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Showing releases 276-300 out of 1275.

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Public Release: 23-Feb-2015
Nature Genetics
Discovery of the genetic fingerprint of aggressive colon tumors
Scientists are currently developing a test that enables the identification of patients at risk of relapse after surgical removal of a tumor by measuring four to six genes expressed by the tumor microenvironment.

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)

Public Release: 23-Feb-2015
Environmental Health Perspectives
Baby formula poses higher arsenic risk to newborns than breast milk, Dartmouth study shows
In the first US study of urinary arsenic in babies, Dartmouth College researchers found that formula-fed infants had higher arsenic levels than breast-fed infants, and that breast milk itself contained very low arsenic concentrations.

Contact: John Cramer
john.cramer@dartmouth.edu
603-646-9130
Dartmouth College

Public Release: 23-Feb-2015
Proceedings of the National Academy of Sciences
Customized DNA rings aid early cancer detection in mice, Stanford study finds
Stanford University School of Medicine investigators administered a customized genetic construct consisting of tiny rings of DNA, called DNA minicircles, to mice. The scientists then showed that mice with tumors produced a substance that tumor-free mice didn't make. The substance was easily detected 48 hours later by a simple blood test.
Canary Foundation, NIH/National Cancer Institute, Ben and Catherine Ivy Foundation, Sir Peter Michael Foundation

Contact: Bruce Goldman
goldmanb@stanford.edu
650-725-2106
Stanford University Medical Center

Public Release: 23-Feb-2015
Cancer
Certain factors influence whether cancer patients involve family members in treatment decisions
Family members often play an important role in providing care for patients with cancer, but which patients are more or less likely to involve family members in decisions regarding their care is not well known.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
Wiley

Public Release: 23-Feb-2015
Proceedings of the National Academy of Sciences
Small molecule might help reduce cancer in at-risk population, Stanford study finds
Researchers at the Stanford University School of Medicine have found that by changing the selectivity of an enzyme, a small molecule could potentially be used to decrease the likelihood of alcohol-related cancers in an at-risk population.
National Institutes of Health

Contact: Rosanne Spector
manishma@stanford.edu
650-725-5374
Stanford University Medical Center

Public Release: 20-Feb-2015
New England Journal of Medicine
New HPV approved after international phase 2/3 trial involving Moffitt Cancer Center
A pivotal international phase 2/3 clinical trial involving Moffitt Cancer Center faculty demonstrated that vaccination with Gardasil 9 protects against nine HPV types, seven of which cause most cases of cervical, vulvar, and vaginal disease. The trial data indicate that if populations are vaccinated with Gardasil 9 approximately 90 percent of all cervical cancers worldwide can be prevented.
Merck & Co., Inc.

Contact: Kim Polacek
Kim.Polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 20-Feb-2015
Nature Communications
Mayo researchers identify gene that pushes normal pancreas cells to change shape
A research team led by investigators from Mayo Clinic's campus in Jacksonville, Fla., and the University of Oslo, Norway, have identified a molecule that pushes normal pancreatic cells to transform their shape, laying the groundwork for development of pancreatic cancer -- one of the most difficult tumors to treat.
American Association for Cancer Research, National Institutes of Health, Mayo Clinic SPORE for Pancreatic Cancer

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-0746
Mayo Clinic

Public Release: 20-Feb-2015
The Breast
Women back idea of more breast screens for those at high risk of cancer
Most women (85 percent) would back the idea of more frequent breast screening if they are at higher genetic risk of developing breast cancer, according to research published today by The Breast.
Cancer Research UK, The Eve Appeal

Contact: Liz Smith
liz.smith@cancer.org.uk
020-346-98300
Cancer Research UK

Public Release: 20-Feb-2015
Clinical Cancer Research
Palbociclib shows promise in patients with hormone-resistant breast cancer
Palbociclib, an investigational oral medication that works by blocking molecules responsible for cancer cell growth, is well tolerated and extends progression-free survival in newly diagnosed, advanced breast cancer patients, including those whose disease has stopped responding to traditional endocrine treatments.

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine

Public Release: 19-Feb-2015
PLOS Genetics
Insect and mammal ovulation more alike than not?
The average American woman lives more than 80 years and ovulates for 35 of them, producing an egg approximately once a month. The typical fruit fly lives about 4 weeks as an adult and ovulates every 30 minutes. Despite the vast differences, researchers have found that during a key process in ovulation, the same gene may govern both. The results could bring insight to cancer metastasis, human fertility and ovarian disease.
UConn CLAS, Howard Hughes Medical Institute, UConn Holster Scholar and IDEA grant

Contact: Kim Krieger
kim.krieger@uconn.edu
860-486-0361
University of Connecticut

Public Release: 19-Feb-2015
Nature Communications
Cancer risk linked to DNA 'wormholes'
Single-letter genetic variations within parts of the genome once dismissed as 'junk DNA' can increase cancer risk through wormhole-like effects on far-off genes, new research shows. Researchers found that DNA sequences within 'gene deserts' -- so called because they are completely devoid of genes -- can regulate gene activity elsewhere by forming DNA loops across relatively large distances.
European Union, Cancer Research UK, Leukaemia & Lymphoma Research, The Institute of Cancer Research

Contact: Claire Hastings
chastings@icr.ac.uk
020-715-35380
Institute of Cancer Research

Public Release: 19-Feb-2015
JAMA Oncology
BWH study provides evidence for new approaches to prostate cancer
According to the results of a new study conducted at Brigham and Women's Hospital, there is evidence to also support AS as an initial approach for men with favorable intermediate-risk of PC (men with no evidence of the cancer spreading beyond the prostate, a Gleason score of 3+4 or less and PSA, prostate-specific antigen, under 20).

Contact: Elaine St. Peter
estpeter@partners.org
617-525-6375
Brigham and Women's Hospital

Public Release: 19-Feb-2015
Science
Sunlight continues to damage skin in the dark
Much of the damage that ultraviolet radiation does to skin occurs hours after sun exposure, a team of Yale-led researchers concluded in a study that was published online Feb. 19 by the journal Science.
US Department of Defense, National Institutes of Health

Contact: Ziba Kashef
ziba.kashef@yale.edu
203-436-9317
Yale University

Public Release: 19-Feb-2015
Journal of Clinical Investigation
New test to predict the effectiveness of cancer vaccines
Many therapeutic cancer vaccines that are currently being developed are designed to direct the immune system against altered cancer-cell proteins. However, these vaccines can only be effective if the tumor cells present the altered protein to the immune system in a perfectly matching shape. Scientists from the German Cancer Research Center and Heidelberg University Hospital have now described a test to predict whether this prerequisite for effective tumor vaccination is fulfilled.

Contact: Dr. Sibylle Kohlstädt
s.kohlstaedt@dkfz.de
German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)

Public Release: 19-Feb-2015
New England Journal of Medicine
UW research shows sensor technology may help improve accuracy of clinical breast exams
Sensor technology has the potential to significantly improve the teaching of proper technique for clinical breast exams, according to a new study by researchers at the University of Wisconsin School of Medicine and Public Health.
National Institutes of Health

Contact: Gian Galassi
ggalassi@uwhealth.org
608-263-5561
University of Wisconsin-Madison

Public Release: 19-Feb-2015
Cell Reports
Breast cancer spread may be tied to cells that regulate blood flow
Tumors require blood to emerge and spread. That is why scientists at The University of Texas MD Anderson Cancer Center believe that targeting blood vessel cells known as pericytes may offer a potential new therapeutic approach when combined with vascular growth factors responsible for cell death.

Contact: Ron Gilmore
rlgilmore1@mdanderson.org
713-745-1898
University of Texas M. D. Anderson Cancer Center

Public Release: 19-Feb-2015
Nature Communications
New nanogel for drug delivery
MIT chemical engineers have designed a new type of self-healing hydrogel that could be injected through a syringe.
Wellcome Trust, isrock Foundation, Department of Defense, National Institutes of Health

Contact: Sarah McDonnnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology

Public Release: 19-Feb-2015
PLOS ONE
New target for prostate cancer treatment discovered by Keck Medicine of USC researchers
Keck Medicine of the University of Southern California scientists have found a promising new therapeutic target for prostate cancer. The findings offer evidence that a newly discovered member of a family of cell surface proteins called G-protein coupled receptors promotes prostate cancer cell growth.
National Institutes of Health, Robert E. and May R. Wright Foundation

Contact: Leslie Ridgeway
lridgewa@usc.edu
323-442-2823
University of Southern California - Health Sciences

Public Release: 19-Feb-2015
Science
Evolution may hold the key to more designer cancer drugs like Gleevec
Dorothee Kern, a professor of biochemistry and Howard Hughes Medical Institute investigator, unraveled the journey of two closely related cancer-causing proteins -- one susceptible to the drug Gleevec and one not -- over one billion years of evolution. She and her team pinpointed the exact evolutionary shifts that caused Gleevec to bind well with one and poorly with the other. This new approach may have a major impact on the development of rational drugs to fight cancer.
Howard Hughes Medical Institute, Office of Basic Energy Sciences, Catalysis Science Program, US Department of Energy, National Institutes of Health

Contact: Leah Burrows
lburrows@brandeis.edu
781-736-4027
Brandeis University

Public Release: 18-Feb-2015
New England Journal of Medicine
New HPV vaccine offers greater protection against cervical cancer than current vaccine
Scientists have developed a new HPV (human papilloma virus) vaccine which protects against nine types of the virus -- seven of which cause most cases of cervical cancer. The new vaccine offers significantly greater protection than the current vaccine, which protects against only two cancer causing types of HPV.
Merck

Contact: Charli Scouller
c.scouller@qmul.ac.uk
020-788-279-430-770-9825
Queen Mary, University of London

Public Release: 18-Feb-2015
Nature
Researchers unravel health/disease map
Researchers affiliated with several organizations, including Simon Fraser University, have realized a major scientific achievement that will advance understanding of how the information in our cells is used and processed. The scientists are globally celebrating their publication of 20 manuscripts in Nature that describe their generation and analysis of reference epigenome maps. Epigenomes are chemical modifications of DNA and proteins. They cause our genome to stay healthy or develop diseases.
Canadian Institutes of Health Research, National Institutes of Health

Contact: Carol Thorbes
cthorbes@sfu.ca
778-782-3035
Simon Fraser University

Public Release: 18-Feb-2015
Journal of Nuclear Medicine
Research shows value of additional PET/CT scans in follow-up of lung cancer patients
New research from Johns Hopkins School of Medicine reveals a high value of scans which could lead to future change of reimbursement policies for follow-up positron emission tomography/computed tomography studies in lung cancer. The study, featured in the February 2015 issue of the Journal of Nuclear Medicine, establishes the value of fourth and subsequent follow-up PET/CT scans in clinical assessment and management change in patients with the disease.

Contact: Kimberly Brown
kbrown@snmmi.org
703-652-6773
Society of Nuclear Medicine

Public Release: 18-Feb-2015
Journal of Clinical Investigation
Possible strategy identified to combat major parasitic tropical disease
Research led by St. Jude Children's Research Hospital scientists has identified a potential target in the quest to develop a more effective treatment for leishmaniasis, a parasitic tropical disease that kills thousands and sickens more than 1 million people worldwide each year. The findings were published online in the Journal of Clinical Investigation.
National Institutes of Health, European Research Council, Fund for Scientific Research-Flanders, American Lebanese Syrian Associated Charities

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Public Release: 18-Feb-2015
Biochemistry
New insight into a fragile protein linked to cancer and autism
In recent years, scientists have found a surprising a connection between some people with autism and certain cancer patients: They have mutations in the same gene, one that codes for a protein critical for normal cellular health. Now scientists have reported in the ACS journal Biochemistry that the defects reduce the activity and stability of the protein. Their findings could someday help lead to new treatments for both sets of patients.

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

Public Release: 18-Feb-2015
Nature
Predicting cancers' cell of origin
A study led by researchers from Brigham and Women's Hospital suggests a new way to trace cancer back to its cell type of origin. The study, which appears this week in Nature, provides new insights into the early events that shape a cancer, and could have important implications for the many cancer patients for whom the originating site of the cancer is unknown.
National Institutes of Health, Integra-Life Seventh Framework Program, EMBO Young Investigator Program

Contact: Haley Bridger
hbridger@partners.org
617-525-6383
Brigham and Women's Hospital

Showing releases 276-300 out of 1275.

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