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Showing releases 176-200 out of 1266.

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Public Release: 11-Feb-2015
Nature Communications
One-two punch catches cancer cells in vulnerable state
Timing may be decisive when it comes to overcoming cancer's ability to evade treatment. By hitting breast cancer cells with a targeted therapeutic immediately after chemotherapy, researchers from Brigham and Women's Hospital were able to target cancer cells during a transitional stage when they were most vulnerable, killing cells and shrinking tumors in the lab and in pre-clinical models. The team reports its findings in Nature Communications on Feb. 11.
US Department of Defense, National Institutes of Health, American Lung Association, Indo-US Science and Technology Forum, American Cancer Society

Contact: Haley Bridger
hbridger@partners.org
617-525-6383
Brigham and Women's Hospital

Public Release: 11-Feb-2015
New England Journal of Medicine
Education, not mandatory screening, best for women with dense breast tissue
Women with dense breast tissue are at increased risk of breast cancer. Dense breast tissue, generally defined as having more fibroglandular than fatty tissue, can make it more difficult for radiologists to detect cancer on screening mammography.

Contact: Jerry Berger
jberger@bidmc.harvard.edu
617-667-7308
Beth Israel Deaconess Medical Center

Public Release: 11-Feb-2015
New England Journal of Medicine
Order matters: Sequence of genetic mutations determines how cancer behaves
The order in which genetic mutations are acquired determines how an individual cancer behaves, according to research from the University of Cambridge, published today in the New England Journal of Medicine.
Leukaemia and Lymphoma Research, Cancer Research UK, Kay Kendall Leukaemia Fund, NIHR Cambridge Biomedical Research Centre, Cambridge Experimental Cancer Medicine Centre, Leukemia & Lymphoma Society of America, Canadian Institutes of Health Research

Contact: Craig Brierley
craig.brierley@admin.cam.ac.uk
44-012-237-66205
University of Cambridge

Public Release: 11-Feb-2015
PLOS ONE
Twelve-year study suggests procedures to prevent cervical cancer do not affect fertility
Common surgical procedures used to diagnose and treat precancerous cervical lesions do not decrease women's chances of becoming pregnant, according to a study that followed nearly 100,000 women for up to 12 years. To the contrary, researchers found that women who had one of these procedures were actually more likely to become pregnant than women who did not have a procedure. The new Kaiser Permanente study is published today in PLOS ONE.
GSK

Contact: Cyrus Hedayati
chedayati@golin.com
415-318-4377
Kaiser Permanente

Public Release: 10-Feb-2015
Journal of Clinical Oncology
Smaller pre-surgery radiation targets reduces long term side effects, not survival rates
The Journal of Clinical Oncology just published clinical trial results that more firmly establish that for patients with soft tissue sarcomas, image-guided radiation directed towards a smaller target area great reduced long term negative impact without effecting survival rates.
NRG Oncology

Contact: Charles Jolie
Charles_L_Jolie@Rush.edu
312-942-7817
Rush University Medical Center

Public Release: 10-Feb-2015
British Journal of Cancer
90 percent approve of cancer screening but screening uptake is lower
Nine in 10 people think that cancer screening is 'almost always a good idea' despite the fact that screening uptake is lower, a Cancer Research UK study in the British Journal of Cancer shows.

Contact: Emily Head
emily.head@cancer.org.uk
020-346-96189
Cancer Research UK

Public Release: 10-Feb-2015
Addiction
Plain packaging reduces 'cigarette-seeking' response by almost 10 percent, says study
Plain tobacco packaging may reduce the likelihood of smokers seeking to obtain cigarettes by almost 10 percent compared to branded packs, according to research from the universities of Exeter and Bristol.
British Heart Foundation, Cancer Research UK, Economic and Social Research Council, Medical Research Council, National Institute for Health Research

Contact: Eleanor Gaskarth
e.f.gaskarth@hotmail.com
44-078-794-33087
University of Exeter

Public Release: 10-Feb-2015
Developmental Cell
Epigenetic breakthrough: A first of its kind tool to study the histone code
University of North Carolina scientists have created a new research tool, based on the fruit fly, to help crack the histone code. This research tool can be used to better understand the function of histone proteins, which play critical roles in the regulation of gene expression in animals and plants.
National Institutes of Health, University of North Carolina

Contact: Mark Derewicz
mark.derewicz@unchealth.unc.edu
919-923-0959
University of North Carolina Health Care

Public Release: 10-Feb-2015
Molecular Cancer Therapeutics
Lung cancer may be treatable with use of SapC-DOPS technology, research shows
A University of Cincinnati study, published in the advance online edition of the journal Molecular Cancer Therapeutics, provides hope that the therapeutic agent SapC-DOPS could be used for treatment of this cancer.
NIH/National Cancer Institute, New Drug State Key Project, University of Cincinnati College of Medicine

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center

Public Release: 10-Feb-2015
Journal of Thoracic Oncology
Mesothelioma in southern Nevada likely result of asbestos in environment
Malignant mesothelioma has been found at higher than expected levels in women and in individuals younger than 55 years old in the southern Nevada counties of Clark and Nye, likewise in the same region carcinogenic mineral fibers including actinolite asbestos, erionite, winchite, magnesioriebeckite and richterite were discovered. These data suggest that these elevated numbers of malignant mesothelioma cases are linked to environmental exposure of carcinogenic mineral fibers.

Contact: Murry Wynes
Murry.Wynes@iaslc.org
720-325-2945
International Association for the Study of Lung Cancer

Public Release: 10-Feb-2015
Journal of Thoracic Oncology
Not all EGFR mutations are the same when it comes to therapy for NSCLC
Certain rare epidermal growth factor receptor mutations are associated with tobacco smoking, worse prognosis and poor response to EGFR tyrosine kinase inhibitor therapy compared to the more common 'classical' EGFR mutations. However, as not all rare mutations are the same, testing and therapy may need to be evaluated for each individual mutation.

Contact: Murry Wynes
Murry.Wynes@iaslc.org
720-325-2945
International Association for the Study of Lung Cancer

Public Release: 10-Feb-2015
Stem Cell Reports
New reporter system to study bone-related regenerative medicine generated by UMN labs
A new reporter system used to study the bone regeneration potential of human embryonic stem cells has been generated in research led by the University of Minnesota. The new reporter system is the first of its kind for human pluripotent stem cells and is important for identifying certain agents and pathways that mediate early stages of human bone development. The research is published today in the journal Stem Cell Reports.

Contact: Miranda Taylor
tayl0551@umn.edu
612-626-2767
University of Minnesota Academic Health Center

Public Release: 10-Feb-2015
Journal of Thoracic Oncology
The NELSON lung cancer screening trial results are inferable for the general high-risk
Results of the NELSON lung cancer screening trial using low dose computed tomography can be used to predict the effect of population-based screening on the Dutch population even though there were slight differences in baseline characteristics of participants in the control arm versus eligible non-participants.

Contact: Murry Wynes
Murry.Wynes@iaslc.org
720-325-2945
International Association for the Study of Lung Cancer

Public Release: 9-Feb-2015
Cancer Epidemiology, Biomarkers & Prevention
Previously unknown genomic regions found in African American families with breast cancer
Study led by University at Buffalo has uncovered previously unknown segments of DNA shared by African American family members who have breast cancer. The discovery of these regions supports our hypothesis that there are still undiscovered breast cancer genes that may be unique to African and spurs researchers to focus on these specific chromosomes to learn if they house genetic mutations linked to breast cancer
Susan Komen for the Cure Foundation

Contact: Pat Donovan
pdonovan@buffalo.edu
716-645-4602
University at Buffalo

Public Release: 9-Feb-2015
Nature Genetics
Keck Medicine of USC researchers trace origins of colorectal cancer tumor cells
For the first time, Keck Medicine of the University of Southern California cancer researchers have traced the origins of colorectal cancer cells, finding important clues to why tumor cells become 'good' or 'bad,' with the potential of stopping them before they start.
National Cancer Institute, The V Foundation for Cancer Research

Contact: Leslie Ridgeway
lridgewa@usc.edu
323-442-2823
University of Southern California - Health Sciences

Public Release: 9-Feb-2015
Cancer Epidemiology, Biomarkers, and Prevention
Study links new genetic anomalies to breast cancer in African-American families
Researcher Heather Ochs-Balcom says, 'Our family-based gene hunt is similar to the groundbreaking study among women with European ancestry done in the early 1990s that led to the discovery of BRCA1 and BRCA2 gene mutations, which greatly increase susceptibility to breast and ovarian cancer.'

Contact: Patricia Donovan
pdonovan@buffalo.edu
716-645-4602
University at Buffalo

Public Release: 9-Feb-2015
Nature Genetics
Inherited gene variations tied to treatment-related hearing loss in cancer patients
St. Jude Children's Research Hospital investigators have discovered inherited genetic variations that are associated with rapid hearing loss in young cancer patients treated with the drug cisplatin. The research appears in the current online issue of the scientific journal Nature Genetics.
National Institutes of Health, ALSAC

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Public Release: 9-Feb-2015
Journal of Experimental Medicine
How tumor-causing cells are recruited in cancers linked to chronic inflammation
Chronic inflammation is directly associated with several types of cancer, yet the reasons as to why this happens at a cellular level remain unclear. Now, an international team of scientists led by researchers at The Wistar Institute has identified a multistep process showing not only how these cancers develop but also potentially discovering new therapeutic targets that could halt the formation and progression of tumor cells.
National Institutes of Health

Contact: Ben Leach
bleach@wistar.org
215-495-6800
The Wistar Institute

Public Release: 9-Feb-2015
Journal of Clinical Investigation
Cancer's ability to 'hijack' regulatory mechanism increases metastasis
When skyscrapers go up, contractors rely on an infrastructure of steel beams and braces. Some cancers grow the same way, using a biological matrix from which the tumor can thrive and spread.

Contact: Ron Gilmore
rlgilmore1@mdanderson.org
713-745-1898
University of Texas M. D. Anderson Cancer Center

Public Release: 9-Feb-2015
Journal of National Cancer Institute
Study finds no reason for cancer survivors to be excluded in advanced stage lung cancer trials
The common practice of excluding patients with a prior cancer diagnosis from lung cancer clinical trials may not be justified, according to a study by researchers from UT Southwestern Medical Center.

Contact: Lori Sundeen Soderbergh
lori.soderbergh@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 9-Feb-2015
Cell Metabolism
Griffith research unlocks more about cancer
Ground-breaking research from Griffith University on the Gold Coast has some scientists wondering if the entire study of cellular biology needs to be adjusted.
Malaghan Institute of New Zealand, Griffith University

Contact: Louise Durack
l.durack@griffith.edu.au
041-964-9516
Griffith University

Public Release: 9-Feb-2015
Nature Communications
New screening tool could speed development of ovarian cancer drugs
Researchers have built a model system that uses multiple cell types from patients to rapidly test compounds that could block the early steps in the spread of ovarian cancer. Their 3-D cell culture system has enabled them to identify small molecules that can inhibit adhesion and invasion, hallmarks of cancer metastasis.
Bears Care, National Institutes of Health, NIH/National Cancer Institute, NIH/National Institute of Neurological Disorders and Stroke

Contact: John Easton
John.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center

Public Release: 9-Feb-2015
Clinical Cancer Research
Could there be a gleevec for brain cancer?
The drug Gleevec (imatinib mesylate) is well known not only for its effectiveness against chronic myeloid leukemia (CML) and acute lymphoblastic leukemia, but also for the story behinds its development. The drug was specifically designed to target an abnormal molecule--a fusion of two normal cell proteins--that fueled a tumor's growth.
NIH/National Institute of Neurological Disorders and Stroke

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center

Public Release: 9-Feb-2015
ASTRO applauds CMS's decision to cover annual, LDCT screening for high-risk lung cancer patients
The American Society for Radiation Oncology commends the Febr. 5, 2015, decision by the Centers for Medicare and Medicaid Services to provide coverage for annual lung cancer screening via low-dose CT screening for those at highest-risk for lung cancer.

Contact: Michelle Kirkwood
michellek@astro.org
703-286-1600
American Society for Radiation Oncology

Public Release: 9-Feb-2015
Annals of Internal Medicine
Lung screening guidelines improve on study findings
A set of guidelines developed to help standardized lung cancer screening would have generated considerably fewer false-positives than the National Lung Screening Trial produced, according to a new retrospective study.
National Institutes of Health

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Showing releases 176-200 out of 1266.

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