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Showing releases 26-50 out of 1373.

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Public Release: 25-Aug-2016
PLOS Computational Biology
Molecular flexibility shown to help pharmaceutical drugs bind to their targets
Scientists have discovered an alternative way to create a stronger binding between pharmaceutical drugs and the part of the body they are targeting -- a development that can be used to fight a variety of diseases, including breast cancer. The study published in PLOS Computational Biology shows that flexible molecules, instead of rigid ones, as previously thought, can bind more effectively to the proteins causing the disease.

Contact: Chia-en A. Chang
chiaenc@ucr.edu
PLOS

Public Release: 25-Aug-2016
Cell
Insights on lung micro-environment explain why cancer spreads to the lungs
The same mechanisms that that prevent people from having an inflammatory response to harmless environmental exposures in day-to-day life could also all allow rogue cancer cells to spread to the lungs, according to new research from The Ohio State University Comprehensive Cancer Center. Researchers have discovered and described how the lung's unique underlying immune environment enables cancer to readily spread to the organ.
NIH/National Cancer Institute, NIH/National Institute of Allergy and Infectious Diseases, Li Jinyuan, The Tiens Charitable Foundation, Milstein Family Foundation, Wellcome Trust, Royal Society, Biotechnology and Biological Sciences Research Council

Contact: Amanda Harper
amanda.harper2@osumc.edu
614-685-5420
Ohio State University Wexner Medical Center

Public Release: 25-Aug-2016
PLOS Computational Biology
Targeting low-oxygen patches inside lung cancer tumors could help prevent drug resistance
With the right treatment schedule, medications known as hypoxia-activated prodrugs (HAPs) could help prevent drug resistance in a subtype of lung cancer, according to a study published in PLOS Computational Biology.
National Science Foundation, National Institutes of Health

Contact: Jasmine Foo
jyfoo@math.umn.edu
508-471-0950
PLOS

Public Release: 25-Aug-2016
Cell
Stem cell propagation fuels cancer risk in different organs
Experiments reveal the crucial contribution of stem cells to the origins of cancer in different organs.

Contact: Frannie Marmorstein
frannie.marmorstein@stjude.org
St. Jude Children's Research Hospital

Public Release: 25-Aug-2016
JAMA Oncology
Study examines financial conflict of interests among NCCN guideline authors
A new study published online by JAMA Oncology quantifies industry financial conflicts of interest (FCOIs) among authors of National Comprehensive Cancer Network (NCCN) guidelines, work that influences practice and defines drugs reimbursable by Medicare.

Contact: Laura Oleniacz
laura_oleniacz@med.unc.edu
919-445-4219
The JAMA Network Journals

Public Release: 25-Aug-2016
Cell Stem Cell
Study shows protein complex essential to creating healthy blood cells
A group of proteins best known for helping to activate all mammalian genes has been found to play a particularly commanding role in the natural development of specialized stem cells into healthy blood cells, a process known as hematopoiesis.

Contact: David March
david.march@nyumc.org
212-404-3528
NYU Langone Medical Center / New York University School of Medicine

Public Release: 25-Aug-2016
Cell
Oxygen can impair cancer immunotherapy in mice
Researchers have identified a mechanism in mice by which anticancer immune responses are inhibited within the lungs, a common site of metastasis for many cancers.
NIH/National Cancer Institute, NIH/National Institute of Allergy and Infectious Disease

Contact: NCI Press Office
ncipressofficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute

Public Release: 24-Aug-2016
Nature
Breast cancer cells found to switch molecular characteristics
A study led by Massachusetts General Hospital investigators reveals how spontaneous changes in the molecular characteristics of tumors can lead to tumors with a mixed population of cells requiring treatment with several types of therapeutic drugs.
National Institutes of Health, Howard Hughes Medical Institute, Breast Cancer Research Foundation, National Foundation for Cancer Research, Wellcome Trust, Susan G. Komen Foundation

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital

Public Release: 24-Aug-2016
New England Journal of Medicine
Excess weight linked to 8 more cancer types
There's yet another reason to maintain a healthy weight as we age. An international team of researchers has identified eight additional types of cancer linked to excess weight and obesity: stomach, liver, gall bladder, pancreas, ovary, meningioma (a type of brain tumor), thyroid cancer and the blood cancer multiple myeloma.

Contact: Judy Martin Finch
martinju@wustl.edu
314-286-0105
Washington University School of Medicine

Public Release: 24-Aug-2016
Clinical Cancer Research
UCF technology for killing metastatic breast cancer cells discovered, licensed
A University of Central Florida cancer researcher has discovered a way to kill spreading breast cancer cells and her new technology has generated a licensing agreement that will accelerate the therapy's path to clinical trials. Metastatic cancer cells that spread from the original tumor to the brain, lungs and bones are the leading cause of death for most cancer patients, said Annette Khaled, the researcher who made the discovery. Her work is featured in the September edition of Clinical Cancer Research.
National Institutes of Health, Breast Cancer Research Foundation

Contact: Wendy Sarubbi
wendy.sarubbi@ucf.edu
407-266-1418
University of Central Florida

Public Release: 24-Aug-2016
Nature Nanotechnology
50 years after the release of the film 'Fantastic Voyage,' science upstages fiction
Fifty years to the day after the film 'Fantastic Voyage' was first shown in theaters, the Polytechnique Montréal Nanorobotics Laboratory is unveiling a unique medical interventional infrastructure devoted to the fight against cancer. The outcome of 15 years of research conducted by Professor Sylvain Martel and his team, it enables microscopic nanorobotic agents to be guided through the vascular systems of living bodies, delivering drugs to targeted areas.

Contact: Annie Touchette
annie.touchette@polymtl.ca
514-231-8133
Polytechnique Montréal

Public Release: 24-Aug-2016
Nature Communications
Fateful evolution: New study improves accuracy of cancer diagnosis
In a new study, Carlo Maley, a researcher at Arizona State University's Biodesign Institute, uses evolutionary theory to make predictions about which BE patients will go on to develop cancer. The results, which appear in the current issue of the journal Nature Communications, point the way toward more accurate medical assessments for patients with BE and the development of early-warning beacons of disease known as biomarkers.

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-258-8972
Arizona State University

Public Release: 24-Aug-2016
Journal of Thoracic Oncology
Lymph node stage may have clinical significance among NSCLC patients with stage IV M1a
Analysis of a large non-small cell lung cancer (NSCLC) patient cohort with stage IV M1a disease identified lymph node staging as having clinical significance and an impact on prognosis.

Contact: Becky Bunn
becky.bunn@iaslc.org
720-254-9509
International Association for the Study of Lung Cancer

Public Release: 24-Aug-2016
Cancer Research
Smokers with newly discovered genetic markers have higher lung cancer risk
University of Hawai'i Cancer Center researchers discovered new genetic markers associated with a fast rate of nicotine metabolism, which potentially leads smokers to smoke more, thereby, increasing their risk for lung cancer.

Contact: Nana Ohkawa
nohkawa@cc.hawaii.edu
808-564-5911
University of Hawaii Cancer Center

Public Release: 24-Aug-2016
Proceedings of the National Academy of Sciences
Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer
Cancer researchers have long observed the value of treating patients with combinations of anti-cancer drugs that work better than single drug treatments. Now, in a new study using laboratory-grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining anti-cancer drugs, including one in a nanoparticle format developed at Johns Hopkins, that specifically target those pathways.
NIH/National Cancer Institute, NIH/National Institute on Drug Abuse, NIH/National Institute of Mental Health, NIH/National Center for Advancing translational Sciences

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 23-Aug-2016
Scientific Reports
Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells
A discovery in the field of biomaterials may open new frontiers in stem and cancer cell manipulation and associated advanced therapy development. Novel scaffolds are shown enabling cells to behave in a different but controlled way in vitro due to the presence of aligned, self-assembled ceramic nanofibers of an ultra-high anisotropy ratio augmented into graphene shells.

Contact: Michael Gasik
michael.gasik@aalto.fi
358-505-609-511
Aalto University

Public Release: 23-Aug-2016
Science Signaling
New study provides important insight into how tumors metastasize
Research has shown that the growth of cancerous tumors is affected by Transforming growth factor (TGFbeta) in the body's cells; TGFbeta both suppresses and stimulates tumor development, but it has not been understood how this happens. A new study published in the journal Science Signaling today reveals important details behind this process.

Contact: Carl-Henrik Heldin
c-h.heldin@licr.uu.se
46-707-342-547
Uppsala University

Public Release: 23-Aug-2016
ACS Synthetic Biology
Analog DNA circuit does math in a test tube
Duke University researchers have created strands of synthetic DNA that, when mixed together in a test tube in the right concentrations, form an analog circuit that can add, subtract and multiply as the molecules form and break bonds. While most DNA circuits are digital, their device performs calculations in an analog fashion by measuring the varying concentrations of specific DNA molecules directly, without requiring special circuitry to convert them to zeroes and ones first.
National Science Foundation

Contact: Robin Ann Smith
ras10@duke.edu
919-681-8057
Duke University

Public Release: 23-Aug-2016
Genes and Cancer
Melatonin boost a key to fighting breast cancer
Melatonin, a hormone produced in the human brain, appears to suppress the growth of breast cancer tumors. Researchers at Michigan State University published this finding in the current issue of Genes and Cancer. While treatments based on this key discovery are still years away, the results give scientists a key foundation on which to build future research.

Contact: Layne Cameron
layne.cameron@cabs.msu.edu
517-353-8819
Michigan State University

Public Release: 23-Aug-2016
eLife
Brief rapamycin therapy in middle-aged mice extends lives
In mice, the drug rapamycin is known to extend lives and delay some age-related problems. Questions remain about about how it promotes healthy aging, when, how much and how long to administer rapamycin, and how to avoid serious side effects. A new study showed brief therapy during middle age with rapamycin dramatically extended mouse lives. Findings revealed the need to further examine how gender and dose influence side effects and the drug's impact on susceptibility to and protection from different types of cancer.
NIH/National Institute on Aging, Japan Society for the Promotion of Science, Uehara Memorial Foundation

Contact: Leila Gray
leilag@uw.edu
206-685-0381
University of Washington Health Sciences/UW Medicine

Public Release: 22-Aug-2016
Water Resources Research
Urban pumping raises arsenic risk in Southeast Asia
Large-scale groundwater pumping is opening doors for dangerously high levels of arsenic to enter some of Southeast Asia's aquifers, with water now seeping in through riverbeds with arsenic concentrations more than 100 times the limits of safety, according to a new study from scientists at Columbia University's Lamont-Doherty Earth Observatory, MIT, and Hanoi University of Science.

Contact: Kevin Krajick
kkrajick@ei.columbia.edu
212-854-9729
The Earth Institute at Columbia University

Public Release: 22-Aug-2016
Annals of Oncology
Expecting the worst increases side-effects in breast cancer patients on hormone therapies
A study of women receiving hormone therapies such as tamoxifen as part of their treatment for breast cancer has found that the number and seriousness of side effects they experienced were influenced by their expectations. The study, published in Annals of Oncology, found that women who had higher expectations of suffering more and worse side-effects before their treatment began did, in fact, experience more after two years of adjuvant hormone therapy.
German Research Foundation, Philipps-University of Marburg

Contact: Emma Mason
wordmason@mac.com
European Society for Medical Oncology

Public Release: 22-Aug-2016
Nature Cell Biology
Tel Aviv University research reveals how melanoma spreads to other organs in the body
In a landmark discovery, researchers at Tel Aviv University have unraveled the metastatic mechanism of melanoma, the most aggressive of all skin cancers. Their work may lead to a cure for the deadly disease.

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University

Public Release: 22-Aug-2016
Proceedings of the National Academy of Sciences
Novel MRI technique distinguishes healthy prostate tissue from cancer using zinc
A novel MRI method that detects low levels of zinc ion can help distinguish healthy prostate tissue from cancer, UT Southwestern Medical Center radiologists have determined.
National Institutes of Health, NIH/National Cancer Institute, Harold C. Simmons Comprehensive Cancer Center, American Diabetes Association, Robert A. Welch Foundation

Contact: Lori Sudeen Soderbergh
lori.soderbergh@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 22-Aug-2016
Clinical Gastroenterology and Hepatology
AGA answers call for quality colorectal cancer patient info
Patients depend on the Internet for health information, but when it comes to colorectal cancer, currently available resources are not meeting their needs. These findings were recently published in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association.

Contact: Rachel Shubert
media@gastro.org
301-272-1603
American Gastroenterological Association

Showing releases 26-50 out of 1373.

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