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Public Release: 11-Apr-2016
Man and life: How marriage, race and ethnicity and birthplace affect cancer survival
Previous studies have shown that married patients with cancer fare better than unmarried cancer patients, surviving more often and longer. In a new study, published April 11 in the journal Cancer, researchers at University of California, San Diego School of Medicine report that the benefits of being married vary by race and ethnicity, with male non-Hispanic white bachelors experiencing the worst outcome.
Stanford Cancer Institute, NIH/National Cancer Institute, Specialized Cancer Center Support Grant

Contact: Yadira Galindo
University of California - San Diego

Public Release: 11-Apr-2016
Cancer Cell
New public repository of patient-derived cancer models aims to improve drug testing
Testing experimental cancer drugs in mouse models with patient-derived tumors could reduce the high failure rate of drugs in early clinical trials, according to a report from Dana-Farber Cancer Institute scientists.
Leukemia and Lymphoma Society, Stand Up To Cancer

Contact: Teresa Herbert
Dana-Farber Cancer Institute

Public Release: 11-Apr-2016
Annals of Internal Medicine
USPSTF publishes recommendation on taking aspirin to prevent heart attack, stroke, and colorectal cancer
The US Preventive Services Task Force recommends that people who are 50-69 years old, have increased risk of cardiovascular disease (CVD), and who are not at increased risk for bleeding, consider taking aspirin for primary prevention of CVD and colorectal cancer. The full recommendation and evidence reviews are published in Annals of Internal Medicine.

Contact: Cara Graeff
American College of Physicians

Public Release: 11-Apr-2016
Cancer Cell
Mapping the routes to drug resistance in cancer
When a targeted therapy blocks a pathway that enables tumors to grow, the cells usually manage to get around that obstacle. The result is drug resistance. Researchers have now found a way to map those alternate routes by studying individual cancer cells, suggesting approaches for developing more effective combination therapies. The results are published April 11 in Cancer Cell.

Contact: Joseph Caputo
Cell Press

Public Release: 11-Apr-2016
Journal of Urology
More than 3 percent of men on active surveillance for prostate cancer may have metastases
Active surveillance of prostate cancer is increasingly accepted as an option for treating patients with clinically insignificant disease to maintain their quality of life. Despite close monitoring, however, metastatic disease develops in a small number of men on active surveillance. About 3 percent of patients on surveillance had metastasis by a median of seven years after diagnosis. This risk increased to ten percent in patients with Gleason score (GS) 7, according to new research published in The Journal of Urology.

Contact: Eileen Leahy
Elsevier Health Sciences

Public Release: 11-Apr-2016
Journal of Clinical Oncology
PET scans guiding chemo boosts remission for Hodgkin patients
Using PET imaging to guide chemotherapy treatment significantly increases the number of people who go into remission and also decreases toxic side effects for people with advanced Hodgkin lymphoma, according to research conducted by SWOG and two other National Cancer Institute research groups.
NIH/National Cancer Institute, The David and Patricia Giuliani Family Foundation, Lymphoma Foundation, Adam Spector Fund for Hodgkin Research, and Ernest & Jeanette Dicker Charitable Foundation

Contact: Wendy Lawton

Public Release: 11-Apr-2016
Being married may help prolong survival in cancer patients
New research has uncovered a link between being married and living longer among cancer patients, with the beneficial effect of marriage differing by race/ethnicity and place of birth.

Contact: Dawn Peters

Public Release: 11-Apr-2016
Journal of Clinical Oncology
Omega factor: Novel method measures mortality risk when multiple diseases threaten
Researchers at the University of California, San Diego School of Medicine have developed a novel method for assessing mortality risk in elderly patients with cancer who also suffer from other serious diseases or conditions. The prognostic model, they say, is more precise and provides a more useful tool for determining the best treatments when more than one disease is involved.
National Institutes of Health

Contact: Scott LaFee
University of California - San Diego

Public Release: 11-Apr-2016
Journal of Thoracic Oncology
A novel mechanism of crizotinib resistance in a ROS1+ NSCLC patient
Molecular analysis of a tumor biopsy from a proto-oncogene 1 receptor tyrosine kinase positive (ROS1+) patient with acquired crizotinib resistance revealed a novel mutation in the v-kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog receptor tyrosine kinase (KIT) that can potentially be targeted by KIT inhibitors.

Contact: Jeff Wolf
International Association for the Study of Lung Cancer

Public Release: 11-Apr-2016
Macrophages surrounding lymph nodes block the progression of melanoma, other cancers
Researchers at Massachusetts General Hospital have identified a type of immune cell that appears to block the progress of melanoma and other cancers in animal models.
Samana Cay MGH Research Scholar Fund, National Institutes of Health

Contact: Julie Cunningham
Massachusetts General Hospital

Public Release: 11-Apr-2016
Research Ideas & Outcomes
Pericardial window operation less efficient in cases of lung cancer than any other cancer
Pericardial window operation, a procedure, where abnormal quantity of malignant fluid, surrounding the heart, is drained into the neighbouring chest cavity, is commonly applied to patients diagnosed with cancer. Taiwanese specialists have now looked into the electronic medical records from a hospital and concluded that the treatment is not as effective in lung cancer cases when compared to any other cancer patients. Their research is published in the open access journal Research Ideas and Outcomes.

Contact: Robert J. Chen
Pensoft Publishers

Public Release: 11-Apr-2016
Cancer Cell
A different route to drug resistance
A team of researchers, led by Ludwig Cancer Research scientist Paul Mischel and James Heath of the California Institute of Technology, has probed biochemical signaling cascades within individual cancer cells to capture a previously poorly understood but clinically significant mechanism of cancer drug resistance.
Ludwig Cancer Research, Ben and Catherine Ivy Foundation Fund, National Institutes of Health, Phelps Family Foundation, National Brain Tumor Society

Contact: Rachel Steinhardt
Ludwig Institute for Cancer Research

Public Release: 8-Apr-2016
Science Advances
Scientists discover how Chinese medicinal plant makes anti-cancer compound
New research reveals how a plant used in traditional Chinese medicine produces compounds which may help to treat cancer and liver diseases.

Contact: Geraldine Platten
John Innes Centre

Public Release: 8-Apr-2016
Cell Reports
Controlling 'bad cholesterol' production could prevent growth of tumors, study finds
Several studies have recognized a link between obesity and cancer. Richard Lehner, professor of Pediatrics and investigator at the University of Alberta's Faculty of Medicine & Dentistry, has taken his research further to understand how tumour cells grow through scavenging very low-density lipoproteins (VLDL) and low-density lipoproteins (LDL), commonly known as the 'bad cholesterol', and what mechanisms can be used to reduce the malignant cells' growth.
Canadian Institutes of Health Research, Austrian Science Fund, Women and Children Health Research Institute, Canada Foundation for Innovation

Contact: Ross Neitz
University of Alberta Faculty of Medicine & Dentistry

Public Release: 8-Apr-2016
Stem Cells and Development
Discovery of CTLA-4 in dendritic cells opens new possibilities to fight cancer
CTLA-4 is also produced and secreted by dendritic cells.

Contact: Jeannette Jimenez
Baylor College of Medicine

Public Release: 8-Apr-2016
Nano Letters
Dressed to kill: Tailoring a suit for tumor-penetrating cancer meds
Tiny capsules, called nanoparticles, are now being used to transport chemotherapy medicine to cancerous tumors. Drexel University researchers believe that the trick to gaining access to the pernicious cellular masses is to give these nanoparticles a new look.

Contact: Britt Faulstick
Drexel University

Public Release: 7-Apr-2016
Molecular Carcinogenesis
Study suggests epiregulin as a target in lung cancer
A University of Colorado Cancer Center study recently published in the journal Molecular Carcinogenesis points to a new potential biomarker and target in lung cancer, namely epiregulin, an under-studied EGF-like growth factor.
American Cancer Society

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 7-Apr-2016
BJU International
Technique may reduce complications in elderly patients undergoing bladder cancer surgery
A retrospective study indicates that for certain elderly patients undergoing surgery for bladder cancer, diverting urine from the bladder can be safely achieved with what's known as a cutaneous ureterostomy with a single stoma rather than the commonly used ileal conduit.

Contact: Dawn Peters

Public Release: 7-Apr-2016
Journal of National Cancer Institute
Cancer thwarts treatment by 'stealing' blood vessels
Cancers can resist treatment by 'stealing' blood vessels from nearby tissues, a new study shows.
Canadian Institutes for Health Research, Worldwide Cancer Research, Canadian Liver Cancer Foundation and Breast Cancer Now

Contact: Henry French
Institute of Cancer Research

Public Release: 7-Apr-2016
Molecular Cell
CNIO scientists discover a new mechanism of resistance to chemotherapy
Óscar Fernández-Capetillo's team reports that ATR kinase inhibitors are more effective in cells with high levels of CDC25A protein expression. ATR inhibitors were previously developed at the CNIO by Fernández-Capetillo's team in collaboration with the Experimental Therapeutics Programme. The finding facilitates the identification of patients that could benefit from ATR kinase inhibitor therapy. This study has been published this week in 'Molecular Cell.'

Contact: Nuria Noriega
Centro Nacional de Investigaciones Oncológicas (CNIO)

Public Release: 7-Apr-2016
Cancer Research
New predictive tool for assessing breast cancer risk
Harvard Stem Cell Institute researchers at Dana-Farber Cancer Institute and collaborators at Brigham and Women's Hospital found that women were five times as likely to develop cancer if they had a higher percentage of Ki67, a molecular marker that identifies proliferating cells, in the cells that line the mammary ducts and milk-producing lobules. These cells, called the mammary epithelium, undergo drastic changes throughout a woman's life, and the majority of breast cancers originate in these tissues.
NIH/National Cancer Institute, Avon Foundation, CJL Foundation, US Army, Susan G. Komen Foundation

Contact: BD Colen
Harvard Medical School

Public Release: 7-Apr-2016
Science Translational Medicine
Common prostate cancer treatments suppress immune response and may promote relapse
Prostate cancer patients and their doctors may want to think twice about the best timing for chemotherapy or radiation therapy in conjunction with a common nonsurgical treatment, based on international research findings led by UT Southwestern Medical Center investigators.
National Institutes of Health, China's Ministry of Science and Technology

Contact: Debbie Bolles
UT Southwestern Medical Center

Public Release: 7-Apr-2016
International Journal of Radiation Oncology, Biology, Physics
More guidelines, uniformity in RT needed following chemotherapy, surgery in breast cancer
Wide variability exists in radiation treatment decisions following neoadjuvant chemotherapy and surgery for breast cancer, according to a review of the American College of Surgeons Oncology Group Z1071, a prospective trial. ACOSOG is now part of the Alliance for Clinical Trials in Oncology.

Contact: Erin L. Boyle
American Society for Radiation Oncology

Public Release: 7-Apr-2016
Molecular Cell
Function of mysterious RNAs may often lie in their genes
Reporting in the journal Molecular Cell, the scientists determined that one prominent long non-coding RNA may be a 'red herring,' with no evident biological role to play -- whereas the DNA from which it originates does perform an important function, as an 'enhancer' that stimulates the expression of an important protein-coding gene nearby.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases, UK Medical Research Council

Contact: Steve Graff
University of Pennsylvania School of Medicine

Public Release: 7-Apr-2016
Proceedings of the National Academy of Sciences
UCI study finds safer stem cell-derived therapy for brain radiation recovery
While stem cells have shown promise for treating brain regions damaged by cancer radiation treatments, University of California, Irvine researchers have found that microscopic vesicles isolated from these cells provide similar benefits without some of the risks associated with stem cells.
Defense Threat Reduction Agency, American Cancer Society, NASA, National Institutes of Health, UCI Institute for Clinical & Translational Science

Contact: Tom Vasich
University of California - Irvine

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