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Showing releases 76-100 out of 1230.

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Public Release: 10-Apr-2014
International Liver Congress 2014
New prediction model to improve patient survival after paracetamol-related liver failure
A new prediction model is to improve patient survival after paracetamol-related liver failure.

Contact: Courtney Lock
European Association for the Study of the Liver

Public Release: 10-Apr-2014
Cell Metabolism
Lactate metabolism target halts growth in lung cancer model
A team led by investigators at Beth Israel Deaconess Medical Center has found that an enzyme responsible for the final step of glucose metabolism not only halts tumor growth in non-small-cell lung cancer, but actually leads to regression of established tumors.
National Institutes of Health, US Department of Defense

Contact: Bonnie Prescott
Beth Israel Deaconess Medical Center

Public Release: 10-Apr-2014
American Association for Cancer Research (AACR) Annual Meeting 2014
AACR 2014 study highlights new drug, molecular insight into triple negative breast cancers
University of Colorado Cancer Center study presented today at the American Association for Cancer Research Annual Meeting 2014 showcased a new drug active against triple-negative breast cancer, and through analysis of the drug's mechanism of action, offers increased understanding of the biology of this very aggressive form of breast cancer.

Contact: Garth Sundem
University of Colorado Denver

Public Release: 10-Apr-2014
3-D printing cancer cells to mimic tumors
A group of researchers in China and the US have successfully created a 3-D model of a cancerous tumor using a 3-D printer.

Contact: Michael Bishop
Institute of Physics

Public Release: 10-Apr-2014
Researchers identify transcription factors distinguishing glioblastoma stem cells
The activity of four transcription factors -- proteins that regulate the expression of other genes -- appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor.
Howard Hughes Medical Institute, Starr Cancer Consortium, Burroughs Wellcome Fund, Oncosuisse, Klarman Family Foundation

Contact: Sue McGreevey
Massachusetts General Hospital

Public Release: 9-Apr-2014
A bad penny: Cancer's thirst for copper can be targeted
Drugs used to block copper absorption for a rare genetic condition may find an additional use as a treatment for certain types of cancer, researchers at Duke Medicine report.
National Institutes of Health

Contact: Sarah Avery
Duke University Medical Center

Public Release: 9-Apr-2014
Novel approach to accelerate metabolism could lead to new obesity treatment
By manipulating a biochemical process that underlies cells' energy-burning abilities, investigators at Beth Israel Deaconess Medical Center have made a novel discovery that could lead to a new therapy to combat obesity and diabetes.
National Institutes of Health, JPB Foundation, Klarman Foundation, Deutsche Forschungsgemeinschaft, American Heart Association, Ellison Medical Foundation, Academy of Finland Grant.

Contact: Bonnie Prescott
Beth Israel Deaconess Medical Center

Public Release: 9-Apr-2014
Journal of the National Cancer Institute
Consuming a high-fat diet is associated with increased risk of certain types of BC
High total and saturated fat intake were associated with greater risk of estrogen receptor- and progesterone receptor-positive breast cancer, and human epidermal growth factor 2 receptor-negative disease, according to a new study published April 9 in the Journal of the National Cancer Institute.

Contact: Zachary Rathner
Oxford University Press USA

Public Release: 9-Apr-2014
JAMA Surgery
Patients over 65 have more complications after colorectal cancer surgery
Most colorectal cancer surgeries are performed on patients older than 65 years, and older patients have worse outcomes than younger patients, although the total number of colon cancer operations has decreased in the past decade.

Contact: John Murray
The JAMA Network Journals

Public Release: 9-Apr-2014
Older people with faster decline in memory/thinking skills may have lower risk of cancer death
Older people who are starting to have memory and thinking problems, but do not yet have dementia may have a lower risk of dying from cancer than people who have no memory and thinking problems, according to a study published in the April 9, 2014, online issue of Neurology, the medical journal of the American Academy of Neurology.

Contact: Rachel Seroka
American Academy of Neurology

Public Release: 9-Apr-2014
International Liver Congress 2014
EASL publishes online recommendations on the management of hepatitis C
The European Association for the Study of the Liver will this week be announcing new online recommendations on the management of hepatitis C at the International Liver Congress.

Contact: Courtney Lock
European Association for the Study of the Liver

Public Release: 9-Apr-2014
Clinical & Experimental Metastasis
TGen identifies growth factor receptors that may prompt metastatic spread of lung cancer
Two cell surface receptors might be responsible for the most common form of lung cancer spreading to other parts of the body, according to a study by the Translational Genomics Research Institute. The hepatocyte growth factor receptor and fibroblast growth factor-inducible 14 are proteins associated with the potential spread of non-small cell lung cancer, according to the TGen study published online April 8 by the scientific journal Clinical & Experimental Metastasis.
National Institutes of Health, St. Joseph's Foundation, American Lung Association

Contact: Steve Yozwiak
The Translational Genomics Research Institute

Public Release: 9-Apr-2014
Nature Cell Biology
UNC researchers show how cancer cells may respond to mechanical force
Two UNC-Chapel Hill studies, published in Nature Cell Biology and the Journal of Immunology, identify the processes and cellular pathways that allow cells to move, stiffen, and react to physical stresses. This knowledge, researchers hope, could reveal the causes of cancer and help develop treatments, including therapies for a variety of diseases.
National Institutes of Health

Contact: William Davis
University of North Carolina Health Care

Public Release: 9-Apr-2014
Journal of Clinical Investigation
Identified a new possible target to combat muscle wasting
The pathological atrophy of skeletal muscle is a serious biomedical problem for which no effective treatment is currently available. Those most affected populations are the elderly diagnosed with sarcopenia and patients with cancer, AIDS, and other infectious diseases that develop cachexia. A study by scientists at the Institute for Research in Biomedicine, headed by Antonio Zorzano, also full professor of the University of Barcelona, reveals a potential therapeutic target to tackle muscle wasting in these risk populations.
CIBERDEM, Ministry of Economy and Knowledge in Spain, EU/SUDOE programme

Contact: Sònia Armengou
Institute for Research in Biomedicine (IRB Barcelona)

Public Release: 8-Apr-2014
Lancet Oncology
Unexpected results in cancer drug trial
Research from the University of Southampton has shown a drug, used in combination with chemotherapy to treat advanced colorectal cancer, is not effective in some settings, and indeed may result in more rapid cancer progression.
Cancer Research UK

Contact: Becky Attwood
University of Southampton

Public Release: 8-Apr-2014
Few Americans know where elected officials and candidates stand on government support for research
Two-thirds of Americans (66 percent) say it's important for candidates running for office to assign a high priority to funding medical research, according to America Speaks, Volume 14, a compilation of key questions from public opinion polls commissioned by Research!America. Polling shows that Americans place a high value on US leadership in medical innovation, yet only 12 percent say they are very well informed about the positions of their senators and representative when it comes to their support of medical and scientific research.

Contact: Anna Briseno

Public Release: 8-Apr-2014
New epidemiology model combines multiple genomic data
Data about DNA differences, gene expression, or methylation can each tell epidemiologists something about the link between genomics and disease. A new statistical model that can integrate all those sources provides a markedly improved analysis, according to two new papers.
National Institutes of Health, Brown University

Contact: David Orenstein
Brown University

Public Release: 8-Apr-2014
Nature Communications
Blocking DNA repair mechanisms could improve radiation therapy for deadly brain cancer
UT Southwestern Medical Center researchers have demonstrated in both cancer cell lines and in mice that blocking critical DNA repair mechanisms could improve the effectiveness of radiation therapy for highly fatal brain tumors called glioblastomas.
National Institutes of Health, NASA, Cancer Prevention and Research Institute of Texas

Contact: Russell Rian
UT Southwestern Medical Center

Public Release: 8-Apr-2014
Applied and Environmental Microbiology
Western University study unlocking secrets of breast tissue
A unique population of microbes in the female breast may lay the groundwork for understanding how this bacterial community contributes to health and disease, according to a new study out of Western University. Forms of bacteria known as 'Proteobacteria' were the most abundant, potentially as they are able to metabolize the fatty tissue, said the paper's first author, Camilla Urbaniak, a Ph.D. student.

Contact: Kathy Wallis
519-661-2111 x81136
University of Western Ontario

Public Release: 8-Apr-2014
Experimental drug shows promise for treatment-resistant leukemias
Research in mice and human cell lines has identified an experimental compound dubbed TTT-3002 as potentially one of the most potent drugs available to block genetic mutations in cancer cells blamed for some forms of treatment-resistant leukemia.
NIH/National Cancer Institute

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 8-Apr-2014
Journal of Clinical Investigation
JCI online ahead of print table of contents for April 8, 2014
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers published online, April 8, 2014 in the JCI: 'Visualizing calcium dynamics in the kidney,' 'Characterization of an asplenic patient with disorder of sexual development,' 'Vascular rarefaction mediates whitening of brown fat in obesity,' 'Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes,' 'CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis,' and more.

Contact: Corinne Wiliams
Journal of Clinical Investigation

Public Release: 8-Apr-2014
Alcoholism: Clinical & Experimental Research
National survey links teen binge drinking and alcohol brand references in pop music
A study links brand mentions in popular music lyrics to binge drinking in teens and young adults. The influence of music was found to be as strong as peer and parental influence on drinking patterns.
National Institutes of Health, NIH/National Cancer Institute

Contact: Donna Dubuc
The Geisel School of Medicine at Dartmouth

Public Release: 8-Apr-2014
American Association for Cancer Research (AACR) Annual Meeting 2014
Deep, integrated genomic analysis re-classifies lower-grade brain tumors
Comprehensive genomic analysis of low-grade brain tumors sorts them into three categories, one of which has the molecular hallmarks and shortened survival of glioblastoma multiforme.
NIH/National Cancer Institute

Contact: Scott Merville
University of Texas M. D. Anderson Cancer Center

Public Release: 8-Apr-2014
Proceedings of the National Academy of Sciences
Scientists reveal potential link between brain development and breast cancer gene
Scientists at the Salk Institute have uncovered details into a surprising -- and crucial -- link between brain development and a gene whose mutation is tied to breast and ovarian cancer. Aside from better understanding neurological damage associated in a small percentage of people susceptible to breast cancers, the new work also helps to better understand the evolution of the brain.

Contact: Chris Emery
Salk Institute

Public Release: 8-Apr-2014
Kinesin-5 structure opens cancer drug targets
The structure of a key part of the machinery that allows cells to divide has been identified by researchers at UC Davis -- opening new possibilities for throwing a wrench in the machine and blocking runaway cell division in cancer.
National Institutes of Health

Contact: Andy Fell
University of California - Davis

Showing releases 76-100 out of 1230.

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