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Showing releases 201-225 out of 1284.

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Public Release: 23-Jun-2014
Cancer
Family dysfunction a strong predictor of emotional problems in children of cancer patients
A cancer diagnosis affects the whole family, and a significant number of children of cancer patients may be at risk for emotional and behavioral problems.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
Wiley

Public Release: 23-Jun-2014
Nature Genetics
New study offers potential avenues for treatment of deadly nasopharyngeal cancer
A team of scientists from the Cancer Science Institute of Singapore at the National University of Singapore, National University Cancer Institute Singapore and National University Hospital Singapore, discovered a distinct mutational signature and nine significantly mutated genes associated with nasopharyngeal cancer, paving the way to developing novel therapies for this deadly disease.

Contact: Kimberley Wang
kimberley.wang@nus.edu.sg
65-660-11653
National University of Singapore

Public Release: 23-Jun-2014
ICE/ENDO 2014
BPA stimulates growth of breast cancer cells, diminishes effect of treatment
Bisphenol A, a chemical commonly used in plastics, appears to increase the proliferation of breast cancer cells, according to Duke Medicine researchers presenting at an annual meeting of endocrine scientists.
NIH/National Cancer Institute, Duke/Department of Surgery D.P. Bolognesi Award, Duke Cancer Institute, American Cancer Society

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

Public Release: 23-Jun-2014
PLOS ONE
Study sheds light on racial disparity in colon cancer
African-Americans with colon cancer are half as likely as Caucasian patients to have a type of colon cancer that is linked to better outcomes. The finding may provide insight into why African-Americans are more likely to die of colon cancer than Caucasians with the same stage of disease.
National Institutes of Health

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 23-Jun-2014
Journal of Biological Chemistry
SLU researchers see possible answer to chemo pain in a multiple sclerosis drug
Saint Louis University researchers describe two discoveries: a molecular pathway by which a painful chemotherapy side effect happens and a drug that may be able to stop it.
Leukemia and Lymphoma Society, Mayday Fund, Saint Louis University Cancer Center

Contact: Carrie Bebermeyer
bebermcl@slu.edu
314-977-8015
Saint Louis University

Public Release: 23-Jun-2014
Nature
Cancer genes hijack enhancers
Unlike most other forms of cancer, medulloblastomas exhibits very few mutations in growth-promoting genes. In collaboration with an international team of colleagues, scientists from the German Cancer Research Center have now made an important discovery about a particularly malignant subgroup of medulloblastomas: often the cancer-causing genes are transcribed at higher or lower levels than normal. This change is due to regulatory mechanisms that were previously unknown. For example, one cancer-gene hijacks a so-called 'enhancer.'
German Cancer Aid, German Federal Ministry of Education and Research

Contact: Dr. Sibylle Kohlstädt
s.kohlstaedt@dkfz.de
German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)

Public Release: 23-Jun-2014
Annals of Internal Medicine
Annals of Internal Medicine tip sheet for June 24, 2014
The June 24, 2014, Annals of Internal Medicine contains papers titled: 'Task Force recommends one-time screening for abdominal aortic aneurysms in older male smokers' and 'Caution advised before implementing widespread lung cancer screening among Medicare beneficiaries.'

Contact: Megan Hanks
mhanks@acponline.org
215-351-2656
American College of Physicians

Public Release: 23-Jun-2014
Journal of Men's Health
Is focal treatment for prostate cancer as effective in the long-term as radical therapies?
Focal therapy for prostate cancer, in which only the tumor tissue is treated with cryoablation (freezing), can prolong life, result in less complications such as incontinence, and improve post-treatment quality of life. But the long-term effectiveness of focal treatments has not been well-studied. A new analysis that followed patients treated with optimized cryoablation of prostate cancer for an average of 10 years post-treatment is published in Journal of Men's Health.

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 23-Jun-2014
Cell Reports
Long non-coding RNAs can encode proteins after all
Case Western Reserve School of Medicine scientists have made an extraordinary double discovery. First, they have identified thousands of novel long non-coding ribonucleic acid transcripts. Second, they have learned that some of them defy conventional wisdom regarding lncRNA transcripts, because they actually do direct the synthesis of proteins in cells. Both of the breakthroughs are detailed in the June 12 issue of Cell Reports.
NIH, National Science Foundation

Contact: Jeannette Spalding
jeannette.spalding@case.edu
216-368-3004
Case Western Reserve University

Public Release: 23-Jun-2014
Nature Cell Biology
The colon has a safety mechanism that restricts tumor formation
Colon cancer development starts with the formation of benign tumors called adenomas. It is estimated that between 30 and 50 percent of people over 50 will develop one of these tumors. These adenomas or polyps are pre-cancerous lesions that over many years, can progress to colon cancer. Scientists at the IRB Barcelona have discovered that the colon has a safety mechanism to restrict the formation and growth of adenomas. The study was published on Sunday in Nature Cell Biology.
European Research Council, Spanish Ministry of Economy and Competitiviness, Josef Steiner Foundation

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)

Public Release: 23-Jun-2014
Pediatrics
Young indoor tanning increases early risk of skin cancer
Dartmouth researchers have found that early exposure to the ultraviolet radiation lamps used for indoor tanning is related to an increased risk of developing basal cell carcinomas at a young age. Their findings are reported in the July 2014 issue of Pediatrics. Since indoor tanning has become increasingly popular among adolescents and young adults, this research calls attention to the importance of counseling young people about the risk of indoor tanning.
National Institutes of Health, NIH/National Cancer Institute, NIH/National Institute for Environmental Health, US Environmental Protection Agency

Contact: Robin Dutcher
Robin.Dutcher@hitchcock.org
603-653-9056
The Geisel School of Medicine at Dartmouth

Public Release: 23-Jun-2014
Endocrine Society Annual Meeting
Anti-androgen therapy for triple-negative breast cancer may benefit lower-androgen tumors
A new University of Colorado Cancer Center study being presented today at the Endocrine Society Annual Meeting shows that even triple negative breast cancers expressing very low levels of androgen receptor may benefit from this therapy.

Contact: Erika Matich
erika.matich@ucdenver.edu
University of Colorado Denver

Public Release: 23-Jun-2014
Proceedings of the National Academy of Sciences
Delivering drugs on cue
Current drug-delivery systems used to administer chemotherapy to cancer patients typically release a constant dose of the drug over time -- but a new study challenges this 'slow and steady' approach and offers a novel way to locally deliver the drugs 'on demand,' as reported in the Proceedings of the National Academy of Sciences.
Harvard University, NIH/National Institute of Dental and Craniofacial Research, California Institute for Regenerative Medicine

Contact: Kristen Kusek
kristen.kusek@wyss.harvard.edu
617-432-8266
Wyss Institute for Biologically Inspired Engineering at Harvard

Public Release: 22-Jun-2014
Nature
Cancer by remote-control
One of the deadliest forms of paediatric brain tumour, Group 3 medulloblastoma, is linked to a variety of large-scale DNA rearrangements which all have the same overall effect on specific genes located on different chromosomes. The finding, by scientists at EMBL Heidelberg and collaborators, is published online today in Nature.
German Cancer Aid, German Federal Ministry of Education and Research

Contact: Sonia Furtado Neves
sonia.furtado@embl.de
European Molecular Biology Laboratory

Public Release: 22-Jun-2014
Nature
Microenvironment of hematopoietic stem cells can be a target for myeloproliferative disorders
The protective microenvironment of the hematopoietic stem cell niche, which produces cells of the blood and the immune system, also protects against myeloproliferative neoplasia.

Contact: AInhoa Iriberri
airiberri@cnic.es
34-610-295-556
Centro Nacional de Investigaciones Cardiovasculares

Public Release: 22-Jun-2014
Nature
Researchers discover new genes that promote brain cancer
Study identifies two novel oncogenes that cause childhood brain cancer when activated.

Contact: Susan Gammon, Ph.D.
sgammon@sanfordburnham.org
858-795-5012
Sanford-Burnham Medical Research Institute

Public Release: 22-Jun-2014
ICE/ENDO 2014
Growth hormone defect may protect against diabetes, cancer in unique ecuador population
People who lack growth hormone receptors also appear to have marked insulin sensitivity that prevents them from developing diabetes and lowers their risk for cancer, despite their increased percentage of body fat, new research finds. The results were presented Sunday, June 22, at ICE/ENDO 2014, the joint meeting of the International Society of Endocrinology and the Endocrine Society in Chicago.
The Instituto de Endocrinologia Metabolismo y Reproducción

Contact: Aaron Lohr
alohr@endocrine.org
202-971-3654
The Endocrine Society

Public Release: 22-Jun-2014
ICE/ENDO 2014
BPA exposure during fetal development raises risk of precancerous prostate lesions
A new study has found for the first time that the endocrine-disrupting chemical bisphenol A, BPA, reprograms the developing prostate, making the gland more susceptible to precancerous lesions and other diseases later in a man's life. The results will be reported Sunday at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago.

Contact: Aaron Lohr
alohr@endocrine.org
202-971-3654
The Endocrine Society

Public Release: 21-Jun-2014
ICE/ENDO 2014
Possible new weapon found for fighting some types of breast cancer
Researchers believe they have discovered one reason why some women with estrogen receptor-positive breast cancer may respond poorly or only temporarily to estrogen-blocking drugs such as tamoxifen. Results of a new study, which was presented Saturday at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago, point to a previously unrecognized role of the androgen receptor.

Contact: Aaron Lohr
alohr@endocrine.org
202-971-3654
The Endocrine Society

Public Release: 20-Jun-2014
Cancer
For cancer patients, new tool predicts financial pain
Cancer care has a new side effect. Patients now have to deal with 'financial toxicity,' the expense, anxiety and loss of confidence confronting those who face large, unpredictable costs, often compounded by decreased ability to work. A team of cancer specialists describe COST, the first tool to measure a patient's risk for, and ability to tolerate, financial stress.
National Institutes of Health

Contact: John Easton
John.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center

Public Release: 20-Jun-2014
Cancer Causes & Control
Menthol cigarettes linked to increased smoking among teens
Teens who use menthol cigarettes smoke more cigarettes per day than their peers who smoke non-menthols, says a new study. The findings from the Propel Centre for Population Health Impact at the University of Waterloo mark the first time that menthol cigarettes have been directly linked to elevated nicotine addiction among youth in Canada.
Canadian Cancer Society

Contact: Pamela Smyth
psmyth@uwaterloo.ca
519-888-4777
University of Waterloo

Public Release: 20-Jun-2014
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
Festschrift issue for Hilary Koprowski, MD
The June issue of Monoclonal Antibodies in Immunodiagnosis and Immunotherapy is a special tribute issue for Hilary Koprowski, MD (1916-2013).

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 19-Jun-2014
JAMA
Drug shows promise for the first time against metastatic melanoma of the eye
For the first time, a therapy has been found that can delay progression of metastatic uveal melanoma, a rare and deadly form of melanoma of the eye.
NIH/National Cancer Institute

Contact: Karin Eskenazi
Ket2116@columbia.edu
Columbia University Medical Center

Public Release: 19-Jun-2014
Optics Letters
A better imager for identifying tumors
Researchers have developed a new technique that could improve surgeons' ability to identify cancerous tumors and remove them in real-time in the operating room. The new imaging system combines two techniques -- near-IR fluorescent imaging and visible light reflectance imaging -- to get a much better picture of the tissue. The work, from the University of Arizona and Washington University in St. Louis, was published in the journal Optics Letters today.

Contact: Lyndsay Meyer
lmeyer@osa.org
202-416-1435
The Optical Society

Public Release: 19-Jun-2014
Cell Reports
A new tool to confront lung cancer
Published online in Cell Reports on June 19, Huntsman Cancer Institute investigators report that misregulation of two genes, sox2 and lkb1, drives squamous cell lung cancer in mice. The discovery uncovers new treatment strategies, and provides a clinically relevant mouse model in which to test them.
US Department of Defense, V Foundation for Cancer Research, Damon Runyon Cancer Research Foundation

Contact: Linda Aagard
Linda.Aagard@hci.utah.edu
801-587-7639
University of Utah Health Sciences

Showing releases 201-225 out of 1284.

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