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Showing releases 51-75 out of 1241.

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Public Release: 9-Apr-2014
JAMA Surgery
Patients over 65 have more complications after colorectal cancer surgery
Most colorectal cancer surgeries are performed on patients older than 65 years, and older patients have worse outcomes than younger patients, although the total number of colon cancer operations has decreased in the past decade.

Contact: John Murray
jdmurray@uci.edu
714-456-7759
The JAMA Network Journals

Public Release: 9-Apr-2014
Neurology
Older people with faster decline in memory/thinking skills may have lower risk of cancer death
Older people who are starting to have memory and thinking problems, but do not yet have dementia may have a lower risk of dying from cancer than people who have no memory and thinking problems, according to a study published in the April 9, 2014, online issue of Neurology, the medical journal of the American Academy of Neurology.

Contact: Rachel Seroka
rseroka@aan.com
612-928-6129
American Academy of Neurology

Public Release: 9-Apr-2014
Journal of the National Cancer Institute
Consuming a high-fat diet is associated with increased risk of certain types of BC
High total and saturated fat intake were associated with greater risk of estrogen receptor- and progesterone receptor-positive breast cancer, and human epidermal growth factor 2 receptor-negative disease, according to a new study published April 9 in the Journal of the National Cancer Institute.

Contact: Zachary Rathner
Zachary.Rathner@oup.com
919-677-2697
Oxford University Press USA

Public Release: 9-Apr-2014
Nature
A bad penny: Cancer's thirst for copper can be targeted
Drugs used to block copper absorption for a rare genetic condition may find an additional use as a treatment for certain types of cancer, researchers at Duke Medicine report.
National Institutes of Health

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

Public Release: 9-Apr-2014
Nature
Novel approach to accelerate metabolism could lead to new obesity treatment
By manipulating a biochemical process that underlies cells' energy-burning abilities, investigators at Beth Israel Deaconess Medical Center have made a novel discovery that could lead to a new therapy to combat obesity and diabetes.
National Institutes of Health, JPB Foundation, Klarman Foundation, Deutsche Forschungsgemeinschaft, American Heart Association, Ellison Medical Foundation, Academy of Finland Grant.

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center

Public Release: 8-Apr-2014
Journal of Experimental Medicine
Montreal researchers explain how our immune system kills abnormal blood cells
A team of researchers at the IRCM, led by Andre Veillette, M.D., explains how our immune system kills abnormal blood cells. Their discovery, recently published in the Journal of Experimental Medicine, could eventually lead to new treatment avenues for leukemia, lymphoma and certain types of infectious viral diseases.
Canadian Institutes of Health Research, Canadian Cancer Society Research Institute, Canada Research Chairs

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal

Public Release: 8-Apr-2014
Nature
Breast cancer cell subpopulation cooperation can spur tumor growth
Sub-populations of breast cancer cells sometimes cooperate to aid tumor growth, according to Penn State College of Medicine researchers, who believe that understanding the relationship between cancer sub-populations could lead to new targets for cancer treatment.
NIH/National Cancer Institute, Mary Kay Foundation

Contact: Matthew Solovey
msolovey@hmc.psu.edu
717-531-8606
Penn State

Public Release: 8-Apr-2014
American Association for Cancer Research (AACR) Annual Meeting 2014
Dartmouth researchers identify potential therapeutic target for deadly brain cancer
Researchers from the Geisel School of Medicine at Dartmouth will present a scientific poster on Tuesday, April 8, 2014, at the American Association of Cancer Researchers conference in San Diego, Calif. The research identifies a potential characteristic for predicting outcome in a deadly form of brain cancer known as glioblastoma multiforme.

Contact: Robin Dutcher
robin.Dutcher@hitchcock.org
603-653-9056
The Geisel School of Medicine at Dartmouth

Public Release: 8-Apr-2014
American Association for Cancer Research (AACR) Annual Meeting 2014
Study examines biomarkers in HPV negative squamous-cell carcinomas of the head and neck
A quartet of proteins that play critical roles in cell replication, cell death and DNA repair could lead to better targets for therapy against treatment-resistant head-and-neck squamous cell cancers.

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-815-7828
Fox Chase Cancer Center

Public Release: 8-Apr-2014
Health Affairs
Global health funding reaches new high as funding priorities shift
Global health funding hit an all-time high of $31.3 billion in 2013, five times greater than in 1990. Yet with 3.9 percent growth from 2012 to 2013, the year-over-year increase falls short of the rapid rates seen over the previous decade, according to new research by the Institute for Health Metrics and Evaluation at the University of Washington being published online in a web first edition on Apr. 8 by Health Affairs.

Contact: Rhonda Stewart
stewartr@uw.edu
206-897-2863
Institute for Health Metrics and Evaluation

Public Release: 8-Apr-2014
American Association for Cancer Research (AACR) Annual Meeting 2014
Phase II trial of efatutazone shows challenge of matching treatment to population
Work at the University of Colorado Cancer Center led to phase II trial of efatutazone with erlotinib in patients with refractory non-small cell lung cancer. Results are reported today at the American Association for Cancer Research Annual Meeting 2014. While efatutazone did not improve the efficacy of erlotinib in this trial, researchers hope lessons from the trial will allow them to make better future use of the drug or other drugs in its class.

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

Public Release: 8-Apr-2014
Biostatistics
New epidemiology model combines multiple genomic data
Data about DNA differences, gene expression, or methylation can each tell epidemiologists something about the link between genomics and disease. A new statistical model that can integrate all those sources provides a markedly improved analysis, according to two new papers.
National Institutes of Health, Brown University

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

Public Release: 8-Apr-2014
JAMA
Chemotherapy may be better for certain patients with advanced lung cancer
Among patients with advanced non-small cell lung cancer without a mutation of a certain gene, conventional chemotherapy, compared with treatment using epidermal growth factor receptor tyrosine kinase inhibitors, was associated with improvement in survival without progression of the cancer, but not with overall survival, according to a study in the April 9 issue of JAMA.

Contact: Dong-Wan Kim
kimdw@snu.ac.kr
The JAMA Network Journals

Public Release: 8-Apr-2014
American Association for Cancer Research (AACR) Annual Meeting 2014
Fox Chase study identifies the process in which heat shock protein 90 contributes to metastases in ovarian cancer
By incapacitating the activities of a protein that guides other proteins to fold into a stable shapes, Fox Chase Cancer Center researchers shut off the spigot for two proteases that help ovarian cancer cells chew their way out of the tissue they grow in and dig in at new locations.

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-815-7828
Fox Chase Cancer Center

Public Release: 8-Apr-2014
Lancet Oncology
Unexpected results in cancer drug trial
Research from the University of Southampton has shown a drug, used in combination with chemotherapy to treat advanced colorectal cancer, is not effective in some settings, and indeed may result in more rapid cancer progression.
Cancer Research UK

Contact: Becky Attwood
r.attwood@soton.ac.uk
44-023-805-95457
University of Southampton

Public Release: 8-Apr-2014
American Association for Cancer Research (AACR) Annual Meeting 2014
Deep, integrated genomic analysis re-classifies lower-grade brain tumors
Comprehensive genomic analysis of low-grade brain tumors sorts them into three categories, one of which has the molecular hallmarks and shortened survival of glioblastoma multiforme.
NIH/National Cancer Institute

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center

Public Release: 8-Apr-2014
Alcoholism: Clinical & Experimental Research
National survey links teen binge drinking and alcohol brand references in pop music
A study links brand mentions in popular music lyrics to binge drinking in teens and young adults. The influence of music was found to be as strong as peer and parental influence on drinking patterns.
National Institutes of Health, NIH/National Cancer Institute

Contact: Donna Dubuc
donna.M.Dubuc@Dartmouth.edu
603-653-3615
The Geisel School of Medicine at Dartmouth

Public Release: 8-Apr-2014
Journal of Clinical Investigation
JCI online ahead of print table of contents for April 8, 2014
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers published online, April 8, 2014 in the JCI: 'Visualizing calcium dynamics in the kidney,' 'Characterization of an asplenic patient with disorder of sexual development,' 'Vascular rarefaction mediates whitening of brown fat in obesity,' 'Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes,' 'CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis,' and more.

Contact: Corinne Wiliams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 8-Apr-2014
Blood
Experimental drug shows promise for treatment-resistant leukemias
Research in mice and human cell lines has identified an experimental compound dubbed TTT-3002 as potentially one of the most potent drugs available to block genetic mutations in cancer cells blamed for some forms of treatment-resistant leukemia.
NIH/National Cancer Institute

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 8-Apr-2014
Proceedings of the National Academy of Sciences
Scientists reveal potential link between brain development and breast cancer gene
Scientists at the Salk Institute have uncovered details into a surprising -- and crucial -- link between brain development and a gene whose mutation is tied to breast and ovarian cancer. Aside from better understanding neurological damage associated in a small percentage of people susceptible to breast cancers, the new work also helps to better understand the evolution of the brain.

Contact: Chris Emery
Cemery@salk.edu
301-873-6952
Salk Institute

Public Release: 8-Apr-2014
Few Americans know where elected officials and candidates stand on government support for research
Two-thirds of Americans (66 percent) say it's important for candidates running for office to assign a high priority to funding medical research, according to America Speaks, Volume 14, a compilation of key questions from public opinion polls commissioned by Research!America. Polling shows that Americans place a high value on US leadership in medical innovation, yet only 12 percent say they are very well informed about the positions of their senators and representative when it comes to their support of medical and scientific research.

Contact: Anna Briseno
abriseno@researchamerica.org
571-482-2737
Research!America

Public Release: 8-Apr-2014
Applied and Environmental Microbiology
Western University study unlocking secrets of breast tissue
A unique population of microbes in the female breast may lay the groundwork for understanding how this bacterial community contributes to health and disease, according to a new study out of Western University. Forms of bacteria known as 'Proteobacteria' were the most abundant, potentially as they are able to metabolize the fatty tissue, said the paper's first author, Camilla Urbaniak, a Ph.D. student.

Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario

Public Release: 8-Apr-2014
Nature Communications
Blocking DNA repair mechanisms could improve radiation therapy for deadly brain cancer
UT Southwestern Medical Center researchers have demonstrated in both cancer cell lines and in mice that blocking critical DNA repair mechanisms could improve the effectiveness of radiation therapy for highly fatal brain tumors called glioblastomas.
National Institutes of Health, NASA, Cancer Prevention and Research Institute of Texas

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 8-Apr-2014
eLife
Kinesin-5 structure opens cancer drug targets
The structure of a key part of the machinery that allows cells to divide has been identified by researchers at UC Davis -- opening new possibilities for throwing a wrench in the machine and blocking runaway cell division in cancer.
National Institutes of Health

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis

Public Release: 7-Apr-2014
American Association for Cancer Research (AACR) Annual Meeting 2014
New breast cancer results illustrate promise and potential of I-SPY 2 trial
In an innovative clinical trial led by UC San Francisco, the experimental drug neratinib along with standard chemotherapy was found to be a beneficial treatment for some women with newly diagnosed, high-risk breast cancer.

Contact: Elizabeth Fernandez
elizabeth.fernandez@ucsf.edu
415-502-6397
University of California - San Francisco

Showing releases 51-75 out of 1241.

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