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Showing releases 76-100 out of 1136.

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Public Release: 19-Nov-2012
Proceedings of the National Academy of Sciences
'Different kind of stem cell' possesses attributes favoring regenerative medicine
A research team at Georgetown say the new and powerful cells they first created in the laboratory a year ago constitute a new stem-like state of adult epithelial cells. They report that these new stem-like cells do not don't produce tumors when they grow in the laboratory, as the other stem cells do, and why they are stable, producing the kind of cells researchers want them to.
National Institutes of Health

Contact: Karen Mallet
km463@georgetown.edu
Georgetown University Medical Center

Public Release: 19-Nov-2012
Journal of Clinical Investigation
A code of silence in acute myeloid leukemia
In a study published in the Journal of Clinical Investigation, researchers led by Daniel Tenen at Beth Israel Deaconess Medical Center found that a transcriptional regulator known as C/EBPG was highly expressed in a subset of AML samples that had an epigenetically silenced C/EBPA gene.
National Institutes of Health, European Hematology Association

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 19-Nov-2012
DREAM 2012
Can breast cancer cells' reaction to cancer drugs be predicted?
Finnish researchers have developed a triumphant solution for predicting responses of breast cancer cells to a set of cancer drugs. The prediction is based on the genomic profiles of the cancer cells.

Contact: Samuel Kaski
samuel.kaski@hiit.fi
358-503-058-694
Aalto University

Public Release: 19-Nov-2012
Molecular Ecology
University of East Anglia research shows telomere lengths predict life expectancy in the wild
Researchers at the University of East Anglia have found that biological age and life expectancy can be predicted by measuring an individual's DNA.
Natural Environment Research Council

Contact: Lisa Horton
l.horton@uea.ac.uk
44-016-035-92764
University of East Anglia

Public Release: 19-Nov-2012
Journal of Clinical Investigation
JCI early table of contents for Nov. 19, 2012
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Nov. 19, 2012, in the JCI: A code of silence in acute myeloid leukemia; Immune cells fail to migrate in Huntington's disease; T cell development remains intact after loss of thymic function; Treating muscle weakness in myotopic dystrophy; HIV-1 infection generates microparticles that kill immune cells; B cells cross the blood-brain barrier in multiple sclerosis; and many more.

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 19-Nov-2012
Environmental Health
Does your job increase your breast cancer risk?
Is there a link between the risk of breast cancer and the working environment? A study published in BioMed Central's open access journal Environmental Health provides further evidence on this previously neglected research topic, confirming that certain occupations do pose a higher risk of breast cancer than others, particularly those that expose the worker to potential carcinogens and endocrine disrupters.

Contact: Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central

Public Release: 19-Nov-2012
Archives of Surgery
Uninsured brain cancer patients may be more likely than insured to die after surgery to remove tumor
Uninsured patients who undergo surgery to remove a brain tumor could be twice as likely to die in the hospital as those who have the same operation but are privately insured, new Johns Hopkins research suggests. In teaching hospitals, where most neurosurgical procedures take place, those with government-subsidized insurance in the form of Medicaid were found in the same study to have rates of survival closer to those who are privately insured.
Doris Duke Charitable Foundation, VSBfonds, Prins Bernhard Cultuurfonds, Robert Wood Johnson Foundation

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine

Public Release: 19-Nov-2012
Archives of Otolaryngology - Head & Neck Surgery
Study examines surgical outcomes after head and neck cancer at safety-net hospitals
Safety-net hospitals appear to provide head and neck cancer surgical care to a vulnerable population, without an increase in short-term mortality, morbidity, or costs.

Contact: David March
dmarch1@jhmi.edu
410-955-1534
JAMA and Archives Journals

Public Release: 19-Nov-2012
Archives of Surgery
Uninsured patients undergoing craniotomy for brain tumor have higher in-hospital mortality
Compared to insured patients, uninsured patients have higher in-hospital mortality following surgery for brain tumors.

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
JAMA and Archives Journals

Public Release: 18-Nov-2012
Nature
Skin cells reveal DNA's genetic mosaic
The prevailing wisdom has been that every cell in the body contains identical DNA. However, a new study of stem cells derived from the skin has found that genetic variations are widespread in the body's tissues, a finding with profound implications for genetic screening, according to Yale School of Medicine researchers.
NIH/National Institute of Mental Health, Simons Foundation, State of Connecticut

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University

Public Release: 16-Nov-2012
Nature Communications
Reconsidering cancer's bad guy
Researchers at the University of Copenhagen have found that a protein, known for causing cancer cells to spread around the body, is also one of the molecules that trigger repair processes in the brain. These findings are the subject of a paper, published this week in Nature Communications. They point the way to new avenues of research into degenerative brain diseases like Alzheimer's.

Contact: Professor Vladimir Berezin
berezin@sund.ku.dk
(45) 35-32-73-35
University of Copenhagen

Public Release: 16-Nov-2012
Nature
DNA packaging discovery reveals principles by which CRC mutations may cause cancer
A new discovery from researchers at Huntsman Cancer Institute at the University of Utah concerning a fundamental understanding about how DNA works will produce a "180-degree change in focus" for researchers who study how gene packaging regulates gene activity, including genes that cause cancer and other diseases.
National Institutes of Health, Howard Hughes Medical Institute

Contact: Linda Aagard
801-587-7639
University of Utah Health Sciences

Public Release: 15-Nov-2012
Structure of enzyme unravelled providing basis for more accurate design of chemotherapeutic drugs
A group of researchers at the University of California, Berkeley have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs.

Contact: Meghan Jendrysik
M.Jendrysik@Elsevier.com
617-397-2845
Elsevier

Public Release: 15-Nov-2012
World Health Organisation’s Framework Convention on Tobacco Control
Tobacco Control
Cash cuts increase smoking death risk for world's poor, study says
Proposed funding cuts within the international body responsible for tobacco control will leave the world's poorest countries more vulnerable to smoking-related diseases, a study suggests.

Contact: Edd McCracken
edd.mccracken@ed.ac.uk
44-013-165-14400
University of Edinburgh

Public Release: 15-Nov-2012
Molecular Cell
Scientists show protein-making machinery can switch gears with a small structural change process, which may have implications for immunity and cancer therapy, compared to the movie The Transformers
For the past several years, Min Guo, an assistant professor at The Scripps Research Institute, has focused on the intricate actions of an ancient family of catalytic enzymes that play a key role in translation, the process of producing proteins. in a new study, Guo, Ehud Razin of The Institute for Medical Research Israel-Canada, and a large team of international scientists have shown that this enzyme can actually also work in another fundamental process in humans.
National Institutes of Health, National Science Foundation, National Foundation for Cancer Research, Global Frontier Project, Ministry of Education

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute

Public Release: 15-Nov-2012
Cell Cycle
Dietary glucose affects the levels of a powerful oncogene in mice
In this study, researchers help establish the mechanisms of why a low carbohydrate diet slows tumor growth in mice. The findings do not mean that cancer patients should cut back on the sugar in their diets, but it does pose questions about the consequences of diet on increased activity of an oncogene that drives tumor growth.
NIH/National Cancer Institute, NIH/National Institutes of Health

Contact: Karen Mallet
km463@georgetown.edu
Georgetown University Medical Center

Public Release: 15-Nov-2012
Biological Chemistry
GW Research chosen as 'paper of the week' for blood coagulation discovery
Researchers at the George Washington University School of Medicine and Health Sciences will be featured as a top paper in next week's issue of the Journal of Biological Chemistry for their groundbreaking discovery of a new regulator of the blood coagulation cascade. 

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University

Public Release: 15-Nov-2012
Cancer Research
Potential new technique for anticancer radiotherapy could provide alternative to brachytherapy
New approach could be alternative to surgical implantation of radioactive "seeds." Injected radioactive substance was retained in tumors in mice. Tumor growth was delayed in all treated animals.

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 15-Nov-2012
Genes and Development
Study offers clues to cause of kids' brain tumors
Insights from a genetic condition that causes brain cancer are helping scientists better understand the most common type of brain tumor in children.

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine

Public Release: 15-Nov-2012
Journal of Thoracic Oncology
Study shows large-scale genomic testing feasible, impacts therapy
Targeted cancer therapy has been transforming the care of patients with non-small-cell lung cancer (NSCLC). It is now standard practice for tumor specimens from NSCLC patients to be examined for EGFR mutations and ALK rearrangements to identify patients for therapy with EGFR and ALK inhibitors, respectively. Now, researchers say large-scale genomic testing is feasible within the clinical workflow, impacting therapeutic decisions.

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Public Release: 15-Nov-2012
Journal of Thoracic Oncology
Study shows bone metastases treatment can improve overall survival
One of the most frequent sites of metastases is the bone, with an estimated 30 to 40 percent of patients with non-small-cell lung cancer developing bone loss. A study published in the December 2012 issue of the International Association for the Study of Lung Cancer's Journal of Thoracic Oncology, shows that the bone metastases drug denosumab was associated with improved overall survival compared with zoledonic acid.

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Public Release: 15-Nov-2012
Journal of Thoracic Oncology
Study shows different approach after progression in non-small cell lung cancer patients
A new study published in the December 2012 issue of the International Association for the Study of Lung Cancer's Journal of Thoracic Oncology, shows that other approaches to overcome acquired resistance should be considered.

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Public Release: 15-Nov-2012
Cell Transplantation
Human umbilical cord blood cell co-culture supports embryonic stem cell expansion
Co-cultures used for human embryonic stem cell expansion prior to cell transplantation that employ an animal based "feeder" can create a risk by transmitting non-human materials and unknown pathogens. To solve this problem, human tissues can be used as feeders. To feed the sustained culture, researchers in Taiwan developed a "safe, feasible and robust co-culture system" supplied by human umbilical cord mesenchymal stem cells. The co-culture appears to eliminate the propensity to form tumors.
National Science Council of the Republic of China, Taiwan

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair

Public Release: 15-Nov-2012
Stem Cells
Study reveals insights that could aid in therapeutic use of mesenchymal stem cells
Research reveals new insights into how mesenchymal stem cells "traffic" from the circulation into the tissue, providing important clues that could be used to improve the delivery of this promising therapy.
National Institues of Health, American Heart Association, Roche Organ Transplant Research Organization

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center

Public Release: 15-Nov-2012
Preventing Chronic Disease
ACA: More than a million women could gain access to potentially life saving tests for cancer
A study by researchers at the George Washington University School of Public Health and Health Services indicates that full implementation of the Affordable Care Act would expand health insurance coverage for more low-income women, enabling more than a million women to obtain potentially life-saving screening for breast and cervical cancer. The study, "Health Care Reform and Women's Insurance Coverage for Breast and Cervical Cancer Screening," was published in a recent issue of the journal Preventing Chronic Disease.

Contact: Kathy Fackelmann
kfackelmann@gwu.edu
202-994-8354
George Washington University

Showing releases 76-100 out of 1136.

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