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Showing releases 1226-1250 out of 1369.

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Public Release: 17-Mar-2016
JCI Insight
A molecular subtype of bladder cancer resembles breast cancer
In this month's issue of JCI Insight, a research team characterized a new subtype of muscle-invasive bladder cancer that shares molecular signatures with some forms of breast cancer.
Bladder Cancer Advocacy Network, James Family Foundation and a Partner Fund Management Bladder Cancer Research Innovation Award, University Cancer Research Fund, UNC Oncology Clinical Translational Research Training Program

Contact: Corinne Williams
JCI Journals

Public Release: 17-Mar-2016
For first time, scientists use CRISPR-Cas9 to target RNA in live cells
Scientists have long sought an efficient method for targeting RNA -- intermediary genetic material that carries the genetic code from the cell's nucleus to protein-making machinery -- in living cells. Researchers at University of California, San Diego School of Medicine have now achieved this by applying the popular DNA-editing technique CRISPR-Cas9 to RNA. The study is published March 17, 2016 in Cell.
National Institutes of Health, California Institute for Regenerative Medicine, Howard Hughes Medical Institute, National Health and Medical Research Council of Australia, National Science Foundation Graduate Research Fellowship, Alfred P. Sloan Research

Contact: Heather Buschman
University of California - San Diego

Public Release: 17-Mar-2016
Stem Cell Reports
Reprogramming bone tumors
There exist several oncogenes that drive cancer. In many cases, however, the oncogenes themselves are not sufficient and must be complemented with other mutations before cancer develops. Researchers at the Center for iPS Cell Research and Application, Kyoto University, use cell reprogramming technology to revert cancer cells to a stem cell state. The researchers show that dysfunctional differentiation in conjunction with a specific oncogene could explain the cause of certain bone cancers.
P-DIRECT, Ministry of Education, Culture, Sports, Science, and Technology of Japan, Ministry of Health, Labor, and Welfare of Japan, SICORP, Takeda Science Foundation and Naito Foundation

Contact: Peter Karagiannis
Center for iPS Cell Research and Application - Kyoto University

Public Release: 17-Mar-2016
JCI Insight
Identification of a novel tyrosine kinase inhibitor for acute myeloid leukemia
A new study in JCI Insight reports the development of a new drug that targets both resistant tumors and FLT3-independent acute myeloid leukemia.
National Institutes of Health, Leukemia and Lymphoma Society Translation Research Program, University of North Carolina Cancer Research Fund, National Cancer Institute's Experimental Therapeutics (NExT) program, L'Institut Servier

Contact: Corinne Williams
JCI Journals

Public Release: 16-Mar-2016
Cancer Discovery
Why some tumors withstand treatment
MIT researchers uncover a mechanism that allows cancer cells to evade targeted therapies.

Contact: Sarah McDonnell
Massachusetts Institute of Technology

Public Release: 16-Mar-2016
AACR Annual Meeting 2016
10-minute urine test can measure specific compounds from food consumed
Can we say goodbye to unreliable food diaries and diet recall in exchange for a urine test that will better aid researchers in figuring out what foods might help prevent cancer? Researchers have developed a method that can quickly evaluate specific food compounds in human urine. They say their method could one day replace unreliable food logs used in population studies examining the effects of diet on cancer and will also help scientists accurately identify the most beneficial anticancer foods.

Contact: Karen Teber
Georgetown University Medical Center

Public Release: 16-Mar-2016
Researchers prevent, normalize tumors using light to control cell electric signals
It is possible to prevent tumors and normalize them after they have formed by using light to control cells' electrical signals. This is the first use of optogenetics to manipulate bioelectrical signals to prevent and regress tumors induced by oncogenes. It could spark new biomedical approaches to cancer.
G. Harold and Leila Y. Mathers Charitable Foundation

Contact: Kimberly Thurler
Tufts University

Public Release: 16-Mar-2016
Chinese scientists modulate cholesterol metabolism to potentiate T-cell antitumor immunity
As key players in the immune system, T cells provide tumor surveillance and have direct antitumor effects. In their new study, Prof. XU Chenqi's group and Prof. LI Boliang's group with the Institute of Biochemistry and Cell Biology of the Shanghai Institutes for Biological Sciences, found that inhibiting cholesterol esterification can potentiate the antitumor activity of CD8+ T cells (also known as killer T cells).
National Natural Science Foundation of China, Ministry of Science and Technology of China, Chinese Academy of Sciences/Strategic Priority Research Program, and Science and Technology Commission of Shanghai

Contact: XU Chenqi
Chinese Academy of Sciences Headquarters

Public Release: 16-Mar-2016
Nature Communications
Antibody developed at Johns Hopkins slows tumor growth and metastasis in mice
Johns Hopkins scientists report they have developed an antibody against a specific cellular gateway that suppresses lung tumor cell growth and breast cancer metastasis in transplanted tumor experiments in mice, according to a new study published in the February issue of Nature Communications.
National Institutes of Health, Veterans Administration Merit Award

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 16-Mar-2016
International Journal of Radiation Oncology, Biology, Physics
Higher volume radiation facilities associated with better survival rates
In a new study led by researchers at Brigham and Women's Hospital, investigators looked at men with aggressive prostate cancer who were treated with radiation as well as the case volume of the facility at which they were treated. They found that receiving radiation at a facility that treats a high volume of prostate cancer patients with radiation was associated with improved overall survival.
Prostate Cancer Foundation, Fitz's Cancer Warriors, David and Cynthia Chapin, Scott Forbes and Gina Ventre Fund, and others

Contact: Lori Schroth
Brigham and Women's Hospital

Public Release: 16-Mar-2016
Journal of the American College of Cardiology
High coronary calcium score may signal increased risk of cancer, kidney and lung disease
A 10-year follow-up study of more than 6,000 people who underwent heart CT scans suggests that a high coronary artery calcium score puts people at greater risk not only for heart and vascular disease but also for cancer, chronic kidney disease and chronic obstructive pulmonary disease (COPD).
NIH/National Heart, Lung, and Blood Institute, National Center for Research Resources

Contact: Vanessa McMains
Johns Hopkins Medicine

Public Release: 16-Mar-2016
Journal of Thoracic Oncology
Trained technicians using CV software improved the accuracy and quality of LDCT scans
Trained technician screeners with assisted computer-aided nodule detection or computer vision screening workstations can efficiently and accurately review and triage abnormal low-dose computed topography scans for radiologist review.

Contact: Jeff Wolf
International Association for the Study of Lung Cancer

Public Release: 15-Mar-2016
Nicotine & Tobacco Research
Study finds racial differences in smoking patterns, screening
New research from the Yale School of Public Health reveals that differences in smoking habits between African Americans and whites may lead to a disparity in screening for lung cancer. The paper was published online March 15 in Nicotine & Tobacco Research.

Contact: Michael Greenwood
Yale University

Public Release: 15-Mar-2016
Nature Communications
A global increase in antioxidant defenses of the body may delay aging and its diseases
The paper, published today in the journal 'Nature Communications,' offers a new view on the role of antioxidants in health and longevity. For the first time, scientists have enhanced the global antioxidant capacity of cells, leading to a delay in aging and to an increase in longevity. Research points to the use of drugs related to vitamin B3 as a possible method to delay aging and associated diseases.

Contact: Vanessa Pombo
Centro Nacional de Investigaciones Oncológicas (CNIO)

Public Release: 15-Mar-2016
American Chemical Society 251st National Meeting & Exposition
How a pill could improve breast cancer diagnoses
The ongoing debate about breast cancer diagnostics has left many women confused -- particularly over what age they should get mammograms and who needs treatment. An issue with current methods is that they often identify lumps but cannot conclusively pinpoint which ones are cancerous. So, researchers have developed a pill that could improve imaging, lighting up only cancerous tumors. They report their work at the 251st National Meeting & Exposition of the American Chemical Society.

Contact: Michael Bernstein
American Chemical Society

Public Release: 15-Mar-2016
Journal of the National Cancer Institute
Using generic cancer drug could save many millions of dollars
With the expiration in January of the patent on Gleevec, the drug that 15 years ago changed chronic myeloid leukemia from a death sentence to a treatable illness, insurance companies and patients have the opportunity to realize huge cost savings, new Johns Hopkins Bloomberg School of Public Health research suggests.
Agency for Healthcare Research and Quality, NIH/National Cancer Institute, National Institutes of Health Building Interdisciplinary Research Careers in Women's Health K12 Program

Contact: Stephanie Desmon
Johns Hopkins University Bloomberg School of Public Health

Public Release: 15-Mar-2016
Archives of Pathology and Laboratory Medicine
Smartphones could improve skin cancer detection in developing countries
Research suggests that smartphone microscopy could enhance the detection of skin cancer in developing countries.

Contact: Robert Cahill
University of Texas Health Science Center at Houston

Public Release: 15-Mar-2016
Cancer Discovery
Paving the way for metastasis
MIT researchers find that cancer cells remodel their environment to make it easier to reach nearby blood vessels.
Ludwig Center at MIT, US Department of Defense Breast Cancer Research Program, National Institutes of Health, Howard Hughes Medical Institute, Koch Institute Frontier Research Program/Kathy and Curt Marble Cancer Research Fund

Contact: Sarah McDonnell
Massachusetts Institute of Technology

Public Release: 15-Mar-2016
Scientific Reports
Scientists discover microbiome that may be responsible for male reproductive disorders
Research shows that bacteria can be beneficial to body processes such as digestion; however, some bacteria housed in the human body may cause disease. These specialized communities of bacteria in the body are known as microbiomes. Now, researchers at the University of Missouri have discovered a microbiome in the male reproductive tract in mice that harbors harmful bacteria. In fathers, some bacteria may initiate diseases, such as prostatitis, that can result in later prostate cancer.

Contact: Jeff Sossamon
University of Missouri-Columbia

Public Release: 15-Mar-2016
Human Vaccines and Immunotherapeutics
Mismatched expectations most common reason for patients not completing HPV vaccine series
Conflicting expectations between parents and medical providers about who is responsible for scheduling follow-up appointments is resulting in a failure of young girls completing the Human Papilloma Virus vaccination series, according to a new study led by Boston Medical Center researchers.

Contact: Elissa Snook
Boston University Medical Center

Public Release: 14-Mar-2016
Cancer Cell
UT Southwestern researchers' work shines light on how to improve cancer immunotherapy
UT Southwestern Medical Center researchers today report on a strategy to make a major advance in cancer treatment even better, and a means to test and refine this new type of immunotherapy.
NIH/National Cancer Institute, Cancer Research Institute in New York, AbbVie, Chinese Academy of Sciences, Chinese Ministry of Science and Technology

Contact: Deborah Wormser
UT Southwestern Medical Center

Public Release: 14-Mar-2016
Journal of Clinical Oncology
Anticancer drug restores hearing in some patients with neurofibromatosis
In a small clinical study with an anticancer drug that halts blood vessel growth, a handful of people with neurofibromatosis type 2 (NF2) and hearing loss had restoration of hearing.
Cancer Therapy Evaluation Program, Galloway Family Foundation, NIH/ National Cancer Institute Center for Cancer Research Intramural Research Program, NIH/National Institute on Deafness and Other Communication Disorders Intramural Research Program

Contact: Vanessa McMains
Johns Hopkins Medicine

Public Release: 14-Mar-2016
Bioorganic & Medicinal Chemistry
Scientists have synthesized new molecules with anticancer and antioxidant activity
Scientists from several Moscow universities have synthesized a set of novel selenohydantoins with anticancer and antioxidant activity. Selenohydantoins are derivatives of hydantoins in which one of the oxygen atoms is replaced by selenium. It was found that drug molecules containing selenium possess anticancer activity and can be used as effective antioxidants.

Contact: Valerii Roizen
Moscow Institute of Physics and Technology

Public Release: 14-Mar-2016
Cancer-causing gene triggered by alcohol may increase breast cancer risk
A University of Houston biologist and his team have identified a cancer-causing gene triggered by alcohol that may increase one's risk of getting breast cancer. The research not only showed that alcohol enhances the actions of estrogen in driving the growth of breast cancer cells, but also revealed it diminishes the therapeutic effects of the cancer drug Tamoxifen. The findings are described in the journal PLOS ONE, published by the Public Library of Science.

Contact: Lisa Merkl
University of Houston

Public Release: 14-Mar-2016
APS March Meeting 2016
UC team's small discovery holds big promise for cancer nanotechnology
The discovery of a new nanostructure by a team of University of Cincinnati researchers promises to advance technology used in the early detection and treatment of cancerous cells.

Contact: Rachel Richardson
University of Cincinnati

Showing releases 1226-1250 out of 1369.

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