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Showing releases 1276-1300 out of 1312.

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Public Release: 10-Mar-2015
New Journal of Physics
Fractal patterns may uncover new line of attack on cancer
Studying the intricate fractal patterns on the surface of cells could give researchers a new insight into the physical nature of cancer, and provide new ways of preventing the disease from developing.

Contact: Michael Bishop
Institute of Physics

Public Release: 10-Mar-2015
Cancer Cell
Study explains control of cell metabolism in patient response to breast cancer drugs
Researchers identify a control mechanism for glutamine uptake in breast cancer cells and its importance for response to select chemotherapies.
National Institutes of Health

Contact: Susan Gammon
Sanford-Burnham Prebys Medical Discover Institute

Public Release: 10-Mar-2015
Cancer Immunology Research
Engineered cells could help tackle the third most common cancer in Chinese males
Researchers at the University of Birmingham believe that a new method of genetically engineering immune cells could lead to improved treatment of nasopharyngeal carcinoma patients.
Cancer Research UK Senior Cancer Fellowship Award, Hong Kong Cancer Fund

Contact: Luke Harrison
University of Birmingham

Public Release: 10-Mar-2015
Scientists show proteins critical in day-night cycles also protect cells from mutations
New research from The Scripps Research Institute shows that two proteins critical for maintaining healthy day-night cycles also protect against mutations that could lead to cancer. The new study shows that the two proteins have an unexpected role in DNA repair, possibly protecting cells from cancer-causing mutations triggered by UV radiation.
Searle Scholars Fund, Sidney Kimmel Foundation for Cancer Research, Lung Cancer Research Foundation, NIH/National Institute of General Medical Sciences, NIH/National Institute on Aging, NIH/National Institute of Diabetes, Digestive and Kidney Diseases

Contact: Madeline McCurry-Schmidt
Scripps Research Institute

Public Release: 10-Mar-2015
American Journal of Gastroenterology
Regenstrief study finds natural language processing accurately tracks colonoscopy quality
An accurate system for tracking the quality of colonoscopies and determining the appropriate intervals between these procedures could contribute to both better health outcomes and lower costs. Clinician-researchers from the Regenstrief Institute have created and tested such a system in the nation's first multiple institution colonoscopy quality measurement study utilizing natural language processing and report that it is as accurate but less expensive than human review.
VA Merit Review Grant, American Society for Gastrointestinal Endoscopy Covidien Senior Investigator Mentoring and Career Development Awards, Mamlin-McDonald Biomedical Informatics Fellowship, Regenstrief Institute Innovations Award

Contact: Cindy Fox Aisen
Indiana University

Public Release: 10-Mar-2015
International Journal of Radiation Oncology • Biology • Physics
Clinical trial suggests combination therapy is best for low-grade brain tumors
New clinical-trial findings provide further evidence that combining chemotherapy with radiation therapy is the best treatment for people with a low-grade form of brain cancer.
NIH/National Cancer Institute

Contact: Darrell E. Ward
Ohio State University Wexner Medical Center

Public Release: 9-Mar-2015
Nature Nanotechnology
Innovative light therapy reaches deep tumors
Using a mouse model of cancer, researchers at Washington University School of Medicine in St. Louis have devised a way to apply light-based therapy to deep tissues never before accessible. Instead of shining an outside light, they delivered light directly to tumor cells, along with a photosensitive source of free radicals that can be activated by the light to destroy cancer. And they accomplished this using materials already approved for use in cancer patients.
National Institutes of Health, National Science Foundation

Contact: Julia Evangelou Strait
Washington University School of Medicine

Public Release: 9-Mar-2015
Cancer Cell
Childhood leukemia study reveals disease subtypes, new treatment option
A new study of acute lymphoblastic leukemia (ALL), a blood cancer that primarily affects young children, has revealed that the disease has two distinct subtypes, and provides preliminary evidence that about 13 percent of ALL cases may be successfully treated with targeted drugs that have proved highly effective in the treatment of lymphomas in adults.
National Institutes of Health, NIH/National Cancer Institute, Hyundai Hope on Wheels, St. Baldrick's Foundation, Leukemia and Lymphoma Society, Tucker's Toy Box Foundation, William Lawrence and Blanche Hughes Foundation, and others

Contact: Pete Farley
University of California - San Francisco

Public Release: 9-Mar-2015
Radiation plus immunotherapy combo revs up immune system to better attack melanoma, Penn study suggests
Treating metastatic melanoma with a triple threat --including radiation therapy and two immunotherapies that target the CTLA4 and PD-1 pathways -- could elicit an optimal response in more patients, one that will boost the immune system's attack on the disease, suggests a new study from a multidisciplinary team of researchers from Penn's Abramson Cancer Center published today in Nature.
Abramson Cancer Center, Melanoma Research Alliance, NIH/National Cancer Institute, Department of Defense and Basser Research Center for BRCA

Contact: Steve Graff
University of Pennsylvania School of Medicine

Public Release: 9-Mar-2015
JAMA Internal Medicine
Vegetarian diet linked to lower risk of colorectal cancers
Eating a vegetarian diet was associated with a lower risk of colorectal cancers compared with nonvegetarians in a study of Seventh-Day Adventist men and women, according to an article published online by JAMA Internal Medicine.

Contact: Calvin Naito
The JAMA Network Journals

Public Release: 9-Mar-2015
Nature Methods
New gene sequencing technology like a high-powered microscope
A new gene sequencing technology known as 'Capture Sequencing' allows us to explore the human genome at a much higher resolution than ever before, with revolutionary implications for research and cancer diagnosis.

Contact: Alison Heather
Garvan Institute of Medical Research

Public Release: 9-Mar-2015
Nature Genetics
Fifteen new breast cancer genetic risk 'hot-spots' revealed
Scientists have discovered another 15 genetic 'hot-spots' that can increase a woman's risk of developing breast cancer, according to research published today in Nature Genetics.
Cancer Research UK, European Union, Canadian Institutes of Health Research, Ministry of Economic Development, Innovation and Export Trade of Quebec, National Institutes of Health

Contact: Liz Smith
Cancer Research UK

Public Release: 9-Mar-2015
Breast cancer risk may be increased in women who have first-degree relatives with a history of prostate cancer
Having a family history of prostate cancer among first-degree relatives may increase a woman's risk of developing breast cancer.

Contact: Evelyn Martinez

Public Release: 9-Mar-2015
The EMBO Journal
Cancer-linked protein helps control fate of intestinal stem cells
An international group of researchers has shown that a regulatory protein involved in controlling how cancer spreads through the body also influences the fate of stem cells in the intestine of mice. The results show that the Snai1 protein plays an important role in deciding the fate of intestinal stem cells and the different functions that these cells can adopt.

Contact: Barry Whyte

Public Release: 9-Mar-2015
DNA and Cell Biology
Viagra in combination with new drugs can have anti-cancer, antibacterial, and therapeutic effects
Chaperone proteins play an important role in protein folding in human cells and in bacteria and are promising new targets for drugs to treat cancer and Alzheimer's disease and for novel antiviral drugs and antibiotics. How existing drugs such as Viagra or Cialis and a derivative of the drug Celebrex, for example, can reduce the activity of a specific chaperone protein, with the potential for anti-tumor and anti-Alzheimer's disease effects, is described in a Review article in DNA and Cell Biology.

Contact: Kathryn Ryan
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 9-Mar-2015
Understanding of cell enzyme flipped on its head
Researchers from Manchester, working with scientists in California, have found that certain molecules long thought to promote cancer growth, in fact suppress tumors, suggesting that therapeutic approaches should aim to restore, rather than block, their activity.

Contact: Jamie Brown
University of Manchester

Public Release: 9-Mar-2015
Journal of Clinical Investigation
From brain tumors to memory: A very multifunctional protein
A protein called BAI1 involved in limiting the growth of brain tumors is also critical for spatial learning and memory, researchers have discovered. BAI1 is part of a regulatory network neuroscientists think is connected with autism spectrum disorders.
NIH/National Cancer Institute, NIH/National Institute of Neurological Disorders and Stroke, Southeastern Brain Tumor Foundation, St. Baldricks

Contact: Quinn Eastman
Emory Health Sciences

Public Release: 9-Mar-2015
Nature Communications
Researchers map 'genomic landscape' of childhood adrenocortical tumors for the first time
In an advance that could lead to better identification of malignant pediatric adrenocortical tumors, and ultimately to better treatment, researchers have mapped the 'genomic landscape' of these rare childhood tumors. Their genomic mapping has revealed unprecedented details, not only of the aberrant genetic and chromosomal changes that drive the cancer, but the sequence of those changes that trigger it.
Washington University Pediatric Cancer Genome Project, Kay Jewelers, National Institutes of Health, NIH/National Cancer Institute, ALSAC

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

Public Release: 9-Mar-2015
Nature Cell Biology
Hippo 'crosstalk' may be vital to tumor suppression
Scientists at The University of Texas MD Anderson Cancer Center have discovered new information about a key pathway known as Hippo, a metaphoric name referencing its link to tissue 'overgrowth.' The Hippo pathway has been shown to regulate cell death and cell growth, thus playing a role in the development or prevention of tumors.

Contact: Ron Gilmore
University of Texas M. D. Anderson Cancer Center

Public Release: 9-Mar-2015
The Journal of Mental Health
African-American cancer patients' depression symptoms under-recognized, CWRU study finds
Case Western Reserve University nurse scientist Amy Zhang, who has long examined quality-of-life issues in cancer patients, wondered whether depression in African-American cancer patients has been under-recognized for treatment.Accurately assessing depression in cancer patients is difficult in general because the physical symptoms of cancer and depression -- low energy, lack of sleep and loss of appetite -- are so similar.
NIH/National Institute of Cancer

Contact: Susan Griffith
Case Western Reserve University

Public Release: 8-Mar-2015
ENDO 2015: The 97th Annual Meeting & EXPO in San Diego, CA
Advanced thyroid cancer responds to targeted therapy with sunitinib
In patients with advanced thyroid cancer, sunitinib, a drug approved for treatment of several other cancers, showed significant cancer-fighting activity t, a new phase 2 clinical trial has found. Results of the single-center study will be presented Sunday at the Endocrine Society's 97th annual meeting in San Diego.

Contact: Aaron Lohr
The Endocrine Society

Public Release: 7-Mar-2015
ENDO 2015: The 97th Annual Meeting & EXPO in San Diego, CA
After breast cancer diagnosis, risk of thyroid cancer goes up
Breast cancer survivors are at increased risk of developing thyroid cancer, especially within five years of their breast cancer diagnosis, according to a new analysis of a large national database. The study results will be presented Thursday at the Endocrine Society's 97th annual meeting in San Diego.

Contact: Aaron Lohr
The Endocrine Society

Public Release: 7-Mar-2015
Scent-trained dog detects thyroid cancer in human urine samples
A trained scent dog accurately identified whether patients' urine samples had thyroid cancer or were benign (noncancerous) 88.2 percent of the time, according to a new study, to- be presented Friday at the Endocrine Society's 97th annual meeting in San Diego.

Contact: Aaron Lohr
The Endocrine Society

Public Release: 6-Mar-2015
Clinical and Translational Medicine
Review article provides new insights on how tumors metastasize
In a review article recently published in the journal Clinical and Translational Medicine, researchers from Boston University School of Medicine shed new light on the underlying processes of tumor metastasis and highlight the role of epigenetics in this process.

Contact: Gina DiGravio
Boston University Medical Center

Public Release: 6-Mar-2015
Nature Genetics
Chromosomal rearrangement is the key to progress against aggressive infant leukemia
The St. Jude Children's Research Hospital -- Washington University Pediatric Cancer Genome Project reports that a highly aggressive form of leukemia in infants has surprisingly few mutations beyond the chromosomal rearrangement that affects the MLL gene. The findings suggest that targeting the alteration is likely the key to improved survival. The research appeared online ahead of print this week in the scientific journal Nature Genetics.
Kay Jewelers, National Institutes of Health, Swedish Childhood Cancer Society, Swedish Research Council, Swedish Cancer Society, BioCARE, Gunnar Nilsson Cancer Foundation, ALSAC

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

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