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Showing releases 301-325 out of 1254.

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Public Release: 3-Aug-2014
Nature Genetics
Tumor suppressor mutations alone don't explain deadly cancer
Although mutations in a gene dubbed 'the guardian of the genome' are widely recognized as being associated with more aggressive forms of cancer, researchers at the University of California, San Diego School of Medicine have found evidence suggesting that the deleterious health effects of the mutated gene may in large part be due to other genetic abnormalities, at least in squamous cell head and neck cancers.
National Institutes of Health, Burroughs Welcome Fund, The American Cancer Society

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 1-Aug-2014
Journal of Clinical Investigation
Pepper and halt: Spicy chemical may inhibit gut tumors
Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin -- the active ingredient in chili peppers -- produces chronic activation of a receptor on cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal tumors.
Crohn's and Colitis Foundation of America, Prins Bernhard Cultural Foundation, Scholten-Cordes Foundation, Dr. Hendrick Muller Vaderlandsch Foundation, Japan Society for the Promotion of Science, the European Molecular Biology Organization

Contact: Michelle Brubaker
mmbrubaker@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 1-Aug-2014
Journal of Clinical Investigation
Study reveals one reason brain tumors are more common in men
New research at Washington University School of Medicine in St. Louis helps explain why brain tumors occur more often in males and frequently are more harmful.

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine

Public Release: 1-Aug-2014
Cancer Research
Recent use of some birth control pills may increase breast cancer risk
Women who recently used birth control pills containing high-dose estrogen and a few other formulations had an increased risk for breast cancer, whereas women using some other formulations did not, according to data published in Cancer Research, a journal of the American Association for Cancer Research.
NIH/National Cancer Institute

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 1-Aug-2014
European Urology
Taking the guesswork out of cancer therapy
Researchers and doctors at A*STAR's Institute of Bioengineering and Nanotechnology, Singapore General Hospital and National Cancer Centre Singapore have co-developed the first molecular test kit that can predict treatment and survival outcomes in kidney cancer patients. This breakthrough was recently reported in European Urology, the world's top urology journal.
Agency for Science, Technology and Research

Contact: Hiroshi Limmell
hiroshi_limmell@a-star.edu.sg
65-947-41738
Biomedical Sciences Institutes (BMSI)

Public Release: 1-Aug-2014
Health Psychology
Expressive writing may help breast cancer survivors
Writing down fears, emotions and the benefits of a cancer diagnosis may improve health outcomes for Asian-American breast cancer survivors, according to a study conducted by a researcher at the University of Houston.
NIH/National Cancer Institute

Contact: Melissa Carroll
mcarroll@uh.edu
713-743-8153
University of Houston

Public Release: 31-Jul-2014
Cell Reports
'Rewired' mice show signs of longer lives with fewer age-related illnesses
While developing a new cancer drug, researchers at The Wistar Institute discovered that mice lacking a specific protein live longer lives with fewer age-related illnesses. The mice, which lack the TRAP-1 protein, demonstrated less age related tissue degeneration, obesity, and spontaneous tumor formation when compared to normal mice. Their findings could change how scientists view the metabolic networks within cells.
NIH/National Cancer Institute, US Department of Defense

Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute

Public Release: 31-Jul-2014
JAMA Otolaryngology - Head & Neck Surgery
Blood and saliva tests help predict return of HPV-linked oral cancers
Physicians at Johns Hopkins have developed blood and saliva tests that help accurately predict recurrences of HPV-linked oral cancers in a substantial number of patients. The tests screen for DNA fragments of the human papillomavirus shed from cancer cells lingering in the mouth or other parts of the body. A description of the development is published in the July 31 issue of JAMA Otolaryngology -- Head & Neck Surgery.
NIH/National Cancer Institute, NIH/National Institute of Dental and Craniofacial Research

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 31-Jul-2014
Cell
Drug target identified for common childhood blood cancer
In what is believed to be the largest genetic analysis of what triggers and propels progression of tumor growth in a common childhood blood cancer, researchers at NYU Langone Medical Center report that they have identified a possible new drug target for treating the disease.

Contact: David March
david.march@nyumc.org
212-404-3528
NYU Langone Medical Center / New York University School of Medicine

Public Release: 31-Jul-2014
New England Journal of Medicine
Transplantation shown to be highly effective in treating immune deficiency in children
Babies who are born with severe combined immunodeficiency can be successfully treated with a transplant of blood-forming stem cells, according to experts led by Memorial Sloan Kettering's Richard J. O'Reilly, M.D.
NIH/National Institute of Allergy and Infectious Diseases, National Institutes of Health

Contact: Courtney DeNicola Nowak
denicolc@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center

Public Release: 31-Jul-2014
Cell
Master HSF supports reprogramming of normal cells to enable tumor growth and metastasi
Long associated with enabling the proliferation of cancer cells, the ancient cellular survival response regulated by Heat-Shock Factor 1 can also turn neighboring cells in their environment into co-conspirators that support malignant progression and metastasis. The finding, reported by Whitehead Institute scientists this week in the journal Cell, lends new insights into tumor biology with significant implications for the diagnosis, prognosis, and management of cancer patients.
NIH/National Cancer Institute, Howard Hughes Medical Institute, V Foundation, Komen Foundation, Human Frontiers Science Program, Fulbright Program, Jared Branfman Sunflowers for Life Fund, Israel National Postdoctoral Award Program for Women in Science

Contact: Matt Fearer
fearer@wi.mit.edu
617-452-4630
Whitehead Institute for Biomedical Research

Public Release: 31-Jul-2014
Human Vaccines & Immunotherapeutics
Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine
A long-term follow-up study shows the sustained efficacy, immunogenicity and safety of GlaxoSmithKline's human papillomavirus vaccine Cervarix. Women vaccinated with the vaccine were followed for more than nine years, and vaccine efficacy against incident infection was 100 percent. This is the longest follow-up report for a licensed human papillomavirus vaccine.

Contact: Andrew Thompson
andrew@landesbioscience.com
Landes Bioscience

Public Release: 31-Jul-2014
Genes and Development
Molecular gate that could keep cancer cells locked up
Researchers from MRC Clinical Sciences Centre and the Brookhaven National Laboratory, N.Y., have revealed the location of a molecular gate on a ring-shaped enzyme that opens up to embrace DNA during the process of cell division. Once the DNA is encircled by the enzyme it begins to unwind its double helix to start a copying process which is integral to cell division.
Medical Research Council, German Research Foundation

Contact: Christian Speck
christian.speck@imperial.ac.uk
44-208-383-3387
MRC Clinical Sciences Centre

Public Release: 30-Jul-2014
Nature
Target growth-driving cells within tumors, not fastest-proliferating cells
A Dana-Farber study shows growth-driving cancer cells may be better targets for therapies than cells that proliferate the fastest within the tumor.
Dana-Farber Cancer Institute Physical Sciences-Oncology Center, CDMRP Breast Cancer Research Program, Cellex Foundation, Deutsche Akademie der Naturforscher Leopoldina, Breast Cancer Research Foundation

Contact: Teresa M. Herbert
teresa_herbert@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute

Public Release: 30-Jul-2014
Cancer
Acupuncture improves quality of life for breast cancer patients using aromatase inhibitors
Use of electroacupuncture (EA) produces significant improvements in fatigue, anxiety and depression in as little as eight weeks for early stage breast cancer patients experiencing joint pain related to the use of aromatase inhibitors to treat breast cancer. The study is the first demonstration of EA's efficacy for both joint pain relief, as well as these other common symptoms.
National Institutes of Health

Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-349-5964
University of Pennsylvania School of Medicine

Public Release: 30-Jul-2014
British Journal of Cancer
Scientists pinpoint bladder cancer patients who could benefit from 'tumor-softening' treatment
Scientists in Manchester have identified a protein that could help doctors decide which bladder cancer patients would benefit from a treatment that makes radiotherapy more effective.
Cancer Research UK

Contact: Flora Malein
flora.malein@cancer.org.uk
44-203-469-8300
Cancer Research UK

Public Release: 30-Jul-2014
Cell Reports
Biologists describe mechanism promoting multiple DNA mutations
The finding that cancer development often involves multiple mutations arising in clusters and in regions where chromosomal rearrangement takes place may one day lead to new cancer therapies.
National Institutes of Health

Contact: Gary Galluzzo
gary-galluzzo@uiowa.edu
319-384-0009
University of Iowa

Public Release: 29-Jul-2014
Current Biology
Researchers uncover secrets of internal cell fine-tuning
New research from scientists at the University of Kent has shown for the first time how the structures inside cells are regulated -- a breakthrough that could have a major impact on cancer therapy development.

Contact: Martin Herrema
M.J.Herrema@kent.ac.uk
01-227-823-581
University of Kent

Public Release: 29-Jul-2014
International Journal of Radiation Oncology, Biology, Physics
Genomic analysis of prostate cancer indicates best course of action after surgery
The study in the postoperative radiation oncology field to show that molecular signature of patient's tumor can help stratify patients requiring additional treatment.

Contact: Edyta Zielinska
edyta.zielinska@jefferson.edu
215-955-5291
Thomas Jefferson University

Public Release: 29-Jul-2014
Nucleic Acids Research
Brazilian researchers identify RNA that regulates cell death
Researchers from the University of Sao Paulo have identified an RNA known as INXS that modulates the action of an important gene in the process of programmed cell death. In experiments on mice, they were able to effect a 10-fold reduction in the volume of subcutaneous malignant tumors. The findings were published in the most recent issue of the journal Nucleic Acids Research.
Sao Paulo Research Foundation, Fundação de Amparo à Pesquisa do Estado de São Paulo

Contact: Samuel Antenor
samuel@fapesp.br
55-113-838-4381
Fundação de Amparo à Pesquisa do Estado de São Paulo

Public Release: 29-Jul-2014
Proceedings of the National Academy of Sciences
Research may explain how foremost anticancer 'guardian' protein learned to switch sides
A cellular program that evolved over eons to heal wounds may have been hijacked by mutant p53 proteins to enable cancers to spread out of control.
Damon Runyon Cancer Research Foundation

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory

Public Release: 29-Jul-2014
PLOS ONE
Penn team makes cancer glow to improve surgical outcomes
The best way to cure most cases of cancer is to surgically remove the tumor. The Achilles heel of this approach, however, is that the surgeon may fail to extract the entire tumor, leading to a local recurrence. With a new technique, researchers at the University of Pennsylvania have established a new strategy to help surgeons see the entire tumor in the patient, increasing the likelihood of a positive outcome.
American Surgical Association, National Institutes of Health

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania

Public Release: 28-Jul-2014
Lancet
New pill regimens published in The Lancet cure hardest-to-treat hepatitis C patients
Today, July 28, 2014, is World Hepatitis Day. Dr. Eric Lawitz, from the University of Texas Health Science Center at San Antonio and the Texas Liver Institute, led a national study that identified a simple, pill-only treatment for hepatitis C that can cure 93 percent of patients in 12 weeks. This replaces a long and complicated treatment with many serious side effects. The study results are published today in The Lancet.
Janssen

Contact: Rosanne Fohn
fohn@uthscsa.edu
210-567-3026
University of Texas Health Science Center at San Antonio

Public Release: 28-Jul-2014
Cell
Stem cell advance may increase efficiency of tissue regeneration
A new stem-cell discovery might one day lead to a more streamlined process for obtaining stem cells, which in turn could be used in the development of replacement tissue for failing body parts, according to UC San Francisco scientists.
California Institute for Regenerative Medicine, National Institutes of Health, UCSF Program for Breakthrough Biomedical Research, Netherlands Organization for Scientific Research, Sontag Foundation

Contact: Jeffrey Norris
jeffrey.norris@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 28-Jul-2014
Proceedings of the National Academy of Sciences
UTSW cancer researchers identify irreversible inhibitor for KRAS gene mutation
UT Southwestern Medical Center cancer researchers have found a molecule that selectively and irreversibly interferes with the activity of a mutated cancer gene common in 30 percent of tumors.
Cancer Research and Prevention Institute of Texas, The Welch Foundation

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Showing releases 301-325 out of 1254.

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