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Showing releases 876-900 out of 1324.

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Public Release: 4-Feb-2015
Human Molecular Genetics
Major study links 2 new genetic variants to breast cancer
A worldwide study of the DNA of 100,000 women has discovered two new genetic variants associated with an increased risk of breast cancer. The genetic variants are specifically linked to the most common form of breast cancer, estrogen receptor positive, and provide important insights into how the disease develops.

Contact: Claire Hastings
Institute of Cancer Research

Public Release: 4-Feb-2015
Science Translational Medicine
Potential pancreatic cancer treatment could increase life expectancy
Pancreatic cancer cells are notorious for being protected by a fortress of tissue, making it difficult to deliver drugs to either shrink the tumor or stop its growth. Now researchers at the University of North Carolina at Chapel Hill have developed a device that could change all that: By using electric fields, the device can drive chemotherapy drugs directly into tumor tissue, preventing their growth and in some cases, shrinking them.
The University Cancer Research Fund, NIH/Pioneer Award, Synecor LLC, and others

Contact: Thania Benios
University of North Carolina at Chapel Hill

Public Release: 4-Feb-2015
CA: A Cancer Journal for Clinicians
Lung cancer now leading cause of cancer death in females in developed countries
A new analysis led by researchers at the American Cancer Society in collaboration with the International Agency for Research on Cancer finds lung cancer has surpassed breast cancer as the leading cause of cancer death in females in developed countries.
American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 3-Feb-2015
Journal of Clinical Oncology
Smoking linked to higher risk of death among colorectal cancer survivors
Colorectal cancer survivors who smoke cigarettes were at more than twice the risk of death than non-smoking survivors, according to a new American Cancer Society study
American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 3-Feb-2015
British Journal of Cancer
One in 2 people in the UK will get cancer
One in two people will develop cancer at some point in their lives, according to the most accurate forecast to date from Cancer Research UK, and published in the British Journal of Cancer.
Cancer Research UK

Contact: Greg Jones
Cancer Research UK

Public Release: 3-Feb-2015
Genome Biology
Culture shock -- Are lab-grown cells a faithful model for human disease?
Cell cultures used in research may not act as a faithful mimic of real tissue, according to research published in Genome Biology. Laboratory-grown cells experience altered cell states within three days as they adapt to their new environment. Studies of disease, including cancer, rely on cell cultures that have often been grown for decades. The findings could affect the interpretation of past studies and provide important clues for improving cell cultures in the future.

Contact: Joel Winston
BioMed Central

Public Release: 3-Feb-2015
Journal of Immunology
A few cells could prevent bone marrow transplant infections
Researchers find clues for reducing infections after bone marrow transplantation for leukemia and lymphoma.

Contact: Edyta Zielinska
Thomas Jefferson University

Public Release: 3-Feb-2015
MicroRNAs can limit cancer spread
In cancer patients with limited spread, certain microRNAs suppress tumor cells' ability to adhere to other cell types, invade tissues and migrate to distant sites, the hallmarks of metastasis. This could predict how aggressively a tumor can spread and guide treatment.
Virginia and D.K. Ludwig Fund for Cancer Research, Lung Cancer Foundation, Prostate Cancer Foundation, Foglia Family

Contact: John Easton
University of Chicago Medical Center

Public Release: 3-Feb-2015
Sparing hope for the future: Preserving fertility in cancer patients
While families around the world delay childbearing to later in life, cancer diagnoses are affecting people ever earlier in life. When these lifestyle trends collide, we see an increasing number of young women rendered infertile by cancer or cancer treatments. What can be done about it? What do doctors need to know? And does a cancer diagnosis mean that a patient can never have children?

Contact: Katie Foxall

Public Release: 3-Feb-2015
Stem Cell Reports
Glioblastoma: Study ties 3 genes to radiation resistance in recurrent tumors
A new study identifies three genes that together enable a lethal form of brain cancer to recur and progress after radiation therapy. The findings could lead to new therapies for brain tumors that target cancer stem cells.
American Cancer Society, National Institutes of Health, Danish Cancer Society, Danish National Research Foundation

Contact: Darrell E. Ward
Ohio State University Wexner Medical Center

Public Release: 3-Feb-2015
Serendipity leads to discovery of adult cancer genes in young-adult Ewing Sarcoma
A University of Colorado Cancer Center study published in the journal PLoS One finds alterations in expression of genes PIK3R3 and PTEN, more commonly observed in adult tumors, in the rare, young-adult bone cancer Ewing Sarcoma, potentially offering ways to improve therapy.

Contact: Garth Sundem
University of Colorado Denver

Public Release: 3-Feb-2015
Dartmouth researchers reprogram tumor's cells to attack itself
Inserting a specific strain of bacteria into the microenvironment of aggressive ovarian cancer transforms the behavior of tumor cells from suppression to immunostimulation, Dartmouth researchers have found. The findings demonstrate a new approach in immunotherapy that can be applied in a variety of cancer types.
National Institutes of Health, NIH/National Institute of General Medical Sciences

Contact: Kirk Cassels
The Geisel School of Medicine at Dartmouth

Public Release: 3-Feb-2015
Nature Genetics
Study sheds new light on aggressive cancer in children
A new study involving researchers at The University of Nottingham has revealed how children with an aggressive cancer predisposition syndrome experience a never before seen flood of mutations in their disease in just six months.
BRAINchild Canada, Canadian Institutes of Health Research, Wellcome Trust Sanger Institute, SickKids Foundation

Contact: Emma Rayner
University of Nottingham

Public Release: 3-Feb-2015
Heart Failure Winter Research Meeting
New molecule protects heart from toxic breast cancer drugs
A new molecule has been found that protects the heart from toxic breast cancer drugs and also kills the cancerous tumor. The research from Italy addresses the burgeoning problem of heart disease in cancer survivors and is announced by the European Society of Cardiology today on World Cancer Day.

Contact: Céline Colas
European Society of Cardiology

Public Release: 2-Feb-2015
Nature Communications
Epigenetic signatures that differentiate triple-negative breast cancers
Australian researchers have identified epigenetic 'signatures' that could help clinicians tell the difference between highly aggressive and more benign forms of triple-negative breast cancer.
National Breast Cancer Foundation

Contact: Alison Heather
Garvan Institute of Medical Research

Public Release: 2-Feb-2015
New pathway for stalling BRCA tumor growth revealed
Inhibiting the action of a particular enzyme dramatically slows the growth of tumor cells tied to BRCA1 and BRCA2 genetic mutations which, in turn, are closely tied to breast and ovarian cancers, according to researchers at NYU Langone Medical Center.

Contact: David March
NYU Langone Medical Center / New York University School of Medicine

Public Release: 2-Feb-2015
Cancer Prevention Research
Metformin may lower lung cancer risk in diabetic nonsmokers
Among nonsmokers who had diabetes, those who took the diabetes drug metformin had a decrease in lung cancer risk.
National Institutes of Health

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 2-Feb-2015
Journal of Clinical Investigation
Activated immune cells indicate a favorable prognosis in colorectal cancer
When cytotoxic T cells are activated, they produce TNF alpha that helps mediate immune responses. Scientists from Heidelberg and Dresden have now linked rising levels of TNF alpha in tumor tissue to increasing numbers of activated killer cells that specifically recognize the tumor and are capable of fighting it. High levels of TNF alpha in a tumor prove to be an independent prognostic indicator for a favorable course of the disease.

Contact: Sibylle Kohlstädt
German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)

Public Release: 2-Feb-2015
Journal of Clinical Oncology
Which breast cancer patients need lymph nodes removed? Ultrasound narrows it down, study finds
Which breast cancer patients need to have underarm lymph nodes removed? Mayo Clinic-led research is narrowing it down. A new study finds that not all women with lymph node-positive breast cancer treated with chemotherapy before surgery need to have all of their underarm nodes taken out. Ultrasound is a useful tool for judging before breast cancer surgery whether chemotherapy eliminated cancer from the underarm lymph nodes, the researchers found. The findings are published in the Journal of Clinical Oncology.

Contact: Sharon Theimer
Mayo Clinic

Public Release: 2-Feb-2015
Journal of Thoracic Disease
Whose numbers determine cost-effectiveness of targeted anti-cancer therapies?
'Increasingly physicians are being presented with health economic analyses in mainstream medical journals as a means of potentially influencing their prescribing. However, it is only when you understand the multiple assumptions behind these calculations that you can see that they are by no means absolute truths,' says D. Ross Camidge, M.D., Ph.D., investigator at the University of Colorado Cancer Center.

Contact: Garth Sundem
University of Colorado Denver

Public Release: 2-Feb-2015
British Journal of Surgery
Surgical innovations brought to you by the British Journal of Surgery
Special issue of the British Journal of Surgery highlights surgical innovations.

Contact: Dawn Peters

Public Release: 2-Feb-2015
Cell Cycle
Dartmouth researchers discover new mechanism of acquired resistance to breast cancer drugs
In the search for new approaches to treat ERBB2 -- also known as HER2 -- positive breast cancers that have become drug-resistant, Dartmouth investigator Manabu Kurokawa, Ph.D., led a team in discovery of a novel cancer resistance mechanism.
National Institutes of Health

Contact: Kirk Cassels
The Geisel School of Medicine at Dartmouth

Public Release: 2-Feb-2015
Moffitt researchers discover biological markers associated with high-risk pancreatic lesions
Pancreatic cancer affects approximately 46,000 people each year in the United States and ranks fourth among the leading causes of cancer-related deaths. Only about 6 percent of individuals with pancreatic cancer will live five years after their diagnosis. One reason for this high mortality rate is the lack of effective tools to detect pancreatic cancer early enough to allow its surgical removal. Moffitt Cancer Center researchers are now one step closer to devising an approach to detect pancreatic cancer earlier.
American Chemical Society, NIH/National Cancer Institute

Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 2-Feb-2015
FASEB Journal
New method shrinks metastatic ovarian cancer and reduces chemotherapy dose
New research published in the February 2015 issue of The FASEB Journal may eventually help improve the five-year survival rate of ovarian cancer patients by describing a new way of shrinking ovarian cancer tumors while also simultaneously improving drug delivery.

Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Public Release: 2-Feb-2015
Nature Methods
Scientists open new chapter in cell biology and medicine
An entirely new approach for the mechanical characterization of cells, developed by scientists of the Technische Universität Dresden, has the potential to revolutionize the diagnosis of a wide range of diseases.

Contact: Dr. Jochen Guck
Technische Universität Dresden

Showing releases 876-900 out of 1324.

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