National Cancer Institute, NIH/National Human Genome Research Institute

Contact: Laura Oleniacz
University of North Carolina Health Care

Public Release: 28-Jan-2015
Large study catalogs genetic culprits in head and neck cancers
Scientists publish the first comprehensive catalog of genetic mutations and other abnormal changes found in 279 cancers of the head and neck, identifying several broken molecular pathways that might be targeted by existing and future cancer drugs.
National Institutes of Health

Contact: Teresa Herbert
Dana-Farber Cancer Institute

Public Release: 28-Jan-2015
Cancer Research
Moffitt researchers discover protein pathway involved in lung cancer metastasis
Smoking is the leading cause of lung cancer, and it is estimated that more than 159,000 people in the United States died from the disease last year. Most of these deaths were because the cancer had spread to other organ sites. Following their recent discovery of a protein pathway, Moffitt Cancer Center researchers are one step closer to understanding how lung cancer cells metastasize.
NIH/National Cancer Institute

Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 27-Jan-2015
Journal of Biological Chemistry
Drug combo suppresses growth of late-stage prostate cancer tumors
Low doses of metformin, a widely used diabetes medication, and a gene inhibitor known as BI2536 can successfully halt the growth of late-stage prostate cancer tumors, a Purdue University study finds.
National Institutes of Health, National Science Foundation, American Cancer Society, China Scholarship Council

Contact: Natalie van Hoose
Purdue University

Public Release: 27-Jan-2015
Cell mechanism discovered that may cause pancreatic cancer
Researchers at Huntsman Cancer Institute at the University of Utah have found that defects in how cells are squeezed out of overcrowded tissue to die, a process called extrusion, may be a mechanism by which pancreatic cancer begins. From these findings, they may have identified an effective way to reverse the defective extrusion's effects without destroying normal tissues nearby. The results were published in the latest edition of the journal eLife.
National Institutes of Health

Contact: Linda Aagard
University of Utah Health Sciences

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