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Showing releases 1226-1250 out of 1293.

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Public Release: 24-Aug-2015
Nature Cell Biology
Mayo Clinic researchers find new code that makes reprogramming of cancer cells possible
Cancer researchers dream of the day they can force tumor cells to morph back to the normal cells they once were. Now, researchers on Mayo Clinic's Florida campus have discovered a way to potentially reprogram cancer cells back to normalcy.
National Institutes of Health

Contact: Kevin Punsky
Mayo Clinic

Public Release: 24-Aug-2015
Generic heart medication shown to prolong ovarian cancer patients' survival
In a first-of-its-kind study, researchers demonstrate a benefit in overall survival among epithelial ovarian cancer patients receiving generic heart medications known as beta-blockers. Survival was shown to be greatest among those prescribed first-generation nonselective beta-blockers. According to The University of Texas MD Anderson Cancer Center investigators, the drugs block the effects of stress pathways involved in tumor growth and spread.

Contact: Laura Sussman
University of Texas M. D. Anderson Cancer Center

Public Release: 24-Aug-2015
Journal of the National Cancer Institute
Fertility concerns impact breast cancer treatment decisions
Concerns about fertility kept a third of young women with breast cancer from taking tamoxifen, despite its known benefit in reducing the risk of breast cancer coming back.
NIH/National Institute of Child Health and Human Development, Northwestern University/Medical Student Summer Research Program

Contact: Nicole Fawcett
University of Michigan Health System

Public Release: 24-Aug-2015
Heart medications that target stress may help prolong survival in women with ovarian cancer
A new analysis of patient records indicates that certain drugs taken to improve heart health may also have anti-cancer properties.

Contact: Evelyn Martinez

Public Release: 24-Aug-2015
Journal of the National Cancer Institute
Use of tamoxifen by young women is influenced by fertility concerns
The risk of breast cancer recurrence and mortality is decreased by endocrine therapy such as tamoxifen, but younger patients may decline it or discontinue treatment early if they are concerned about fertility, according to a study published Aug. 24 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
Oxford University Press USA

Public Release: 24-Aug-2015
Veterinary Immunology and Immunopathology
Compound found in red wine causes conflicting changes in dogs' immune systems
Researchers at the University of Missouri have found that resveratrol does affect the immune systems of dogs in different ways when introduced to dogs' blood.

Contact: Nathan Hurst
University of Missouri-Columbia

Public Release: 24-Aug-2015
Future Science OA
Future ScienceOA explores nitric oxide in medicine: Where are we, and where are we headed?
Future Science Group today announced the publication of a special issue in Future Science OA, covering the rapidly evolving field of nitric oxide in human medicine.

Contact: Leela Ripton
Future Science Group

Public Release: 24-Aug-2015
Annals of Internal Medicine
Long-term NSAID use may reduce CRC risk
Long-term, continuous use of low-dose aspirin and nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with decreased colorectal cancer risk. The findings of a population-based, case-control study are published in Annals of Internal Medicine.

Contact: Cara Graeff
American College of Physicians

Public Release: 24-Aug-2015
Human Gene Therapy
Optimizing effectiveness of CAR T cell therapy in lymphoma highlighted in special nordic issue
Chimeric antigen receptor T cells, which can specifically recognize and target tumor cells, have resulted in complete responses in patients with leukemia, and although equally promising for treating lymphoma, obstacles remain and individual patient responses CAR T cell therapy have varied. The main barriers to overcome in developing the next generation of CAR T cell therapy are presented in a Review article that is part of a special Nordic issue of Human Gene Therapy.

Contact: Kathryn Ryan
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 24-Aug-2015
Journal of National Cancer Institute
Blood vessel cells help tumours evade the immune system
A new study by researchers at Sweden's Karolinska Institutet is the first to suggest that cells in the tumour blood vessels contribute to a local environment that protects the cancer cells from tumour-killing immune cells.
The Swedish Cancer Foundation, Strategic Cancer Research Program and BRECT Breast Cancer Theme Centrum at Karolinska Institutet, Swedish Research Council-supported STARGET Linneus Center of Excellence

Contact: KI Press Office
Karolinska Institutet

Public Release: 24-Aug-2015
Scientists discover electrical control of cancer cell growth
The molecular switches regulating human cell growth do a great job of replacing cells that die during the course of a lifetime. But when they misfire, life-threatening cancers can occur. Research led by scientists at The University of Texas Health Science Center at Houston has revealed a new electrical mechanism that can control these switches.
Cancer Prevention & Research Institute of Texas, National Institutes of Health

Contact: Robert Cahill
University of Texas Health Science Center at Houston

Public Release: 24-Aug-2015
Nature Neuroscience
Promising class of new cancer drugs might cause memory loss in mice
New research shows that a family of cancer drugs currently tested in patient trials can induce neurological changes in mice. The findings underscore the need for more research to determine whether these compounds can enter the brain, where they potentially might cause side effects such as memory loss.

Contact: Eva Kiesler
Rockefeller University

Public Release: 24-Aug-2015
Children's hospitals shift from CT scans for common childhood health problems
A study published online Aug. 24 by the journal Pediatrics finds a significant decrease in the use of computed tomography scans at children's hospitals for 10 common childhood diagnoses including seizure, concussion, appendectomy and upper respiratory tract infection. Study authors hypothesize the decline in CT usage may be attributable in part to a growing body of evidence linking ionizing radiation from CT scans to an increased risk of cancer in patients.

Contact: Nick Miller
Cincinnati Children's Hospital Medical Center

Public Release: 24-Aug-2015
Clinical Oncology
Electronic trigger reduces delays in evaluation for cancer diagnosis
Electronic triggers designed to search for key data, developed by researchers at Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, were able to identify and reduce follow-up delays for patients being evaluated for a diagnosis of colon or prostate cancer.
Agency for Healthcare Research and Quality, Houston Veterans Affairs HSR&D Center for Innovations in Quality, Effectiveness and Safety

Contact: Julia Parsons
Baylor College of Medicine

Public Release: 21-Aug-2015
BMC Medicine
Something to chew on -- millions of lives blighted by smokeless tobacco
More than a quarter of a million people die each year from using smokeless tobacco, researchers at the University of York have concluded.
Leeds City Council, Medical Research Council

Contact: Alistair Keely
University of York

Public Release: 20-Aug-2015
Applied Materials Today
Lighting up cancer cells to identify low concentrations of diseased cells
Researchers in China have developed tiny nanocrystals that could be used in the next generation of medical imaging technologies to light up cancer cells.

Contact: Dr. Stewart Bland

Public Release: 20-Aug-2015
JAMA Oncology
Study examines breast cancer mortality after ductal carcinoma in situ diagnosis
Researchers estimate the 20-year breast cancer-specific death rate for women diagnosed with ductal carcinoma in situ to be 3.3 percent, although the death rate is higher for women diagnosed before age 35 and for black women, according to an article published online by JAMA Oncology.

Contact: Rebecca Cheung
416-323-6400 x3210
The JAMA Network Journals

Public Release: 20-Aug-2015
Environmental Science and Technology
Breastfeeding may expose infants to toxic chemicals
A widely used class of industrial chemicals linked with cancer and interference with immune function -- perfluorinated alkylate substances, or PFASs -- appears to build up in infants by 20-30 percent for each month they're breastfed, according to a new study co-authored by experts from Harvard T.H. Chan School of Public Health. It is the first study to show the extent to which PFASs are transferred to babies through breast milk, and to quantify their levels over time.
NIH/National Institute of Environmental Health Sciences, US Environmental Protection Agency, Danish Council for Strategic Research, Danish Environmental Protection Agency/DANCEA

Contact: Marge Dwyer
Harvard T.H. Chan School of Public Health

Public Release: 20-Aug-2015
JAMA Oncology
Ductal carcinoma in situ carries a higher risk of death than previously thought
Women diagnosed with ductal carcinoma in situ (DCIS) are twice as likely to die from breast cancer compared to the general US population, according to a new study led by Dr. Steven Narod.

Contact: Rebecca Cheung
416-323-6400 x3210
Women's College Hospital

Public Release: 20-Aug-2015
Carnegie Mellon-led team identifies structure of tumor-suppressing protein
An international group of researchers led by Carnegie Mellon University physicists Mathias Lösche and Frank Heinrich have established the structure of an important tumor suppressing protein, PTEN. Their findings provide new insights into how the protein regulates cell growth and how mutations in the gene that encodes the protein can lead to cancer.
Department of Commerce, National Institutes of Health, NIH/National Institute of General Medical Sciences, NIH/National Institute of Neurological Disorders and Stroke, National Science Foundation, DOE/Office of Science, and others

Contact: Jocelyn Duffy
Carnegie Mellon University

Public Release: 20-Aug-2015
New England Journal of Medicine
Memorial Sloan Kettering Cancer Center researchers publish landmark 'basket study'
Researchers from Memorial Sloan Kettering Cancer Center have announced results from the first published basket study, a new form of clinical trial design that explores responses to drugs based on the specific mutations in patients' tumors rather than where their cancer originated.

Contact: Nicole H. McNamara
Memorial Sloan Kettering Cancer Center

Public Release: 20-Aug-2015
Nature Communications
TGen study finds genes associated with improved survival for pancreatic cancer patients
A study by the Translational Genomics Research Institute and other major research institutes, found a new set of genes that can indicate improved survival after surgery for patients with pancreatic cancer. The study also showed that detection of circulating tumor DNA in the blood could provide an early indication of tumor recurrence. In conjunction with the Stand Up To Cancer Pancreatic Cancer Dream Team, the study was published in Nature Communications.

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Public Release: 20-Aug-2015
Journal of Nuclear Medicine
PET imaging detects fast-growing prostate cancer
A molecular imaging biomarker is able to detect fast-growing primary prostate cancer and distinguish it from benign prostate lesions, addressing an unmet clinical need. The new research, published in the July 2015 issue of The Journal of Nuclear Medicine, is significant for patients with suspected prostate cancer that has not been confirmed by standard biopsy.
Prostate Cancer Foundation, Radiological Society of North America Research and Education Foundation

Contact: Kimberly Brown
Society of Nuclear Medicine

Public Release: 19-Aug-2015
Breast Cancer Research
Imaging software could speed up breast cancer diagnosis
New software could speed up breast cancer diagnosis with 90 percent accuracy without the need for a specialist, according to research published in the open access journal Breast Cancer Research. This could improve breast cancer management, particularly in developing countries where pathologists are not routinely available.

Contact: Alanna Orpen
BioMed Central

Public Release: 19-Aug-2015
EMBO Molecular Medicine
Reducing resistance to chemotherapy in colorectal cancer by inhibition of PHD1
Scientists at VIB and KU Leuven have shown that blocking the PHD1 oxygen sensor hinders the activation of p53, a transcription factor that aids colorectal cancer (CRC) cells in repairing themselves and thus resisting chemotherapy. Chemotherapy resistance remains a major clinical issue in the treatment of CRC. These findings indicate that PHD1 inhibition may have valuable therapeutic potential. The study was published in the leading medical journal EMBO Molecular Medicine, which features molecular biology-driven research.

Contact: Sooike Stoops
VIB (the Flanders Institute for Biotechnology)

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