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Showing releases 1226-1248 out of 1248.

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Public Release: 3-Oct-2014
Journal of Occupational and Environmental Hygiene
New study finds lack of adherence to safe handling guidelines for administration of antineoplastic drugs
A new National Institute for Occupational Safety and Health study, published online in the Journal of Occupational and Environmental Hygiene, found that recommended safe handling practices for workers who administer antineoplastic drugs in healthcare settings are not always followed.

Contact: Nicole Racadag
American Industrial Hygiene Association

Public Release: 3-Oct-2014
Stochastic variations of migration speed between cells in clonal populations
Microfluidic tools for precision measurements of cell migration speed reveal that migratory speed of individual cells changes stochastically from parent cells to their descendants, while the average speed of the cell population remains constant through successive generations. This finding is important in the context of cancer treatment, where treatments are sought to slow down the invasion of cancer cells.
National Institutes of Health

Contact: Philly Lim
World Scientific

Public Release: 3-Oct-2014
Journal of Clinical Endocrinology and Metabolism
Experts recommend against diagnosing testosterone deficiency in women
The Endocrine Society today issued a Clinical Practice Guideline advising against the use of testosterone therapy in healthy women.
Endocrine Society

Contact: Jenni Glenn Gingery
The Endocrine Society

Public Release: 3-Oct-2014
Open Biology
New discovery in the microbiology of serious human disease
Previously undiscovered secrets of how human cells interact with a bacterium which causes a serious human disease have been revealed in new research by microbiologists at The University of Nottingham.

Contact: Emma Rayner
University of Nottingham

Public Release: 2-Oct-2014
Cancer Cell
Study indicates possible new way to treat endometrial, colon cancers
A study led by Gordon Mills, M.D., Ph.D., professor and chair of Systems Biology at the University of Texas MD Anderson Cancer Center with Lydia Cheung, Ph.D., as the first author, points to cellular mutations in the gene PIK3R1 which activate ERK and JNK, thus allowing tumor growth.

Contact: Ron Gilmore
University of Texas M. D. Anderson Cancer Center

Public Release: 2-Oct-2014
Journal of the National Cancer Institute
Osteoporosis treatment may also benefit breast cancer patients
Treatment approaches to reduce the risk of bone metastasis associated with breast cancer may be one step closer to becoming a reality. According to a study led by the MUHC, findings show that medication used to treat bone deterioration in post-menopausal women may also slow skeletal metastasis caused from breast cancer. This study, published in the JNCI, is among the first to link bisphosphonate use with improved survival in women with breast cancer.
Canadian Institutes of Health Research,Canadian Breast Cancer Research Initiative, Quebec Network for Research on Drug Use , Fonds de recherche du Québec - Santé, Susan G. Komen Foundation.

Contact: Julie Robert
514-934-1934 x71381
McGill University Health Centre

Public Release: 2-Oct-2014
Cell Reports
Stopping liver cancer in its tracks
A University of Tokyo research group has discovered that AIM (apoptosis inhibitor of macrophage), a protein that plays a preventive role in obesity progression, can also prevent tumor development in mice liver cells. This discovery may lead to a therapy for hepatocellular carcinoma, the most common type of liver cancer and the third most common cause of cancer deaths.

Contact: Ryosuke Nobukawa
University of Tokyo

Public Release: 2-Oct-2014
American Journal of Public Health
Socioeconomic factors, fashion trends linked to increase in melanoma
Researchers at New York University Langone Medical Center explored extenuating factors, such as socioeconomic and fashion trends, that may have contributed to increased incidence of melanoma over the past century.
National Cancer Institute, Live4Life Foundation

Contact: Jim Mandler
NYU Langone Medical Center / New York University School of Medicine

Public Release: 2-Oct-2014
Cancer Research
Dog's epigenome gives clues to human cancer
This week the team led by Manel Esteller, director of the Program for Epigenetics and Cancer Biology at IDIBELL, has characterized the dog's epigenome and transferred the results to human cancer to understand the changes in appearance of tumors. The finding is published this week in the journal Cancer Research.
European Research Council, Cellex Foundations, Sandra Ibarra Foundation, Spanish Government, Catalan Government

Contact: Arantxa Mena
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 2-Oct-2014
Diet affects mix of intestinal bacteria and the risk of inflammatory bone disease
Diet-induced changes in the gut's bacterial ecosystem can alter susceptibility to an autoinflammatory bone disease by modifying the immune response, St. Jude Children's Research Hospital scientists reported. The findings appeared Sept. 28 as an advanced online publication of the scientific journal Nature.
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH/National Cancer Institute

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

Public Release: 2-Oct-2014
Clinical Cancer Research
Researchers discover gene that can predict aggressive prostate cancer at diagnosis
Researchers at The University of Texas MD Anderson Cancer Center have identified a biomarker living next door to the KLK3 gene that can predict which GS7 prostate cancer patients will have a more aggressive form of cancer.

Contact: Katrina Burton
University of Texas M. D. Anderson Cancer Center

Public Release: 2-Oct-2014
Journal of Biomedical Optics
Bioinspired materials enable new health-care options, reports Journal of Biomedical Optics
The October issue of the Journal of Biomedical Optics includes a special section on biomimetic materials and their applications in areas such as disease diagnosis, monitoring, and treatment and toxin detection. The section includes several open-access articles and is published in the SPIE Digital Library.

Contact: Amy Nelson
SPIE--International Society for Optics and Photonics

Public Release: 2-Oct-2014
Developmental Cell
A discovery could prevent the development of brain tumors in children
Scientists at the IRCM in Montréal discovered a mechanism that promotes the progression of medulloblastoma, the most common brain tumor found in children. The team, led by Frédéric Charron, Ph.D., found that a protein known as Sonic Hedgehog induces DNA damage, which causes the cancer to develop. This important breakthrough will be published in the Oct. 13 issue of the prestigious scientific journal Developmental Cell. The editors also selected the article to be featured on the journal's cover.
Canadian Institutes of Health Research, Canadian Cancer Society, Cancer Research Society

Contact: Julie Langelier
Institut de recherches cliniques de Montreal

Public Release: 2-Oct-2014
Cancer Epidemiology, Biomarkers & Prevention
Washington University review identifies factors associated with childhood brain tumors
Older parents, birth defects, maternal nutrition and childhood exposure to CT scans and pesticides are increasingly being associated with brain tumors in children, according to new research from the Brown School at Washington University in St. Louis.

Contact: Neil Schoenherr
Washington University in St. Louis

Public Release: 1-Oct-2014
Neurobiology of Disease
Medical discovery first step on path to new painkillers
A major medical discovery by scientists at the University of Nottingham could lead to the development of an entirely new type of painkiller.
Wellcome Trust, Diabetes UK, British Heart Foundation, Richard Bright VEGF Research Fund

Contact: Emma Thorne
University of Nottingham

Public Release: 1-Oct-2014
Science Signaling
Eighty percent of bowel cancers halted with existing medicines
An international team of scientists has shown that more than 80 percent of bowel cancers could be treated with existing drugs. The study found that medicines called 'JAK inhibitors' halted tumor growth in bowel cancers with a genetic mutation that is present in more than 80 per cent of bowel cancers. Multiple JAK inhibitors are currently used, or are in clinical trials, for diseases including rheumatoid arthritis, psoriasis, blood cancers and myeloproliferative disorders.
Ludwig Cancer Research, Australian National Health and Medical Research Council, Cancer Council Victoria, Royal Melbourne Hospital, Victorian Government

Contact: Alan Gill
Walter and Eliza Hall Institute

Public Release: 1-Oct-2014
Cancer Research
Immunotherapy could stop resistance to radiotherapy
Treating cancers with immunotherapy and radiotherapy at the same time could stop them from becoming resistant to treatment.
Cancer Research UK, MedImmune

Contact: Simon Shears
Cancer Research UK

Public Release: 1-Oct-2014
ACS Nano
'Stealth' nanoparticles could improve cancer vaccines
Cancer vaccines have recently emerged as a promising approach for killing tumor cells before they spread. But so far, most clinical candidates haven't worked that well. Now, scientists have developed a new way to deliver vaccines that successfully stifled tumor growth when tested in laboratory mice. And the key, they report in the journal ACS Nano, is in the vaccine's unique stealthy nanoparticles.

Contact: Michael Bernstein
American Chemical Society

Public Release: 1-Oct-2014
Researchers find promise in new treatments for GBM
Glioblastma multiforme is one of the most lethal primary brain tumors, with median survival for these patients only slightly over one year. Researchers at Boston University School of Medicine, in collaboration with researchers from the City of Hope, are looking toward novel therapeutic strategies for the treatment of GBM in the form of targeted therapies against a unique receptor, the interleukin-13 receptor α chain variant 2.
Roger Williams Medical Center Brain Tumor Research Fund

Contact: Gina DiGravio
Boston University Medical Center

Public Release: 1-Oct-2014
New molecule fights oxidative stress; May lead to therapies for cancer and Alzheimer's
Breathing oxygen helps the body create energy for its cells. As a result of the breathing process, reactive molecules called 'free radicals' are produced that often cause damage to proteins and genes found in cells. This damage is known as oxidative stress. Free radicals also have been linked to cancer, Alzheimer's and Parkinson's disease. Now, investigators at the University of Missouri have discovered a molecule that treats oxidative stress.

Contact: Jeff Sossamon
University of Missouri-Columbia

Public Release: 1-Oct-2014
Journal of Pathology
UMN research pinpoints microRNA tied to colon cancer tumor growth
Researchers at the University of Minnesota have identified microRNAs that may cause colon polyps from turning cancerous. The finding could help physicians provide more specialized, and earlier, treatment before colon cancer develops. The findings are published today in The Journal of Pathology.
Department of Surgery, University of Minnesota Medical School

Contact: Caroline Marin
University of Minnesota Academic Health Center

Public Release: 1-Oct-2014
Journal of Interferon & Cytokine Research
A new target for controlling inflammation? Long non-coding RNAs fine-tune the immune system
Regulation of the human immune system's response to infection involves an elaborate network of complex signaling pathways that turn on and off multiple genes. The emerging importance of long noncoding RNAs and their ability to promote, fine-tune, and restrain the body's inflammatory response by regulating gene expression is described in a Review article in Journal of Interferon & Cytokine Research.

Contact: Kathryn Ryan
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 1-Oct-2014
Journal of Nuclear Medicine
FDG-PET/CT shows promise for breast cancer patients younger than 40
Researchers at Memorial Sloan Kettering found that PET/CT imaging of patients younger than 40 who were initially diagnosed with stage I-III breast cancer resulted in change of diagnosis. As reported in the October issue of The Journal of Nuclear Medicine, while guidelines recommend FDG-PET/CT imaging only for women with stage III breast cancer, it can also help physicians more accurately diagnose young breast cancer patients initially diagnosed with earlier stages of the disease.

Contact: Kimberly Brown
Society of Nuclear Medicine

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