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Showing releases 126-150 out of 1316.

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Public Release: 6-Aug-2015
Journal of Biological Chemistry
Protein may trigger cancer cell's metabolism
New research shows that a modified version of the protein Hsp90 that's known to trigger death in nervous system cells may actually help cancer cells.
National Institutes of Health

Contact: Mark Schlueb
mark.schlueb@ucf.edu
407-823-0221
University of Central Florida

Public Release: 6-Aug-2015
Molecular Cell
Observing live energy production by malignant cells
To be able to function, cell mitochondria import 'fuel' using a carrier, the mitochondrial pyruvate carrier (MPC). In order to determine whether the MPC is still functional in malignant cells, scientists have just developed a biosensor to measure its live activity.

Contact: Jean-Claude Martinou
jean-claude.martinou@unige.ch
41-223-796-443
Université de Genève

Public Release: 6-Aug-2015
Molecular Cell
Scientists discover how key proteins segregate vital genetic information during mitosis
Chromosomes are responsible for carrying our genes and essentially protecting the information that helps ensure normal growth, with vital instructions being passed on by mitosis. While this copying mechanism has been well understood for decades, scientists have been unable to describe exactly how genetic information is protected and properly segregated as mitosis is happening. New research from the Wistar Institute has identified an interaction between proteins that provides a pivotal role in organizing chromosomes so that vital genetic information gets passed on safely.
G. Harold & Leila Y. Mathers Charitable Foundation, National Institutes of Health

Contact: Ben Leach
bleach@wistar.org
215-495-6800
The Wistar Institute

Public Release: 6-Aug-2015
Molecular Cell
New research tool tracks real-time DNA-protein binding in cells
Researchers have developed a new technology that precisely marks where groups of regulatory proteins called transcription factors bind DNA in the nuclei of live cells. Reporting their data Aug. 6 in the journal Molecular Cell, scientists at Cincinnati Children's Hospital Medical Center say the new technology -- called SpDamID -- could allow scientists to answer basic questions about tissue development and disease that existing technology cannot address.

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center

Public Release: 6-Aug-2015
JAMA Oncology
Hypofractionation vs. Conventional fractionation in breast cancer radiotherapy
JAMA Oncology will publish two studies, a commentary and an author audio interview examining outcomes in women with breast cancer who had breast-conserving surgery and were treated with hypofractionated radiation therapy (shorter courses of radiation treatment administered in larger daily fraction sizes) compared with longer courses of conventionally fractionated radiation therapy.

Contact: Lany Kimmons
rlkimmons@mdanderson.org
713-563-5801
The JAMA Network Journals

Public Release: 6-Aug-2015
JAMA Oncology
Shorter course of radiation improves quality of life for breast cancer patients
Women who receive a shorter course of whole breast radiation therapy for early stage disease experience less toxicity and improved quality of life compared to those who undergo a longer course of treatment, researchers report from The University of Texas MD Anderson Cancer Center.

Contact: Lany Kimmons
rlkimmons@mdanderson.org
713-563-5801
University of Texas M. D. Anderson Cancer Center

Public Release: 6-Aug-2015
Molecular Biology of the Cell
Mutant cells that can't copy DNA keep dividing when they shouldn't
Scientists have created a yeast model for studying an unusual gene mutation that is associated with cancer. Video here: https://youtu.be/e-op9p90Fy0.
National Institutes for Health

Contact: Robert Perkins
perkinsr@usc.edu
213-740-9226
University of Southern California

Public Release: 6-Aug-2015
Cancer Immunology Research
Neutrophil and cancer cell 'crosstalk' underlies oral cancer metastasis
An abnormal immune response or 'feedback loop' could very well be the underlying cause of metastases in oral cancers, according to Dr. Marco Magalhaes, Assistant Professor at the University of Toronto's Faculty of Dentistry. Magalhaes has unearthed a significant connection between the inflammatory response of a very specific form of immune cells, neutrophils, and the spread of this deadly disease.

Contact: Erin Vollick
erin.vollick@dentistry.utoronto.ca
416-979-4900 x4381
University of Toronto - Faculty of Dentistry

Public Release: 5-Aug-2015
The Annals of Thoracic Surgery
Delay in treatment, missed diagnostic testing found among lung cancer patients
Patients undergoing surgery for lung cancer may wait too long to receive treatment, and too many patients skip vital diagnostic steps that are needed to help determine the best possible treatment, according to study published in the August 2015 issue of The Annals of Thoracic Surgery.

Contact: Cassie McNulty
mcnulty@sts.org
312-202-5865
Elsevier

Public Release: 5-Aug-2015
PLOS Genetics
Penn study details powerful molecular promoter of colon cancers
Cancer researchers already know of some oncogenes and other factors that promote the development of colon cancers, but they don't yet have the full picture of how these cancers originate and spread. Now researchers have illuminated another powerful factor in this process, by unraveling an additional pathway for the origin of colon cancer.
National Institutes of Health, The Lustgarten Family, The Hansen Foundation, and National Colon Cancer Research Alliance

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 5-Aug-2015
Nature
Scientists solve structure of important protein for tumor growth
In a collaborative study between at Sanford Burnham Prebys Medical Discovery Institute and the Argonne National Laboratory, scientists have used a highly specialized X-ray crystallography technique to solve the protein structure of hypoxia-inducible factors, important regulators of a tumor's response to low oxygen.
National Institutes of Health

Contact: Patrick Bartosch
pbartosch@sbpdiscovery.org
407-745-2097
Sanford-Burnham Prebys Medical Discover Institute

Public Release: 5-Aug-2015
Oncotarget
Scientists discover cancer markers may be present early during human development
Researchers at the Virginia Bioinformatics Institute have uncovered a link between the genomes of cells originating in the neural crest and development of tumors -- a discovery that could lead to new ways to diagnose and treat cancer.

Contact: John Pastor
jdpastor@vt.edu
540-231-5646
Virginia Tech

Public Release: 5-Aug-2015
Obstetrics & Gynecology
Long-term ovarian cancer survival higher than thought
Combing data collected on thousands of California ovarian cancer patients, UC Davis researchers have determined that almost one-third survived at least 10 years after diagnosis.

Contact: Dorsey Griffith
dgriffith@ucdavis.edu
916-734-9118
University of California - Davis Health System

Public Release: 5-Aug-2015
Proceedings of the National Academy of Sciences
Cancer treatment models get real
Rice University and MD Anderson Cancer Center researchers use a custom flow perfusion bioreactor to show the value of testing cancer samples in realistic environments.
MD Anderson Cancer Center, National Institutes of Health

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University

Public Release: 5-Aug-2015
New England Journal of Medicine
Two-drug combination boosts survival in metastatic prostate cancer
Men with metastatic, hormone-sensitive prostate cancer gained more than a year of survival when they received both hormone-blocking medications and chemotherapy right after diagnosis, rather than delaying the chemo until the cancer worsened, according to a study led by Dana-Farber's Christopher Sweeney published in the New England Journal of Medicine.
Public Health Service Grants, NIH/National Cancer Institute, National Institutes of Health, and others

Contact: Teresa M Herbert
teresa_herbert@dfci.harvard.edu
617-632-5653
Dana-Farber Cancer Institute

Public Release: 5-Aug-2015
Cancer Discovery
Penn scientists identify key genetic factor that keeps moles from turning into melanoma
Moles are benign tumors found on the skin of almost every adult. Scientists have known for years that a mutation in the BRAF gene makes them start growing, but until now haven't understood why they stop. Now, researchers from the Perelman School of Medicine at the University of Pennsylvania have identified a major genetic factor that keeps moles in their usual non-cancerous, no-growth state.
National Institutes of Health, Melanoma Research Alliance, Dermatology Foundation, American Skin Association, Melanoma Research Foundation

Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-349-5964
University of Pennsylvania School of Medicine

Public Release: 4-Aug-2015
Journal of Clinical Investigation
Key protein drives 'power plants' that fuel cells in heart and other key body systems
Case Western Reserve University scientists have discovered that a protein called Kruppel-like Factor 4 (KLF4) controls mitochondria -- the 'power plants' in cells that catalyze energy production. Specifically, they determined KLF4's pivotal role through its absence -- that is, the mitochondria malfunction without enough of the protein, which in turn leads to reduced energy. The researchers' findings appear in the August edition of The Journal of Clinical Investigation.
National Institutes of Health, American Heart Association

Contact: Jeannette Spalding
Jeannette.Spalding@case.edu
216-368-3004
Case Western Reserve University

Public Release: 4-Aug-2015
British Journal of Cancer
England still struggling to close the gap in cancer survival
Cancer survival in England remains lower than countries with similar healthcare systems, according to a new Cancer Research UK funded study published in the British Journal of Cancer today.
Cancer Research UK

Contact: Stephanie McClellan
stephanie.mcclellan@cancer.org.uk
020-346-95314
Cancer Research UK

Public Release: 4-Aug-2015
Cancer Epidemiology, Biomarkers & Prevention
Exercise during teen years linked to lowered risk of cancer death later
Women who exercised during their teen years were less likely to die from cancer and all other causes during middle-age and later in life, according to a new study by investigators at Vanderbilt University Medical Center and the Shanghai Cancer Institute in China.
National Institutes of Health

Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center

Public Release: 4-Aug-2015
Nature Communications
Molecular tinkering doubles cancer drug's efficacy
Researchers at Duke University have molecularly repackaged a widely used cancer drug called paclitaxel, more than doubling its effectiveness at destroying tumors than the current gold-standard pharmaceutical, Abraxane.
National Institutes of Health

Contact: Ken Kingery
ken.kingery@duke.edu
919-660-8414
Duke University

Public Release: 3-Aug-2015
Nature Communications
Stress responder is a first responder in helping repair DNA damage and avoiding cancer
DNA damage increases the risk of cancer, and researchers have found that a protein, known to rally when cells get stressed, plays a critical, early step in its repair.
National Institutes of Health

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University

Public Release: 3-Aug-2015
New England Journal of Medicine
Irradiation of regional nodes in stage I - III breast cancer patients affects overall survival
At a median follow-up of 10.9 years, an EORTC study has shown that irradiation of regional nodes in patients with stage I, II, or III breast cancer has a marginal effect on overall survival, the primary endpoint (at 10 years, overall survival was 82.3 percent for regional irradiation versus 80.7 percent for no regional irradiation).

Contact: John Bean
john.bean@eortc.be
European Organisation for Research and Treatment of Cancer

Public Release: 3-Aug-2015
Journal of Investigative Dermatology
Veterans returning from Middle East face higher skin cancer risk
Soldiers who served in the glaring desert sunlight of Iraq and Afghanistan returned home with an increased risk of skin cancer, due not only to the desert climate, but also a lack of sun protection, Vanderbilt dermatologist Jennifer Powers, M.D., reports in a study published recently in the Journal of Investigative Dermatology.
Skin Cancer Foundation, NIH/National Center for Advancing Translational Science

Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center

Public Release: 3-Aug-2015
Technology
Scaffold-integrated microchips for end-to-end in vitro tumor cell attachment and xenograft formation
A team of researchers from Massachusetts General Hospital, Florida State University, and University of Massachusetts has developed a new microchip that can retrieve microfluidically attached cancer cells for serial analysis by integrating a 3-D hydrogel scaffold into a fluidic device. The researchers describe their approach in the forthcoming issue of the journal TECHNOLOGY.
National Institute of Health, and Shriners Hospitals for Children

Contact: Philly Lim
mllim@wspc.com
65-646-65775
World Scientific

Public Release: 3-Aug-2015
American Journal of Epidemiology
Yo-yo dieting not associated with increased cancer risk
The first comprehensive study of its kind finds weight cycling, repeated cycles of intentional weight loss followed by regain, was not associated with overall risk of cancer in men or women.
American Cancer Society

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society

Showing releases 126-150 out of 1316.

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