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Public Release: 7-Aug-2014
Cell
Cancer study reveals powerful new system for classifying tumors
Cancers are classified primarily on the basis of where in the body the disease originates, as in lung cancer or breast cancer. According to a new study, however, one in 10 cancer patients would be classified differently using a new classification system based on molecular subtypes instead of the current tissue-of-origin system. This reclassification could lead to different therapeutic options for those patients.
National Institutes of Health

Contact: Tim Stephens
stephens@ucsc.edu
831-459-2495
University of California - Santa Cruz

Public Release: 7-Aug-2014
Cancer Prevention Research
Gut microbiome analysis improved noninvasive colorectal cancer screening
Analysis of the gut microbiome more successfully distinguished healthy individuals from those with precancerous adenomatous polyps and those with invasive colorectal cancer compared with assessment of clinical risk factors and fecal occult blood testing, according to data published in Cancer Prevention Research, a journal of the American Association for Cancer Research.
National Institutes of Health

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 7-Aug-2014
Cell
Largest cancer genomic study proposes 'disruptive' new system to reclassify tumors
After analyzing more than 3,500 tumors on multiple technology platforms TCGA researchers say cancers are more likely to be similar based on their cell type of origin as opposed to their tissue type of origin. The study suggests at least 10 percent of cancer patients would be classified differently under this protocol. But Buck faculty Christopher Benz thinks this fraction will swell when more samples and additional tumor types are included in the next analysis.
NIH/National Cancer Institute, NIH/National Human Genome Research Institute

Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2080
Buck Institute for Age Research

Public Release: 6-Aug-2014
New England Journal of Medicine
Gene increases risk of breast cancer to 1 in 3 by age 70
Breast cancer risks for one of potentially the most important genes associated with breast cancer after the BRCA1/2 genes are today reported in the New England Journal of Medicine. Women with mutations in the PALB2 gene have on average a one in three chance of developing breast cancer by the age of 70.
European Research Council, Cancer Research UK

Contact: Craig Brierley
craig.brierley@admin.cam.ac.uk
44-012-237-66205
University of Cambridge

Public Release: 6-Aug-2014
Cancer Epidemiology, Biomarkers & Prevention
Nearly 10 percent of patients with cancer still smoke
Nine years after diagnosis, 9.3 percent of US cancer survivors were current smokers and 83 percent of these individuals were daily smokers who averaged 14.7 cigarettes per day, according to a report in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 6-Aug-2014
Cancer Epidemiology, Biomarkers & Prevention
Study: Many cancer survivors smoke years after diagnosis
Nearly one in 10 cancer survivors reports smoking many years after a diagnosis, according to a new study.
American Cancer Society

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society

Public Release: 6-Aug-2014
Clinical Gastroenterology and Hepatology
Exposure to inflammatory bowel disease drugs could increase leukemia risk
Immunosuppressive drugs called thiopurines have been found to increase the risk of myeloid disorders, such as acute myeloid leukemia and myelodysplastic syndrome, a rare bone marrow disorder, seven-fold among inflammatory bowel disease patients.

Contact: Rachel Steigerwald
media@gastro.org
301-272-1603
American Gastroenterological Association

Public Release: 6-Aug-2014
Cell Transplantation
Researchers seek 'safety lock' against tumor growth after stem cell transplantation
Induced pluripotent stem cell-derived neural stem cells can promote functional recovery after spinal cord injury to laboratory animals; a drawback is their potential for tumorogenesis post-transplantation. To better understand this, researchers transplanted a human glioblastoma cell line into the intact spinal columns of laboratory mice that were either immunodeficient or immunocompetent, and treated with or without immunosuppressant drugs. They found that withdrawing immunosuppressant drugs eliminated tumor growth and created a 'safety lock' against tumor formation.
Japan Science and Technology, California Institute for Regenerative Medicine, Research Center Network for Realization of Regenerative Medicine, Centers for Clinical Application Research on Specific Disease/Organ

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair

Public Release: 6-Aug-2014
Cancer Research
Brain tumors fly under the body's radar like stealth jets, new U-M research suggests
Brain tumors fly under the radar of the body's defense forces by coating their cells with extra amounts of a specific protein, new research shows. Like a stealth fighter jet, the coating means the cells evade detection by the early-warning immune system that should detect and kill them. The stealth approach lets the tumors hide until it's too late for the body to defeat them.
NIH/National Institute of Neurological Disorders & Stroke

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 6-Aug-2014
Proceedings of the National Academy of Sciences
Discovery yields master regulator of toxin production in staph infections
St. Jude Children's Research Hospital scientists have discovered an enzyme that regulates production of the toxins that contribute to potentially life-threatening Staphylococcus aureus infections. The study recently appeared in the scientific journal the Proceedings of the National Academy of Sciences. Researchers also showed that the same enzyme allows Staphylococcus aureus to use fatty acids acquired from the infected individual to make the membrane that bacteria need to grow and flourish.
National Institutes of Health, NIH/National Cancer Institute, American Lebanese Syrian Associated Charities

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Public Release: 6-Aug-2014
Nature
A new way to model cancer
New gene-editing technique from researchers at MIT allows scientists to more rapidly study the role of mutations in tumor development.
National Institutes of Health, NIH/National Cancer Institute

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology

Public Release: 6-Aug-2014
Optics Letters
New hand-held device uses lasers, sound waves for deeper melanoma imaging
Melanoma is the deadliest form of skin cancer, causing more than 75 percent of skin-cancer deaths. The thicker the melanoma tumor, the more likely it will spread and the deadlier it becomes. Now, a team of researchers from Washington University in St. Louis have developed a new hand-held device that uses lasers and sound waves that may change the way doctors treat and diagnose melanoma. The tool is ready for commercialization and clinical trials.

Contact: Lyndsay Meyer
lmeyer@osa.org
202-416-1435
The Optical Society

Public Release: 5-Aug-2014
Review of Scientific Instruments
3-in-1 optical skin cancer probe
Researchers from the University of Texas at Austin's Cockrell School of Engineering have now developed a probe that combines into one device three unique ways of using light to measure the properties of skin tissue and detect cancer. The researchers have begun testing their 3-in-1 device in pilot clinical trials and are partnering with funding agencies and start-up companies to help bring the device to dermatologists' offices.

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
American Institute of Physics

Public Release: 5-Aug-2014
Canadian Medical Association Journal
No apparent link between sleep apnea and cancer: Large study
There appears to be no link between obstructive sleep apnea and cancer development, according to a large study published in CMAJ. Several previous studies have shown an association, although they have been small and contain measurement biases.

Contact: Deborah Creatura
Deborah.Creatura@ices.on.ca
416-480-4780
Canadian Medical Association Journal

Public Release: 5-Aug-2014
Radiology
Mammography benefits women over 75
Mammography-detected breast cancer is associated with a shift to earlier stage diagnosis in older women, subsequently reducing the rate of more advanced, difficult-to-treat cases, according to a new study. Researchers said the findings lend support to regular mammography screening in women ages 75 and older.
Kaplan Cancer Research Fund

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America

Public Release: 5-Aug-2014
Annals of Oncology
Aspirin: Scientists believe cancer prevention benefits outweigh harms
New research from Queen Mary University of London reveals taking aspirin can significantly reduce the risk of developing -- and dying from -- the major cancers of the digestive tract, i.e. bowel, stomach and esophageal cancer.

Contact: Charli Scouller
c.scouller@qmul.ac.uk
020-788-27943
Queen Mary, University of London

Public Release: 5-Aug-2014
Nucleic Acids Research
'Treatments waiting to be discovered' inside new database
A University of Colorado Cancer Center study recently published in the top-ranked journal Nucleic Acids Research describes a database named multiMiR, the most comprehensive database collecting information about microRNAs and their targets.
National Institutes of Health, NIH/National Cancer Institute

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

Public Release: 5-Aug-2014
Gastroenterology
Genetic testing of tumor is recommended for colorectal cancer patients
Of the 143,000 patients diagnosed with colorectal cancer annually in the US, up to 25 percent have a familial risk of colorectal cancer. A new guideline from the US Multi-Society Task Force on Colorectal Cancer recommends genetic testing of tumors for all newly diagnosed colorectal cancer patients.

Contact: Aimee Frank
media@gastro.org
301-941-2620
American Gastroenterological Association

Public Release: 5-Aug-2014
American Journal of Respiratory and Critical Care Medicine
Cancer fighter can help battle pneumonia
The tip of an immune molecule known for its skill at fighting cancer may also help patients survive pneumonia, scientists report.
National Institutes of Health

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University

Public Release: 5-Aug-2014
Electronic cigarettes: Many questions, limited research
Electronic cigarettes are booming in popularity -- but there's still only limited evidence on their potential health risks, or their advertised benefits in helping people to quit smoking, according to a research review in the July/August Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health

Public Release: 4-Aug-2014
Journal of Clinical Oncology
Patient navigation may aid in breast cancer treatment in high-risk populations
Patient navigation, or the linking of a newly diagnosed cancer patient with a professional trained in assisting patients though the complex journey of cancer diagnosis and treatment, may lead to better breast cancer care in high risk and minority women.

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center

Public Release: 4-Aug-2014
BMC Cell Biology
Cell plasticity may provide clues to origin of aggressive type of breast cancer
Healthy breast cells may be able to reinvent themselves -- some have the flexibility to change after they are mature -- which leads researchers to postulate that similarities exist between this occurrence and the origins of a particularly aggressive type of breast cancer.
Susan G. Komen for the Cure, The Breast Cancer Research Foundation, Oracle Giving, Indiana University Melvin and Bren Simon Cancer Center, Indiana University Department of Surgery

Contact: Mary Hardin
mhardin@iu.edu
317-274-5456
Indiana University

Public Release: 4-Aug-2014
PLOS ONE
Triple therapy revs up immune system against common brain tumor
A triple therapy for glioblastoma, including two types of immunotherapy and targeted radiation, has significantly prolonged the survival of mice with these brain cancers, according to a new report by scientists at the Johns Hopkins Kimmel Cancer Center.
WW Smith Charitable Foundation

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 4-Aug-2014
International Journal of Radiation Oncology Biology Physics
Single-fraction RT as effective as multiple-fraction RT for palliation of bone metastases
Standardizing prescribing practices for single-fraction radiation therapy for palliation of bone metastases could lead to cost savings and improvement in patients' quality of life, according to a study published in the Aug. 1, 2014, edition of the International Journal of Radiation Oncology ● Biology ● Physics, the official scientific journal of the American Society for Radiation Oncology.

Contact: Michelle Kirkwood
press@astro.org
703-286-1600
American Society for Radiation Oncology

Public Release: 4-Aug-2014
JAMA
Version 2.0 of Prostate Cancer Risk Calculator now online, complete with emojis
A calculator to help men and their doctors assess their risk of prostate cancer has had a major upgrade, described online Monday in the Journal of the American Medical Association. 'The current version gives a more nuanced result that helps understand a man's risk of prostate cancer,' said Ian M. Thompson Jr., M.D., director of the Cancer Therapy & Research Center at the UT Health Science Center, who helped develop the risk calculator.
NIH/National Cancer Institute

Contact: Elizabeth Allen
210-450-2020
University of Texas Health Science Center at San Antonio

Showing releases 76-100 out of 1258.

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