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Showing releases 201-225 out of 1306.

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Public Release: 29-Oct-2015
CA: A Cancer Journal for Clinicians
Breast cancer becoming as common among African-American women as among white women
Breast Cancer Statistics, 2015 finds rates among African-American women in the United States have continued to increase, converging with rates among white women and closing a gap that had existed for decades.
American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 29-Oct-2015
2015 American Association of Pharmaceutical Scientists Annual Meeting and Exposition
Novel nanoparticles for image-guided phototherapy could improve ovarian cancer treatments
Scientists are investigating a biodegradable nanomedicine that can selectively destroy ovarian cancer cells left behind after surgery. These findings are a step forward in the development of targeted therapies for hard-to-treat cancers. This work is being presented Oct. 29 at the 2015 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, the world's largest pharmaceutical sciences meeting, in Orlando, Fla. Oct. 25-29.
Oregon State College of Pharmacy, Oregon State Venture Development Fund and Oregon State General Research Fund

Contact: Amanda Johnson
American Association of Pharmaceutical Scientists

Public Release: 29-Oct-2015
Cell Reports
Wistar scientists show how frequently mutated prostate cancer gene suppresses tumors
New research from The Wistar Institute has found how SPOP, a gene frequently mutated in prostate cancer, is able to halt tumors by inducing senescence, a state of stable cell cycle arrest, which means that the cells have stopped dividing and growing. With this new information, scientists may be able to design therapeutic strategies that can halt cancers caused by these mutated genes that are able to bypass senescence.
National Institutes of Health, US Department of Defense

Contact: Ben Leach
The Wistar Institute

Public Release: 29-Oct-2015
Cancer Discovery
Splicing alterations that cause resistance to CD19 CAR T-cell therapy identified
Resistance to CD19 CAR T-cell therapy, a type of immunotherapy that yields long-lasting remissions in many patients with B-cell leukemia, can be caused by CD19 splicing alterations, leading to loss of certain parts of the CD19 protein that are recognized by the CAR T cells.
V Foundation for Cancer Research, William Lawrence and Blanche Hughes Foundation, Leukemia and Lymphoma Society, Alex's Lemonade Stand, National Institutes of Health, SU2C-St. Baldrick's Foundation

Contact: Lauren Riley
American Association for Cancer Research

Public Release: 28-Oct-2015
Autophagy works in cell nucleus to guard against start of cancer
Autophagy, the degradation of unwanted cellular bits and pieces by the cell itself, has been shown for the first time to also work in the cell nucleus. In addition, in this setting autophagy plays a role in guarding against the start of cancer and is related to the aging process.
National Institutes of Health, Leukemia & Lymphoma Society, Dermatology Foundation, Melanoma Research Foundation, American Skin Association, and Progeria Research Foundation

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 28-Oct-2015
2015 American Association of Pharmaceutical Scientists Annual Meeting and Exposition
Radiotherapeutic bandage shows potential as treatment for skin cancer
A radiotherapeutic bandage is being evaluated by researchers for efficacy against squamous cell carcinoma (SCC) in an animal model. These results could confirm the viability of a new and improved strategy for the radiotherapeutic treatment of skin cancer in the clinic. This work is being presented Oct. 28 at the 2015 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, the world's largest pharmaceutical sciences meeting, in Orlando, Fla. Oct. 25-29.
Texas Medical Research Collaborative and Sigma Xi, The Scientific Research Society.

Contact: Amanda Johnson
American Association of Pharmaceutical Scientists

Public Release: 28-Oct-2015
The first 'molecular labels' that predict the organs where metastases will form, discovered
Researchers have discovered that primary tumors send messenger 'bubbles' capable of transforming the environments in metastatic organs, in a way that makes them more welcoming for tumor cells. In addition, these tumor 'scouts' have different molecular labels which, like zip codes, allow them to nest in specific organs. The finding is considered one of the most important advances for over a century in addressing the challenge of predicting where tumor metastases will occur.

Contact: Nuria Noriega
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 28-Oct-2015
Genome Research
Retroviral RNA may play a part in liver cancer
Researchers have found that retroviral long-terminal-repeat (LTR) promoters -- a type of repetitive element that are widely distributed in the human genome -- are highly activated in hepatocellular carcinomas, the most common type of liver cancer. Intriguingly, these areas -- which are particularly activated in HCCs associated with viral hepatitis, are not normally activated in the liver but are in reproductive tissues such as testis and placenta.

Contact: Jens Wilkinson

Public Release: 28-Oct-2015
New England Journal of Medicine
Landmark clinical trial shows gene-targeted drug can treat prostate cancer
A pioneering drug developed to treat women with inherited cancers can also benefit men with advanced prostate cancer, a major new clinical trial concludes. The trial is a milestone in cancer treatment as the first to show the benefits of 'precision medicine' in prostate cancer -- with treatment matched to the particular genetic characteristics of a man's tumor.
Cancer Research UK, Prostate Cancer Foundation, Stand Up To Cancer, Prostate Cancer UK, Movember Foundation

Contact: Henry French
Institute of Cancer Research

Public Release: 28-Oct-2015
Science Translational Medicine
Mount Sinai scientists deploy data analysis to identify subtypes of common disease
Large-scale network analysis uses electronic medical records, genotype data to reveal three patient subtypes of type 2 diabetes; possibility for targeted care in future.

Contact: Glenn Farrell
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 28-Oct-2015
Food Control
Some commercial coffees contain high levels of mycotoxins
An analysis of 100 coffees sold in Spain has confirmed the presence of mycotoxins -- toxic metabolites produced by fungi. In addition, five of the samples that were tested were found to contain ochratoxin A, the only legislated mycotoxin, in amounts that exceeded maximum permitted levels. While the authors point out that these results are not alarming, they do recommend assessing the risk that exposure to mycotoxins from coffee poses to the general public.

Contact: SINC
FECYT - Spanish Foundation for Science and Technology

Public Release: 28-Oct-2015
Marketing Science
Increasing cigarette taxes shifts consumers to more dangerous products: INFORMS journal study
Increasing cigarette exercise taxes may have the unintended consequence of encouraging consumers to seek higher nicotine content and more dangerous cigarette products, according to a study published in Marketing Science, a journal of the Institute for Operations Research and the Management Sciences.

Contact: Barry List
Institute for Operations Research and the Management Sciences

Public Release: 28-Oct-2015
British Medical Journal
New guidelines aim to enhance accuracy of medical tests
Seeking to improve the reliability of medical testing, an international team of top experts is releasing new guidelines for doctors and scientists on how to best report their assessments of new and existing diagnostic tests.

Contact: Josh Barney
University of Virginia Health System

Public Release: 27-Oct-2015
Nature Communications
Genetic testing could identify men at a 10-fold increased risk of testicular cancer
A new study of more than 25,000 men has uncovered four new genetic variants associated with increased risk of testicular cancer. Testing for these variants combined with all 21 previously identified using genetic sequencing identified men with a 10-fold higher risk of testicular cancer than the population average.
Movember Foundation, Institute of Cancer Research, Cancer Research UK

Contact: Claire Hastings
Institute of Cancer Research

Public Release: 27-Oct-2015
UEG Week 2015
Increased risk of large bowel cancer for each 1 cm rise in waist circumference
New research shows an increased risk of large bowel cancer for each 1 cm rise in waist circumference. In addition, in men, there is now evidence that increasing waist circumference in middle age is associated with increased bowel cancer risk.

Contact: Luke Paskins
Spink Health

Public Release: 27-Oct-2015
UEG Week 2015
Improving risk profiling is key to preventing many GI cancers
Today, experts at United European Gastroenterology call for better risk profiling for all GI cancers in order to develop more targeted approaches to their screening and prevention.

Contact: Luke Paskins
Spink Health

Public Release: 27-Oct-2015
Nuclear Medicine Communications
One hundred cancer patients a year in Manchester benefit from new scan technology
Researchers in Manchester have used recent advances in PET scanning technology to reduce the radiation dose for both patients and staff by up to 30 percent, allowing an addition of an annual 100 scans a year at Central Manchester University Hospitals.

Contact: Jamie Brown
University of Manchester

Public Release: 27-Oct-2015
Drug for digestive problem can extend survival for many advanced cancer patients
Advanced cancer patients given a drug designed to relieve constipation caused by pain killers lived longer with less tumor progression than those who did not receive or respond to the drug, researchers report at the American Society of Anesthesiologists. This is the first study in humans to associate opioid blockade with longer survival. It suggests that methylnaltrexone, approved in 2008 for prevention of opioid-induced constipation, should play a larger role in cancer therapy.
University of Chicago

Contact: John Easton
University of Chicago Medical Center

Public Release: 27-Oct-2015
New finding offers clues for blocking cancer gene
A new study suggests a potential new way to block Notch, one of the most common cancer-causing genes, without causing severe side effects.
American Cancer Society, Elisa U. Pardee Foundation, Rally Foundation for Childhood Cancer Research, Vs. Cancer Foundation, Bear Necessities Pediatric Cancer Foundation, Concern Foundation, American Society of Hematology, National Institutes of Health

Contact: Nicole Fawcett
University of Michigan Health System

Public Release: 27-Oct-2015
Lancet Oncology
Inherited gene variation linked to an increased risk of the most common childhood cancer
For two generations of one family, inherited variation in the ETV6 gene linked to an increased risk of childhood acute lymphoblastic leukemia.
National Institutes of Health, American Society of Hematology, Order of St. Francis Foundation, Mie Prefecture

Contact: Frannie Marmorstein
St. Jude Children's Research Hospital

Public Release: 27-Oct-2015
Annals of Oncology
Study shows association between breastfeeding and reduced risk of aggressive breast cancer
A large international study shows that breastfeeding is associated with a lower risk of developing an aggressive form of breast cancer called hormone-receptor negative.

Contact: Pamela Green
American Cancer Society

Public Release: 27-Oct-2015
Journal of Neurochemistry
New finding helps explain why many alcohol drinkers also are smokers
Alcohol and nicotine use have long been known to go hand in hand. Previous research shows that more than 85 percent of US adults who are alcohol-dependent also are nicotine-dependent. Now, researchers from the University of Missouri School of Medicine have found that nicotine cancels out the sleep-inducing effects of alcohol. It's a finding that sheds light on the reason alcohol and nicotine usage are so closely linked.
NIH/National Institute of Alcohol Abuse and Alcoholism

Contact: Derek Thompson
University of Missouri-Columbia

Public Release: 27-Oct-2015
Nature Medicine
3-D pancreatic cancer organoid may help predict clinical responses, personalize treatments
A new method to grow 3-D organoid cultures of pancreatic tumors directly from surgical tissue offers a promising opportunity for testing targeted therapies and personalizing treatments in a rapid, cost-effective manner.

Contact: Bonnie Prescott
Beth Israel Deaconess Medical Center

Public Release: 27-Oct-2015
Clinical Cancer Research
Potential new therapy for triple-negative breast cancer shows promise in lab studies
Recent laboratory findings provide novel insight into potential new therapeutic approaches for triple-negative breast cancer, a particularly difficult to treat and aggressive form of the disease.

Contact: Beth Hinshaw Hall
Van Andel Research Institute

Public Release: 27-Oct-2015
Scientific Reports
Researchers explore natural molecule's potential to aid immune response
Proteins called cytokines are known to influence immune cell fate, but the process is complex. Researchers examined how a specific cytokine, interleukin-15, influences gene expression patterns in T helper cells.

Contact: Paula Brewer Byron
Virginia Tech

Showing releases 201-225 out of 1306.

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