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Showing releases 251-275 out of 1281.

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Public Release: 19-Jun-2014
Cell
Feel-good hormones could cause UV addiction
Sun lovers eagerly flock to the beach every summer, despite widespread awareness of the risk of skin cancer. A new study reveals that chronic exposure to UV radiation causes the release of feel-good hormones called endorphins, which act through the same pathway as heroin, leading to physical dependence, tolerance, and addiction-like behavior in rodents. The findings could explain why people have an instinctive desire to be in the sun, despite its known health risks.

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press

Public Release: 19-Jun-2014
Cell
Stanford bioengineers invent a way to speed up drug discovery
The 500 or so kinase proteins are particularly important to drug discovery. Kinases are messenger/signaling proteins that regulate and orchestrate the actions of other proteins. Proper kinase activity maintains health. Irregular activity is linked to cancer and other diseases. Many drugs seek to either boost or suppress kinase activity. Stanford bioengineers have invented a way to observe and report on the behavior of these signaling proteins as they work inside living cells.

Contact: Tom Abate
tabate@stanford.edu
650-736-2245
Stanford School of Engineering

Public Release: 19-Jun-2014
Cell
UV-induced beta-endorphin production causes addiction-like symptoms in mice
A new study from Massachusetts General Hospital investigators adds important support to the theory that ultraviolet light can actually be addictive, finding that chronic UV exposure raises circulating levels of beta-endorphin in mice and that UV-habituated mice exhibit withdrawal symptoms if beta-endorphin activity is blocked.
National Institutes of Health, Melanoma Research Alliance, US-Israel Binational Science Foundation, Adelson Medical Research Foundation

Contact: Terri Ogan
togan@partners.org
617-726-0954
Massachusetts General Hospital

Public Release: 19-Jun-2014
Journal of the National Cancer Institute
A shorter time to the first cigarette of the day is associated with risk of lung cancer
Standard markers of nicotine dependency include cigarettes smoked per day, duration of smoking, and cumulative exposure (pack years), but another marker of addiction, time to first cigarette of the day, may also be associated with the risk of getting lung cancer in both heavy and light smokers, according to a study published June 19 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
Zachary.Rathner@oup.com
919-677-2697
Oxford University Press USA

Public Release: 19-Jun-2014
Pigment Cell & Melanoma Research
Study offers evidence that sunscreen use in childhood prevents melanoma in adults
Research conducted at the Texas Biomedical Research Institute, published in the latest issue of the scientific journal Pigment Cell and Melanoma, has established unequivocally in a natural animal model that the incidence of malignant melanoma in adulthood can be dramatically reduced by the consistent use of sunscreen in infancy and childhood.
Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation

Contact: Mary Uhlig
muhlig@dublinandassociates.com
210-227-0221 x223
Texas Biomedical Research Institute

Public Release: 19-Jun-2014
Cell
Cleveland Clinic researchers discover protein that inhibits tumor growth
A previously unknown variant of an extensively studied protein has been found to inhibit the growth of tumors and slow the development of new blood vessels necessary for cancers to metastasize, according to Cleveland Clinic research published today in Cell.
National Institutes of Health

Contact: Laura Ambro
ambrol@ccf.org
216-636-5876
Cleveland Clinic

Public Release: 19-Jun-2014
PLOS Genetics
Strict diet suspends development, doubles lifespan of worms
Researchers at Duke University found that taking food away from C. elegans triggers a state of arrested development: while the organism continues to wriggle about, foraging for food, its cells and organs are suspended in an ageless, quiescent state. When food becomes plentiful again, the worm develops as planned, but can live twice as long as normal.
American Cancer Society, National Institutes of Health

Contact: Karl Bates
karl.bates@duke.edu
919-681-8054
Duke University

Public Release: 19-Jun-2014
Cell
Computer-designed protein triggers self-destruction of Epstein-Barr-infected cancer cells
A protein molecule, BINDI, has been built to trigger self-destruction of cancer cells infected with the Epstein-Barr virus.
National Institutes of Health, Washington Life Sciences Discovery Fund, US Defense Threat Reduction Agency, and others

Contact: Elizabeth Hunter
elh415@uw.edu
206-616-3192
University of Washington - Health Sciences/UW News, Community Relations & Marketing

Public Release: 19-Jun-2014
Proceedings of the National Academy of Sciences
Possible new combination treatment for cancer
Scientists at the Sahlgrenska Academy have developed a new cancer treatment that has proved to be effective in mice. The treatment, which is presented in the prestigious scientific journal PNAS, is based on newly discovered properties of the so-called BET bromodomain inhibitors.

Contact: Krister Svahn
krister.svahn@sahlgrenska.gu.se
0046-031-786-3869
University of Gothenburg

Public Release: 19-Jun-2014
JAMA Surgery
African American women with breast cancer less likely to have newer, recommended surgical procedure
African American women with early stage, invasive breast cancer were 12 percent less likely than Caucasian women with the same diagnosis to receive a minimally invasive technique, axillary sentinel lymph node biopsy, even as the procedure had become the standard of surgical practice, according to research from The University of Texas MD Anderson Cancer Center.

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center

Public Release: 19-Jun-2014
Lancet Oncology
Researcher discovers ovarian cancer treatment
Doctors at the University of Arizona Cancer Center at St. Joseph's Hospital and Medical Center in Phoenix reported today in Lancet Oncology that a new treatment for ovarian cancer can improve response rates (increase the rate of tumor shrinkage) and prolong the time until cancers recur. In addition, this breakthrough showed a trend in improving survival although these data are not yet mature.

Contact: lynne Reaves
lynne.reaves@dignityhealth.org
602-406-4734
St. Joseph's Hospital and Medical Center

Public Release: 19-Jun-2014
Cell
Scientists identify additional challenges in KRAS-driven cancers
Scientists have redoubled efforts to disable the mutated cancer gene KRAS, which confers an especially poor prognosis and has proved extraordinarily difficult to target. New research reported in the journal Cell has identified an additional hurdle: inhibiting KRAS can activate a backup pathway in cancer cells that enables them to survive and thrive in the oncogene's absence.
NIH/National Cancer Institute, Koch Institute

Contact: Teresa M Herbert
teresa_herbert@dfci.harvard.edu
617-632-5653
Dana-Farber Cancer Institute

Public Release: 18-Jun-2014
New England Journal of Medicine
New report offers a primer for doctors' use of clinical genome and exome sequencing
Sooner than almost anyone expected, a new, genome-based technology for demystifying undiagnosed illnesses -- particularly rare childhood diseases -- is moving from research laboratories into general medical practice. Now, two leading scientists, writing in the June 19, 2014, issue of the New England Journal of Medicine, have sketched out what doctors need to know in order to use the new technology effectively.
National Institutes of Health

Contact: Raymond MacDougall
macdougallr@mail.nih.gov
301-443-3523
NIH/National Human Genome Research Institute

Public Release: 18-Jun-2014
JAMA Surgery
Racial disparities in sentinel lymph node biopsy in women with breast cancer
The use of sentinel lymph node biopsy to stage early breast cancer increased in both black and white women from 2002 to 2007, but the rates remained lower in black than white patients, a disparity that contributed to disparities in the risk for lymphedema (arm swelling common after breast cancer treatment because of damage to the lymphatic system).

Contact: Julie A. Penne
jpenne@mdanderson.org
713-792-0662
The JAMA Network Journals

Public Release: 18-Jun-2014
British Journal of Obstetrics and Gynaecology
No link found between soy food and endometrial cancer risk, say researchers
Researchers have found no evidence of a protective association between soy food and endometrial cancer risk, says a new study published June 18 in BJOG: An International Journal of Obstetrics and Gynaecology.

Contact: Nicole Weingartner
sciencenewsroom@wiley.com
201-748-5808
Wiley

Public Release: 18-Jun-2014
Tobacco Control
Study shows cost-effectiveness of smoking cessation counseling during hospitalization
In a recent study published in Tobacco Control, researchers at the University of Ottawa Heart Institute have demonstrated the cost-effectiveness of the Ottawa Model for Smoking Cessation, an intervention that includes in-hospital counseling, pharmacotherapy and post-hospital follow-up, compared to usual care among smokers hospitalized with acute myocardial infarction, unstable angina, heart failure, and chronic obstructive pulmonary disease.

Contact: Vincent Lamontagne
vlamontagne@ottawaheart.ca
613-761-4427
University of Ottawa Heart Institute

Public Release: 18-Jun-2014
Cancer Immunology Research
Vaccine 'reprograms' pancreatic cancers to respond to immunotherapy
Researchers at the Johns Hopkins Kimmel Cancer Center have developed and tested a vaccine that triggered the growth of immune cell nodules within pancreatic tumors, essentially reprogramming these intractable cancers and potentially making them vulnerable to immune-based therapies.
NIH/National Cancer Institute

Contact: Michelle Potter
mpotter8@jhmi.edu
410-614-2914
Johns Hopkins Medicine

Public Release: 18-Jun-2014
Journal of Clinical Oncology
Telephone call is effective support when breast cancer treatment includes weight loss
A series of simple telephone calls can make a profound difference in helping women to meet their treatment goals for breast cancer, according to a randomized trial of women who are also obese.

Contact: Polly Thompson
pthompson@lunenfeld.ca
41-658-648-002-046
Lunenfeld-Tanenbaum Research Institute

Public Release: 18-Jun-2014
American Society of Clinical Oncology 2014 Conference
Breathalyzer test may detect deadliest cancer
Lung cancer causes more deaths in the US than the next three most common cancers combined. Now a new breathalyzer test, embedded with a 'NaNose' nanotech chip to literally 'sniff out' cancer tumors, has been developed by a team of international researchers including Prof. Nir Peled of Tel Aviv University's Sackler Faculty of Medicine. It may turn the tide by both accurately detecting lung cancer and identifying its stage of progression.

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University

Public Release: 18-Jun-2014
Cancer
False negative results found in prognostic testing for breast cancer
Researchers retested tumor samples from a large group of women and found that 22 out of 530 women had their tumor type incorrectly classified in local labs, which precluded them from effective treatment options.
Roche-Genentech, Inc.

Contact: Donna Dubuc
donna.M.Dubuc@Dartmouth.edu
603-653-3615
The Geisel School of Medicine at Dartmouth

Public Release: 18-Jun-2014
PLOS Genetics
Following direction: How neurons can tell top from bottom and front from back
The question of how neurons and their axons establish spatial polarity and direction in tissues and organs is a fundamental question of any organism or biological system. Our cells and axons precisely orient themselves in response to external cues, but what are the core pathways and how are they integrated?
Canadian Institutes of Health Research

Contact: Polly Thompson
pthompson@lunenfeld.ca
41-658-648-002-046
Lunenfeld-Tanenbaum Research Institute

Public Release: 18-Jun-2014
eLife
Scripps Research Institute scientists reveal molecular 'yin-yang' of blood vessel growth
Biologists at The Scripps Research Institute have discovered a crucial process that regulates the development of blood vessels. The finding could lead to new treatments for disorders involving abnormal blood vessel growth, including common disorders such as diabetic retinopathy and cancer.
National Institutes of Health, National Foundation for Cancer Research

Contact: Madeline McCurry-Schmidt
madms@scripps.edu
858-784-9254
Scripps Research Institute

Public Release: 17-Jun-2014
$2.4 million NIH center grant to develop a cleaner, healthier environment in Detroit
With over $2.4 million in new federal funding, Wayne State University researchers, regional collaborators at Henry Ford Health System, the University of Michigan and Michigan State University, and community partners will study how exposures to stressors that are prevalent in the urban industrialized environment -- both chemical and non-chemical -- impact human health in Detroit and beyond.
NIH/National Institute of Environmental Health Sciences

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research

Public Release: 17-Jun-2014
Tobacco Control
Want to know about vaping? Turn on the TV or go online
UIC study finds social networking is a critical component of e-cig marketing.

Contact: Sherri McGinnis Gonzalez
smcginn@uic.edu
312-996-8277
University of Illinois at Chicago

Public Release: 17-Jun-2014
American Journal of Roentgenology
3D breast imaging could revolutionize cancer screening
The largest report to date shows that 3D DBT (versus 2D DM) increases the detection rate for cancer overall by 28.6 percent and by 43.8 percent in detecting invasive cancers.

Contact: Lissa D. Hurwitz
lhurwitz@arrs.org
703-858-4332
American Roentgen Ray Society

Showing releases 251-275 out of 1281.

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