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Showing releases 201-225 out of 1363.

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Public Release: 3-Jul-2015
ESMO 17th World Congress on Gastrointestinal Cancer
Annals of Oncology
Studies confirm regorafenib benefit in pre-treated metastatic colorectal cancer
The phase IIIb CONSIGN study has confirmed the benefit of regorafenib in patients with previously treated metastatic colorectal cancer (mCRC), researchers announced at the ESMO 17th World Congress on Gastrointestinal Cancer 2015 in Barcelona. The safety profile and progression free survival were similar to phase III trial results.

Contact: ESMO Press Office
media@esmo.org
European Society for Medical Oncology

Public Release: 2-Jul-2015
European Heart Journal
Experts call for 'all hands on deck' to tackle global burden of non-communicable disease
A group of the world's top doctors and scientists working in cardiology and preventive medicine have issued a call to action to tackle the global problem of deaths from non-communicable diseases, such as heart problems, diabetes and cancer, through healthy lifestyle initiatives. Their suggestions to prevent or delay health conditions that cause the deaths of over 36 million people worldwide each year are published simultaneously in Mayo Clinic Proceedings and the European Heart Journal.

Contact: Emma Mason
wordmason@mac.com
European Society of Cardiology

Public Release: 2-Jul-2015
Molecular Cell
Melanoma mutation rewires cell metabolism
A mutation found in most melanomas rewires cancer cells' metabolism, making them dependent on a ketogenesis enzyme. The finding points to possible strategies for countering resistance to existing drugs that target the B-raf V600E mutation, or potential alternatives to those drugs. It may also explain why the V600E mutation in particular is so common in melanomas.
NIH/National Cancer Institute, American Cancer Society, Leukemia and Lymphoma Society

Contact: Judy Fortin
judy.fortin@emory.edu
404-778-4580
Emory Health Sciences

Public Release: 2-Jul-2015
Developmental Cell
Hippo dances with hormones
In fruit flies, the abnormal growth induced by Hippo pathway disruption depends on genes involved in responding to the steroid hormone ecdysone. This has potential implications for human biology, since the Hippo pathway is involved in suppressing cancer growth and forming embryonic stem cells.
NIH/National Institute of General Medical Sciences, NIH/National Cancer Institute

Contact: Quinn Eastman
qeastma@emory.edu
404-727-7829
Emory Health Sciences

Public Release: 2-Jul-2015
Nature Communications
Scientists advance cancer drug design with image of 1 of key proteins of life
Scientists have pioneered the use of a high-powered imaging technique to picture in exquisite detail one of the central proteins of life -- a cellular recycling unit with a role in many diseases.
Cancer Research UK, Medical Research Council

Contact: Henry French
henry.french@icr.ac.uk
020-715-35582
Institute of Cancer Research

Public Release: 2-Jul-2015
Cell Stem Cell
New measurements reveal differences between stem cells for treating retinal degeneration
By growing two types of stem cells in a '3-D culture' and measuring their ability to produce retinal cells, a team lead by St. Jude Children's Research Hospital researchers has found one cell type to be better at producing retinal cells.
National Institutes of Health, Howard Hughes Medical Institute, Alex's Lemonade Stand Foundation for Childhood Cancer and ALSAC

Contact: Frannie Marmorstein
frannie.marmorstein@stjude.org
901-379-6072
St. Jude Children's Research Hospital

Public Release: 2-Jul-2015
Psycho-Oncology
Cancer survivors who smoke perceive less risk from tobacco
Cancer survivors who smoke report fewer negative opinions about smoking, have more barriers to quitting, and are around other smokers more often than survivors who had quit before or after their diagnosis.
American Cancer Society

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society

Public Release: 1-Jul-2015
ESMO 17th World Congress on Gastrointestinal Cancer
Annals of Oncology
Evaluation of NK1 antagonists for emesis prevention in oxaliplatin chemo: SENRI trial
The SENRI trial has opened the window to evaluate NK1 antagonists for emesis prevention in patients taking oxaliplatin chemotherapy, results of a Japanese study presented today at the ESMO 17th World Congress on Gastrointestinal Cancer 2015 in Barcelona reveal.

Contact: ESMO Press Office
media@esmo.org
European Society for Medical Oncology

Public Release: 1-Jul-2015
Nature Communications
How removing a protein slows blood vessel growth in tumors
Scientists from the University of Leeds and The Institute of Cancer Research, London, have discovered a new protein which triggers the growth of blood vessels in breast cancer tumors which have spread to the brain, a common location which breast cancer can spread to.

Contact: Ben Jones
B.P.Jones@leeds.ac.uk
44-011-334-38059
University of Leeds

Public Release: 1-Jul-2015
The EMBO Journal
Live imaging reveals how wound healing influences cancer
Researchers in the United Kingdom and Denmark have studied the 'see-through' larvae of zebrafish to reveal how wound healing leads to melanoma.

Contact: Barry Whyte
barry.whyte@embo.org
EMBO

Public Release: 1-Jul-2015
Neuro-Oncology: Clinical Practice
Improved survival in adult patients with low-grade brain tumors
Using clinical data collected over the past decade through a US cancer registry, researchers at the University of California, San Diego School of Medicine demonstrated that significant strides have been made in improving the survival of adult patients with low-grade gliomas, a slow-growing yet deadly form of primary brain cancer.
Sontag Foundation, Burroughs Wellcome Foundation, Kimmel Foundation, Doris Duke Foundation, Forbeck Foundation

Contact: Jackie Carr
jcarr@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 1-Jul-2015
ESMO 17th World Congress on Gastrointestinal Cancer
Annals of Oncology
Patients with lowest BMI have shortest survival in pooled analysis of bev in mCRC
Patients with the lowest body mass index had the shortest overall survival in an analysis of bevacizumab studies in metastatic colorectal cancer presented for the first time at the ESMO 17th World Congress on Gastrointestinal Cancer 2015 in Barcelona.

Contact: ESMO Press Office
media@esmo.org
European Society for Medical Oncology

Public Release: 1-Jul-2015
International Journal of Radiation Oncology, Biology and Physics
Many patients with advanced form of larynx cancer not receiving recommended treatment
Despite findings of previous studies and published guidelines, nearly two-thirds of patients with T4a larynx ('voice box') cancer are not receiving a total laryngectomy (surgical removal of the larynx), the recommended form of treatment, and as a result, have significantly worse survival rates versus those treated with a total laryngectomy, a new study published in the International Journal of Radiation Oncology, Biology and Physics by experts at Penn Medicine found.

Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-349-5964
University of Pennsylvania School of Medicine

Public Release: 1-Jul-2015
Molecular Cancer Therapeutics
Subcutaneous administration of multispecific antibody improves tumor treatment
Tumor treatment with multispecific antibodies is significantly more tolerable if administered subcutaneously rather than via the bloodstream, which was the standard procedure until now. This was the result of an animal model study undertaken by researchers at Helmholtz Zentrum München in cooperation with the Munich biotech company Trion Research. According to the scientists, the findings published in the journal Molecular Cancer Therapeutics could lead to shorter hospital stays, among other benefits for patients.
Bayerische Forschungsstiftung

Contact: Dr. Ralph Mocikat
Mocikat@helmholtz-muenchen.de
49-893-187-1302
Helmholtz Zentrum München - German Research Center for Environmental Health

Public Release: 1-Jul-2015
PLOS ONE
New drug for neuroblastoma shows promise in phase I study
Researchers at Spectrum Health Helen DeVos Children's Hospital have completed the first clinical trial of a new treatment for children suffering from neuroblastoma. In a clinical trial led by Giselle Sholler, M.D., and the Neuroblastoma and Medulloblastoma Translational Research Consortium, DFMO, an investigational agent, showed minimal side effects with long-term survival of three patients. This is the first clinical study of an oral dosing form of DFMO in any pediatric population.

Contact: Rick Jensen
richard.jensen@spectrumhealth.org
616-391-5291
Spectrum Health

Public Release: 1-Jul-2015
ESMO 17th World Congress on Gastrointestinal Cancer
Thin colorectal cancer patients have shorter survival than obese patients
Although being overweight with a high body-mass index has long been associated with a higher risk for colorectal cancer, thinner patients might not fare as well after treatment for advanced cancer, according to a new study from Duke Medicine.
Genentech Inc.

Contact: Samiha Khanna
samiha.khanna@duke.edu
919-419-5069
Duke University Medical Center

Public Release: 1-Jul-2015
Cancer Cell
Experimental drug combined with standard chemo may shrink ovarian cancers
Working in cell cultures and mice, researchers at Johns Hopkins have found that an experimental drug called fostamatinib combined with the chemotherapy drug paclitaxel may overcome ovarian cancer cells' resistance to paclitaxel.
National Institutes of Health, Conquer Cancer Foundation, HERA Women's Cancer Foundation, Ovarian Cancer Research Fund

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 30-Jun-2015
ACS Nano
Chitosan-coated, chemotherapy-packed nanoparticles may target cancer stem cells
Nanoparticles packed with a clinically used chemotherapy drug and coated with an oligosaccharide derived from the carapace of crustaceans might effectively target and kill cancer stem-like cells, according to a recent study led by researchers at The Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.
American Cancer Society Research Scholar Grant and Pelotonia

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Wexner Medical Center

Public Release: 30-Jun-2015
Oncogene
Colon cancer: Taking a step back to move forward
Recent Weizmann Institute studies are revealing a complex picture of cancer progression in which certain genes that drive tumor growth in the earlier stages get suppressed in later stages -- taking a step back to move forward.

Contact: Yael Edelman
yael.edelman@weizmann.ac.il
Weizmann Institute of Science

Public Release: 30-Jun-2015
Bulletin of the World Health Organization
Epidemic of obesity and overweight linked to increased food energy supply
This study investigates the associations between changes in national food energy supply and average population body weight in 24 high-, 27 middle- and 18 low-income countries. The authors found that the association between change in energy supply and change in weight was statistically significant overall, with findings suggesting that increases in food energy supply are sufficient to explain increases in average population weight.
University of Auckland Vice Chancellor's Strategic Fund, National Institutes of Health

Contact: Fiona Fleck
fleckf@who.int
41-227-911-897
Bulletin of the World Health Organization

Public Release: 30-Jun-2015
Scientific Reports
Similarities between embryos and breast tumors identified
It may seem incredulous, but breast tumors may have something in common with embryos... at least in mice, say researchers at The University of Texas MD Anderson Cancer Center.

Contact: Ron Gilmore
rlgilmore1@mdanderson.org
713-745-1898
University of Texas M. D. Anderson Cancer Center

Public Release: 30-Jun-2015
Technology in Cancer Research & Treatment
Does radiation from X-rays and CT scans really cause cancer?
In recent years, there has been widespread media coverage of studies purporting to show that radiation from X-rays, CT scans and other medical imaging causes cancer. But such studies have serious flaws, including their reliance on an unproven statistical model, according to a recent article in the journal Technology in Cancer Research & Treatment.

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System

Public Release: 30-Jun-2015
Journal of Clinical Oncology
Citrus fruit consumption may be associated with increased melanoma risk
A new analysis of dietary patterns among more than 100,000 Americans suggests that frequent consumption of citrus -- namely whole grapefruit and orange juice -- may be associated with an increased risk of melanoma. Melanoma risk was 36 percent higher in people who consumed citrus fruit or juice at least 1.6 times daily compared to those who consumed them less than twice per week.

Contact: Alise Fisher
alise.fisher@asco.org
571-483-1354
American Society of Clinical Oncology

Public Release: 30-Jun-2015
eLife
Protein's impact on colorectal cancer is dappled
Researchers at University of California, San Diego School of Medicine have discovered a cell signaling pathway that appears to exert some control over initiation and progression of colorectal cancer, the third leading cause of cancer-related death in the United States. A key protein in the pathway also appears to be predictive of cancer survival rates.
National Institutes of Health, Burroughs Wellcome Fund, American Cancer Society

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 30-Jun-2015
Scientific Reports
Atomic force microscope advance leads to new breast cancer research
Researchers who developed a high-speed form of atomic force microscopy have shown how to image the physical properties of live breast cancer cells, for the first time revealing details about how deactivation of a key protein may lead to metastasis.
National Science Foundation, National Institutes of Health

Contact: emil Venere
venere@purdue.edu
765-494-4709
Purdue University

Showing releases 201-225 out of 1363.

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