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Public Release: 19-Jun-2014
Computer-designed protein triggers self-destruction of Epstein-Barr-infected cancer cells
A protein molecule, BINDI, has been built to trigger self-destruction of cancer cells infected with the Epstein-Barr virus.
National Institutes of Health, Washington Life Sciences Discovery Fund, US Defense Threat Reduction Agency, and others

Contact: Elizabeth Hunter
University of Washington Health Sciences/UW Medicine

Public Release: 19-Jun-2014
Journal of the National Cancer Institute
A shorter time to the first cigarette of the day is associated with risk of lung cancer
Standard markers of nicotine dependency include cigarettes smoked per day, duration of smoking, and cumulative exposure (pack years), but another marker of addiction, time to first cigarette of the day, may also be associated with the risk of getting lung cancer in both heavy and light smokers, according to a study published June 19 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
Oxford University Press USA

Public Release: 19-Jun-2014
Feel-good hormones could cause UV addiction
Sun lovers eagerly flock to the beach every summer, despite widespread awareness of the risk of skin cancer. A new study reveals that chronic exposure to UV radiation causes the release of feel-good hormones called endorphins, which act through the same pathway as heroin, leading to physical dependence, tolerance, and addiction-like behavior in rodents. The findings could explain why people have an instinctive desire to be in the sun, despite its known health risks.

Contact: Mary Beth O'Leary
Cell Press

Public Release: 19-Jun-2014
UV-induced beta-endorphin production causes addiction-like symptoms in mice
A new study from Massachusetts General Hospital investigators adds important support to the theory that ultraviolet light can actually be addictive, finding that chronic UV exposure raises circulating levels of beta-endorphin in mice and that UV-habituated mice exhibit withdrawal symptoms if beta-endorphin activity is blocked.
National Institutes of Health, Melanoma Research Alliance, US-Israel Binational Science Foundation, Adelson Medical Research Foundation

Contact: Terri Ogan
Massachusetts General Hospital

Public Release: 19-Jun-2014
PLOS Genetics
Strict diet suspends development, doubles lifespan of worms
Researchers at Duke University found that taking food away from C. elegans triggers a state of arrested development: while the organism continues to wriggle about, foraging for food, its cells and organs are suspended in an ageless, quiescent state. When food becomes plentiful again, the worm develops as planned, but can live twice as long as normal.
American Cancer Society, National Institutes of Health

Contact: Karl Bates
Duke University

Public Release: 19-Jun-2014
Cleveland Clinic researchers discover protein that inhibits tumor growth
A previously unknown variant of an extensively studied protein has been found to inhibit the growth of tumors and slow the development of new blood vessels necessary for cancers to metastasize, according to Cleveland Clinic research published today in Cell.
National Institutes of Health

Contact: Laura Ambro
Cleveland Clinic

Public Release: 19-Jun-2014
Stanford bioengineers invent a way to speed up drug discovery
The 500 or so kinase proteins are particularly important to drug discovery. Kinases are messenger/signaling proteins that regulate and orchestrate the actions of other proteins. Proper kinase activity maintains health. Irregular activity is linked to cancer and other diseases. Many drugs seek to either boost or suppress kinase activity. Stanford bioengineers have invented a way to observe and report on the behavior of these signaling proteins as they work inside living cells.

Contact: Tom Abate
Stanford School of Engineering

Public Release: 18-Jun-2014
New England Journal of Medicine
New report offers a primer for doctors' use of clinical genome and exome sequencing
Sooner than almost anyone expected, a new, genome-based technology for demystifying undiagnosed illnesses -- particularly rare childhood diseases -- is moving from research laboratories into general medical practice. Now, two leading scientists, writing in the June 19, 2014, issue of the New England Journal of Medicine, have sketched out what doctors need to know in order to use the new technology effectively.
National Institutes of Health

Contact: Raymond MacDougall
NIH/National Human Genome Research Institute

Public Release: 18-Jun-2014
JAMA Surgery
Racial disparities in sentinel lymph node biopsy in women with breast cancer
The use of sentinel lymph node biopsy to stage early breast cancer increased in both black and white women from 2002 to 2007, but the rates remained lower in black than white patients, a disparity that contributed to disparities in the risk for lymphedema (arm swelling common after breast cancer treatment because of damage to the lymphatic system).

Contact: Julie A. Penne
The JAMA Network Journals

Public Release: 18-Jun-2014
British Journal of Obstetrics and Gynaecology
No link found between soy food and endometrial cancer risk, say researchers
Researchers have found no evidence of a protective association between soy food and endometrial cancer risk, says a new study published June 18 in BJOG: An International Journal of Obstetrics and Gynaecology.

Contact: Nicole Weingartner

Public Release: 18-Jun-2014
Cancer Immunology Research
Vaccine 'reprograms' pancreatic cancers to respond to immunotherapy
Researchers at the Johns Hopkins Kimmel Cancer Center have developed and tested a vaccine that triggered the growth of immune cell nodules within pancreatic tumors, essentially reprogramming these intractable cancers and potentially making them vulnerable to immune-based therapies.
NIH/National Cancer Institute

Contact: Michelle Potter
Johns Hopkins Medicine

Public Release: 18-Jun-2014
Tobacco Control
Study shows cost-effectiveness of smoking cessation counseling during hospitalization
In a recent study published in Tobacco Control, researchers at the University of Ottawa Heart Institute have demonstrated the cost-effectiveness of the Ottawa Model for Smoking Cessation, an intervention that includes in-hospital counseling, pharmacotherapy and post-hospital follow-up, compared to usual care among smokers hospitalized with acute myocardial infarction, unstable angina, heart failure, and chronic obstructive pulmonary disease.

Contact: Vincent Lamontagne
University of Ottawa Heart Institute

Public Release: 18-Jun-2014
American Society of Clinical Oncology 2014 Conference
Breathalyzer test may detect deadliest cancer
Lung cancer causes more deaths in the US than the next three most common cancers combined. Now a new breathalyzer test, embedded with a 'NaNose' nanotech chip to literally 'sniff out' cancer tumors, has been developed by a team of international researchers including Prof. Nir Peled of Tel Aviv University's Sackler Faculty of Medicine. It may turn the tide by both accurately detecting lung cancer and identifying its stage of progression.

Contact: George Hunka
American Friends of Tel Aviv University

Public Release: 18-Jun-2014
PLOS Genetics
Following direction: How neurons can tell top from bottom and front from back
The question of how neurons and their axons establish spatial polarity and direction in tissues and organs is a fundamental question of any organism or biological system. Our cells and axons precisely orient themselves in response to external cues, but what are the core pathways and how are they integrated?
Canadian Institutes of Health Research

Contact: Polly Thompson
Lunenfeld-Tanenbaum Research Institute

Public Release: 18-Jun-2014
Journal of Clinical Oncology
Telephone call is effective support when breast cancer treatment includes weight loss
A series of simple telephone calls can make a profound difference in helping women to meet their treatment goals for breast cancer, according to a randomized trial of women who are also obese.

Contact: Polly Thompson
Lunenfeld-Tanenbaum Research Institute

Public Release: 18-Jun-2014
Scripps Research Institute scientists reveal molecular 'yin-yang' of blood vessel growth
Biologists at The Scripps Research Institute have discovered a crucial process that regulates the development of blood vessels. The finding could lead to new treatments for disorders involving abnormal blood vessel growth, including common disorders such as diabetic retinopathy and cancer.
National Institutes of Health, National Foundation for Cancer Research

Contact: Madeline McCurry-Schmidt
Scripps Research Institute

Public Release: 18-Jun-2014
False negative results found in prognostic testing for breast cancer
Researchers retested tumor samples from a large group of women and found that 22 out of 530 women had their tumor type incorrectly classified in local labs, which precluded them from effective treatment options.
Roche-Genentech, Inc.

Contact: Donna Dubuc
The Geisel School of Medicine at Dartmouth

Public Release: 17-Jun-2014
INFORMS Advances in Decision Analysis Conference
Breast cancer diagnosis, mammography improved by considering patient risk: INFORMS paper
A new approach to examining mammograms that takes into account a woman's health risk profile would reduce the number of cancer instances missed and also cut the number of false positives, according to a paper being presented at a conference of the Institute for Operations Research and the Management Sciences (INFORMS).

Contact: Barry List
Institute for Operations Research and the Management Sciences

Public Release: 17-Jun-2014
Gut bacteria predict survival after stem cell transplant, study shows
New research published online today in Blood, the Journal of the American Society of Hematology, suggests that the diversity of bacteria in the gastrointestinal tract of patients receiving stem cell transplants may be an important predictor of their post-transplant survival.

Contact: Amanda Szabo
American Society of Hematology

Public Release: 17-Jun-2014
Genetic pathway can slow spread of ovarian cancer
University of Adelaide research into the origins of ovarian cancer has led to the discovery of a genetic pathway that could slow the spread of the cancer.

Contact: Associate Professor Frank Grützner, University of Adelaide
University of Adelaide

Public Release: 17-Jun-2014
Breast Cancer Research and Treatment
Potential cholesterol lowering drug has breast cancer fighting capabilities
Researchers at the University of Missouri have proven that a compound initially developed as a cholesterol-fighting molecule not only halts the progression of breast cancer, but also can kill the cancerous cells.
Department of Defense Breast Cancer Program

Contact: Jeff Sossamon
University of Missouri-Columbia

Public Release: 17-Jun-2014
American Journal of Roentgenology
3D breast imaging could revolutionize cancer screening
The largest report to date shows that 3D DBT (versus 2D DM) increases the detection rate for cancer overall by 28.6 percent and by 43.8 percent in detecting invasive cancers.

Contact: Lissa D. Hurwitz
American Roentgen Ray Society

Public Release: 17-Jun-2014
Tobacco Control
Want to know about vaping? Turn on the TV or go online
UIC study finds social networking is a critical component of e-cig marketing.

Contact: Sherri McGinnis Gonzalez
University of Illinois at Chicago

Public Release: 17-Jun-2014
$2.4 million NIH center grant to develop a cleaner, healthier environment in Detroit
With over $2.4 million in new federal funding, Wayne State University researchers, regional collaborators at Henry Ford Health System, the University of Michigan and Michigan State University, and community partners will study how exposures to stressors that are prevalent in the urban industrialized environment -- both chemical and non-chemical -- impact human health in Detroit and beyond.
NIH/National Institute of Environmental Health Sciences

Contact: Julie O'Connor
Wayne State University - Office of the Vice President for Research

Public Release: 17-Jun-2014
Current Oncology
Barriers to obtaining gene expression profiling test heightened perceived value
Barriers to obtaining gene expression profiling tests heightened their perceived importance among patients with early breast cancer who were deciding whether to have chemotherapy, a new study says.
Cancer Care Ontario, Ontario Institute for Cancer Research, Canadian Centre for Applie

Contact: Leslie Shepherd
St. Michael's Hospital

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