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Showing releases 251-275 out of 1212.

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Public Release: 20-Jun-2013
Mutagenesis
Berkeley Lab confirms thirdhand smoke causes DNA damage
A study led by researchers from Lawrence Berkeley National Laboratory has found for the first time that thirdhand smoke -- the noxious residue that clings to virtually all surfaces long after the secondhand smoke from a cigarette has cleared out -- causes significant genetic damage in human cells.
Tobacco-Related Disease Research Program

Contact: Julie Chao
jhchao@lbl.gov
510-486-6491
DOE/Lawrence Berkeley National Laboratory

Public Release: 20-Jun-2013
Cell Reports
Pluripotent cells from pancreatic cancer cells first human model of cancer's progression
Pancreatic cancer carries a dismal prognosis. Researchers and clinicians don't have a non-invasive way to even detect early cells that portent later disease. Scientists have created a research cell line from a patient with advanced pancreatic cancer. This first-of-its-kind human-cell model of pancreatic cancer progression is the first example using induced pluripotent stem cells to model cancer progression directly from a solid tumor and to model pancreatic cancer from early to invasive stages.
NIH/National Institute for General Medical Sciences

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-459-0544
University of Pennsylvania School of Medicine

Public Release: 20-Jun-2013
Fertility and Sterility
Men who can't produce sperm face increased cancer risk, Stanford-led study finds
Men who are diagnosed as azoospermic -- infertile because of an absence of sperm in their ejaculate -- are more prone to developing cancer than the general population, a study led by a Stanford University School of Medicine urologist has found. And a diagnosis of azoospermia before age 30 carries an eight-fold cancer risk, the study says.

Contact: Bruce Goldman
goldmanb@stanford.edu
650-725-2106
Stanford University Medical Center

Public Release: 20-Jun-2013
Cancer Cell
Herding cancer cells to their death
Publishing their findings in today's online issue of Cancer Cell, an international team of scientists led jointly by Professors Colin Goding from the Ludwig Institute for Cancer Research who is based at the University of Oxford and José Neptuno Rodriguez-López from the University of Murcia describe a therapeutic strategy that manipulates a mechanism driving cellular heterogeneity to treat advanced melanoma.
Ludwig Institute for Cancer Research, Ministerio de Ciencia e Innovación, and others

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research

Public Release: 20-Jun-2013
Neuro Oncology
Virus combination effective against deadly brain tumor, Moffitt Cancer Center study shows
A combination of the myxoma virus and the immune suppressant rapamycin can kill glioblastoma multiforme, the most common and deadliest malignant brain tumor, according to Moffitt Cancer Center research. Peter A. Forsyth, M.D., of Moffitt's Neuro-Oncology Program, says the combination has been shown to infect and kill both brain cancer stem cells and differentiated compartments of glioblastoma multiforme.
National Institutes of Health

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 19-Jun-2013
Nature
Biologists identify the chemical behind cancer resistance in naked mole rats
Two researchers at the University of Rochester have discovered the chemical that makes naked mole rats cancer-proof.
National Institutes of Health, Ellison Medical Foundation

Contact: Peter Iglinski
peter.iglinski@rochester.edu
585-273-4726
University of Rochester

Public Release: 19-Jun-2013
Nature
Scientists find new source of versatility so 'floppy' proteins can get things done
Many proteins work like Swiss Army knives, fitting multiple functions into their elaborately folded structures. A bit mysteriously, some proteins manage to multitask even with structures that are unfolded and floppy -- "intrinsically disordered." In this week's issue of Nature, scientists at The Scripps Research Institute report their discovery of an important trick that a well-known intrinsically disordered protein uses to expand and control its functionality.
National Institutes of Health, Skaggs Institute for Chemical Biology at Scripps Research Institute

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute

Public Release: 19-Jun-2013
PLOS ONE
Moffitt Cancer Center researchers identify genetic variants predicting aggressive prostate cancers
Researchers at Moffitt Cancer Center and colleagues at Louisiana State University have developed a method for identifying aggressive prostate cancers that require immediate therapy. It relies on understanding the genetic interaction between single nucleotide polymorphisms. The goal is to better predict a prostate cancer's aggressiveness to avoid unnecessary radical treatment.
NIH/National Cancer Institute, American Cancer Society

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 19-Jun-2013
Nature Communications
Genetics of cervical cancer raise concern about antiviral therapy in some cases
A new understanding of the genetic process that can lead to cervical cancer may help improve diagnosis of potentially dangerous lesions for some women, and also raises a warning flag about the use of anti-viral therapies in certain cases -- suggesting they could actually trigger the cancer they are trying to cure.
National Institutes of Health

Contact: Andrey Morgun
Andriy.morgun@oregonstate.edu
541-737-3424
Oregon State University

Public Release: 19-Jun-2013
New England Journal of Medicine
Ibrutinib continues strong showing against mantle cell lymphoma
In a major international study led by researchers at the University of Texas MD Anderson Cancer Center, the targeted therapy ibrutinib continues to show remarkable promise for the treatment of relapsed or refractory mantle cell lymphoma.

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center

Public Release: 19-Jun-2013
New England Journal of Medicine
Drug shows surprising efficacy as treatment for chronic leukemia, mantle cell lymphoma
Two clinical studies published online in the New England Journal of Medicine suggest that the novel, targeted agent ibrutinib shows real potential is a safe, effective, treatment for adults with chronic lymphocytic leukemia and for patients with mantle cell lymphoma.
Pharmacyclics, Inc.; Leukemia and Lymphoma Society; NIH/National Cancer Institute; D. Warren Brown Foundation

Contact: Liz Bryan
LBryan@spectrumscience.com
202-955-6222
Ohio State University Medical Center

Public Release: 18-Jun-2013
Oncogene
Study shows how the Nanog protein promotes growth of head and neck cancer
Researchers have identified a biochemical pathway in cancer stem cells that is essential for promoting head and neck cancer. The study shows that a protein called Nanog, which is normally active in embryonic stem cells, promotes the growth of cancer stem cells in head and neck cancer. The findings provide information essential for designing novel targeted drugs that might improve the treatment of head and neck cancer.
NIH/National Cancer Institute, American Cancer Society, Joan Bisesi Fund

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center

Public Release: 18-Jun-2013
Cancer Prevention Research
Fat cells in breast may connect social stress to triple-negative breast cancer
Local chemical signals released by fat cells in the mammary gland appear to provide a crucial link between exposure to unrelenting social stressors early in life, and the subsequent development of aggressive breast cancer.
National Institutes of Health, US Army, Department of Defense

Contact: John Easton
john.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center

Public Release: 18-Jun-2013
Cell
An article in 'Cell' reveals a new resistance mechanism to chemotherapy in breast and ovarian cancer
The team led by Spanish National Cancer Research Centre researcher Óscar Fernández-Capetillo, head of the Genomic Instability Group, together with researchers from the National Cancer Institute in the US, have participated in a study that describes the causes that explain why tumors with BRCA1 and BRCA2 mutations stop responding to PARP inhibitor drugs.

Contact: Press Office
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 18-Jun-2013
Cancer Cell
Scientists catch EGFR passing a crucial message to cancer-promoting protein
Researchers have discovered and mapped the signaling network between two previously unconnected proteins, exposing a link that, if broken, could cut off cancer cell growth at its starting point.

Contact: Scott Merville
SMerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center

Public Release: 18-Jun-2013
Proceedings of the National Academy of Sciences
Chemical probe confirms that body makes its own rotten egg gas, H2S, to benefit health
A new study confirms directly what scientists previously knew only indirectly -- that poisonous "rotten egg" gas hydrogen sulfide is generated by the body's blood vessel cells. Researchers made the confirmation by developing a chemical probe that lights up in reaction to rotten egg gas. The scientists observed the process in real-time through a microscope, said chemist Alexander Lippert, Southern Methodist University, Dallas. "This is going to open up many experiments for scientists," Lippert said.
National Institutes of Health, Packard Foundation, Howard Hughes Medical Institute, Amgen

Contact: Margaret Allen
mallen@smu.edu
214-768-7664
Southern Methodist University

Public Release: 18-Jun-2013
PLOS ONE
UT Dallas study suggests new approach to fight lung cancer
Recent research has shown that cancer cells have a much different -- and more complex -- metabolism than normal cells. Now, scientists at the University of Texas at Dallas have found that exploiting these differences might provide a new strategy to combat lung cancer.
NIH/National Cancer Institute

Contact: Amanda Siegfried
amanda.siegfried@utdallas.edu
972-883-4335
University of Texas at Dallas

Public Release: 17-Jun-2013
Genes & Development
Study identifies protein essential for normal heart function
A study by researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences and the Department of Pharmacology at the University of California, San Diego, shows that a protein called MCL-1, which promotes cell survival, is essential for normal heart function.
National Institutes of Health

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 17-Jun-2013
Surgical Endoscopy
New alternative to surgery lets doctors remove suspicious polyps, keep colon intact
A UCLA team of surgeons and gastroenterologists has been performing a new, minimally invasive procedure to remove large and hard-to-reach polyps while keeping the colon intact. The procedure, which combines two minimally invasive techniques, has currently been performed at only a handful of medical centers in the United States.

Contact: Rachel Champeau
rchampeau@mednet.ucla.edu
310-794-2270
University of California - Los Angeles Health Sciences

Public Release: 17-Jun-2013
Annals of Internal Medicine
Observation is safe, cost-saving in low-risk prostate cancer
Dana-Farber researchers find many men with low-risk, localized prostate cancers can safely choose observation instead of undergoing immediate treatment and a have better quality of life while reducing health care costs.
NIH/National Cancer Institute, US Department of Defense, Prostate Cancer Foundation

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute

Public Release: 17-Jun-2013
ENDO 2013
Preventing eggs' death from chemotherapy
Young women who have cancer treatment often lose their fertility because chemotherapy and radiation can damage or kill their immature ovarian eggs, called oocytes. Now, Northwestern Medicine® scientists have found the molecular pathway that can prevent the death of immature ovarian eggs due to chemotherapy, potentially preserving fertility and endocrine function. Scientists achieved this in mice by adding a currently approved chemotherapy drug, imatinib mesylate, to another chemotherapy drug cisplatin.
NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University

Public Release: 17-Jun-2013
Clinical Oncology
NIH scientists find promising biomarker for predicting HPV-related oropharynx cancer
Researchers have found that antibodies against the human papillomavirus may help identify individuals who are at greatly increased risk of HPV-related cancer of the oropharynx, which is a portion of the throat that contains the tonsils.
NIH/National Cancer Institute

Contact: NCI Press Office
ncipressofficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute

Public Release: 17-Jun-2013
PLOS Genetics
Aspirin may fight cancer by slowing DNA damage
Aspirin is known to lower risk for some cancers, and a new study led by a UC San Francisco scientist points to a possible explanation, with the discovery that aspirin slows the accumulation of DNA mutations in abnormal cells in at least one pre-cancerous condition.

Contact: Jeffrey Norris
jeff.norris@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 17-Jun-2013
Annals of Internal Medicine
OHSU review: Previous studies overstated evidence on Medtronic spinal fusion product
An analysis by the Evidence-based Practice Center at Oregon Health & Science University has found that previously published clinical trial studies about a controversial bone growth product used in spinal surgeries overstated the product's effectiveness.
Yale University Open Data Access

Contact: Todd Murphy
murphyt@ohsu.edu
503-494-8231
Oregon Health & Science University

Public Release: 17-Jun-2013
New England Journal of Medicine
A new target for cancer drug development
Harvard Stem Cell Institute researchers have identified in the most aggressive forms of cancer a gene known to regulate embryonic stem cell self-renewal, beginning a creative search for a drug that can block its activity.

Contact: B. D. Colen
bd_colen@harvard.edu
617-495-7821
Harvard University

Showing releases 251-275 out of 1212.

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