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Showing releases 201-225 out of 1324.

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Public Release: 27-Jul-2015
Proceedings of the National Academy of Sciences
In CRISPR advance, scientists successfully edit human T cells
In a project spearheaded by investigators at UC San Francisco, scientists have devised a new strategy to precisely modify human T cells using the genome-editing system known as CRISPR/Cas9. Because these immune-system cells play important roles in a wide range of diseases, from diabetes to AIDS to cancer, the achievement provides a versatile new tool for research on T cell function, as well as a path toward CRISPR/Cas9-based therapies for many serious health problems.
National Institutes of Health, National MS Society, Howard Hughes Medical Institute

Contact: Pete Farley
peter.farley@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 27-Jul-2015
Oncogene
Study finds non-genetic cancer mechanism
Cancer can be caused solely by protein imbalances within cells, a study of ovarian cancer has found.
G. Harold and Leila Y. Mathers Charitable Foundation, National Institute of Health, RGK Foundation, Gilder Foundation

Contact: Chris Bunting
c.j.bunting@leeds.ac.uk
44-011-334-32049
University of Leeds

Public Release: 27-Jul-2015
Cancer
Many young cancer patients may have limited awareness of fertility preservation options
A new study points to the need for increased awareness of fertility preservation options for young patients with cancer.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
Wiley

Public Release: 27-Jul-2015
Journal of Clinical Investigation
Flow means 'go' for proper lymph system development
The lymph system provides a slow flow of fluid from tissues into the blood. It returns fluid and proteins that leak from blood vessels, provides passage for immune cells from the tissues to the blood, and hosts key niches for immune cells. How this system develops hasn't been well understood, but now researchers have found from that the early flow of lymph fluid is a critical factor in the development of mature lymphatic vessels.
National Institutes of Health, Leducq Foundation

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine

Public Release: 27-Jul-2015
Journal of Clinical Oncology
Breast cancer survivors who experience pain during intercourse may benefit from lidocaine
Scientists at Oregon Health & Science University report that breast cancer survivors who experience pain during sexual intercourse, a common side effect of breast cancer treatment, may achieve comfort when liquid lidocaine is applied strategically to prevent pain. Their research was published online today in the Journal of Clinical Oncology.
Oregon Health & Science University Center for Women's Health Circle of Giving

Contact: Ariane Le Chevallier
holma@ohsu.edu
503-494-8231
Oregon Health & Science University

Public Release: 27-Jul-2015
Proceedings of the National Academy of Sciences
Gene therapy may improve survival of patients with recurrent ovarian cancer
Use of gene therapy to deliver a protein that suppresses the development of female reproductive organs may improve the survival of patients with ovarian cancer that has recurred after chemotherapy, which happens 70 percent of the time and is invariably fatal.
Ovarian Cancer Research Fund, Sudna Gar Foundation, US Department of Defense, National Institutes of Health

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital

Public Release: 27-Jul-2015
Proceedings of the National Academy of Sciences
Narrowing in on pituitary tumors
In a new study published in the Proceedings of the National Academy of Sciences on July 27, investigators from Brigham and Women's Hospital present a new technique that could help surgeons more precisely define the locations of pituitary tumors in near real-time.
National Institutes of Health, US Army Medical Research/CIMIT, National Center for Image Guided Therapy

Contact: Haley Bridger
hbridger@partners.org
617-525-6383
Brigham and Women's Hospital

Public Release: 27-Jul-2015
Cancer Discovery
Clinical validation for LOXO-101 against TRK fusion cancer
Published today in Cancer Discovery, first imaging studies conducted post-treatment, confirmed that stage IV patient's tumors had substantially regressed. With four months of treatment, additional CT scans demonstrated almost complete disappearance of the largest tumors.
V Foundation Scholar Award, Loxo Oncology Research Grant, State of Colorado and University of Colorado Technology Transfer Office Bioscience Discovery Evaluation Grant Program, University of Colorado Lung Cancer SPORE

Contact: Erika Matich
erika.matich@ucdenver.edu
University of Colorado Anschutz Medical Campus

Public Release: 27-Jul-2015
Cell Reports
In lab tests, new therapy slows spread of deadly brain tumor cells
The rapid spread of a common and deadly brain tumor has been slowed down significantly in a mouse model by cutting off the way some cancer cells communicate, according to a team of researchers that includes UF Health faculty.
American Cancer Society, National Institutes of Health, Sontag Foundation, Lerner Research Institute, Florida Center for Brain Tumor Research

Contact: Doug Bennett
dougbennett@ufl.edu
352-273-5706
University of Florida

Public Release: 27-Jul-2015
Nature Genetics
New treatment options for a fatal leukemia
In industrialized countries like in Europe, acute lymphoblastic leukemia is the most common form of cancer in children. An international research consortium lead by pediatric oncologists from the universities of Zurich and Hannover has now succeeded in decoding a specific form of this leukemia, which is regarded as incurable, and in obtaining insights for new therapeutic possibilities.

Contact: Jean-Pierre Bourqin
Jean-Pierre.Bourquin@kispi.uzh.ch
41-793-650-837
University of Zurich

Public Release: 27-Jul-2015
Tissue Engineering
Scientists' silk structure is secret to process of regenerating salivary cells
A research team led by Chih-Ko Yeh, B.D.S., Ph.D., from The University of Texas Health Science Center at San Antonio, is the first to use silk fibers as a framework to grow stem cells into salivary gland cells. The new process could provide relief for millions of individuals with dry mouth, including patients with Sjögren's syndrome, survivors of head and neck cancer, and those who take drugs with a side effect that limits saliva production.
NIH/National Institute of Dental and Craniofacial Research, Veterans Administration

Contact: Rosanne Fohn
fohn@uthscsa.edu
210-567-3026
University of Texas Health Science Center at San Antonio

Public Release: 27-Jul-2015
Nature Genetics
Yale study identifies 'major player' in skin cancer genes
A multidisciplinary team at Yale, led by Yale Cancer Center members, has defined a subgroup of genetic mutations that are present in a significant number of melanoma skin cancer cases. Their findings shed light on an important mutation in this deadly disease, and may lead to more targeted anti-cancer therapies.
Yale SPORE in Skin Cancer, NIH/National Cancer Institute, US National Institutes of Health, Melanoma Research Alliance, Gilead Sciences, Inc., Howard Hughes Medical Institute

Contact: Ziba Kashef
ziba.kashef@yale.edu
203-436-9317
Yale University

Public Release: 24-Jul-2015
Nature Communications
Scientists discover first 'DNA ambulance'
U of T researchers have discovered how severely damaged DNA is transported within a cell and how it is repaired. It's a discovery that could unlock secrets into how cancer operates -- a disease that two in five Canadians will develop in their lifetime.

Contact: Katie Babcock
Katie.Babcock@utoronto.ca
416-946-7707
University of Toronto

Public Release: 24-Jul-2015
British Journal of Cancer
University of York scientists discover why some tumors are resistant to radiotherapy
Scientists at the University of York believe they have identified how some tiny regulatory molecules in cells can make prostate cancers resistant to radiotherapy. It is hoped that this new development could pave the way for more effective treatments -- allowing a lower dose of radiotherapy to be used while prolonging the lives of thousands of men.
PRO-NEST Marie Curie, The Finnish Funding Agency for Technology and Innovation Finland Distinguished Professor, and Academy of Finland, Cancer Research Technology and Yorkshire Cancer Research

Contact: David Garner
david.garner@york.ac.uk
44-019-043-22153
University of York

Public Release: 24-Jul-2015
Science Advances
TOPLESS plants provide clues to human molecular interactions
Van Andel Research Institute scientists have unraveled how an important plant protein, known as TOPLESS, interacts with other molecules responsible for turning genes off. The findings in plants provide a general model across species for this type of gene silencing, which is linked to several vital biological functions in humans.

Contact: Beth Hinshaw Hall
Beth.HinshawHall@vai.org
616-234-5519
Van Andel Research Institute

Public Release: 24-Jul-2015
Deutsches Ärzteblatt International
Prostate cancer not caused by shift work
In a recent original article in Deutsches Ärzteblatt International, Gael P. Hammer et al. show that shift workers do not develop prostate cancer more frequently than their colleagues who work during the day.

Contact: Dr. Gaël P. Hammer
gael.hammer@lns.etat.lu
Deutsches Aerzteblatt International

Public Release: 23-Jul-2015
Nature Methods
Web app helps researchers explore cancer genetics
As gene sequencing has gotten faster and cheaper, clinicians and researchers are able to use genomic data to study, diagnose, and develop a course of treatment for a variety of individual cancers. MAGI, an open-source tool developed by Brown University researchers, lets users compare their data with enormous cancer genetics datasets.
National Institutes of Health

Contact: Kevin Stacey
kevin_stacey@brown.edu
401-863-3766
Brown University

Public Release: 23-Jul-2015
Endocrine Related Cancers
Mayo researchers decode molecular action of combination therapy for deadly thyroid cancer
In their bid to find the best combination of therapies to treat anaplastic thyroid cancer, researchers on Mayo Clinic's Florida campus demonstrated that all histone deacetylase inhibitors are not created equal.
National Institute of Health and Medical Research, Florida Department of Health Bankhead-Coley Cancer Research Program

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-0746
Mayo Clinic

Public Release: 23-Jul-2015
Genome Medicine
Novel algorithm identifies DNA copy-number landscapes in African American colon cancers
The algorithm ENVE could be the Google for genetic aberrations -- and it comes from Case Western Reserve. The findings about the algorithm that distinguishes 'noise' from real evidence, as well as some genetic characteristics of colon cancer in African Americans, appears this week in Genome Medicine.
US Public Health Service, GI SPORE, Breast Cancer Research Foundation, Rosalie and Morton Cohen Family Memorial Genomics Fund of University Hospitals Case Medical Center, Clinical and Translational Collaborative of Cleveland

Contact: Jeannette Spalding
jeannette.spalding@case.edu
216-368-3004
Case Western Reserve University

Public Release: 23-Jul-2015
ecancermedicalscience
Resolving the cancer/diet paradox: New special issue on cancer in metabolism
How much does diet affect the cancer patient? Do 'antioxidants' really play an important role in health -- or are they causing more cancers than they cure? And what exactly is the relationship between obesity and cancer? The latest Special Issue in ecancermedicalscience collects four original articles from experts in cancer and metabolism, addressing the hottest areas of research in this rapidly developing field.

Contact: Audrey Nailor
audrey@ecancer.org
44-011-790-94742
ecancermedicalscience

Public Release: 23-Jul-2015
Proposed 2016 Medicare physician cuts threaten access to community-based radiation therapy
The American Society for Radiation Oncology (ASTRO) is concerned about proposed additional payment cuts to radiation therapy detailed in the Centers for Medicare and Medicaid Services' (CMS) proposed Medicare Physician Fee Schedule (MPFS), released July 8, 2015, which will take effect on Jan. 1, 2016. Freestanding centers estimate that the combined impact of the Medicare proposals would result in a five to seven percent reduction in payment for radiation oncology services at community-based centers.

Contact: Michelle Kirkwood
michellek@astro.org
703-286-1600
American Society for Radiation Oncology

Public Release: 23-Jul-2015
JAMA
For prostate cancer patients, risk-specific therapies now more the norm
After decades of overtreatment for low-risk prostate cancer and inadequate management of its more aggressive forms, patients are now more likely to receive medical care matched to level of risk, according to a study by researchers at UC San Francisco.

Contact: Suzanne Leigh
Suzanne.Leigh@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 23-Jul-2015
Gut
Researchers find new method to halt the advance of liver cancer
Study suggests that drugs targeting the lymphotoxin-beta receptor may improve liver cancer treatment.
National Institutes of Health

Contact: Susan Gammon
sgammon@sbpdiscovery.org
858-795-5012
Sanford-Burnham Prebys Medical Discover Institute

Public Release: 23-Jul-2015
Blood
Stem cell transplantation for children with rare form of leukemia improves outcomes
Researchers in the Division of Hematology, Oncology and Blood & Marrow Transplantation at Children's Hospital Los Angeles have shown greatly improved outcomes in using stem cell transplantation to treat patients with a serious but very rare form of chronic blood cancer called juvenile myelomonocytic leukemia.

Contact: Debra Kain
dkain@chla.usc.edu
323-361-7628
Children's Hospital Los Angeles

Public Release: 23-Jul-2015
Journal of Women's Health
Can patient navigators reduce no-shows for cancer screening follow-up?
Researchers at Harvard Medical School and Brigham and Women's Hospital reported a 20 percent decline in the rate of missed appointments for cervical cancer evaluation following a Pap smear when a patient navigator program was initiated at the referral center. The impact of the program and the main reasons for patient no-shows are explored in an article in Journal of Women's Health.

Contact: Kathryn Ryan
kryan@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

Showing releases 201-225 out of 1324.

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