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Public Release: 31-Aug-2015
Nature Methods
DNA-guided 3-D printing of human tissue is unveiled
UCSF researchers developed a technique to build tiny models of human tissues, called organoids, more precisely than ever before using a process that turns human cells into a biological equivalent of LEGO bricks. These mini-tissues in a dish can be used to study how particular structural features of tissue affect normal growth or go awry in cancer; for therapeutic drug screening and to help teach researchers how to grow whole human organs.
The Department of Defense Breast Cancer Research Program, the National Institutes of Health, the Sidney Kimmel Foundation, the UCSF Program in Breakthrough Biomedical Research

Contact: Nicholas Weiler
University of California - San Francisco

Public Release: 31-Aug-2015
Journal of Cell Biology
Inducing metabolic catastrophe in cancer cells
Researchers at Harvard Medical School describe a way to force cancer cells to destroy a key metabolic enzyme they need to survive.
Harvard Accelerator Fund, Ludwig Center at Harvard, Chinese Academy of Sciences, Swedish Research Council, Swedish Society for Medical Research, NIH/Bational Heart, Lung, and Blood Institute, and others

Contact: Rita Sullivan King
Rockefeller University Press

Public Release: 31-Aug-2015
Nature Medicine
'Eat me' signal whets appetites for tumor-devouring dendritic cells
The therapeutic effect of CD47 blockade as a cancer treatment relies more on dendritic cells than macrophages. Anti-CD47-mediated tumor rejection will require both innate and adaptive responses.
National Institutes of Health, Chinese Academy of Sciences

Contact: John Easton
University of Chicago Medical Center

Public Release: 31-Aug-2015
Nature Cell Biology
CNIO scientists propose attacking bioenergetic metabolism to improve anti-cancer therapies
A new study by the Spanish National Cancer Research Centre has now proven that blocking glycolysis -- the molecular mechanism that makes it possible to extract energy from glucose -- is especially damaging to the division of cancer cells and that specifically acting on this energy-based peculiarity could be effective in treating cancer in combination with chemotherapeutic agents such as taxol.

Contact: Nuria Noriega
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 28-Aug-2015
Cancer Prevention Research
Moffitt makes important steps toward developing a blood test to catch pancreatic cancer early
According to a new 'proof of principle' study published in Aug. 27 issue of Cancer Prevention Research, Moffitt Cancer Center researchers hope to improve pancreatic cancer survival rates by identifying markers in the blood that can pinpoint patients with premalignant pancreatic lesions called intraductal papillary mucinous neoplasms.
American Cancer Society, NIH/National Cancer Institute

Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 28-Aug-2015
The alien within: Fetal cells influence maternal health during pregnancy (and long after)
Dramatic research has shown that during pregnancy, cells of the fetus often migrate through the placenta, taking up residence in many areas of the mother's body, where their influence may benefit or undermine maternal health.

Contact: Joe Caspermeyer
Arizona State University

Public Release: 28-Aug-2015
Researchers discover new mechanism in adrenal gland tumors
Scientists at the Helmholtz Zentrum München have elucidated a mechanism that is responsible for the development of adrenal gland tumors. They discovered that the BMP7 protein plays a key role in this process and that it could be a possible target for future treatments. The results have been published in the journal 'Oncotarget'.
Wilhelm Sander Stiftung, Deutsche Krebshilfe, Seventh Framework Programme

Contact: Natalia Pellegata
Helmholtz Zentrum München - German Research Center for Environmental Health

Public Release: 28-Aug-2015
Advanced Materials
New synthetic tumor environments make cancer research more realistic
Tumors are notoriously difficult to study in their natural habitat -- body tissues -- but a new synthetic tissue environment may give cancer researchers the next-best look at tumor growth and behavior. University of Illinois researchers have developed a new technique to create a cell habitat of hydrogels which can realistically and quickly recreate microenvironments found across biology.
National Science Foundation, American Cancer Society

Contact: Liz Ahlberg
University of Illinois at Urbana-Champaign

Public Release: 27-Aug-2015
Journal of Molecular Diagnostics
New strategy improves detection of genetic mutations in hereditary colorectal cancer
The role that PMS2 genetic mutations play in Lynch syndrome has been underestimated in part due to technological limitations. A new study in the Journal of Molecular Diagnostics describes a multi-method strategy to overcome existing technological limitations by more accurately identifying PMS2 gene mutations, which will improve diagnosis and support appropriate genetic counseling and medical management.

Contact: Eileen Leahy
Elsevier Health Sciences

Public Release: 27-Aug-2015
The DNA damage response goes viral: A way in for new cancer treatments
Salk researchers show how DNA repair proteins sound the alarm to threats, pointing to a novel cancer therapy.

Contact: Salk Communications
Salk Institute

Public Release: 27-Aug-2015
JAMA Oncology
Researchers develop framework for value-based pricing of cancer drugs
At a time when cancer drug prices are rising rapidly, an innovative new study provides the framework for establishing value-based pricing for all new oncology drugs entering the marketplace.

Contact: Judy Fortin
Emory Health Sciences

Public Release: 27-Aug-2015
Journal of Molecular Diagnostics
CanDL database shines light on clinically important cancer gene mutations
To help molecular pathologists, laboratory directors, bioinformaticians and oncologists identify key mutations that drive tumor growth in tissues obtained during cancer clinical studies, researchers at the Ohio State University Comprehensive Cancer Center -- James Cancer Hospital and Solove Research Institute have designed an online database called the Cancer Driver Log, or CanDL.
Pelotonia, Prostate Cancer Foundation, American Cancer Society, NIH/National Human Genome Research Institute

Contact: Darrell E. Ward
Ohio State University Wexner Medical Center

Public Release: 27-Aug-2015
JAMA Oncology
21-gene recurrence score and receipt of chemotherapy in patients with breast cancer
Use of the 21-gene recurrence test score was associated with lower chemotherapy use in high-risk patients and greater use of chemotherapy in low-risk patients compared with not using the test among a large group of Medicare beneficiaries, according to an article published online by JAMA Oncology.

Contact: Sarah Avery
The JAMA Network Journals

Public Release: 27-Aug-2015
Researchers mimic viral infection in colon cancer stem cells
Researchers targeting colorectal cancer stem cells -- the root cause of disease, resistance to treatment and relapse -- have discovered a mechanism to mimic a virus and potentially trigger an immune response to fight the cancer like an infection.
Cancer Research Society, Stand Up To Cancer (Epigenetics Dream Team), The Princess Margaret Cancer Foundation

Contact: Jane Finlayson
University Health Network

Public Release: 27-Aug-2015
Scientists reveal cellular clockwork underlying inflammation
Researchers at the Virginia Bioinformatics Institute at Virginia Tech have uncovered key cellular functions that help regulate inflammation -- a discovery that could have important implications for the treatment of allergies, heart disease, and certain forms of cancer. The discovery, to be published in the Oct. 6 issue of the journal Structure, explains how two particular proteins, Tollip and Tom1, work together to contribute to the turnover of cell-surface receptor proteins that trigger inflammation.

Contact: John Pastor
Virginia Tech

Public Release: 27-Aug-2015
Exploding the drug deadlock: Repurposing nitroglycerin for anti-cancer treatments
In the latest study in ecancermedicalscience, researchers find that nitroglycerin is the latest in a series of medicines that could be repurposed to treat cancer. In particular, it targets tumor hypoxia -- which could make anti-cancer drugs even more effective.

Contact: Audrey Nailor

Public Release: 27-Aug-2015
Cell Host & Microbe
Scientists identify possible key in virus, cancer research
Fanxiu Zhu, the FSU Margaret and Mary Pfeiffer Endowed Professor for Cancer Research, and his team uncovered a viral protein in the cell that inhibits the major DNA sensor and thus the body's response to viral infection, suggesting that this cellular pathway could be manipulated to help a person fight infection, cancer or autoimmune diseases.

Contact: Kathleen Haughney
Florida State University

Public Release: 27-Aug-2015
PLOS Genetics
An ounce of prevention: Research advances on 'scourge' of transplant wards
The fungus Cryptococcus causes meningitis, a brain disease that kills about 1 million people each year. It's difficult to treat because fungi are genetically quite similar to humans, so compounds that affect fungi tend to have toxic side effects for patients. Now, researchers at the University of Wisconsin-Madison have identified 18 proteins that play a role in spore formation and germination.

Contact: Christina Hull
University of Wisconsin-Madison

Public Release: 27-Aug-2015
Researchers thwart cancer cells by triggering 'virus alert'
Working with human cancer cell lines and mice, researchers at the Johns Hopkins Kimmel Cancer Center and elsewhere have found a way to trigger a type of immune system 'virus alert' that may one day boost cancer patients' response to immunotherapy drugs. An increasingly promising focus of cancer research, the drugs are designed to disarm cancer cells' ability to avoid detection and destruction by the immune system.
NIH/National Cancer Institute, Stand Up To Cancer Epigenetic Dream Team, Hodson Trust, Samuel Waxman Cancer Research Foundation, Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, DOD/Teal Award, Pershing Square Sohn Cancer Research Alliance

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 27-Aug-2015
Nature Communications
A CNIO team finds the way to generate potentially safer stem cells in the laboratory
A finding reveals why the transformation process of differentiated cells into stem cells results in significant damage to the DNA. Researchers have managed to rectify this damage using a simple modification to the culture medium, which produces potentially safer stem cells for use in regenerative medicine. The paper has been published in the journal Nature Communications.

Contact: Nuria Noriega
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 27-Aug-2015
Nature Genetics
A new virus in liver cancer
More than a cause of a simple infection, viruses are often involved in the development of serious diseases. Such is the case with liver cancer, which often develops in an organ that has been weakened by hepatitis B or C virus. Researchers at Inserm, the Paris Public Hospitals, Paris Descartes University, Paris 13 University, and Paris Diderot University have just identified the role of a new virus, hitherto unsuspected, in the occurrence of a rare type of liver cancer.
French National Cancer Institute, French National Cancer League

Contact: Jessica Zucman-Rossi
INSERM (Institut national de la santé et de la recherche médicale)

Public Release: 27-Aug-2015
Developmental Cell
Mammary gland is shaped by adaptive immune system during development
UCSF researchers have discovered that the adaptive immune system plays an active role in guiding the normal development of mammary glands, the only organs that develop predominantly after birth, beginning at puberty.

Contact: Pete Farley
University of California - San Francisco

Public Release: 27-Aug-2015
Future Science OA
Future Science OA explores current research into protein misfolding diseases
Future Science Group today announced the publication of a special issue in Future Science OA, covering the rapidly evolving field of protein misfolding diseases.

Contact: Leela Ripton
Future Science Group

Public Release: 26-Aug-2015
Journal of Nutritional Biochemistry
Colorful potatoes may pack powerful cancer prevention punch
Compounds found in purple potatoes may help kill colon cancer stem cells and limit the spread of the cancer, according to a team of researchers.
US Department of Agriculture

Contact: Matt Swayne
Penn State

Public Release: 26-Aug-2015
Science Translational Medicine
Stiffer breast tissue in obese women promotes tumors
Women who are obese have a higher risk and a worse prognosis for breast cancer, but the reasons why remain unclear. A Cornell study published this month in Science Translational Medicine explains how obesity changes the consistency of breast tissue in ways that are similar to tumors, thereby promoting disease.
National Institutes of Health, National Science Foundation, Breast Cancer Research Foundation, Weill Cornell Medical College/Botwinick-Wolfensohn Foundation

Contact: Melissa Osgood
Cornell University

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