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Public Release: 12-Oct-2015
Cancer Cell
First comprehensive profile of non-protein-coding RNAs in human cancers
70 percent of the genome is made into non-coding RNA, but most studies of genomic alterations in cancer have focused on the miniscule portion of the human genome that encodes protein. An international team has mined these RNA sequences more fully to identify non-protein-coding segments whose expression is linked to 13 different types of cancer.
Basser Center for BRCA, NIH/National Cancer Institute, Ovarian Cancer Research Fund, Breast Cancer Alliance, Marsha Rivkin Center for Ovarian Cancer Research, China Scholarship Council

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 12-Oct-2015
Cancer Cell
Turncoat protein regulates sensitivity of breast cancer cells to drug
A surprising, paradoxical relationship between a tumor suppressor molecule and an oncogene may be the key to explaining and working around how breast cancer tumor cells become desensitized to a common cancer drug.
NIH/National Cancer Institute, Caring for Carcinoid Foundation-AACR Grant Care for Carcinoid Foundation, University of Pennsylvania, and others

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

Public Release: 12-Oct-2015
Nature Medicine
Scientists uncover 4 different types of bowel cancer
Bowel cancer can be divided up into four distinct diseases, each with its own set of biological characteristics, a major new study reports. The research could allow doctors to treat each type of bowel cancer differently - and drive the design of distinct sets of targeted drugs for each type.
Institute of Cancer Research London, NIHR Biomedical Research Centre at the Royal Marsden, Institute of Cancer Research

Contact: Claire Hastings
Institute of Cancer Research

Public Release: 11-Oct-2015
Lifestyle factors driving more bowel cancer deaths in European men, trends study shows
A new study into rates of bowel (colorectal) cancer in Europe reveals a significant reduction in deaths from the disease in women, but more deaths in men.

Contact: Jane Gardner
University of Melbourne

Public Release: 9-Oct-2015
Science Translational Medicine
Antioxidants cause malignant melanoma to metastasize faster
Fresh research at Sahlgrenska Academy has found that antioxidants can double the rate of melanoma metastasis in mice. The results reinforce previous findings that antioxidants hasten the progression of lung cancer. According to Professor Martin Bergö, people with cancer or an elevated risk of developing the disease should avoid nutritional supplements that contain antioxidants.

Contact: Martin Bergö
University of Gothenburg

Public Release: 9-Oct-2015
American Society of Human Genetics 2015 Annual Meeting
Researchers use gut bacteria composition to genetically classify colorectal tumors
By analyzing the types of gut bacteria present around colorectal tumors, researchers have found a way to predict key genetic mutations in the tumors themselves, a method that could eventually inform the development of colorectal cancer diagnostics and therapeutics. Their findings were presented at the American Society of Human Genetics 2015 Annual Meeting in Baltimore.

Contact: Nalini Padmanabhan
American Society of Human Genetics

Public Release: 9-Oct-2015
American Journal of Surgery
Adoption of streamlined breast cancer treatment has stagnated, study finds
It was hoped that the development of accelerated partial breast irradiation would increase the number of early-stage breast cancer patients getting radiation treatment. A new study, however, has found that adoption of the technique has stagnated -- and many women still aren't getting the radiation treatment that could save their lives.

Contact: Josh Barney
University of Virginia Health System

Public Release: 9-Oct-2015
Nature Communications
Scientists pave way for diamonds to trace early cancers
Physicists from the University of Sydney, Australia, have devised a way to use diamonds to identify cancerous tumours before they become life threatening. Their findings, published today in Nature Communications, reveal how a nanoscale, synthetic version of the precious gem can light up early-stage cancers in non-toxic, non-invasive Magnetic Resonance Imaging (MRI) scans.
Australian Research Council Centre of Excellence Scheme

Contact: Vivienne Reiner
University of Sydney

Public Release: 9-Oct-2015
PLOS Computational Biology
Moffitt researchers develop novel theoretical approach to reduce antibiotic resistance
Moffitt Cancer Center researchers have developed a novel mathematical method inspired by Darwinian evolution to use current antibiotics to eliminate or reduce the development of antibiotic-resistant bacteria.
Engineering and Physical Sciences Research Council, National Institutes of Health Loan Repayment Program, National Cancer Institute Integrative Cancer Biology Program, National Cancer Institute Physical Sciences in Oncology Centers

Contact: Kimberly Polacek
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 9-Oct-2015
Novel compound turns off mutant cancer gene in animals with leukemia
A compound discovered and developed by a team of Georgetown Lombardi Comprehensive Cancer Center researchers that halts cancer in animals with Ewing sarcoma and prostate cancer appears to work against some forms of leukemia, too. That finding and the team's latest work was published in Oncotarget.
Children's Cancer Foundation, St. Baldrick's Foundation, Go4theGoal, Burroughs Wellcome Fund Clinical Scientist Award in Translational Research, Austrian Science Fund, Children´s Cancer Research Institute, NIH

Contact: Karen Teber
Georgetown University Medical Center

Public Release: 9-Oct-2015
IDWeek 2015
UV light robots cut c. diff transmissions by 25 percent on cancer patient floors
New research from Penn Medicine infection control specialists found that ultraviolet robots helped reduce the rates transmission of the common bacterial infection known as Clostridium difficile among cancer inpatients -- mostly blood cancer patients, a group more vulnerable to hospital-acquired infections -- by 25 percent. The interventions also saved about $150,000 in annual direct medical costs.

Contact: Steve Graff
University of Pennsylvania School of Medicine

Public Release: 9-Oct-2015
3-D image of cancer protein aids quest for new treatments
Scientists at the Walter and Eliza Hall Institute have created the first three-dimensional image of a key protein known to be involved in the development of blood and other cancers. The discovery showed the protein, called Trib1, plays a vital role in controlling how and when other proteins are degraded, which is essential for managing protein levels in the cell. The finding could be used to develop new drugs to treat cancers such as leukaemia, caused by malfunctioning of the Trib1 protein.
Health Research Council of New Zealand, New Zealand government, Australian Cancer Research Foundation, Australian National Health and Medical Research Council

Contact: Liz Williams
Walter and Eliza Hall Institute

Public Release: 8-Oct-2015
Researchers unlock secrets of troublesome Tribble protein
Scientists from New Zealand and Australia have created the first three-dimensional image of a key protein involved in the development of blood and other cancers. The researchers have shown how the protein, called Trib1, plays a vital role in controlling how and when other proteins are degraded, which is essential for balancing protein levels in the cell.
Health Research Council of New Zealand, New Zealand government, Australian Cancer Research Foundation, Australian National Health and Medical Research Council, Victorian Government Operational Infrastructure Support Program

Contact: Peter Mace
University of Otago

Public Release: 8-Oct-2015
Nature Cell Biology
Researchers discover new information on the spread of cancer
A new study from the University of Turku, Finland, shows that intracellular receptor signalling sustains cancer cells that have detached from the surrounding tissue. When the signalling is prevented, the cells cannot spread to other parts of the body. This significant research result influences how cancer research is directed in the future.
University of Turku, Turku Centre for Biotechnology

Contact: Johanna Ivaska
Academy of Finland

Public Release: 8-Oct-2015
Molecular Cell
A convergence of deadly signals
A team of Ludwig Cancer Research scientists has mapped out how a mutant version of the epidermal growth factor receptor (EGFR) known as EGFRvIII specifically drives critical processes that alter the reading of the genome to fuel the growth of the brain cancer glioblastoma multiforme and -- most important -- how each process is linked to the other.
Ludwig Cancer Research, NIH/National Institute for Neurological Diseases and Stroke, National Brain Tumor Society, Ziering Family Foundation, Ben and Catherine Ivy Foundation, UCSD Core Facility Stimulus Funding, and others

Contact: Rachel Steinhardt
Ludwig Institute for Cancer Research

Public Release: 8-Oct-2015
JAMA Oncology
Study examines cancer-care outcomes among US hospitals
Efforts to rank hospitals by long-term survival rates have been hindered by the readily available administrative data derived from Medicare claims, which lacks information about cancer stage. A new MSK study published in JAMA Oncology finds that risk-adjusted Medicare claims data -- without information about the cancer stage of individual patients -- may be sufficient to calculate the long-term survival rates at hospitals providing cancer care in the US.

Contact: Jeanne D'Agostino
Memorial Sloan Kettering Cancer Center

Public Release: 8-Oct-2015
Identified an 'alarm clock' of a leukemia-causing oncogene
Researchers at the Bellvitge Biomedical Research Institute, led by Manel Esteller have shown that mutations in DNMT3A gene cause MEIS1 activacion, triggering leukemia. The study results are published in the journal Oncogene.
European Community's Seventh Framework Program, Cellex Foundation, MINECO Project

Contact: Arantxa Mena
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 8-Oct-2015
JAMA Oncology
Examining contemporary occupational carcinogen exposure, bladder cancer
Despite manufacturing and legislative changes to improve workplace hygiene, the risk of occupational bladder cancer appears to be on the rise in some industries, although the profile of at-risk occupations has changed over time, according to an article published online by JAMA Oncology.

Contact: James W.F. Catto, M.B.Ch.B., Ph.D., F.R.C.S.
The JAMA Network Journals

Public Release: 8-Oct-2015
'This enormous burden': Controlling cervical cancer in Latin America
Cervical cancer is an 'enormous burden' for Latin-American society, and the third leading cause of cancer deaths among women in the region, say Dr. María Correnti and Dr. María Eugenia Cavazza of the Central University of Venezuela, Caracas, Venezuela, guest editors of the latest special issue from ecancermedicalscience. This edition collects four new research articles on the topic of cervical cancer prevention in Latin America.

Contact: Audrey Nailor

Public Release: 8-Oct-2015
High dose chemo & stem cell transplantation results in long-term survival for amyloid patients
Patients with Light-chain amyloidosis who are treated with high-dose chemotherapy and autologous (one's own) stem cell transplantation (HDM/SCT) have the greatest success for long-term survival.

Contact: Gina DiGravio
Boston University Medical Center

Public Release: 8-Oct-2015
Cell Reports
Researchers create 'leukemia in a dish' to better study it
Scientists engineered stem cells to better understand the mechanisms behind a form of leukemia caused by changes in a key gene, according to a study led by Mount Sinai researchers and published online today in the journal Cell Reports.
New York Stem Cell Science, National Institutes of Health, Associazione Italia Per La Ricerca Sul Cancro, Fondazione Telethon

Contact: David Slotnick
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 8-Oct-2015
American Journal of Public Health
Older tobacco users pay more for health insurance under Affordable Care Act
A new study finds tobacco users would pay more for a health insurance plan from the Affordable Care Act exchanges than non-tobacco users in nearly every county of the 37 states that used to sell their plans in 2015.
American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 8-Oct-2015
Protein research uncovers potential new diagnosis and therapy for breast cancer
Scientists at the University of York, using clinical specimens from charity Breast Cancer Now's Tissue Bank, have conducted new research into a specific sodium channel that indicates the presence of cancer cells and affects tumour growth rates.
Medical Research Council

Contact: Saskia Angenent
University of York

Public Release: 8-Oct-2015
Scientific Reports
A multilaminar model explains the structure of chromosomal aberrations in cancer cells
The organization of DNA packaged in chromosomes during cell division has been very difficult to study experimentally. Researchers from the Universitat Autònoma de Barcelona have found that the structure of translocations in cancer cells shows that chromosomes are formed by thin plates of chromatin.

Contact: Joan-Ramon Daban
Universitat Autonoma de Barcelona

Public Release: 8-Oct-2015
Future Oncology
Future Oncology 10th anniversary SFI celebrates the past, present and future in cancer
Future Oncology is celebrating its tenth anniversary by publishing a Special Focus issue documenting the past, present and future of several cancers.

Contact: Leela Ripton
Future Science Group

Showing releases 876-900 out of 1300.

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