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Showing releases 201-225 out of 1364.

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Public Release: 7-May-2015
Cell
Patient cancer cells help to test treatments
Organoids, small clusters of cells that accurately mimic the behavior of human tissue, can be used to test cancer drugs and, eventually, to identify effective personalized treatments for patients. Samples from healthy tissue and cancerous tissue were taken from 20 patients with colorectal carcinoma and used to form the organoids. Tests showed that the organoids faithfully replicated many important features of patient tumors.
Stichting Virtutis Opus and Stitchting Vrienden van het Hubrecht, Alpe dHuzes/KWF, Dutch Cancer Society

Contact: Mary Clarke
press.office@sanger.ac.uk
01-223-492-368
Wellcome Trust Sanger Institute

Public Release: 7-May-2015
Cell
3-D 'organoids' grown from patient tumors could personalize drug screening
Three-dimensional cultures (or 'organoids') derived from the tumors of cancer patients closely replicate key properties of the original tumors, reveals a study published May 7 in Cell. These 'organoid' cultures are amenable to large-scale drug screens for the detection of genetic changes associated with drug sensitivity and pave the way for personalized treatment approaches that could optimize clinical outcomes in cancer patients.

Contact: Joseph Caputo
jcaputo@cell.com
617-335-6270
Cell Press

Public Release: 7-May-2015
Science
Penn team finds protein 'cement' that stabilizes the crossroad of chromosomes
A new study describes how the centromere is stabilized during replication. The structure and biology of the centromere is of considerable scientific interest because problems with it can lead to abnormalities in the chromosomes of daughter cells, which are the basis of such disorders as Down syndrome. As it turns out, the centromere is distinguished not only by its DNA sequence but also by a special type of nucleosome, which includes a protein called CENP-A.
NIH/National Institute of General Medical Sciences, NIH/National Cancer Institute, National Science Foundation, National Institute of Standards and Technology, American Heart Association, American Cancer Society, European Research Council

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 7-May-2015
American Urological Association 2015 Annual Meeting
Myriad to present new clinical data on Prolaris at the AUA 2015 Annual Meeting
Myriad will present data from three studies that demonstrate the value of the Prolaris test at the AUA 2015 annual meeting. The presentations will showcase a new 'active surveillance threshold' for men with localized prostate cancer based on the Prolaris test score, and the final results from PROCEDE 1000, which is the largest prospective clinical utility study to measure the impact of the Prolaris test on the treatment of men with localized prostate cancer.

Contact: Ron Rogers
rrogers@myriad.com
801-584-3065
Myriad Genetics, Inc.

Public Release: 7-May-2015
JAMA Otolaryngology - Head & Neck Surgery
Impact of post-treatment surveillance in head and neck squamous cell cancer
Compliance with post-treatment surveillance, income level and the travel distance for follow-up care had effects on survival in patients with head and neck squamous cell cancer, according to a report published online by JAMA Otolaryngology-Head & Neck Surgery.

Contact: Natalie Lutz
nlutz3@kumc.edu
913-588-2598
The JAMA Network Journals

Public Release: 7-May-2015
JAMA Oncology
Statins associated with longer prostate cancer time to progression during ADT
The use of cholesterol-lowering statins when men initiated androgen deprivation therapy for prostate cancer was associated with longer time to progression of the disease, according to an article published online by JAMA Oncology.

Contact: John W. Noble
johnw_noble@dfci.harvard.edu
617-632-5784
The JAMA Network Journals

Public Release: 7-May-2015
Genetics in Medicine
Study reveals why almost half of patients opt out of comprehensive cancer testing
Some at-risk patients opted out of comprehensive cancer gene screening when presented with the opportunity to be tested for the presence of genes linked to various cancers, according to a recent study led by researchers at the Perelman School of Medicine at the University of Pennsylvania. Concern for uncertainty and potential distress were cited among the most common reasons to refuse testing.

Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-349-5964
University of Pennsylvania School of Medicine

Public Release: 7-May-2015
Current Biology
TSRI researchers connect haywire protein to breast cancer, leukemia
A new study led by scientists at The Scripps Research Institute sheds light on the cause of some cancers, including breast cancer and leukemia. In the new study, the researchers found that too much of a key protein, called cyclin E, slows down DNA replication and introduces potentially harmful cancer-linked mutations when cells divide.
National Institutes of Health, Pew Latin American Fellows Program in the Biomedical Sciences

Contact: Madeline McCurry-Schmidt
madms@scripps.edu
858-784-9254
Scripps Research Institute

Public Release: 7-May-2015
Cell Reports
Scientists show the mammary gland 'remembers' prior pregnancy, spurring milk production
Anecdotal reports of nursing mothers have long suggested that giving milk is a lot easier in second and subsequent pregnancies, compared with a first pregnancy. Now, researchers can explain why. Their work shows the mammary gland forms a long-term memory of pregnancy that primes it to respond to the hormonal changes that announce succeeding pregnancies.
National Institutes of Health, CSHL Cancer Center

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Public Release: 7-May-2015
Cell Metabolism
Study finds metabolic link between bacterial 'biofilms' and colon cancer
A team led by scientists at The Scripps Research Institute and Johns Hopkins University School of Medicine has uncovered a big clue to how bacteria may promote some colon cancers.
California Institute of Regenerative Medicine, National Institutes of Health, US Department of Energy

Contact: Madeline McCurry-Schmidt
madms@scripps.edu
858-784-9254
Scripps Research Institute

Public Release: 7-May-2015
JAMA Oncology
Statin drugs can delay prostate cancer progression in patients, study shows
Men who went on cholesterol-lowering statin drugs when they began androgen deprivation therapy for prostate cancer had a longer time in which their disease was under control than did men who didn't take statins, a clinical trial led by Dana-Farber Cancer Institute investigators shows.
Dana-Farber Prostate Cancer Specialized Program of Research Excellence, US Department of Defense

Contact: John Noble
johnw_noble@dfci.harvard.edu
617-632-5784
Dana-Farber Cancer Institute

Public Release: 6-May-2015
European Radiology
New method detects more breast cancer in screening
Tomosynthesis detects 40 percent more breast cancers than traditional mammography does, according to a major screening study from Lund University, Sweden. This is the first large-scale study to compare the screening method with regular mammograms. The 3-D X-ray technique is also more comfortable for women, as breast compression is halved.

Contact: Sophia Zackrisson
sophia.zackrisson@med.lu.se
46-403-38797
Lund University

Public Release: 6-May-2015
BMC Medicine
A healthy lifestyle before bowel cancer diagnosis could help improve survival
Following lifestyle guidelines about diet, physical activity and maintaining a healthy weight is associated with an improved likelihood of survival when diagnosed with bowel cancer. This is based on the findings of a large study of over 500,000 published in the open-access journal BMC Medicine.

Contact: Shane Canning
shane.canning@biomedcentral.com
44-203-192-2243
BioMed Central

Public Release: 6-May-2015
Immunity
Study discovers negative regulator of natural killer cell maturation
A new study has identified a regulatory pathway in natural killer cells that inhibits their maturation and homing behavior. Natural killer cells are one of the body's first lines of defense against viruses and cancer. The findings could lead to new strategies for boosting natural-killer cell activity against cancer and viral infections.
National Institutes of Health, National Blood Foundation, American Cancer Society, Gabrielle's Angel Foundation for Cancer Research, Natural Science Foundation of China, European Research Council, The Ligue Nationale contre le Cancer

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Wexner Medical Center

Public Release: 6-May-2015
The British Psychological Society Annual Conference
Psychologists aim to help Dr. Google
This is one of the outcomes from research by Ph.D. student Julia Mueller based in the School of Nursing, Midwifery and Social Work at the University of Manchester (part of the Manchester Cancer Research Centre) who will present her study today, Thursday, May 7, 2015, at the Annual Conference of the British Psychology Society being held in Liverpool.
Medical Research Council

Contact: Kathryn McCullagh
presscentre@bps.org.uk
01-517-074-642
British Psychological Society

Public Release: 5-May-2015
Oral Oncology
Profiling approach to enable right lung cancer treatment match
Manchester researchers have tested a new way to genetically profile lung cancer samples, potentially allowing doctors to more easily identify the most appropriate treatment for patients.

Contact: Jamie Brown
jamie.brown@manchester.ac.uk
01-612-758-383
University of Manchester

Public Release: 5-May-2015
Dentistry
Treating gum disease reduces prostate symptoms, CWRU researchers find
Treating gum disease reduced symptoms of prostate inflammation, called prostatitis, report researchers from Case Western Reserve University School of Dental Medicine and the Departments of Urology and Pathology at University Hospitals Case Medical Center.
Case Western Reserve University School of Dental Medicine and University Hospitals Case Medical Center

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University

Public Release: 5-May-2015
Cell Reports
Breast cancer vaccines may work better with silicon microparticles
The effectiveness of cancer vaccines could be dramatically boosted by first loading the cancer antigens into silicon microparticles, report scientists from Houston Methodist and two other institutions in an upcoming Cell Reports.
US Department of Defense, National Institutes of Health, Cancer Prevention Research Institute of Texas

Contact: David Bricker
dmbricker@houstonmethodist.org
832-667-5811
Houston Methodist

Public Release: 5-May-2015
Practical Radiation Oncology
ASTRO issues guideline on definitive and adjuvant RT for locally advanced non-small cell lung cancer
The American Society for Radiation Oncology is issuing a new guideline, 'Definitive and adjuvant radiotherapy in locally advanced non-small cell lung cancer: An American Society for Radiation Oncology evidence-based clinical practice guideline.'

Contact: Michelle Kirkwood
press@astro.org
703-286-1600
American Society for Radiation Oncology

Public Release: 4-May-2015
Youth just as likely to try e-cigarettes as smoking
Young people are just as likely to try electronic cigarettes as smoking, according to a new report from the Propel Centre for Population Health Impact at the University of Waterloo.

Contact: Pamela Smyth
psmyth@uwaterloo.ca
519-888-4777
University of Waterloo

Public Release: 4-May-2015
Science
Proteomics identifies DNA repair toolbox
Various repair mechanisms help our cells to revert continuous damage to their DNA. If they fail, mutations accumulate that can lead to devastating diseases. DNA repair defects underlie predisposition to certain cancers and promote the transformation process in other spontaneous cancers. Using highly sensitive proteomic technologies, scientists of the Max Planck Institute of Biochemistry now report in the journal Science the first global analysis of the protein recruitment dynamics underlying a critical DNA repair pathway.

Contact: Anja Konschak
konschak@biochem.mpg.de
49-898-578-2824
Max Planck Institute of Biochemistry

Public Release: 4-May-2015
Nature Methods
Scientists dramatically improve method for finding common genetic alterations in tumors
St. Jude Children's Research Hospital scientists have developed a significantly better computer tool for finding genetic alterations that play an important role in many cancers but were difficult to identify with whole-genome sequencing. The findings appear today in the scientific journal Nature Methods.
Pediatric Cancer Genome Project, Kay Jewelers, NIH/National Cancer Institute, and ALSAC

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Public Release: 4-May-2015
Journal of Nuclear Medicine
Recurrence of prostate cancer detected earlier with innovative PSMA-ligand PET/CT
A recent study reported in The Journal of Nuclear Medicine compared use of the novel Ga-68-PSMA-ligand PET/CT with other imaging methods and found that it had substantially higher detection rates of prostate-specific membrane antigen in patients with biochemical recurrence after radical prostatectomy. It is especially noteworthy that this hybrid PSMA-ligand identified a large number of positive findings in the clinically important range of low PSA-values (<0.5ng/mL).
European Union Seventh Framework Program

Contact: Laurie Callahan
lcallahan@snmmi.org
703-652-6773
Society of Nuclear Medicine

Public Release: 4-May-2015
Moderate exercise may make cancer treatments more effective, kinesiologist finds
Kansas State University kinesiology research offers encouraging information for cancer patients: A brisk walk or a slow jog on a regular basis may be the key to improved cancer treatments.
American Cancer Society

Contact: Brad Behnke
bjbehnke@k-state.edu
785-532-6765
Kansas State University

Public Release: 4-May-2015
Nature Genetics
Discovery could help reverse glucocorticoid resistance in some young leukemia patients
Researchers led by St. Jude Children's Research Hospital scientists have identified a mechanism that helps leukemia cells resist glucocorticoids, a finding that lays the foundation for more effective treatment of cancer and possibly a host of autoimmune diseases.
National Institutes of Health; American Recovery and Reinvestment Act supplement; American Lebanese Syrian Associated Charities

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Showing releases 201-225 out of 1364.

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