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Showing releases 251-275 out of 1234.

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Public Release: 18-Mar-2014
PLOS ONE
Exposure to snuff smoke in non-smokers fell by 90 percent after the tobacco control laws
The study evaluated a biomarker of exposure to snuff smoke in non-smokers and also their perception before and after the entry into force of the two laws. The work done by the Tobacco Control Unit of the ICO-IDIBELL has been published in the journal PLOS ONE.

Contact: Arantxa Mena
amena@idibell.cat
34-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 18-Mar-2014
Cancer Epidemiology, Biomarkers & Prevention
Early detection of childhood eye cancer doesn't always improve survival, prevent eye loss
For the most common form of childhood eye cancer, unilateral retinoblastoma, shortening the time from the first appearance of symptoms to diagnosis of disease has no bearing on survival or stage of the disease, according to a study by researchers at Columbia University Mailman School of Public Health in partnership with the Hospital Infantil de Mexico. The results appear online in the journal Cancer Epidemiology, Biomarkers & Prevention.
National Institutes of Health

Contact: Timothy S. Paul
tp2111@columbia.edu
212-305-2676
Columbia University's Mailman School of Public Health

Public Release: 18-Mar-2014
Nature Methods
Major breakthrough in developing new cancer drugs: Capturing leukemic stem cells
The Institute for Research in Immunology and Cancer at the University of Montreal, in collaboration with the Maisonneuve-Rosemont Hospital's Quebec Leukemia Cell Bank, recently achieved a significant breakthrough thanks to the laboratory growth of leukemic stem cells, which will speed up the development of new cancer drugs.

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-566-3813
University of Montreal

Public Release: 18-Mar-2014
Proceedings of the National Academy of Sciences
Moffitt researchers discover new mechanism allowing tumor cells to escape immune surve
The immune system plays a pivotal role in targeting cancer cells for destruction. However, tumor cells are smart and have developed ways to avoid immune detection. A collaborative team of researchers at Moffitt Cancer Center recently discovered a novel mechanism that lung cancer cells use to block detection by a type of immune cell called a natural killer cell.
National Institutes of Health

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 18-Mar-2014
Radiology
Using big data to identify triple-negative breast, oropharyngeal, and lung cancers
Researchers at Case Western Reserve University and colleagues used 'big data' analytics to accurately predict if a patient is suffering from aggressive or more treatable forms of breast cancer and a type of head and neck cancer. They are beginning a similar study on lung cancers. All efforts are to provide patients with earlier and more accurate detection, enabling them to choose the most suitable treatments.
National Institutes of Health

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University

Public Release: 18-Mar-2014
PLOS ONE
TGen-led study spotlights dog DNA role in developing new therapies for human cancers
Using genomic analysis to study cancer in dogs can help develop new therapies for humans with cancer, according to a proof-of-concept study led by the National Cancer Institute and the Translational Genomics Research Institute.
National Institutes of Health

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute

Public Release: 17-Mar-2014
Journal of Clinical Oncology
Primary androgen deprivation therapy ineffective for most men with early prostate cancer
A study of more than 15,000 men with early stage prostate cancer finds that those who received androgen deprivation as their primary treatment instead of surgery or radiation did not live any longer than those who received no treatment.
NIH/National Cancer Institute

Contact: Karen Teber
km463@georgetown.edu
Georgetown University Medical Center

Public Release: 17-Mar-2014
Proceedings of the National Academy of Sciences
Bacterial reporters that get the scoop
A new engineered strain of E. coli bacteria non-destructively detected and recorded an environmental signal in the mouse gut, and remembered what it 'saw.' The advance could lead to a radically new screening tool for human gut health.
Defense Advanced Research Projects Agency, Harvard's Wyss Institute

Contact: Kristen Kusek
kristen.kusek@wyss.harvard.edu
617-432-8266
Wyss Institute for Biologically Inspired Engineering at Harvard

Public Release: 17-Mar-2014
Journal of Cell Biology
Study finds that fast-moving cells in the human immune system walk in a stepwise manner
A team of biologists and engineers at UC San Diego applied advanced mathematical tools to answer a basic question in cell biology about how cells move and discovered that the mechanism looks very similar to walking. Their discovery, published March 17 in the Journal of Cell Biology, is an important advance toward developing new pharmacological strategies to treat chronic inflammatory diseases.
National Institutes of Health

Contact: Catherine Hockmuth
chockmuth@ucsd.edu
858-822-1359
University of California - San Diego

Public Release: 17-Mar-2014
CA: A Cancer Journal for Clinicians
Study: Colon cancer incidence rates decreasing steeply in older Americans
Colon cancer incidence rates have dropped 30 percent in the US in the last 10 years among adults 50 and older due to the widespread uptake of colonoscopy, with the largest decrease in people over age 65.
American Cancer Society

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society

Public Release: 17-Mar-2014
Biochimica et Biophysica Acta-General Subjects
New hope for early detection of stomach cancer
University of Adelaide research has provided new hope for the early detection of stomach cancer with the identification of four new biomarkers in the blood of human cancer patients.

Contact: Peter Hoffmann
Peter.Hoffmann@adelaide.edu.au
61-043-407-9108
University of Adelaide

Public Release: 17-Mar-2014
Journal of Clinical Oncology
Health gap between adult survivors of childhood cancer and siblings widens with age
Adult survivors of childhood cancer face significant health problems as they age and are five times more likely than their siblings to develop new cancers, heart and other serious health conditions beyond the age of 35, according to the latest findings from the world's largest study of childhood cancer survivors.
NIH/National Cancer Institute, ALSAC

Contact: Summer Freeman
media@stjude.org
901-595-3061
St. Jude Children's Research Hospital

Public Release: 17-Mar-2014
PLOS ONE
Archaeologists discover the earliest complete example of a human with cancer
Archaeologists have found the oldest complete example in the world of a human with metastatic cancer in a 3,000-year-old skeleton.
Leverhulme Trust, Institute of Bioarchaeology Amara West Field School

Contact: Dionne Hamil
dionne.hamil@durham.ac.uk
01-913-346-078
Durham University

Public Release: 16-Mar-2014
American Chemical Society 247th National Meeting & Exposition
Major 'third-hand smoke' compound causes DNA damage -- and potentially cancer
Leftover cigarette smoke that clings to walls and furniture is a smelly nuisance, but now research suggests that it could pose a far more serious threat, especially to young children who put toys and other smoke-affected items into their mouths. Scientists reported today at the 247th National Meeting & Exposition of the American Chemical Society that one of the tobacco-specific nitrosamines newly formed in 'third-hand smoke' damages DNA and could potentially cause cancer.

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

Public Release: 16-Mar-2014
Nature
How diabetes drugs may work against cancer
Scientists at Whitehead Institute have pinpointed a major mitochondrial pathway that imbues cancer cells with the ability to survive in low-glucose environments. By identifying cancer cells with defects in this pathway or with impaired glucose utilization, the scientists can predict which tumors will be sensitive to these anti-diabetic drugs known to inhibit this pathway.
Leukemia and Lymphoma Society, Jane Coffin Childs Fund, Council of Higher Education Turkey, Karadeni

Contact: Nicole Rura
rura@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research

Public Release: 16-Mar-2014
Nature Genetics
Cancer therapy may be too targeted
Targeted therapies seem to be the future of cancer treatment, but can they be too narrowly focused? In a study published in Nature Genetics, scientists have found that for a rare cancer of the blood vessel where several mutations can underlie the disease, many different parts of the pathway can be disrupted. For patients with multiple underlying mutations, previously developed therapies that focus on targeting a single component in the pathway will be ineffective.
Wellcome Trust

Contact: Mary Clarke
press.office@sanger.ac.uk
44-012-234-95328
Wellcome Trust Sanger Institute

Public Release: 14-Mar-2014
Clinical Cancer Research
Dartmouth researchers develop new approach to chronic lymphocytic leukemia treatment
Dartmouth researchers have developed a novel and unique approach to treating Chronic Lymphocytic Leukemia (CLL), a form of blood cancer that often requires repeated chemotherapy treatments to which it grows resistant. The researchers modeled the lymph node microenvironment where CLL cells are found in the laboratory. They were able to disrupt the activity of a pathway that ensures the survival and resistance of the CLL cells in such microenvironments.
NIH/National Cancer Institute, Leukemia & Lymphoma Society

Contact: Robin Dutcher
robin.Dutcher@hitchcock.org
603-653-9056
The Geisel School of Medicine at Dartmouth

Public Release: 14-Mar-2014
Annals of Surgical Oncology
New findings show link between diabetes and pancreatic cancer
Researchers from the University of Melbourne have shown that there is an association between pancreatic cancer and diabetes.

Contact: Anne Rahilly
arahilly@unimelb.edu.au
61-390-355-380
University of Melbourne

Public Release: 14-Mar-2014
Physical Chemistry Chemical Physics
Big data tackles tiny molecular machines
Rice University researchers combine genetic and structural data to begin to solve one of the most compelling mysteries in biology: how proteins perform the regulatory mechanisms in cells upon which life depends.
Welch Foundation, National Science Foundation, Cancer Prevention and Research Institute of Texas

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University

Public Release: 14-Mar-2014
eLife
In the lab, scientists coax E. coli to resist radiation damage
Capitalizing on the ability of an organism to evolve in response to punishment from a hostile environment, scientists have coaxed the model bacterium Escherichia coli to dramatically resist ionizing radiation and, in the process, reveal the genetic mechanisms that make the feat possible.
National Institutes of Health, US Department of Energy

Contact: Michael Cox
mcox@wisc.edu
608-262-1181
University of Wisconsin-Madison

Public Release: 13-Mar-2014
67th SSO Annual Cancer Symposium
Pancreatic cancer surgery findings presented at SSO
Despite the benefits of surgery for early stage pancreatic cancer, it remains under-utilized for patients with this deadly disease, according to a new national analysis of trends and outcomes. Physician-scientists at University Hospitals Case Medical Center and Case Western Reserve University School of Medicine presented their findings and strategies to increase rates at the Society of Surgical Oncology Cancer Symposium in Phoenix.

Contact: Alicia Reale
alicia.reale@uhhospitals.org
University Hospitals Case Medical Center

Public Release: 13-Mar-2014
Journal of Cell Biology
'Velcro protein' found to play surprising role in cell migration
Studying epithelial cells, the cell type that most commonly turns cancerous, Johns Hopkins researchers have identified a protein that causes cells to release from their neighbors and migrate away from healthy mammary, or breast, tissue in mice. They also found that deletion of a cellular 'Velcro protein' does not cause the single-celled migration expected. Their results, they say, help clarify the molecular changes required for cancer cells to metastasize.
American Cancer Society, NIH/National Cancer Institute, NIH/National Institute of General Medical Sciences, NIH/National Center for Research Resources, Safeway, Avon, Hay Graduate Award, Kleberg Foundation

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine

Public Release: 13-Mar-2014
Frontiers in Oncology
Study proposes new ovarian cancer targets
Proteins called TAFs were once thought to be generic cogs in the machinery of gene expression, but in a new study Brown University scientists propose that they may be important suspects in the progression of ovarian cancer that should not continue to be overlooked.
National Institutes of Health, American Cancer Society, Canadian Institutes of Health

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

Public Release: 13-Mar-2014
Cell Reports
A gene family that suppresses prostate cancer
Cornell University researchers report they have discovered direct genetic evidence that a family of genes, called microRNA-34, are bona fide tumor suppressors.
National Institutes of Health, New York State Stem Cell Science, Deutsche Krebshilfe

Contact: Joe Schwartz
Joe.Schwartz@cornell.edu
607-254-6235
Cornell University

Public Release: 13-Mar-2014
Journal of Urology
Prostate specific antigen screening declines after 2012 USPSTF recommendations
Researchers at Case Western Reserve University and University Hospitals Case Medical Center have assessed the impact of the 2012 US Preventive Services Task Force recommendations against routine prostate specific antigen (PSA) cancer screenings, which cited evidence that the risks of screening outweigh the benefits. Results of the current study indicate that the USPSTF recommendations have resulted in a decrease in the number of PSA screenings ordered by doctors, with the greatest decline seen among urologists.

Contact: Linda Gruner
jumedia@elsevier.com
212-633-3923
Elsevier Health Sciences

Showing releases 251-275 out of 1234.

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