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Public Release: 16-Feb-2016
Immunity
Wistar scientists show how cancerous cells evade a potent targeted therapy
Researchers at The Wistar Institute have discovered how STAT3 behaves in immature myeloid cells known as myeloid-derived suppressor cells (MDSCs), and they believe they have found the basis for a much more effective method of using STAT3 inhibitors to stop cancer progression in its tracks.
National Institutes of Health

Contact: Ben Leach
bleach@wistar.org
215-495-6800
The Wistar Institute

Public Release: 16-Feb-2016
Cell Metabolism
Running helps mice slow cancer growth
Here's one more benefit of exercise: mice who spent their free time on a running wheel were better able to shrink tumors (a 50 percent reduction in tumor size) compared to their less active counterparts. Researchers found that the surge of adrenaline that comes with a high-intensity workout helped to move cancer-killing immune (NK) cells toward lung, liver, or skin tumors implanted into the mice. The study appears Feb. 16, 2016 in Cell Metabolism.

Contact: Joseph Caputo
jcaputo@cell.com
617-397-2802
Cell Press

Public Release: 16-Feb-2016
Science Signaling
Science Signaling companion articles describe ONC201 mechanism of action
Companion research articles from leading groups at MD Anderson Cancer Center and Fox Chase Cancer Center that describe ONC201's ability to uniquely activate the integrated stress response, a powerful anti-cancer signaling pathway, will appear in the American Association for the Advancement of Science Journal Science Signaling.

Contact: Rohinton Tarapore
rohinton.tarapore@oncoceutics.com
215-966-6115
Oncoceutics, Inc.

Public Release: 16-Feb-2016
Gastroenterology
Colorectal cancer patients need colonoscopy after cancer resection
It is critically important that colorectal cancer patients undergo colonoscopy after surgery to ensure that they do not have a second colon cancer, and to find and remove any additional polyps. According to new recommendations from the U.S. Multi-Society Task Force on Colorectal Cancer, the evidence shows that post-operative colonoscopy is associated with improved overall survival for colorectal cancer patients. Between 0.7 and 7 percent of colorectal cancer patients have a second, concurrent cancer.

Contact: Aimee Frank
media@gastro.org
301-941-2620
American Gastroenterological Association

Public Release: 16-Feb-2016
Oncotarget
Synthetic plant hormones shut down DNA repair in cancer cells
Two drugs that mimic a common plant hormone effectively cause DNA damage and turn off a major DNA repair mechanism, suggesting their potential use as an anti-cancer therapy.
National Institutes of Health, US Department of Defense, Georgetown University

Contact: Karen Teber
km463@georgetown.edu
Georgetown University Medical Center

Public Release: 16-Feb-2016
PLoS Medicine
'Ecologically diverse' breast cancers more likely to be deadly
Breast cancers which are particularly complex and diverse, as judged by a test used in ecology to analyze species of animals and plants, are particularly likely to progress and lead to death, a new study shows. The test could be used in the clinic to assess how likely women's breast cancers are to be aggressive, and to help tailor treatment accordingly.
The Institute of Cancer Research, Breast Cancer Now, Wellcome Trust, Cancer Research UK

Contact: Claire Hastings
chastings@icr.ac.uk
020-715-35380
Institute of Cancer Research

Public Release: 16-Feb-2016
British Journal of Cancer
Male cancer survivors less likely to reproduce
Young male cancer survivors are three times as likely to turn to assisted fertilization to have children as males without a cancer diagnosis. This knowledge makes it possible to develop concrete treatment protocols, which affect fertility to a lesser degree. Measures like preserving sperm before starting treatment can be optimized. Close to 80 percent of those diagnosed during childhood or adolescence will survive their cancer.

Contact: Maria Winther Gunnes
maria.gunnes@uib.no
0047-481-92650
The University of Bergen

Public Release: 16-Feb-2016
Nature Communications
How cancer spreads throughout the body
Fast metastasis and resistance to treatment are characteristic of aggressive types of cancer such as pancreatic cancer and certain kinds of breast cancer. They are also the main causes of cancer-related death, as there is currently no specific treatment available that is able to stop tumours spreading throughout the whole body. Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have now discovered a mechanism that promotes metastasis and causes tumours to become resistant to treatment.

Contact: Katrin Piecha
katrin.piecha@fau.de
49-913-185-70218
University of Erlangen-Nuremberg

Public Release: 16-Feb-2016
Molecular Nutrition and Food Research
Absorption of polyphenolic compounds in mangos shows potential benefits to human health
The absorption, metabolism, and excretion of mango galloyl derivatives have not previously been investigated in humans. In this human pilot trial published in the journal of Molecular Nutrition & Food Research, 11 healthy volunteers consumed 400g/day of mango-pulp for 10 days. The results of this research show that mango has the potential to enhance the diet as a source of gallic acid and gallotannins, which may possess anti-inflammatory and anti-carcinogenic properties.
National Mango Board

Contact: Meghan Flynn
meghan.flynn@wildhive.com
203-667-0241
Wild Hive

Public Release: 15-Feb-2016
Nature Genetics
Discovery lays the foundation to expand personalized chemotherapy for leukemia patients
St. Jude Children's Research Hospital scientists lead a study of how inherited genetic variations in the NUDT15 gene cause serious chemotherapy toxicity; findings point to potential genetics-guided precision medicine.
US National Institutes of Health, Order of St. Francis Foundation, V Foundation for Cancer Research, Danish Childhood Cancer Foundation, Japanese Ministry of Health, National Medical Research Council, Singapore, Children's Cancer

Contact: Frannie Marmorstein
media@stjude.org
901-595-0221
St. Jude Children's Research Hospital

Public Release: 15-Feb-2016
Nano Letters
Light used to measure the 'big stretch' in spider silk proteins
While working to improve a tool that measures the pushes and pulls sensed by proteins in living cells, biophysicists at Johns Hopkins say they've discovered one reason spiders' silk is so elastic: Pieces of the silk's protein threads act like supersprings, stretching to five times their initial length. The investigators say the tool will shed light on many biological events, including the shifting forces between cells during cancer metastasis.
National Science Foundation Physics Frontier Centers, NIh/National Institute of General Medical Sciences , NIh/National Institute of Diabetes and Digestive and Kidney Diseases, American Heart Association

Contact: Catherine Gara
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine

Public Release: 15-Feb-2016
Journal of Clinical Oncology
Interferon not beneficial for most stage III melanoma
Final results for the Sunbelt Melanoma Trial, published online this month in the Journal of Clinical Oncology, show that thanks to current diagnostic techniques, most stage III melanoma patients do not benefit from treatment with interferon.
Schering Oncology Biotech

Contact: Betty Coffman
betty.coffman@louisville.edu
502-852-4573
University of Louisville

Public Release: 15-Feb-2016
Biomolecules
Aerobic fitness may protect liver against chronic alcohol use
According to the Centers for Disease Control and Prevention, excessive alcohol use is responsible for more than 80,000 deaths in the United States each year. Over time, excessive drinking can lead to several chronic conditions, such as fatty liver disease and cirrhosis. Now, a study by University of Missouri School of Medicine researchers shows that aerobic exercise may protect the liver against alcohol-related inflammation and injury.
National Institutes of Health, National Institutes of Health Office of Research Infrastructure Programs, US Department of Veterans Affairs

Contact: Jeff Hoelscher
hoelscherj@missouri.edu
573-884-1608
University of Missouri-Columbia

Public Release: 14-Feb-2016
2016 AAAS Annual Meeting
Dr. Stan Riddell, an innovator in cancer immunotherapy at Fred Hutch, to present at AAAS annual meeting
Dr. Stanley Riddell, an immunotherapy researcher and oncologist at Seattle's Fred Hutchinson Cancer Research Center, will present an update on new adoptive T-cell strategies for cancer at the AAAS annual meeting Feb. 14. His presentation will be part of a symposium on the promise and progress of T-cell therapy to fight human diseases. For more than 25 years, Riddell has pioneered experimental therapies that modify and empower the immune system to effectively treat cancers and infectious diseases.
Juno Therapeutics

Contact: Sandy Van
svan2@fredhutch.org
808-526-1708
Fred Hutchinson Cancer Research Center

Public Release: 14-Feb-2016
2016 AAAS Annual Meeting
Progress in fighting cancer and infections with T cell therapy
The quest to bring immunotherapy into widespread clinical use against cancer and infectious diseases has made great strides in recent years. For example, clinical trials of adoptive T cell therapy are yielding highly promising results. The latest progress is being reported at AAAS 2016 by three international leaders in the field: Professor Dirk Busch, Technical University of Munich; Professor Chiara Bonini, San Raffaele Scientific Institute; and Professor Stanley Riddell, Fred Hutchinson Cancer Research Center.
German Research Foundation, Institute of Advanced Study, Juno Therapeutics

Contact: Patrick Regan
patrick.regan@tum.de
49-162-427-9876
Technical University of Munich (TUM)

Public Release: 14-Feb-2016
Stem Cell Reports
Making cancer-fighting cells in the lab
Scientists reprogram human invariant natural killer T cells to induced pluripotent stem cells, which were then differentiated back to iNKT cells that showed stronger activity than the original iNKT cells. This study shows iPS cell technology can be used to recover immune cells that have weakened immune activity.
Japanese Ministry of Education, Culture, Sports, Science and Technology, Aichi Cancer Research Foundation, Takeda Science Foundation, The National Cancer Center Research and Development Fund, Daiwa Securities Health Foundation

Contact: Peter Karagiannis
peter@cira.kyoto-u.ac.jp
81-753-667-005
Center for iPS Cell Research and Application - Kyoto University

Public Release: 12-Feb-2016
Nature Communications
Gene previously observed only in brain is important driver of metastatic breast cancer
Scientists from The Wistar Institute have shown that one gene that was once thought only to be found in the brain is also expressed in breast cancer and helps promote the growth and spread of the disease. Additionally, they showed how a version of the gene with edited RNA prevents metastasis.
National Institutes of Health, Doctors Cancer Foundation, Breast Cancer Alliance, W. W. Smith Foundation, Edward Mallinckrodt Jr. Foundation, ACS-IRG, National Natural Science Funds, Macular Vision Research Foundation

Contact: Ben Leach
bleach@wistar.org
215-495-6800
The Wistar Institute

Public Release: 12-Feb-2016
PLOS Genetics
Genome studies can help identify lifestyle risks for diseases
A type of study commonly used to pinpoint genetic variants associated with diseases can also be used to identify the lifestyle predictors that increase the risk of a disease -- something that is often overlooked in genetic studies

Contact: Simon Davies
simon.l.davies@bristol.ac.uk
01-179-288-086
University of Bristol

Public Release: 12-Feb-2016
Clinical Cancer Research
Study finds mechanism by which obesity promotes pancreatic and breast cancer
Massachusetts General Hospital investigators may have uncovered a novel mechanism behind the ability of obesity to promote cancer progression.
National Institutes of Health, US Department of Defense, Lustgarten Foundation, Warshaw Institute for Pancreatic Cancer Research, Foundation for Science and Technology of Portugal

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital

Public Release: 12-Feb-2016
Nano Letters
New nanotechnology detects biomarkers of cancer
Researchers at Wake Forest Baptist Medical Center have developed a new technology to detect disease biomarkers in the form of nucleic acids, the building blocks of all living organisms.
National Institutes of Health, The Dr. Arthur and Bonnie Ennis Foundation, 3M Non-tenured Faculty Award

Contact: Marguerite Beck
marbeck@wakehealth.edu
336-716-2415
Wake Forest Baptist Medical Center

Public Release: 11-Feb-2016
Cell
DNA breaks in nerve cells' ancestors cluster in specific genes
Study reveals new avenue for thinking about brain development, brain tumors and neurodevelopmental/psychiatric diseases.

Contact: Kristen Dattoli
kristen.dattoli@childrens.harvard.edu
617-919-3141
Boston Children's Hospital

Public Release: 11-Feb-2016
Science Translational Medicine
Younger T cells may improve immunotherapy for children's cancer
Pediatric oncologists have investigated techniques to improve and broaden a novel personalized cell therapy to treat children with cancer. The researchers say a patient's outcome may be improved if clinicians select specific subtypes of T cells to attack diseases like acute lymphoblastic leukemia and lymphoma.
Leukemia and Lymphoma Society, Weinberg Funds, Cookies for Kids' Cancer, Stand Up to Cancer-St. Baldrick's Pediatric Dream Team Translational Research Grant

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia

Public Release: 11-Feb-2016
Scientific Reports
Plant extract shows promise in treating pancreatic cancer
A natural extract derived from India's neem tree could potentially be used to treat pancreatic cancer, according to a new study in the journal Scientific Reports.

Contact: Veronique Masterson
veronique.masterson@ttuhsc.edu
915-215-4858
Texas Tech University Health Sciences Center El Paso

Public Release: 11-Feb-2016
JAMA Oncology
JAMA Oncology: An expert opinion on how to address the skyrocketing prices of cancer drugs
Many patients with cancer find themselves in great financial distress, in part because the costs of cancer-fighting drugs are skyrocketing. Is it possible to create public policy that will rein in these prices and cut patients' out-of-pocket costs? Not without significant tradeoffs that could reduce patients' access to some cancer medications, says physician, cancer researcher and health economist Dr. Scott Ramsey in a JAMA Oncology editorial.

Contact: Sandy Van
svan2@fredhutch.org
808-526-1708
Fred Hutchinson Cancer Research Center

Public Release: 11-Feb-2016
Nature Medicine
The CNIO finds a potential therapy for the most aggressive type of lung cancer in preclinical models
The specific combination of the drugs dasatinib and demcizumab impairs the growth of KRAS-driven lung tumors, the most aggressive sub-type and with the lowest survival rates. The research was conducted on mouse models and samples of human tumors. The experts are confident they can soon start clinical trials which will make it possible to transfer the discoveries to cancer patients. The results will be made public this week in 'Nature Medicine.'

Contact: Vanessa Pombo
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncológicas (CNIO)

Showing releases 1276-1300 out of 1417.

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