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Showing releases 151-175 out of 1330.

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Public Release: 5-Aug-2015
PLOS Genetics
Penn study details powerful molecular promoter of colon cancers
Cancer researchers already know of some oncogenes and other factors that promote the development of colon cancers, but they don't yet have the full picture of how these cancers originate and spread. Now researchers have illuminated another powerful factor in this process, by unraveling an additional pathway for the origin of colon cancer.
National Institutes of Health, The Lustgarten Family, The Hansen Foundation, and National Colon Cancer Research Alliance

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 5-Aug-2015
Cancer Discovery
Penn scientists identify key genetic factor that keeps moles from turning into melanoma
Moles are benign tumors found on the skin of almost every adult. Scientists have known for years that a mutation in the BRAF gene makes them start growing, but until now haven't understood why they stop. Now, researchers from the Perelman School of Medicine at the University of Pennsylvania have identified a major genetic factor that keeps moles in their usual non-cancerous, no-growth state.
National Institutes of Health, Melanoma Research Alliance, Dermatology Foundation, American Skin Association, Melanoma Research Foundation

Contact: Katie Delach
University of Pennsylvania School of Medicine

Public Release: 5-Aug-2015
Scientists solve structure of important protein for tumor growth
In a collaborative study between at Sanford Burnham Prebys Medical Discovery Institute and the Argonne National Laboratory, scientists have used a highly specialized X-ray crystallography technique to solve the protein structure of hypoxia-inducible factors, important regulators of a tumor's response to low oxygen.
National Institutes of Health

Contact: Patrick Bartosch
Sanford-Burnham Prebys Medical Discover Institute

Public Release: 5-Aug-2015
The Annals of Thoracic Surgery
Delay in treatment, missed diagnostic testing found among lung cancer patients
Patients undergoing surgery for lung cancer may wait too long to receive treatment, and too many patients skip vital diagnostic steps that are needed to help determine the best possible treatment, according to study published in the August 2015 issue of The Annals of Thoracic Surgery.

Contact: Cassie McNulty

Public Release: 5-Aug-2015
Proceedings of the National Academy of Sciences
Cancer treatment models get real
Rice University and MD Anderson Cancer Center researchers use a custom flow perfusion bioreactor to show the value of testing cancer samples in realistic environments.
MD Anderson Cancer Center, National Institutes of Health

Contact: David Ruth
Rice University

Public Release: 5-Aug-2015
Scientists discover cancer markers may be present early during human development
Researchers at the Virginia Bioinformatics Institute have uncovered a link between the genomes of cells originating in the neural crest and development of tumors -- a discovery that could lead to new ways to diagnose and treat cancer.

Contact: John Pastor
Virginia Tech

Public Release: 4-Aug-2015
Journal of Clinical Investigation
Key protein drives 'power plants' that fuel cells in heart and other key body systems
Case Western Reserve University scientists have discovered that a protein called Kruppel-like Factor 4 (KLF4) controls mitochondria -- the 'power plants' in cells that catalyze energy production. Specifically, they determined KLF4's pivotal role through its absence -- that is, the mitochondria malfunction without enough of the protein, which in turn leads to reduced energy. The researchers' findings appear in the August edition of The Journal of Clinical Investigation.
National Institutes of Health, American Heart Association

Contact: Jeannette Spalding
Case Western Reserve University

Public Release: 4-Aug-2015
British Journal of Cancer
England still struggling to close the gap in cancer survival
Cancer survival in England remains lower than countries with similar healthcare systems, according to a new Cancer Research UK funded study published in the British Journal of Cancer today.
Cancer Research UK

Contact: Stephanie McClellan
Cancer Research UK

Public Release: 4-Aug-2015
Cancer Epidemiology, Biomarkers & Prevention
Exercise during teen years linked to lowered risk of cancer death later
Women who exercised during their teen years were less likely to die from cancer and all other causes during middle-age and later in life, according to a new study by investigators at Vanderbilt University Medical Center and the Shanghai Cancer Institute in China.
National Institutes of Health

Contact: Craig Boerner
Vanderbilt University Medical Center

Public Release: 4-Aug-2015
Nature Communications
Molecular tinkering doubles cancer drug's efficacy
Researchers at Duke University have molecularly repackaged a widely used cancer drug called paclitaxel, more than doubling its effectiveness at destroying tumors than the current gold-standard pharmaceutical, Abraxane.
National Institutes of Health

Contact: Ken Kingery
Duke University

Public Release: 3-Aug-2015
Nature Cell Biology
MD Anderson study reveals new insight into DNA repair
DNA double-strand breaks are the worst possible form of genetic malfunction that can cause cancer and resistance to therapy.

Contact: Ron Gilmore
University of Texas M. D. Anderson Cancer Center

Public Release: 3-Aug-2015
Nature Medicine
Potential new therapy approaches to reverse kidney damage identified
Adults who are worried or terrified sometimes curl up into a fetal position. Likewise, adult cells that are injured, including genetic injury leading to cancer, initiate a process that was present during embryonic development.

Contact: Ron Gilmore
University of Texas M. D. Anderson Cancer Center

Public Release: 3-Aug-2015
Plastic and Reconstructive Surgery
FAU student and surgeon collaborate on new, alternative procedure to radical mastectomy
Elizabeth Hopkins has spent more than 640 hours shadowing Hilton Becker, M.D., a plastic and reconstructive surgeon. In 2014, she had a double mastectomy as a preventive measure, using a revolutionary procedure that is an alternative to radical mastectomy. This new procedure developed by Becker is done minimally invasively and spares the skin, nipple and areola.

Contact: Gisele Galoustian
Florida Atlantic University

Public Release: 3-Aug-2015
Molecular Cell
Tel Aviv University researcher discovers trigger of deadly melanoma
Tel Aviv University researcher Dr. Carmit Levy has discovered the trigger that causes melanoma cancer cells to turn lethal.

Contact: George Hunka
American Friends of Tel Aviv University

Public Release: 3-Aug-2015
Nature Genetics
Further evidence of genetic key to deadliest form of skin cancer
Scientists from the University of Leeds have uncovered further evidence that the protective buffers at the ends of chromosomes -- known as telomeres -- are fundamental to the understanding of the deadliest form of skin cancer, melanoma.
Cancer Research UK, National Institutes of Health

Contact: Ben Jones
University of Leeds

Public Release: 3-Aug-2015
Nature Communications
Combination therapy may be more effective against the most common ovarian cancer
High-grade serous ovarian cancer often responds well to the chemotherapy drug carboplatin, but why it so frequently comes back after treatment has been a medical mystery.
American Cancer Society, NIH/National Cancer Institute, NIH/National Center for Advancing Translational Science UCLA Clinical Translational Science Institute

Contact: Kim Irwin
University of California - Los Angeles Health Sciences

Public Release: 3-Aug-2015
Clinical Cancer Research
Urine test for early stage pancreatic cancer possible after biomarker discovery
A combination of three proteins found at high levels in urine can accurately detect early-stage pancreatic cancer, UK researchers have found. The discovery could lead to a non-invasive, inexpensive test to screen people at high risk of developing the disease.
Pancreatic Cancer Research Fund

Contact: Becky Tanner
Pancreatic Cancer Research Fund

Public Release: 3-Aug-2015
American Journal of Epidemiology
Yo-yo dieting not associated with increased cancer risk
The first comprehensive study of its kind finds weight cycling, repeated cycles of intentional weight loss followed by regain, was not associated with overall risk of cancer in men or women.
American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 3-Aug-2015
Journal of Investigative Dermatology
Veterans returning from Middle East face higher skin cancer risk
Soldiers who served in the glaring desert sunlight of Iraq and Afghanistan returned home with an increased risk of skin cancer, due not only to the desert climate, but also a lack of sun protection, Vanderbilt dermatologist Jennifer Powers, M.D., reports in a study published recently in the Journal of Investigative Dermatology.
Skin Cancer Foundation, NIH/National Center for Advancing Translational Science

Contact: Craig Boerner
Vanderbilt University Medical Center

Public Release: 3-Aug-2015
Scaffold-integrated microchips for end-to-end in vitro tumor cell attachment and xenograft formation
A team of researchers from Massachusetts General Hospital, Florida State University, and University of Massachusetts has developed a new microchip that can retrieve microfluidically attached cancer cells for serial analysis by integrating a 3-D hydrogel scaffold into a fluidic device. The researchers describe their approach in the forthcoming issue of the journal TECHNOLOGY.
National Institute of Health, and Shriners Hospitals for Children

Contact: Philly Lim
World Scientific

Public Release: 3-Aug-2015
Future Science OA
Are animal models still essential to biological research?
Future Science Group today announced the publication of a new article in Future Science OA, covering the use of animal models in scientific research.

Contact: Leela Ripton
Future Science Group

Public Release: 3-Aug-2015
Nature Communications
Stress responder is a first responder in helping repair DNA damage and avoiding cancer
DNA damage increases the risk of cancer, and researchers have found that a protein, known to rally when cells get stressed, plays a critical, early step in its repair.
National Institutes of Health

Contact: Toni Baker
Medical College of Georgia at Georgia Regents University

Public Release: 3-Aug-2015
New England Journal of Medicine
Irradiation of regional nodes in stage I - III breast cancer patients affects overall survival
At a median follow-up of 10.9 years, an EORTC study has shown that irradiation of regional nodes in patients with stage I, II, or III breast cancer has a marginal effect on overall survival, the primary endpoint (at 10 years, overall survival was 82.3 percent for regional irradiation versus 80.7 percent for no regional irradiation).

Contact: John Bean
European Organisation for Research and Treatment of Cancer

Public Release: 3-Aug-2015
Chemical Science
Molecular spies to fight cancer
Scientists at Helmholtz-Zentrum Dresden-Rossendorf, together with colleagues at the University of Zurich and the Ruhr-Universität Bochum, have for the first time successfully tested a new tumor diagnosis method under near-real conditions. The procedure first sends out an antibody as a 'spy' to detect the diseased cells and binds to them. This antibody in turn attracts a subsequently administered radioactively labeled probe. The scientists could then clearly visualize the tumor by utilizing a tomographic method.

Contact: Simon Schmitt
Helmholtz-Zentrum Dresden-Rossendorf

Public Release: 1-Aug-2015
Cancer Research
Childhood cancer cells drain immune system's batteries
Cancer cells in neuroblastoma contain a molecule that breaks down a key energy source for the body's immune cells, leaving them too physically drained to fight the disease, according to new research published in the journal Cancer Research today.
Cancer Research UK

Contact: Greg Jones
Cancer Research UK

Showing releases 151-175 out of 1330.

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