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Showing releases 151-175 out of 1352.

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Public Release: 11-May-2016
Neurology
MS drug mitoxantrone may be linked to increased risk of colorectal cancer
The multiple sclerosis (MS) drug mitoxantrone may be associated with an increased risk of colorectal cancer, according to a study published in the May 11, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology. Mitoxantrone suppresses the immune system. It was first developed as a chemotherapy drug for certain cancers.

Contact: Rachel Seroka
rseroka@aan.com
612-928-6129
American Academy of Neurology

Public Release: 10-May-2016
Nature Communications
New research gives deeper understanding of why some breast cancers are hard to treat
Scientists have unearthed crucial new genetic information about how breast cancer develops and the genetic changes which can be linked to survival.

Contact: Fiona Dennehy
fiona.dennehy@cancer.org.uk
Cancer Research UK

Public Release: 10-May-2016
JAMA
Breast cancer screening accuracy and time spent evaluating mammograms
Longer time spent by film readers interpreting screening mammograms did not result in a reduced rate of breast cancer detection, according to a study appearing in the May 10, 2016 issue of JAMA.

Contact: Sian Taylor-Phillips, Ph.D.
s.taylor-phillips@warwick.ac.uk
The JAMA Network Journals

Public Release: 10-May-2016
PLOS ONE
Gamma-retroviruses preferentially integrate near cancer-associated genes
Identifying the sites where gamma-retroviruses commonly insert into the genome may help to identify genes associated with specific cancer types, according to a study published April 20, 2016 in the open-access journal PLOS ONE by Kathryn Gilroy at the University of Glasgow, UK, and colleagues.

Contact: Beth Jones
bjones@plos.org
PLOS

Public Release: 10-May-2016
JAMA
Breast cancer detection rates of mammogram readers don't decline over time
A new study has found there is no decline over time in the accuracy of medical staff who analyze mammogram scans for indications of breast cancer. Research conducted at the University of Warwick investigated whether detection rates dropped towards the end of each batch of mammogram readings.
National Institute for Health Research

Contact: Nicola Jones
N.Jones.1@warwick.ac.uk
07-920-531-221
University of Warwick

Public Release: 10-May-2016
Science Advances
Researchers discover first safe way to deliver drugs to the placenta
For the first time, researchers have devised a method to selectively deliver drugs to a pregnant woman's placenta without harming the foetus, in a development which could help prevent some premature births and treat conditions such as pre-eclampsia.
BBSRC

Contact: Jamie Brown
jamie.brown@manchester.ac.uk
44-161-275-8383
University of Manchester

Public Release: 10-May-2016
Biophysical Journal
Why cancer drugs can't take the pressure
A major reason why cancer drugs fail is that they cannot penetrate the high-pressure environment of solid tumors. A study published May 10 in Biophysical Journal reveals that hyaluronic acid is primarily responsible for generating elevated gel-fluid pressures in tumors. In a mouse model of pancreatic cancer, treatment with an enzyme that breaks down hyaluronic acid normalized fluid pressure in tumors and allowed vessels to re-expand, thereby overcoming a major barrier to drug delivery.

Contact: Joseph Caputo
jcaputo@cell.com
617-397-2802
Cell Press

Public Release: 10-May-2016
Immunity
Nuclear DNA gets cut and activates immune system to attack cancer cells
The enzyme MUS81 cuts DNA in the nucleus of cancer cells, causing the cut DNA to move to the cytoplasm instead of becoming degraded. The out-of-place DNA triggers an immune response against cancer cells. Discovering this new means of enhancing anti-cancer immune responses could lead to more effective cancer therapies using a combination of a MUS81-stimulating drug and an immunotherapy.

Contact: Khor Ing Wei
medkiw@nus.edu.sg
65-677-26983
National University of Singapore

Public Release: 10-May-2016
Cancer Biotherapy and Radiopharmaceuticals
Long-term survival achieved in metastatic melanoma with personalized vaccine
Two patients with melanoma that had spread to the liver survived for at least 8.5 and 12 years after resection of the hepatic tumor and treatment with patient-specific immunotherapeutic vaccines. The vaccines, designed to activate the immune system against the tumor, were derived from the patients' own dendritic cells loaded with proteins isolated from their tumors, as described in an article published in Cancer Biotherapy and Radiopharmaceuticals.

Contact: Kathryn Ryan
kryan@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 10-May-2016
CPT: Pharmacometrics & Systems Pharmacology
Modeling and simulation help optimize chemotherapy to combat brain tumor
St. Jude Children's Research Hospital used advanced pharmacologic modeling and simulation for the first time to translate promising laboratory results into a phase I clinical trial for pediatric brain tumor patients.
Collaborative Ependymoma Research Network, National Institutes of Health, ALSAC

Contact: Frannie Marmorstein
media@stjude.org
901-595-0221
St. Jude Children's Research Hospital

Public Release: 10-May-2016
Genome Research
Researchers demonstrate link between 'jumping gene' and colon cancer
For the first time, researchers have demonstrated conclusively that 'jumping genes' appear to play a key role in the generation of cancer. This is the first study to ever elucidate this process.

Contact: David Kohn
dkohn@som.umaryland.edu
410-706-7590
University of Maryland School of Medicine

Public Release: 10-May-2016
Journal of Laparoendoscopic & Advanced Surgical Techniques
How does robotic video-assisted thoracoscopic surgery compare to VATS for treating lung cancer?
A new study shows that robotic video-assisted lung resection to remove a tumor achieves comparable outcomes with no significant differences in complications compared to conventional video-assisted thoracoscopic surgery (VATS), and robotic VATS (RVATS) may allow for preservation of more healthy lung tissue. The study, 'Robotic Versus Thoracoscopic Resection for Lung Cancer: Early Results of a New Robotic Program' is published in Journal of Laparoendoscopic & Advanced Surgical Techniques.

Contact: Kathryn Ryan
kryan@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 10-May-2016
Cancer Cell
Loss of chromosome 8p governs tumor suppression and drug response
In a typical cancer cell, up to one-quarter of the genome is lost due to large chromosomal deletions, while the concomitant loss of hundreds of genes creates vulnerabilities that are impossible to reveal through the study of individual genes. Professor Anna Sablina and her team at VIB/KU Leuven optimized a workflow for the generation of cell lines with targeted chromosomal deletions.

Contact: Sooike Stoops
sooike.stoops@vib.be
32-924-46611
VIB (the Flanders Institute for Biotechnology)

Public Release: 10-May-2016
Proceedings of the National Academy of Sciences
Research discovers mechanism that causes cancer cells to escape from the immune system
Researchers at the Texas A&M Health Science Center found that when cancer cells are able to block the function of a gene called NLRC5, they are able to evade the immune system and form tumors, according to research in the Proceedings of the National Academy of Sciences. The discovery indicates NLRC5 as a novel biomarker for cancer patient survival and therapeutic response, as well as a potential target for new treatments.
National Institutes of Health, Broad Foundation, National Multiple Sclerosis Society, Texas A&M Clinical Science and Translational Research Institute, Texas A&M Genomics Grant Program, Center for Translational Environmental and Health Research

Contact: Holly Shive
hshive@tamhsc.edu
979-436-0613
Texas A&M University

Public Release: 10-May-2016
PLOS ONE
Potential target in treatment of oral cancer discovered
For the first time, researchers have identified a reliable marker (PDGFRβ) to detect carcinoma-associated fibroblasts (cells within the tumor that encourage growth and metastasis) (CAFs) in oral cancer tissues. With this discovery, anti-PDGFRβ treatment could soon be combined with existing tumor treatments to provide a more effective cancer therapy.
National Institutes of Health, Evans Center for Interdisciplinary Biomedical Research

Contact: Gina DiGravio
ginad@bu.edu
617-638-8480
Boston University Medical Center

Public Release: 9-May-2016
European Urology
Radiotherapy halves deaths from prostate cancer 15 years after diagnosis
A longitudinal Nordic study, comparing the results of hormone (antiandrogen) therapy with or without the addition of local radiotherapy, shows that a combination of treatments halves the risk of death from prostate cancer 15 years after diagnosis. This according to a follow-up study recently published in the journal European Urology.

Contact: Daniel Harju
daniel.harju@umu.se
46-725-522-918
Umea University

Public Release: 9-May-2016
eLife
Do genes express themselves through poetry?
A new study from Michigan State University makes inroads in learning to 'read' the genome, a key goal of modern biology.
National Institutes of Health

Contact: Layne Cameron
layne.cameron@cabs.msu.edu
517-353-8819
Michigan State University

Public Release: 9-May-2016
BMJ Open
Radiotherapy during surgery could save millions of travel miles and tons of CO2
One targeted dose of radiotherapy given during surgery to remove early stage breast cancer could save millions of travel miles, enough CO2 emissions for a 100 hectare forest, and free up thousands of hours of women's time, concludes research published in the online journal BMJ Open.

Contact: Caroline White
cwhite@bmj.com
44-798-080-0465
BMJ

Public Release: 9-May-2016
Cancer Cell
Can gender play a role in determining cancer treatment choices?
It is well known that men and women differ in terms of cancer susceptibility, survival and mortality, but exactly why this occurs at a molecular level has been poorly understood.

Contact: Ron Gilmore
rlgilmore1@mdanderson.org
713-745-1898
University of Texas M. D. Anderson Cancer Center

Public Release: 9-May-2016
Nature Genetics
Discovery of lung cancer mutations responsive to targeted therapies and to immunotherapies
Researchers from several major US universities and ITMO University in Russia have identified a number of new driver mutations in lung cancer cells that may be responsive to genomically targeted therapies and to immunotherapy.
NIH/National Cancer Institute, US Department of Defense, American Cancer Society Research

Contact: Dmitry Malkov
dvmalkov@corp.ifmo.ru
7-953-377-5508
ITMO University

Public Release: 9-May-2016
Human Gene Therapy
Junction opening protein boosts cancer-killing effect of oncolytic virus
A new study shows that the anti-tumor effect of oncolytic virus therapy is significantly greater in mice when the virus is genetically modified to express a junction opening (JO) protein, which helps the cancer-killing agent better penetrate solid tumors. The potential for JO to improve cancer therapy with various types of oncolytic viruses is described in Human Gene Therapy.

Contact: Kathryn Ryan
kryan@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 9-May-2016
Cancer Cell
TGen and international team find new avenues of precision medicine for treating cancer
An international team of scientists, including those at the Translational Genomic Research Institute, have discovered new avenues of potential treatments for a rare and deadly cancer known as adrenocortical carcinoma (ACC). In a study published today in the scientific journal Cancer Cell, researchers conducted an extensive genomic profile of ACC, a cancer of the adrenal glands, located above the kidneys. Current treatment options for ACC have not changed in decades and are not curative.
National Institutes of Health

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute

Public Release: 9-May-2016
Journal of Nuclear Medicine
A better way to diagnose and manage neuroendocrine tumors
A recent study reported in the May issue of the Journal of Nuclear Medicine demonstrates that Ga-68 DOTATATE PET/CT scans are superior to In-111 pentetreotide scans, the current imaging standard in the United States for detecting neuroendocrine tumors, and could significantly impact treatment management.
US Department of Veterans Affairs, Society of Nuclear Medicine and Molecular Imaging Clinical Trials Network, Vanderbilt Institute for Clinical and Translational Research

Contact: Laurie Callahan
lcallahan@snmmi.org
Society of Nuclear Medicine

Public Release: 9-May-2016
Nicotine and Tobacco Research
E-cigarettes not meeting potential as 'disruptive technology,' Georgia State public health study shows
Most smokers who have tried electronic cigarettes have rejected them as less satisfying than regular cigarettes, reducing their potential to be a 'disruptive technology' that could help a significant number of smokers to quit, according to a recent study by a team of researchers at the Tobacco Center of Regulatory Science at Georgia State University.

Contact: Anna Varela
avarela@gsu.edu
404-413-1504
Georgia State University

Public Release: 9-May-2016
Cancer Cell
Study shows possible 'key' to improved therapy for adrenocortical carcinoma
A study comprised of 39 international institutions revealed significant new findings about adrenocortical carcinoma, a rare cancer with an often poor prognosis.

Contact: Ron Gilmore
rlgilmore1@mdanderson.org
713-745-1898
University of Texas M. D. Anderson Cancer Center

Showing releases 151-175 out of 1352.

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