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Showing releases 251-275 out of 1359.

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Public Release: 29-Apr-2015
Journal of National Cancer Institute
Danish discovery may change cancer treatment
Danish researchers from the University of Copenhagen and Herlev Hospital have made a discovery that may change the principles for treating certain types of cancer.

Contact: Stig Bojesen
stig.egil.bojesen@regionh.dk
45-61-79-71-51
University of Copenhagen - The Faculty of Health and Medical Sciences

Public Release: 29-Apr-2015
Nature
Combined chemotherapy and immunotherapy shows promise for advanced prostate cancers
Researchers at the University of California, San Diego School of Medicine report that blocking or removing immune-suppressing cells allows a special type of chemotherapy -- and the immune cells it activates -- to destroy prostate tumors. This novel combination therapy, termed chemoimmunotherapy, achieved near complete remission in mouse models of advanced prostate cancer. The study is published April 29 in Nature.
National Institutes of Health, California Institute for Regenerative Medicine, German Research Foundation, Genome Research-Austria and Cancer Research Institute

Contact: Heather Buschman
hbuschman@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 29-Apr-2015
New England Journal of Medicine
Rociletinib shows promising activity against treatment-resistant EGFR-mutated lung cancer
A new targeted therapy drug against EGFR-mutation driven lung tumors that have become resistant to current therapies shows activity against the most common resistance mutation, significantly improving outcomes for patients. Results of the phase I/II clinical trial of rociletinib (previously known as CO-1686) are being published in the April 30 New England Journal of Medicine.
Clovis Oncology

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital

Public Release: 29-Apr-2015
CNS Oncology
Brain tumor patients should be screened for depression
Because depression in brain cancer patients is a common but often overlooked condition, oncologists should regularly screen tumor patients for depression, according to an article in the current issue of CNS Oncology. The journal is published by Future Medicine, an imprint of Future Science Group.

Contact: Leela Ripton
l.ripton@future-science-group.com
44-208-371-6090
Future Science Group

Public Release: 29-Apr-2015
New England Journal of Medicine
NEJM reports promising results of phase 1/2 trial of rociletinib in EGFR lung cancer
The New England Journal of Medicine reports results of a multi-center phase I/II study of the investigational anti-cancer agent rociletinib in patients with EGFR-mutant non-small cell lung cancer that had progressed after previous treatment with EGFR inhibitors. Responses were seen in 59 percent of evaluable patients with the T790M mutation. In this same population, median progression-free survival at the time of analysis was 13.1 months.

Contact: Garth Sundem
garth.sundem@ucdenver.edu
805-559-2023
University of Colorado Denver

Public Release: 29-Apr-2015
Science Translational Medicine
New therapy from naïve cells attacks high-risk viruses in cord blood transplant patients
Researchers in the Center for Cell and Gene Therapy at Baylor College of Medicine, Houston Methodist and the Texas Children's Hospital have expanded the use of virus-specific cell therapy in cord blood transplant patients to successfully prevent three of the most problematic post-transplant viruses affecting this group of patients that have yet to be addressed clinically -- cytomegalovirus, Epstein-Barr virus, and adenovirus.

Contact: Glenna Vickers
picton@bcm.edu
713-798-4710
Baylor College of Medicine

Public Release: 29-Apr-2015
95th Annual American Association for Thoracic Surgery Meeting
Five-year survivors of esophageal cancer still face low but constant risks
In 2015 about 17,000 new cases of esophageal cancer will be diagnosed; about 15,600 people will die from the disease. While the five-year survival rate in the 1960s and 1970s was only about 5 percent, improvements in diagnosis, treatment, and management have led to improved survival. A presentation at the AATS Annual Meeting shows that while five-year survival is up to 39 percent, these patients still face many health risks and should be monitored for 10 years or more.

Contact: Nicole Baritot
press@aats.org
978-299-4520
American Association for Thoracic Surgery

Public Release: 28-Apr-2015
95th Annual American Association for Thoracic Surgery Meeting
New studies examine the significant risk of blood clots in post-surgical lung cancer patients
In the first prospective study of its kind, the incidence of VTE was found to be higher than previously reported (5.4 percent VTE-specific mortality rate). A second report highlights the importance of screening for VTEs; the majority of lower extremity VTEs found after pneumonectomy would have gone undiagnosed and untreated without screening. The third report describes a risk assessment tool for VTEs that is applied for the first time to predict an individual's risk of VTEs after lung cancer surgery.

Contact: Nicole Baritot
press@aats.org
978-299-4520
American Association for Thoracic Surgery

Public Release: 28-Apr-2015
95th Annual American Association for Thoracic Surgery Meeting
Simple, active intervention program after major thoracic surgery reduces ER visits and saves money
Alarmingly, readmission after pulmonary resection for lung cancer has been associated with worse outcomes, including higher mortality. Thus, reducing readmissions after thoracic surgery can both save lives and reduce healthcare costs. Studies have shown that programs that improve the transition from hospital to post-discharge care can be effective in decreasing ER visits and re-hospitalization. This study describes for the first time the benefits of an active, post-discharge intervention that begins in the hospital for patients who have undergone thoracic surgery.

Contact: Nicole Baritot
press@aats.org
978-299-4520
American Association for Thoracic Surgery

Public Release: 28-Apr-2015
AGS unveils revised Choosing Wisely list of topics to talk about with older adults
AGS updates to a list of tests and treatments to talk about with older adults reflect an expert review of new research on several important conditions impacting older patients, including agitation, certain types of cancer, delirium, dementia, diabetes, insomnia, unintended weight loss, and certain other health concerns that may warrant deeper discussion based on new insights and information on appropriate health care choices.

Contact: Daniel E. Trucil
dtrucil@americangeriatrics.org
212-822-3589
American Geriatrics Society

Public Release: 28-Apr-2015
Journal of the National Cancer Institute
History of breastfeeding associated with reduced risk of breast cancer recurrence
Women diagnosed with breast cancer who previously breastfed their babies had a 30 percent overall decreased risk of the disease recurring, according to a new Kaiser Permanente study published in the Journal of the National Cancer Institute. In addition, researchers found that the protective effect of breastfeeding was more pronounced for tumors of particular genetic subtypes, including the most commonly diagnosed of all breast cancers.
National Institutes of Health, Huntsman Cancer Institute

Contact: Susan Saito
susan.m.saito@kp.org
510-267-7613
Kaiser Permanente

Public Release: 28-Apr-2015
95th Annual American Association for Thoracic Surgery Meeting
Pneumonectomy or lobectomy?
Prior investigations have shown that different resection procedures for non-small cell lung cancer have very different outcomes, with pneumonectomy associated with three-fold higher mortality than other resection types. While it is understandable that pathological and physiological factors influence a surgeon's choice of surgery for a particular patient, the results presented in this study suggest that physician discomfort with the operative complexities of a procedure may lead to selection of a technique associated with less favorable outcomes.

Contact: Nicole Baritot
press@aats.org
978-299-4520
American Association for Thoracic Surgery

Public Release: 28-Apr-2015
Nature Communications
Two-week international diet swap shows potential effects of food on colon cancer risk
African-Americans and Africans who swapped their typical diets for just two weeks similarly exchanged their respective risks of colon cancer as reflected by alterations of their gut bacteria, according to an international study led by researchers at the University of Pittsburgh School of Medicine published online in Nature Communications.
National Institutes of Health, National Institute for Health Research Imperial Biomedical Research Centre

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
University of Pittsburgh Schools of the Health Sciences

Public Release: 28-Apr-2015
Nature Neuroscience
A glitch in the recycling
In studying the molecular biology of brain development, a team of researchers led by Ludwig Stockholm director Thomas Perlmann has discovered how disruption of a developmental mechanism alters the very nerve cells that are most affected in Parkinson's disease. The results of their study, which took nearly four years to complete and involved the targeted manipulation of mouse genes to generate a model of the disease, are published in the current issue of Nature Neuroscience.
Ludwig Cancer Research, European Union's Seventh Framework Programme, Swedish Strategic Research Foundation, Swedish Research Council, Hjärnfonden, Parkinsonfonden.

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research

Public Release: 28-Apr-2015
Molecular Nutrition and Food Research
Gene mapping reveals soy's dynamic, differing roles in breast cancer
Scientists at Illinois map genes affected by phytonutrients in soy, find that minimally processed soy flour suppresses breast cancer, while purified isoflavones stimulate genes that accelerate tumor growth, raising questions about soy supplements' safety for postmenopausal women.

Contact: Sharita Forrest
slforres@illinois.edu
217-244-1072
University of Illinois at Urbana-Champaign

Public Release: 28-Apr-2015
Nature Communications
U-Michigan scientists observe deadly dance between nerves and cancer cells
In certain types of cancer, nerves and cancer cells enter an often lethal and intricate waltz where cancer cells and nerves move toward one another and eventually engage in such a way that the cancer cells enter the nerves.

Contact: Laura Bailey
baileylm@umich.edu
734-647-1848
University of Michigan

Public Release: 28-Apr-2015
Cell Transplantation
Studies in cell transplantation show beneficial effects for variety of serious conditions
A special issue of Cell Transplantation is devoted to work presented at a recent meeting of ASNTR, a society focused on cell therapy, stem cells, gene therapy and biopharmaceuticals for neurological injury and disease, include: MSCs promote improvement after complete spinal cord injury; bone marrow culture enhances human neural stem cells; primate model of Parkinson's disease upgrades endogenous neurons; human pluripotent stem cells hold promise for Parkinson's disease; and anti-tumor secretion effects on glioblastoma-like cells.

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair

Public Release: 28-Apr-2015
BMJ Open
Two-thirds of bowel cancer patients aren't advised to exercise despite health benefits
More than two-thirds (69 percent) of bowel cancer patients say they weren't advised to exercise regularly after their diagnosis.

Contact: Emily Head
emily.head@cancer.org.uk
44-203-469-6189
Cancer Research UK

Public Release: 27-Apr-2015
Nature Genetics
New breast cancer gene identified by Women's College Hospital scientists
A new breast cancer gene has been identified in a study led by Women's College Hospital researcher Dr. Mohammad Akbari, who is also an assistant professor with the Dalla Lana School of Public Health at the University of Toronto. The study, which was published online today in Nature Genetics, describes how mutations in a gene called RECQL are strongly linked to the onset of breast cancer in two populations of Polish and French-Canadian women.

Contact: Rebecca Cheung
rebecca.cheung@wchospital.ca
416-323-6400 x3210
Women's College Hospital

Public Release: 27-Apr-2015
Journal of Clinical Oncology
Physical exercise helps women with breast cancer to better tolerate chemotherapy
Women with breast cancer who follow a physical exercise program during their chemotherapy treatment experience less side effects like fatigue, reduced physical fitness, nausea and pain. It is also less often necessary to adjust the dosage of their chemotherapy. This is shown by a study supervised by Dr. Neil Aaronson of the Netherlands Cancer Institute.
Alpe d'Huzes, Dutch Cancer Society

Contact: Danielle Cardozo
d.cardozo@nki.nl
31-205-122-867
Netherlands Cancer Institute

Public Release: 27-Apr-2015
Clinical Neurophysiology
'Chemo brain' is real, say UBC researchers
UBC research shows that chemotherapy can lead to excessive mind wandering and an inability to concentrate. Dubbed 'chemo-brain,' the negative cognitive effects of the cancer treatment have long been suspected, but the UBC study is the first to explain why patients have difficulty paying attention.
Canadian Breast Cancer Foundation BC/Yukon

Contact: Heather Amos
heather.amos@ubc.ca
604-822-3213
University of British Columbia

Public Release: 27-Apr-2015
Journal of National Cancer Institute
Mayo Clinic-led research team identifies master switch for cancer-causing HER2 protein
Herceptin has been touted as a wonder drug for women with HER2-positive breast cancer, an aggressive form of the disease that is fueled by excess production of the HER2 protein. However, not all of these patients respond to the drug, and many who do respond eventually acquire resistance.

Contact: Joe Dangor
newsbureau@mayo.edu
507-284-5005
Mayo Clinic

Public Release: 27-Apr-2015
Pediatrics
HPV vaccine should not be delayed
New research out of Queen's University shows early benefits from the human papillomavirus vaccine in young girls.

Contact: Anne Craig
anne.craig@queensu.ca
613-533-2877
Queen's University

Public Release: 27-Apr-2015
Gastroenterology
Gastroenterology Special Issue confirms: You are what you eat
The editors of Gastroenterology, the official journal of the American Gastroenterological Association, are pleased to announce the publication of this year's highly anticipated special 13th issue on food, the immune system and the gastrointestinal tract.

Contact: Rachel Steigerwald
media@gastro.org
301-272-1603
American Gastroenterological Association

Public Release: 27-Apr-2015
Endoplasmic Reticulum Stress in Diseases
Oil or fat?
Palmitate, the major saturated fatty acid in our diet, is known to cause ER stress and cell death in a number of cell types. On the contrary, monounsaturated fatty acid oleate is protective to cells. This research shows that palmitate-treated cardiomyocytes display a distinct lipid staining with BODIPY from cells treated with oleate. Palmitate induces ER stress and cell death whereas oleate provides protection against palmitate-induced ER stress and cell toxicity.

Contact: Maria Hrynkiewicz
maria.hrynkiewicz@degruyteropen.com
48-660-476-421
De Gruyter Open

Showing releases 251-275 out of 1359.

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