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Showing releases 301-325 out of 1212. << < 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 > >>
Public Release: 13-Jun-2013
 Cancer DiscoveryGenetic variations may help identify best candidates for preventive breast cancer drugs Newly discovered genetic variations may help predict breast cancer risk in women who receive preventive breast cancer therapy with the selective estrogen receptor modulator drugs tamoxifen and raloxifene, a Mayo Clinic-led study has found. The study is published in the journal Cancer Discovery. 
NIH/National Institute of General Medical Science
Contact: Joe Dangor
Public Release: 13-Jun-2013
Cancer DiscoveryNewly identified markers may predict who will respond to breast cancer prevention therapy Genetic variations, known as single nucleotide polymorphisms, in or near the genes ZNF423 and CTSO were associated with breast cancer risk among women who underwent prevention therapy with tamoxifen and raloxifene, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research. Contact: Jeremy Moore
Public Release: 13-Jun-2013
Cell Stem CellMount Sinai researchers succeed in programming blood forming stem cells By transferring four genes into mouse fibroblast cells, researchers at the Icahn School of Medicine at Mount Sinai have produced cells that resemble hematopoietic stem cells, which produce millions of new blood cells in the human body every day. These findings provide a platform for future development of patient-specific stem/progenitor cells, and more differentiated blood products, for cell-replacement therapy. Contact: Renatt Brodsky
Public Release: 12-Jun-2013
Cancer ResearchNanotechnology helps track and improve drug action in pancreatic cancer Scientists from Sydney's Garvan Institute of Medical Research, in collaboration with colleagues from the Beatson Institute for Cancer Research in Glasgow UK, have been able to show ways in which we can markedly improve drug targeting of solid tumors, using tiny 'biosensors' along with new advanced imaging techniques. In real time and in three dimensions, these technologies can show us how cancers spread and how active cancer cells respond to a particular drug.
Cancer Research UK, Australian Research Council, National Health and Medical Research Council, Cancer Institute NSW
Contact: Alison Heather
Public Release: 12-Jun-2013
2013 ASCO Annual MeetingStudy finds greater potential benefit in overall survival for eribulin compared with capecitabine Subgroup analyses from a phase III clinical trial comparing a newer chemotherapy agent called eribulin mesylate, with capecitabine, a standard chemotherapy medication in women with previously treated metastatic breast cancer, showed increased benefit among women sharing certain traits. Specifically, these analyses demonstrated a greater potential benefit in certain subsets of patients with metastatic breast cancer. This analysis was presented by Peter A. Kaufman, M.D., during the 2013 ASCO Annual Meeting. Contact: Donna Dubuc
Public Release: 11-Jun-2013
JAMAVery high prevalence of chronic health conditions among adult survivors of childhood cancer In an analysis that included more than 1,700 adult survivors of childhood cancer, researchers found a very high percentage of survivors with 1 or more chronic health conditions, with an estimated cumulative prevalence of any chronic health condition of 95 percent at age 45 years, according to a study in the June 12 issue of JAMA. Contact: Summer Freeman
Public Release: 11-Jun-2013
JAMAChildhood cancer survivors found to have significant undiagnosed disease as adults St. Jude Children's Research Hospital has found that childhood cancer survivors overwhelmingly experience a significant amount of undiagnosed, serious disease through their adult years, establishing the importance of proactive, life-long clinical health screenings for this growing high-risk population.
NIH/National Cancer Institute, American-Lebanese-Syrian Associated Charities
Contact: Summer Freeman
Public Release: 11-Jun-2013
Health PsychologyTelephone counseling plus physician advice key to motivating breast cancer survivors to exercise Miriam Hospital researchers say telephone-based counseling, when combined with physician advice, can help breast cancer survivors become more physically active, improving quality of life and lessening the side effects of cancer treatment.
American Cancer Society
Contact: Jessica Collins Grimes
Public Release: 11-Jun-2013
Cancer CellDiabetes drug points the way to overcoming drug resistance in melanoma Despite the success of melanoma-targeting drugs, tumors inevitably become drug resistant and return, more aggressive than before. In the current issue of the journal Cancer Cell, however, researchers at The Wistar Institute describe how they increase the effectiveness of anti-melanoma drugs by combining anticancer therapies with diabetes drugs. Their studies, conducted in cell and animal models of melanoma, demonstrate that the combined therapy could destroy a subset of drug-resistant cells within a tumor.
National Institutes of Health
Contact: Greg Lester
Public Release: 11-Jun-2013
Journal of Clinical OncologyStudy finds cancer guidelines do not fully meet IOM standards Researchers at the University of Michigan Comprehensive Cancer Center looked at 169 cancer clinical practice guidelines and found that none of the guidelines fully met standards set in 2011 by the Institute of Medicine. Contact: Nicole Fawcett
Public Release: 11-Jun-2013
Molecular CellScripps Research Institute scientists uncover new details of natural anticancer mechanism Scientists at The Scripps Research Institute have identified key triggers of an important cancer-blocking mechanism in cells. Termed "oncogene-induced senescence," this mechanism can block most cancer types and is commonly experienced when incipient skin cancers turn instead into slow-growing moles. Tumors that achieve malignancy often do so by defeating or circumventing this growth barrier -- which is why scientists have been eager to find out precisely how it works.
National Institutes of Health
Contact: Mika Ono
Public Release: 11-Jun-2013
Journal of Women's HealthDo women know which lifestyle choices may affect cancer risk? A multifaceted new survey determined how women view diet and exercise in relationship to cancer and whether they believe they are engaging in healthy behaviors, and whether their diet and exercise choices really meet the minimum recommendations. Contact: Vicki Cohn
Public Release: 10-Jun-2013
Supportive Care in CancerQuality-of-life issues need to be addressed for CML patients, Moffitt researchers say Researchers at Moffitt Cancer Center have determined that chronic myeloid leukemia patients who are treated with a class of oral chemotherapy drugs known as a tyrosine kinase inhibitors have significant side effects and quality-of-life issues that need to be addressed. Some of these issues include depression, fatigue, nausea and change of appearance. The researchers say it is important to improve the patients' quality of life because most will take tyrosine kinase inhibitors for the rest of their lives. Contact: Kim Polacek
Public Release: 10-Jun-2013
Journal of Clinical InvestigationEpigenetic factor likely plays a key role in fueling most common childhood cancer Changes in an epigenetic mechanism that turns expression of genes on and off may be as important as genetic alterations in causing pediatric acute lymphoblastic leukemia, according to a study led by scientists at St. Jude Children's Research Hospital and published in the June 10 online edition of the Journal of Clinical Investigation.
American Lebanese Syrian Associated Charities
Contact: Carrie Strehlau
Public Release: 10-Jun-2013
Proceedings of the National Academy of SciencesShape of nanoparticles points the way toward more targeted drugs A new study involving Sanford-Burnham's Erkki Ruoslahti, M.D., Ph.D., contributing to work by Samir Mitragotri, Ph.D., at the University of California, Santa Barbara, found that the shape of nanoparticles can enhance drug targeting. The study found that rod-shaped nanoparticles -- or nanorods -- as opposed to spherical nanoparticles, appear to adhere more effectively to the surface of endothelial cells that line the inside of blood vessels. Contact: Deborah Robison
Public Release: 10-Jun-2013
PhytomedicineSubstances from African medicinal plants could help stop tumor growth African medicinal plants contain chemicals that may be able to stop the spread of cancer cells. This is the conclusion of researchers following laboratory experiments conducted at Johannes Gutenberg University Mainz. Contact: Dr. Thomas Efferth
Public Release: 10-Jun-2013
Journal of Radiation OncologyBiodegradable implant may lessen side effects of radiation to treat prostate cancer Several years ago, VCU Massey Cancer Center became the first center in the US to test an Israeli-invented device designed to increase the space between the prostate and the rectum in prostate cancer patients undergoing radiation therapy. Now, results from the international Phase I clinical trial show that the device has the potential to significantly reduce rectal injury, a side effect caused by unwanted radiation exposure that can leave men with compromised bowel function following treatment.
NIH/National Cancer Institute
Contact: John Wallace
Public Release: 10-Jun-2013
Cancer CellUni Basel researchers discover master regulator in cancer metastasis In the process of metastasis, the movement of cancer cells to different parts of the body, a specific master regulator gene plays a central role: a transcription factor named Sox4 activates a sequence of genes and triggers the formidable process. This finding is reported by researchers from the University of Basel and from the Friedrich Miescher Institute in Cancer Cell. Inhibition of Sox4 and subsequent processes may prevent metastasis in cancer patients.
Swiss National Science Foundation, Swiss Initiative for Systems Biology
Contact: Anne Zimmermann
Public Release: 10-Jun-2013
Cancer ResearchHormonal treatment for endometrial cancer does not directly target the malignant cells Rogesterone, a female hormone that can be used as a therapy for endometrial cancer, eliminates tumor cells indirectly by binding to its receptor in connective tissue cells residing in the tumor microenvironment.
Charles Drew University, University of California, Los Angeles National Institutes of Health, Sidney Kimmel Foundation
Contact: Kim Irwin
Public Release: 10-Jun-2013
SNMMI 2013 Annual Meeting Journal of Nuclear MedicineBreast cancer: PET and MR predict chemotherapy's ability to prolong life For patients with advanced breast cancer, positron emission tomography and magnetic resonance imaging can improve quality of life and survival by providing physicians with information on the effectiveness of chemotherapy prior to surgery, say researchers presenting at the 2013 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging. Contact: Susan Martonik
Public Release: 10-Jun-2013
SNMMI 2013 Annual Meeting Journal of Nuclear MedicinePET/MR effective for imaging recurrent prostate cancer A relatively new imaging system that simultaneously combines positron emission tomography and magnetic resonance demonstrates a higher capacity for mapping recurrent prostate cancer than the already high standard of integrated PET and computed tomography, say researchers presenting a study at the Society of Nuclear Medicine and Molecular Imaging's 2013 Annual Meeting. Contact: Susan Martonik
Public Release: 10-Jun-2013
SNMMI 2013 Annual Meeting Journal of Nuclear MedicineMolecular imaging enlists prostate enzyme to detect metastases No matter where they have hidden, metastatic prostate cancer cells still express some of the same signaling as normal prostate cells; in some cases even more so, as with the PSMA enzyme. Harnessing this enzyme could mean the beginning of a new platform for prostate cancer detection, staging, treatment and post-treatment monitoring, say researchers at the Society of Nuclear Medicine and Molecular Imaging's 2013 Annual Meeting. Contact: Susan Martonik
Public Release: 10-Jun-2013
SNMMI 2013 Annual Meeting Journal of Nuclear MedicineSoftware toolkit shapes models for personalized radionuclide therapy Technology providing a means of patient-specific radionuclide drug therapies has not been standardized, as it has been limited to software that requires oncologists to manually define the areas of tumors. A new "phantom" model of the human form that can be deformed and reformed to match anatomy in a matter of hours using 3-D graphic design software is being combined with a precision method for predicting how radionuclide therapies interact with tissues to determine the most effective cancer-killing dose for every patient. Contact: Susan Martonik
Public Release: 10-Jun-2013
SNMMI 2013 Annual Meeting Journal of Nuclear MedicineMolecular imaging improves care for children with brain cancer A relatively new weapon in the fight against childhood brain cancer has emerged that improves upon standard magnetic resonance imaging by providing information about tumor metabolism and extent of cancer in children diagnosed with glioma, a growth caused by the abnormal division of glial cells in the brain, say researchers at the Society of Nuclear Medicine and Molecular Imaging's 2013 Annual Meeting. Contact: Susan Martonik
Public Release: 10-Jun-2013
Proceedings of the National Academy of SciencesA path to lower-risk painkillers Could we be on the way to creating painkillers without side effects?
National Institutes of Health
Contact: Beata Mostafavi
Showing releases 301-325 out of 1212. << < 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 > >>
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