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Public Release: 10-Oct-2014
Cancer Epidemiology, Biomarkers & Prevention
Hormone loss could be involved in colon cancer
Like diabetes, colon cancer may be caused in part by the loss of one hormone, suggesting hormone replacement therapy could stall cancer formation.

Contact: Edyta Zielinska
Thomas Jefferson University

Public Release: 10-Oct-2014
Cancer Epidemiology, Biomarkers & Prevention
Elevated cholesterol and triglycerides may increase the risk for prostate cancer recurrence
Higher levels of total cholesterol and triglycerides, two types of fat, in the blood of men who underwent surgery for prostate cancer, were associated with increased risk for disease recurrence, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
National Institutes of Health

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 9-Oct-2014
New computational approach finds gene that drives aggressive brain cancer
Using an innovative algorithm that analyzes gene regulatory and signaling networks, Columbia University Medical Center researchers have found that loss of a gene called KLHL9 is the driving force behind the most aggressive form of glioblastoma, the most common form of brain cancer.
NIH/National Cancer Institute, National Institutes of Health

Contact: Lucky Tran
Columbia University Medical Center

Public Release: 9-Oct-2014
Special chromosomal structures control key genes
Scientists have long theorized that the way in which the roughly three meters of DNA in a human cell is packaged to fit within a nuclear space just six microns wide, affects gene expression. Now, Whitehead Institute researchers present the first evidence that DNA structure does indeed have such effects -- in this case finding a link between chromosome structure and the expression and repression of key genes.
National Institutes of Health, Austrian Science Fund, and Netherlands Organization for Scientific Research

Contact: Nicole Giese Rura
Whitehead Institute for Biomedical Research

Public Release: 9-Oct-2014
Researchers reveal lung cancer can stay hidden for over 20 years
Cancer Research UK scientists have discovered that lung cancers can lie dormant for over 20 years before suddenly turning into an aggressive form of the disease.
Cancer Research UK, Rosetrees Trust

Contact: Simon Shears
Cancer Research UK

Public Release: 9-Oct-2014
Nature Communications
Nanoparticles get a magnetic handle
Glowing nanoparticles can be manipulated using magnetic fields.

Contact: Andrew Carleen
Massachusetts Institute of Technology

Public Release: 9-Oct-2014
BMC Medicine
Bowel cancer risk reduced by adopting multiple healthy behaviors
Adoption of a combination of five key healthy behaviors is associated with a reduction in the risk of developing bowel cancer. Researchers from the German Institute of Human Nutrition Potsdam-Rehbruecke quantified the impact of combined multiple healthy lifestyle behaviors on the risk of developing bowel cancer, and found that this impact is stronger in men than in women.

Contact: Shane Canning
BioMed Central

Public Release: 9-Oct-2014
Journal of Molecular Diagnostics
Researchers find RNA molecules in urine and tissue that detect prostate cancer
Researchers at Sanford-Burnham Medical Research Institute have identified a set of RNA molecules that are detectable in tissue samples and urine of prostate cancer patients but not in normal healthy individuals. The study sets the stage for the development of more sensitive and specific noninvasive tests for prostate cancer than those currently available, which could result in fewer unnecessary prostate biopsies with less treatment-related morbidity, according to a new study in The Journal of Molecular Diagnostics.
NIH/National Cancer Institute, International Prostate Cancer Foundation.

Contact: Eileen Leahy
Elsevier Health Sciences

Public Release: 9-Oct-2014
Journal of Biological Chemistry
Advanced X-ray, neutron beam imaging reveal workings of powerful biochemical switch PKA
A University of Utah-led study using X-rays and neutron beams has revealed the inner workings of a master switch that regulates basic cellular functions, but that also, when mutated, contributes to cancer, cardiovascular disease and other deadly disorders.
US Department of Energy, National Institutes of Health

Contact: Phil Sahm
University of Utah Health Sciences

Public Release: 9-Oct-2014
Journal of Clinical Investigation
Unusual skin cancer linked to chronic allergy from metal orthopedic implant
In rare cases, patients with allergies to metals develop persistent skin rashes after metal devices are implanted near the skin. New research suggests these patients may be at increased risk of an unusual and aggressive form of skin cancer.
National Institutes of Health, Howard Hughes Medical Institute, American Skin Association, Dermatology Foundation

Contact: Michael C. Purdy
Washington University School of Medicine

Public Release: 9-Oct-2014
Researchers reveal genomic diversity of individual lung tumors
A study led by scientists at the University of Texas MD Anderson Cancer Center addresses the challenge of what scientists call genomic heterogeneity, the presence of many different variations that drive tumor formation, growth and progression, and likely complicate the choice and potential efficacy of therapy.
Cancer Prevention and Research Institute of Texas, University of Texas, US Department of Defense, Welch Foundation, NIH/National Cancer Institute, National Institutes of Health

Contact: Scott Merville
University of Texas M. D. Anderson Cancer Center

Public Release: 8-Oct-2014
JAMA Psychiatry
Study looks at cardiometabolic risk, schizophrenia and antipsychotic treatment
The duration of psychiatric illness and treatment for patients after first-episode schizophrenia spectrum disorders appears to be associated with being fatter and having other cardiometabolic abnormalities.

Contact: Michelle Pinto
The JAMA Network Journals

Public Release: 8-Oct-2014
PLOS Biology
Gluing chromosomes at the right place
A new study by Raquel Oliveira, from the Instituto Gulbenkian de Ciência, in collaboration with colleagues from the University of California, Santa Cruz, now shows that the dislocation of particular DNA segments perturbs proper chromosome separation. The results of this study, published now in the open access journal PLOS Biology, raise the possibility that chromosome rearrangements involving these regions, often seen in many cancers, can induce additional errors in cell division and thereby compromise genetic stability.
Marie Curie Career Integration Grant, European Union, National Institutes of Health, California Institute for Regenerative Medicine

Contact: Ines Domingues
Instituto Gulbenkian de Ciencia

Public Release: 8-Oct-2014
Breast Cancer Research
Circulating tumor cells provide genomic snapshot of breast cancer
Tumor cells isolated from the blood of patients with triple negative breast cancer reveal similar cancer-driving mutations as those detected from standard biopsy, suggesting that circulating cells could one day replace tissue biopsies.

Contact: Edyta Zielinska
Thomas Jefferson University

Public Release: 8-Oct-2014
EMBO Reports
Fruit flies reveal features of human intestinal cancer
Researchers in Spain have determined how a transcription factor known as Mirror regulates tumor-like growth in the intestines of fruit flies. The scientists believe a related system may be at work in humans during the progression of colorectal cancer due to the observation of similar genes and genetic interactions in cultured colorectal cancer cells. The results are reported in the journal EMBO Reports.

Contact: Barry Whyte

Public Release: 8-Oct-2014
EMBO Reports
Flies with colon cancer help to unravel the genetic keys to disease in humans
The scientists identify a human gene that favors the proliferation of tumor cells in early stages of colon cancer. Furthermore, the flies are useful for faster and more economic drug screening.

Contact: Sònia Armengou
Institute for Research in Biomedicine (IRB Barcelona)

Public Release: 8-Oct-2014
New England Journal of Medicine
Patient's dramatic response and resistance to cancer drug traced to unsuspected mutations
Patients with lethal thyroid cancer experienced response for 18 months on clinical trial of everolimus. Sequencing of the tumor before and after trials yielded information on why tumor responded to and eventually resisted treatment, identifying mutations that may help guide treatment of patients with cancers with similar mutations.
Next Generation Fund at the Broad Institute, Novartis Pharmaceuticals, Starr Cancer Consortium, NIH/National Cancer Institute

Contact: Teresa Herbert
Dana-Farber Cancer Institute

Public Release: 8-Oct-2014
Mortality risk of overweight and obesity similar for blacks, whites
A study from American Cancer Society researchers finds the increased risk of premature death associated with a higher body mass index is similar for African-Americans and whites.
American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 8-Oct-2014
Molecular and Cellular Biology
Discovery may lead to lower doses of chemotherapy
Many cancer cells resist chemotherapy. BYU chemists found a protein switch that activates resistance. The discovery opens the door for medications that will make tumors more sensitive to chemotherapy.

Contact: Joe Hadfield
Brigham Young University

Public Release: 8-Oct-2014
Obstetrics & Gynecology
Robotic surgery: More complications, higher expense for some conditions
For benign gynecologic conditions, robot-assisted surgery involves more complications during surgery and may be significantly more expensive than conventional laparoscopic surgery, according to a study by researchers at Columbia University Medical Center.
NIH/National Cancer Institute

Contact: Lucky Tran
Columbia University Medical Center

Public Release: 8-Oct-2014
Hepatology International
MU researchers identify epigenetic changes caused by binge drinking
Researchers at the University of Missouri School of Medicine have identified epigenetic protein changes caused by binge drinking, a discovery that could lead to treatments for alcohol-related liver diseases.

Contact: Jeff Hoelscher
University of Missouri-Columbia

Public Release: 8-Oct-2014
Journal of Neuroscience
Neuroscientists use snail research to help explain 'chemo brain'
It is estimated that as many as half of patients taking cancer drugs experience a decrease in mental sharpness. While there have been many theories, what causes 'chemo brain' has eluded scientists.
National Institutes of Health, Zilkha Family Discovery Fellowship

Contact: Robert Cahill
University of Texas Health Science Center at Houston

Public Release: 8-Oct-2014
JAMA Otolaryngology--Head & Neck Surgery
Study finds potential link between breast cancer genes and salivary gland cancer
The risk of developing cancer in a salivary gland might be higher in people with mutations in either of two genes associated with breast and ovarian cancer. Salivary gland cancer is rare, but this new study suggests it occurs 17 times more often in people with inherited mutations in genes called BRCA1 and BRCA2.
The Sandy Slomin Foundation

Contact: Darrell E. Ward
Ohio State University Wexner Medical Center

Public Release: 7-Oct-2014
Cell Metabolism
Researchers identify 'Achilles heel' in metabolic pathway that could lead to new cancer treatment
Researchers at University of Texas Southwestern Medical Center have found an 'Achilles heel' in a metabolic pathway crucial to stopping the growth of lung cancer cells.

Contact: Lori Sundeen Soderbergh
UT Southwestern Medical Center

Public Release: 7-Oct-2014
Journal of Clinical Oncology
Drug regimen enough to control immune disease after some bone marrow transplants
Johns Hopkins and other cancer researchers report that a very short course of a chemotherapy drug, called cyclophosphamide, not only can prevent a life-threatening immune response in some bone marrow transplant recipients, but also can eliminate such patients' need for the usual six months of immune suppression medicines commonly prescribed to prevent severe forms of this immune response. Patients receive cyclophosphamide for two days after their bone marrow transplant, in addition to two other chemotherapy drugs given before the transplant.
Otsuka Pharmaceutical

Contact: Vanessa Wasta
Johns Hopkins Medicine

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