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Showing releases 76-100 out of 1272.

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Public Release: 13-Nov-2014
Science
Direct drug screening of patient biopsies could overcome resistance to targeted therapy
A new screening platform using cells grown directly from tumor biopsy samples may lead to truly individualized treatment strategies that would get around the problem of treatment resistance, which limits the effectiveness of current targeted therapy drugs.
National Institutes of Health, Wellcome Trust, Department of Defense, Conquer CNational Institutes of Health, Wellcome Trust, US Department of Defense, Coancer Foundation, Uniting Against Lung Cancer, Free to Breathe, Lungevity, Be a Piece of the Solution

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital

Public Release: 13-Nov-2014
Cancer Immunology, Immunotherapy
Novel cancer vaccine approach for brain tumors
Researchers unravel the mechanisms behind a novel cancer vaccine for brain tumors, paving the way for further development.

Contact: Edyta Zielinska
edyta.zielinska@jefferson.edu
215-955-5291
Thomas Jefferson University

Public Release: 13-Nov-2014
Cell Stem Cell
Tumor suppressor also inhibits key property of stem cells, Stanford researchers say
A protein that plays a critical role in preventing the development of many types of human cancers has been shown also to inhibit a vital stem cell property called pluripotency, according to a study by researchers at the Stanford University School of Medicine.
NIH/National Cancer Institute, Spectrum Child Health, Lucile Packard Foundation for Children's Health, California Institute for Regenerative Medicine New York Stem Cell Foundation

Contact: Krista Conger
kristac@stanford.edu
650-725-5371
Stanford University Medical Center

Public Release: 13-Nov-2014
Journal of National Cancer Institute
Genetic testing could improve breast cancer prevention
Screening women for a wide range of known genetic risk factors could improve strategies for breast cancer prevention, a new analysis shows.

Contact: Amy Drummond
amy.drummond@icr.ac.uk
020-715-35380
Institute of Cancer Research

Public Release: 13-Nov-2014
Cell
Hedgehog signaling pathway for breast cancer identified
Molecules called long non-coding RNAs -- lncRNAs -- have been implicated in breast cancer but exactly why they cause metastasis and tumor growth has been little understood... until now.

Contact: Ron Gilmore
rlgilmore1@mdanderson.org
713-745-1898
University of Texas M. D. Anderson Cancer Center

Public Release: 13-Nov-2014
Clinical Cancer Research
Cancer-killing virus plus chemotherapy drug might treat recurrent ovarian cancer
In six out of 10 cases, ovarian cancer is diagnosed when the disease is advanced and five-year survival is only 27 percent. A new study suggests that a cancer-killing virus combined with a chemotherapy drug might safely and effectively treat advanced or recurrent forms of the disease.
NIH/National Cancer Institute

Contact: Darrell E. Ward
darrell.ward@osumc.edu
614-293-3737
Ohio State University Wexner Medical Center

Public Release: 13-Nov-2014
EMBO Molecular Medicine
Scientists develop scoring scheme that predicts ability of cancer cells to spread
Scientists at the Cancer Science Institute of Singapore at the National University of Singapore and their collaborators have developed a scoring scheme that predicts the ability of cancer cells to spread to other parts of the body, a process known as metastasis. This system, which is the first of its kind, opens up the possibility to explore new treatments that suppress metastasis in cancer patients.

Contact: Kimberley Wang
kimberley.wang@nus.edu.sg
National University of Singapore

Public Release: 13-Nov-2014
Cancer Cell
How the breast cancer cells transform normal cells into tumoral ones?
Researchers at the Bellvitge Biomedical Research Institute of Bellvitge, the Catalan Institute of Oncology and the University Hospital of Bellvitge have participated in an international study published in the journal Cancer Cell that describes how exosomes secreted by tumor cells contain protein and microRNA molecules capable of transform neighboring cells into tumoral cells promoting tumor growth.

Contact: Arantxa Mena
amena@idibell.cat
34-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 13-Nov-2014
BMJ Open
Britain's obese in denial about their weight
A majority of obese people in Britain would not describe themselves as 'obese,' and many would not even describe themselves as 'very overweight,' according to a Cancer Research UK study published in BMJ Open Friday.
Cancer Research UK

Contact: Stephanie McClellan
stephanie.mcclellan@cancer.org.uk
44-020-346-95314
Cancer Research UK

Public Release: 12-Nov-2014
Environmental Science & Technology
A previously unrecognized flame retardant found in Americans for the first time
This is the first study to find the carcinogenic flame retardant TCEP in the bodies of Americans. It's also the first study to evaluate urinary levels of several phosphate flame retardant metabolites, like TCEP, which have been largely under the radar. Six metabolites were found in urine samples from California residents. People with the highest metabolite levels of two carcinogenic flame retardants also had the highest levels in their house dust, which were previously tested.
NIH/National Institute of Environmental Health Sciences, New York Community Trust, Fine Fund, Art beCAUSE Breast Cancer Foundation

Contact: Amelia Jarvinen
jarvinen@silentspring.org
617-332-4288 x226
Silent Spring Institute

Public Release: 12-Nov-2014
JAMA Surgery
Quarter of patients have subsequent surgery after breast conservation surgery
Nearly one-quarter of all patients who underwent initial breast conservation surgery for breast cancer had a subsequent surgical intervention, according to a report published online by JAMA Surgery.

Contact: Susan L. Smith
SSmith5@uwhealth.org
608-890-5643
The JAMA Network Journals

Public Release: 12-Nov-2014
Cancer Epidemiology, Biomarkers & Prevention
Oral cancer-causing HPV may spread through oral and genital routes
Oral human papillomavirus (HPV) infections were more common among men who had female partners with oral and/or genital HPV infection, suggesting that the transmission of HPV occurs via oral-oral and oral-genital routes, according to a McGill University study led by professsor Eduardo L. Franco.
Canadian Institutes for Health Research, National Institutes of Health

Contact: Cynthia Lee
cynthia.lee@mcgill.ca
514-398-6754
McGill University

Public Release: 12-Nov-2014
Cancer Research
Innovative approach to treating pancreatic cancer combines chemo- and immuno-therapy
VCU Massey Cancer Center and VCU Institute of Molecular Medicine researchers discovered a unique approach to treating pancreatic cancer that may be potentially safe and effective.
NIH/National Cancer Institute

Contact: John Wallace
wallacej@vcu.edu
804-628-1550
Virginia Commonwealth University

Public Release: 12-Nov-2014
Cancer Discovery
Gene sequencing projects link two mutations to Ewing sarcoma subtype with poor prognosis
An international collaboration has identified frequent mutations in two genes that often occur together in Ewing sarcoma and that define a subtype of the cancer associated with reduced survival. The research, conducted by the St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project and the Institut Curie-Inserm through the International Cancer Genome Consortium, appears in the current issue of the scientific journal Cancer Discovery.
Pediatric Cancer Genome Project, Kay Jewelers, NIH/National Cancer Institute, National Institutes of Health, French National Cancer Institute, Inserm, National Research Agency for Science Projects, Canceropole Ile-de-France, French League Against Cancer

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Public Release: 12-Nov-2014
Lancet Oncology
Prostate cancer researchers develop personalized genetic test to predict recurrence risk
Prostate cancer researchers have developed a genetic test to identify which men are at highest risk for their prostate cancer to come back after localized treatment with surgery or radiotherapy.
Prostate Cancer Canada, The Movember Foundation, Ontario Institute for Cancer Research, The Princess Margaret Cancer Foundation, Wellcome Trust Clinical Research Facility

Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network

Public Release: 11-Nov-2014
Journal of Nuclear Medicine
Novel molecular imaging drug offers better detection of prostate cancer
A novel study demonstrates the potential of a novel molecular imaging drug to detect and visualize early prostate cancer in soft tissue, lymph nodes and bone. The research, published in the November issue of the Journal of Nuclear Medicine, compares the biodistribution and tumor uptake kinetics of two Tc-99m labeled ligands, MIP-1404 and MIP-1405, used with SPECT and planar imaging.

Contact: Kimberly Brown
kbrown@snmmi.org
703-652-6773
Society of Nuclear Medicine

Public Release: 11-Nov-2014
RSNA 2014
Tumor-analysis technology enables speedier treatment decisions for bowel-cancer patients
Technology developed at the University of Sussex helps hospitals make earlier and more accurate treatment decisions and survival assessments for patients with bowel cancer.

Contact: James Hakner
press@sussex.ac.uk
44-127-367-8888
University of Sussex

Public Release: 11-Nov-2014
Journal of Biological Chemistry
Penn Vet team pieces together signaling pathway leading to obesity
A team of researchers led by the University of Pennsylvania School of Veterinary Medicine's Kendra K. Bence have now drawn connections between known regulators of body mass, pointing to possible treatments for obesity and metabolic disorders.
National Institutes of Health, Penn's Institute for Diabetes, Obesity and Metabolism

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania

Public Release: 11-Nov-2014
Molecular Cancer Therapeutics
Next-gen melanoma drug, TAK-733, excels in lab tests
A University of Colorado Cancer Center study published online this week in the journal Molecular Cancer Therapeutics reports anti-cancer activity in 10 out of 11 patient tumor samples grown in mice and treated with the experimental drug TAK-733, a small molecule inhibitor of MEK1/2.

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

Public Release: 10-Nov-2014
JAMA Internal Medicine
ACP releases High Value Care advice for communicating about end-of-life care goals
Physician-patient communication about goals of care is a low risk, high value intervention for patients with a life threatening illness, the American College of Physicians advises in a paper published in JAMA Internal Medicine.

Contact: Steve Majewski
smajewski@acponline.org
American College of Physicians

Public Release: 10-Nov-2014
Blood
Researchers discover new target for blood cancer treatment
Scientists at the University of York have identified a therapeutic target which could lead to the development of new treatments for specific blood cancers.

Contact: David Garner
david.garner@york.ac.uk
44-019-043-22153
University of York

Public Release: 10-Nov-2014
Journal of Women's Health
New approach helps women talk to their families about cancer risk
To understand their risk for hereditary forms of cancer, such as breast and colon cancer, women need to know their family history. The design and effectiveness of a 20-minute skills-based intervention that can help women better communicate with relatives and gather and share information about cancer family history is described in a study in Journal of Women's Health.

Contact: Kathryn Ryan
kryan@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 10-Nov-2014
New England Journal of Medicine
Lung cancer screening with low-dose CT could be cost effective says Dartmouth study
Dartmouth researchers say lung cancer screening in the National Lung Screening Trial meets a commonly accepted standard for cost effectiveness as reported in the Nov. 6 issue of the New England Journal of Medicine. This relatively new screening test uses annual low-dose CT scans to spot lung tumors early in individuals facing the highest risks of lung cancer due to age and smoking history.
NIH/National Cancer Institute

Contact: Rick Adams
Clarence.R.Adams@hitchcock.org
603-653-1910
The Geisel School of Medicine at Dartmouth

Public Release: 10-Nov-2014
Journal of Clinical Oncology
Smoking associated with elevated risk of developing a second smoking-related cancer
Results of a federally-funded pooled analysis of five prospective cohort studies indicate that cigarette smoking prior to the first diagnosis of lung (stage I), bladder, kidney or head and neck cancer increases risk of developing a second smoking-associated cancer. This is the largest study to date exploring risk of second cancers among current smokers.
NIH/National Cancer Institute

Contact: Kate Blackburn
kate.blackburn@asco.org
571-483-1379
American Society of Clinical Oncology

Public Release: 10-Nov-2014
Journal of Thoracic Oncology
Interstitial lung disease is a significant risk factor for lung inflammation
Pretreatment interstitial lung disease is a significant risk factor for developing symptomatic and severe radiation pneumonitis in stage I non-small cell lung cancer patients treated with stereotactic body radiation therapy alone.

Contact: Murry W. Wynes
murry.wynes@iaslc.org
720-325-2945
International Association for the Study of Lung Cancer

Showing releases 76-100 out of 1272.

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