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Showing releases 251-275 out of 1261.

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Public Release: 25-Aug-2014
Cell Reports
Drug used for DNA repair defects could treat leukemia and other cancers more effectively
A team of scientists led by research associate professor Motomi Osato and professor Yoshiaki Ito from the Cancer Science Institute of Singapore at the National University of Singapore found that a drug originally designed for killing a limited type of cancer cells with DNA repair defects could potentially be used to treat leukemia and other cancers.

Contact: Kimberley Wang
kimberley.wang@nus.edu.sg
National University of Singapore

Public Release: 25-Aug-2014
Journal of Cell Biology
Deploying exosomes to win a battle of the sexes
A new study provides further detail into how male fruit flies ensure reproductive success by deploying exosomes to alter the mating behavior of females. The findings also identify a signaling pathway that might play a role in human cancers of tissues that secrete exosomes, such as the prostate and breast.
Wellcome Trust, Oxford Cancer Research Centre, Cancer Research UK, Biotechnology and Biological Sciences Research Council, Medical Research Council, and others

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press

Public Release: 25-Aug-2014
CANCER
Medicaid reimbursements may affect cancer screening rates among beneficiaries
A recent study has found that in states with higher Medicaid payments for office visits, Medicaid beneficiaries were more likely to be screened for breast, cervical, and colorectal cancer.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
Wiley

Public Release: 25-Aug-2014
Genome Biology
RNA sequence could help doctors to tailor unique prostate cancer treatment programs
Sequencing RNA, not just DNA, could help doctors predict how prostate cancer tumors will respond to treatment, according to research published in the open-access journal Genome Biology. Because a tumor's RNA shows the real time changes a treatment is causing, the authors think this could be a useful tool to aid diagnosis and predict which treatment will most benefit individual cancer patients.

Contact: Shane Canning
shane.canning@biomedcentral.com
44-203-192-2429
BioMed Central

Public Release: 25-Aug-2014
JAMA Internal Medicine
Study shows 25 percent fewer opioid-related deaths in states allowing medical marijuana
On average, states allowing the medical use of marijuana have lower rates of deaths resulting from opioid analgesic overdoses than states without such laws. A new multi-institutional study, published in JAMA Internal Medicine and led by researchers at the Perelman School of Medicine at the University of Pennsylvania, shows that on average, the 13 states allowing the use of medical marijuana had a 24.8 percent lower annual opioid overdose mortality rate after the laws were enacted than states without the laws.
National Institutes of Health

Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-349-5964
University of Pennsylvania School of Medicine

Public Release: 25-Aug-2014
Genome Medicine
Cancer leaves a common fingerprint on DNA
Regardless of their stage or type, cancers appear to share a telltale signature of widespread changes to the so-called epigenome, according to a team of researchers. In a study published online in Genome Medicine on Aug. 26, the investigators say they have found widespread and distinctive changes in a broad variety of cancers to chemical marks known as methyl groups attached to DNA, which help govern whether genes are turned 'on' or 'off.'
NIH/National Human Genome Research Institute, NIH/National Cancer Institute, NIH/National Institute of General Medical Sciences, NIH/National Center for Research Resources

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine

Public Release: 25-Aug-2014
JAMA Pediatrics
Weekend hospitalization linked to longer stay for pediatric leukemia patients
Weekend admission to the hospital for pediatric patients newly diagnosed with leukemia was associated with a longer length of stay, slightly longer wait to start chemotherapy and higher risk for respiratory failure but weekend admissions were not linked to an increased risk for death.

Contact: Rachel Salis-Silverman
salis@email.chop.edu
267-426-6063
The JAMA Network Journals

Public Release: 24-Aug-2014
Nature Medicine
Study suggests repurposing anti-depressant medication to target medulloblastoma
An international research team reports in Nature Medicine a novel molecular pathway that causes an aggressive form of medulloblastoma, and suggests repurposing an anti-depressant medication to target the new pathway may help combat one of the most common brain cancers in children. The scientists say their laboratory findings in mouse models of the disease could lead to a more targeted and effective molecular therapy that would also reduce the harmful side effects of current treatments.
National Institutes of Health, Canadian Institutes of Health Research

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center

Public Release: 22-Aug-2014
Cancer Epidemiology
Smokers consume same amount of cigarettes regardless of nicotine levels
Cigarettes with very low levels of nicotine may reduce addiction without increasing exposure to toxic chemicals, according to a new study from the University of Waterloo.

Contact: Pamela Smyth
psmyth@uwaterloo.ca
519-888-4777
University of Waterloo

Public Release: 22-Aug-2014
Journal of the National Cancer Institute
Scientists map risk of premature menopause after cancer treatment
Women treated for the cancer Hodgkin lymphoma will be able to better understand their risks of future infertility after researchers estimated their risk of premature menopause with different treatments. The findings, set out in the Journal of the National Cancer Institute, are based on the experience of more than 2,000 young women in England and Wales treated for the cancer over a period of more than 40 years.

Contact: Graham Shaw
henry.french@icr.ac.uk
020-715-35380
Institute of Cancer Research

Public Release: 22-Aug-2014
Inflammatory Bowel Diseases
Study shows epigenetic changes in children with Crohn's disease
A new study finds a wide range of epigenetic change -- alterations in DNA across the genome that may be related to key environmental exposures -- in children with Crohn's disease, reports Inflammatory Bowel Diseases, official journal of the Crohn's & Colitis Foundation of America. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health

Public Release: 22-Aug-2014
Nature Communications
Genetics and lifestyle have a strong impact on biomarkers for inflammation and cancer
In a new study published in Nature Communications, research scientists from Uppsala University present for the first time a large-scale study of the significance of genetic, clinical and lifestyle factors for protein levels in the bloodstream. The results of the study show that genetics and lifestyle are determining factors for protein levels, a discovery which greatly influences the possibilities for using more biomarkers to identify disease.

Contact: Stefan Enroth
stefan.enroth@igp.uu.se
46-018-471-4913
Uppsala University

Public Release: 22-Aug-2014
Preventive Medicine
Women with severe, chronic health issues are screened for breast cancer less often
Women with severe disabilities and multiple chronic conditions are screened for breast cancer less often than women with no disabilities or no chronic conditions, a new study has found.

Contact: Geoff Koehler
koehlerg@smh.ca
416-864-6060 x6537
St. Michael's Hospital

Public Release: 22-Aug-2014
Journal of Thoracic Oncology
High concordance between EGFR mutations from circulating-free tumor DNA and tumor tissue in non-small cell lung cancer
Epidermal growth factor receptor mutations found in the circulating free tumor DNA from the plasma of advanced non-small cell lung cancer patients correlates well with the epidermal growth factor receptor mutations from patient-matched tumor tissue DNA.

Contact: Rob Mansheim
rob.mansheim@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Public Release: 22-Aug-2014
Cell Death & Disease
New enzyme targets for selective cancer therapies
A University of Alberta team has designed compounds that target brain cancer.

Contact: Bryan Alary
bryan.alary@ualberta.ca
780-492-0436
University of Alberta

Public Release: 22-Aug-2014
Journal of Thoracic Oncology
Novel oncogenic RET mutation found in small cell lung cancer
For the first time an oncogenic somatic mutation at amino acid 918 in the rearranged during transfection protein has been identified in small cell lung cancer tumors and enforced expression of this mutation within small cell lung cancer tumor cell lines produced increased intracellular signaling and cell growth.

Contact: Rob Mansheim
rob.mansheim@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Public Release: 22-Aug-2014
Journal of Thoracic Oncology
Deletion predicts survival in advanced non-small cell lung cancer
Bcl-2-like protein 11 deletion in advanced non-small cell lung cancer is associated with shorter progression free survival in epidermal growth factor receptor tyrosine kinase inhibitor or chemotherapy treated Asian patients. Also, Bcl-2-like protein 11 deletion independently predicts overall survival of advanced non-small cell lung cancer patients.

Contact: Rob Mansheim
rob.mansheim@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Public Release: 21-Aug-2014
Cancer Cell
Sequence of rare kidney cancer reveals unique alterations involving telomerase
An international scientific collaboration led by Baylor College of Medicine has revealed clues about genetic alterations that may contribute to a rare form of kidney cancer, providing new insights not only into this rare cancer but other types as well.

Contact: Glenna Picton
picton@bcm.edu
713-798-7973
Baylor College of Medicine

Public Release: 21-Aug-2014
JAMA Otolaryngology Head Neck Surgery
Surgery associated with better survival for patients with advanced laryngeal cancer
Patients with advanced laryngeal cancer appear to have better survival if they are treated with surgery than nonsurgical chemoradiation.

Contact: Sid Dinsay
sid.dinsay@mountsinai.org
212-241-9200
The JAMA Network Journals

Public Release: 21-Aug-2014
Carcinogenesis
Research offers insight into cellular biology of colorectal cancer
Kristi Neufeld has spent the better part of her career trying to understand the various activities of APC, a protein whose functional loss is thought to initiate roughly 80 percent of all colon polyps.
National Institutes of Health

Contact: Brendan M. Lynch
blynch@ku.edu
785-864-8855
University of Kansas

Public Release: 20-Aug-2014
JAMA Surgery
Patient perspectives on breast reconstruction following mastectomy
Less than 42 percent of women underwent breast reconstruction following a mastectomy for cancer, and the factors associated with foregoing reconstruction included being black, having a lower education level and being older.

Contact: Emily O'Donnell
odonnele@mskcc.org
212-639-6339
The JAMA Network Journals

Public Release: 20-Aug-2014
Science Translational Medicine
Severing nerves may shrink stomach cancers: Botox injections slow growth of tumors in mice
Research from Columbia University Medical Center shows that nerves may play a critical role in stomach cancer growth and that blocking nerve signals using surgery or Botox could be an effective treatment for the disease.
National Institutes of Health

Contact: Lucky Tran
lt2549@cumc.columbia.edu
212-305-3689
Columbia University Medical Center

Public Release: 20-Aug-2014
Pigment Cell & Melanoma Research
Scientists learn more about rare skin cancer that killed Bob Marley
Acral melanomas, the rare type of skin cancer that caused Bob Marley's death, are genetically distinct from other types of skin cancer.
Cancer Research UK

Contact: Flora Malein
flora.malein@cancer.org.uk
44-020-346-96189
Cancer Research UK

Public Release: 20-Aug-2014
Cancer Cell
Blueprint for next generation of chronic myeloid leukemia treatment
Researchers at Huntsman Cancer Institute at the University of Utah have identified and characterized mutated forms of the gene that encodes BCR-ABL, the unregulated enzyme driving the blood cancer chronic myeloid leukemia.
NIH/National Cancer Institute, Howard Hughes Medical Institute, Huntsman Cancer Institute, Leukemia & Lymphoma Society, American Society of Hematology

Contact: Linda Aagard
801-587-7639
University of Utah Health Sciences

Public Release: 20-Aug-2014
Journal of Urology
Severe infections with hospitalization after prostate biopsy rising in Sweden
Transrectal ultrasound guided biopsy is the gold standard for detecting prostate cancer, but international reports have suggested that the number of risks associated with the procedure is increasing. In a new nationwide population-based study, Swedish researchers found that six percent of men filled a prescription for antibiotics for a urinary tract infection within 30 days after having a prostate biopsy, with a twofold increase in hospital admissions over five years, reports The Journal of Urology.

Contact: Linda Gruner
jumedia@elsevier.com
212-633-3923
Elsevier Health Sciences

Showing releases 251-275 out of 1261.

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