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Public Release: 19-Jan-2016
Journal of Surgical Research
Study shows surge in use of CTs in patients with minor injuries
Twice as many patients with non-serious injuries, such as fractures or neck strain, are undergoing CT scans in emergency departments at California hospitals, according to a UCSF-led study, which tracked the use of the imaging from 2005 to 2013.

Contact: Suzanne Leigh
suzanne.leigh@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 19-Jan-2016
JAMA
Cost of end-of-life care in the US is comparable to Europe and Canada
Despite widespread perception, the United States does not provide the worst end-of-life care in the world. In the first international comparison of end-of-life care practices, researchers from Penn and colleagues from seven countries found that the United States actually has the lowest proportion of deaths in the hospital and the lowest number of days in the hospital in the last six months of life among the those countries, according to a new study published today in JAMA.
NIH/National Institute on Aging, NIH/National Cancer Institute, Commonwealth Fund

Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-349-5964
University of Pennsylvania School of Medicine

Public Release: 18-Jan-2016
JAMA
Georgetown professors: Congress made 'scientific judgment for which it is distinctly unqualified'
Two Georgetown University professors say a section of the recently passed Congressional spending bill effectively undermines science and the health of women. Their JAMA Viewpoint, 'A Public Health Framework for Screening Mammography: Evidence-Based Versus Politically Mandated Care,' will be published Monday.

Contact: Karen Teber
km463@georgetown.edu
O'Neill Institute for National and Global Health Law

Public Release: 18-Jan-2016
Nature Medicine
New findings may enhance PARP inhibitors therapy in breast cancer
Findings from a new study reveal that PARP inhibitors, an emerging class of drugs being studied in cancer clinical trials, may be enhanced by combining them with inhibitors targeting an oncogene known as c-MET which is overexpressed in many cancers.

Contact: Ron Gilmore
rlgilmore1@mdanderson.org
713-745-1898
University of Texas M. D. Anderson Cancer Center

Public Release: 18-Jan-2016
Nature Genetics
Laws of nature predict cancer evolution
The spread of mutations through a cancer follows natural laws -- and is therefore theoretically predictable, just as we can predict the movement of celestial bodies or the weather, a study shows. This intriguing research raises the possibility that doctors could take clinical decisions on how an individual patient's cancer will change, and what treatments should be used, by applying mathematical formulas to tumor biopsies.
Wellcome Trust, Cancer Research UK, Medical Research Council

Contact: Henry French
henry.french@icr.ac.uk
020-715-35582
Institute of Cancer Research

Public Release: 18-Jan-2016
Genes & Development
Protein 'handbrake' halts leukemia in its tracks
Melbourne researchers have showed that they can stop leukemia in its tracks by targeting a protein that puts the handbrake on cancer cell growth. The researchers discovered that targeting a protein called Hhex could cure acute myeloid leukemia (AML) in preclinical disease models, and could be a key target for new therapies for human leukemia.
National Health and Medical Research Council, Cancer Council of Victoria, Leukaemia Foundation of Australia, Australian Research Council, Australian Cancer Research Fund, Victorian State Government Operational Infrastructure Support

Contact: Liz Williams
williams@wehi.edu.au
61-428-034-089
Walter and Eliza Hall Institute

Public Release: 18-Jan-2016
Journal of Adolescent and Young Adult Oncology
New research from MSK highlights fertility concerns of young adult and adolescent cancer survivors
Nearly half of young adult survivors of adolescent cancers -- more young men than women -- report uncertainty about their fertility, according to the results of a new study. While females were more likely to describe feeling distressed and overwhelmed and tended to worry more about pregnancy-related health risks and cancer recurrence, both sexes had concerns about genetic risk factors and how infertility might impact their future lives, as described in the study published in Journal of Adolescent and Young Adult Oncology.

Contact: Kathryn Ryan
kryan@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 18-Jan-2016
Cancer Biology & Therapy
Finding the needle in a microbial haystack
After developing a novel investigational technology called PathoChip that can rapidly identify elusive microorganisms, a team of Penn Medicine researchers recently succeeded for the first time in identifying a pathogen in a patient sample, demonstrating the proof of principle that this technology can be used to identify pathogens in human disease.
Avon Foundation Grant, Abramson Cancer Center Director's Fund

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 18-Jan-2016
Journal of the National Cancer Institute
Scientists find new gene fault behind ovarian cancer
Women who carry an inherited fault in the gene BRIP1 are over three times more likely to develop ovarian cancer than those without the fault, according to a study published in the Journal of the National Cancer Institute.

Contact: Emily Head
emily.head@cancer.org.uk
44-203-469-6189
Cancer Research UK

Public Release: 18-Jan-2016
Nature Genetics
DNA methylation pattern in leukemia only appears to be cancer-typical
The pattern of epigenetic labels in the DNA of cancer cells differs from that of healthy cells. This has been considered a characteristic of cancer. Scientists from the German Cancer Research Center have now discovered in blood cancer that the labeling pattern of the cancer cells more likely reflects the maturation stage of cancer precursor cells at the moment of carcinogenesis, rather than representing a cancer-typical variation.

Contact: Dr. Sibylle Kohlstädt
s.kohlstaedt@dkfz.de
German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)

Public Release: 15-Jan-2016
European Molecular Biology Organization Journal
Brothers-in-arms: How P53 and telomeres work together to stave off cancer
New research from scientists at The Wistar Institute shows that p53 is able to suppress accumulated DNA damage at telomeres. This is the first time this particular function of p53 has ever been described and shows yet another benefit of this vital gene.
National Institutes of Health, Philadelphia Health Care Trust, Pennsylvania Department of Health

Contact: Ben Leach
bleach@wistar.org
215-495-6800
The Wistar Institute

Public Release: 15-Jan-2016
Cancer Research
Link between obesity and increased risk of colorectal cancer revealed
Thomas Jefferson University scientists say the culprit is excess calories, but risk can be reversed through lifestyle modification or, potentially, use of an approved drug.

Contact: Colleen Cordaro
colleen.cordaro@jefferson.edu
215-955-2238
Thomas Jefferson University

Public Release: 15-Jan-2016
CA: A Cancer Journal for Clinicians
Report: Wide variation in cancer rates in Asian American/Native Hawaiian/Pacific Islanders
A new report describes cancer among Asian Americans, Native Hawaiians, and Pacific Islanders (AANHPIs), and reports striking variation in the cancer burden within this population, reflecting vast differences in exposure to cancer risk factors.
American Cancer Society, NIH/National Cancer Institute

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society

Public Release: 14-Jan-2016
Cancer Epidemiology, Biomarkers & Prevention
HPV vaccine uptake is highest among girls in high poverty and majority Hispanic communities
Adolescent girls living in high-poverty communities and majority Hispanic communities were more likely to have received at least one dose of a human papillomavirus (HPV) vaccine than those living in low-poverty communities and in communities of other racial and ethnic compositions.
Huntsman Cancer Institute Foundation, Primary Children's Hospital Foundation, Beaumont Foundation, National Institutes of Health

Contact: Lauren Riley
lauren.riley@aacr.org
215-446-7155
American Association for Cancer Research

Public Release: 14-Jan-2016
Science
TSRI chemists devise powerful new method for modifying drug molecules
Chemists at The Scripps Research Institute have developed a versatile new technique for making modifications -- especially one type of extremely difficult, but much-sought-after modification -- to complex drug molecules.
Pfizer, National Institutes of Health

Contact: Madeline McCurry-Schmidt
madms@scripps.edu
858-784-9254
Scripps Research Institute

Public Release: 14-Jan-2016
Cell
New blood test may expand scope of liquid biopsies
A new approach to liquid biopsies may overcome limitations of current blood tests to diagnose and monitor cancers, birth defects, organ transplants and autoimmune disorders. The method relies on analyzing fragmentation patterns in the cell-free DNA in an individual, and comparing them to what might be expected for cell death associated with various medical or physiological conditions. For some types of cancers, researchers could identify the anatomical source of the tumor, which could aid in diagnosing metastatic cancers whose origin is unknown.
National Institutes of Health Director's Pioneer Award

Contact: Michael McCarthy
leilag@u.washington.edu
206-685-0381
University of Washington Health Sciences/UW Medicine

Public Release: 14-Jan-2016
JAMA Oncology
Palliative care initiated in the ED associated with improved quality of life
A palliative care consultation initiated in the emergency department (ED) for patients with advanced cancer was associated with improved quality of life and did not seem to shorten survival, according to an article published online by JAMA Oncology.

Contact: Rob Magyar
Robert.magyar@nyumc.org
212-404-3591
The JAMA Network Journals

Public Release: 14-Jan-2016
Cell
Breast cancer study suggests new potential drug targets and combinations
The largest analysis of breast cancer cell function to date suggests dozens of new uses for existing drugs, new targets for drug discovery, and new drug combinations.
National Institutes of Health, Komen, MD Anderson Cancer Center, Canadian Foundation for Innovation, The Princess Margaret Cancer Foundation, Canadian Breast Cancer Foundation

Contact: Greg Williams
gregory.williams@nyumc.org
212-404-3533
New York University

Public Release: 14-Jan-2016
Nanomedicine: Nanotechnology, Biology, and Medicine
UNC-Chapel Hill researchers kill drug-resistant lung cancer with 50 times less chemo
The cancer drug paclitaxel just got more effective. For the first time, researchers from the University of North Carolina at Chapel Hill have packaged it in containers derived from a patient's own immune system, protecting the drug from being destroyed by the body's own defenses and bringing the entire payload to the tumor.
National Institutes of Health, Carolina Partnership, University Cancer Research Fund, Russian Federation Ministry of Education and Science

Contact: Thania Benios
thania_benios@unc.edu
919-962-8596
University of North Carolina at Chapel Hill

Public Release: 14-Jan-2016
Nature Nanotechnology
New particle can track chemo
Tracking the path of chemotherapy drugs in real time and at a cellular level could revolutionize cancer care and help doctors sort out why two patients might respond differently to the same treatment. Researchers at The Ohio State University have found a way to light up a common cancer drug so they can see where the chemo goes and how long it takes to get there.
National Science Foundation

Contact: Mingjun Zhang
Zhang.4882@osu.edu
614-292-3181
Ohio State University

Public Release: 14-Jan-2016
PLOS ONE
Study finds how diabetes drug metformin inhibits progression of pancreatic cancer
Massachusetts General Hospital investigators may have uncovered a novel mechanism behind the ability of the diabetes drug metformin to inhibit the progression of pancreatic cancer. In their report the research team describes finding that metformin decreases the inflammation and fibrosis characteristic of the most common form of pancreatic cancer.
National Institutes of Health, Lustgarten Foundation, Foundation for Science and Technology of Portugal

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital

Public Release: 13-Jan-2016
Molecular Cancer Research
TGen study targets SGEF protein in treating glioblastoma brain tumors
The Translational Genomics Research Institute (TGen) has identified a protein called SGEF that promotes the survival of glioblastoma tumor cells and helps the cancer invade brain tissue. TGen researchers identified SGEF as a target for new brain cancer therapies in a study published today by Molecular Cancer Research, a journal of the American Association for Cancer Research, the world's largest professional organization dedicated to advancing cancer research.
National Institutes of Health, ARCS Foundation Eller Scholarship and Science Foundation Arizona Fellowship, The Ben & Catherine Ivy Foundation

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute

Public Release: 13-Jan-2016
PLOS ONE
Liver recovery difficult even with improved diet -- but faster if sugar intake is low
Liver damage caused by the typical 'Western diet' -- one high in fat, sugar and cholesterol that's common in developed countries such as the United States -- may be difficult to reverse even if diet is generally improved, a new study shows. Meanwhile, liver problems such as nonalcoholic fatty liver disease are surging in the US, affecting 10-35 percent of adults and an increasing number of children.
National Institutes of Health, US Department of Agriculture

Contact: Donald Jump
Donald.jump@oregonstate.edu
541-737-4007
Oregon State University

Public Release: 12-Jan-2016
Journal of Controlled Release
Cancer-killing proteins destroy tumor cells in bloodstream
Cornell researchers have discovered potent cancer-killing proteins that can travel by white blood cells to kill tumors in the bloodstream of mice with metastatic prostate cancer.
National Institutes of Health

Contact: Melissa Osgood
mmo59@cornell.edu
607-255-2059
Cornell University

Public Release: 12-Jan-2016
Cancer Medicine
Colorectal cancer more likely to affect minorities at younger age
Colorectal cancer is the third most common form of cancer and the second most common cause of cancer deaths in the United States. The chance of developing colorectal cancer increases with age. Now, a study by University of Missouri School of Medicine researchers shows that minority and ethnic groups are being diagnosed with colorectal cancer at younger ages and more advanced stages than non-Hispanic whites.

Contact: Jeff Hoelscher
hoelscherj@missouri.edu
573-884-1608
University of Missouri-Columbia

Showing releases 1251-1275 out of 1353.

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