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Showing releases 251-275 out of 1312.

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Public Release: 23-Jul-2015
Genome Medicine
Novel algorithm identifies DNA copy-number landscapes in African American colon cancers
The algorithm ENVE could be the Google for genetic aberrations -- and it comes from Case Western Reserve. The findings about the algorithm that distinguishes 'noise' from real evidence, as well as some genetic characteristics of colon cancer in African Americans, appears this week in Genome Medicine.
US Public Health Service, GI SPORE, Breast Cancer Research Foundation, Rosalie and Morton Cohen Family Memorial Genomics Fund of University Hospitals Case Medical Center, Clinical and Translational Collaborative of Cleveland

Contact: Jeannette Spalding
Case Western Reserve University

Public Release: 23-Jul-2015
JAMA Oncology
Chemotherapy and quality of life at the end of life
Chemotherapy for patients with end-stage cancer was associated with worse quality of life near death for patients with a good ability to still perform many life functions, according to an article published online by JAMA Oncology.

Contact: Jen Gundersen
The JAMA Network Journals

Public Release: 23-Jul-2015
Cell Reports
Opening the door to the cause of myeloid leukemia: Finding the targets of common mutation
Researchers at the University of Birmingham have made a breakthrough in understanding how mutated genes in leukemia reprogram blood stem cells and send them spiraling out of control.

Contact: Luke Harrison
University of Birmingham

Public Release: 23-Jul-2015
Cell Stem Cell
Access denied: Leukemia thwarted by cutting off link to environmental support
A new study by researchers at University of California, San Diego School of Medicine reveals a protein's critical -- and previously unknown -- role in the development and progression of acute myeloid leukemia, a fast-growing and extremely difficult-to-treat blood cancer.
NIH/National Cancer Institute, National Institutes of Health, Lymphoma and Leukemia Society

Contact: Bonnie Ward
University of California - San Diego

Public Release: 23-Jul-2015
Mayo Clinic Proceedings
Leading experts prescribe how to make cancer drugs more affordable
A group of 118 of the nation's leading cancer experts have drafted a prescription for reducing the high cost of cancer drugs and voiced support for a patient-based grassroots movement demanding action on the issue. Their recommendations and support are outlined in a commentary, co-authored by the group, in the journal Mayo Clinic Proceedings.

Contact: Joe Dangor
Mayo Clinic

Public Release: 23-Jul-2015
The Lancet
Estrogen-suppressing drugs substantially reduce breast cancer deaths
A class of hormonal drugs called aromatase inhibitors substantially reduce the risk of death in postmenopausal women with the most common type of breast cancer, a major study of more than 30,000 women shows. The research underlines the importance of aromatase inhibitors in the treatment of oestrogen receptor (ER)-positive breast cancer -- and shows they reduce risk of death by significantly more than the older hormonal treatment tamoxifen.
Cancer Research UK, Medical Research Council

Contact: Claire Hastings
Institute of Cancer Research

Public Release: 23-Jul-2015
International Journal of Radiation Oncology, Biology, Physics
Moffitt researchers develop first genetic test to predict tumor sensitivity to radiation therapy
Moffitt Cancer Center researchers have contributed to these advances by developing the first test that analyzes the sensitivity of tumors to radiation therapy. They discovered that colon cancer metastases have varying sensitivity to radiation therapy based on their anatomic location.
National Institutes of Health, US Army, Bankhead-Coley

Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 23-Jul-2015
New 'chemotherapy booster' could treat lung and pancreatic cancer
A new drug that blocks cancer's escape route from chemotherapy could be used to treat deadly lung and pancreatic cancers. Scientists have shown in human cancer cells and in mice that the drug -- discovered at The Institute of Cancer Research, London -- boosts the effectiveness of conventional chemotherapy.
Cancer Research UK, Sareum Limited

Contact: Claire Hastings
Institute of Cancer Research

Public Release: 22-Jul-2015
New England Journal of Medicine
Additional radiation reduces breast-cancer recurrence for some patients: Hamilton study
A study has found no increase in overall survival but a reduction in breast cancer recurrence when additional radiation is given to the lymph nodes as well as the standard treatment of whole-breast irradiation after breast-conserving surgery. The research, which examined the addition of regional nodal irradiation to whole-breast irradiation compared with whole-breast irradiation alone, was published July 22 in the prestigious New England Journal of Medicine.
Canadian Cancer Society Research Institute to the NCIC Clinical TrialsGroup, Canadian Breast Cancer Research Initiative, NIH/National Cancer Institute, Cancer Council of Victoria, New South Wales, Queensland, and South Australia

Contact: Susan Emigh
905-525-9140 x22555
McMaster University

Public Release: 22-Jul-2015
Zebrafish reveal drugs that may improve bone marrow transplant
Using large-scale zebrafish drug-screening models, researchers at Boston Children's Hospital have identified a potent group of chemicals that helps bone marrow transplants engraft or 'take.'
Howard Hughes Medical Institute, National Institutes of Health, NIH/National Cancer Institute, German Research Council, Care-for-Rare Foundation

Contact: Keri Stedman
Boston Children's Hospital

Public Release: 22-Jul-2015
Cochrane Library
Targeting the strain of bacteria that causes ulcers may help prevent stomach cancer
A new review published in the Cochrane Library, indicates that eradicating Helicobacter pylori bacterium -- the main cause of stomach ulcers -- with a short course of therapy comprising two commonly used medicines may help to reduce the risk of gastric cancer.

Contact: Evelyn Martinez

Public Release: 22-Jul-2015
Queen's University Belfast, UK, researchers discover how to cut worrying levels of arsenic
Queen's researchers discover simple solution to worrying levels of arsenic in our rice.

Contact: Una Bradley
Queen's University Belfast

Public Release: 22-Jul-2015
Nature Communications
Poor survival in multiple myeloma patients linked to genetic variation
Researchers have found that multiple myeloma patients with a genetic variation in the gene FOPNL die on average 1-3 years sooner than patients without it. The finding was identified with a genetic mapping technique, genome wide association studies, and verified in patient populations from North America and Europe. Published in Nature Communications, this was the first study to survey the entire human genome for genetic variation influencing survival, and is a first step toward applying precision medicine to multiple myeloma.
Huntsman Cancer Institute, Leukemia & Lymphoma Society, National Institutes of Health, NIH/National Cancer Institute, Utah State Department of Health, Steve & Nancy Grand Multiple Myeloma Translational Initiative, Polish Ministry, Research Fund Sjæl

Contact: Linda Aagard
University of Utah Health Sciences

Public Release: 22-Jul-2015
Modified DNA building blocks are cancer's Achilles heel
In studying how cells recycle the building blocks of DNA, Ludwig Cancer Research scientists have discovered a potential therapeutic strategy for cancer. They found that normal cells have highly selective mechanisms to ensure that nucleosides -- the chemical blocks used to make new strands of DNA -- don't carry extra, unwanted chemical changes. But the scientists also found that some types of cancer cells aren't so selective.
Ludwig Cancer Research, Biotechnology and Biological Sciences Research Council

Contact: Rachel Steinhardt
Ludwig Institute for Cancer Research

Public Release: 22-Jul-2015
New research from Lawson uncovers important molecule in ovarian cancer
Scientists at Lawson Health Research Institute have uncovered an important new target for ovarian cancer therapy. Contrary to current research this new study found that LKB1 is an important molecule in the cancer's promotion and survival. Their research definitively shows that ovarian cancer cells still have LKB1 and that this molecule allows ovarian cancer spheroids to change their metabolism, promote tumor cell survival and make them more resistant to chemotherapy.

Contact: Julia Capaldi
519-685-8500 x75616
Lawson Health Research Institute

Public Release: 22-Jul-2015
Scientists determine structure of important drug target using groundbreaking approach
Using the brightest X-ray laser in the world, scientists have determined the structure of a molecular complex that is responsible for regulating vital physiological functions, and that serves as a major pharmacological drug target.

Contact: Beth Hinshaw Hall
Van Andel Research Institute

Public Release: 21-Jul-2015
Nature Chemical Biology
New 'TripAdvisor' site to address use of substandard biomedical research tools
An international panel of leading scientists is launching a new TripAdvisor-style website aimed at helping researchers choose better-quality research tools - and avoiding potentially serious errors in biomedical research. In a 'call to action' published today, the international expert panel warns that many scientists are unwittingly using poor-quality chemical probes, leading to mistaken conclusions being drawn from research studies.
The Institute of Cancer Research, Broad Institute, Structural Genomics Consortium, Wellcome Trust

Contact: Claire Bithell
Institute of Cancer Research

Public Release: 21-Jul-2015
American Journal of Men's Health
Fatherhood makes men fat
Men gain weight after they become fathers for the first time, reports a large new Northwestern study that tracked the weight of more than 10,000 men from adolescence to young adulthood. The 'fatherhood effect' is an average weight gain of 3.5 to 4.5 pounds after the first child. Men who do not become fathers lose weight during this period. This is a key time for pediatricians to counsel fathers, who often don't have their own doctors.
National Institutes of Men's Health

Contact: Marla Paul
Northwestern University

Public Release: 21-Jul-2015
Examination of use of diabetes drug pioglitazone and risk of bladder cancer
Although some previous studies have suggested an increased risk of bladder cancer with use of the diabetes drug pioglitazone, analyses that included nearly 200,000 patients found no statistically significant increased risk, however a small increased risk could not be excluded, according to a study in the July 21 issue of JAMA.

Contact: Janet Byron
The JAMA Network Journals

Public Release: 21-Jul-2015
Angewandte Chemie International Edition
Dartmouth team conducts first synthesis of molecules that cause rapid cell death in cancer
Dartmouth researchers and their colleagues have carried out the first total syntheses of certain compounds involved in excessive cell death in leukemia.
American Cancer Society, National Institutes of Health, Welch Foundation

Contact: John Cramer
Dartmouth College

Public Release: 21-Jul-2015
Journal of Physiology
Blood vessels can actually get better with age
Oxidative stress has been linked to cardiovascular and neurodegenerative diseases including diabetes, hypertension and age-related cancers. However, researchers at the University of Missouri recently found that aging actually offered significant protection against oxidative stress. These findings suggest that aging may trigger an adaptive response to counteract the effects of oxidative stress on blood vessels.
National Institutes of Health

Contact: Jeffrey Hoelscher
University of Missouri-Columbia

Public Release: 21-Jul-2015
Applying New Jersey population traits to Louisiana reverses colorectal cancer trends
If Louisiana had the same risk factors, screening uptake, and survival rates as New Jersey, incidence and mortality from the disease would drop to levels below that of New Jersey.
NIH/National Cancer Institute, American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 21-Jul-2015
Proceedings of the National Academy of Sciences
PNAS: Evolution not just mutation drives development of cancer
A paper published today in the Proceedings of the National Academy of Sciences argues against the commonly held 'accumulation of mutations' model of oncogenesis in favor of a model that depends on evolutionary pressures acting on populations of cells.
NIH/National Cancer Institute

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 21-Jul-2015
Cochrane Library
Study shows targeting bacteria causing ulcers may prevent stomach cancer
A research review for the Cochrane Library, led by McMaster University researchers, has found that eliminating Helicobacter pylori bacterium -- the main cause of stomach ulcers - with a short course of therapy of two commonly used medicines may help to reduce the risk of gastric cancer.

Contact: Susan Emigh
905-525-9140 x22555
McMaster University

Public Release: 20-Jul-2015
Common chemicals may act together to increase cancer risk, study finds
Common environmental chemicals assumed to be safe at low doses may act separately or together to disrupt human tissues in ways that eventually lead to cancer, a task force reports.
Getting to Know Cancer

Contact: William Bisson
Oregon State University

Showing releases 251-275 out of 1312.

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