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Public Release: 13-Aug-2015
How the malaria parasite increases the risk of blood cancer
A link between malaria and Burkitt's lymphoma was first described more than 50 years ago, but how a parasitic infection could turn immune cells cancerous has remained a mystery. Now, in the Aug. 13 issue of Cell, researchers demonstrate in mice that B cell DNA becomes vulnerable to cancer-causing mutations during prolonged combat against the malaria-causing Plasmodium falciparum.
National Institutes of Health, Worldwide Cancer Research, Fondazione Ettore e Valeria Rossi

Contact: Joseph Caputo
Cell Press

Public Release: 13-Aug-2015
International Journal of Obesity
Heavy smokers and smokers who are obese gain more weight after quitting
For smokers, the number of cigarettes smoked per day and current body mass index are predictive of changes in weight after quitting smoking, according to researchers at Penn State College of Medicine.
Penn State Hershey Cancer Institute

Contact: Matt Solovey
Penn State

Public Release: 13-Aug-2015
JAMA Oncology
Multigene panel testing for hereditary breast/ovarian cancer risk assessment
Multigene testing of women negative for BRCA1 and BRCA2 found some of them harbored other harmful genetic mutations, most commonly moderate-risk breast and ovarian cancer genes and Lynch syndrome genes, which increase ovarian cancer risk, according to an article published online by JAMA Oncology.

Contact: Katie Marquedant
The JAMA Network Journals

Public Release: 13-Aug-2015
Cell Reports
Corrected protein structure reveals drug targets for cancer, neurodegenerative diseases
Protein Kinase C is a family of enzymes that controls the activity of other proteins in a cell by attaching chemical tags. That simple act helps determine cell survival or death. When it goes awry, a number of diseases may result. In a study, researchers at University of California, San Diego School of Medicine reveal a more accurate structure of PKC, providing new targets for fine-tuning the enzyme's activity as needed to improve human health.
National Institutes of Health, National Science Foundation

Contact: Heather Buschman
University of California - San Diego

Public Release: 13-Aug-2015
JAMA Oncology
Screening for breast/ovarian cancer risk genes other than BRCA1/2 is clinically valuable
A study by researchers at three academic medical centers has shown that screening women with a suspected risk of hereditary breast or ovarian cancer for risk-associated genes other than BRCA1 and 2 provides information that can change clinical recommendations for patients and their family members.
MGH Friends Fighting Breast Cancer, Tracey Davis Memorial Fund, Breast Cancer Research Foundation

Contact: Katie Marquedant
Massachusetts General Hospital

Public Release: 13-Aug-2015
New research helps explain why a deadly blood cancer often affects children with malaria
Children in equatorial Africa who suffer from malaria are at high risk of developing Burkitt's lymphoma, a highly aggressive blood cancer. A new study sheds light on the long-standing mystery of how the two diseases are connected.

Contact: Wynne Parry
Rockefeller University

Public Release: 13-Aug-2015
Journal of Investigative Dermatology
Transplant recipients more likely to develop aggressive melanoma
Organ transplant recipients are twice as likely to develop melanoma as people who do not undergo a transplant, and three times more likely to die of the dangerous skin cancer, suggests new research led by a Johns Hopkins Bloomberg School of Public Health student.
NIH/National Cancer Institute

Contact: Stephanie Desmon
Johns Hopkins University Bloomberg School of Public Health

Public Release: 12-Aug-2015
Nature Communications
Tell-tale biomarker detects early breast cancer in NIH-funded study
Researchers have shown that MRI can detect the earliest signs of breast cancer recurrence and fast-growing tumors. Their approach detects micromestastases, breakaway tumor cells with the potential to develop into dangerous secondary breast cancer tumors elsewhere in the body. The approach may offer an improved way to detect early recurrence of breast cancer. The work was completed at Case Western Reserve University and was funded by the National Institute of Biomedical Imaging and Bioengineering, part of NIH.
NIH/National Institute of Biomedical Imaging and Bioengineering

Contact: Raymond A MacDougall
NIH/National Institute of Biomedical Imaging & Bioengineering

Public Release: 12-Aug-2015
Cancer Discovery
Blood vessel 'doorway' lets breast cancer cells spread through blood stream
Using real-time, high-resolution imaging, scientists have identified how a 'doorway' in the blood vessel wall allows cancer cells to spread from breast tumors to other parts of the body. The findings support emerging tests that better predict if breast cancer will spread, which could spare women from unnecessary treatments and lead to new anti-cancer therapies. The research from Albert Einstein Cancer Center and Montefiore Einstein Center for Cancer Care published today in Cancer Discovery.
Department of Defense Breast Cancer Research Program, National Institutes of Health, Einstein's Integrated Imaging Program

Contact: Deirdre Branley
Albert Einstein College of Medicine

Public Release: 12-Aug-2015
Nature Communications
New contrast agent spotlights tiny tumors and micrometastases
Researchers at Case Western Reserve University have developed a magnetic resonance imaging contrast agent that detects much smaller aggressive breast cancer tumors and micrometastases than current agents can identify. The key to earlier detection is a small peptide gadolinium-based agent that binds to molecular markers, called fibrin-fibronectin complexes. The complexes are expressed in high-risk primary tumors and metastases.
National Institutes of Health

Contact: Kevin Mayhood
Case Western Reserve University

Public Release: 12-Aug-2015
Journal of Hepatology
Intrahepatic cholestasis of pregnancy linked with liver cancer
In a new study of more than 125,000 pregnant women in Sweden, researchers at the Sahlgrenska Academy found that the risk of hepatobiliary cancer and immune-mediated and cardiovascular diseases later in life is higher in women with intrahepatic cholestasis of pregnancy than in women without this condition. Their results are published in the Journal of Hepatology.

Contact: Hanns-Ulrich Marschall
University of Gothenburg

Public Release: 12-Aug-2015
Target healthy cells to stop brain cancer 'hijack': UBC study
New UBC research into brain cancer suggests treatments should target the cells around a tumor to stop it from spreading.

Contact: Heather Amos
University of British Columbia

Public Release: 12-Aug-2015
Journal of Biological Chemistry
Can stem cells cause and cure cancer?
Simply put, cancer is caused by mutations to genes within a cell that lead to abnormal cell growth. Finding out what causes that genetic mutation has been the holy grail of medical science for decades. Researchers at the Texas A&M Health Science Center Institute of Biosciences and Technology believe they may have found one of the reasons why these genes mutate and it all has to do with how stem cells talk to each other.
National Institutes of Health, Cancer Prevention and Research Institution of Texas Grant, Natural Science Foundation of Zhejiang Province of China, National Natural Science Foundation of China

Contact: Holly Shive
Texas A&M University

Public Release: 12-Aug-2015
Cancer Research
Combining chemotherapy with an immune-blocking drug could stop cancer growing back
Giving patients a drug that blocks part of the immune system from going into overdrive might help prevent cancer coming back in some people, according to research published in Cancer Research.
Cancer Research UK, Medical Research Council, Wellcome Trust

Contact: Liz Smith
Cancer Research UK

Public Release: 12-Aug-2015
Journal of American Geriatrics Society
UTHealth research: Older breast cancer patients less likely to benefit from chemo
Chemotherapy prolongs life for older adults with most types of cancer, but for women over the age of 80 with breast cancer, the chances of survival due to chemotherapy are significantly lower, according to a study led by researchers from The University of Texas Health Science Center at Houston (UTHealth).
Agency for Healthcare Research and Quality, Cancer Prevention Research Institute of Texas

Contact: Hannah Rhodes
University of Texas Health Science Center at Houston

Public Release: 12-Aug-2015
Cancer Discovery
Pancreas cancer spread from multiple types of wayward cells
Tumor cells associated with pancreatic cancer often behave like communities by working with each other to increase tumor spread and growth to different organs. Groups of these cancer cells are better than single cancer cells in driving tumor spread. These results may prove useful in designing better targeted therapies to stop tumor progression and provide an improved non-invasive method for detecting early disease states in this highly lethal cancer.
NIH/National Cancer Institute, Penn Center for Molecular Studies in Digestive and Liver Diseases, Paul Calabresi Career Development Award, Abramson Family Cancer Research Institute

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 11-Aug-2015
Journal of Adolescent and Young Adult Oncology
The ethics and risks of expecting teen siblings to be transplant donors
A sibling may often be the best match for a patient who needs a stem cell transplant, but especially for adolescent donors, who are at a vulnerable age, factors such as the responsibility to donate versus a perception of free choice and the potential for anxiety and guilt in the face of complications or poor outcomes demand careful consideration. The benefits, burdens, and risks of adolescent sibling stem cell donation are discussed in an article in Journal of Adolescent and Young Adult Oncology.

Contact: Kathryn Ryan
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 11-Aug-2015
Journal of the American Academy of Dermatology
New combination treatment effective against melanoma skin
In findings never before seen in melanoma, a novel combination therapy was found to be highly effective at treating patients with skin metastases, new research from UC Davis has shown.
Burroughs Wellcome Fund, Howard Hughes Medical Institute and National Institutes of Health

Contact: Charles Casey
University of California - Davis Health System

Public Release: 11-Aug-2015
Journal of Oncology Practice
Radiation costs vary among Medicare patients with cancer
Cost of radiation therapy among Medicare patients varied most widely because of factors unrelated to a patient or that person's cancer, report University of California, San Diego School of Medicine researchers in the Journal of Oncology Practice.
National Institutes of Health

Contact: Yadira Galindo
University of California - San Diego

Public Release: 11-Aug-2015
Penn study details 'rotten egg' gas' role in autoimmune disease
A new study led by Songtao Shi of the University of Pennsylvania has demonstrated how regulatory T cells can themselves be regulated, by an unexpected source: hydrogen sulfide, a gas produced by the body's muscle cells and one often associated with the smell of rotten eggs.
NIH/National Institute of Dental and Craniofacial Research, Ministry of Science and Technology, China, Department of Health and Human Services

Contact: Katherine Unger Baillie
University of Pennsylvania

Public Release: 10-Aug-2015
Chemical Reviews
Scientists present review of liposomes: A basis for drugs of the future
An international group of scientists, including Vladimir Chupin, head of the Biophysics Section at MIPT, and Vladimir Torchilin (Northeastern University, the USA), one of the world's leading experts in pharmacology, recently presented a review of liposomes, microscopic capsules widely used all over the world in the development of new drugs. Their review, published in the scientific journal Chemical Review, discusses the major achievements in the field and points to the most promising areas for its further development.

Contact: Stanislav Goryachev
Moscow Institute of Physics and Technology

Public Release: 10-Aug-2015
Researchers develop advanced cell screening technology for cancer immunotherapy
Researchers have created a new method for screening cells used in immunotherapy cancer treatments, allowing high-performing immune system cells to be studied in isolation and potentially expanding the number of patients for whom the breakthrough treatment proves successful.

Contact: Jeannie Kever
University of Houston

Public Release: 10-Aug-2015
Science Signaling
Researchers identify nerve-guiding protein that aids pancreatic cancer spread
Scientists at the Johns Hopkins Kimmel Cancer Center have identified a molecular partnership in pancreatic cancer cells that might help to explain how the disease spreads -- metastasizes -- in some cases. Their findings reveal urgently needed new targets to treat pancreatic cancer, which strikes nearly 50,000 people in the US each year and has only a 5 percent survival rate five years after diagnosis.
NIH/National Cancer Institute, Viragh Foundation, Johns Hopkins/Skip Viragh Pancreatic Cancer Center, Lefkofsky Family Foundation, Lustgarten Foundation

Contact: Amy Mone
Johns Hopkins Medicine

Public Release: 10-Aug-2015
Nature Neuroscience
Common class of 'channel blocking' drugs may find a role in cancer therapy
Research findings in fruit flies and mice by UC San Francisco scientists that led to unconventional treatment of a case of metastatic brain cancer.

Contact: Peter Farley
University of California - San Francisco

Public Release: 10-Aug-2015
Proceedings of the National Academy of Sciences
Scripps Florida scientists determine how antibiotic gains cancer-killing sulfur atoms
In a discovery with implications for future drug design, scientists from the Florida campus of The Scripps Research Institute have shown an unprecedented mechanism for how a natural antibiotic with antitumor properties incorporates sulfur into its molecular structure, an essential ingredient of its antitumor activity.
National Institutes of Health

Contact: Eric Sauter
Scripps Research Institute

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