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Public Release: 9-Aug-2016
Trends in Cancer
Why is breast cancer common but heart cancer rare?
Malignant cancers strike certain organs, such as the colon or breast, more often than others. In an Opinion publishing Aug. 9 in Trends in Cancer, researchers propose that this vulnerability in some organs may be due to natural selection. Humans can tolerate tumors in large or paired organs more easily than in small, critical organs, such as the heart, and so the larger organs may have evolved fewer mechanisms to defend against cancerous cells.

Contact: Joseph Caputo
Cell Press

Public Release: 9-Aug-2016
Journal of Biological Chemistry
Study may lead to better breast cancer drugs
Biomedical scientists have revealed the inner workings of a group of proteins that help to switch critical genes on and off during blood-cell production, in a finding that could lead to the development of new and improved cancer drugs.
Australian Research Council, National Health and Medical Research Council of Australia

Contact: Dr. Daniel Ryan
Australian National University

Public Release: 9-Aug-2016
Environmental Science & Technology Letters
Unsafe levels of toxic chemicals found in drinking water for 6 million Americans
Levels of a widely used class of industrial chemicals linked with cancer and other health problems -- polyfluoroalkyl and perfluoroalkyl substances -- exceed federally recommended safety levels in public drinking water supplies for six million people in the US, according to a new study led by researchers from Harvard T.H. Chan School of Public Health and the Harvard John A. Paulson School of Engineering and Applied Sciences.
Smith Family Foundation, NIH/National Institute of Environmental Health Sciences, US Environmental Protection Agency, Danish Council for Strategic Research, Danish Environmental Protection Agency

Contact: Marge Dwyer
Harvard T.H. Chan School of Public Health

Public Release: 9-Aug-2016
Nature Communications
New study shows breast tumors evolve in response to hormone therapy
A new analysis of breast tumors, before and after hormone-reduction therapy, reveals the extreme genetic complexity of these tumors and the variety of responses that are possible to estrogen-deprivation treatments. The findings also suggest that analyzing a single sample of the breast tumor is insufficient for understanding how a patient should best be treated.
National Institutes of Health, Breast Cancer Research Foundation, Komen Promise Grant, Komen St. Louis Affiliate Clinical Trials Grant, Pfizer, Novartis, McNair Medical Foundation, Cancer Prevention Research Institute

Contact: Diane Duke Williams
Washington University School of Medicine

Public Release: 8-Aug-2016
Insurance status impacts survival in men with testicular cancer
Men with testicular cancer who were uninsured or on Medicaid had a higher risk of death from what is normally a curable disease than insured patients, a new study found.
National Institutes of Health

Contact: Anne Doerr
Dana-Farber Cancer Institute

Public Release: 8-Aug-2016
Cancer Cell
CNIO researchers have discovered a mechanism that allows cancer to survive without glucose
The finding provides important clues that might help understand the resistance to drugs that 'starve' tumors, and also how cancer cells manage to survive in the center of the tumor mass, where barely any blood vessels can reach. 'Tumor cells are very intelligent; when one door that seemed essential for their proliferation closes, they open new ones that allow them to adapt and survive,' says the intellectual author of the work, Nabil Djouder.
Spanish Ministry of Economy and Competitiveness, Worldwide Cancer Research

Contact: Cristina de Martos
Centro Nacional de Investigaciones Oncológicas (CNIO)

Public Release: 8-Aug-2016
Studies bolster evidence that insurance status affects cancer patients' health outcomes
Two new studies indicate that health insurance status may impact patients' health outcomes following a diagnosis of cancer. Cancer patients who were uninsured or had Medicaid coverage experienced a variety of disparities -- including being diagnosed at a later stage, receiving less than optimal treatment, and having shorter survival times -- when compared with patients with other forms of insurance. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society.

Contact: Dawn Peters

Public Release: 8-Aug-2016
Nature Chemical Biology
Compound shows promise as next-generation prostate cancer therapy
In the search for new ways to attack recurrent prostate cancer, researchers at Duke Health report that a novel compound appears to have a unique way of blocking testosterone from fueling the tumors in mice.
US Department of Defense, National Institutes of Health

Contact: Sarah Avery
Duke University Medical Center

Public Release: 8-Aug-2016
Cancer Cell
Low oxygen, high risk: How tumors adapt to become more aggressive
Wistar scientists have identified a novel mechanism that selectively operates in hypoxic tumors to enable tumor cells to thrive and continue to proliferate despite a low oxygen environment. Dario C. Altieri, M.D., Wistar's President and CEO and lead author of the study, and colleagues showed how the activation of this pathway leads to an unfavorable prognosis for patients with gliomas -- a type of brain tumor -- and how the pathway could be a valuable therapeutic target in cancer.
National Institutes of Health, Office of the Assistant Secretary of Defense for Health Affairs, Prostate Cancer Research Program, Prostate Cancer Foundation, Fondazione Cariplo, and others

Contact: Ben Leach
The Wistar Institute

Public Release: 8-Aug-2016
Nature Medicine
Study identifies novel treatment resistance mechanism in BRAF-mutant melanoma
A Massachusetts General Hospital research team has identified an additional mechanism for resistance to targeted treatment for BRAF-mutant melanoma. They report that inactivating mutations in two genes responsible for regulating key aspects of cell division can reactivate the signaling pathway driving tumor growth that had been blocked by BRAF inhibitor drugs.
Miriam and Sheldon Adelson Medical Research Foundation, V Foundation, Harry J. Lloyd Charitable Trust, Melanoma Research Alliance, National Institutes of Health

Contact: Julie Cunningham
Massachusetts General Hospital

Public Release: 8-Aug-2016
American Journal of Surgical Pathology
Needle biopsies for noninvasive breast cancer: Routine analysis wastes millions
For patients with the most common type of noninvasive breast cancer, routine testing for estrogen and progesterone receptors in tissue taken at the first 'needle' biopsy is both unnecessary and wasteful, according to results of a study led by Johns Hopkins pathologists.
Johns Hopkins University School of Medicine

Contact: Alsy Acevedo
Johns Hopkins Medicine

Public Release: 8-Aug-2016
New drug class gives hope for better treatments for incurable myeloma
Australian researchers have discovered that a new class of anti-cancer agents may be effective in treating multiple myeloma, an incurable bone marrow cancer.
National Health and Medical Research Council, Cancer Council Victoria, Leukemia and Lymphoma Society, Australian Cancer Research Foundation, China Scholarship Council, Victorian Government Operational Infrastructure Support Scheme

Contact: Vanessa Solomon
Walter and Eliza Hall Institute

Public Release: 8-Aug-2016
Health Affairs
Researchers turn to policy to tackle health disparities in an age of personalized medicine
Genetic research is a valuable tool in understanding diseases and their prevention, diagnosis, and treatment. However, significant obstacles limit the clinical use of this knowledge to all groups. Genetic applications in healthcare must advance in a way that reduces racial and ethnic disparities.
NIH/National Cancer Institute, NIH/National Heart, Lung, and Blood Institute, Komen Foundation and the Cancer Foundation for Minority and Underserved Populations, Renal Disease Epidemiology Training Program

Contact: Lisa LaPoint
Tufts University, Health Sciences Campus

Public Release: 8-Aug-2016
Thousands of new cancer cases in Ontario each year due to environmental exposures
Between 3,540 and 6,510 new cancer cases in Ontario each year result from environmental factors, says a new report from Cancer Care Ontario and Public Health Ontario (PHO).

Contact: Janet Wong
Public Health Ontario

Public Release: 8-Aug-2016
European Urology
Radical treatment and examination combined can halve mortality from prostate cancer
Men with very high-risk prostate cancer, who are treated at hospitals with a high proportion of administered radical local treatment (radiotherapy or prostatectomy), only have half of the mortality risk of men who are treated at hospitals with the lowest proportion. This is according to a new study conducted by researchers at Umeå University in Sweden and published in European Urology.

Contact: Daniel Harju
Umea University

Public Release: 5-Aug-2016
Science Immunology
Wistar scientists identify marker for myeloid-derived suppressor cells
Scientists at the Wistar Institute have identified a marker that distinguishes PMN-MDSCs from neutrophils in the blood of patients with a variety of cancers. Study results published in the journal Science Immunology also showed that higher numbers of cells positive for the marker were associated with larger tumor size.
National Institutes of Health, NIH/National Cancer Institute, American Cancer Society, Janssen Pharmaceutical

Contact: Darien Sutton
The Wistar Institute

Public Release: 5-Aug-2016
Scientific Reports
Research to improve treatment for millions of lung disease patients
New lung scanning technology developed at Monash University has the potential to transform treatment for millions of people with lung disease in Australia and around the world.

Contact: Monash media
Monash University

Public Release: 4-Aug-2016
The Lancet Oncology
The Lancet Oncology: Australian researchers uncover complex genetic secrets of cancer risk
In a landmark multi-country study, Australian researchers have transformed our understanding of the genes that affect our risk of cancer. The researchers uncovered numerous new genetic risk factors for the bone and soft-tissue cancer, sarcoma -- and, in a world first for any cancer, they showed that carrying several of these genetic mutations markedly increases an individual's cancer risk. The findings have immediate implications for how sarcomas and other cancers are treated.
Rainbows for Kate Foundation, Johanna Sewell Research Foundation, Australian National Health and Medical Research Council, Cancer Australia, Sarcoma UK, NIH/National Cancer Institute, Liddy Shriver Sarcoma Initiative

Contact: Anna Greenhalgh
Garvan Institute of Medical Research

Public Release: 4-Aug-2016
Every atom counts
Cancer cells are more dependent on a cellular garbage disposal unit -- the proteasome -- than healthy cells, and cancer therapies take advantage of this dependency. Scientists at EMBL and MPI determined the proteasome's 3D structure in unprecedented detail and have deciphered the exact mechanism by which inhibitor drugs block the proteasome. Their surprising results, published in Science, will pave the way to develop more effective treatments.
Deutsche Forschungsgemeinschaft, R & D Instruct grant

Contact: Sonia Furtado Neves
European Molecular Biology Laboratory

Public Release: 4-Aug-2016
The Lancet Oncology
Gene testing in rare tumor type could uncover 'cancer families'
Genetic testing of patients with a rare form of cancer that can affect children and young adults can pick out genetic errors hidden in their family tree which increase the risk of a wide variety of cancer types.
Sarcoma UK, Liddy Shriver Sarcoma Initiative

Contact: Claire Hastings
Institute of Cancer Research

Public Release: 4-Aug-2016
A surplus with consequences
Why do healthy cells become malignant and proliferate uncontrollably? Scientists of the University of Würzburg have investigated the role of a special protein in this process and settled and old controversy.

Contact: Dr. Elmar Wolf
University of Würzburg

Public Release: 4-Aug-2016
Science Translational Medicine
Researchers from CSI Singapore discover new way to inhibit development of lung cancer
A study led by Professor Daniel Tenen, Director of the Cancer Science Institute of Singapore at the National University of Singapore, found that inhibiting a protein called BMI1 could inhibit the development of lung cancer.

Contact: Goh Yu Chong
National University of Singapore

Public Release: 4-Aug-2016
Multitasking proteins: Unexpected properties of galectin-3
Biochemistry research on lectins and proteoglycans have been around as long as Frank Sinatra tunes. So finding out that these proteins interact is like discovering Sinatra and Elvis started a band way back when. In a study published in Biochemistry this week, researchers from Michigan Technological University explain how this finding could impact cancer and immune system research.
Research Excellence Fund through Michigan Tech

Contact: Tarun Dam
Michigan Technological University

Public Release: 4-Aug-2016
American Journal of Epidemiology
Study links increased ovarian cancer risk with lower socioeconomic status in African-American women
Higher socioeconomic status was associated with lower ovarian cancer risk in African-American women, according to study results reported by investigators at the Medical University of South Carolina and elsewhere in the American Journal of Epidemiology. Women with a college degree had a 29 percent lower risk of ovarian cancer; risk was also lower in women with a household income of $75,000 or more compared to those with household incomes of $10,000 or less.
National Institutes of Health

Contact: Allison Leggett
Medical University of South Carolina

Public Release: 4-Aug-2016
Journal of Leukocyte Biology
Blocking the migration of cancer cells to destroy them
Swiss researchers developed an experimental immunotherapeutic strategy which paves the way for new treatments against lymphoma, a cancer that affects lymphocytes, a type of white blood cell. Their innovative approach consists in using an antibody able to neutralize a specific protein to block the migration of lymphoma cells, thus preventing the disease from developing.

Contact: Thomas Matthes
Université de Genève

Showing releases 126-150 out of 1374.

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