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Showing releases 1276-1300 out of 1352.

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Public Release: 12-Jan-2016
Nature Structural & Molecular Biology
Neils help removing epigenetic marks
Scientists at the Institute of Molecular Biology in Mainz have identified a missing piece of the puzzle in understanding how epigenetic marks are removed from DNA. The research on DNA demethylation sheds new light on a fundamental process that is important in development and diseases such as cancer.

Contact: Dr. Ralf Dahm
Johannes Gutenberg Universitaet Mainz

Public Release: 12-Jan-2016
Experts call for more tailored liver cancer care in developing countries
International liver cancer guidelines could be preventing patients from getting life-saving treatments in developing countries, according to a new study published in the journal Heliyon. The authors of the research are calling for treatment guidelines that are more tailored to developing countries, to help save lives.

Contact: Mary Beth O'Leary

Public Release: 12-Jan-2016
Stem Cell Reports
Scientists identify molecule that appears to fuel deadly genetic illness
Researchers have identified a molecular target and experimental treatment strategy for DNA repair defects behind Fanconi anemia -- a complex genetic disorder responsible for birth anomalies, organ damage, anemia and cancer. The findings, published Jan. 12, 2016, in Stem Cell Reports, also create a bit of molecular intrigue. It involves how cells used in the study -- which still had the Fanconi anemia (FA) DNA repair defect -- were able to recover and grow normally after targeted treatment.

Contact: Nick Miller
Cincinnati Children's Hospital Medical Center

Public Release: 12-Jan-2016
Source of stem cells used for bone marrow failure treatment varies worldwide
Ayami Yoshimi, M.D., Ph.D., of the University of Freiburg, Germany, and colleagues examined the use of peripheral blood stem cells and bone marrow as stem cell sources for hematopoietic stem cell transplantation in patients with bone marrow failure worldwide and factors associated with the use of each stem cell source. The study appears in the Jan. 12 issue of JAMA.

Contact: Ayami Yoshimi, M.D., Ph.D.
The JAMA Network Journals

Public Release: 12-Jan-2016
Catheterization and Cardiovascular Interventions
SCAI releases expert consensus for cardio-oncology patients treated in cardiac catheterization labs
The Society for Cardiovascular Angiography and Interventions (SCAI) has released an expert consensus statement providing cardiologists, oncologists and internal medicine physicians guidance for treating patients facing concomitant cardiovascular disease and cancer. The document was released in Catheterization and Cardiovascular Interventions, and is endorsed by the Cardiological Society of India and Sociedad Latino Americana de Cardiologia Intervencionista. The paper aims to increase the competency of cardiovascular professionals providing care to cancer patients.

Contact: Kimberly Brown
Society for Cardiovascular Angiography and Interventions

Public Release: 11-Jan-2016
What's in store for survivors of childhood cancers that affect vision?
Little is known about the long-term health of survivors of childhood cancers that affect vision, but two new studies provide valuable insights that could impact patient care and follow-up. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society.

Contact: Dawn Peters

Public Release: 11-Jan-2016
Proceedings of the National Academy of Sciences
PNAS: Childhood leukemias forged by different evolutionary forces than in older adults
A University of Colorado Cancer Center paper published in the Proceedings of the National Academy of Sciences shows that the evolutionary force of genetic drift contributes to the ability of cancerous cells to overtake populations of healthy cells in young children. In contrast, genetic drift contributes almost not at all to leukemia formation in adults. The finding suggests important new avenues for leukemia treatment in very young patients.
NIH/National Cancer Institute, Linda Crnic Institute for Down Syndrome, Leukemia Lymphoma Society, St. Baldrick's Foundation

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 11-Jan-2016
Annals of Internal Medicine
More research needed on evaluation of dense breasts
A systematic review of the scientific literature on dense breasts by researchers at UC Davis and other institutions has found that determinations of breast density can be unreliable and that as many as 19 percent of women are re-categorized as dense rather than non-dense or vice versa from one mammogram to the next.
Agency for Healthcare Research and Quality

Contact: Dorsey Griffith
University of California - Davis Health System

Public Release: 11-Jan-2016
Annals of Internal Medicine
USPSTF final recommendations on breast cancer screening
The US Preventive Services Task Force published a final recommendation statement on screening for breast cancer following an in-depth review of the science on the benefits and harms of screening mammography, and a detailed review of input received from the public and health care professionals on its 2015 draft recommendation.

Contact: Cara Graeff
American College of Physicians

Public Release: 11-Jan-2016
Future of lung treatment: Malaysian scientists join Harvard team creating safe, effective nano drugs
Scientists from Malaysia are teaming with Harvard University experts to help revolutionize the treatment of lung diseases -- the safe, effective delivery of nanomedicine deep into parts of the lung unreachable using common inhalers. Other Malaysian Institute for Innovative Nanotechnology research pursuits include converting greenhouse gases into an energy source; 'Smart farming' nanosensors; more. The new national nanotech program, initiated through Malaysia's Global Science & Innovation Advisory Council, aims to make a macro impact in health, energy, environment, agriculture, electronics.

Contact: Terry Collins
Malaysian Industry-Government Group for High Technology

Public Release: 11-Jan-2016
Nature Methods
Linking gene expression and DNA methylation in single cells
A new single-cell genomics protocol allows researchers to study links between DNA modifications (methylation) and the activity of a gene. The method is the first to enable parallel profiling of the transcriptome and epigenome of a single cell. The researchers used the method to reveal new epigenome-transcriptome associations relevant to the regulation of pluripotency in mouse embryonic stem cells; The method is potentially transformative for epigenetics research, as it reveals unprecedented detail of the epigenetic control of genes.
Biotechnology and Biological Sciences Research Council, Wellcome Trust, European Molecular Biology Laboratory, Medical Research Council, European Commission

Contact: Mary Todd Bergman
European Molecular Biology Laboratory - European Bioinformatics Institute

Public Release: 11-Jan-2016
Cancer Cell
McMaster researchers reveal predictive staircase to leukemia
In the paper published today by the scientific journal Cancer Cell, the researchers detail how they have been able to fingerprint myelodysplastic syndromes, a state for blood cells that turns into acute myeloid leukemia cancer in approximately 30 percent of patients.
Canadian Institutes of Health Research, Canadian Cancer Society Research Institute

Contact: Veronica McGuire
McMaster University

Public Release: 11-Jan-2016
Annals of Internal Medicine
Making a safe procedure even safer
In a comprehensive modeling study, researchers from UC Davis and other institutions have found that breast cancer screening with digital mammography poses only a small risk of radiation-induced breast cancer for most women.
Agency for Healthcare Research and Quality, NIH/National Cancer Institute

Contact: Dorsey Griffith
University of California - Davis Health System

Public Release: 11-Jan-2016
Biotech Showcase
InSilico Medicine presents advances in deep learning for drug discovery and aging research
On Tuesday, Jan. 12, at 5:15 p.m. US ET, InSilico Medicine will present an update on recent advances in applying signaling pathway activation analysis and deep learning to drug discovery and drug repurposing for age-related diseases at the Biotech Showcase in San Francisco.

Contact: Qingsong Zhu
InSilico Medicine, Inc.

Public Release: 11-Jan-2016
Annals of Internal Medicine
New analyses confirms biennial mammography starting at age 50 is optimal for average women
New and comprehensive analyses from six independent research teams examining breast cancer screening intervals have produced a unanimous finding -- that mammography screening every two years for average risk women ages 50 to 74 offers a favorable balance of benefits to harm.
National Institutes of Health

Contact: Karen Teber
Georgetown University Medical Center

Public Release: 11-Jan-2016
Journal of Thoracic Oncology
Stage increase in lung cancer more frequent after open vs. closed thoracic surgery
An increase in the stage of non-small cell lung cancer due to cancer positive lymph node discovery was more common following open chest surgery for lung lobe removal of early stage lung cancer compared to the closed chest procedure known as video assisted thoracic surgery.

Contact: Jeff Wolf
International Association for the Study of Lung Cancer

Public Release: 11-Jan-2016
Applied Physics Letters
Two-in-one packaging may increase drug efficacy and reduce side effects
Researchers have developed a speedy, controllable way to get two or more ingredients into the same tiny capsule and only have them mix when triggered by a signal like vibrations or heat.

Contact: Jason Socrates Bardi
American Institute of Physics

Public Release: 11-Jan-2016
Researchers find shared molecular response to tobacco smoke and indoor air pollution
Exposure to certain household air pollutants may cause some of the same molecular changes as smoking cigarettes.
NIH/National Institute of Environmental Health Sciences, NIH/National Cancer Institute Intramural Research Program

Contact: Gina DiGravio
Boston University Medical Center

Public Release: 11-Jan-2016
Molecular Oncology
Blood test that monitors dead cancer cell DNA better at tracking spread of melanoma
Physicians treating patients with metastatic melanoma -- one of the most aggressive forms of skin cancer -- may soon have a superior tool in their efforts to closely track the disease.

Contact: David March
NYU Langone Medical Center / New York University School of Medicine

Public Release: 11-Jan-2016
Nature Cell Biology
Study reveals potential therapy targets for triple-negative breast cancer
In cancer, cell signaling pathways are the critical chain of events that can either quash or quicken disease progression.

Contact: Ron Gilmore
University of Texas M. D. Anderson Cancer Center

Public Release: 11-Jan-2016
Public Health Reports
One hookah tobacco smoking session delivers 25 times the tar of a single cigarette
As cigarette smoking rates fall, more people are smoking tobacco from hookahs -communal pipes that enable users to draw tobacco smoke through water. A new meta-analysis led by the University of Pittsburgh School of Medicine shows that hookah smokers are inhaling a large load of toxicants.
NIH/National Cancer Institute

Contact: Allison Hydzik
University of Pittsburgh Schools of the Health Sciences

Public Release: 11-Jan-2016
Painkiller tapped to become future cancer-killer
Diclofenac, a common painkiller, has significant anti-cancer properties, according to researchers from the Repurposing Drugs in Oncology project. Like other drugs examined by the ReDO project, diclofenac is cheap and readily accessible -- and as it's already present in many medicine cabinets, it has been carefully tested.

Contact: Audrey Nailor

Public Release: 10-Jan-2016
2016 Genitourinary Cancers Symposium
Even after anti-androgen therapy, docetaxel remains useful in prostate cancer
A study presented at the 2016 Genitourinary Cancers Symposium shows that 40 percent of patients with castration-resistant metastatic prostate cancer (mCRPC) treated with docetaxel following abiraterone had at least 50 percent reduction in prostate specific antigen (PSA), demonstrating the activity of this drug sequencing.
Genitourinary Cancers Symposium 2016

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 8-Jan-2016
Racial disparity lies at intersection of HIV, Hodgkin lymphoma
Among HIV-positive patients with Hodgkin lymphoma, a new study finds that blacks are significantly less likely than whites to receive treatment for the cancer, even though chemotherapy saves lives.
American Society of Hematology

Contact: David Orenstein
Brown University

Public Release: 8-Jan-2016
New report finds no significant increase in health risks for 1960s Project SHAD veterans
Veterans who participated in a series of tests during the 1960s known as Project SHAD (Shipboard Hazard and Defense) show no significant increase in adverse health outcomes, specific causes of death, or death rates compared with a similar group of veterans who were not involved in the tests, says a new report from a committee of the National Academies of Sciences, Engineering, and Medicine.

Contact: Molly Galvin
National Academies of Sciences, Engineering, and Medicine

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