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Public Release: 7-Mar-2016
Nature Genetics
Novel molecular processes controlling key genes in prostate cancer uncovered
Researchers at Sweden's Karolinska Institutet and the University of Oulu in Finland have elucidated gene regulatory mechanisms that can explain how known genetic variants influence prostate cancer risk. The findings, published in the journal Nature Genetics, reveal widespread deregulation of androgen receptor function, a key player in prostate cancer.
Swedish Cancer Society, Swedish Research Council, The Academy of Finland

Contact: KI Press Office
Karolinska Institutet

Public Release: 7-Mar-2016
Cancer Discovery
Blood test may give early warning of skin cancer relapse
A blood test may be able to sound early warning bells that patients with advanced melanoma skin cancer are relapsing, according to a study published in the journal Cancer Discovery today.
Cancer Research UK

Contact: Emily Head
Cancer Research UK

Public Release: 7-Mar-2016
Nature Genetics
Skin cancer: To each tumor its particularities, to each tumor its treatment
90 percent of the population are at risk to develop a skin cancer, called basal cell carcinoma, one day. Although common, this cancer is rarely fatal and has until now been little studied. But geneticists sequenced the DNA of these skin tumors, in order to determine the genes that are responsible for the cancerogenesis. Their discovery of new cancer genes that cause BCC can pave the way for new treatment methods personalized for each tumor.

Contact: Sergey Nikolaev
Université de Genève

Public Release: 7-Mar-2016
Journal of Clinical Oncology
Where prostate cancer spreads in the body affects survival time
In the largest analysis of its kind, researchers at the Duke Cancer Institute and other top cancer centers have found that the organ site where prostate cancer spreads has a direct impact on survival.
National Institutes of Health, US Department of Defense

Contact: Sarah Avery
Duke University Medical Center

Public Release: 7-Mar-2016
Developmental Cell
How cancer cells fuel their growth
MIT scientists surprised to find that amino acids, not sugar, supply most building blocks for tumor cells.
National Institutes of Health, Burroughs Wellcome Fund, Damon Runyon Cancer Research Foundation

Contact: Sarah McDonnell
Massachusetts Institute of Technology

Public Release: 7-Mar-2016
Journal of Clinical Oncology
Quality of life not notably better for women choosing double mastectomy
Contralateral prophylactic mastectomies were associated with slightly higher satisfaction in women's perception of how their breasts looked and felt, but primarily among women whose mastectomies were followed by reconstructive surgery.
Plastic Surgery Foundation

Contact: Sarah Avery
Duke University Medical Center

Public Release: 7-Mar-2016
Canadian Medical Association Journal
Lung cancer screening: New Canadian guideline
Adults aged 55-74 years who are at high risk of lung cancer -- current or former smokers (i.e., have quit within the past 15 years) with at least a 30 pack-year history or more -- should be screened annually up to three times using low-dose computed tomography (CT), according to a new guideline from the Canadian Task Force on Preventive Health Care published in Canadian Medical Association Journal.
Public Health Agency of Canada, Health Canada/Canadian Partnership Against Cancer

Contact: Kim Barnhardt
Canadian Medical Association Journal

Public Release: 7-Mar-2016
Nature Structural & Molecular Biology
CNIO scientists have discovered a code of signals that regulates genome duplication
The balance between two modifications in proteins -- ubiquitination and SUMOylation -- regulates cellular DNA copying. The USP7 protein travels with the machinery required to copy the DNA and favours, through these modifications, genome duplication during cellular division. The results bring into question the anti-tumor potential of USP7 inhibitors, as the activity of this protein is also essential for healthy cells. The paper is being published today in the journal Nature Structural & Molecular Biology.

Contact: Vanessa Pombo
Centro Nacional de Investigaciones Oncológicas (CNIO)

Public Release: 7-Mar-2016
Nature Methods
Immunology meets single-cell sequencing
A new single-cell genomics method helps determine T-cell receptor sequences and extrapolate their response to disease. The technique will help research into immune response, autoimmune disease, cancer and vaccination. Uptake enables sequencing-based understanding of which T-cell receptors recognize specific invaders -- knowledge that could be used to speed up diagnosis.
European Research Council, Lister Institute for Preventative Medicine, EMBL, Wellcome Trust Sanger Institute

Contact: Mary Todd Bergman
European Molecular Biology Laboratory - European Bioinformatics Institute

Public Release: 7-Mar-2016
Journal of Thoracic Oncology
Clinician communication reduced distress related to the detection of incidental nodules
A cross-sectional survey showed a quarter of patients with detected incidental pulmonary nodules experienced significant distress related to the nodule. Detailed clinician communication increased patient knowledge, relieved distress, and improved patient experience.

Contact: Jeff Wolf
International Association for the Study of Lung Cancer

Public Release: 7-Mar-2016
Proceedings of the National Academy of Sciences
Team finds new approach to curbing cancer cell growth
Using a new approach, scientists at The Scripps Research Institute and collaborating institutions have discovered a novel drug candidate that could be used to treat certain types of breast cancer, lung cancer and melanoma.
National Institutes of Health, PanCAN-AACR Pathway to Leadership Award, Damon Runyon Cancer Research Foundation/Dale F. Frey Award for Breakthrough Scientists, and Concern Foundation/Conquer Cancer Now Award

Contact: Madeline McCurry-Schmidt
Scripps Research Institute

Public Release: 7-Mar-2016
Cancer Cell
VCU scientists work to bring about a new treatment for rare childhood cancer
Neuroblastoma is a rare cancer that develops in very early forms of nerve cells in the embryo or fetus, and it accounts for the most pediatric deaths for any tumor outside of the brain. The most lethal form of this tumor is often associated with amplification of the gene MYCN, and now VCU scientists may have developed a combination therapy that uses this gene to kill the cancer, instead of making it grow.
Rally Foundation for Childhood Cancer Research and Truth 365, Alex's Lemonade Stand, Wipe Out Kids Cancer, The Wellcome Trust, George and Lavina Blick Research Fund, VCU Massey Cancer Center, National Institutes of Health

Contact: John Wallace
Virginia Commonwealth University

Public Release: 7-Mar-2016
High white blood cell ratio linked to recurrence risk in early stage breast cancer
A high ratio of two types of immune system cell is linked to an increased risk of disease recurrence after a diagnosis of early stage breast cancer, finds the first study of its kind, published on the eve of international Women's Day (March 8) in the online journal ESMO Open.

Contact: Caroline White

Public Release: 6-Mar-2016
Archives of Disease in Childhood
UK diagnoses children's kidney cancer at a later stage than Germany
THE UK diagnoses Wilms' tumors -- the most common children's kidney cancer -- when they are larger and more advanced compared with those diagnosed in Germany, according to a Cancer Research UK-funded study published in the journal Archives of Disease in Childhood, today.
Cancer Research UK

Contact: Emily Head
Cancer Research UK

Public Release: 4-Mar-2016
Scientific Reports
Moffitt Cancer Center researchers target specific protein associated with poor survival and treatment
Glioblastoma multiformeis a highly aggressive brain tumor with low survival rates, with newly diagnosed patients surviving a median of 14 months and recurrent patients surviving a median of only 3 to 9 months. New therapeutic targets and biomarkers for prognosis are urgently needed. Moffitt Cancer Center researchers recently reported that expression of the protein BIRC3 is associated with poor survival and recurrent disease in GBM patients; and therefore may be a good therapeutic target.

Contact: Lisa Chillura
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 4-Mar-2016
Cancer Epidemiology, Biomarkers & Prevention
Dietary glycemic index linked to lung cancer risk in select populations
Consuming a diet with a high glycemic index, a classification of how rapidly carbohydrates elevate blood sugar levels, was independently associated with an increased risk of developing lung cancer in non-Hispanic whites, according to a new epidemiologic study from The University of Texas MD Anderson Cancer Center.

Contact: Clayton R. Boldt, Ph.D.
University of Texas M. D. Anderson Cancer Center

Public Release: 4-Mar-2016
Biomarker tests for molecularly targeted therapies need better evidence, oversight
Potentially useful biomarker tests for molecularly targeted therapies are not being adopted appropriately into clinical practice because of a lack of common evidentiary standards necessary for regulatory, reimbursement, and treatment decisions, says a new report by the National Academies of Sciences, Engineering, and Medicine.

Contact: Molly Galvin
National Academies of Sciences, Engineering, and Medicine

Public Release: 4-Mar-2016
Nature Communications
New insights reported about the Angelina Jolie gene
New research from the Cancer Therapy & Research Center at the UT Health Science Center at San Antonio reveals another function of the breast cancer susceptibility gene BRCA1. This could lead to improved diagnostics and treatment tools for this form of breast cancer.
NIH/National Cancer Institute, Tom C. and Patricia H. Frost Endowment to Advance Cancer Research and Education, Max and Minnie Tomerlin Voelcker Fund, Avon Foundation for Women, Alamo Breast Cancer Foundation, Cancer Therapy & Research Center

Contact: Will Sansom
University of Texas Health Science Center at San Antonio

Public Release: 3-Mar-2016
Stem Cell Reports
MSU discovers a new kind of stem cell
Scientists at Michigan State University have discovered a new kind of stem cell, one that could lead to advances in regenerative medicine as well as offer new ways to study birth defects and other reproductive problems.
National Institutes of Health

Contact: Layne Cameron
Michigan State University

Public Release: 3-Mar-2016
Molecular Cell
PGK1 protein promotes brain tumor formation and cancer metabolism
PGK1, a glycolytic enzyme, has been found to play a role in coordinating cellular processes crucial to cancer metabolism and brain tumor formation, according to results published in today's online issue of Molecular Cell.

Contact: Ron Gilmore
University of Texas M. D. Anderson Cancer Center

Public Release: 3-Mar-2016
Journal of Nutrition
Study shows broccoli may offer protection against liver cancer
Research has shown that eating broccoli three to five times per week can lower the risk of many types of cancers. Consuming a high-fat, high-sugar diet and having excess body fat is linked with the development of nonalcoholic fatty liver disease (NAFLD), which can lead to diseases such as cirrhosis and liver cancer. A new study from the University of Illinois shows that including broccoli in the diet may protect against liver cancer, as well as aid in countering the development of NAFLD.
NIH/National Cancer Institute

Contact: Stephanie Henry
University of Illinois College of Agricultural, Consumer and Environmental Sciences

Public Release: 3-Mar-2016
American Chemical Society 251st National Meeting & Exposition
Plenaries at American Chemical Society meeting will focus on computers in chemistry
Scientists, in four plenary talks, will explore a variety of subjects related to the 'Computers in Chemistry' theme of the 251st National Meeting & Exposition of the American Chemical Society, the world's largest scientific society. The meeting will take place March 13-17 in San Diego.

Contact: Michael Bernstein
American Chemical Society

Public Release: 3-Mar-2016
By cloning mouse neurons, TSRI scientists find brain cells with 100+ unique mutations
Scientists from The Scripps Research Institute are the first to sequence the complete genomes of individual neurons and to produce live mice carrying neuronal genomes in all of their cells. Use of the technique revealed surprising insights into these cells' genomes.
NIH/National Institute on Deafness and Other Communication Disorders, NIH/National Institute of Mental Health, California Institute for Regenerative Medicine, Baxter Family Foundation, Norris Foundation

Contact: Madeline McCurry-Schmidt
Scripps Research Institute

Public Release: 3-Mar-2016
Cell Reports
New vulnerability revealed in blood cancer development
Australian researchers have uncovered a protein that is key to the development of blood cancers caused by a common genetic error.
Victorian Government Operational Infrastructure Support Program, National Health and Medical Research Council, Leukaemia Foundation of Australia, Cancer Council Victoria, Lady Tata Memorial Trust, Estate of Anthony (Toni) Redstone OAM, and others

Contact: Vanessa S Solomon
Walter and Eliza Hall Institute

Public Release: 3-Mar-2016
JAMA Oncology
Cancer expert says public health and prevention measures are key to defeating cancer
Is investment in research to develop new treatments the best approach to controlling cancer? Many people believe that the time is right for another big push to defeat cancer, including President Obama, who called for a major cancer-fighting campaign in his final State of the Union address. But in the latest paper, 'Targeting the Cancer Moonshot' in JAMA Oncology, this kind of effort will never cure cancer without public health and prevention.

Contact: Stephanie Berger
Columbia University's Mailman School of Public Health

Showing releases 1301-1325 out of 1380.

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