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Public Release: 22-Apr-2014
JAMA Internal Medicine
False-positive mammogram anxiety has limited impact on women's well-being
Dartmouth researchers have found that the anxiety experienced with a false-positive mammogram is temporary and does not negatively impact a woman's overall well-being. Their findings are reported in 'Consequences of False-Positive Screening Mammograms,' which was published online in the April 21, 2014, JAMA Internal Medicine.
NIH/National Cancer Institute

Contact: Robin Dutcher
Robin.Dutcher@hitchcock.org
603-653-9056
The Geisel School of Medicine at Dartmouth

Public Release: 22-Apr-2014
ACS Nano
Cloaked DNA nanodevices survive pilot mission
By mimicking a viral strategy, scientists at Harvard's Wyss Institute for Biologically Inspired Engineering have created the first cloaked DNA nanodevice that survives the body's immune defenses. Their success opens the door to smart DNA nanorobots that use logic to spot cancerous tissue and manufacture drugs on the spot to cripple it, as well as artificial microscopic containers called protocells that detect pathogens in food or toxic chemicals in drinking water.

Contact: Dan Ferber
dan.ferber@wyss.harvard.edu
617-432-1547
Wyss Institute for Biologically Inspired Engineering at Harvard

Public Release: 21-Apr-2014
Proceedings of the National Academy of Sciences
Scientists find key steps linking dietary fats and colon cancer tumor growth
Scientists have shown new genetic evidence that could strengthen the link between the role of dietary fats with colon cancer progression. The study, led by Arizona State University researcher and physician Dr. Raymond DuBois, M.D., Ph.D., has identified a molecular culprit, called peroxisome proliferator-activated receptor delta, that, when deleted in a mouse model of colon cancer, stopped key steps required for the initiation and progression of tumor growth.
National Institutes of Health

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-258-8972
Arizona State University

Public Release: 21-Apr-2014
Proceedings of the National Academy of Sciences
Fast, simple-to-use assay reveals the 'family tree' of cancer metastases
A Mass. General Hospital-based research team has developed a simple assay that can reveal the evolutionary relationships between primary tumors and metastases within a patient, information that may someday help with treatment planning.
US Department of Defense

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital

Public Release: 21-Apr-2014
Proceedings of the National Academy of Sciences
'Dustman' protein helps bin cancer cells
Cancer researchers have discovered a new 'dustman' role for a molecule that helps a drug kill cancer cells according to a study, published in the journal Proceedings of the National Academy of Sciences.
Cancer Research UK

Contact: Paul Thorne
paul.thorne@cancer.org.uk
44-203-469-8352
Cancer Research UK

Public Release: 21-Apr-2014
JAMA Internal Medicine
False-positive mammograms associated with anxiety, willingness for future screening
Mammograms with false-positive results were associated with increased short-term anxiety for women, and more women with false-positive results reported that they were more likely to undergo future breast cancer screening.

Contact: Linda Kennedy
Linda.S.Kennedy@Dartmouth.edu
603-653-3612
The JAMA Network Journals

Public Release: 21-Apr-2014
Stem Cell Reports
A protein required for integrity of induced pluripotent stem cells
A study published today in the journal Stem Cell Reports, from the Cell Publishing Group, reveals that the SIRT1 protein is needed to lengthen and maintain telomeres during cell reprogramming. SIRT1 also guarantees the integrity of the genome of stem cells that come out of the cell reprogramming process; these cells are known as induced pluripotent stem cells.

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 21-Apr-2014
Science Signaling
A gene within a gene contributes to the aggressiveness of acute myeloid leukemia
A small gene that is embedded in a larger gene plays a much greater role in promoting acute myeloid leukemia than the better-known host gene, according to a new study by Ohio State University cancer researchers. The research also identified a drug that inhibits expression of the smaller gene.
NIH/National Cancer Institute, Coleman Leukemia Research Foundation, Pelotonia Fellowship Program

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Wexner Medical Center

Public Release: 21-Apr-2014
Journal of Health Communication
IU study: Death of public figures provides important opportunities for health education
An Indiana University study of reactions to the 2011 death of Apple co-founder Steve Jobs suggests health communicators have a critical window of opportunity after a public figure dies to disseminate information about disease prevention and detection.

Contact: Jessica Gall Myrick
jgmyrick@indiana.edu
812-856-7380
Indiana University

Public Release: 21-Apr-2014
Proceedings of the National Academy of Sciences
Malfunction in molecular 'proofreader' prevents repair of UV-induced DNA damage
Malfunctions in the molecular 'proofreading' machinery, which repairs structural errors in DNA caused by ultraviolet light damage, help explain why people who have the disease xeroderma pigmentosum are at an extremely high risk for developing skin cancer, according to researchers at the University of Pittsburgh School of Medicine and the University of Pittsburgh Cancer Institute. Their findings will be published in the early online version of the Proceedings of the National Academy of Sciences.
University of Pittsburgh Cancer Institute, National Institutes of Health

Contact: Anita Srikameswaran
srikamav@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences

Public Release: 20-Apr-2014
Nature Biotechnology
Computational method dramatically speeds up estimates of gene expression
With gene expression analysis growing in importance for both basic researchers and medical practitioners, researchers at Carnegie Mellon University and the University of Maryland have developed a new computational method that dramatically speeds up estimates of gene activity from RNA sequencing data.
National Science Foundation, National Institutes of Health

Contact: Byron Spice
bspice@cs.cmu.edu
412-268-9068
Carnegie Mellon University

Public Release: 20-Apr-2014
Nature Cell Biology
Cancer stem cells linked to drug resistance
Most drugs used to treat lung, breast and pancreatic cancers also promote drug-resistance and ultimately spur tumor growth. Researchers at the University of California, San Diego School of Medicine have discovered a molecule, or biomarker, called CD61 on the surface of drug-resistant tumors that appears responsible for inducing tumor metastasis by enhancing the stem cell-like properties of cancer cells.
National Institutes of Health, NIH/National Cancer Institute

Contact: Yadira Galindo
ygalindo@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 20-Apr-2014
Nature Genetics
Dana-Farber researchers uncover link between Down syndrome and leukemia
A team of researchers led by Dana-Farber Cancer Institute investigators has uncovered a connection between people with Down syndrome and having a heightened risk of developing acute lymphoblastic leukemia during childhood.
Conquer Cancer Foundation, Lauri Strauss Leukemia Foundation, Leukemia and Lymphoma Society

Contact: Teresa Herbert
teresamarieherbert@gmail.com
617-632-4090
Dana-Farber Cancer Institute

Public Release: 18-Apr-2014
Cancer Epidemiology, Biomarkers & Prevention
Chronic inflammation may be linked to aggressive prostate cancer
The presence of chronic inflammation in benign prostate tissue was associated with high-grade, or aggressive, prostate cancer, and this association was found even in those with low prostate-specific antigen levels, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
NIH/National Cancer Institute

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 18-Apr-2014
Cancer Epidemiology, Biomarkers & Prevention
Chronic inflammation linked to 'high-grade' prostate cancer
Men who show signs of chronic inflammation in non-cancerous prostate tissue may have nearly twice the risk of actually having prostate cancer than those with no inflammation, according to results of a new study led by researchers from the Johns Hopkins Kimmel Cancer Center.
NIH/National Cancer Institute

Contact: Michelle Potter
mpotter8@jhmi.edu
410-614-2914
Johns Hopkins Medicine

Public Release: 17-Apr-2014
Journal of Clinical Investigation
New pain relief targets discovered
Scientists have identified new pain relief targets that could be used to provide relief from chemotherapy-induced pain. BBSRC-funded researchers at King's College London made the discovery when researching how pain occurs in nerves in the periphery of the body.
Biotechnology and Biological Sciences Research Council

Contact: Chris Melvin
chris.melvin@bbsrc.ac.uk
01-793-414-694
Biotechnology and Biological Sciences Research Council

Public Release: 17-Apr-2014
PLOS Genetics
New gene variant found increases the risk of colorectal cancer from eating processed meat
A common genetic variant that affects one in three people appears to significantly increase the risk of colorectal cancer from the consumption of processed meat, according to study published today in PLOS Genetics.

Contact: Jane C. Figueiredo
janefigu@usc.edu
PLOS

Public Release: 17-Apr-2014
Developmental Cell
Dual role: Key cell division proteins also power up mitochondria
An international team led by researchers at UC Davis has shown that the cyclin B1/Cdk1 protein complex, which plays a key role in cell division, also boosts the mitochondrial activity to power that process.
DOE Office of Science, National Institutes of Health

Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System

Public Release: 17-Apr-2014
PLOS Genetics
First genetic link discovered to difficult-to-diagnose breast cancer sub-type
The discovery of the genetic variant, in conjunction with other markers, could help in the development of future genetic screening tools to assess women's risk of developing invasive lobular cancer, and also gives researchers important new clues about the genetic causes of the disease and a related precursor to cancer called lobular carcinoma in situ.

Contact: Henry French
henry.french@icr.ac.uk
44-207-153-5582
Institute of Cancer Research

Public Release: 17-Apr-2014
European Journal of Oncology Nursing
Unraveling the 'black ribbon' around lung cancer
A Michigan State University study consisting of lung cancer patients, primarily smokers between the ages of 51 to 79 years old, is shedding more light on the stigma often felt by these patients, the emotional toll it can have and how health providers can help.
Michigan State University College of Nursing

Contact: Sarina Gleason
sarina.gleason@cabs.msu.edu
517-355-9742
Michigan State University

Public Release: 17-Apr-2014
Journal of American College of Surgeons
20 years of data shows treatment technique improvement for advanced abdominal cancer
Wake Forest Baptist has the largest reported, single-center experience with cytoreductive surgery and HIPEC and analysis of 20 years' worth of patient data shows that outcomes have clearly improved for patients undergoing this treatment technique.

Contact: Bonnie Davis
bdavis@wakehealth.edu
336-716-4977
Wake Forest Baptist Medical Center

Public Release: 17-Apr-2014
Journal of Clinical Investigation
JCI online ahead of print table of contents for April 17, 2014
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers published online, April 17, 2014 in the JCI: 'Double-stapled peptide inhibits RSV infection,' 'Fibroblast-derived exosomes mediate caridiomyocyte hypertrophy via microRNA delivery,' 'Patient response to cryptococcosis is dependent on fungal-specific factors,' 'The coinhibitory receptor PD-1H suppresses T cell responses,' 'Type-1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis,' and more.

Contact: Corinne Williams
press_releases@the-jci.org
919-265-3506
Journal of Clinical Investigation

Public Release: 17-Apr-2014
ACS Synthetic Biology
Building 'smart' cell-based therapies
Northwestern University synthetic biologist Joshua Leonard and his team have developed a technology for engineering human cells as therapies that become activated only in diseased tissues.

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University

Public Release: 16-Apr-2014
Clinical Infectious Diseases
HIV+ women respond well to HPV vaccine
A three-nation clinical trial found that a vaccine can safely help the vast majority of HIV-positive women produce antibodies against the cancer-causing human papillomavirus, even if their immune system is weak and even if they've had some prior HPV exposure.
National Institutes of Health

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

Public Release: 16-Apr-2014
Medical Oncology
Radiation therapy for cervical cancer increases risk for colorectal cancer
Researchers at the University of Texas Medical Branch at Galveston are the first to recommend that young women treated with radiation for cervical cancer should begin colorectal cancer screening earlier than traditionally recommended. The UTMB researchers, finding a high incidence of secondary colorectal cancers among cervical cancer survivors treated with radiation, offer new recommendations that the younger women in this group begin colorectal cancer screening about eight years after their initial cervical cancer diagnosis.
Cancer Prevention Research Institute of Texas

Contact: Molly Dannenmaier
mjdannen@utmb.edu
409-772-8790
University of Texas Medical Branch at Galveston

Showing releases 876-900 out of 1242.

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