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Showing releases 276-300 out of 1367.

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Public Release: 13-Jul-2016
New England Journal of Medicine
Immunotherapy benefits relapsed stem cell transplant recipients
Dana-Farber Cancer Institute study published in the New England Journal of Medicine suggests that using repeated doses of an immunotherapy drug can restore a complete remission for some relapsed stem cell transplant recipients.
National Institutes of Health, NIH/National Cancer Institute Cancer Therapy Evaluation Program, Leukemia & Lymphoma Society Therapy Accelerator Program

Contact: John Noble
johnw_noble@dfci.harvard.edu
617-632-5784
Dana-Farber Cancer Institute

Public Release: 13-Jul-2016
The Allied Genetics Conference
Overcoming barriers in the quest to starve tumors of blood supply
One of the most exciting strategies researchers are pursuing for fighting cancer is to cut off the blood supply of cancerous cells. However, many initially-promising therapies have failed in part because tumor cells counteract these therapies by increasing their production of 'pro-angiogenic' proteins that promote new blood vessel growth and boost tumor blood supply. In a new study, researchers have found a way to turn the tables on this process.

Contact: Andrew Noble
TAGCPress@genetics-gsa.org
Genetics Society of America

Public Release: 13-Jul-2016
The Allied Genetics Conference
First drug target identified for children with rare type of brain tumor
Primitive neuroectodermal tumors are the largest group of malignant brain tumors in children. They can arise from the brain's cerebellum or from tissue located throughout the central nervous system. Little is known about how CNS-PNETs develop, although these tumors are more aggressive than other PNETs and have an overall survival rate of only about 20 percent. In a new study, researchers have identified a possible target for a new CNS-PNET therapy.

Contact: Andrew Noble
TAGCPress@genetics-gsa.org
415-722-2129
Genetics Society of America

Public Release: 13-Jul-2016
Scientific Reports
Simplifying access to gene testing for women with ovarian cancer
A new streamlined approach to genetic testing for women with ovarian cancer provides testing rapidly and affordably, allowing many more patients to benefit from personalized cancer management and their relatives to benefit from cancer prevention strategies.
Wellcome Trust

Contact: Henry French
henry.french@icr.ac.uk
020-715-35582
Institute of Cancer Research

Public Release: 13-Jul-2016
Americans say political candidates are not listening to their health concerns
A strong majority of Americans (81 percent) say medicines available today have improved their quality of life and even more (91 percent) say it is important to develop better medicines for conditions we currently treat, according to a new national public opinion survey commissioned by Research!America. But many respondents say candidates for President and Congress have done a poor job relating to the health expectations of Americans.

Contact: Anna Briseno
abriseno@researchamerica.org
571-482-2737
Research!America

Public Release: 13-Jul-2016
Nature
In the gut, nervous cells are the 'eyes and ears' of the immune system
A team of scientists in Portugal has discovered, in the mouse gut, a novel process that protects the bowel's lining against inflammation and microbial aggressions -- and fights them when they arise. And, most surprisingly, they have shown that this mechanism is under the control of the intestinal nervous system -- the so-called 'second brain.'

Contact: Maria Joao Soares
mjsoares@jlma.pt
351-914-237-487
JLM&A, SA

Public Release: 13-Jul-2016
ACS Central Science
Local drug activation at solid tumor sites
Sarcoma is an aggressive form of cancer responsible for up to 20 percent of childhood cancers. Tumors often first appear in the extremities and the abdomen. Surgery is a primary treatment, but it often is combined with chemotherapy. This week in ACS Central Science, researchers propose a scheme to target chemotherapy medications specifically to sarcomas, leading to greater efficacy and fewer side effects.

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

Public Release: 13-Jul-2016
Journal of Applied Physiology
Fat cells may play key role in battle against breast cancer: York U study
New research led by York University Professor Michael Connor highlights how fat cells could help determine the most effective way to fight breast cancer; including using exercise to combat the disease. For nearly a half century, researchers have studied the links between obesity and breast cancer. This recent study has revealed specifically that adiponectin and leptin are possible reasons for poorer response to therapy and higher risk of death in obese persons than in others.

Contact: Gloria Suhasini
suhasini@yorku.ca
416-736-2100 x22094
York University

Public Release: 13-Jul-2016
Journal of Thoracic Oncology
Nivolumab cost-effectiveness improves by selecting non-squamous NSCLC PD-L1+ patients
Nivolumab (NIV), a checkpoint inhibitor approved for all squamous and non-squamous non-small cell lung cancer (NSCLC) patients in 2015, is not cost-effective when compared to treatment with docetaxel (DOC), chemotherapy medication. However, a Swiss analysis showed the cost-effectiveness of NIV is improved when patients are treated with NIV based on PD-L1 positivity (PD-L1+), or if there is a reduction in dose or drug price.

Contact: Jeff Wolf
Jeff.Wolf@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Public Release: 13-Jul-2016
The Lancet
As overweight and obesity increase, so does risk of dying prematurely
Being overweight or obese is associated with a higher risk of dying prematurely than being normal weight -- and the risk increases with additional pounds, according to a large international collaborative study led by researchers at the Harvard T.H. Chan School of Public Health and the University of Cambridge, UK. The findings contradict recent reports that suggest a survival advantage to being overweight -- the so-called 'obesity paradox.'
National Institutes of Health, UK Medical Research Council, British Heart Foundation, British Heart Foundation Cambridge Cardiovascular Centre of Excellence, UK National Institute for Health Research Cambridge Biomedical Research Centre

Contact: Todd Datz
tdatz@hsph.harvard.edu
617-432-8413
Harvard T.H. Chan School of Public Health

Public Release: 13-Jul-2016
Current Drug Targets
In cancer and aging, interconnected roles for apoptosis and cellular senescence
A new review explores the mechanisms activating cell death and blocking proliferation of mutated cells, with a view towards creating more effective therapies combining both programs.

Contact: Faizan ul Haq
faizan@benthamscience.org
Bentham Science Publishers

Public Release: 13-Jul-2016
Current Cancer Drug Targets
Recent advances in site specific conjugations of antibody drug conjugates
Antibody-drug conjugates take the advantage of antigen specificity of monoclonal antibodies to deliver highly potent cytotoxic drugs selectively to antigen-expressing tumor cells.

Contact: Faizan ul Haq
faizan@benthamscience.org
Bentham Science Publishers

Public Release: 13-Jul-2016
Scientific Reports
A 'key' to metastasis formation
Hokkaido University researchers identified a 'key' molecule that allows tumor cells to break into the bloodstream and form metastases.

Contact: Naoki Namba
pr@oia.hokudai.ac.jp
81-117-068-034
Hokkaido University

Public Release: 12-Jul-2016
Nature Communications
Red hair gene variation drives up skin cancer mutations
For the first time, researchers at the Wellcome Trust Sanger Institute and University of Leeds have proved that gene variants associated with red hair, pale skin and freckles are linked to a higher number of genetic mutations in skin cancers. The burden of mutations associated with these variants is comparable to an extra 21 years of sun exposure in people without this variant.
Cancer Research UK, Wellcome Trust

Contact: Samantha Wynne
press.office@sanger.ac.uk
122-349-2368
Wellcome Trust Sanger Institute

Public Release: 12-Jul-2016
Cancer Letters
As body mass index increases, so does spread of multiple myeloma
In a new study, American University researchers show how, as body mass index increases, so does the growth and spread of the blood cancer multiple myeloma.

Contact: Rebecca Basu
basu@american.edu
202-885-5950
American University

Public Release: 12-Jul-2016
Proceedings of the National Academy of Sciences
Newly discovered features of collagen may help shed light on disease processes
Scientists at the National Institutes of Health are reporting new, unexpected details about the fundamental structure of collagen, the most abundant protein in the human body. In lab experiments, they demonstrated that collagen, once viewed as inert, forms structures that regulate how certain enzymes break down and remodel body tissue. The finding of this regulatory system provides a molecular view of the potential role of physical forces at work in heart disease, cancer, arthritis, and other disease-related processes, they say.

Contact: NHLBI Engagement and Media Relations Branch
nhlbi_news@nhlbi.nih.gov
301-496-5449
NIH/National Heart, Lung and Blood Institute

Public Release: 12-Jul-2016
Oncotarget
Mayo Clinic researchers identify potential immunotherapy drug combination
A drug combination designed to enhance the immune system's ability to zero in and attack cancer cells has shown a pronounced therapeutic effect against advanced and metastatic cancers in mice, according to a Mayo Clinic study, published in the July 12 edition of the online journal Oncotarget.

Contact: Julie Janovsky-Mason
newsbureau@mayo.edu
480-301-6173
Mayo Clinic

Public Release: 11-Jul-2016
Journal of the National Cancer Institute
Familiar history is an important factor for prostate cancer
For the first time, researchers at Umeå University and Lund University have estimated the risk of developing various types of prostate cancer for men with the disease in the family. Men with brothers who have had prostate cancer run twice as high a risk of being diagnosed themselves in comparison to the general population. This according to a study published in the Journal of the National Cancer Institute.

Contact: Daniel Harju
daniel.harju@umu.se
46-725-522-918
Umea University

Public Release: 11-Jul-2016
Cancer
Cancer risk may rise before and immediately after a diabetes diagnosis
A new study indicates that individuals with diabetes may have an elevated risk of developing cancer before and immediately after a diabetes diagnosis. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings point to the need for a better understanding of the link between diabetes and cancer.

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley

Public Release: 11-Jul-2016
Cancer Cell
CNIO researchers describe mechanisms that trigger NASH and liver cancer
Non-alcoholic steatohepatitis (NASH) is a serious hepatic condition that precedes hepatocellular carcinoma (HCC) and is currently untreatable. A study conducted at the Spanish National Cancer Research Centre shows that a proinflammatory molecule, IL-17A, is a key factor in the development of this pathology, and points out that blocking IL-17A with drugs such as digoxin (an antiarrhythmic agent) may be useful to prevent NASH in patients susceptible to develop HCC.
Spanish Ministry of Economy and Competitiveness, European Foundation for the Study of Diabetes, Worldwide Cancer Research

Contact: Nuria Noriega
comunicacion@cnio.es
34-917-328-000
Centro Nacional de Investigaciones Oncológicas (CNIO)

Public Release: 11-Jul-2016
Journal of the National Cancer Institute
New findings concerning hereditary prostate cancer
For the first time ever, researchers have differentiated the risks of developing indolent or aggressive prostate cancer in men with a family history of the disease. Researchers from the Swedish universities of Lund, Uppsala and Umeå now present new and somewhat surprising results.

Contact: Ola Bratt
ola.bratt@med.lu.se
44-798-290-0043
Lund University

Public Release: 11-Jul-2016
Journal of Nuclear Medicine
PET/MRI: A one-stop imaging test to detect prostate cancer?
A University of Michigan study published in the July issue of The Journal of Nuclear Medicine reports that the addition of molecular imaging based on F-18-choline positron emission tomography (PET) improves the identification of significant prostate cancer over multi-parametric prostate magnetic resonance imaging (mpMRI) alone for targeted transrectal prostate biopsies.
Department of Defense, National Institutes of Health, NIH/National Cancer Institute

Contact: Laurie Callahan
lcallahan@snmmi.org
Society of Nuclear Medicine

Public Release: 11-Jul-2016
Chemical Research in Toxicology
Hops extract studied to prevent breast cancer
An enriched hops extract activates a chemical pathway in cells that could help prevent breast cancer, according to new laboratory findings from the UIC/NIH Center for Botanical Dietary Supplements Research at the University of Illinois at Chicago.
NIH Office of Dietary Supplements, National Center for Complementary and Integrative Health

Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago

Public Release: 11-Jul-2016
Gastrointestinal Endoscopy
Study sheds light on true risk for pancreatic cancer in patients with cysts
A look back at more than half a million patient records has established that patients with pancreatic cysts have a significantly higher overall risk of pancreatic cancer compared to those without such cysts, according to a study in the July issue of GIE: Gastrointestinal Endoscopy, the journal of the American Society for Gastrointestinal Endoscopy (ASGE).

Contact: Gina Steiner
gsteiner@asge.org
630-570-5635
American Society for Gastrointestinal Endoscopy

Public Release: 11-Jul-2016
Obstetrics & Gynecology
Preventive procedure for ovarian cancer adopted without adverse surgical outcomes
A surgical procedure recommended to reduce the future risk of ovarian cancer has been successfully implemented throughout Kaiser Permanente in Northern California without a change in surgical outcomes, according to research published today in the journal Obstetrics & Gynecology.
Kaiser Permanente Northern California Residency Program, Kaiser Foundation Hospitals

Contact: Heather Platisha
heather.platisha@creation.io
415-262-5992
Kaiser Permanente

Showing releases 276-300 out of 1367.

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