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Showing releases 1226-1250 out of 1297.

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Public Release: 4-Feb-2014
Cancer Immunology Research
Marker may predict response to ipilimumab in advanced melanoma
Among patients with advanced melanoma, presence of higher levels of the protein vascular endothelial growth factor in blood was associated with poor response to treatment with the immunotherapy ipilimumab, according to a study published in Cancer Immunology Research, a journal of the American Association for Cancer Research.
National Institutes of Health

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 4-Feb-2014
Novel technique increases detection rate in screening mammography
Digital mammography screening with new photon-counting technique offers high diagnostic performance, according to a new study.

Contact: Linda Brooks
Radiological Society of North America

Public Release: 4-Feb-2014
Mayo Clinic Proceedings
Study finds dramatic rise in skin cancer among middle-aged adults
A new Mayo Clinic study found that among middle-aged men and women, 40 to 60 years old, the overall incidence of skin cancer increased nearly eightfold between 1970 and 2009, according to a study published in the January issue of Mayo Clinic Proceedings.

Contact: Alyson Gonzalez
Mayo Clinic

Public Release: 4-Feb-2014
Lancet Oncology
Queen's University cancer specialist's drive to improve survival rates for every European citizen
Queen's University Belfast's world renowned cancer specialist, Professor Patrick Johnston, whose work has transformed cancer care in Northern Ireland, is now leading efforts to improve survival rates across Europe.

Contact: Claire O'Callaghan
Queen's University Belfast

Public Release: 4-Feb-2014
Cell Metabolism
Study reveals how cancer cells thrive in oxygen-starved tumors
A new study identifies the molecular pathway that enables cancer cells to grow in areas of a tumor where oxygen levels are low, a condition called hypoxia. The findings might offer a new strategy for inhibiting tumor growth by developing agents that reverse this hypoxia-related pathway.
NIH/National Cancer Institute

Contact: Darrell E. Ward
Ohio State University Wexner Medical Center

Public Release: 4-Feb-2014
Molecular Cancer Therapeutics
Existing medicines show promise for treating stomach and bowel cancer
Stomach and bowel cancer, two of the most common cancers worldwide, could be treated with a class of medicines that are currently used to treat a blood disorder, a Melbourne research team has discovered.
National Health and Medical Research Council, Ludwig Institute, Victorian Government

Contact: Vanessa Solomon
Walter and Eliza Hall Institute

Public Release: 4-Feb-2014
Obesity in men could dictate future colon screenings
Obesity is a known risk factor for many cancers including colon cancer, yet the reasons behind the colon cancer link have often remained unclear. A Michigan State University study is shedding more light on the topic and has shown that elevated leptin -- a fat hormone -- higher body mass index and a larger waistline in men is associated with a greater likelihood of having colorectal polyps, precancerous growths linked to colon cancer.
NIH/National Cancer Institute

Contact: Sarina Gleason
Michigan State University

Public Release: 4-Feb-2014
Journal of Clinical Investigation
Researchers discover new hormone receptors to target when treating breast cancer
The findings offer the possibility of expanding the ways patients with breast cancer are treated with hormone therapy.

Contact: Jessica M Maki
Brigham and Women's Hospital

Public Release: 4-Feb-2014
A healthy balance
The protein STAT1 is involved in defending the body against pathogens and for inhibiting tumor development. If the levels of the protein are out of balance, disease may result. Researchers at the University of Veterinary Medicine, Vienna have developed a mouse whose STAT1 levels can be modified at will, enabling the study of the involvement of STAT1 in various processes. The work has now been published in the online journal PLOS ONE.

Contact: Mathias Mueller
University of Veterinary Medicine -- Vienna

Public Release: 3-Feb-2014
Beliefs about HPV vaccine do not lead to initiation of sex or risky sexual behavior
A new study may alleviate concerns that the human papillomavirus vaccine leads to either the initiation of sex or unsafe sexual behaviors among teenage girls and young women. The Cincinnati Children's Hospital Medical Center study shows that teen girls' and young women's beliefs regarding the human papillomavirus vaccine, whether accurate or inaccurate, are not linked to subsequent sexual behaviors over the six months after vaccination.

Contact: Jim Feuer
Cincinnati Children's Hospital Medical Center

Public Release: 3-Feb-2014
Journal of Clinical Investigation
Chemical stem cell signature predicts treatment response for acute myeloid leukemia
Researchers at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center have found a chemical "signature" in blood-forming stem cells that predicts whether patients with acute myeloid leukemia will respond to chemotherapy.
Deutsche Forschungsgemeinschaft, NIH/National Cancer Institute, New York Stem Cell Foundation

Contact: Kim Newman
Albert Einstein College of Medicine

Public Release: 3-Feb-2014
Environmental Health Perspectives
Liver tumors found in mice exposed to BPA
In one of the first studies to show a significant association between BPA and cancer development, University of Michigan School of Public Health researchers have found liver tumors in mice exposed to the chemical via their mothers during gestation and nursing.
Michigan Nutrition Research Obesity Center, National Institutes of Health, National Institute of Environmental Health Sciences

Contact: Laurel Thomas Gnagey
University of Michigan

Public Release: 3-Feb-2014
Annals of Internal Medicine
Annals of Internal Medicine tip sheet for Feb. 4, 2014
The Annals of Internal Medicine has published an article about the Center for Disease Control and Prevention's Advisory Committee on Immunization Practices recommended 2014 adult immunization schedule.

Contact: Megan Hanks
American College of Physicians

Public Release: 3-Feb-2014
Experts issue 'blueprint for action' to combat shortages of life-saving drugs
A group of prominent healthcare experts including bioethicists, pharmacists, policymakers and cancer specialists have proposed concrete steps for preventing and managing a nightmare scenario that is becoming all too common: shortages of life-saving drugs.

Contact: Leah Ramsay
Johns Hopkins Medicine

Public Release: 3-Feb-2014
Journal of Clinical Investigation
JCI early table of contents for Feb. 3, 2014
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online Feb. 3, 2014, in the JCI: "Methylation signature correlates with acute myeloid leukemia survival"; "Researchers characterize a biomarker for lysosomal storage disorders"; "Angiotensin converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline"; "Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis"; "Hyaluronan digestion controls DC migration from the skin," and more.

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 3-Feb-2014
Annals of Internal Medicine
Simple, at-home test will detect most colorectal cancers
Tests that require patients to collect a single stool sample at home and then send it to a lab for analysis will detect about 79 percent of colorectal cancers, according to a new evidence review published in the Annals of Internal Medicine. The review of 19 studies examining eight different fecal immunochemical tests, know as "FITs", also finds that the tests will correctly identify about 94 percent of patients who do not have cancers of the rectum or colon.

Contact: Vincent Staupe
Kaiser Permanente

Public Release: 3-Feb-2014
Annals of Internal Medicine
Scientists call for screening mammography every 2 years for most women
Adoption of new guidelines recommending screening mammography every two years for women ages 50 to 74 would result in breast cancer screening that is equally effective, while saving the United States $4.3 billion a year in health care costs, according to a study led by University of California San Francisco.
University of California, Safeway Foundation

Contact: Elizabeth Fernandez
University of California - San Francisco

Public Release: 3-Feb-2014
Journal of Biological Chemistry
Finding a target for tumor suppression
Biochemists found a protein that is suspected as a potential tumor suppressor and found how it could block the production of the material used as scaffolding during cell division.
National Institutes of Health

Contact: Joe Hadfield
Brigham Young University

Public Release: 3-Feb-2014
Nature Immunology
Newly discovered signaling pathway could impact a variety of autoinflammatory diseases
Researchers from Virginia Commonwealth University Massey Cancer Center have discovered a new signaling pathway in sterile inflammation that could impact the treatment of diseases such as cancer, multiple sclerosis and rheumatoid arthritis. Their findings offer insight into the role that activation of interferon-regulatory factor 1, a protein that functions as a transcriptional activator of a variety of target genes, plays in the production of chemokines and the recruitment of mononuclear cells to sites of sterile inflammation.
National Institutes of Health

Contact: Alaina Schneider
Virginia Commonwealth University

Public Release: 3-Feb-2014
Cell division finding could boost understanding of cancer
New insights into how the cells in our bodies divide could improve our knowledge of a condition linked to cancer, a study suggests.
Wellcome Trust, Scottish Universities Life Sciences Alliance

Contact: Catriona Kelly
University of Edinburgh

Public Release: 3-Feb-2014
NIH study offers insight into why cancer incidence increases with age
The accumulation of age-associated changes in a biochemical process that helps control genes may be responsible for some of the increased risk of cancer seen in older people, according to a National Institutes of Health study.
NIH/National Institute of Environmental Health Sciences

Contact: Robin Arnette
NIH/National Institute of Environmental Health Sciences

Public Release: 3-Feb-2014
Gene mutation defines brain tumors that benefit from aggressive surgery
A new study has found that malignant astrocytoma patients whose tumors carry a specific genetic mutation benefit greatly from surgical removal of the largest possible amount of tumor.
Burroughs Wellcome Trust, James S. McDonnell Foundation, Texas Neurofibromatosis Foundation

Contact: Katie Marquedant
Massachusetts General Hospital

Public Release: 3-Feb-2014
Photochemical & Photobiological Sciences
Genetic function discovered that could offer new avenue to cancer therapies
Researchers have discovered a genetic function that helps one of the most important "tumor suppressor" genes to do its job and prevent cancer. Finding ways to maintain or increase the effectiveness of this gene could offer an important new avenue for human cancer therapies.
NIH/National Institute of Environmental Health Sciences

Contact: Mark Leid
Oregon State University

Public Release: 2-Feb-2014
Nature Medicine
Red alert: Body kills 'spontaneous' blood cancers on a daily basis
Immune cells undergo 'spontaneous' changes on a daily basis that could lead to cancers if not for the diligent surveillance of our immune system, Melbourne scientists have found.
Cancer Council Victoria, Leukaemia Foundation Australia

Contact: Penny Fannin
Walter and Eliza Hall Institute

Public Release: 2-Feb-2014
Nature Genetics
Split decision: Stem cell signal linked with cancer growth
Researchers at the University of California, San Diego School of Medicine have identified a protein critical to hematopoietic stem cell function and blood formation. The finding has potential as a new target for treating leukemia because cancer stem cells rely upon the same protein to regulate and sustain their growth.
National Institutes of Health, UC San Diego Moores Cancer Center

Contact: Scott LaFee
University of California - San Diego

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