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Showing releases 201-225 out of 1412.

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Public Release: 1-Jul-2016
New method provides better information on gene expression
Scientists at Karolinska Institutet and the Royal Institute of Technology (KTH) in Sweden have devised a new high-resolution method for studying which genes are active in a tissue. The method can be used on all types of tissue and is valuable to both preclinical research and cancer diagnostics. The results are published in the journal Science.
Knut and Alice Wallenberg Foundation, Swedish Foundation for Strategic Research, Swedish Research Council, Swedish Society, Karolinska Institutet, Tobias Foundation, Torsten Söderberg

Contact: KI Press Office
Karolinska Institutet

Public Release: 1-Jul-2016
Cancer Research
New anti-cancer strategy mobilizes both innate and adaptive immune response
Scientists from the RIKEN Center for Integrative Medical Sciences have developed a new vaccine that involves injecting cells that have been modified so that they can stimulate both an innate immune response and the more specific adaptive response, which allows the body to keep memories and attack new tumor cells as they form.

Contact: Jens Wilkinson

Public Release: 1-Jul-2016
Cancer Epidemiology, Biomarkers & Prevention
Aging population is growing ranks of cancer survivors
Improved cancer detection and treatment efforts, combined with demographic trends, are creating larger numbers of older cancer survivors who are likely to have other health conditions that impact care and well-being.
NIH/National Cancer Institute

Contact: Lauren Riley
American Association for Cancer Research

Public Release: 1-Jul-2016
Science Advances
E. coli: The ideal transport for next-gen vaccines?
Researchers have developed an E. coli-based transport capsule to help next-generation vaccines do a more efficient and effective job than today's immunizations. The research, described in a study published July 1 in the journal Science Advances, highlights the capsule's success fighting pneumococcal disease, an infection that can result in pneumonia, sepsis, ear infections and meningitis.
National Institutes of Health, University at Buffalo/Arthur A. Schomburg Fellowship Program

Contact: Cory Nealon
University at Buffalo

Public Release: 30-Jun-2016
Cell Reports
Gene mutation 'hotspots' linked to better breast cancer outcomes
Using a database of human tumor genomic data, researchers at the University of California San Diego, School of Medicine and Moores Cancer Center discovered that mutation hotspots known as kataegis are a positive marker in breast cancer -- patients with kataegis have less invasive tumors and better prognoses. The study, published June 30 in Cell Reports, also suggests kataegis status could help doctors determine treatment options that might work best for patients with the mutation pattern.
National Institutes of Health

Contact: Heather Buschman
University of California - San Diego

Public Release: 30-Jun-2016
Researchers identify calorie-burning pathway in fat cells
Investigators at Dana-Farber Cancer Institute have identified a natural molecular pathway that enables cells to burn off calories as heat rather than store them as fat. This raises the possibility of a new approach to treating and preventing obesity, diabetes, and other obesity-linked metabolic disorders including cancer.
National Institutes of Health

Contact: Anne Doerr
Dana-Farber Cancer Institute

Public Release: 30-Jun-2016
Cell Reports
Study finds potential treatment for non-alcoholic fatty liver disease
Researchers report in the journal Cell Reports a targeted molecular therapy that dramatically reduces the initial development of non-alcoholic fatty liver disease (NAFLD) in laboratory mouse models of the disease. The study, published online June 30, found increased levels of an enzyme called cdk4 in patients with NAFLD and in mouse models. Using two drugs that inhibit cdk4 in mouse models reduced development of hepatic steatosis -- the first stage of the disease.

Contact: Nick Miller
Cincinnati Children's Hospital Medical Center

Public Release: 30-Jun-2016
BJU International
Certain occupations linked to increased bladder cancer risk
A new analysis of UK workers reveals that certain occupations may increase the risk of bladder cancer.

Contact: Penny Smith

Public Release: 30-Jun-2016
Journal of the American College of Surgeons
Incidence of cancer in patients with large colorectal polyps lower than previously thought
For the majority of patients with large or difficult to remove colorectal polyps (growths in the colon), the incidence of cancer is actually lower than previously thought, and using more advanced endoscopic techniques that spare the colon may be a better, safer alternative to a traditional operation in certain cases, according to study results published online in the Journal of the American College of Surgeons in advance of print publication.

Contact: Sally Garneski
American College of Surgeons

Public Release: 30-Jun-2016
JAMA Oncology
BRCA1 mutations linked to increased risk of serous, serous-like endometrial cancer
Increased risk for aggressive serous/serous-like endometrial cancer was increased in women with BRCA1 mutations, although the overall risk for uterine cancer after risk-reducing salpingo-oophorectomy (RRSO) to remove the fallopian tube and ovary was not increased, according to a new study published online by JAMA Oncology.

Contact: Sarah Avery
The JAMA Network Journals

Public Release: 30-Jun-2016
ESMO World Congress on Gastrointestinal Cancer 2016
Annals of Oncology
Chemoradiotherapy after surgery for GC shows similar outcomes to post-operative chemotherapy
Post-operative treatment intensification with chemoradiotherapy does not achieve better outcomes when compared to post-operative chemotherapy in patients with gastric cancer who have already undergone pre-operative chemotherapy, according to phase III data presented at the ESMO 18th World Congress of Gastrointestinal Cancer in Barcelona, Spain.

Contact: ESMO Press Office
European Society for Medical Oncology

Public Release: 30-Jun-2016
Scientific Reports
New technology helps ID aggressive early breast cancer
Researchers at the University of Michigan developed a new technology that can identify aggressive forms of ductal carcinoma in situ, or stage 0 breast cancer, from non-aggressive varieties.
Mildred E. Swanson Foundation, National Institutes of Health

Contact: Nicole Fawcett
University of Michigan Health System

Public Release: 30-Jun-2016
Journal of Clinical Nursing
Cervical cancer screening among lesbian and bisexual women and transgender men
A new study found that certain factors affect cervical cancer screening among lesbian and bisexual women and transgender men. Some of these factors overlap with the general female population, whereas others are specific to the lesbian, bisexual, or queer identity.

Contact: Penny Smith

Public Release: 30-Jun-2016
Journal of Clinical Oncology
Telomere length is indicator of blood count recovery in treatment of Acute Myeloid Leukemia
The chemotherapy treatments necessary to treat Acute Myeloid Leukemia (AML) in children can be grueling on the body, and can cause health-related complications during therapy, as well as long down the road after remission. Children receiving chemotherapy for AML receive 4 to 5 intensive chemotherapy courses, and while some children recover quickly from each course, others may take several months or more, which increases their risk for life-threatening infections.
Alex's Lemonade Stand Young Investigators Award, St. Baldrick's Foundation Scholar Award, National Institutes of Health

Contact: Allison Huseman
Baylor College of Medicine

Public Release: 30-Jun-2016
The Journal of Biological Chemistry
Treating diseases at their origin
Hokkaido University scientists are getting closer to understanding the function of a protein involved in vital cellular processes. This may lead to the discovery of drugs that can treat some cancers and autoimmune disorders.
The Ministry of Education, Culture, Sports, Science and Technology of Japan

Contact: Naoki NAMBA (Media Officer)
Hokkaido University

Public Release: 30-Jun-2016
JAMA Oncology
Women with BRCA1 gene mutation at higher risk of deadly uterine cancer
Women who carry the BRCA1 gene mutation that dramatically increases their risk of breast and ovarian cancers are also at higher risk for a lethal form of uterine cancer, according to a study led by a Duke Cancer Institute researcher.
US Department of Defense, National Institutes of Health, NIH/National Cancer Institute

Contact: Sarah Avery
Duke University Medical Center

Public Release: 30-Jun-2016
ESMO World Congress on Gastrointestinal Cancer 2016
Annals of Oncology
Regorafenib shows significant survival gains in refractory liver cancer
Oral multikinase inhibitor regorafenib achieves significantly improved survival rates compared to placebo in patients with hepatocellular carcinoma, according to data from the phase III RESORCE trial, presented at the ESMO 18th World Congress of Gastrointestinal Cancer in Barcelona, Spain.

Contact: ESMO Press Office
European Society for Medical Oncology

Public Release: 30-Jun-2016
Women at risk of ovarian cancer need more guidance from doctors on their choices
Researchers at Cardiff University have found that online information about ovarian cancer can cause as much worry as comfort for women at high risk of developing the disease, in a new study published in ecancer. For women at an increased risk of ovarian cancer but who haven't yet developed the disease, the most effective way to manage their risk is to surgically remove their fallopian tubes and ovaries.

Contact: Katie Foxall

Public Release: 29-Jun-2016
Protein associated with improved survival in some breast cancer patients
A family of proteins that help cancer cells survive and spread around the body may be associated with improved prognosis for some women receiving treatment for breast cancer, research has shown.
Breast Cancer Now

Contact: Emma Thorne
University of Nottingham

Public Release: 29-Jun-2016
ESMO World Congress on Gastrointestinal Cancer 2016
Annals of Oncology
Anti-PD-L1 immunotherapy responsive in microsatellite-stable mCRC comb with MEK inhibition
Anti-PD-L1 immunotherapy may achieve a response in patients with microsatellite-stable metastatic colorectal cancer if combined with a MEK inhibitor, according to phase I data presented at the ESMO 18th World Congress of Gastrointestinal Cancer in Barcelona, Spain.

Contact: ESMO Press Office
European Society for Medical Oncology

Public Release: 29-Jun-2016
American Journal of Roentgenology
AJR opinion piece considers managing the radiation dose while communicating the risk
Despite evidence that low doses of ionizing radiation associated with imaging are not dangerous, the medical community is frequently faced with the challenge of communicating the risk and managing the dose.

Contact: Kimberly Coghill
American Roentgen Ray Society

Public Release: 29-Jun-2016
ACS Nano
How cancer cells spread and squeeze through tiny blood vessels (video)
The spread of cancer from a tumor's original location to other parts of the body can play a major role in whether the disease turns deadly. Many steps in this process, called metastasis, remain murky. But now scientists are gaining new insights into how cancer cells might squeeze through and even divide within narrow blood vessels while traveling in the body. They report their study using microtubular nanomembranes in the journal ACS Nano.

Contact: Michael Bernstein
American Chemical Society

Public Release: 29-Jun-2016
Cancer Research
New technique sorts drivers from passengers in cancer genomics, implicates GON4L
A University of Colorado Cancer Center study published in the journal Cancer Research demonstrates a novel method for sorting passenger from driver alterations, and uses this method to pinpoint a new driver and potential therapeutic target in cancer progression, GON4L.

Contact: Erika Matich
University of Colorado Anschutz Medical Campus

Public Release: 29-Jun-2016
New method detects telomere length for research into cancer, aging
UT Southwestern Medical Center cell biologists have identified a new method for determining the length of telomeres, the endcaps of chromosomes, which can influence cancer progression and aging.

Contact: Lori Sundeen Soderbergh
UT Southwestern Medical Center

Public Release: 29-Jun-2016
Lancet Haematology
Everolimus R-CHOP combination safe for treating diffuse large B-cell lymphoma
The targeted therapy everolimus may be safely combined with R-CHOP for new, untreated diffuse large B-cell lymphoma according to the results of a pilot study by Mayo Clinic researchers published in the Lancet Haematology. R-CHOP is a combination of drugs used to treat lymphoma. The combination includes rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone.

Contact: Joe Dangor
Mayo Clinic

Showing releases 201-225 out of 1412.

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