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Showing releases 151-175 out of 1271.

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Public Release: 9-Feb-2015
Cancer Cell
'Jekyll and Hyde'protein both prevents and spreads cancer
Scottish author Robert Louis Stevenson tapped into primal fears when he penned 'Dr. Jekyll and Mr. Hyde,' a 19th century novel about a sinister physician, raising the question, 'Can evil and good exist in the same person?'

Contact: Ron Gilmore
rlgilmore1@mdanderson.org
713-745-1898
University of Texas M. D. Anderson Cancer Center

Public Release: 9-Feb-2015
Cancer
Study identifies 8 signs associated with impending death in cancer patients
Researchers at The University of Texas MD Anderson Cancer Center have identified eight highly specific physical and cognitive signs associated with imminent death in cancer patients. The findings, published in the journal Cancer, could offer clinicians the ability to better communicate with patients and families. They may also guide both the medical team and caregivers on complex decision making, such as discontinuation of tests and therapy, plans for hospital discharge and hospice referral.

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center

Public Release: 9-Feb-2015
Clinical Cancer Research
Could there be a gleevec for brain cancer?
The drug Gleevec (imatinib mesylate) is well known not only for its effectiveness against chronic myeloid leukemia (CML) and acute lymphoblastic leukemia, but also for the story behinds its development. The drug was specifically designed to target an abnormal molecule--a fusion of two normal cell proteins--that fueled a tumor's growth.
NIH/National Institute of Neurological Disorders and Stroke

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center

Public Release: 9-Feb-2015
Nature Communications
What autism can teach us about brain cancer
Applying lessons learned from autism to brain cancer, researchers at The Johns Hopkins University have discovered why elevated levels of the protein NHE9 add to the lethality of the most common and aggressive form of brain cancer, glioblastoma. Their discovery suggests that drugs designed to target NHE9 could help to successfully fight the deadly disease.
NIH/National Institute of Neurological Disorders and Stroke, NIH/National Institute of Diabetes and Digestive and Kidney Diseases, American Heart Association, Johns Hopkins Post-Baccalaureate Research Education Program

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine

Public Release: 9-Feb-2015
Nature Genetics
UCSF-led study shows why some targeted cancer drugs lose effectiveness
A protein called YAP, which drives the growth of organs during development and regulates their size in adulthood, plays a key role in the emergence of resistance to targeted cancer therapies, according to a new study led by UC San Francisco researchers.
NIH Director's New Innovator Award, Howard Hughes Medical Institute, Doris Duke Charitable Foundation, American Lung Association, National Lung Cancer Partnership, Sidney Kimmel Foundation for Cancer Research, Searle Scholars Program

Contact: Pete Farley
peter.farley@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 9-Feb-2015
JAMA Internal Medicine
HPV vaccination not linked to riskier sex
Receiving the HPV vaccine does not increase rates of sexually transmitted infections in adolescent females, suggesting that vaccinating girls is not likely to promote unsafe sexual activity.
National Institutes of Health, NIH/National Institute on Aging

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School

Public Release: 9-Feb-2015
Annals of Internal Medicine
News from Annals of Internal Medicine Feb. 10, 2015
Using Lung Imaging Reporting and Data System (Lung-RADS) criteria developed by the American College of Radiology to interpret low-dose CT lung screening results may reduce false positives compared to the National Lung Screening Trial, but the trade-off is reduced sensitivity, according to an article published in Annals of Internal Medicine.

Contact: Megan Hanks
mhanks@acponline.org
215-351-2656
American College of Physicians

Public Release: 9-Feb-2015
Nature Biotechnology
Computer model of blood development could speed up search for new leukaemia drugs
The first comprehensive computer model to simulate the development of blood cells could help in the development of new treatments for leukaemia and lymphoma, say researchers at the University of Cambridge and Microsoft Research.
Medical Research Council, Biotechnology and Biological Sciences Research Council, Leukaemia and Lymphoma Research, Leukemia and Lymphoma Society, Microsoft Research, Wellcome Trust

Contact: Craig Brierley
craig.brierley@admin.cam.ac.uk
44-012-237-66205
University of Cambridge

Public Release: 9-Feb-2015
Cancer
Study identifies clinical signs suggestive of impending death in patients with advanced cancer
While the diagnosis of an impending death is always sad, it can be important for patients, families, and clinicians as they make decisions related to hospital discharge, hospice referral, and treatments.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
Wiley

Public Release: 9-Feb-2015
Nature
A new opportunity to treat drug-resistant leukemia discovered
An international joint effort between University of Helsinki and Pfizer researchers has led to the discovery of a new opportunity to treat drug-resistant leukemia with an approved renal cancer drug.

Contact: Krister Wennerberg
krister.wennerberg@fimm.fi
358-504-154-900
University of Helsinki

Public Release: 9-Feb-2015
Southern Surgical Association 126th Annual Meeting
Journal of the American College of Surgeons
Many mastectomy patients with locally advanced breast cancer do not get postop radiation
Breast cancer patients who undergo a mastectomy should receive subsequent radiation treatment if their cancer has spread to four or more nearby lymph nodes, however, according to a new study, only 65 percent of these women are getting the recommended postmastectomy radiation therapy.
Louisiana State University Charles Knight Sr. Endowed Professorship

Contact: Sally Garneski
pressinquiry@facs.org
312-202-5409
American College of Surgeons

Public Release: 9-Feb-2015
Cancer Epidemiology, Biomarkers, and Prevention
Study links new genetic anomalies to breast cancer in African-American families
Researcher Heather Ochs-Balcom says, 'Our family-based gene hunt is similar to the groundbreaking study among women with European ancestry done in the early 1990s that led to the discovery of BRCA1 and BRCA2 gene mutations, which greatly increase susceptibility to breast and ovarian cancer.'

Contact: Patricia Donovan
pdonovan@buffalo.edu
716-645-4602
University at Buffalo

Public Release: 9-Feb-2015
ASTRO applauds CMS's decision to cover annual, LDCT screening for high-risk lung cancer patients
The American Society for Radiation Oncology commends the Febr. 5, 2015, decision by the Centers for Medicare and Medicaid Services to provide coverage for annual lung cancer screening via low-dose CT screening for those at highest-risk for lung cancer.

Contact: Michelle Kirkwood
michellek@astro.org
703-286-1600
American Society for Radiation Oncology

Public Release: 9-Feb-2015
Journal of National Cancer Institute
Study finds no reason for cancer survivors to be excluded in advanced stage lung cancer trials
The common practice of excluding patients with a prior cancer diagnosis from lung cancer clinical trials may not be justified, according to a study by researchers from UT Southwestern Medical Center.

Contact: Lori Sundeen Soderbergh
lori.soderbergh@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 9-Feb-2015
Nature Genetics
Inherited gene variations tied to treatment-related hearing loss in cancer patients
St. Jude Children's Research Hospital investigators have discovered inherited genetic variations that are associated with rapid hearing loss in young cancer patients treated with the drug cisplatin. The research appears in the current online issue of the scientific journal Nature Genetics.
National Institutes of Health, ALSAC

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Public Release: 9-Feb-2015
Annals of Internal Medicine
Lung screening guidelines improve on study findings
A set of guidelines developed to help standardized lung cancer screening would have generated considerably fewer false-positives than the National Lung Screening Trial produced, according to a new retrospective study.
National Institutes of Health

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 9-Feb-2015
Nature Genetics
Keck Medicine of USC researchers trace origins of colorectal cancer tumor cells
For the first time, Keck Medicine of the University of Southern California cancer researchers have traced the origins of colorectal cancer cells, finding important clues to why tumor cells become 'good' or 'bad,' with the potential of stopping them before they start.
National Cancer Institute, The V Foundation for Cancer Research

Contact: Leslie Ridgeway
lridgewa@usc.edu
323-442-2823
University of Southern California - Health Sciences

Public Release: 9-Feb-2015
Journal of Experimental Medicine
How tumor-causing cells are recruited in cancers linked to chronic inflammation
Chronic inflammation is directly associated with several types of cancer, yet the reasons as to why this happens at a cellular level remain unclear. Now, an international team of scientists led by researchers at The Wistar Institute has identified a multistep process showing not only how these cancers develop but also potentially discovering new therapeutic targets that could halt the formation and progression of tumor cells.
National Institutes of Health

Contact: Ben Leach
bleach@wistar.org
215-495-6800
The Wistar Institute

Public Release: 9-Feb-2015
Journal of Clinical Investigation
Cancer's ability to 'hijack' regulatory mechanism increases metastasis
When skyscrapers go up, contractors rely on an infrastructure of steel beams and braces. Some cancers grow the same way, using a biological matrix from which the tumor can thrive and spread.

Contact: Ron Gilmore
rlgilmore1@mdanderson.org
713-745-1898
University of Texas M. D. Anderson Cancer Center

Public Release: 9-Feb-2015
Cancer Epidemiology, Biomarkers & Prevention
Previously unknown genomic regions found in African American families with breast cancer
Study led by University at Buffalo has uncovered previously unknown segments of DNA shared by African American family members who have breast cancer. The discovery of these regions supports our hypothesis that there are still undiscovered breast cancer genes that may be unique to African and spurs researchers to focus on these specific chromosomes to learn if they house genetic mutations linked to breast cancer
Susan Komen for the Cure Foundation

Contact: Pat Donovan
pdonovan@buffalo.edu
716-645-4602
University at Buffalo

Public Release: 6-Feb-2015
Technology
New method for minimally invasive tissue ablation surgery
The armamentarium of minimally invasive surgery is enriched with a new tissue ablation technique that employs the finding that reversible electroporation electric pulses, a mainstay tool of 21st century biotechnology, can substantially augment the effectiveness of electrolytic tissue ablation, a minimally invasive tissue ablation technique that has been used infrequently since its discovery at the beginning of the 19th century.

Contact: Philly Lim
mllim@wspc.com.sg
65-646-65775
World Scientific

Public Release: 6-Feb-2015
Journal of Clinical Investigation
We're all going to die; DNA strands on the end of our chromosomes hint when
BYU professor Jonathan Alder is currently studying the gene mutations that cause people to have unnaturally short telomeres. Recent research he coauthored with collaborators at Johns Hopkins University, published in the Journal of Clinical Investigation and Chest, finds those mutations are connected to both pulmonary fibrosis and emphysema.
National Institutes of Health

Contact: Todd Hollingshead
toddh@byu.edu
801-422-8373
Brigham Young University

Public Release: 5-Feb-2015
Science of the Total Environment
Reports from Columbia's Superfund program show many US wells tainted with arsenic
Arsenic is the biggest public-health problem for water in the United States -- yet we pay far less attention to it than we do to lesser problems. The Superfund Research Program, directed by Mailman School of Public Health professor Joseph Graziano, Ph.D., says private wells present continuing risks. Even low doses of arsenic may reduce IQ in children. There are also well-documented risks of cancer, heart disease, and reduced lung function.
National Institutes of Health

Contact: Stephanie Berger
sb2247@columbia.edu
212-305-4372
Columbia University's Mailman School of Public Health

Public Release: 5-Feb-2015
Journal of Neuropathology & Experimental Neurology
Cell signaling pathway goes awry in common pediatric brain tumor
A new study by Johns Hopkins researchers links a well-known cell communication pathway called Notch to one of the most common -- but overall still rare -- brain tumors found in children.
Knights Templar Eye Foundation, Childhood Brain Tumor Foundation, National Institutes of Health, Lauren's First and Goal, Pilocytic/Pilomyxoid Research Fund

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 5-Feb-2015
Cell Reports
New study sheds light on cancer stem cell regulation
Researchers identify signaling molecules in intestinal stem cells that can lead to tumors if left unregulated. The findings suggest a new approach to targeting intestinal cancers.
National Institutes of Health, Department of Defense

Contact: Susan Gammon
sgammon@sanfordburnham.org
858-795-5012
Sanford-Burnham Medical Research Institute

Showing releases 151-175 out of 1271.

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