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Showing releases 176-200 out of 1341.

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Public Release: 9-May-2016
Annals of Internal Medicine
MRI stronger predictor of major adverse cardiovascular events than standard scan
Cardiovascular magnetic resonance (CMR) is a stronger predictor of risk for major adverse cardiovascular events (MACE) than single-photon emission computed tomography (SPECT) at 5 years follow-up. The findings are published in Annals of Internal Medicine.

Contact: Angela Collom
American College of Physicians

Public Release: 9-May-2016
Nature Genetics
Discovery of lung cancer mutations responsive to targeted therapies and to immunotherapies
Researchers from several major US universities and ITMO University in Russia have identified a number of new driver mutations in lung cancer cells that may be responsive to genomically targeted therapies and to immunotherapy.
NIH/National Cancer Institute, US Department of Defense, American Cancer Society Research

Contact: Dmitry Malkov
ITMO University

Public Release: 9-May-2016
Cancer Cell
Experimental therapy halts treatment-resistant brain tumors
Researchers report in the journal Cancer Cell an experimental therapy that in laboratory tests stops aggressive, treatment-resistant and deadly brain cancers called glioblastoma and high-grade gliomas. A multi-institutional team led by researchers at Cincinnati Children's Hospital Medical Center publishes their results on May 9. Testing a multi-step therapeutic strategy, the scientists found a way to use a gene therapy to shut down a gene long-implicated in the formation of high-grade gliomas called Olig2.

Contact: Nick Miller
Cincinnati Children's Hospital Medical Center

Public Release: 9-May-2016
Cancer may drive health problems as people age
A new study indicates that cancer may have negative impacts on both the physical and mental health of individuals as they age. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study suggests that cancer increases the risk for certain health issues above and beyond normal aging.

Contact: Dawn Peters

Public Release: 9-May-2016
BMJ Open
Radiotherapy during surgery could save millions of travel miles and tons of CO2
One targeted dose of radiotherapy given during surgery to remove early stage breast cancer could save millions of travel miles, enough CO2 emissions for a 100 hectare forest, and free up thousands of hours of women's time, concludes research published in the online journal BMJ Open.

Contact: Caroline White

Public Release: 9-May-2016
Proceedings of the National Academy of Sciences
Scripps Florida scientists pioneer a breakthrough approach to breast cancer treatment
In a development that could lead to a new generation of drugs to precisely treat a range of diseases, scientists from the Florida campus of The Scripps Research Institute have for the first time designed a drug candidate that decreases the growth of tumor cells in animal models in one of the hardest to treat cancers -- triple negative breast cancer.
National Institutes of Health, The Nelson Fund for Therapeutic Development

Contact: Eric Sauter
Scripps Research Institute

Public Release: 9-May-2016
Cancer Cell
International collaboration for genome analysis leads to clues about rare cancer
An international team of researchers through The Cancer Genome Atlas Network uncovered double the number of genetic drivers already known to fuel adrenal cancer.
National Institutes of Health

Contact: Nicole Fawcett
University of Michigan Health System

Public Release: 7-May-2016
2016 American Urological Association Annual Meeting
Study suggests testosterone therapy does not raise risk of aggressive prostate cancer
Men with low levels of the male sex hormone testosterone need not fear that testosterone replacement therapy will increase their risk of prostate cancer.

Contact: David March
NYU Langone Medical Center / New York University School of Medicine

Public Release: 6-May-2016
Science Advances
Peptide payload
Erkki Ruoslahti and colleagues provide proof of principle for safe, targeted delivery of drugs to the placenta during pregnancy.

Contact: Julie Cohen
University of California - Santa Barbara

Public Release: 6-May-2016
Current Computer-Aided Drug Design
Quantum chemical computations provide insight into liver toxicity
By systematic computational studies on 55 hydrocarbons Balasubramanian and Basak have ranked the toxicity of halocarbons on the basis of the electron affinity and proton-extraction propensity from the lipid membrane of the liver.

Contact: Faizan ul Haq
Bentham Science Publishers

Public Release: 5-May-2016
Scientific Reports
Sylvester researchers develop novel disease model to study multiple myeloma
Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have developed an animal model that allows them to better understand the mechanisms that lead to the development of multiple myeloma, a hematologic cancer of plasma cells, and the amyloidosis that sometimes accompanies it.
National Institutes of Health, Geoffrey Beene Foundation, Mel Stottlemyre Multiple Myeloma Fund, Norma and Gordon Smith Cancer Research Foundation

Contact: Patrick Bartosch
University of Miami Miller School of Medicine

Public Release: 5-May-2016
Nature Communications
Pond scum and the gene pool: A critical gene in green algae responsible for multicellularity
Brad Olson, assistant professor in the Division of Biology; Erik Hanschen, doctoral student at the University of Arizona; Hisayoshi Nozaki, University of Tokyo; and an international team of researchers found a single gene is responsible for the evolution of multicellular organisms and may be a possible origin of cancer.
National Science Foundation, National Institutes of Health, Kansas State University's Johnson Cancer Research Center

Contact: Brad Olson
Kansas State University

Public Release: 5-May-2016
The Annals of Thoracic Surgery
Older lung cancer patients experience excellent survival following surgery
Newly combined data offers a longer-term perspective on an increasingly growing population.

Contact: Jennifer Bagley

Public Release: 5-May-2016
Journal of Biological Chemistry
Starving cancer the key to new treatments
Researchers have identified a vital supply route that cancer cells use to obtain their nutrients, in a discovery that could lead to new treatments to stop the growth of tumors. The research team blocked gateways through which the cancer cell was obtaining the amino acid glutamine and found the cells almost completely stopped growing.

Contact: Professor Stefan Broer
Australian National University

Public Release: 5-May-2016
The Journals of Gerontology: Series B
Study contradicts belief that cancer protects against Alzheimer's
Despite studies that claim people with cancer are less likely to develop Alzheimer's disease -- raising the possibility that what triggers cancer also prevents the neurodegenerative disorder -- a new investigation finds a more somber explanation. Many cancer patients don't live long enough to get Alzheimer's. The research, led by investigators at Huntsman Cancer Institute at the University of Utah, was published in The Journals of Gerontology: Series B.
National Institutes of Health, Huntsman Cancer Institute

Contact: Linda Aagard
University of Utah Health Sciences

Public Release: 5-May-2016
Tension-sensitive molecule helps cells divide chromosomes accurately
A tension-sensitive 'fail safe' protein helps make sure that when our cells divide the two resulting cells inherit the normal number of chromosomes. Chromosome separation errors, leading to too few or too many chromosomes, is the most common genetic abnormality in cancer cells. This latest finding in cell division biology may guide the development of new chemotherapeutic drugs that target the machinery of cell division.
National Institutes of Health, Packard, Howard Hughes Medical Institute

Contact: Michael McCarthy
University of Washington Health Sciences/UW Medicine

Public Release: 5-May-2016
American Journal of Human Genetics
Testing non-breast cancer genes in high-risk women leaves more questions than answers
Running large, multi-gene sequencing panels to assess cancer risk is a growing trend in medicine as the price of the technology declines and more precise approaches to cancer care gain steam. The tests are particularly common among breast and ovarian cancer patients. However, questions remain about the growing list of mutations and their suspected, but unproven association with breast and ovarian cancer risk.
National Institutes of Health, US Department of Defense, American Society of Clinical Oncology, Breast Cancer Research Foundation, Rooney Family Foundation, Commonwealth of Pennsylvania

Contact: Steve Graff
University of Pennsylvania School of Medicine

Public Release: 5-May-2016
JAMA Surgery
Improvements to online health information can help reduce barriers to care for pancreatic cancer
New research from Beth Israel Deaconess Medical Center published today in JAMA Surgery suggests that online information about pancreatic cancer is often written at a prohibitively high reading level and lacks accuracy concerning alternative therapies.
Alliance of Families Fighting Pancreatic Cancer, Griffith Family Foundation

Contact: Kelly Lawman
Beth Israel Deaconess Medical Center

Public Release: 5-May-2016
Journal of Clinical Sleep Medicine
Study links sleep duration and frequent snoring to poorer breast cancer survival
A new study reports that short sleep duration combined with frequent snoring reported prior to cancer diagnosis may influence subsequent breast cancer survival.
NIH/National Cancer Institute

Contact: Amy Pyle
American Academy of Sleep Medicine

Public Release: 5-May-2016
JCI Insight
Protein may predict response to immunotherapy in patients with metastatic melanoma
A protein called Bim may hold the clue to which patients may be successful on immunotherapy for metastatic melanoma, according to the results of a study by Mayo Clinic researchers led by senior author Haidong Dong, M.D., Ph.D., and published online in the May 5 edition of JCI Insight.
Cancer Research Institute, NIH/National Cancer Institute, NIH/National Institute of Allergy and Infectious Diseases, Mayo Clinic/Center for Individualized Medicine Biomarker Discovery Program

Contact: Joe Dangor
Mayo Clinic

Public Release: 5-May-2016
2016 Annual Meeting of the American Association for Cancer Research (AACR)
Preliminary results comparing PD-L1 IHC diagnostic assays in lung cancer released
A pre-competitive consortia of pharmaceutical companies, diagnostic companies, and academic associations, including the International Association for the Study of Lung Cancer (IASLC), announced phase I results of the 'BLUEPRINT PD-L1 IHC ASSAY COMPARISON PROJECT' at the Annual Meeting of the American Association for Cancer Research (AACR) on April 19. The study compared four PD-L1 IHC diagnostic assays developed in conjunction with four PD-1/PD-L1 immune checkpoint inhibitors, which are used in NSCLC clinical trials.

Contact: Jeff Wolf
International Association for the Study of Lung Cancer

Public Release: 5-May-2016
Proceedings of the National Academy of Sciences
T cells use 'handshakes' to sort friends from foes
Chemists provide the first direct evidence that a T cell gives precise mechanical tugs to other cells, and demonstrate that these tugs are central to a T cell's process of deciding whether to mount an immune response.
National Institutes of Health, Alfred P. Sloan Research Fellowship, Camille Dreyfus Teacher-Scholar Award, National Science Foundation, National Multiple Sclerosis Society

Contact: Carol Clark
Emory Health Sciences

Public Release: 5-May-2016
Cell Reports
Research findings reveal potential to reverse cancer-related nerve pain
A study providing new information about neuropathic pain afflicting some 90 percent of cancer patients who have had nerve damage caused by tumors, surgery, chemotherapy or radiation indicates gene therapy as a possible treatment.

Contact: Ron Gilmore
University of Texas M. D. Anderson Cancer Center

Public Release: 5-May-2016
2016 Experimental Biology Conference
FASEB Journal
Emerging research investigates mango's health properties
Four new studies surrounding the effects of mango consumption suggest this superfruit has the potential to help combat adverse effects associated with high fat diets and obesity (animal study), as well inhibit growth of fat cells (anti-lipogenic properties in an in-vivo study), slow advancement of breast cancer tumors (animal study), as well as improve regularity and decrease inflammation associated with constipation (human subject study). The research was presented at the 2016 Experimental Biology conference in San Diego.
National Mango Board

Contact: Meghan Flynn
Wild Hive

Public Release: 5-May-2016
Cell Reports
Study points to therapeutic target for common and aggressive ovarian cancer
Small, non-coding molecules called microRNAs are known to play an important role in cancer development.

Contact: Ron Gilmore
University of Texas M. D. Anderson Cancer Center

Showing releases 176-200 out of 1341.

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