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Showing releases 201-225 out of 1382.

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Public Release: 26-Jul-2016
Journal of Cell Biology
UMD researchers discover a way that animals keep their cells identical
A University of Maryland research team is the first to discover that a regulatory protein named ERI-1 helps ensure that all cells in a tissue remain identical to one another. The work involved an unusual collaboration between developmental biologists and linguists, with the latter contributing their expertise with machine learning software. The finding could bring biologists one step closer to understanding some cancers and other age-related diseases.
Howard Hughes Medical Institute, National Institutes of Health

Contact: Matthew Wright
mewright@umd.edu
301-405-9267
University of Maryland

Public Release: 26-Jul-2016
JAMA
Evidence insufficient to make recommendation regarding visual skin examination by a clinician
The US Preventive Services Task Force (USPSTF) has concluded that the current evidence is insufficient to assess the balance of benefits and harms of visual skin examination by a clinician to screen for skin cancer in asymptomatic adults. The report appears in the July 26 issue of JAMA.

Contact: Media Coordinator
Newsroom@USPSTF.net
202-572-2044
The JAMA Network Journals

Public Release: 26-Jul-2016
Bone Marrow Transplantation
Cord blood outperforms matched, unrelated donor in bone marrow transplant
A University of Colorado Cancer Center study finds that three years post-bone marrow transplant, the incidence of severe chronic graft-versus-host disease was 44 percent in patients who had received transplants from matched, unrelated donors (MUD) and 8 percent in patients who had received umbilical cord blood transplants (CBT).

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Anschutz Medical Campus

Public Release: 26-Jul-2016
EBioMedicine
Markers that cause toxic radiotherapy side-effects in prostate cancer identified
A new study involving researchers from The University of Manchester looked at the genetic information of more than 1,500 prostate cancer patients and identified two variants linked to increased risk of radiotherapy side-effects.

Contact: Jamie Brown
jamie.brown@manchester.ac.uk
44-161-275-8383
University of Manchester

Public Release: 26-Jul-2016
JAMA
Task force maybe too stringent in not yet recommending melanoma screening
In an editorial in JAMA, two experts including Brown University dermatologist Dr. Martin Weinstock question a USPSTF determination that there isn't enough evidence to recommend that clinicians visual screen for skin cancer, such as melanoma.

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

Public Release: 26-Jul-2016
eLife
To divide or not: a cellular feedback loop enables new cells to make a fateful decision
New research sheds light on a critical decision every newly born cell makes: whether to continue to proliferate or exit the cell-division cycle. In cancer, the equivalent of an 'on' switch is stuck in that position. In healthy cells, the team has discovered, the opposing effects of proteins ORC1 and CDC6 in controlling the level of Cyclin E contributes to the stability of the genome.
NIH/National Cancer Institute

Contact: Peter Tarr
tarr@cshl.edu
516-367-5055
Cold Spring Harbor Laboratory

Public Release: 26-Jul-2016
Nucleic Acids Research
Genome-editing 'toolbox' targets multiple genes at once
A Yale research team has designed a system to modify, or edit, multiple genes in the genome simultaneously, while also minimizing unintended effects. The gene-editing 'toolbox' provides a user-friendly solution that scientists can apply to research on cancer and other disciplines, the researchers said.
American Cancer Society, US Department of Defense Breast Cancer Research Program, National Institutes of Health

Contact: Bill Hathaway
william.hathaway@yale.edu
203-432-1322
Yale University

Public Release: 26-Jul-2016
JAMA
Stereotactic radiosurgery may be best for patients with metastatic brain tumors
Patients with three or fewer metastatic brain tumors who received treatment with stereotactic radiosurgery had less cognitive deterioration three months after treatment than patients who received SRS combined with whole brain radiation therapy. These findings are according to the results of a federally funded, Mayo Clinic-led, multi-institution research study published today in the Journal of the American Medical Association.

Contact: Joe Dangor
newsbureau@mayo.edu
507-284-5005
Mayo Clinic

Public Release: 26-Jul-2016
Environmental International
Study links gymnastics equipment to exposure to flame-retardant chemicals
As the summer Olympics get underway, a new study co-authored by Boston University School of Public Health researchers reports that popular gymnastics training equipment contains mixtures of flame-retardant chemicals that have been linked to increased risks of ADHD, cancer and brain development delays.

Contact: Lisa Chedekel
chedekel@bu.edu
617-571-6370
Boston University Medical Center

Public Release: 25-Jul-2016
Proceedings of the National Academy of Sciences
Scientists test nanoparticle drug delivery in dogs with osteosarcoma
An engineer teamed up with a veterinarian to test a bone cancer drug delivery system in animals bigger than the standard animal model, the mouse. They chose dogs -- mammals closer in size and biology to humans -- with naturally occurring bone cancers, which also are a lot like human bone tumors. The researchers report their results in the Proceedings of the National Academy of Sciences.
Morris Animal Foundation, National Institutes of Health, National Cancer Institute Alliance for Nanotechnologyin Cancer

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign

Public Release: 25-Jul-2016
Journal of Clinical Investigation
BRCA1 mutations in breast and ovarian cancer can predict treatment resistance
This month, two studies in the JCI investigated the mechanisms underlying the treatment resistance associated with some BRCA1 mutations, and the findings provide information that may help predict which treatments will be effective in women with breast and ovarian cancer.
Dutch Cancer Society, Netherlands Organization for Scientific Research, European Union Seventh Framework Programme, European Research Council, Howard Hughes Medical Institute, NIH/National Cancer Institute

Contact: Elyse Dankoski
press_releases@the-jci.org
JCI Journals

Public Release: 25-Jul-2016
Nature Materials
Patch delivers drug, gene, and light-based therapy to tumor sites
A research team led by Natalie Artzi of MIT and Brigham and Women's hospital delivers drug, gene, and light-based therapy directly to tumor sites, with promising results.

Contact: Karl-Lydie Jean-Baptiste
kjeanbap@mit.edu
617-253-1682
Massachusetts Institute of Technology

Public Release: 25-Jul-2016
Cancer
Delirium in advanced cancer patients often goes undetected in the emergency department
A new study indicates that delirium is relatively frequent and underdiagnosed by physicians in patients with advanced cancer visiting the emergency department. Delirium was similarly common among older and younger patients, which suggests that in the setting of advanced cancer, all patients should be considered at higher risk for delirium. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society.

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley

Public Release: 25-Jul-2016
Lancet Oncology
Novel statistical method captures long-term health burden of pediatric cancer cures
St. Jude Children's Research Hospital researchers have developed a metric that showed therapy-related cardiovascular disease takes a heavier toll on pediatric Hodgkin lymphoma survivors than previously recognized.
NIH/National Cancer Institute, St. Baldrick's Foundation, American Lebanese Syrian Associated Charities

Contact: Jann Ingmire
Jann.Ingmire@STJUDE.ORG
901-595-6384
St. Jude Children's Research Hospital

Public Release: 25-Jul-2016
Proceedings of the National Academy of Sciences
WSU researchers get unprecedented look at DNA damage
Washington State University researchers have mapped the damage of ultraviolet radiation on individual units of DNA, opening a new avenue in the search for how sunlight causes skin cancer and what might be done to prevent it. 'This technique gives you almost a satellite-view image of all the damage across the genome,' said John Wyrick, a WSU geneticist specializing in DNA repair.
NIH/National Institute of Environmental Health Sciences, Breast Cancer Research Program Breakthrough Award from the Department of Defense

Contact: John Wyrick
jwyrick@wsu.edu
509-335-8785
Washington State University

Public Release: 25-Jul-2016
Breast Cancer Research
Rat fathers' diets may affect offspring's breast cancer risk
The dietary habits of rat fathers may affect their daughters' breast cancer risk, a study in 60 male rats and their offspring has found. The study is published in the open access journal Breast Cancer Research. Researchers at the University of Sao Paulo showed that the female offspring of male rats which had been fed a diet rich in animal fats had an increased risk of breast cancer. A diet that was rich in vegetable fats reduced the offspring's risk of breast cancer.

Contact: Anne Korn
anne.korn@biomedcentral.com
44-020-319-22744
BioMed Central

Public Release: 25-Jul-2016
Journal of Urology
Patients with low risk prostate cancer on active surveillance experience good quality of life
Active surveillance (AS) has become an increasingly important alternative to surgery, chemotherapy, or radiation treatment for men diagnosed with low risk prostate cancer. However, what is the impact of AS on health-related quality of life (HRQoL) in patients selected or opting for this conservative form of disease management? New research published in the Journal of Urology® found that patients on AS who were tracked for three years experienced similar HRQoL as men without prostate cancer, both clinically and psychologically.

Contact: Eileen Leahy
jumedia@elsevier.com
732-238-3628
Elsevier Health Sciences

Public Release: 25-Jul-2016
Pharmacogenomics
Transcriptome differences in prostate cancer highlight racial disparities and vitamin D
Investigators at the Medical University of South Carolina and Ralph H. Johnson VA Medical Center report clinical research showing that African-American and European-American men with prostate cancer exhibit significantly different expression of genes associated with immune response and inflammation, in the July 2016 issue of Pharmacogenomics. Systems-level, RNA analyses support the concept that inflammatory processes may contribute to racial disparities in disease progression and that vitamin D3 supplementation can modulate pro-inflammatory transcripts.
Supported by Genomics Shared Resource, Hollings Cancer Center, Medical University of South Carolina

Contact: Heather Woolwine
woolwinh@musc.edu
843-792-7669
Medical University of South Carolina

Public Release: 25-Jul-2016
Journal of Pain Research
Effectiveness of the WHO cancer pain relief guidelines published by Dove Medical Press
The WHO guidelines have been successful in making pain relief knowledge more available, but from a moral and ethical standpoint these guidelines need to be promoted and examined until adequate pain relief is reported in all possible cancer pain patients.

Contact: Angela Jones
angela@dovepress.com
Dove Medical Press

Public Release: 25-Jul-2016
BMC Health Services Research
Texans are no better off in one city versus another for cancer treatment
Regions in Texas differ widely in adherence to recommended cancer treatment for elderly patients, according to a study by researchers at Rice University and the University of Texas MD Anderson Cancer Center. These differences are not due to the availability of treatment specialists or the presence of teaching hospitals, the study found. The absence of consistent explanations for these treatment differences suggests that variations like these are likely to occur elsewhere nationwide.
Cancer Prevention Research in Texas

Contact: Jeff Falk
jfalk@rice.edu
713-348-6775
Rice University

Public Release: 25-Jul-2016
Journal of Thoracic Oncology
Liquid biopsies for identification of EGFR mutations and prediction of recurrence
Three manuscripts published in the recent issue of the Journal of Thoracic Oncology explored the versatility of liquid biopsies by identifying EGFR mutations using circulating tumor DNA in urine and plasma and examining circulating tumor cells in plasma to predict the risk of lung cancer recurrence after surgical resection. Collectively, these findings illustrate the potential and reach of liquid biopsies in both identifying patients suitable for targeted treatment as well as predicting cancer recurrence.

Contact: Jeff Wolf
Jeff.Wolf@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Public Release: 25-Jul-2016
Nature Communications
Salmonella protein reduces drug resistance in tumors
A surprising result in an experiment on Salmonella bacteria has led to a discovery that may make drug resistant cancer cells more treatable by conventional chemotherapies. Scientists at the University of Massachusetts Medical School have found that the Salmonella protein SipA naturally reduces a well-known drug-resistant molecule found in many different types of cancer cells.

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2688
University of Massachusetts Medical School

Public Release: 25-Jul-2016
Cancer Research
Tel Aviv University research opens the 'black box' of malignant melanoma
A new Tel Aviv University study pinpoints when melanoma cells metastasize in the brain months before they develop into fatal tumors.

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University

Public Release: 25-Jul-2016
Proceedings of the National Academy of Sciences
Hot news flash! Menopause, insomnia accelerate aging
Two separate UCLA studies reveal that menopause -- and the insomnia that often accompanies it -- make women age faster. The dual findings suggest these factors could increase women's risk for aging-related diseases and earlier death.
NIH/National Heart, Lung, and Blood Institute, NIH/National Institute of Aging, NIH/National Institute on Drug Abuse, UCLA Cousins Center for Psychoneuroimmunology

Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-597-5767
University of California - Los Angeles Health Sciences

Public Release: 23-Jul-2016
Cell
Quantitating the complete human proteome
Institute for Systems Biology scientists collaborate with ETH Zurich to develop the Human SRMAtlas, a compendium of mass spectrometry assays for any human protein. ISB releases protein assay parameters freely to the scientific community for the ability to assay any human protein without restriction. Through the use of the ISB Human SRMAtlas, biomarker candidates, wellness markers and protein networks can be quickly evaluated to provide quantitative results on disease, wellness and biological processes.
National Institutes of Health, European Research Council

Contact: Hsiao-Ching Chou
hchou@systemsbiology.org
206-732-2157
Institute for Systems Biology

Showing releases 201-225 out of 1382.

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