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Showing releases 251-275 out of 1234.

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Public Release: 20-Jul-2014
Nature
Scientists map one of most important proteins in life -- and cancer
Scientists reveal the structure of one of the most important and complicated proteins in cell division - a fundamental process in life and the development of cancer -- in research published in Nature today.
Cancer Research UK

Contact: Graham Shaw
graham.shaw@icr.ac.uk
020-715-35380
Cancer Research UK

Public Release: 18-Jul-2014
Journal of the National Cancer Institute
A negative HPV test may predict lower cervical cancer risk than a negative Pap
In the US, cotesting for human papilloma virus and Pap testing for cervical cancer every 5 years for women aged 30-65 years is now recommended. However, human papilloma virus testing alone may provide better reassurance against cervical cancer than Pap testing alone and similar reassurance to cotesting, according to a study published July 18 in the Journal of the National Cancer Institute.

Contact: Zachary Rathner
919-677-2697
Oxford University Press USA

Public Release: 18-Jul-2014
Cell Reports
Bowel cancer breakthrough may benefit thousands of patients
Researchers at Queen's University have made a significant breakthrough that may benefit patients with bowel cancer. Dr Sandra van Schaeybroeck and her team have discovered how two genes cause bowel cancer cells to become resistant to treatments used against the disease. The research, which was funded by Cancer Research UK, was published this month in the prestigious international journal Cell Reports.

Contact: Claire O'Callaghan
c.ocallaghan@qub.ac.uk
Queen's University Belfast

Public Release: 18-Jul-2014
Clinical Cancer Research
Yale researchers identify targets for immunotherapy in early-stage breast cancer
Yale Cancer Center researchers used a new molecular analysis tool to detect the level of an important target for immunotherapy in early-stage breast cancers. The diagnostic test, using RNAScope, measures the amount of PD-L1 mRNA in cancer tissues and is devoid of many of the technical issues that plague antibody-based detection methods that have yielded conflicting results in the past. PD-L1 is the target of several novel immune stimulatory therapies in clinical trials.
Breast Cancer Research Foundation, Novartis/Genoptix

Contact: Vicky Agnew
vicky.agnew@yale.edu
203-785-7001
Yale University

Public Release: 17-Jul-2014
Physical Biology
Physicists reveal random nature of metastasis
The spreading of a cancerous tumour from one part of the body to another may occur through pure chance instead of key genetic mutations, a new study has shown.

Contact: Michael Bishop
michael.bishop@iop.org
01-179-301-032
Institute of Physics

Public Release: 17-Jul-2014
Cell
Faithful cell division requires tightly controlled protein placement at the centromeres
The protein CENP-A, which is integrated into human DNA at the centromere on each chromosome, has a vital role in cell division. Work from Whitehead Institute Member Iain Cheeseman's lab describes how the vital and tightly controlled replenishment of CENP-A progresses.
Leukemia and Lymphoma Society, National Institutes of Health, American Cancer Society

Contact: Nicole Giese Rura
rura@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research

Public Release: 17-Jul-2014
Cell Metabolism
One third of cancer patients are killed by a 'fat-burning' process termed 'cachexia'
Erwin Wagner's team at the Spanish National Cancer Research Center has uncovered that cachexia is triggered by a process thoroughly studied in the fight against obesity: the conversion of white fat into brown fat. The researchers also argue that reducing the transformation of fat tissue can improve the symptoms of cachexia. This approach can be used to develop novel therapeutic strategies to treat cancer. These results are published in the journal 'Cell Metabolism'.

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 17-Jul-2014
Cell
Gut microbes turn carbs into colorectal cancer
Colorectal cancer has been linked to carbohydrate-rich western diets, but the underlying mechanisms have been unclear. A study published in Cell shows that gut microbes metabolize carbohydrates in the diet, causing intestinal cells to proliferate and form tumors in mice that are genetically predisposed to colorectal cancer. Treatment with antibiotics or a low-carbohydrate diet significantly reduced tumors in these mice, suggesting that these easy interventions could prevent a common type of colorectal cancer in humans.

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press

Public Release: 17-Jul-2014
Cell Metabolism
Brown fat found to be at the root of cancer-related wasting syndrome
Many patients with advanced stages of cancer, AIDS, tuberculosis, and other diseases die from a condition called cachexia, which is characterized as a 'wasting' syndrome that causes extreme thinness with muscle weakness. Cachexia is the direct cause of roughly 20 percent of deaths in cancer patients. While boosting food intake doesn't help, and no effective therapies are available, new research points to a promising strategy that may stimulate weight gain and muscle strength.

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press

Public Release: 17-Jul-2014
Cancer Cell
Tak Mak study in Cancer Cell maps decade of discovery to potential anticancer agent
The journal Cancer Cell today published research led by Dr. Tak Mak mapping the path of discovery to developing a potential anticancer agent.
The Princess Margaret Cancer Foundation, Canadian Institutes of Health Research, Genome Canada

Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network

Public Release: 17-Jul-2014
Cell Reports
CNIO researchers discover a gene that links stem cells, aging and cancer
An organism is healthy thanks to a good maintenance system: the normal functioning of organs and environmental exposure cause damage to tissues, which need to be continuously repaired. This process is not yet well understood, but it is known that stem cells in the organs play a key role. Researchers from the Spanish National Cancer Research Centre have discovered one of the key genes that make up the maintenance mechanism for tissues.

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 17-Jul-2014
Biochemical and Biophysical Research Communications
Lipoic acid helps restore, synchronize the 'biological clock'
Researchers have discovered a possible explanation for the surprisingly large range of biological effects that are linked to a micronutrient called lipoic acid: It appears to reset and synchronize circadian rhythms, or the 'biological clock' found in most life forms.
National Institutes of Health

Contact: Tory Hagen
tory.hagen@oregonstate.edu
541-737-5083
Oregon State University

Public Release: 17-Jul-2014
Molecular Cell
New gene discovered that stops the spread of deadly cancer
Scientists at the Salk Institute have identified a gene responsible for stopping the movement of cancer from the lungs to other parts of the body, indicating a new way to fight one of the world's deadliest cancers.

Contact: Kristina Grifantini
press@salk.edu
858-453-4100 x1226
Salk Institute

Public Release: 17-Jul-2014
Proceedings of the National Academy of Sciences
University of Houston researchers create new method to draw molecules from live cells
University of Houston researchers have devised a new method for extracting molecules from live cells without disrupting cell development, work that could provide new avenues for the diagnosis of cancer and other diseases. The researchers used magnetized carbon nanotubes to extract biomolecules from live cells, allowing them to retrieve molecular information without killing the individual cells.

Contact: Jeannie Kever
jekever@uh.edu
713-743-0778
University of Houston

Public Release: 16-Jul-2014
Journal of the National Cancer Institute
Screening costs increased in older women without changing detection rates of ESBC
Medicare spending on breast cancer screening increased substantially between 2001 and 2009 but the detection rates of early stage tumors were unchanged, according to a new study published July 16 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
919-677-2697
Oxford University Press USA

Public Release: 16-Jul-2014
Journal of the National Cancer Institute
Marginal life expectancy benefit from contralateral prophylactic mastectomy
The choice of contralateral prophylactic mastectomy by women with breast cancer diagnosed in one breast has recently increased in the US but may confer only a marginal life expectancy benefit depending on the type and stage of cancer, according to a study published July 16 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
Zachary.Rathner@oup.com
919-677-2697
Oxford University Press USA

Public Release: 16-Jul-2014
Nicotine and Tobacco Research
Study: Smoking may contribute to suicide risk
Cigarette smokers are more likely to commit suicide than people who don't smoke, a relationship that has been attributed to the fact that numerous people with psychiatric disorders, who have higher suicide rates, also tend to smoke. But a new study by researchers at Washington University School of Medicine in St. Louis finds that smoking itself may increase suicide risk and that policies to limit smoking reduce suicide rates.
American Foundation for Suicide Prevention, NIH/National Institute on Drug Abuse, NIH/National Cancer Institute, American Cancer Society.

Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine

Public Release: 16-Jul-2014
Angewandte Chemie
Self-assembling nanoparticle could improve MRI scanning for cancer diagnosis
Scientists have designed a new self-assembling nanoparticle that targets tumours, to help doctors diagnose cancer earlier.
Cancer Research UK, Engineering and Physical Sciences Research Council, Medical Research Council, Department of Health

Contact: Gail Wilson
gail.wilson@imperial.ac.uk
44-020-759-46702
Imperial College London

Public Release: 16-Jul-2014
New England Journal of Medicine
Promising medication counteracts constipation caused by opioid painkillers
Opioids -- strong morphine-based painkillers -- are widely prescribed to patients experiencing chronic severe pain. While these drugs are very effective for treating and managing pain, they have one particularly bothersome side effect: constipation. A new drug, called naloxegol, could bring relief. In stage 3 trials reported in the New England Journal of Medicine, KU Leuven and international researchers provide new evidence that the drug relieves constipation without dulling opioids' pain-relieving effects.

Contact: Jan Tack
jan.tack@med.kuleuven.be
321-634-4225
KU Leuven

Public Release: 16-Jul-2014
European Urology
Study: Robot-assisted surgery for prostate cancer controls the disease for 10 years
Robot-assisted surgery to remove cancerous prostate glands is effective in controlling the disease for 10 years, according to a new study led by researchers at Henry Ford Hospital. The study also suggested that traditional methods of measuring the severity and possible spread of the cancer together with molecular techniques might, with further research, help to create personalized, cost-effective treatment regimens for prostate cancer patients who undergo the surgical procedure.
Vattikuti Urology Institute

Contact: Dwight Angell
dwight.angell@hfhs.org
313-876-8709
Henry Ford Health System

Public Release: 15-Jul-2014
American Journal of Preventive Medicine
4 lessons for effective, efficient research in health care settings
University of Colorado Cancer Center study shows that by taking into account the real-world constraints of the systems in which providers deliver care and patients receive it, researchers can help speed results, cut costs, and increase chances that recommendations from their findings will be implemented.

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

Public Release: 15-Jul-2014
Clinical Cancer Research
New skin gel fights breast cancer without blood clot risk
A gel form of tamoxifen applied to the breasts of women with noninvasive breast cancer reduced the growth of cancer cells equally to the oral drug but with fewer side effects that deter some women from taking it. The gel is intended to minimize blood clots and uterine cancer risk. Tamoxifen is used for breast cancer prevention and for cancer treatment.
National Cancer Institute

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University

Public Release: 15-Jul-2014
Molecular Cell
New UK study helps scientists understand melanoma development
A new study by University of Kentucky researchers shows how a genetic defect in a specific hormonal pathway may make people more susceptible to developing melanoma, the deadliest type of skin cancer.
National Institutes of Health, Drury Pediatric Research Endowed Chair Fund, Wendy Will Case Cancer Research Fund, Markey Cancer Foundation, Children's Miracle Network, Jennifer and David Dickens Melanoma Research Foundation

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky

Public Release: 15-Jul-2014
Nature Reviews Urology
Prostate cancer in young men -- More frequent and more aggressive?
The number of younger men diagnosed with prostate cancer has increased nearly 6-fold in the last 20 years, and the disease is more likely to be aggressive in these younger men, according to a new analysis from researchers at the University of Michigan Comprehensive Cancer Center.
National Cancer Institute

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 15-Jul-2014
Interface Focus
Game theory model reveals vulnerable moments for cancer cells' energy production
Cancer's no game, but researchers at Johns Hopkins are borrowing ideas from evolutionary game theory to learn how cells cooperate within a tumor to gather energy. Their experiments, they say, could identify the ideal time to disrupt metastatic cancer cell cooperation and make a tumor more vulnerable to anti-cancer drugs.
NIH/National Cancer Institute

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Showing releases 251-275 out of 1234.

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