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Public Release: 29-Jul-2015
BMC Medicine
Black men are at double the risk of prostate cancer compared to white men
Black men in England are at double the lifetime risk of being diagnosed with, and dying from, prostate cancer compared with white men in England, according to research published in the open-access journal BMC Medicine. The study also finds that Asian men have around half the lifetime risk of being diagnosed with, and dying from, prostate cancer compared with white men in England.

Contact: Joel Winston
BioMed Central

Public Release: 29-Jul-2015
Human Molecular Genetics
Long telomere length associated with increased lung cancer risk
A large-scale genetic study of the links between telomere length and risk for five common cancers finds that long telomeres are associated with an increased risk of lung adenocarcinoma. No significant associations between telomere length and other cancer types were observed. The study uses a novel method to measure genetic predisposition for telomere length, rather than physiological measures which are confounded by factors such as age and lifestyle.
NIH/National Cancer Institute, NIH/National Institute on Aging, Cancer Research Foundation, Wellcome Trust, National Health and Medical Research Council

Contact: Kevin Jiang
University of Chicago Medical Center

Public Release: 29-Jul-2015
Scientists identify gene vital for rebuilding intestine after cancer treatment
Scientists at the UNC School of Medicine and the UNC Lineberger Comprehensive Cancer Center found that a rare type of stem cell is immune to radiation damage thanks to high levels of a gene called Sox9.

Contact: Mark Derewicz
University of North Carolina Health Care

Public Release: 29-Jul-2015
Nature Genetics
Basis for new treatment options for a fatal leukemia in children revealed
Acute lymphoblastic leukemia is the most common type of cancer in children. It can occur in various forms, differing not only by specific changes in the genetic material of the leukemia cells but also by their response to therapies. Now, an international team of scientists from Berlin, Düsseldorf, Hannover, Heidelberg, Kiel, and Zurich succeeded in decoding the molecular characteristics of an as yet incurable subtype of leukemia, paving the way for new therapeutic approaches.

Contact: Dr. Bodo Lange
MC Services AG

Public Release: 29-Jul-2015
Prostate 'organoid' hints at how early BPA exposure may increase cancer risk
A first-of-its kind prostate 'organoid' grown from human embryonic stem cells has enabled researchers to show that exposure to bisphenol A, a chemical in many plastics, can cause overproduction of prostate stem cells in the developing organ -- and thus may increase men's risk of prostate cancer.
National Institutes of Health, Michael Reese Research and Education Foundation

Contact: Sharon Parmet
University of Illinois at Chicago

Public Release: 29-Jul-2015
Proceedings of the National Academy of Sciences
Overcoming why a new treatment is resisted by lung cancer
A promising agent for the treatment of cancer has so far had little effect on the most common lung tumours, but new research from The University of Manchester has suggested how this resistance might be overcome.

Contact: Jamie Brown
University of Manchester

Public Release: 29-Jul-2015
Current Biology
Studies reveal details of error correction in cell division
Cell biologists led by Thomas Maresca at the University of Massachusetts Amherst, with collaborators elsewhere, report an advance in understanding the workings of an error correction mechanism that helps cells detect and correct mistakes in cell division early enough to prevent chromosome mis-segregation and aneuploidy, that is, having too many or too few chromosomes.
National Institutes of Health, March of Dimes Foundation, Charles H. Hood Foundation

Contact: Janet Lathrop
University of Massachusetts at Amherst

Public Release: 29-Jul-2015
Prostate cancer is 5 different diseases
Cancer Research UK scientists have for the first time identified that there are five distinct types of prostate cancer and found a way to distinguish between them, according to a landmark study published today in EBioMedicine.
Cancer Research UK, Prostate Cancer UK

Contact: Liz Smith
Cancer Research UK

Public Release: 29-Jul-2015
Science Translational Medicine
Red grape chemical may help prevent bowel cancer, but less is more
Resveratrol, a chemical found in red grapes, is more effective in smaller doses at preventing bowel cancer in mice than high doses, according to new research published Wednesday in the journal Science Translational Medicine.
Cancer Research UK, UK Department of Health

Contact: Stephanie McClellan
Cancer Research UK

Public Release: 28-Jul-2015
Journal of Parenteral and Enteral Nutrition
Omega-3 fatty acids may help improve treatment and quality of life in cancer patients
Adding omega-3 fatty acids to anti-tumor medications may improve treatment response and quality of life for cancer patients according to a new study by researchers at the University Hospitals of Leicester in the United Kingdom.
B. Braun Melsungen

Contact: Troy Petenbrink
American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)

Public Release: 28-Jul-2015
Journal of National Cancer Institute
Race & institutional factors play an important role in pharmacogenomic trial participation
Moffitt Cancer Center researchers have published a study in the Journal of the National Cancer Institute that analyzed the participation rate of patients in pharmacogenomic trials.
NIH/National Cancer Institute, Cancer and Leukemia Group B

Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 28-Jul-2015
International Symposium on Geroprotectors
New methods for evaluating geroprotectors to be presented at the Basel Life Science Week 2015
The fight against aging has typically been focused on attacking the symptoms of aging such as physical decay and age-related diseases, but as the study of aging advances with more longevity researchers joining the fight each year strides are being taken to fight aging at its source. The most promising method is the identification of geroprotectors, compounds which can slow or even reverse the root causes of aging and extend the human life span.

Contact: Qingsong Zhu
InSilico Medicine, Inc.

Public Release: 28-Jul-2015
Nature Genetics
Major European mouse study reveals the role of genes in disease
The role of over 300 genes has been revealed by scientists across Europe in a major initiative to understand the part they play in disease and biology. The results have now been published in the journal 'Nature Genetics'.
European Commission, Government of Canada through Genome Canada and Genome Prairie, French state funds through the 'Agence Nationale de la Recherche',

Contact: Martin Hrabe de Angelis
Helmholtz Zentrum München - German Research Center for Environmental Health

Public Release: 28-Jul-2015
Nature Communications
Pitt study: Ancient proteins involved in DNA repair could shed light on tumor development
By studying yeast used in beer- and bread-making, researchers at the University of Pittsburgh School of Medicine have uncovered the mechanism by which ancient proteins repair DNA damage and how their dysfunction could lead to the development of tumors. The findings, published online today in Nature Communications, could lead to new ways to tailor cancer therapies.
National Institutes of Health

Contact: Anita Srikameswaran
University of Pittsburgh Schools of the Health Sciences

Public Release: 28-Jul-2015
CA: A Cancer Journal for Clinicians
Cancer healthcare disparities exist in the LGBTQ community, say Moffitt researchers
Moffitt Cancer Center researchers published one of the first articles that describe the current knowledge about cancers that may disproportionately affect the LGBTQ community, and also offered suggestions for improving their healthcare.
NIH/National Cancer Institute

Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 28-Jul-2015
Nature Genetics
Ewing's sarcoma: A dangerous liaison
Researchers from Ludwig-Maximilians-Universitaet in Munich have elucidated at the molecular level how an otherwise innocuous inherited mutation that is quite common in European populations interacts with a spontaneous somatic mutation to promote the development of Ewing's sarcoma.

Contact: Luise Dirscherl
Ludwig-Maximilians-Universität München

Public Release: 28-Jul-2015
American Economic Review
Firms 'underinvest' in long-term cancer research
Pharmaceutical firms 'underinvest' in long-term research to develop new cancer-fighting drugs due to the greater time and cost required to conduct such research, according to a newly published study co-authored by MIT economists.
NIH/National Institute on Aging, National Science Foundation

Contact: Abby Abazorius
Massachusetts Institute of Technology

Public Release: 28-Jul-2015
New tool uses 'drug spillover' to match cancer patients with treatments
An article in the journal Bioinformatics from researchers at the University of Colorado Cancer Center describes a new tool that improves the ability to match drugs to disease: the Kinase Addiction Ranker predicts what genetics are truly driving the cancer in any population of cells and chooses the best 'kinase inhibitor' to silence these dangerous genetic causes of disease.
National Institutes of Health, NIH/National Cancer Institute, Cancer League of Colorado, David F. and Margaret T. Grohne Family Foundation

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 28-Jul-2015
Dog sledding offers a healthy dose of adventure for children with cancer
A common perception of the paediatric cancer patient is of a frail youth whose childhood experiences are tragically curtailed by the disease. Now, the results of a new preliminary study published in ecancermedicalscience show that children with cancer may benefit from a different kind of treatment -- a healthy dose of adventure.

Contact: Audrey Nailor

Public Release: 27-Jul-2015
Nature Genetics
New treatment options for a fatal leukemia
In industrialized countries like in Europe, acute lymphoblastic leukemia is the most common form of cancer in children. An international research consortium lead by pediatric oncologists from the universities of Zurich and Hannover has now succeeded in decoding a specific form of this leukemia, which is regarded as incurable, and in obtaining insights for new therapeutic possibilities.

Contact: Jean-Pierre Bourqin
University of Zurich

Public Release: 27-Jul-2015
Nature Genetics
Yale study identifies 'major player' in skin cancer genes
A multidisciplinary team at Yale, led by Yale Cancer Center members, has defined a subgroup of genetic mutations that are present in a significant number of melanoma skin cancer cases. Their findings shed light on an important mutation in this deadly disease, and may lead to more targeted anti-cancer therapies.
Yale SPORE in Skin Cancer, NIH/National Cancer Institute, US National Institutes of Health, Melanoma Research Alliance, Gilead Sciences, Inc., Howard Hughes Medical Institute

Contact: Ziba Kashef
Yale University

Public Release: 27-Jul-2015
Cell Reports
In lab tests, new therapy slows spread of deadly brain tumor cells
The rapid spread of a common and deadly brain tumor has been slowed down significantly in a mouse model by cutting off the way some cancer cells communicate, according to a team of researchers that includes UF Health faculty.
American Cancer Society, National Institutes of Health, Sontag Foundation, Lerner Research Institute, Florida Center for Brain Tumor Research

Contact: Doug Bennett
University of Florida

Public Release: 27-Jul-2015
Lancet Haematology
New drug for blood cancers now in five phase II clinical trials
Researchers at University of California, San Diego School of Medicine have established the safety and dosing of a new drug for treating blood cancers. The findings are published online July 27 in The Lancet Haematology.
Pfizer, European Leukemia Net

Contact: Scott LaFee
University of California - San Diego

Public Release: 27-Jul-2015
Journal of Clinical Oncology
Breast cancer survivors who experience pain during intercourse may benefit from lidocaine
Scientists at Oregon Health & Science University report that breast cancer survivors who experience pain during sexual intercourse, a common side effect of breast cancer treatment, may achieve comfort when liquid lidocaine is applied strategically to prevent pain. Their research was published online today in the Journal of Clinical Oncology.
Oregon Health & Science University Center for Women's Health Circle of Giving

Contact: Ariane Le Chevallier
Oregon Health & Science University

Public Release: 27-Jul-2015
Cancer Discovery
Clinical validation for LOXO-101 against TRK fusion cancer
Published today in Cancer Discovery, first imaging studies conducted post-treatment, confirmed that stage IV patient's tumors had substantially regressed. With four months of treatment, additional CT scans demonstrated almost complete disappearance of the largest tumors.
V Foundation Scholar Award, Loxo Oncology Research Grant, State of Colorado and University of Colorado Technology Transfer Office Bioscience Discovery Evaluation Grant Program, University of Colorado Lung Cancer SPORE

Contact: Erika Matich
University of Colorado Anschutz Medical Campus

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