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Showing releases 126-150 out of 1375.

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Public Release: 13-Jul-2015
Cancer Cell
New approach to treating B-cell acute lymphoblastic leukemia shows promise
A new compound that locks a disease-related protein into an inactive position stifled the growth of an aggressive form of leukemia in laboratory and animal tests, researchers at Dana-Farber Cancer Institute and other institutions report.
Dana-Farber/Novartis Drug Discovery Program, NIH/National Cancer Institute, NIH/National Heart, Lung, and Blood Institute

Contact: Teresa M Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute

Public Release: 13-Jul-2015
Journal of Experimental Medicine
Immune cell journey has bloody consequences
Immune cells that creep across blood vessels trigger potentially fatal bleeding in platelet-deficient mice, according to a new report. If the same is true in humans, blocking the passage of these cells could prevent dangerous complications in patients undergoing transplants or chemotherapy.
Interdisciplinary Center for Clinical Research, Deutsche Forschungsgemeinschaft, Cells-in-Motion Cluster of Excellence

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

Public Release: 13-Jul-2015
Cancer Cell
New drug combo could make cancer more sensitive to chemo
Combining chemotherapy with new drugs that target a protein that helps cancer cells to withstand chemotherapy could drastically improve treatment, according to research published in Cancer Cell.
Cancer Research UK

Contact: Greg Jones
greg.jones@cancer.org.uk
44-705-026-4059
Cancer Research UK

Public Release: 13-Jul-2015
Journal of Clinical Oncology
Young adults who survive cancer hospitalized more often than the general population
Up to 20 years after people in the 20-44 age group are declared cancer-free, they still have more hospitalizations than the general public, new research has found.
Canadian Institutes of Health Research Operating Grant, Ontario Ministry of Economic Development and Innovation

Contact: Leslie Shepherd
shepherdl@smh.ca
416-864-6094
St. Michael's Hospital

Public Release: 13-Jul-2015
Cancer Cell
Lynchpin molecule for the spread of cancer found
A single molecule called DNA-PKcs may drive metastatic processes that turn cancer from a slowly growing relatively benign disease to a killer.

Contact: Edyta Zielinska
edyta.zielinska@jefferson.edu
215-955-5291
Thomas Jefferson University

Public Release: 13-Jul-2015
Nature Genetics
Skin cancer marker plays critical role in tumor growth
New research from the Johns Hopkins Bloomberg School of Public Health suggests that the protein keratin 17 -- the presence of which is used in the lab to detect and stage various types of cancers -- is not just a biomarker for the disease, but may play a critical role in tumor growth.
NIH/National Cancer Institute, NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH/National Institute of General Medical Sciences

Contact: Stephanie Desmon
sdesmon1@jhu.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health

Public Release: 13-Jul-2015
Proceedings of the National Academy of Sciences
Nutrients turn on key tumor signaling molecule, fueling resistance to cancer therapy, Ludwig Cancer Research study shows
Tumors can leverage glucose and another nutrient, acetate, to resist targeted therapies directed at specific cellular molecules, according to Ludwig Cancer Research scientists studying glioblastoma, a deadly brain cancer. The findings, published in the July 13 Proceedings of the National Academy of Sciences, demonstrate that nutrients can strongly affect the signaling molecules that drive tumors.
Ludwig Cancer Research, NIH/National Institute for Neurological Diseases and Stroke, Defeat GBM Research Collaborative, NIH/National Cancer Institute, Ben and Catherine Ivy Foundation, Ziering Family Foundation, Ichiro Kanehara Foundation, and others

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research

Public Release: 13-Jul-2015
19th International Conference on Prenatal Diagnosis and Therapy
JAMA
Certain abnormal prenatal testing results and subsequent diagnosis of maternal cancer
In preliminary research, a small number of occult (hidden) malignancies were subsequently diagnosed among pregnant women whose noninvasive prenatal testing results showed chromosomal abnormalities but the fetal karyotype was subsequently shown to be normal, according to a study appearing in JAMA. The study is being released to coincide with its presentation at the 19th International Conference on Prenatal Diagnosis and Therapy in Washington, D.C.

Contact: Jeremy Lechan
JLechan@tuftsmedicalcenter.org
617-636-0104
The JAMA Network Journals

Public Release: 13-Jul-2015
Cancer
Cancer survivors may face unique challenges when trying to adopt
A new study has found that cancer survivors' options for adoption may be limited by adoption agencies' policies.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
Wiley

Public Release: 10-Jul-2015
eLife
Cell structure discovery advances understanding of cancer development
University of Warwick researchers have discovered a cell structure which could help scientists understand why some cancers develop.
Cancer Research UK, North West Cancer Research

Contact: Nicola Jones
N.Jones.1@warwick.ac.uk
44-247-615-0868
University of Warwick

Public Release: 9-Jul-2015
The Lancet
Less intensive chemo avoids irreversible side effects in children's cancer
Children with a rare type of cancer called Wilms' tumor who are at low risk of relapsing can now be given less intensive treatment, avoiding a type of chemotherapy that can cause irreversible heart problems in later life.
Cancer Research UK

Contact: Ailsa Stevens
ailsa.stevens@cancer.org.uk
44-203-469-8309
Cancer Research UK

Public Release: 9-Jul-2015
JAMA Oncology
Aggressive cancer treatment near end of life persists despite rise in advance planning efforts
In a review of nearly 2,000 surveys with people whose loved ones died of cancer, researchers led by Johns Hopkins experts say they found a 40 percent increase over a 12-year period in the number of patients with cancer who participated in one form of advance care planning -- designating durable power of attorney privileges to a loved one -- but no corresponding impact on their rates of aggressive medical care received in the last weeks of life.
NIH/National Institute on Aging, NIH/National Cancer Institute

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 9-Jul-2015
JAMA Oncology
Studies, commentary, editorial, editor's note focus on teens, adults at end of life
A related package of articles published online by JAMA Oncology focuses on end-of-life care for teens and young adults and advance care planning for patients with cancer. The package of articles includes two original investigations, an invited commentary, an editorial, an accompanying editor's note and an author audio interview.

Contact: Irene Sege
irene.sege@childrens.harvard.edu
617-919-7379
The JAMA Network Journals

Public Release: 9-Jul-2015
PLOS ONE
UEA scientists separate medical benefits of cannabis from unwanted side effects
Scientists at the University of East Anglia have found a way to separate medical benefits of cannabis from its unwanted side effects. The research was carried out in mice, but it is hoped that the breakthrough will pave the way for safe cannabis-based therapies that do not cause alterations in mood, perception or memory. Last year the team discovered how the main psychoactive ingredient in cannabis, known as THC, reduces tumor growth in cancer patients.

Contact: Lisa Horton
press@uea.ac.uk
44-016-035-93496
University of East Anglia

Public Release: 9-Jul-2015
American Thoracic Society International Conference
New program using CT technology helping doctors better detect lung cancer
Long-time smokers and past smokers now have a more accurate way of detecting whether or not they have lung cancer thanks to a comprehensive lung cancer screening program that uses CT scan technology at Intermountain Medical Center in Salt Lake City.

Contact: Jess C. Gomez
jess.gomez@imail.org
801-507-7455
Intermountain Medical Center

Public Release: 9-Jul-2015
Cell
New technique for precise light-activated chemotherapy drugs
A new technique that uses light to activate chemotherapy drugs in specific cells shows promise as a way to improve the effectiveness of cancer therapies while preventing severe side effects, according to a study published July 9 in Cell. The approach could be used to treat a range of tumors with unprecedented precision by making existing cancer drugs sensitive to light -- an approach that requires less time and effort compared with traditional drug discovery programs.

Contact: Joseph Caputo
jcaputo@cell.com
617-335-6270
Cell Press

Public Release: 9-Jul-2015
JAMA Oncology
Two-thirds of teen and young adult cancer patients facing end of life use aggressive measures
More than two-thirds of adolescents and young adults dying of cancer utilized one or more aggressive interventions in the last month of life, according to a retrospective study published July 9 in JAMA Oncology. The findings suggest the need for more research into whether patients have been adequately supported to contemplate their end-of-life options or whether the pattern reflects their well-considered wishes.
Cancer Research Network, NIH/National Cancer Institute

Contact: Irene Sege
irene.sege@childrens.harvard.edu
617-919-3110
Dana-Farber Cancer Institute

Public Release: 9-Jul-2015
Nature Communications
Study advances potential of tumor genome sequencing and DNA-based blood tests in precision treatment
In a genome-sequencing study of pancreatic cancers and blood in 101 patients, Johns Hopkins Kimmel Cancer Center scientists say they found at least one-third of the patients' tumors have genetic mutations that may someday help guide precision therapy of their disease. Results of blood tests to detect DNA shed from tumors, they say, also predicted cancer recurrence more than half a year earlier than standard imaging methods.
American Association for Cancer Research Stand Up To Cancer-Dream Team, NIH/National Cancer Institute FasterCures, European Community's Seventh Framework Programme, Swim Across America, Dennis Troper and Susan Wojcicki

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 9-Jul-2015
Cell Reports
New genomic analysis identifies recurrent fusion genes in gastric cancers
Studying the gastric cancers of 15 Southeast Asian patients, researchers at The Jackson Laboratory, the Genome Institute of Singapore and other institutions identified five recurrent fusion genes, one of which appears to lead to cellular changes involved in acute gastritis and cancer.
The Agency for Science Technology and Research in Singapore, Translational Clinical Research Flagship Program, Singapore Gastric Cancer Consortium, Genome Institute of Singapore, National Medical Research Council of Singapore, and others

Contact: Joyce Peterson
joyce.peterson@jax.org
207-288-6058
Jackson Laboratory

Public Release: 9-Jul-2015
Cell Reports
Researchers identify critical genes responsible for brain tumor growth
After generating new brain tumor models, Cedars-Sinai scientists in the Board of Governors Regenerative Medicine Institute identified the role of a family of genes underlying tumor growth in a wide spectrum of high grade brain tumors.
Board of Governor's Regenerative Medicine Institute, Samuel Oschin Comprehensive Cancer Institute, Margaret E. Early Foundation, California Institute of Regenerative Medicine, Smidt Family Foundation, Paul and Vera Guerin Family Foundation

Contact: Cara Martinez
cara.martinez@cshs.org
310-423-7798
Cedars-Sinai Medical Center

Public Release: 9-Jul-2015
Blood
Promising drug for childhood acute leukemia -- where to next?
A new Australian study shows that a recently-developed drug, already used safely in adult leukemia clinical trials, holds great promise for some children with an aggressive form of cancer known as acute lymphoblastic leukemia.
NIH/National Cancer Institute, National Health and Medical Research Council of Australia

Contact: Alison Heather
aheather@ccia.org.au
61-434-071-326
Children's Cancer Institute Australia

Public Release: 9-Jul-2015
Nature
Researchers call for support for data in the cloud to facilitate genomics research
Today in the journal Nature prominent researchers from Canada, Europe and the US have made a powerful call to major funding agencies, asking them to commit to establishing a global genomic data commons in the cloud that could be easily accessed by authorized researchers worldwide.

Contact: Christopher Needles
christopher.needles@oicr.on.ca
416-673-8505
Ontario Institute for Cancer Research

Public Release: 9-Jul-2015
BMC Genomics
'Jumping genes' may drive esophageal cancer
Cancer Research UK scientists have found that 'jumping genes' may add to the genetic chaos behind more than three-quarters of esophageal cancer cases.

Contact: Emily Head
emily.head@cancer.org.uk
44-203-469-6189
Cancer Research UK

Public Release: 9-Jul-2015
2D Materials
Super graphene helps boost chemotherapy treatment
Silver is often used as a coating on medical equipment used for chemotherapy. The problem is that this silver coating can break down drugs. Now, researchers have found a graphene coating that will help boost the effect of chemotherapy.
Norwegian Ph.D. Network on Nanotechnology for Microsystems, Research Council of Norway

Contact: Justin Wells
justin.wells@ntnu.no
47-735-93428
Norwegian University of Science and Technology

Public Release: 8-Jul-2015
Oncogene
Disrupting cells' 'powerhouses' can lead to tumor growth, Penn study finds
A study by University of Pennsylvania researchers implicates defects in mitochondria, the energy-production centers of cells, as playing a key role in the transition from normal to cancerous.
National Institutes of Health, Harriet Ellison Woodward Trust

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania

Showing releases 126-150 out of 1375.

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