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Showing releases 76-100 out of 1244.

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Public Release: 17-Aug-2014
Nature Materials
Microchip reveals how tumor cells transition to invasion
A microscopic obstacle course of carefully spaced pillars enables researchers to observe cancer cells directly as they break away from a tumor mass and move more rapidly across the microchip. The device could be useful for testing cancer drugs and further research on the mechanics of metastasis. A paper describing research using the device is published in Nature Materials.
Damon Runyon Cancer Research Foundation, Howard Hughes Medical Institute, National Institutes of Health

Contact: Kevin Stacey
kevin_stacey@brown.edu
401-863-3766
Brown University

Public Release: 15-Aug-2014
American Journal of Respiratory and Critical Care Medicine
Previous pulmonary disease linked to increased lung cancer risk in large study
Links between a number of common respiratory diseases and an increased risk of developing lung cancer have been found in a large pooled analysis of seven studies involving more than 25,000 individuals.

Contact: Nathaniel Dunford
ndunford@thoracic.org
American Thoracic Society

Public Release: 15-Aug-2014
Cancer Research
New ways to treat solid tumors
An international team of scientists has shown that an antibody against the protein EphA3, found in the micro-environment of solid cancers, has anti-tumor effects.

Contact: Rachael Fergusson
rachael.fergusson@monash.edu
61-399-034-841
Monash University

Public Release: 15-Aug-2014
Lancet Oncology
Guidelines can predict early menopause in child cancer survivors
Girls with cancer who are most likely to become infertile after treatment can be identified using guidelines developed almost 20 years ago, new research from the University of Edinburgh shows.
Medical Research Council

Contact: Jen Middleton
jen.middleton@ed.ac.uk
44-131-650-6514
University of Edinburgh

Public Release: 14-Aug-2014
Cancer Research
NSAIDs benefit overweight breast cancer patients, study finds
Researchers have determined that postmenopausal overweight or obese breast cancer patients receiving hormone therapy as part of their treatment and who use nonsteroidal anti-inflammatory drugs such as aspirin or ibuprofen have significantly lower breast cancer recurrence rates and a sizable delay in time to cancer recurrence.
United States Department of Defense Breast Cancer Research Program, NIH/National Cancer Institute

Contact: Kimberly Atkins
kimberly.atkins@austin.utexas.edu
512-471-3151
University of Texas at Austin

Public Release: 14-Aug-2014
Cell
Researchers identify a mechanism that stops progression of abnormal cells into cancer
Researchers from Boston University School of Medicine report that a tumor suppressor pathway, called the Hippo pathway, is responsible for sensing abnormal chromosome numbers in cells and triggering cell cycle arrest, thus preventing progression into cancer.
NIH/National Cancer Institute

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center

Public Release: 14-Aug-2014
Cell
Genetic signal prevents immune cells from turning against the body
Salk scientists find a control signal for the immune system that could help treat autoimmune diseases and cancer.

Contact: Salk Communications
press@salk.edu
Salk Institute

Public Release: 14-Aug-2014
Cancer Research
Protein found to block benefits of vitamin A cancer therapy
Retinoic acid is a form of vitamin A that is used to treat and help prevent the recurrence of a variety of cancers, but for some patients the drug is not effective. The reason for this resistance was unclear until this week when researchers from Virginia Commonwealth University Massey Cancer Center demonstrated that a protein known as AEG-1 blocks the effects of retinoic acid in leukemia and liver cancer.
National Institutes of Health, James S. McDonnel Foundation

Contact: Alaina Schneider
afschneider@vcu.edu
804-628-4578
Virginia Commonwealth University

Public Release: 14-Aug-2014
Cancer Research
Aspirin may slow recurrence in breast cancer patients
New findings published in the journal Cancer Research reveal some postmenopausal overweight breast cancer patients who use anti-inflammatory drugs like aspirin or ibuprofen have significantly lower breast cancer recurrence rates. Anti-inflammatory use reduced the recurrence of ERα positive breast cancer by 50 percent and extended patients' disease-free period by more than two years. Research was performed at the Cancer Therapy & Research Center at the University of Texas Health Science Center San Antonio and University of Texas Austin.
US Department of Defense, Breast Cancer Research Program, NIH/National Cancer Institute

Contact: Catherine Duncan
duncancl@uthscsa.edu
210-567-2570
University of Texas Health Science Center at San Antonio

Public Release: 14-Aug-2014
Cancer Research
NSAIDs may lower breast cancer recurrence rate in overweight and obese women
Recurrence of hormone-related breast cancer was cut by half in overweight and obese women who regularly used aspirin or other nonsteroidal anti-inflammatory drugs, according to data published in Cancer Research, a journal of the American Association for Cancer Research.
NIH/National Cancer Institute, Department of Defense, Breast Cancer Research Program

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 14-Aug-2014
Nature Communications
Immune cell discovery could help to halt cancer spread
Melbourne researchers have revealed the critical importance of highly specialized immune cells, called natural killer cells, in killing melanoma cells that have spread to the lungs. These natural killer cells could be harnessed to hunt down and kill cancers that have spread in the body. The team, from the Walter and Eliza Hall Institute, also found natural killer cells were critical to the body's rejection of donor bone marrow transplants and in the runaway immune response during toxic shock syndrome.
Australian National Health and Medical Research Council, Menzies Foundation, Victorian Government

Contact: Liz Williams
williams@wehi.edu.au
61-428-034-089
Walter and Eliza Hall Institute

Public Release: 14-Aug-2014
Nature Medicine
Novel treatment strengthens bones in genetic disease neurofibromatosis type-1
An enzyme therapy may prevent skeletal abnormalities associated with the genetic disorder neurofibromatosis type-1, Vanderbilt investigators have discovered. The researchers demonstrated in a mouse model of the disorder that the enzyme asfotase-alpha improves bone growth, mineralization and strength. Their findings are published in the August issue of Nature Medicine.
Children's Tumor Foundation, National Institutes of Health

Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center

Public Release: 14-Aug-2014
Cancer Research
New Irish research sheds light on how aspirin works to reduce cancer deaths
Researchers have discovered that women who had been prescribed aspirin regularly before being diagnosed with breast cancer are less likely to have cancer that spread to the lymph nodes than women who were not on prescription aspirin. These women are also less likely to die from their breast cancer.
Health Research Board (Ireland), Irish Cancer Society

Contact: Yolanda Kennedy
yokenned@tcd.ie
353-896-3551
Trinity College Dublin

Public Release: 14-Aug-2014
Cell
Inside the cell, an ocean of buffeting waves
Harvard-led researchers put forth a new model of the cytoplasm as a gel, not a liquid, and demonstrate that ATP-driven processes are indirectly responsible for transport within the cell. A measurement of the spectrum of forces exerted on the cytoplasm at any given time can provide a snapshot of the metabolic state of the cell.
National Institutes of Health, National Science Foundation, Netherlands Organization for Scientific Research, Hannah's Hope Fund

Contact: Caroline Perry
cperry@seas.harvard.edu
617-496-1351
Harvard University

Public Release: 14-Aug-2014
JAIDS: Journal of Acquired Immune Deficiency Syndromes
Scientists detail urgent research agenda to address chronic disease toll
According to recommendations resulting from a multidisciplinary conference sponsored by the National Institutes of Health, scientists and physicians in low- and middle-income countries should build on existing HIV research to study and treat chronic conditions.

Contact: Jeff Gray
Jeffrey.Gray@nih.gov
301-496-2075
NIH/Fogarty International Center

Public Release: 13-Aug-2014
Science Translational Medicine
Bacterial biosurgery shows promise for reducing the size of inoperable tumors
Deep within most tumors lie areas that remain untouched by chemotherapy and radiation. These troublesome spots lack the blood and oxygen needed for traditional therapies to work, but provide the perfect target for a new cancer treatment using bacteria that thrive in oxygen-poor conditions. Now, researchers have shown that injections of a weakened version of one such anaerobic bacteria -- the microbe Clostridium novyi -- can shrink tumors in rats, pet dogs, and a human patient.
BioMed Valley Discoveries, Inc., Virginia and D.K. Ludwig Fund for Cancer Research, Maryland Cigarette Restitution Fund, Commonwealth Fund, Swim Across America, Burroughs Wellcome Career Award for Medical Scientists

Contact: Kim Bland, Ph.D.
mediacontact@biomed-valley.com
816-389-8848
Stowers Institute for Medical Research

Public Release: 13-Aug-2014
Nature Communications
Scientists make major breakthrough in understanding leukemia
Scientists from Queen Mary University of London have discovered mutations in genes that lead to childhood leukemia of the acute lymphoblastic type -- the most common childhood cancer in the world.

Contact: Charli Scouller
c.scouller@qmul.ac.uk
020-788-27943
Queen Mary, University of London

Public Release: 13-Aug-2014
Science Translational Medicine
Injected bacteria shrink tumors in rats, dogs and humans
A modified version of the Clostridium novyi (C. novyi-NT) bacterium can produce a strong and precisely targeted anti-tumor response in rats, dogs and now humans, according to a new report from Johns Hopkins Kimmel Cancer Center researchers.
BioMed Valley Discoveries Inc., Virginia and D.K. Ludwig Fund for Cancer Research, Maryland Cigarette Restitution Fund, Commonwealth Fund, Swim Across America, Burroughs Wellcome Career Award for Medical Scientists, Voices Against Brain Cancer

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 13-Aug-2014
Cancer Epidemiology, Biomarkers & Prevention
Exercise associated with reduced risk of breast cancer in African-American women
Regular exercise, including brisk walking, is associated with a decrease in the incidence of breast cancer in African American women. In a recently published study in Cancer Epidemiology, Biomarkers & Prevention, researchers from Boston University's Slone Epidemiology Center found strong evidence linking physical exercise to a lower rate of breast cancer in African-American women, a group in which previous evidence has been lacking.
NIH/National Cancer Institute

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center

Public Release: 13-Aug-2014
Cancer Epidemiology, Biomarkers & Prevention
Prostate Cancer Prevention Trial identifies men mostly likely to undergo challenging study procedure
Healthy men participating in the Prostate Cancer Prevention Trial who actively participate in all steps of the clinical trial are most likely to undergo a biopsy, according to a study published in Cancer Epidemiology, Biomarkers and Prevention -- a journal of the American Association for Cancer Research.

Contact: Katrina Burton
kburton@mdanderson.org
713-792-8034
University of Texas M. D. Anderson Cancer Center

Public Release: 13-Aug-2014
Nature Communications
NTU gene research promises better treatment procedures for children with leukemia
A research team led by Nanyang Technological University scientists have made a key finding which is expected to open up improved treatment possibilities for children suffering from leukemia.

Contact: Lester Kok
lesterkok@ntu.edu.sg
65-679-06804
Nanyang Technological University

Public Release: 12-Aug-2014
Neoplasia
Hijacking the brain's blood supply: Tumor discovery could aid treatment
Dangerous brain tumors hijack the brain's existing blood supply throughout their progression, by growing only within narrow potential spaces between and along the brain's thousands of small blood vessels, new research shows for the first time.
NIH/National Institute of Neurological Diseases and Stroke

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 12-Aug-2014
Analyst
New analysis reveals tumor weaknesses
Epigenetic markers in cancer cells could improve patient treatment.
National Science Foundation, Burroughs Wellcome Fund, NIH/National Institute for Environmental Health Sciences, James H. Ferry Fund for Innovation

Contact: Andrew Carleen
acarleen@mit.edu
617-253-1682
Massachusetts Institute of Technology

Public Release: 12-Aug-2014
European Urology
Less radical procedures offer similar cancer control for kidney cancer patients
Needle-guided tumor destruction procedures offer near equivalent lengths of local cancer control compared to surgery for patients with small kidney cancer tumors, according to the results of a large study published in the journal European Urology. 'If validated, these data suggest that an update to clinical guidelines would be warranted,' says the study's lead author, R. Houston Thompson, M.D., a Mayo Clinic urologist.

Contact: Joe Dangor
newsbureau@mayo.edu
507-284-5005
Mayo Clinic

Public Release: 12-Aug-2014
Journal of Cancer Survivorship
Beating childhood cancer does not make survivors healthier adults
Having survived cancer as a child does not necessarily have a ripple effect that makes people lead a healthier lifestyle once they grow up.

Contact: Alexander K. Brown
alexander.brown@springer.com
212-620-8063
Springer Science+Business Media

Showing releases 76-100 out of 1244.

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