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Showing releases 1226-1250 out of 1310.

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Public Release: 10-Nov-2015
Frontiers in Genetics
Is aging a disease? Scientists call for new classification of aging
In a paper recently published in Frontiers in Genetics, scientists at Insilco Medicine highlight the need for more granular and applied classification of aging in the context of the 11th World Health Organization's International Statistical Classification of Diseases and Related Health Problems (ICD-11) expected to be finalized in 2018.

Contact: Qingsong Zhu
qszhu2000@gmail.com
410-710-9674
InSilico Medicine, Inc.

Public Release: 10-Nov-2015
Annals of Rheumatic Diseases
Childhood cancer survivors at heightened risk of several autoimmune diseases
Childhood cancer survivors are at heightened risk of a wide range of autoimmune diseases, reveals research published online in the Annals of the Rheumatic Diseases.

Contact: Caroline White
CWhite@bmj.com
44-798-080-0465
BMJ

Public Release: 10-Nov-2015
Nature Communications
BIDMC researchers describe strategies to decrease immune responses in IBD
New research led by scientists at Beth Israel Deaconess Medical Center helps explain the role of an immunosuppressive pathway associated with irritable bowel disease, a condition that develops in genetically susceptible individuals when the body's immune system overreacts to intestinal tissue, luminal bacteria or both.
National Institutes of Health

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center

Public Release: 10-Nov-2015
Nature Communications
Liquid biopsy of cerebrospinal fluid for more effective policing of brain tumors
The exploitation of cerebrospinal fluid-derived circulating DNA as liquid biopsy promises a more accurate, effective and less invasive approach in unmasking the molecular characteristics of brain tumors.

Contact: Amanda Wren
awren@vhio.net
34-695-207-886
Vall d'Hebron Institute of Oncology

Public Release: 10-Nov-2015
eLife
Novel stem cell line avoids risk of introducing transplanted tumors
In a new study published Nov. 10, 2015 in the online journal eLIFE, researchers at University of California, San Diego School of Medicine describe a new 'progenitor cell' capable of unlimited expansion and differentiation into mature kidney cells, but without the risk of forming tumors.
California Institute for Regenerative Medicine, National Institutes of Health

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 10-Nov-2015
PLOS ONE
'Missing' data complicate picture of where patients choose to die
A funded study from the University of Cambridge has raised questions about the widely-held assumption that most patients at the end of their lives prefer to die at home rather than a hospice or hospital.
National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care at Cambridgeshire, Peterborough NHS Foundation Trust

Contact: Craig Brierley
craig.brierley@admin.cam.ac.uk
44-012-237-66205
University of Cambridge

Public Release: 10-Nov-2015
Alexander Silberman Institute of Life Sciences
Oncogene
Novel double dagger anti-cancer agent
Veteran cancer researcher Professor Emeritus Alexander Levitzki and other senior colleagues from Hebrew University of Jerusalem describe new potential drug-treatment research through a careful study of, and link, between colorectal cancer and melanoma. Researchers now realize that not only does the tumor need to be targeted, but also its microenvironment and the immune system.

Contact: Richard Macales
richard.machlis@mail.huji.ac.il
972-258-81641
The Hebrew University of Jerusalem

Public Release: 10-Nov-2015
Cancer Research
A treasure trove of new cancer biomarkers
Research conducted at the RIKEN Center for Life Science Technologies (CLST) in Japan and the Harry Perkins Institute of Medical Research in Australia has identified a large number of genes that are upregulated in many different types of cancer, opening the door for developing biomarker tests that could be used to detect cancers early, allowing for prompt treatment.

Contact: Jens Wilkinson
jens.wilkinson@riken.jp
81-484-621-225
RIKEN

Public Release: 9-Nov-2015
Nature Chemical Biology
John Innes Centre scientists identify 3-D structure of enzyme critical to creation of anticancer compounds in plants
In a paper published today in Nature Chemical Biology, the groups of Professor Sarah O'Connor and Dr. Dave Lawson have identified, for the first time, the 3-D structure of the enzyme iridoid synthase responsible for a very specific form of cyclization of monoterpenes which creates anticancer and antimalarial drugs.
European Research Council, Biotechnology and Biological Sciences Research Council, and others

Contact: Geraldine Platten
geraldine.platten@jic.ac.uk
01-603-450-238
John Innes Centre

Public Release: 9-Nov-2015
Nature Genetics
New genetic cause of a childhood kidney cancer discovered
Genetic mutations in a gene called REST have been shown to cause Wilms tumor, a rare kidney cancer that occurs in children.
Wellcome Trust, Rosetrees Trust

Contact: Claire Hastings
chastings@icr.ac.uk
020-715-35380
Institute of Cancer Research

Public Release: 9-Nov-2015
Nature Genetics
Molecular clocks control mutation rate in human cells
A theory that our cells have molecular clock processes ticking inside them, that damage DNA by generating mutations continuously throughout life, has just been proven. These clock-like mutational processes could ultimately be responsible for a large proportion of human cancer and contribute to human aging. Two clock-like mutational processes have been found in human cells and the rates at which the two clocks tick in different human cell types have been determined.
Wellcome Trust, Medical Research Council, Cancer Research UK

Contact: Samantha Wynne
press.office@sanger.ac.uk
44-122-349-2368
Wellcome Trust Sanger Institute

Public Release: 9-Nov-2015
JAMA Oncology
First precision medicine trial in cancer prevention identifies molecular-based chemoprevention strategy
A team of scientists, led by researchers at The University of Texas MD Anderson Cancer Center and University of California, San Diego Moores Cancer Center, report that a genetic biomarker called loss of heterozygosity or LOH is able to predict which patients with premalignant mouth lesions are at highest risk of developing oral cancer.

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center

Public Release: 9-Nov-2015
Lancet Oncology
New test for prostate cancer significantly improves prostate cancer screening
A study from Karolinska Institutet in Sweden shows that a new test for prostate cancer is better at detecting aggressive cancer than PSA. The new test, which has undergone trial in 58,818 men, discovers aggressive cancer earlier and reduces the number of false positive tests and unnecessary biopsies. The results are published in the scientific journal The Lancet Oncology.
Stockholm County Council

Contact: KI Press Office
pressinfo@ki.se
46-085-248-6077
Karolinska Institutet

Public Release: 9-Nov-2015
Nature Methods
Flipping the switch to better see cancer cells at depths
Using a high-tech imaging method, a team of biomedical engineers at the School of Engineering & Applied Science at Washington University in St. Louis was able to see individual, early-developing cancer cells deeper in tissue than ever before with the help of a novel protein from a bacterium.
National Institutes of Health, European Union, Neuroscience Blueprint Center Core

Contact: Erika Ebsworth-Goold
eebsworth-goold@wustl.edu
Washington University in St. Louis

Public Release: 9-Nov-2015
Cancer
Meat -- and how it's cooked -- may impact kidney cancer risk
A new study indicates that a meat-rich diet may increase the risk of developing kidney cancer through mechanisms related to particular cooking compounds. Also, these associations may be modified by genetic susceptibility to kidney cancer. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study illustrates how diet and genetics may interact to impact cancer risk.

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley

Public Release: 9-Nov-2015
Cancer Cell
New study describes how glucose regulation enables malignant tumor growth
A new study led by researchers at The Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute identifies a key pathway used by cancer cells to make the lipids by integrating oncogenic signaling, fuel availability and lipid synthesis to support cell division and rapid tumor growth.
National Institutes of Health, American Cancer Society Research Scholar Grant

Contact: Amanda J Harper
amanda.harper2@osumc.edu
614-685-5420
Ohio State University Wexner Medical Center

Public Release: 9-Nov-2015
Scientific Reports
NTU scientists use dead bacteria to kill colorectal cancer
Scientists from Nanyang Technological University have successfully used dead bacteria to kill colorectal cancer cells.

Contact: Lester Kok
lesterkok@ntu.edu.sg
65-679-06804
Nanyang Technological University

Public Release: 9-Nov-2015
Genome Biology
Strangled cells condense their DNA
Scientists at the Institute of Molecular Biology have been able to see, for the first time, the dramatic changes that occur in the DNA of cells that are starved of oxygen and nutrients. This starved state is typical in some of today's most common diseases, particularly heart attacks, stroke and cancer. The findings provide new insight into the damage these diseases cause and may help researchers to discover new ways of treating them.

Contact: Dr. Ralf Dahm
press@imb.de
49-613-139-21455
Johannes Gutenberg Universitaet Mainz

Public Release: 9-Nov-2015
Proceedings of the National Academy of Sciences
New technique could expand number of diseases detected by noninvasive prenatal testing
Researchers at the University of California, San Diego School of Medicine developed a method to expand the types of chromosomal abnormalities that noninvasive prenatal testing can detect. The study, published Nov. 9 by Proceedings of the National Academy of Sciences, uses a semiconductor sequencing platform to identify small chromosomal deletions or duplications, such as occur in Cri du Chat Syndrome and DiGeorge Syndrome, with a simple blood test from the expectant mother.
National Science Foundation of China

Contact: Heather Buschman
hbuschman@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 9-Nov-2015
Journal of Thoracic Oncology
Sorafenib modestly increases progression-free survival
Sorafenib, a tyrosine kinase inhibitor targeting the receptors for vascular endothelial growth factor, platelet derived growth factor, and mast/stem cell growth factor, modestly increases progression-free survival, time to progression, and disease control rate in non-small cell lung cancer patients who have relapsed or failed two or three previous treatment regimens.

Contact: Jeff Wolf
Jeff.Wolf@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Public Release: 9-Nov-2015
Proceedings of the National Academy of Sciences
Enormous genetic variation may shield tumors from treatment
The most rigorous genetic sequencing ever carried out on a single tumor reveals far greater genetic diversity among cancer cells than anticipated, more than 100 million distinct mutations within the coding regions of its genes.
National Basic Research Program of China, Research Programs of Chinese Academy of Sciences, National Science Foundation of China, National High-tech R&D Program of China

Contact: John Easton
john.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center

Public Release: 9-Nov-2015
Environmental Health
Environmental factors may contribute to the development of some childhood cancers
Environmental factors may be a contributory cause in the development of some childhood cancers, leading scientists have revealed.

Contact: Helen Rae
helen.rae@ncl.ac.uk
44-191-208-7374
Newcastle University

Public Release: 9-Nov-2015
Cancer
Increased meat consumption, especially when cooked at high temperatures, linked to elevated kidney cancer risk
Diets high in meat may lead to an increased risk of developing renal cell carcinoma (RCC) through intake of carcinogenic compounds created by certain cooking techniques, such as barbecuing and pan-frying.

Contact: Clayton R. Boldt, Ph.D.
crboldt@mdanderson.org
713-792-9518
University of Texas M. D. Anderson Cancer Center

Public Release: 9-Nov-2015
Nature
Malignant network makes brain cancer resistant
Glioblastoma is the most malignant type of brain cancer. Scientists from the German Cancer Research Center and from Heidelberg University Hospital have now reported in Nature that glioblastoma cells are connected to each other by long cellular extensions. The cancer cells use this network for communication, thus protecting themselves from damage inflicted by therapy. When the researchers blocked the network formation, the cancer cells invaded the brain less successfully, and responded better to radiation therapy.

Contact: Sibylle Kohlstädt
s.kohlstaedt@dkfz.de
German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)

Public Release: 9-Nov-2015
Proceedings of the National Academy of Sciences
Antibody targets key cancer marker; opens door to better diagnosis, therapy
University of Wisconsin-Madison researchers have created a molecular structure that attaches to a molecule on highly aggressive brain cancer and causes tumors to light up in a scanning machine. In mouse models of human brain cancer, their tag is easily seen in a PET scanner, which is commonly used to detect cancer.

Contact: Weibo Cai
wcai4@wisc.edu
608-262-1749
University of Wisconsin-Madison

Showing releases 1226-1250 out of 1310.

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