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Public Release: 22-Aug-2014
Inflammatory Bowel Diseases
Study shows epigenetic changes in children with Crohn's disease
A new study finds a wide range of epigenetic change -- alterations in DNA across the genome that may be related to key environmental exposures -- in children with Crohn's disease, reports Inflammatory Bowel Diseases, official journal of the Crohn's & Colitis Foundation of America. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

Contact: Connie Hughes
Wolters Kluwer Health

Public Release: 22-Aug-2014
Nature Communications
Genetics and lifestyle have a strong impact on biomarkers for inflammation and cancer
In a new study published in Nature Communications, research scientists from Uppsala University present for the first time a large-scale study of the significance of genetic, clinical and lifestyle factors for protein levels in the bloodstream. The results of the study show that genetics and lifestyle are determining factors for protein levels, a discovery which greatly influences the possibilities for using more biomarkers to identify disease.

Contact: Stefan Enroth
Uppsala University

Public Release: 21-Aug-2014
Cancer Cell
Sequence of rare kidney cancer reveals unique alterations involving telomerase
An international scientific collaboration led by Baylor College of Medicine has revealed clues about genetic alterations that may contribute to a rare form of kidney cancer, providing new insights not only into this rare cancer but other types as well.

Contact: Glenna Picton
Baylor College of Medicine

Public Release: 21-Aug-2014
JAMA Otolaryngology Head Neck Surgery
Surgery associated with better survival for patients with advanced laryngeal cancer
Patients with advanced laryngeal cancer appear to have better survival if they are treated with surgery than nonsurgical chemoradiation.

Contact: Sid Dinsay
The JAMA Network Journals

Public Release: 21-Aug-2014
Research offers insight into cellular biology of colorectal cancer
Kristi Neufeld has spent the better part of her career trying to understand the various activities of APC, a protein whose functional loss is thought to initiate roughly 80 percent of all colon polyps.
National Institutes of Health

Contact: Brendan M. Lynch
University of Kansas

Public Release: 20-Aug-2014
JAMA Dermatology
Patient, tumor characteristics for high-mitotic rate melanoma
A study in Australia examined patient and tumor characteristics for melanomas with higher mitotic rates (a marker of tumor cell growth) in an effort to increase earlier detection of this aggressive cancer in patients.

Contact: Sarah Shen
The JAMA Network Journals

Public Release: 20-Aug-2014
Science Translational Medicine
Treating gastric cancer -- with Botox
In an article published in the Aug. 20 edition of Science Translational Medicine, a team of international researchers reports that gastric cancer growth could be suppressed by eliminating the signals sent by nerves that are linked to cancer stem cells. The use of Botox to cut the connection between the nerves and the stem cells made the treatment cheap, safe and efficient.
Research Council of Norway, National Institutes of Health, Norwegian University of Science and Technology, St. Olavs University Hospital

Contact: Duan Chen
Norwegian University of Science and Technology

Public Release: 20-Aug-2014
JAMA Surgery
Patient perspectives on breast reconstruction following mastectomy
Less than 42 percent of women underwent breast reconstruction following a mastectomy for cancer, and the factors associated with foregoing reconstruction included being black, having a lower education level and being older.

Contact: Emily O'Donnell
The JAMA Network Journals

Public Release: 20-Aug-2014
Journal of Urology
Severe infections with hospitalization after prostate biopsy rising in Sweden
Transrectal ultrasound guided biopsy is the gold standard for detecting prostate cancer, but international reports have suggested that the number of risks associated with the procedure is increasing. In a new nationwide population-based study, Swedish researchers found that six percent of men filled a prescription for antibiotics for a urinary tract infection within 30 days after having a prostate biopsy, with a twofold increase in hospital admissions over five years, reports The Journal of Urology.

Contact: Linda Gruner
Elsevier Health Sciences

Public Release: 20-Aug-2014
Cancer Cell
Blueprint for next generation of chronic myeloid leukemia treatment
Researchers at Huntsman Cancer Institute at the University of Utah have identified and characterized mutated forms of the gene that encodes BCR-ABL, the unregulated enzyme driving the blood cancer chronic myeloid leukemia.
NIH/National Cancer Institute, Howard Hughes Medical Institute, Huntsman Cancer Institute, Leukemia & Lymphoma Society, American Society of Hematology

Contact: Linda Aagard
University of Utah Health Sciences

Public Release: 20-Aug-2014
Science Translational Medicine
Severing nerves may shrink stomach cancers: Botox injections slow growth of tumors in mice
Research from Columbia University Medical Center shows that nerves may play a critical role in stomach cancer growth and that blocking nerve signals using surgery or Botox could be an effective treatment for the disease.
National Institutes of Health

Contact: Lucky Tran
Columbia University Medical Center

Public Release: 20-Aug-2014
Pigment Cell & Melanoma Research
Scientists learn more about rare skin cancer that killed Bob Marley
Acral melanomas, the rare type of skin cancer that caused Bob Marley's death, are genetically distinct from other types of skin cancer.
Cancer Research UK

Contact: Flora Malein
Cancer Research UK

Public Release: 19-Aug-2014
Extended support helps patients stay smoke-free after hospital discharge
A Massachusetts General Hospital study in the Aug. 20 issue of JAMA describes a program that increased the proportion of hospitalized smokers who successfully quit smoking after discharge by more than 70 percent. The system used interactive voice response technology to provide support and stop-smoking medication for three months after smokers left the hospital.
National Institutes of Health

Contact: Terri Ogan
Massachusetts General Hospital

Public Release: 19-Aug-2014
BJU International
Deaths rise with shift from in-hospital to outpatient procedures for urology surgeries
As hospitals have shifted an array of common urological surgeries from inpatient procedures to outpatient, potentially preventable deaths have increased following complications. Those were the primary findings of a new study led by Henry Ford Hospital researchers, who initially expected that improved mortality rates recently documented for surgery overall would also translate to commonly performed urologic surgeries. The opposite turned out to be true.

Contact: Dwight Angell
Henry Ford Health System

Public Release: 19-Aug-2014
Natural (born) killer cells battle pediatric leukemia
Researchers at Children's Hospital Los Angeles have shown that a select team of immune-system cells can be multiplied in the lab, creating an army of natural killer cells that can be used to destroy leukemia cells.
Alex's Lemonade Stand Foundation, Leukemia & Lymphoma Society, V-Foundation

Contact: Ellin Kavanagh
Children's Hospital Los Angeles

Public Release: 19-Aug-2014
Journal of Clinical Investigation
Novel gene predicts both breast cancer relapse and response to chemotherapy
Scientists have made it easier to predict both breast cancer relapses and responses to chemotherapy, through the identification of a unique gene. The newly found marker could help doctors classify each breast cancer patient and customize a treatment regimen that is more effective. The discovery was a collaborative effort by scientists from A*STAR's Institute of Molecular and Cell Biology, and the Cancer Science Institute of Singapore at the National University of Singapore.

Contact: Tan Yun Yun
Biomedical Sciences Institutes (BMSI)

Public Release: 19-Aug-2014
Proceedings of the National Academy of Sciences
Biomarker in an aggressive breast cancer is identified
Northwestern University scientists have identified a biomarker strongly associated with basal-like breast cancer, a highly aggressive carcinoma that is resistant to many types of chemotherapy. The biomarker, a protein called STAT3, provides a smart target for new therapeutics designed to treat this often deadly cancer. Using patient data from The Cancer Genome Atlas, the researchers used bioinformatics techniques and found that a small number of genes are activated by STAT3 protein signaling in basal-like breast cancers but not in luminal breast cancers.
H Foundation, NIH/National Cancer Institute

Contact: Megan Fellman
Northwestern University

Public Release: 19-Aug-2014
Markey researchers develop web-based app to predict glioma mutations
A new web-based program developed by University of Kentucky Markey Cancer Center researchers will provide a simple, free way for healthcare providers to determine which brain tumor cases require testing for a genetic mutation.
NIH/National Cancer Institute, Peter and Carmen Lucia Buck Training Program in Translational Clinical Oncology, University of Kentucky College of Medicine Physician Scientist Program

Contact: Allison Perry
University of Kentucky

Public Release: 18-Aug-2014
Proceedings of the National Academy of Sciences
WSU researchers find crucial step in DNA repair
Scientists at Washington State University have identified a crucial step in DNA repair that could lead to targeted gene therapy for hereditary diseases such as 'children of the moon' and a common form of colon cancer. Such disorders are caused by faulty DNA repair systems that increase the risk for cancer and other conditions.
National Institute of Environmental Health Sciences

Contact: Michael Smerdon
Washington State University

Public Release: 18-Aug-2014
JAMA Internal Medicine
Older patients with limited life expectancy still receiving cancer screenings
A substantial number of older patients with limited life expectancy continue to receive routine screenings for prostate, breast, cervical and colorectal cancer although the procedures are unlikely to benefit them.
Doris Duke Charitable Foundation

Contact: Katy Jones
The JAMA Network Journals

Public Release: 18-Aug-2014
Nature Communications
Myc inhibition is an effective therapeutic strategy against most aggressive brain tumors
The Myc protein plays a key role in the development of several tumor types and its inhibition could therefore prove an effective therapy against many different cancers. Previous studies by this same VHIO group successfully blocked Myc through expression of an inhibitor, resulting in the eradication of lung tumors in preclinical models.

Contact: Amanda Wren
Vall d'Hebron Institute of Oncology

Public Release: 18-Aug-2014
Nature Materials
Massachussetts General-developed device monitors key step in development of tumor metastases
A microfluidic device developed at Massachusetts General Hospital may help study key steps in the process by which cancer cells break off from a primary tumor to invade other tissues and form metastases.
Damon Runyon Cancer Research Foundation, Howard Hughes Medical Institute, National Institutes of Health

Contact: Katie Marquedant
Massachusetts General Hospital

Public Release: 18-Aug-2014
Nature Nanotechnology
MIPT and RAS scientists made an important step towards creating medical nanorobots
Researchers at Moscow Institute of Physics and Technology and Russian Academy of Sciences made an important step towards creating medical nanorobots discovering a way of enabling them to produce logical calculations using a variety of biochemical reactions.

Contact: Alexandra O. Borissova
Moscow Institute of Physics and Technology

Public Release: 18-Aug-2014
Molecular Carcinogenesis
Leukemia drug shows promise for skin, breast and other cancers
A leukemia drug called dasatinib shows promise for treating skin, breast and several other cancers, according to researchers at Loyola University Chicago Stritch School of Medicine.

Contact: Jim Ritter
Loyola University Health System

Public Release: 18-Aug-2014
Cancer Cell
New mouse model points to therapy for liver disease
In a paper published online in Cancer Cell, scientists at the University of California, San Diego School of Medicine describe a novel mouse model that closely resembles human NASH and use it to demonstrate that interference with a key inflammatory protein inhibits both the development of NASH and its progression to liver cancer.
National Institutes of Health, Superfund Basic Research Program, Daiichi Sankyo Foundation of Life Science and Grant-in-Aid for Scientific Research, Astellas Foundation for Research

Contact: Scott LaFee
University of California - San Diego

Showing releases 876-900 out of 1265.

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