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Showing releases 176-200 out of 1317.

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Public Release: 30-Apr-2015
Journal of Steroid Biochemistry and Molecular Biology
Pancreatic cancer risk linked to weak sunlight
Writing in the April 30 online issue of the Journal of Steroid Biochemistry and Molecular Biology, researchers at University of California San Diego School of Medicine report pancreatic cancer rates are highest in countries with the least amount of sunlight. Low sunlight levels were due to a combination of heavy cloud cover and high latitude.
UC San Diego Department of Family Medicine and Public Health

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 30-Apr-2015
EBioMedicine
Telomere changes predict cancer
A distinct pattern in the changing length of blood telomeres, the protective end caps on our DNA strands, can predict cancer many years before actual diagnosis, a new study shows. The pattern, which spanned 13 years before cancer diagnosis, could yield a new biomarker to predict cancer development with a blood test. This is the first reported trajectory of telomere changes over the years in people developing cancer.
National Institutes of Health

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University

Public Release: 30-Apr-2015
Cell Reports
Protein in metabolic reprogramming restrains senescent cells from becoming cancerous
In recent years, research has shown that cancerous cells have a different metabolism -- essential chemical and nutritional changes needed for supporting the unlimited growth observed in cancer- than normal cells. Now, scientists at The Wistar Institute have identified a way that cells can reprogram their metabolism to overcome a tumor-suppressing mechanism known as senescence, solidifying the notion that altered metabolism is a hallmark of cancer progression.
National Institutes of Health, US Department of Defense

Contact: Ben Leach
bleach@wistar.org
215-495-6800
The Wistar Institute

Public Release: 30-Apr-2015
Annals of Internal Medicine
ACP releases best practice advice for cervical cancer screening
New clinical advice from the American College of Physicians aims to reduce overuse of cervical cancer screening in average risk women without symptoms.

Contact: Megan Hanks
mhanks@acponline.org
215-351-2656
American College of Physicians

Public Release: 30-Apr-2015
The International Liver Congress 2015
Study results promising for hepatitis C patients awaiting or completing liver transplant
Hepatitis C patients who are awaiting a liver transplant or have completed one are a difficult group to cure because hepatitis C can come back after transplant. The ALLY-1 trial, led by Fred Poordad, M.D., showed that a large number of these patients can be cured with an oral regimen of daclatasvir, sofosbuvir and ribavirin. Treatment was well tolerated with few serious side effects.
Bristol-Myers Squibb

Contact: Rosanne Fohn
fohn@uthscsa.edu
210-567-3026
University of Texas Health Science Center at San Antonio

Public Release: 30-Apr-2015
BMJ Open
Substantial benefits for health and environment through realistic changes to UK diets
Making a series of relatively minor and realistic changes to UK diets would not only reduce UK diet-related greenhouse gas emissions by nearly a fifth, but could also extend average life expectancy by eight months, according to new research led by the London School of Hygiene & Tropical Medicine.
European Union

Contact: Jenny Orton
press@lshtm.ac.uk
44-020-792-72802
London School of Hygiene & Tropical Medicine

Public Release: 30-Apr-2015
Annals of Internal Medicine
ACP releases advice for the proper time, test, and interval for cervical cancer screening
The American College of Physicians today released clinical advice aimed at reducing overuse of cervical cancer screening in average risk women without symptoms. 'Cervical Cancer Screening in Average Risk Women' is published in Annals of Internal Medicine and lists two concurring organizations: the American Congress of Obstetricians and Gynecologists and the American Society for Clinical Pathology.

Contact: Steve Majewski
SMajewski@mail.acponline.org
American College of Physicians

Public Release: 30-Apr-2015
Science
New origin theory for cells that gave rise to vertebrates
Zebras' vivid pigmentation and the fight or flight instinct. These and other features of the world's vertebrates stem from neural crest cells, but little is known about their origin. Northwestern University scientists propose a new model for how neural crest cells, and thus vertebrates, arose more than 500 million years ago. They report that these cells retain the molecular underpinnings that control pluripotency -- the ability to give rise to all the cell types that make up the body.
National Institutes of Health

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University

Public Release: 30-Apr-2015
Molecular Cell
Vital step in stem cell growth revealed
Salk scientists' finding could aid regenerative and cancer therapies.

Contact: Salk Communications
press@salk.edu
Salk Institute

Public Release: 30-Apr-2015
Journal of Biological Chemistry
Moffitt researchers discover new mechanism controlling cell response to DNA damage
DNA can be damaged by different environmental insults, such as ultraviolet light, ionizing radiation, oxidative stress or certain drugs. If the DNA is not repaired, cells may begin growing uncontrollably, leading to the development of cancer. Therefore, cells must maintain an intricate regulatory network to ensure that their DNA remains intact. Moffitt Cancer Center researchers have discovered a novel mechanism that controls a cell's response to DNA damage.
National Institutes of Health, James & Esther King Biomedical Research Program

Contact: Kim Polacek
Kim.Polacek@Moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 30-Apr-2015
EBioMedicine
U of M institute discovers how aspirin fights cancer
Taking aspirin reduces a person's risk of colorectal cancer, but the molecular mechanisms involved have remained unknown until a recent discovery by The Hormel Institute, University of Minnesota.

Contact: Tim Ruzek
truzek@hi.umn.edu
507-437-9601
University of Minnesota

Public Release: 30-Apr-2015
Journal of Leukocyte Biology
Pre-existing inflammation may promote the spread of cancer
A new research report appearing in the May 2015 issue of the Journal of Leukocyte Biology suggests that allergic reactions -- or at least the pre-existing inflammation from these reactions -- may set the stage for cancer to spread from one area to another.

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-938-6827
Federation of American Societies for Experimental Biology

Public Release: 30-Apr-2015
Proceedings of the National Academy of Sciences
Compact synchrotron makes tumors visible
Soft tissue disorders like tumors are very difficult to recognize using normal X-ray machines. There is hardly any distinction between healthy tissue and tumors. Researchers at the Technische Universität München have now developed a technology using a compact synchrotron source that measures not only X-ray absorption, but also phase shifts and scattering. Tissue that is hardly recognizable using traditional X-ray machines is now visible.
German Research Foundation/Cluster of Excellence Munich-Centre for Advanced Photonics, European Research Council, NIH/National Institute of General Medical Sciences, National Center for Research Resources, Helmholz Center NanoMikro, and others

Contact: Dr. Andreas Battenberg
battenberg@zv.tum.de
49-892-891-0510
Technische Universitaet Muenchen

Public Release: 29-Apr-2015
New England Journal of Medicine
NEJM reports promising results of phase 1/2 trial of rociletinib in EGFR lung cancer
The New England Journal of Medicine reports results of a multi-center phase I/II study of the investigational anti-cancer agent rociletinib in patients with EGFR-mutant non-small cell lung cancer that had progressed after previous treatment with EGFR inhibitors. Responses were seen in 59 percent of evaluable patients with the T790M mutation. In this same population, median progression-free survival at the time of analysis was 13.1 months.

Contact: Garth Sundem
garth.sundem@ucdenver.edu
805-559-2023
University of Colorado Denver

Public Release: 29-Apr-2015
95th Annual American Association for Thoracic Surgery Meeting
Five-year survivors of esophageal cancer still face low but constant risks
In 2015 about 17,000 new cases of esophageal cancer will be diagnosed; about 15,600 people will die from the disease. While the five-year survival rate in the 1960s and 1970s was only about 5 percent, improvements in diagnosis, treatment, and management have led to improved survival. A presentation at the AATS Annual Meeting shows that while five-year survival is up to 39 percent, these patients still face many health risks and should be monitored for 10 years or more.

Contact: Nicole Baritot
press@aats.org
978-299-4520
American Association for Thoracic Surgery

Public Release: 29-Apr-2015
New England Journal of Medicine
Rociletinib shows promising activity against treatment-resistant EGFR-mutated lung cancer
A new targeted therapy drug against EGFR-mutation driven lung tumors that have become resistant to current therapies shows activity against the most common resistance mutation, significantly improving outcomes for patients. Results of the phase I/II clinical trial of rociletinib (previously known as CO-1686) are being published in the April 30 New England Journal of Medicine.
Clovis Oncology

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital

Public Release: 29-Apr-2015
CNS Oncology
Brain tumor patients should be screened for depression
Because depression in brain cancer patients is a common but often overlooked condition, oncologists should regularly screen tumor patients for depression, according to an article in the current issue of CNS Oncology. The journal is published by Future Medicine, an imprint of Future Science Group.

Contact: Leela Ripton
l.ripton@future-science-group.com
44-208-371-6090
Future Science Group

Public Release: 29-Apr-2015
Science Translational Medicine
New therapy from naïve cells attacks high-risk viruses in cord blood transplant patients
Researchers in the Center for Cell and Gene Therapy at Baylor College of Medicine, Houston Methodist and the Texas Children's Hospital have expanded the use of virus-specific cell therapy in cord blood transplant patients to successfully prevent three of the most problematic post-transplant viruses affecting this group of patients that have yet to be addressed clinically -- cytomegalovirus, Epstein-Barr virus, and adenovirus.

Contact: Glenna Vickers
picton@bcm.edu
713-798-4710
Baylor College of Medicine

Public Release: 29-Apr-2015
Nature
Combined chemotherapy and immunotherapy shows promise for advanced prostate cancers
Researchers at the University of California, San Diego School of Medicine report that blocking or removing immune-suppressing cells allows a special type of chemotherapy -- and the immune cells it activates -- to destroy prostate tumors. This novel combination therapy, termed chemoimmunotherapy, achieved near complete remission in mouse models of advanced prostate cancer. The study is published April 29 in Nature.
National Institutes of Health, California Institute for Regenerative Medicine, German Research Foundation, Genome Research-Austria and Cancer Research Institute

Contact: Heather Buschman
hbuschman@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 29-Apr-2015
ecancermedicalscience
Preventive gynecology special issue honors memory of deceased pioneer
The special issue, 'Prevention of gynecological cancers: in memory of Mario Sideri,' consists of nine articles centered around Dr. Sideri's favored research topic. Dr. Sideri was one of the first doctors in the world to identify the connection between the human papillomavirus and cervical cancer.

Contact: Audrey Nailor
audrey@ecancer.org
44-011-790-94742
ecancermedicalscience

Public Release: 29-Apr-2015
Nature Cell Biology
UTSW scientists identify key receptors behind development of acute myeloid leukemia
UT Southwestern Medical Center scientists have discovered that a certain class of receptors that inhibit immune response are crucial for the development of acute myeloid leukemia, the most common acute leukemia affecting adults.
National Institutes for Health, Leukemia & Lymphoma Society, March of Dimes Foundation, Robert A. Welch Foundation, When Everyone Survives Foundation, V Foundation for Cancer Research, William Lawrence and Blanche Hughes Fund, and others

Contact: Lori Sundeen Soderbergh
lori.soderbergh@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 29-Apr-2015
Nature Communications
Uncovering new functions of a gene implicated in cancer growth opens new therapeutic possibilities
Weill Cornell Medical College researchers have shown for the first time that a gene previously implicated in blood vessel formation during embryonic development and tumor growth also induces immune suppression during tumor development. This finding, published April 29 in Nature Communications, opens the door for new therapeutic approaches and vaccine development in treating patients with melanoma and other advanced-staged cancers.

Contact: Jen Gundersen
jeg2034@med.cornell.edu
646-317-7401
Weill Cornell Medical College

Public Release: 29-Apr-2015
Journal of Adolescent and Young Adult Oncology
Breast cancer in young women -- unique goals for treatment and research
Breast cancer that occurs in young women is likely to be more aggressive and to require more intensive types of therapy with increased risk of long-term treatment-related toxicities. The unique and significant challenges and psychosocial concerns that women under 40 years of age with breast cancer face are discussed in a special article published in Journal of Adolescent and Young Adult Oncology.

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 29-Apr-2015
Nature Communications
University of Louisville researchers detail role of silica and lung cancer
Researchers at the University of Louisville have detailed a critical connection associated with a major environmental cause of silicosis and a form of lung cancer. Their study is reported in today's Nature Communications.

Contact: Gary Mans
gary.mans@louisville.edu
502-852-7504
University of Louisville

Public Release: 29-Apr-2015
Journal of National Cancer Institute
Danish discovery may change cancer treatment
Danish researchers from the University of Copenhagen and Herlev Hospital have made a discovery that may change the principles for treating certain types of cancer.

Contact: Stig Bojesen
stig.egil.bojesen@regionh.dk
45-61-79-71-51
University of Copenhagen - The Faculty of Health and Medical Sciences

Showing releases 176-200 out of 1317.

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