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Public Release: 30-Sep-2014
Oncotarget
First mapping that reveals the molecular pathway for MDSC cancer progression
InSilico Medicine and partners establish a map for cancer progression induced by MDSCs, and a means to extinguish them.
Federal Clinical Research Center of Pediatric Hematology, Oncology and Immunology

Contact: Michael Petr
michael.petr@insilicomedicine.com
InSilico Medicine, Inc.

Public Release: 30-Sep-2014
Proceedings of the National Academy of Sciences
New discovery approach accelerates identification of potential cancer treatments
Researchers at the University of Michigan have described a new approach to discovering potential cancer treatments that requires a fraction of the time needed for more traditional methods.
Life Sciences Institute's Innovation Partnership

Contact: Laura Williams
laurajw@umich.edu
734-615-4862
University of Michigan

Public Release: 30-Sep-2014
Journal of General Internal Medicine
Endoscopists recommend frequent colonoscopies, leading to its overuse
A retrospective study led by researchers at Brigham and Women's Hospital, has found an overuse of colonoscopies for colorectal cancer screening and surveillance. The study demonstrated that endoscopists commonly recommended shorter follow-up intervals than established guidelines support, and these recommendations were strongly correlated with subsequent colonoscopy overuse.
NIH/National Cancer Institute

Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-525-6383
Brigham and Women's Hospital

Public Release: 30-Sep-2014
JAMA
Medical professional liability claims and esophageal cancer screening
An analysis of liability claims related to esophageal cancer screening finds that the risks of claims arising from acts of commission -- complications from screening procedure -- as well as acts of omission -- failure to screen -- are similarly low, according to a study in the Oct. 1 issue of JAMA.

Contact: Shantell Kirkendoll
smkirk@umich.edu
734-764-2220
The JAMA Network Journals

Public Release: 30-Sep-2014
Health Technology Assessment
Genetic test would help 'cut bowel cancer spread'
Screening families of patients with bowel cancer for a genetic condition would cut their risk of developing bowel, womb, and ovarian cancers, new research has found.
National Institute for Health Research

Contact: Chris Jones
jonesc83@cardiff.ac.uk
Cardiff University

Public Release: 30-Sep-2014
British Journal of Cancer
Targeted treatment could halt womb cancer growth
A drug which targets a key gene fault could halt an aggressive womb cancer and shrink tumours, according to research published in the British Journal of Cancer.

Contact: Emily Head
emily.head@cancer.org.uk
44-203-469-6189
Cancer Research UK

Public Release: 30-Sep-2014
Journal of General Internal Medicine
Americans undergo colonoscopies too often, study finds
Colonoscopies are a very valuable procedure by which to screen for the presence of colorectal cancer. However, it seems that healthy Americans who do undergo this sometimes uncomfortable examination often have repeat screenings long before they actually should. Gina Kruse of Massachusetts General Hospital in the US and colleagues advise that endoscopists stick to the national guidelines more closely. Their findings appear in the Journal of General Internal Medicine, published by Springer.
National Cancer Institute, Health Resources and Services Administration, Ryoichi Sasakawa Fellowship Fund

Contact: Joan Robinson
joan.robinson@springer.com
49-622-148-78130
Springer

Public Release: 30-Sep-2014
Health Technology Assessment
Genetic test for cancer patients could be cost-effective and prevent further cases
Screening for a genetic condition in younger people who are diagnosed with bowel cancer would be cost-effective for the British National Health Service and prevent new cases in them and their relatives, new research has concluded.
National Institute for Health UK

Contact: Louise Vennells
l.vennells@exeter.ac.uk
0044-139-272-2062
University of Exeter

Public Release: 30-Sep-2014
FASEB Journal
New blood test determines whether you have or are likely to get cancer
A new research report published in the October 2014 issue of the FASEB Journal may make early detection and the risk assessment of cancer as easy as a simple blood test.

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology

Public Release: 30-Sep-2014
Angewandte Chemie International Edition
Cancer therapy: Driving cancer cells to suicide
Researchers of Ludwig-Maximilians-Universitaet in Munich report that a new class of chemical compounds makes cancer cells more sensitive to chemotherapeutic drugs. They have also pinpointed the relevant target enzyme, thus identifying a new target for anti-tumor agents.

Contact: Luise Dirscherl
presse@lmu.de
49-982-180-3423
Ludwig-Maximilians-Universität München

Public Release: 30-Sep-2014
New England Journal of Medicine
NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer
In this multi-center study of 50 patients with advanced non-small cell lung cancer testing positive for ROS1 gene rearrangement, the response rate was 72 percent, with 3 complete responses and 33 partial responses. Median progression-free survival was 19.2 months.
NIH/National Cancer Institute

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

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