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Showing releases 176-200 out of 1253.

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Public Release: 2-Nov-2015
Proceedings of the National Academy of Sciences
Antiangiogenic breast cancer treatment may benefit only patients with well-perfused tumors
A Massachusetts General Hospital research team, in collaboration with at Dana-Farber Cancer Institute investigators, may have found a reason why the use of antiangiogenesis drugs -- which has improved outcomes for patients with several types of cancer -- fails to benefit some breast cancer patients. In their report, the investigators describe how preoperative treatment with the antiangiogenic drug bevacizumab primarily benefited patients whose tumors were highly perfused with blood vessels prior to treatment.
Genentech, AVON National Cancer Institute Progress for Patients Program, Department of Defense Breast Cancer Research Innovator Award, NIH/National Cancer Institute

Contact: Katie Marquedant
Massachusetts General Hospital

Public Release: 2-Nov-2015
Nature Structural & Molecular Biology
First complete pictures of cells' DNA-copying machinery
The first-ever images of the protein complex that unwinds, splits, and copies double-stranded DNA reveal something rather different from the standard textbook view. The electron microscope images, created by scientists at the US Department of Energy's Brookhaven National Laboratory with partners from Stony Brook University and Rockefeller University, offer new insight into how this molecular machinery functions.
National Institutes of Health

Contact: Karen McNulty Walsh
DOE/Brookhaven National Laboratory

Public Release: 2-Nov-2015
Nature Immunology
Cancer cells hijack glucose, alter immune cells
When cancer cells compete with immune cells for glucose, the cancer wins. As a result, the immune T cells are not healthy and don't have the weapons to kill the cancer.
National Institutes of Health, Chinese Ministry of Science and Technology, Wuhan Union Hospital Research Fund, varian Cancer Research Fund, Marsha Rivkin Center for Ovarian Cancer Research, Barbara and Don Leclair

Contact: Nicole Fawcett
University of Michigan Health System

Public Release: 2-Nov-2015
Nature Genetics
A newly discovered tumor suppressor gene affects melanoma survival
Restoring the function of this gene in melanoma cells caused them to stop growing and die.

Contact: Yael Edelman
Weizmann Institute of Science

Public Release: 2-Nov-2015
National Cancer Research Institute Cancer Conference 2015
Quarter of Londoners diagnosed with cancer at A&E are dead within two months
A quarter of patients diagnosed with cancer after going to London A&E departments will have died within two months, according to research presented at the National Cancer Research Institute Cancer Conference in Liverpool.

Contact: Greg Jones
Cancer Research UK

Public Release: 2-Nov-2015
Nature Chemical Biology
Griffith University reveals world-first 3-D image of a protein involved in cancer spread
Griffith University's world leading Institute for Glycomics has made scientific history by determining the first three-dimensional image of a protein linked to the spread of cancer.

Contact: Michael Jacobson
Griffith University

Public Release: 2-Nov-2015
National Cancer Research Institute Cancer Conference 2015
Different types of ovarian cancer have different causes
The more children a woman has or whether a woman has had her fallopian tubes cut lowers the risk of different types of ovarian cancer to different levels, according to new research presented at the 2015 National Cancer Research Institute Cancer Conference Tuesday.
Cancer Research UK, Medical Research Council

Contact: Paul Thorne
Cancer Research UK

Public Release: 2-Nov-2015
National Cancer Research Institute Cancer Conference
Scientists discover how to better map brain tumors
Scientists have discovered a protein that helps map the edge of brain tumors more clearly so they show up on magnetic resonance imaging scans, according to new research presented at the National Cancer Research Institute Cancer Conference in Liverpool today.
Cancer Research UK, Medical Research Council

Contact: Stephanie McClellan
Cancer Research UK

Public Release: 2-Nov-2015
Cellular and Molecular Gastroenterology and Hepatology
Studying cancer DNA in blood may help personalize treatment in liver cancer
Fragments of cancer DNA circulating in a patient's bloodstream could help doctors deliver more personalized treatment for liver cancer, researchers at Hiroshima University, Japan report.
Japanese Ministry of Health, Labor and Welfare, Japanese Ministry of Education Culture Sports Science and Technology, Government of Japan, and others

Contact: Norifumi Miyokawa
Hiroshima University

Public Release: 1-Nov-2015
Cancer Research
Skin cancer-causing fusion gene identified
Fusion genes are hybrid genes formed as a result of gene rearrangement or mutation. They can be used to develop more effective treatments for cancers that express their own particular type of fusion gene. Researchers from Kumamoto and Kisato Universities in Japan have revealed a new fusion gene related to cutaneous angiosarcoma, a malignant form of skin cancer with a very poor survival rate. Its discovery will help to improve diagnostic and therapeutic techniques.

Contact: J. Sanderson
Kumamoto University

Public Release: 1-Nov-2015
National Cancer Research Institute 2015
Cancer Cell
New treatment targets cancers with particular genetic signature
Oxford University's Dr Tim Humphrey and team found that cancer cells with a mutated SETD2 gene were killed by a drug called AZD1775 that inhibits a protein called WEE1.
Medical Research Council, Cancer Research UK, Swiss National Science Foundation

Contact: Tom Calver
University of Oxford

Public Release: 1-Nov-2015
National Cancer Research Institute Cancer Conference
Around a fifth of unvaccinated ethnic school girls think they don't need HPV jab
Around 20 per cent of girls from ethnic minority backgrounds are not being vaccinated against the Human Papilloma Virus because they feel they don't need to have it.
Cancer Research UK

Contact: Stephanie McClellan
Cancer Research UK

Public Release: 31-Oct-2015
National Cancer Research Institute Cancer Conference 2015
Heat-activated 'grenade' to target cancer
Researchers have developed cancer drug-packed 'grenades' armed with heat sensitive triggers, allowing for treatment to be targeted directly at tumours, according to two studies due to be presented at the National Cancer Research Institute (NCRI) Cancer Conference in Liverpool.
European Commission, North West Centre for Advanced Drug Delivery

Contact: Greg Jones
Cancer Research UK

Public Release: 30-Oct-2015
Nucleic Acids Research
Genetics of cancer cells: Computational models to sort out the chaos
Scientists of the Luxembourg Centre for Systems Biomedicine of the University of Luxembourg have developed a method for analysing the genome of cancer cells more precisely than ever before. The team led by Prof. Antonio del Sol, head of the research group Computational Biology, is employing bioinformatics: Using novel computing processes, the researchers have created models of the genome of cancer cells based on known changes to the genome. These models are useful for determining the structure of DNA in tumors

Contact: Sabine Mosch
University of Luxembourg

Public Release: 30-Oct-2015
Mayo Clinic Proceedings
Stool DNA test accurate in screening for colorectal cancer in Alaska Native people
Cologuard stool DNA testing for colorectal cancer was found to be an accurate noninvasive screening option for Alaska Native people, a population with one of world's highest rates of colorectal cancer, concluded researchers from the Alaska Native Tribal Health Consortium and Mayo Clinic.
Richard M. Schulze Family Foundation

Contact: Brian Kilen
Mayo Clinic

Public Release: 30-Oct-2015
New computational strategy finds brain tumor-shrinking molecules
Patients with glioblastoma, a type of malignant brain tumor, usually survive fewer than 15 months following diagnosis. Since there are no effective treatments for the deadly disease, University of California, San Diego researchers developed a new computational strategy to search for molecules that could be developed into glioblastoma drugs. In mouse models of human glioblastoma, one molecule they found shrank the average tumor size by half. The study is published October 30 by Oncotarget.
NIH/National Institutes of Health, Voices Against Brain Cancer Foundation, Christopher and Bronwen Gleeson Family Trust, American Brain Tumor Association Drug Discovery Grant

Contact: Heather Buschman
University of California - San Diego

Public Release: 30-Oct-2015
Forget counting sheep -- Therapy could help chronic pain sufferers get a good night's sleep
Research conducted at the University of Warwick indicates that chronic pain sufferers could benefit from therapy to help them sleep better.
Warwick Research Development Fund Award

Contact: Nicola Jones
University of Warwick

Public Release: 30-Oct-2015
Stem Cell Reports
A Prkci gene keeps stem cells in check
When it comes to stem cells, too much of a good thing isn't wonderful: producing too many new stem cells may lead to cancer; producing too few inhibits the repair and maintenance of the body. In a paper published in Stem Cell Reports, USC researcher In Kyoung Mah from the lab of Francesca Mariani and colleagues at the University of California, San Diego, (UCSD) describe a key gene in maintaining this critical balance between producing too many and too few stem cells.
University of Southern California, Robert E. and May R. Wright Foundation

Contact: Cristy Lytal
University of Southern California - Health Sciences

Public Release: 30-Oct-2015
Cancer Cell
Tumor RNA in platelets may diagnose and classify cancer, identify treatment strategies
Analysis of tumor RNA carried in platelets - blood components best known for their role in clotting -- may prove to be more useful than other 'liquid biopsy' technologies for diagnosing cancer and determining its primary location and potential therapeutic approaches.
European Research Council, Dutch Organisation of Scientific Research, National Cancer Institute

Contact: Katie Marquedant
Massachusetts General Hospital

Public Release: 29-Oct-2015
Molecular Cell
Virginia Tech study of basic cell processes may inform health, synthetic biology efforts
The study has implications for cancer research, as scientists try to understand how cells avoid errors that promote cancer development. It could also be useful in synthetic biology, where scientists work to make robust mechanisms for synthetic life.

Contact: Tiffany Trent
Virginia Tech

Public Release: 29-Oct-2015
Plastic and Reconstructive Surgery
No need to stop antidepressants before plastic surgery, evidence suggests
For patients undergoing plastic surgery procedures, there's no consistent evidence that taking antidepressants increases the risk of bleeding, breast cancer, or other adverse outcomes, concludes a research review in the November issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons.

Contact: Connie Hughes
Wolters Kluwer Health

Public Release: 29-Oct-2015
Breast Cancer Research and Treatment
Exercise could give margin of safety to women who want to delay preventive mastectomy
Regular physical activity could play a role in helping women at high-risk of breast cancer delay the need for drastic preventive measures such as mastectomy. Results of the WISER Sister study help clarify the emerging connection between exercise and breast cancer risk. As a result of the new findings, the authors suggest women with an elevated breast cancer risk should consider doing 30 to 60 minutes of aerobic activity per day for five days per week.
National Institutes of Health

Contact: Katie Delach
University of Pennsylvania School of Medicine

Public Release: 29-Oct-2015
Cell Stem Cell
Factor found to balance medically useful stem cell qualities
A key protein controls stem cell properties that could make them more useful in regenerative medicine, according to a study led by Mount Sinai researchers and published online today in the journal Cell Stem Cell.
Ellison Medical Foundation Senior Scholar Award in Aging, National Institutes of Health, New York State Department of Health/Empire State Stem Cell Fund

Contact: Press Office
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 29-Oct-2015
Researchers discover new way to measure if a person is pre-diabetic
This discovery by University of Hawai'i Cancer Center researchers may allow physicians to warn patients years before the onset of diabetes, therefore allowing them to change their lifestyle patterns potentially avoiding the diagnosis of a chronic disease.

Contact: Nana Ohkawa
University of Hawaii Cancer Center

Public Release: 29-Oct-2015
Nature Cell Biology
Nuclear membrane repairs the 'dark matter' of DNA
The nuclear membrane isn't just a protective case around the nucleus -- it actually repairs catastrophically broken DNA strands.
USC Gold Family Fellowship, USC Research Enhancement Fellowship, USC Provost Fellowship, Rose Hills Foundation, National Institute of Health

Contact: Robert Perkins
University of Southern California

Showing releases 176-200 out of 1253.

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