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Public Release: 17-Jun-2015
PLOS ONE
New biomarkers might help personalize metastatic colorectal cancer treatment
Metastatic colorectal cancer patients tend to live longer when they respond to the first line of chemotherapy their doctors recommend. To better predict how patients will respond to chemotherapy drugs before they begin treatment, researchers at University of California, San Diego School of Medicine conducted a proof-of-principle study with a small group of metastatic colorectal cancer patients. The results revealed two genes that could help physicians make more informed treatment decisions for patients with this disease.
Arthur Athans in the name of his wife, Barbara Mae Athans, National Institutes of Health, Marsha Rivkin Center for Ovarian Cancer Research and Conquer Cancer Foundation of ASCO

Contact: Heather Buschman
hbuschman@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 17-Jun-2015
Science Translational Medicine
New imaging technique could make brain tumor removal safer, more effective, study suggests
Brain surgery is famously difficult for good reason: when removing a tumor, for example, neurosurgeons walk a tightrope as they try to take out as much of the cancer as possible while keeping crucial brain tissue intact -- and visually distinguishing the two is often impossible. Now researchers report they have developed an imaging technology that could provide surgeons with a color-coded map of a patient's brain showing which areas are and are not cancer.
NIH/National Institute of Biomedical Imaging and Bioengineering, NIH/National Institute of Neurological Disorders and Stroke, NIH/National Cancer Institute, Coulter Foundation

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine

Public Release: 17-Jun-2015
JAMA Surgery
Breast-conserving therapy for early-stage cancers has increased, though access an issue
The first comprehensive national review of breast-conserving therapy (BCT) shows that over the last 13 years rates of this treatment modality for early-stage breast cancer have increased at a steady pace. However, the review also highlights important demographic factors that impact which patients have access to BCT.

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center

Public Release: 17-Jun-2015
Cancer Discovery
Tests to gauge genetic risks for prostate cancer now are feasible
Men with an elevated, genetically inherited risk for prostate cancer could be routinely identified with a simple blood or urine test, scientists at UC San Francisco and Kaiser Permanente Northern California have concluded, potentially paving the way to better or earlier diagnosis. The study, which included 7,783 men with prostate cancer and 38,595 without the disease, is available online and will be published in an upcoming issue of the journal Cancer Discovery.
National Institutes or Health, Robert Wood Johnson Foundation, Wayne and Gladys Valley Foundation, Ellison Medical Foundation

Contact: Peter Farley
peter.farley@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 17-Jun-2015
Nature Immunology
Restoring natural immunity against cancers
Scientists at the Institut Pasteur and Inserm have successfully increased the infiltration of immune cells into tumors, thus inducing the immune system to block tumor growth. In an article published in Nature Immunology, the scientists show that, in combination with existing immunotherapies, this process efficiently destroys cancer cells.
Pasteur-Roux Grant, French Cancer League, Fondation ARC Cancer Research Organization, French National Research Agency

Contact: Myriam Rebeyrotte
presse@pasteur.fr
Institut Pasteur

Public Release: 16-Jun-2015
Translational Psychiatry
Early behavior problems may be linked to 'aging' biomarkers in preschoolers
Preschoolers with oppositional defiant behavior are more likely to have shorter telomeres, a hallmark of cellular aging, which in adults is associated with increased risk for chronic diseases and conditions like diabetes, obesity and cancer.
National Institutes of Health, Hellman Family Foundation, Robert Wood Johnson, NASPGHAN Foundation, UCSF CTSI-SOS Award

Contact: Suzanne Leigh
suzanne.leigh@uscf.edu
415-502-6397
University of California - San Francisco

Public Release: 16-Jun-2015
JAMA
World spends more than $200 billion to make countries healthier
The world invested more than $200 billion to improve health in lower-income countries over the past 15 years. Global health financing increased significantly after 2000, when the United Nations established the Millennium Development Goals, which included a strong focus on health. This trend in funding has only recently started to change, according to new research by the Institute for Health Metrics and Evaluation at the University of Washington.

Contact: Rhonda Stewart
stewartr@uw.edu
206-897-2863
Institute for Health Metrics and Evaluation

Public Release: 16-Jun-2015
Journal of Clinical Endocrinology and Metabolism
Prenatal DDT exposure tied to nearly 4-fold increase in breast cancer risk
Women who were exposed to higher levels of the pesticide DDT in utero were nearly four times more likely to be diagnosed with breast cancer as adults than women who were exposed to lower levels before birth, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Contact: Jenni Glenn Gingery
jgingery@endocrine.org
202-971-3655
The Endocrine Society

Public Release: 16-Jun-2015
Cell Stem Cell
Researchers identify new stem cell population important in the growth of colon cancer
Researchers at Lawson Health Research Institute have identified a previously unknown, long-lived radiation-resistant stem cell population in the colon. Most importantly, they also found that these stem cells can give rise to colonic tumors and sustain their growth. The findings, which are published in the prominent journal Cell Stem Cell, will significantly change the way we study and treat colon cancer.

Contact: Julia Capaldi
julia.capaldi@lawsonresearch.com
519-685-8500 x75616
Lawson Health Research Institute

Public Release: 16-Jun-2015
JAMA
Study shows benefit of higher quality screening colonoscopies
An analysis that included information from more than 57,000 screening colonoscopies suggests that higher adenoma detection rates may be associated with up to 50 percent to 60 percent lower lifetime colorectal cancer incidence and death without higher overall costs, despite a higher number of colonoscopies and potential complications, according to a study in the June 16 issue of JAMA.

Contact: Reinier G.S. Meester, M.Sc.
r.meester@erasmusmc.nl
The JAMA Network Journals

Public Release: 16-Jun-2015
Immunotherapy
Adoptive immunotherapy may help treat more types of cancer if new approaches are explored
In a special issue of Immunotherapy, leading experts provide in-depth review of innovative strategies that may further the success of adoptive cell immunotherapy as a cancer treatment.

Contact: Leela Ripton
l.ripton@future-science-group.com
44-208-371-6090
Future Science Group

Public Release: 16-Jun-2015
Cancer Research
Protein plays key role in spread of breast cancer
For breast cancer to be fatal, the tumor has to send out metastases to other parts of the body. The cancer cells are spread via the blood vessels, and a research team at Lund University in Sweden has now proven that the protein ALK1 determines the extent of the tumor's spread in the body. The higher the levels of the protein on the surface of the blood vessels, the greater their permeability to tumor cells and therefore the greater the risk of metastases.

Contact: Kristian Pietras
kristian.pietras@med.lu.se
46-709-209-709
Lund University

Public Release: 16-Jun-2015
European Conferences on Biomedical Optics 2015
Journal of Biomedical Optics
Journal article details 'multiplicity of barriers' to clinical acceptance of medical laser innovations
An article published today in the Journal of Biomedical Optics details obstacles along the path from idea to clinical use of life-saving new medical laser applications. The article appears in a special section titled 'Light for Life' celebrating the International Year of Light and Light-based Technologies 2015 and paralleling a dedicated session at the at the European Conference on Biomedical Optics running June 21-25 in Munich.

Contact: Amy Nelson
amy@spie.org
360-685-5478
SPIE--International Society for Optics and Photonics

Public Release: 16-Jun-2015
Technology
Device allows evaluation of the efficacy, toxicity of drugs metabolized through the liver
Researchers from the Massachusetts General Hospital Center for Engineering in Medicine have developed a novel approach that dramatically simplifies the evaluation of the liver's drug-metabolizing activity and the potential toxic effects of the products of that activity on other organs.
National Institutes of Health

Contact: Noah Brown
nbrown9@partners.org
617-643-3907
Massachusetts General Hospital

Public Release: 16-Jun-2015
Science
New study discovers potential target for tissue regeneration
A new study co-led by Hsin-Hsiung Tai, professor of pharmaceutical sciences at the University of Kentucky, suggests that a key prostaglandin metabolic enzyme shows promise as a drug target to help tissue regeneration and repair, particularly after bone marrow transplantation and tissue injuries.

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky

Public Release: 16-Jun-2015
Journal of Clinical Oncology
Lymph nodes signal more aggressive thyroid cancer even in young patients
Researchers at the Duke Cancer Institute and the Duke Clinical Research Institute have found that younger thyroid cancer patients with lymph node involvement are also at increased risk of dying, contrary to current beliefs and staging prognostic tools that classify young patients as having low-risk disease.

Contact: Sarah Avery
sarah.avery@duke.edu
919-724-5343
Duke University Medical Center

Public Release: 16-Jun-2015
Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research
Drug trials in pet dogs with cancer may speed advances in human oncology
Pet dogs may be humans' best friends in a new arena of life: cancer treatment, said University of Illinois veterinary clinical medicine professor Timothy Fan. Physiological similarities between dogs and humans, and conserved genetics between some dog and human cancers, can allow pet dogs to serve as useful models for studying new cancer drugs, he said.

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign

Public Release: 16-Jun-2015
Immunity
Returning killer T cells back to barracks could improve vaccines
Just as militaries need to have trained, experienced soldiers ready for future wars, making sure that the immune system has enough battle-ready T cells on hand is important for fast-acting, more effective vaccines, according to Penn State researchers.
National Institutes of Health, US Department of Agriculture, American Association of Immunologists

Contact: Matt Swayne
mls29@psu.edu
814-865-9481
Penn State

Public Release: 15-Jun-2015
Cancer Prevention Research
UA researchers discover component of cinnamon prevents colorectal cancer in mice
A study conducted by University of Arizona researchers from the College of Pharmacy and the UA Cancer Center proved that adding cinnamaldehyde, the compound that gives cinnamon its distinctive flavor and smell, to the diet of mice protected the mice against colorectal cancer.
National Institutes of Health, the University of Arizona Cancer Center

Contact: Karin Lorentzen
lorentzen@pharmacy.arizona.edu
520-626-3725
University of Arizona, College of Pharmacy

Public Release: 15-Jun-2015
Nature Genetics
Scientists find genetic variants key to understanding origins of ovarian cancer
New research by an international team including Keck Medicine of USC scientists is bringing the origins of ovarian cancer into sharper focus. The study, published online June 15 in the peer-reviewed journal Nature Genetics, highlights the discovery of three genetic variants associated with mucinous ovarian carcinomas (MOCs), offering the first evidence of genetic susceptibility in this type of ovarian cancer.
European Commission's Seventh Framework Programme grant, Ovarian Cancer Association Consortium, US National Cancer Institute GAME-ON Post-GWAS initiative, American Cancer Society, Canadian Institutes of Health Research

Contact: Leslie Ridgeway
lridgewa@usc.edu
323-442-2823
University of Southern California - Health Sciences

Public Release: 15-Jun-2015
PLOS Pathogens
How the Epstein-Barr virus hides in human cells
Scientists at Helmholtz Zentrum München have now discovered how Epstein-Barr virus (EBV) conceals itself in human cells. A main culprit for its bad visibility by the immune system is the viral protein LMP2A. As published in the scientific journal PLOS Pathogens, the protein helps EBV-infected cells hide from T cells. This camouflage through the LMP2A protein may play a major role in the causation of cancer by EBV.

Contact: Dr. Andreas Moosmann
andreas.moosmann@helmholtz-muenchen.de
49-893-187-1202
Helmholtz Zentrum München - German Research Center for Environmental Health

Public Release: 15-Jun-2015
Journal of Clinical Investigation
'Death-associated protein' promotes cancer growth in most aggressive breast cancers
Although traditionally understood to induce death in cancer cells, researchers at The University of Texas MD Anderson Cancer Center have discovered that the DAPK1 protein is actually essential for growth in breast and other cancers with mutations in the TP53 gene. This discovery indicates DAPK1 may be a promising new therapeutic target for many of the most aggressive cancers.

Contact: Clayton R. Boldt
crboldt@mdanderson.org
713-792-9518
University of Texas M. D. Anderson Cancer Center

Public Release: 15-Jun-2015
Cancer Research
Avocados may hold the answer to beating leukemia
Rich, creamy, nutritious and now cancer fighting. New research reveals that molecules derived from avocados could be effective in treating a form of cancer.
University of Waterloo, Leukemia and Lymphoma Society of Canada

Contact: Nick Manning
nmanning@uwaterloo.ca
226-929-7627
University of Waterloo

Public Release: 15-Jun-2015
Planta
Microbe mobilizes 'iron shield' to block arsenic uptake in rice
University of Delaware researchers have discovered a soil microbe that mobilizes an 'iron shield' to block the uptake of toxic arsenic in rice. The UD finding gives hope that a natural, low-cost solution -- a probiotic for rice plants -- may be in sight to protect this global food source from accumulating harmful levels of one of the deadliest poisons on the planet. Rice currently is a staple in the diet of more than half the world's population.
National Science Foundation

Contact: Andrea Boyle Tippett
aboyle@udel.edu
302-831-1421
University of Delaware

Public Release: 15-Jun-2015
Nature Methods
First full genome of a living organism assembled using technology the size of smartphone
Researchers in Canada and the UK have for the first time sequenced and assembled de novo the full genome of a living organism, the bacteria Escherichia coli, using Oxford Nanopore's MinIONTM device, a genome sequencer that can fit in the palm of your hand.

Contact: Christopher Needles
christopher.needles@oicr.on.ca
416-673-8505
Ontario Institute for Cancer Research

Showing releases 276-300 out of 1365.

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