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Showing releases 51-75 out of 1224.

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Public Release: 4-Sep-2014
Cell
The newest precision medicine tool: Prostate cancer organoids
Research led by investigators at Memorial Sloan Kettering Cancer Center has shown for the first time that organoids derived from human prostate cancer tumors can be grown in the laboratory, giving researchers an exciting new tool to test cancer drugs and personalize cancer treatment.
Stand Up To Cancer-Prostate Cancer Foundation Prostate Dream Team Translational Cancer Research Grant, National Institutes of Health, US Department of Defense, Movember Foundation, Geoffrey Beene Cancer Research Center

Contact: Andrea Baird
bairda@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center

Public Release: 4-Sep-2014
Journal of the National Cancer Institute
Soy supplementation adversely effects expression of breast cancer-related genes
Soy supplementation alters expression of genes associated with breast cancer, raising concerns that soy could have adverse effects in breast cancer, according to a new study published Sept. 4 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
Zachary.Rathner@oup.com
919-677-2697
Oxford University Press USA

Public Release: 4-Sep-2014
Breast Cancer Symposium 2014
Breast conserving therapy shows survival benefit compared to mastectomy in early-stage patients
When factoring in what is now known about breast cancer biology and heterogeneity, breast conserving therapy may offer a greater survival benefit over mastectomy to women with early stage, hormone-receptor positive disease, according to research from The University of Texas MD Anderson Cancer Center.

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center

Public Release: 4-Sep-2014
Breast Cancer Symposium 2014
Breast radiation trial provides more convenience, better compliance, lowered cost
An experimental regimen of once-weekly breast irradiation following lumpectomy provides more convenience to patients at a lower cost, results in better completion rates of prescribed radiation treatment, and produces cosmetic outcomes comparable to the current standard of daily radiation.

Contact: Jill Scoggins
jill.scoggins@louisville.edu
502-852-7461
University of Louisville

Public Release: 4-Sep-2014
Cell Reports
Study identifies gene network behind untreatable leukemia and possible treatment target
Researchers have identified a genetic/molecular network that fuels a high-risk and aggressive form of acute myeloid leukemia and its precursor disease myelodysplastic syndrome -- providing a possible therapeutic strategy for an essentially untreatable form of the blood cancer. Scientists from the Cancer and Blood Diseases Institute at Cincinnati Children's Hospital Medical Center report their results in a study posted online Sept. 4 by Cell Reports.
Cincinnati Children's Hospital Research Foundation, American Society of Hematology, National Institutes of Health, Department of Defense, NIH/National Institute of Diabetes, Digestive and Kidney Diseases

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center

Public Release: 4-Sep-2014
Breast Cancer Symposium 2014
Disparities persist in early-stage breast cancer treatment, MD Anderson study finds
Despite its acceptance as standard of care for early stage breast cancer almost 25 years ago, barriers still exist that preclude patients from receiving breast conserving therapy, with some still opting for a mastectomy, according to research from The University of Texas MD Anderson Cancer Center.

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center

Public Release: 4-Sep-2014
New England Journal of Medicine
Phase III FIRST (MM-020/IFM 07-01) trial of REVLIMID (lenalidomide) plus dexamethasone in newly diagnosed multiple myeloma patients who are not candidates for stem cell transplant published in New England Journal of Medicine
The study met the primary endpoint as a significant progression-free survival benefit was seen for patients treated with continuous REVLIMID plus dexamethasone compared with those treated with a standard of care.
Intergroupe Francophone du Myélome, Celgene

Contact: Celgene Corporation
media@celgene.com
908-673-2275
Celgene Corporation

Public Release: 4-Sep-2014
Nature Biotechnology
Most accurate measures of gene expression
RNA-sequencing data analysis method BitSeq developed by Academy Research Fellow Antti Honkela's, Univeristy of Helsinki, research group and University of Manchester researchers has been found to be the most accurate gene transcript expression estimation method in a large international assessment. The method is based on probabilistic modelling which can capture the uncertainty related to the measurements.

Contact: Antti Honkela
antti.honkela@hiit.fi
University of Helsinki

Public Release: 3-Sep-2014
New England Journal of Medicine
Blood test for 'nicked' protein predicts prostate cancer treatment response
Prostate cancer patients whose tumors contain a shortened protein called AR-V7, which can be detected in the blood, are less likely to respond to two widely used drugs for metastatic prostate cancer, according to results of a study led by researchers at the Johns Hopkins Kimmel Cancer Center.
Prostate Cancer Foundation, US Department of Defense, NIH/National Cancer Institute

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 3-Sep-2014
JAMA Dermatology
Airline pilots, cabin crews have higher incidence of melanoma
Airline pilots and cabin crews appear to have twice the incidence of melanoma as the general population.

Contact: Elizabeth Fernandez
Elizabeth.Fernandez@UCSF.edu
415-514-1592
The JAMA Network Journals

Public Release: 3-Sep-2014
Journal of the National Cancer Institute
Genetic 'hotspot' linked to endometrial cancer aggressiveness
Scientists at The University of Texas MD Anderson Cancer Center in Houston have identified genetic mutations in endometrioid endometrial carcinoma, the most common form of this cancer of the uterine lining.

Contact: Ron Gilmore
rlgilmore1@mdanderson.org
713-745-1898
University of Texas M. D. Anderson Cancer Center

Public Release: 3-Sep-2014
Nature Communications
CNIO experts discover the genomic origin of telomere protectors
A study led by Centro Nacional de Investigaciones Oncologicas researchers has discovered that telomeric repeat-containing RNA do not originate in all telomeres that protect the 20 murine chromosomes, but do exclusively in chromosome 18 and, to a lesser extent, in chromosome 9. This peculiarity sets the stage for future genetic manipulation in mice with the aim of researching the in vivo role of these molecules in telomere biology and in illness. The results have been published in Nature Communications.
Ministry of Economy and Competitiveness, Community of Madrid, European Union, Lilly Foundation, Fundación Botín, AXA Research Fund

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 3-Sep-2014
ACS Nano
Handheld scanner could make brain tumor removal more complete, reducing recurrence
Cancerous brain tumors are notorious for growing back despite surgical attempts to remove them -- and for leading to a dire prognosis for patients. But scientists are developing a new way to try to root out malignant cells during surgery so fewer or none get left behind to form new tumors. The method, reported in the journal ACS Nano, could someday vastly improve the outlook for patients.

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society

Public Release: 3-Sep-2014
PLOS Pathogens
Leaky gut -- A source of non-AIDS complications in HIV-positive patients
Human immunodeficiency virus infection is no longer a fatal condition, thanks to newer medications inhibiting the retrovirus, but a phenomenon has surfaced among these patients -- non-AIDS complications. Scientists at Case Western Reserve University School of Medicine have resolved the mystery with their discovery of the leaky gut as the offender. Bacterial products seep out of the colon, trigger inflammation and set off the processes of cardiovascular, neurodegenerative, chronic kidney and metabolic diseases, and cancer.
National Institutes of Health

Contact: Jeannette Spalding
jeannette.spalding@case.edu
216-368-3004
Case Western Reserve University

Public Release: 3-Sep-2014
Cell
Innovative algorithm spots interactions lethal to cancer
An ideal anti-cancer treatment -- one that's immediately lethal to cancer cells, harmless to healthy cells, and resistant to cancer's relapse -- is still a dream. New research from Tel Aviv University takes a step closer to the realization of that dream with an innovative computer algorithm that spots cancer-busting 'genetic partners' whose interactions are lethal to cancer cells.

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University

Public Release: 2-Sep-2014
JAMA
Increase seen in use of double mastectomy
Among women diagnosed with early-stage breast cancer in California, the percentage undergoing a double mastectomy increased substantially between 1998 and 2011, although this procedure was not associated with a lower risk of death than breast-conserving surgery plus radiation, according to a study in the Sept. 3 issue of JAMA. The authors did find that surgery for the removal of one breast was associated with a higher risk of death than the other options examined in the study.

Contact: Jana Cuiper
Jana.Cuiper@cpic.org
510-608-5160
The JAMA Network Journals

Public Release: 2-Sep-2014
Applied Physics Letters
New method for non-invasive prostate cancer screening
A team of researchers led by Shaoxin Li at Guangdong Medical College in China has demonstrated the potential of a new, non-invasive method to screen for prostate cancer, a common type of cancer in men worldwide. They describe their laboratory success testing an existing spectroscopy technique called surface-enhanced Raman scattering with a new, sophisticated analysis technique called support vector machine.

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
American Institute of Physics

Public Release: 2-Sep-2014
JAMA
Breast cancer patients with bilateral mastectomy don't have better survival rates
Breast cancer patients treated with lumpectomy followed by radiation therapy survived as long as patients who had bilateral mastectomy, according to a large study conducted by researchers at the Stanford University School of Medicine and the Cancer Prevention Institute of California.

Contact: Krista Conger
kristac@stanford.edu
650-725-5371
Stanford University Medical Center

Public Release: 2-Sep-2014
BMC Veterinary Research
Global snapshot of infectious canine cancer shows how to control the disease
While countries with dog control policies have curbed an infectious and gruesome canine cancer, the disease is continuing to lurk in the majority of dog populations around the world, particularly in areas with many free-roaming dogs. This is according to research published in the open-access journal BMC Veterinary Research.

Contact: Shane Canning
shane.canning@biomedcentral.com
44-020-319-22243
BioMed Central

Public Release: 2-Sep-2014
Nature Scientific Reports
Sabotage as therapy: Aiming lupus antibodies at vulnerable cancer cells
Yale Cancer Center researchers may have discovered a new way of harnessing lupus antibodies to sabotage cancer cells made vulnerable by deficient DNA repair. The study, led by James E. Hansen, M.D., assistant professor of therapeutic radiology at Yale School of Medicine, found that cancer cells with deficient DNA repair mechanisms (or the inability to repair their own genetic damage) were significantly more vulnerable to attack by lupus antibodies.
American Cancer Society Institutional Research Grant

Contact: Vicky Agnew
203-785-7001
Yale University

Public Release: 2-Sep-2014
Proceedings of the National Academy of Sciences
Enzyme controlling metastasis of breast cancer identified
Researchers at the University of California, San Diego School of Medicine have identified an enzyme that controls the spread of breast cancer. The findings, reported in the current issue of PNAS, offer hope for the leading cause of breast cancer mortality worldwide. An estimated 40,000 women in America will die of breast cancer in 2014, according to the American Cancer Society.
Susan G. Komen for the Cure, National Institutes of Health, Pedal the Cause San Diego

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 2-Sep-2014
Nature Communications
'Prepped' by tumor cells, lymphatic cells encourage breast cancer cells to spread
Breast cancer cells can lay the groundwork for their own spread throughout the body by coaxing cells within lymphatic vessels to send out tumor-welcoming signals, according to a new report by Johns Hopkins scientists.
NIH/National Cancer Institute, Safeway Foundation for Breast Cancer

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 1-Sep-2014
Journal of Cell Biology
Scientists call for investigation of mysterious cloud-like collections in cells
About 50 years ago, electron microscopy revealed the presence of tiny blob-like structures that form inside cells, move around and disappear. But scientists still don't know what they do -- even though these shifting cloud-like collections of proteins are believed to be crucial to the cell, and therefore could offer a new approach to disease treatment. Now, researchers are issuing a call to investigators to focus their attention on the role of these formations.
Burroughs Wellcome Clinical Scientist Award in Translational Research, National Institutes of Health

Contact: Karen Teber
km463@georgetown.edu
Georgetown University Medical Center

Public Release: 31-Aug-2014
Nature Chemistry
A new synthetic amino acid for an emerging class of drugs
EPFL scientists have developed a new amino acid that can be used to modify the 3-D structure of therapeutic peptides. Insertion of the amino acid into bioactive peptides enhanced their binding affinity up to 40-fold. Peptides with the new amino acid could potentially become a new class of therapeutics.
National Centre of Competence in Research Chemical Biology, Swiss National Science Foundation, École Polytechnique Fédérale de Lausanne

Contact: Nik Papageorgiou
n.papageorgiou@epfl.ch
41-216-932-105
Ecole Polytechnique Fédérale de Lausanne

Public Release: 31-Aug-2014
British Journal of General Practice
Invisible blood in urine may indicate bladder cancer
Scientists at the University of Exeter Medical School found that one in 60 people over the age of 60 who had invisible blood in their urine -- identified by their GP testing their urine -- transpired to have bladder cancer. The figure was around half those who had visible blood in their urine -- the best known indicator of bladder cancer. However, it was still higher than figures for other potential symptoms of bladder cancer that warrant further investigation.

Contact: Louise Vennells
l.vennells@exeter.ac.uk
44-139-272-2062
University of Exeter

Showing releases 51-75 out of 1224.

<< < 1 | 2 | 3 | 4 | 5 | 6 | 7 > >>

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