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Public Release: 2-Jun-2016
Researchers uncover how 'silent'genetic changes drive cancer
Small molecules called tRNA, whose job is to help translate genes into proteins, are not usually considered important for understanding the causes of disease. But a new study shows that fluctuations in some tRNAs may in fact influence the progression of breast cancer.
National Institutes of Health, Department of Defense

Contact: Eva Kiesler
Rockefeller University

Public Release: 2-Jun-2016
JAMA Oncology
Frailty among young bone marrow transplant survivors increases risk of death
The prevalence of frailty in young bone marrow transplant survivors is similar to that seen in the elderly population and frailty is associated with an increased risk of subsequent death, according to a new study published online by JAMA Oncology.

Contact: Beena Thannickal
The JAMA Network Journals

Public Release: 2-Jun-2016
Nature Communications
CNIO scientists have created mice with hyper-long telomeres without altering the genes
The Telomeres and Telomerase Group at the CNIO has succeeded in creating mice in the laboratory with hyper-long telomeres and with reduced molecular ageing, avoiding the use of genetic manipulation. This new technique based on epigenetic changes avoids the manipulation of genes in order to delay molecular ageing. The study also underlines the importance of this new strategy in generating embryonic stem cells and iPS cells with long telomeres for use in regenerative medicine.
Spanish Ministry of Economy and Competitiveness, European Research Council, Regional Government of Madrid, AXA Research Fundation, Botín Foundation and Banco Santander through Santander Universities

Contact: Nuria Noriega
Centro Nacional de Investigaciones Oncológicas (CNIO)

Public Release: 2-Jun-2016
Study provides new clues to leukemia resurgence after chemotherapy
For the first time, researchers have discovered that some leukemia cells harvest energy resources from normal cells during chemotherapy, helping the cancer cells not only to survive, but actually thrive, after treatment. The study is published online today in Blood, the Journal of the American Society of Hematology.

Contact: Stephen Fitzmaurice
American Society of Hematology

Public Release: 2-Jun-2016
CA: A Cancer Journal for Clinicians
Cancer survivors: A growing population
New report finds more than 15.5 million Americans alive with a history of cancer in 2016, a number that is projected to reach more than 20 million by 2026.

Contact: David Sampson
American Cancer Society

Public Release: 2-Jun-2016
Cancer Cell
Rare eye disease that struck Oliver Sacks gives rise to new cancer treatment strategy
Eye cancer took the life of author and neurologist Oliver Sacks last year, bringing attention to the rare, hard-to-treat disease. Now, a team led by scientists at Huntsman Cancer Institute at the University of Utah report in Cancer Cell that a mutation that causes the cancer relies on a protein, ARF6, to distribute cancer-promoting signals. Further, treatment with a drug made against the protein inhibits eye tumors formation.
NIH/National Cancer Institute, National Institutes of Health, NIH/National Center for Advancing Translational Sciences

Contact: Amie Parker
University of Utah Health Sciences

Public Release: 2-Jun-2016
Cell Reports
Novel immunotherapy approach shows promise in blood cancers
Cancer researchers show that injecting substances that mimic tumor-cell DNA into the bloodstream can stimulate the STING pathway to provoke a life-extending immune response in mice with acute myeloid leukemia. This is the first demonstration that this approach could be effective in widely disseminated 'liquid' cancers, such as leukemia.
National Institutes of Health, University of Chicago Institute for Translational Medicine, Cancer Research Institute

Contact: John Easton
University of Chicago Medical Center

Public Release: 2-Jun-2016
Physical Biology
Prodding leukemia cells with nanoprobes could provide cancer clues
Giving blood cells a gentle squeeze can reveal a great deal about their health. To find out more, researchers in France have used a tiny force probe to compare the mechanical responses of healthy and cancerous hematopoietic cells (biological structures that help to renew blood in the body).

Contact: Alison Hadley
IOP Publishing

Public Release: 2-Jun-2016
Cell Chemical Biology
Novel compound shows promise against breast cancer
A promising new compound appears to impede a process that fuels breast cancer in mice, a discovery that could have implications in the treatment of a host of cancers.
National Institutes of Health, Pelotonia

Contact: Jesse Kwiek
Ohio State University

Public Release: 2-Jun-2016
JCI Insight
Detecting an early biomarker for pancreatic cancer in blood
In this issue of JCI Insight, a group of researchers led by Motoyuki Otsuka at the University of Tokyo describe a pilot study of a new method for detecting a pancreatic cancer biomarker in patient serum.
Ministry of Education, Culture, Sports, Science and Technology of Japan, Japan Prize Foundation, Tokyo Biomarker Innovation Research Association

Contact: Corinne Williams
JCI Journals

Public Release: 2-Jun-2016
Nucleic Acids Research
New free web service for deep study of cell functions
Scientists from Russia, US, Canada and Germany have developed a simple and effective web service that enables a better understanding of cell functions by identifying links between changes in metabolism and gene expression. New insights gained by means of the service can be applied to develop treatments for autoimmune diseases and cancer, since metabolic regulation plays a major role in such biological processes.
Government of Russian Federation, Washington University in St. Louis

Contact: Dmitry Malkov
ITMO University

Public Release: 2-Jun-2016
Journal of Leukocyte Biology
Finely tuned electrical fields give wound healing a jolt
A new research report appearing in the June 2016 issue of the Journal of Leukocyte Biology, opens up the possibility that small electrical currents might activate certain immune cells to jumpstart or speed wound healing. This discovery, made by a team of scientists from the United Kingdom, may be of particular interest to those with illnesses that may cause wounds to heal slowly or not at all.
Kidney Research UK, Institute of Medical Sciences University

Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Public Release: 2-Jun-2016
American Society of Clinical Oncology (ASCO) Annual Meeting
Lancet Oncology
Two-drug immunotherapy deemed safe for lung cancer patients, Moffitt study shows
A new Moffitt Cancer Center study being presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago and published in The Lancet Oncology shows that utilizing the immunotherapeutic agents nivolumab and ipilimumab could lead to more effective treatment options for SCLC patients who fail initial therapy.

Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 2-Jun-2016
Journal of Biological Chemistry
Olfactory receptor discovered in pigment cells of the skin
Pioneering researchers provided proof of an odorant receptor in pigment-producing cells in the human skin, so-called melanocytes. The team demonstrated that the violet-like Beta-Ionone odorant activates the receptor. The researchers identified the signalling pathways in detail that trigger an activation of the receptor. They consider their results a starting point for the therapy of malign melanoma.
German Research Foundation, Vogelsang Foundation

Contact: Hanns Hatt
Ruhr-University Bochum

Public Release: 2-Jun-2016
Nature Cell Biology
Mayo Clinic uncovers how 1 gene, protein suppresses tumor formation
Pten (short for phosphatase and tensin homolog) is a tumor suppressor that is defective in about 20-25 percent of all patients with cancers. Mayo Clinic researchers now have discovered that Pten safeguards against tumor formation by keeping chromosome numbers intact when a cell splits into two daughter cells.
National Institutes of Health

Contact: Bob Nellis
Mayo Clinic

Public Release: 2-Jun-2016
Journal of Investigative Dermatology
Topical skin creams effective to treat superficial basal cell carcinoma: New study
Basal cell carcinoma is one of the most common cancers and its incidence is increasing worldwide, putting a significant burden on health services. Topical treatments are available for superficial basal cell carcinoma (BCC) but there has a lack of long-term follow-up data to guide treatment decisions. A three-year randomized controlled clinical trial has found that two topical creams are effective in most primary, low-risk superficial BCC, comparing favorably with photodynamic therapy (PDT).

Contact: George Woodward

Public Release: 2-Jun-2016
American Society of Clinical Oncology (ASCO) Annual Meeting
International trial changing standard of care for advanced breast cancer
Surgery to remove the primary tumor in women diagnosed with stage IV breast cancer, followed by the standard combination of therapies, adds months to the patients' lives, compared with standard therapy alone, an international clinical trial led by a University of Pittsburgh Cancer Institute professor revealed.
Turkish Federation of Societies for Breast Diseases

Contact: Allison Hydzik
University of Pittsburgh Schools of the Health Sciences

Public Release: 2-Jun-2016
Cancer Research
Cancer cells become more aggressive from fat storage
It has been established that not all cancer cells are equally aggressive -- most can be neutralised with radiation and chemotherapy. Researchers at Lund University in Sweden have now discovered that some cancer cells can accumulate fat droplets, which appear to make them more aggressive and increase their ability to spread

Contact: Cecilia Schubert
Lund University

Public Release: 1-Jun-2016
Cancer Research
Pancreatic cancer: Aggressive behavior from the start
A particular microRNA suppresses the ability of cancer cells in the pancreas to invade surrounding tissue and spread metastases, researchers at the German Cancer Research Center and colleagues revealed in their latest study. In patients with pancreatic cancer, the researchers discovered that the lower the detected levels of this microRNA in the tumor are, the more unfavorably the disease progresses. Levels of this microRNA are often already reduced in chronic pancreatitis, which often precedes cancer.

Contact: Dr. Sibylle Kohlstädt
German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)

Public Release: 1-Jun-2016
Genome Medicine
Mount Sinai researchers report clinical utility of personalized medicine program for cancer patients
Integrated genomic profiles reveal significantly more actionable mutations than targeted cancer panels.

Contact: Glenn Farrell
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 1-Jun-2016
Clinical Cancer Research
Imaging biomarker distinguishes prostate cancer tumor grade
Physicians have long used magnetic resonance imaging (MRI) to detect cancer but results of a University of California San Diego School of Medicine study describe the potential use of restriction spectrum imaging (RSI) as an imaging biomarker that enhances the ability of MRI to differentiate aggressive prostate cancer from low-grade or benign tumors and guide treatment and biopsy.
US Department of Defense Prostate Cancer Research Program, American Cancer Society, UCSD Clinician Scientist Program, UCSD School of Medicine Microscopy Core, NIH/National Institutes of Neurological Disorders and Stroke

Contact: Yadira Galindo
University of California - San Diego

Public Release: 1-Jun-2016
American Journal of Preventive Medicine
In all US regions, broad support for increasing legal age of tobacco sales
Researchers from the University of North Carolina at Chapel Hill and East Carolina University report in the American Journal of Preventive Medicine that in all nine regions of the country, a majority of adults supported increasing the minimum legal age for tobacco product sales.
National Institutes of Health, NIH/National Cancer Institute, FDA/Center for Tobacco Products

Contact: Laura Oleniacz
University of North Carolina at Chapel Hill

Public Release: 31-May-2016
Ancient anti-inflammatory drug salicylic acid has cancer-fighting properties
Scientists from the Gladstone Institutes have identified a new pathway by which salicylic acid -- a key compound in the nonsteroidal anti-inflammatory drugs aspirin and diflunisal -- stops inflammation and tumor growth in cancer. Both salicylic acid and diflunisal suppress two key proteins that help control gene expression throughout the body. By inhibiting these proteins, the two drugs block the activation of other proteins involved in inflammation and cell growth, including one linked to leukemia.
University of California, San Francisco-Gladstone Institute of Virology and Immunology Center for AIDS Research, University of California, Berkeley Fogarty International AIDS Training Program, American Cancer Society, Larry L. Hillblom Foundation

Contact: Dana Smith
Gladstone Institutes

Public Release: 31-May-2016
Trends in Immunology
Cancer studies should include overweight, elderly mice
Saint Louis University's article in Trends in Immunology explains why using a more accurate animal model could improve cancer research.
NIH/National Institute of Allergy and Infectious Diseases, Cancer Research Institute, Siteman Cancer Center and The Foundation for Barnes-Jewish Hospital, Saint Louis University

Contact: Nancy Solomon
Saint Louis University

Public Release: 31-May-2016
Gynecologic Oncology
One in 5 women with ovarian cancer does not undergo surgery, Penn study reveals
Nearly 20 percent of women with ovarian cancer do not undergo surgery, despite it being a standard part of treatment recommendations. The findings, which suggest women may live four times longer with surgical treatment, were especially striking among older patients; researchers found that nearly half of women over 75 with stage III/IV cancer do not have surgery and roughly 25 percent receive no treatment at all. The study is published this month in the journal Gynecologic Oncology.

Contact: Katie Delach
University of Pennsylvania School of Medicine

Showing releases 226-250 out of 1373.

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