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Showing releases 151-175 out of 1246.

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Public Release: 4-Dec-2014
Cell Stem Cell
Approved breast cancer drug offers hope for the treatment of blood disorders
A new study provides an explanation as to why blood cancers are more common in men than in women, revealing that estrogens regulate the survival of stem cells that give rise to blood cancers. Moreover, findings in mice with blood neoplasms suggest that a drug called tamoxifen, which targets estrogen receptors and is approved for treatment of breast cancer, may also be a valuable strategy for blocking the development of blood neoplasms in humans.

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press

Public Release: 4-Dec-2014
Nature Communications
Mini chromosomes that strengthen tumors
Cancers are due to genetic aberrations in certain cells that gain the ability to divide indefinitely. This proliferation of sick cells generates tumors, which gradually invade healthy tissue. Therefore, current therapies essentially seek to destroy cancer cells to stop their proliferation.

Contact: Federico Santoni
federico.santoni@unige.ch
022-379-5719
Université de Genève

Public Release: 4-Dec-2014
Science
Smoking and higher mortality in men
In a new study, published in Science, researchers at Uppsala University demonstrate an association between smoking and loss of the Y chromosome in blood cells. The researchers have previously shown that loss of the Y chromosome is linked to cancer. Since only men have the Y chromosome, these results might explain why smoking is a greater risk factor for cancer among men and, in the broader perspective, also why men in general have a shorter life expectancy.

Contact: Lars Forsberg
lars.forsberg@igp.uu.se
46-707-401-775
Uppsala University

Public Release: 4-Dec-2014
Cell Stem Cell
Female sex hormones can protect against the development of some blood disorders
Estrogens, a major class of female sex hormone, can regulate the activity of the hematopoietic stem cells in the bone marrow and in this way influence the development of some types of leukemia. This is the conclusion of a new study led by researchers at the Centro Nacional de Investigaciones Cardiovasculares and published in the latest edition of the journal Cell Stem Cell.

Contact: Ainhoa Iriberri
airiberri@cnic.es
34-610-295-556
Centro Nacional de Investigaciones Cardiovasculares

Public Release: 4-Dec-2014
Archives of Disease in Childhood
Boosting length of breastfeeding could save NHS more than £40 million every year
Doubling the number of mums who breastfeed for 7-18 months in their lifetime and helping others to continue for at least four months could save the National Health Service more than £40 million every year, suggests research published online in Archives of Disease in Childhood.
Unicef UK

Contact: Emma Dickinson
edickinson@bmj.com
44-020-738-36529
BMJ-British Medical Journal

Public Release: 4-Dec-2014
Heart
Cons of regular low-dose aspirin to stave off serious illness in women outweigh pros
The pros of giving healthy women regular low-dose aspirin to stave off serious illness, such as cancer and heart disease, are outweighed by the cons, suggests a large study published online in the journal Heart.
NIH/National Heart, Lung, and Blood Institute, NIH/National Cancer Institute

Contact: Emma Dickinson
edickinson@bmj.com
44-020-738-36529
BMJ-British Medical Journal

Public Release: 3-Dec-2014
Nature
'Wound response' of cancer stem cells may explain chemo-resistance in bladder cancer
A novel mechanism -- similar to how normal tissue stem cells respond to wounding -- might explain why bladder cancer stem cells actively contribute to chemo-resistance after multiple cycles of chemotherapy drug treatment. Targeting this 'wound response' of cancer stem cells can potentially provide a novel approach for therapeutic invention, said researchers from the National Cancer Institute-designated Dan L. Duncan Cancer Center at Baylor College of Medicine.

Contact: Glenna Picton
picton@bcm.edu
713-798-4710
Baylor College of Medicine

Public Release: 3-Dec-2014
Nature Communications
Not all induced pluripotent stem cells are made equal: McMaster researchers
Human stem cells made from adult donor cells 'remember' where they came from and that's what they prefer to become again. This means the type of cell obtained from an individual patient to make pluripotent stem cells, determines what can be best done with them.
Canadian Institutes of Health Research, Canadian Cancer Society Research Institute

Contact: Veronica McGuire
vmcguir@mcmaster.ca
90-552-591-402-2169
McMaster University

Public Release: 3-Dec-2014
Proceedings of the National Academy of Sciences
UNC researchers pinpoint chemo effect on brain cells, potential link to autism
University of North Carolina School of Medicine researchers have found for the first time a biochemical mechanism that could be a cause of chemo brain' -- the neurological side effects such as memory loss, confusion, difficulty thinking, and trouble concentrating that many cancer patients experience while on chemotherapy to treat tumors in other parts of the body.
National Institutes of Health, Simons Foundation, Angelman Syndrome Foundation

Contact: Mark Derewicz
mark.derewicz@unchealth.unc.edu
919-923-0959
University of North Carolina Health Care

Public Release: 3-Dec-2014
Journal of Translational Medicine
Cancer from asbestos caused by more than one cell mutation
It has been a long held belief that tumors arising from exposure to asbestos are caused by mutations in one cell, which then produces multiple clones. This hypothesis is challenged by new research published in the open-access Journal of Translational Medicine, which suggests it is caused by mutations in multiple cells.

Contact: Shane Canning
shane.canning@biomedcentral.com
44-203-192-2243
BioMed Central

Public Release: 3-Dec-2014
Molecular Biology of the Cell
Virginia Tech researchers connect sleep cycle, cancer incidence
Researchers reveal that a protein responsible for regulating the body's sleep cycle, or circadian rhythm, also protects the body from developing sporadic forms of cancers.

Contact: Lindsay Taylor Key
ltkey@vt.edu
540-231-6594
Virginia Tech

Public Release: 3-Dec-2014
European Urology
Common prostate cancer treatment associated with decreased survival in older men
A common prostate cancer therapy should not be used in men whose cancer has not spread beyond the prostate, according to a new study led by researchers at Henry Ford Hospital. The findings are particularly important for men with longer life expectancies because the therapy exposes them to more adverse side effects, and it is associated with increased risk of death and deprives men of the opportunity for a cure by other methods.
Vattikuti Urology Institute

Contact: Dwight Angell
dwight.angell@hfhs.org
313-876-8709
Henry Ford Health System

Public Release: 3-Dec-2014
Advances in Experimental Medicine and Biology
Study: How red wine prevents cancer
'Alcohol damages cells and resveratrol kills damaged cells,' says Robert Sclafani, Ph.D., investigator at the University of Colorado Cancer Center.

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

Public Release: 2-Dec-2014
JAMA
Study examines use of drugs to strengthen bones for men receiving ADT
Although some guidelines recommend use of bisphosphonates, a class of drugs used to strengthen bone, for men on androgen deprivation therapy, an analysis finds that prescriptions for these drugs remains low, even for those men at high risk of subsequent fractures, according to a study in the Dec. 3 issue of JAMA.

Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
The JAMA Network Journals

Public Release: 2-Dec-2014
PLOS Medicine
Lung cancer risk model refines decisions to screen
A new method for determining lung cancer risk could more efficiently identify individuals for annual screening and catch more cancers early, according to a study published in this week's PLOS Medicine. The study, conducted by Martin Tammemägi of Brock University, Canada, and colleagues, evaluates a lung cancer risk prediction model and identifies a risk threshold for selecting individuals for annual lung cancer screening.

Contact: Maya Sandler
medicinepress@plos.org
PLOS

Public Release: 2-Dec-2014
RSNA 2014 100th Scientific Assembly and Annual Meeting
3-D mammography improves cancer detection in dense breasts
A major new study has found that digital breast tomosynthesis, also known as 3-D mammography, has the potential to significantly increase the cancer detection rate in mammography screening of women with dense breasts.

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America

Public Release: 2-Dec-2014
RSNA 2014 100th Scientific Assembly and Annual Meeting
Risk-based screening misses breast cancers in women in their forties
A study of breast cancers detected with screening mammography found that strong family history and dense breast tissue were commonly absent in women between the ages of 40 and 49 diagnosed with breast cancer.

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America

Public Release: 2-Dec-2014
Journal of Clinical Oncology
New cause of child brain tumor condition identified
Doctors and scientists from the University of Manchester have identified changes in a gene, which can increase the risk of developing brain tumors in children with a rare inherited condition called Gorlin syndrome.
British Skin Foundation

Contact: Jamie Brown
Jamie.brown@manchester.ac.uk
44-161-275-8383
University of Manchester

Public Release: 2-Dec-2014
PLOS ONE
People putting their lives at risk by dismissing cancer symptoms
People could be putting their lives at risk by dismissing potential warning signs of cancer as less serious symptoms, according to a Cancer Research UK-funded study published in PLOS ONE.

Contact: Greg Jones
greg.jones@cancer.org.uk
44-020-346-98311
Cancer Research UK

Public Release: 2-Dec-2014
2014 Society of Urologic Oncology Annual Meeting
Study shows Prolaris could save healthcare system $6 billion over 10 years
Clinical data from three studies with Prolaris in prostate cancer patients will be highlighted at the 2014 Society of Urologic Oncology Annual Meeting tomorrow. The new data show that the Prolaris test could save the healthcare system $6 billion over 10 years and that physicians are using the test appropriately to personalize treatment options for their patients.

Contact: Ronald Rogers
rrogers@myriad.com
801-584-3065
Myriad Genetics, Inc.

Public Release: 2-Dec-2014
Annals of Medicine and Surgery
Chemotherapy can complicate immediate breast reconstruction after mastectomy
Immediate breast reconstruction following mastectomy is becoming more prevalent. However, in breast cancer patients undergoing simultaneous chemotherapy, thrombotic complications can arise that can delay or significantly modify reconstructive plans. Outcomes of cases illustrating potential complications are published in the current issue of Annals of Medicine and Surgery.

Contact: Allan Ross
hmsmedia@elsevier.com
212-633-3769
Elsevier Health Sciences

Public Release: 2-Dec-2014
Cancer Prevention Research
Antacids linked to better survival in head and neck cancer
Patients with head and neck cancer who used antacid medicines to control acid reflux had better overall survival, according to a new study from the University of Michigan Comprehensive Cancer Center.
NIH/National Cancer Institute, NIH/National Institute of Dental and Craniofacial Research, American Cancer Society, University of Michigan

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 1-Dec-2014
American Journal of Pathology
Prognostic role found for miR-21 expression in triple-negative breast cancer
'Triple-negative' breast cancer occurs in patients whose cells do not express receptors for estrogen, progesterone, and/or human epidermal growth factor receptor 2 (ER/PR/HER2). Because of the absence of these predictive biomarkers, treatment assignment can be difficult. Now, researchers report that high levels of the microRNA miR-21 in the tumor microenvironment, but not in the tumor epithelia, are associated with worse clinical outcomes for patients with triple-negative breast cancer, thus identifying a possible triple-negative breast cancer prognostic biomarker.
NIH/National Cancer Institute, NIH/National Center for Research Resources, Van Andel Research Institute, Hitchcock Foundation, Van Andel Institute Purple Community

Contact: Eileen Leahy
ajpmedia@elsevier.com
732-238-3628
Elsevier Health Sciences

Public Release: 1-Dec-2014
Genes & Development
Protein kinase R and dsRNAs, new regulators of mammalian cell division
The research team of the Center for RNA Research at IBS has succeeded in revealing that the dsRNAs and Protein Kinase R regulate division of mammalian cells.
Institute for Basic Science

Contact: Hanbin Oh
ohanvin@ibs.re.kr
82-428-788-182
Institute for Basic Science

Public Release: 1-Dec-2014
Oncogene
Stressed-out cancers may provide drug target
Research at the University of Adelaide has discovered cancer cells may be particularly susceptible to metabolic stress -- opening the way for new targeted therapy that won't harm normal cells.
National Health and Medical Research Council

Contact: Stephen Gregory
stephen.gregory@adelaide.edu.au
61-466-987-583
University of Adelaide

Showing releases 151-175 out of 1246.

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