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Showing releases 1251-1275 out of 1312.

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Public Release: 16-Mar-2015
Journal of the National Cancer Institute
Exercise affects tumor growth and drug response in a mouse model of breast cancer
Abnormal growth of blood vessels in solid tumors creates areas of hypoxia, which, in turn makes the tumors more aggressive and resistant to therapy. Exercise has been shown to improve blood vessel growth and perfusion of normal tissues and may have the same effect in solid tumors, according to a study published March 16 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
Oxford University Press USA

Public Release: 13-Mar-2015
Molecular Cancer Research
Nodal alone does not produce anti-cancer effects
In a new study, standard treatments for metastatic melanoma are not effective against a growth factor protein called Nodal.
National Institutes of Health, NIH/National Cancer Institute, Eisenberg Research Scholar, Robert Kris Family

Contact: Peggy Murphy
Ann & Robert H. Lurie Children's Hospital of Chicago

Public Release: 13-Mar-2015
Food and Drug Law Journal
Georgetown legal scholar: E-cigarettes can be regulated now without more research
A legal scholar and tobacco control expert says he has developed a research-based roadmap that allows for the immediate regulation of e-cigarettes.

Contact: Karen Teber
O'Neill Institute for National and Global Health Law

Public Release: 13-Mar-2015
Clinical Cancer Research
Genetically engineered immunotoxin shows early promise in patients with B-cell malignancies
DT2219, a new bispecific ligand-directed diphtheria toxin, was found to be safe and clinically effective in a small group of patients with relapsed/refractory B-cell malignancies, according to phase I clinical trial data.
National Institutes of Health, Randy Shaver Foundation, Lions Children's Cancer Fund, William Lawrence and Blanche Hughes Foundation

Contact: Lauren Riley
American Association for Cancer Research

Public Release: 13-Mar-2015
Nature Communications
Organisms can keep gene expression in check: York U biologist
The current study, jointly conducted by York University and Columbia University researchers, suggests that Small Ubiquitin-like Modifier modifies proteins bound to active genes, in order to prevent unfettered gene over-expression that can be harmful to the organism.

Contact: Gloria Suhasini
416-736-2100 x22094
York University

Public Release: 13-Mar-2015
20th Annual Meeting of the National Comprehensive Cancer Network
NCCN publishes new guidelines for smoking cessation
To meet the needs of patients who are smokers at the time of a cancer diagnosis, the National Comprehensive Cancer Network (NCCN) has published the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Smoking Cessation. The NCCN Guidelines® for Smoking Cessation were presented on March 13, 2015, at the NCCN 20th Annual Conference: Advancing the Standard of Cancer Care. The guideline committee was chaired by Peter Shields, M.C., deputy director of The Ohio State University Comprehensive Cancer Center.

Contact: Amanda J Harper
Ohio State University Wexner Medical Center

Public Release: 12-Mar-2015
JAMA Oncology
Study examines association of inappropriate prostate, breast cancer imaging
An association of high rates of inappropriate imaging for prostate cancer and breast cancer identified in a study of Medicare beneficiaries suggests that, at the regional level, regional culture and infrastructure could contribute to inappropriate imaging, something policymakers should want to consider as they seek to improve the quality of care and reduce health care spending, according to a study published online by JAMA Oncology.

Contact: Jim Mandler
The JAMA Network Journals

Public Release: 12-Mar-2015
JAMA Oncology
Germline TP53 mutations in patients with early-onset colorectal cancer
In a group of patients diagnosed with colorectal cancer at 40 or younger, 1.3 percent of the patients carried germline TP53 gene mutations, although none of the patients met the clinical criteria for an inherited cancer syndrome associated with higher lifetime risks of multiple cancers, according to a study published online by JAMA Oncology.

Contact: Anne Doerr
The JAMA Network Journals

Public Release: 12-Mar-2015
JAMA Oncology
Geography matters: Imaging overuse seen in certain US regions
Researchers from NYU Langone Medical Center conclude that patients with low-risk prostate or breast cancer were more likely to receive inappropriate imaging during treatment, based on the region of the country in which they received medical care.
Robert Wood Johnson Foundation, Louis Feil Charitable Lead Trust, US Department of Veterans Affairs

Contact: Jim Mandler
NYU Langone Medical Center / New York University School of Medicine

Public Release: 12-Mar-2015
Cell Reports
Stem cells lurking in tumors can resist treatment
Scientists are eager to make use of stem cells' extraordinary power to transform into nearly any kind of cell, but that ability also is cause for concern in cancer treatment. For the first-time, scientists at Washington University School of Medicine in St. Louis have isolated treatment-resistant cancer stem cells from low-grade tumors.

Contact: Michael C. Purdy
Washington University School of Medicine

Public Release: 12-Mar-2015
Reaching '80 percent by 2018' would prevent more than 20,000 colorectal cancer deaths per year
Increasing colorectal cancer screening rates to 80 percent by 2018 would prevent an additional 21,000 colorectal cancer deaths per year by 2030, according to a new study.
NIH/National Cancer Institute, American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 12-Mar-2015
Magnetic brain stimulation
Magnetic nanoparticles could allow brain stimulation without wires.

Contact: Andrew Carleen
Massachusetts Institute of Technology

Public Release: 12-Mar-2015
Cell Reports
New genome-editing technology to help treat blood cancers
Melbourne researchers have developed a new genome editing technology that can target and kill blood cancer cells with high accuracy. Using the technology, researchers from the Walter and Eliza Hall Institute were able to kill human lymphoma cells by locating and deleting an essential gene for cancer cell survival.
National Health and Medical Research Council, Leukaemia Foundation, Kay Kendall Leukemia Fund and Victorian Government.

Contact: Liz Williams
Walter and Eliza Hall Institute

Public Release: 12-Mar-2015
Case Western Reserve scientists find hidden meaning and 'speed limits' within genetic code
Case Western Reserve scientists have discovered that speed matters when it comes to how messenger RNA deciphers critical information within the genetic code -- the complex chain of instructions critical to sustaining life. The investigators' findings, which appear in the March 12 journal Cell, give scientists critical new information in determining how best to engage cells to treat illness -- and, ultimately, keep them from emerging in the first place.
National Institutes of Health

Contact: Jeannette Spalding
Case Western Reserve University

Public Release: 12-Mar-2015
Proceedings of the National Academy of Sciences
Building a genomic GPS
A new 'app' for finding and mapping chromosomal loci using multicolored versions of CRISPR/Cas9, one of the hottest tools in biomedical research today, has been developed by scientists at the University of Massachusetts Medical School.
National Science Foundation

Contact: Jim Fessenden
University of Massachusetts Medical School

Public Release: 12-Mar-2015
European Radiology
Low breast density in mammography worsens breast cancer prognosis
Very low mammographic breast density worsens the prognosis of breast cancer, according to a recent study from the University of Eastern Finland. Disease free survivals as well as overall life expectancies were significantly shorter in women with very low-density breasts in comparison to women with high-density breast tissue. The lower the breast tissue density, the less fibroglandular tissue there is compared to fat tissue.

Contact: Ritva Vanninen
University of Eastern Finland

Public Release: 12-Mar-2015
Journal of American College of Surgeons
Liver-sparing operation associated with higher survival rates in cancer patients
A surgical approach in which a surgeon removes less than a lobe of the liver in a patient undergoing an operation for liver cancer is associated with lower mortality and complication rates, according to new study results published online as an 'article in press' in the Journal of the American College of Surgeons.
NIH/National Cancer Institute Cancer Center

Contact: Sally Garneski
American College of Surgeons

Public Release: 11-Mar-2015
Molecules in prostate tumors might predict whether RT can help prevent recurrence
A new study has identified a group of molecules in prostate-cancer cells that doctors might one day use to distinguish which patients should be treated with radiation therapy if rising PSA levels indicate their cancer has recurred after surgical removal of the prostate.
NIH/National Cancer Institute

Contact: Darrell E. Ward
Ohio State University Wexner Medical Center

Public Release: 11-Mar-2015
'Quantum jitters' could form basis of evolution, cancer
Duke researchers have discovered 'quantum jitters,' in which DNA's four basic building blocks temporarily change shapes, fooling DNA-replication machinery into making a copying mistake. This shape-shifting is exceedingly rare and only flickers into existence for a thousandth of a second. But these jitters occur with the same frequency as DNA copying mistakes, a hint that this might be the basis of the genetic mutations that drive evolution and diseases like cancer.
National Institutes of Health, Agilent Thought Leader Award

Contact: Karl Bates
Duke University

Public Release: 11-Mar-2015
Tetanus shot improves patient survival with brain tumor immunotherapy
An innovative approach using a tetanus booster to prime the immune system enhances the effect of a vaccine therapy for lethal brain tumors, dramatically improving patient survival, according to a study led by Duke Cancer Institute researchers.
NIH/National Institute of Neurological Disorders and Stroke, National Institutes of Health

Contact: Sarah Avery
Duke University Medical Center

Public Release: 11-Mar-2015
Cancer Prevention Research
Naproxen plus acid-blocking drug shows promise in preventing bladder cancer
Researchers used the proton pump inhibitor omeprazole, a commonly used acid inhibitor, in combination with naproxen and found it was effective at preventing bladder cancer in an animal model.
NIH/National Cancer Institute

Contact: Nicole Fawcett
University of Michigan Health System

Public Release: 11-Mar-2015
Urging HPV vaccine for boys could protect more people at same price
Whether vaccinating US boys against HPV in addition to girls is worth the cost has been hotly debated. But with HPV-related cancers in men on the rise, and coverage in girls stagnating below the levels needed to ensure that most people are protected, research suggests that devoting a portion of HPV funding to boys -- rather than merely attempting to improve female coverage -- may protect more people for the same price.
National Institutes of Health, National Science Foundation, Duke University

Contact: Robin Ann Smith
Duke University

Public Release: 11-Mar-2015
Journal of Thoracic Oncology
Concurrent chemoradiation treatment at high-volume facilities improves survival for NSCLC
Patients treated with definitive concurrent chemotherapy and radiation therapy for stage III non-small cell lung cancer have longer overall survival when treated by highly experienced facilities, whether or not they are academic or community cancer centers.

Contact: Murry Wynes
International Association for the Study of Lung Cancer

Public Release: 11-Mar-2015
PLOS Pathogens
Deadly to cancer cells only
Parvoviruses can destroy cancer cells and are currently being tested in a preliminary clinical trial to treat malignant brain cancer. For their replication, the viruses need a particular enzyme in the cell. Scientists from the German Cancer Research Center have now discovered that in healthy human cells, parvoviruses are unable to activate this enzyme. In many cases of malignant brain cancer, however, the enzyme is permanently active. As a result, this enables the viruses to replicate and to destroy the cancer cells.

Contact: Dr. Sibylle Kohlstädt
German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)

Public Release: 11-Mar-2015
Nature Communications
Honey, I shrunk the ants: How environment controls size
Until now scientists have believed that the variations in traits such as our height, skin colour, tendency to gain weight or not, intelligence, tendency to develop certain diseases, etc., all of them traits that exist along a continuum, were a result of both genetic and environmental factors. But they didn't know how exactly these things worked together. By studying ants, McGill researchers have identified a key mechanism by which epigenetic factors influence the expression of all of these traits.

Contact: Katherine Gombay
McGill University

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