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Showing releases 51-75 out of 1286.

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Public Release: 24-Jul-2014
PLOS Computational Biology
Gene changes in breast cancer cells pinpointed with new computational method
Computer scientists at Carnegie Mellon University, working with high-throughput data generated by breast cancer biologists at Lawrence Berkeley National Laboratory, have devised a computational method to determine how gene networks are rewired as normal breast cells turn malignant and as they respond to potential cancer therapy agents.
NIH/National Institute of General Medical Sciences, NIH/National Cancer Institute, DOE/Breast Cancer Research Program

Contact: Byron Spice
bspice@cs.cmu.edu
412-268-9068
Carnegie Mellon University

Public Release: 24-Jul-2014
PLOS ONE
Researchers discover new way to determine cancer risk of chemicals
A new study has shown that it is possible to predict long-term cancer risk from a chemical exposure by measuring the short-term effects of that same exposure. The findings, which currently appear in the journal PLOS ONE, will make it possible to develop simpler and cheaper tests to screen chemicals for their potential cancer causing risk.
National Institutes of Health, Evans Center for Interdisciplinary Biomedical Research

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center

Public Release: 24-Jul-2014
JAMA Otolaryngology -- Head & Neck Surgery
Increased risk for head, neck cancers in patients with diabetes
Diabetes mellitus appears to increase the risk for head and neck cancer.
Taipei Medical University, Chi Mei Medical Center Research Fund

Contact: Yung-Song Li
kingear@gmail.com
The JAMA Network Journals

Public Release: 23-Jul-2014
JAMA Dermatology
Research led by Temple's chair of dermatology: Pain and itch may be signs of skin cancer
Asking patients if a suspicious skin lesion is painful or itchy may help doctors decide whether the spot is likely to be cancerous, according to a new study headed by Gil Yosipovitch, M.D., Chairman of the Department of Dermatology at Temple University School of Medicine. The study, published online by JAMA Dermatology on July 23, 2014, found that nearly 36.9 percent of skin cancer lesions are accompanied by itching, while 28.2 percent involve pain.
Comprehensive Cancer Center at Wake Forest

Contact: Jeremy Walter
Jeremy.Walter@tuhs.temple.edu
267-838-0398
Temple University Health System

Public Release: 23-Jul-2014
Nature
Genetics of cancer: Non-coding DNA can finally be decoded
Cancer is a disease of the genome resulting from a combination of genetic modifications, or mutations. We inherit from our parents strong or weak predispositions to developing certain kinds of cancer; in addition, we also accumulate new mutations in our cells throughout our lifetime. Although the genetic origins of cancers have been studied for a long time, researchers were not able to measure the role of non-coding regions of the genome until now.

Contact: Emmanouil Dermitzakis
emmanouil.dermitzakis@unige.ch
Université de Genève

Public Release: 23-Jul-2014
Nature
New view of stomach cancer could hasten better therapies
In a massive effort to catalog the molecular causes of stomach cancer, scientists, including researchers at Dana-Farber Cancer Institute, have identified four subtypes of tumors based on shared mutations and other molecular abnormalities. They say the new classification promises to advance clinical research to develop improved therapies for the third-leading cancer killer worldwide.
National Institutes of Health

Contact: Anne Doerr
anne_doerr@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute

Public Release: 23-Jul-2014
British Journal of Cancer
No increased risk of cancer near Sellafield or Dounreay in recent years
Children, teenagers and young adults living near Sellafield or Dounreay since the 1990s are not at an increased risk of developing cancer according to research published in the British Journal of Cancer today.
Department of Health's Radiation Protection Research Programme

Contact: Alan Worsley
alan.worsley@cancer.org.uk
020-346-98252
Cancer Research UK

Public Release: 23-Jul-2014
Nature
New regions of genetic material are involved in the development of colon cancer
Most research on human cancer genes have been focused on regions of the coding genome, but just before each gene, there is a regulatory region which controls the expression and activity of the adjacent gene. Until now, very little was known of the role exerted such DNA fragment in tumor development. An article published today in Nature in collaboration with the group of Manel Esteller shows that these regions are also altered in cancer.

Contact: Arantxa Mena
amena@idibell.cat
0034-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 23-Jul-2014
Reproductive Biology and Endocrinology
Hormones after breast cancer: Not fuel for the fire after all?
Study highlights beneficial effects of non-oral hormone therapy on cardiac and bone outcomes, tumor reduction, and overall health in postmenopausal breast cancer mouse model.
Parsemus Foundation

Contact: Elaine Lissner
pr@parsemusfoundation.org
415-839-6304
Parsemus Foundation

Public Release: 23-Jul-2014
Stem Cells and Development
New method for reducing tumorigenicity in induced pluripotent stem-cell based therapies
The potential for clinical use of induced pluripotent stem cell (iPSC) technology for transplant-based therapeutic strategies has previously been hindered by the risk of dysregulated cell growth, specifically the development of tumors.

Contact: Kathryn Ruehle
kruehle@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 23-Jul-2014
Nature Genetics
Vanderbilt-led study identifies genes linked to breast cancer in East Asian women
A new study in East Asian women has identified three genetic changes linked to an increased risk of breast cancer. The research, led by Vanderbilt University investigators, was published in Nature Genetics.
National Institutes of Health, Department of Defense, Vanderbilt-Ingram Cancer Center

Contact: Dagny Stuart
dagny.stuart@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center

Public Release: 22-Jul-2014
International Journal of Cancer
Viral therapy could boost limb-saving cancer treatment
Viruses designed to target and kill cancer cells could boost the effectiveness of chemotherapy to the arms and legs and help avoid amputation, a new study reports.

Contact: Graham Shaw
graham.shaw@icr.ac.uk
020-715-35380
Institute of Cancer Research

Public Release: 22-Jul-2014
JAMA
Study examines presence of uterine cancers at the time of hysterectomy using morcellation
Among women undergoing a minimally invasive hysterectomy using electric power morcellation, uterine cancers were present in 27 per 10,000 women at the time of the procedure, according to a study published by JAMA. There has been concern that this procedure, in which the uterus is fragmented into smaller pieces, may result in the spread of undetected malignancies.

Contact: Lucky Tran
cumcnews@columbia.edu
The JAMA Network Journals

Public Release: 22-Jul-2014
PLOS ONE
New research finds pathogenic connection between autoimmune disorders and cancer
Autoimmune disorders may share certain pathogenic mechanisms with cancer, according to a new report published in PLOS ONE by Linda Kusner, Ph.D., assistant research professor in the Department of Pharmacology and Physiology at the George Washington University School of Medicine and Health Sciences.

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University

Public Release: 22-Jul-2014
Oral Oncology
Anti-pain agent shrinks oral cancers, leaves healthy tissues alone
Oral cancers strike thousands of Americans annually, inflicting pain and shortening their lives. New research out of the University of Texas Health Science Center at San Antonio showed that an agent called capsazepine reduced the oral tumors in mice without damaging surrounding tissues. It's a hopeful start with more work to go.
National Institutes of Health, American Cancer Society

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio

Public Release: 22-Jul-2014
Cancer Cell
Research brings us nearer to understanding how neuro cells turn cancerous
Scientists from the Sloan-Kettering Institute for Cancer Research in New York with the help of Plymouth University Peninsula Schools of Medicine and Dentistry have completed research which for the first time brings us nearer to understanding how some cells in the brain and nervous system become cancerous.

Contact: Andrew Gould
andrew.gould@plymouth.ac.uk
University of Plymouth

Public Release: 22-Jul-2014
JAMA
HIV clinic-based audio project emphasizes the power of patient voices
The St. Jude Children's Research Hospital VOICES project is the focus of the 'A Piece of My Mind' column in the July 22 edition of the Journal of the American Medical Association. The project uses contemporary technology to tap an ancient and powerful clinical tool -- the patient's own story -- as a way to empower and inspire patients, teach empathy and improve health care.

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Public Release: 21-Jul-2014
Journal of Biological Education
Described novel regulator of a protein inactive in over 50 percent of human tumors
Researchers at the Bellvitge Biomedical Research Institute and the University of Barcelona have discovered the interaction between HERC2 proteins with another protein called p53 that is inactivated in more than half of human tumors. The study results were published in the Journal of Biological Chemistry.

Contact: Arantxa Mena
amena@idibell.cat
0034-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 21-Jul-2014
Canadian Medical Association Journal
Advanced cancer patients can benefit from programs combining exercise, nutrition
Patients with advanced cancer can benefit from a rehabilitation program combining exercise, nutritional counselling and symptom control, according to an evidence review in the Canadian Medical Association Journal. Palliative care programs should be expanded to include these elements and should be available to patients from diagnosis.

Contact: Kim Barnhardt
kim.barnhardt@cmaj.ca
613-520-7116 x2224
Canadian Medical Association Journal

Public Release: 21-Jul-2014
Nature
Vanderbilt discovery may advance colorectal cancer diagnosis and treatment
A Vanderbilt University-led research team has identified protein 'signatures' of genetic mutations that drive colorectal cancer, the nation's second leading cause of cancer deaths after lung cancer.
National Institutes of Health

Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center

Public Release: 21-Jul-2014
Journal of Bacteriology
Investigators identify genes that contribute to radiation resistance
A team of researchers from the University of Wisconsin have identified 46 genes in Escherichia coli that are necessary for its survival at exceptionally high levels of radiation. The paper appears ahead of print in the Journal of Bacteriology.

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology

Public Release: 21-Jul-2014
Journal of Thoracic Oncology
ROS1 gene fusions are found in 2.4 percent of Asian patients with lung adenocarcinoma
ROS1 fusion genes were successfully detected independent of gender or smoking history in young East Asian patients with lung adenocarcinoma, a histological subgroup in non-small cell lung cancer, using multiplex reverse transcriptase-polymerase chain reaction and immunohistochemistry diagnostic tests.

Contact: Rob Mansheim
rob.mansheim@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Public Release: 21-Jul-2014
Translational Oncology
Unique study focuses on combined treatment approach for locally advanced pancreatic cancer
Investigators at the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute are developing a novel, multistep investigational treatment for one of the most complex and difficult-to-treat forms of the disease, locally advanced pancreatic cancer.
PHASE ONE, Diane V. Allen

Contact: Cara Martinez
cara.martinez@cshs.org
310-423-7798
Cedars-Sinai Medical Center

Public Release: 21-Jul-2014
Journal of Urology
New accurate epigenetic test could eliminate unnecessary repeat biopsies for prostate cancer
More than one million prostate biopsies are performed each year in the US alone, including many repeat biopsies for fear of cancer missed. Therefore there is a need to develop diagnostic tests that will help avoid unnecessary repeat biopsies. Two independent trials have now validated the performance of an epigenetic test that could provide physicians with a better tool to help eliminate unnecessary repeat prostate biopsies, report investigators in the Journal of Urology.

Contact: Linda Gruner
e.leahy@elsevier.com
212-633-3923
Elsevier Health Sciences

Public Release: 21-Jul-2014
Journal of Thoracic Oncology
Increased overall survival for advanced stage non-small cell lung cancer patients is associated with availability of less toxic chemotherapy
A 10-year population-based study shows that increased availability of better systemic chemo- and targeted-therapies for patients with advanced non-small cell lung cancer coincides with increased usage of these therapies. This in turn leads to a significant increase in overall survival.

Contact: Rob Mansheim
rob.mansheim@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Showing releases 51-75 out of 1286.

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