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Public Release: 29-Apr-2014
Journal of Clinical Endocrinology and Metabolism
Vitamin D may raise survival rates among cancer patients
Cancer patients who have higher levels of vitamin D when they are diagnosed tend to have better survival rates and remain in remission longer than patients who are vitamin D-deficient, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Contact: Jenni Glenn Gingery
jgingery@endocrine.org
202-971-3655
The Endocrine Society

Public Release: 29-Apr-2014
94th AATS Annual Meeting
Major lung resection safer than ever, especially at the busiest hospitals
A major new study using data from the National Cancer Data Base details the impact of annual hospital volume on 30- and 90-day mortality rates. Investigators found that major lung surgery has become progressively safer over the last few decades, although higher death rates at low-volume hospitals and an unexpected increase in mortality at 90 days compared to 30 days were observed. The study further suggests that choosing a center that performs major lung surgery regularly can have a strong impact on survival.

Contact: Nicole Baritot
press@aats.org
978-299-4520
American Association for Thoracic Surgery

Public Release: 29-Apr-2014
Genome Research
Immunogenic mutations in tumor genomes correlate with increased patient survival
Developing immunotherapies for cancer is challenging because of significant variability among tumors and diversity in human immune types. In a study published online today in Genome Research, researchers examined the largest collection of tumor samples to date to predict patient-specific tumor mutations that may activate the patient's immune system, paving the way for more successful, personalized cancer immunotherapy.
BC Cancer Foundation, Canadian Institutes of Health Research, US Department of Defense

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory

Public Release: 29-Apr-2014
94th AATS Annual Meeting
Breath analysis offers non-invasive method to detect early lung cancer
Researchers at the University of Louisville School of Medicine are using breath analysis to detect the presence of lung cancer. Preliminary data indicate that this promising noninvasive tool offers the sensitivity of PET scanning, and has almost twice the specificity of PET for distinguishing patients with benign lung disease from those with early stage cancer. Michael Bousamra II, M.D., Associate Professor, Department of Cardiovascular and Thoracic Surgery, is presenting the results of the study at the AATS 2014 Conference on Apr. 29, 2014.

Contact: Nicole Baritot
press@aats.org
978-299-4520
American Association for Thoracic Surgery

Public Release: 29-Apr-2014
94th AATS Annual Meeting
Poor QOL doesn't predict low survival in high-risk lung cancer patients undergoing surgery
High-risk operable lung cancer patients have poorer quality of life scores than the normal US population. However surgery can still be undertaken safely: Low global quality of life scores were not associated with lower survival, recurrence-free rate, or for higher risk for adverse events following sublobar resection, a major surgical procedure.

Contact: Nicole Baritot
press@aats.org
978-299-4520
American Association for Thoracic Surgery

Public Release: 28-Apr-2014
Chromatographia
Two breath compounds could be associated with larynx cancer
Researchers at the Rey Juan Carlos University and the Alcorcon Hospital (Madrid) have compared the volatile substances exhaled by eleven people with cancer of larynx, with those of another twenty healthy people. The results show that the concentrations of certain molecules, mainly ethanol and 2-butanone, are higher in individuals with carcinoma, therefore they act as potential markers of the disease.

Contact: SINC
info@agenciasinc.es
34-914-251-820
FECYT - Spanish Foundation for Science and Technology

Public Release: 28-Apr-2014
Nature Genetics
Loss of Y chromosome can explain shorter life expectancy and higher cancer risk for men
It is generally well known that men have an overall shorter life expectancy compared to women. A recent study, led by Uppsala University researchers, shows a correlation between a loss of the Y chromosome in blood cells and both a shorter life span and higher mortality from cancer in other organs.

Contact: Jan Dumanski
jan.dumanski@igp.uu.se
46-018-471-5035
Uppsala University

Public Release: 28-Apr-2014
Cancer
Receiving chemotherapy after a breast cancer diagnosis may affect a patient's employment
A new study has found that loss of paid employment after a diagnosis of early-stage breast cancer may be common and potentially related to the type of treatment patients received.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
Wiley

Public Release: 28-Apr-2014
Nature Reviews Cancer
Imaging gives clearer picture of cancer drugs' chances of success
The quest for new cancer treatments could be revolutionized by advances in technology that can visualize living cells and tissues, scientists claim.

Contact: Jen Middleton
jen.middleton@ed.ac.uk
44-131-650-6514
University of Edinburgh

Public Release: 28-Apr-2014
Cancer
Unemployment common after breast cancer treatment
Nearly one-third of breast cancer survivors who were working when they began treatment were unemployed four years later. Women who received chemotherapy were most affected, according to a new study from the University of Michigan Comprehensive Cancer Center.
NIH/National Cancer Institute, American Cancer Society

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 28-Apr-2014
Current Oncology
Breast cancer patients place huge emphasis on gene expression profiling test
Gene expression profiling tests play a critical role when women with early-stage breast cancer decide whether to have chemotherapy, but many of them do not fully understand what some of the test results mean, new research suggests.
Cancer Care Ontario, Ontario Institute for Cancer Research

Contact: Leslie Shepherd
shepherdl@smh.ca
416-864-6094
St. Michael's Hospital

Public Release: 28-Apr-2014
Pediatrics
Well-informed patients key to accepting gene-based drug dosing
A new study out of Western University led by Dr. Michael Rieder, illustrates the need for a lot more education around pharmacogenetics -- the study of how a patient's genes can affect drug reaction and dosage. Pharmacogenetics promises to optimize patient response to therapy, but this is the first study to really investigate how patients perceive this kind of genetic testing, and whether those perceptions differ when it comes to parents and their children.
Schulich School of Medicine & Dentistry, Western University

Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario

Public Release: 28-Apr-2014
European Journal of Immunology
One cell type may quash tumor vaccines
Researchers suspect that many cancer vaccines fail because the immune cells that would destroy the tumor are actively suppressed. Now, researchers at Thomas Jefferson University have found that a single cell type may be to blame for the suppression, paving the way to better cancer vaccine design.

Contact: Edyta Zielinska
edyta.zielinska@jefferson.edu
215-955-5291
Thomas Jefferson University

Public Release: 28-Apr-2014
Journal of Biological Chemistry
Researchers identify potential new strategy to treat ovarian cancer
Scientists studying cancerous tumor tissues in a laboratory believe they have identified a potential new strategy to treat ovarian cancer -- which affects around 7,000 women in the UK each year.

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester

Public Release: 28-Apr-2014
Nature
Researchers identify mechanism of cancer caused by loss of BRCA1 and BRCA2 gene function
Inherited mutations in the BRCA1 or BRCA2 tumor suppressor genes are by far the most frequent contributors of hereditary cancer risk in the human population, often causing breast or ovarian cancer in young women of child-bearing age. Now investigators at Beth Israel Deaconess Medical Center report a new mechanism by which BRCA gene loss may accelerate cancer-promoting chromosome rearrangements.
National Institutes of Health, American Cancer Society

Contact: Bonnie Prescott
bprescot@bidcm.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center

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