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Showing releases 901-925 out of 1242.

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Public Release: 16-Apr-2014
Genome Research
Research uncovers DNA looping damage tied to HPV cancer
Certain strains of human papillomavirus (HPV) are known to cause about five percent of all cancer cases, yet all the mechanisms aren't completely understood. Now, researchers, led by The Ohio State University's David Symer, M.D., Ph.D., have leveraged Ohio Supercomputer Center resources and whole-genome sequencing to identify a new way that HPV might spark cancer development -- by disrupting the human DNA sequence with repeating loops when HPV is inserted into host-cell DNA as it replicates.
NIH/National Cancer Institute Center for Cancer Research

Contact: Mr. Jamie Abel
Ohio Supercomputer Center

Public Release: 16-Apr-2014
Science Translational Medicine
Celldex's Phase 1 study of CDX-1401 published in Science Translational Medicine
Celldex Therapeutics Inc. announced today that final data from its Phase 1 study of CDX-1401 in solid tumors, including long-term patient follow-up, have been published in Science Translational Medicine. The data demonstrate robust antibody and T cell responses and evidence of clinical benefit in patients with very advanced cancers and suggest that CDX-1401 may predispose patients to better outcomes on subsequent therapy with checkpoint inhibitors.

Contact: Sarah Cavanaugh
Celldex Therapeutics

Public Release: 16-Apr-2014
Journal of Adolescent Health
Masculine boys, feminine girls more likely to engage in cancer risk behaviors
The most 'feminine' girls and 'masculine' boys -- are more likely than their peers to engage in behaviors that pose cancer risks, according to a new study led by Harvard School of Public Health researchers. The most feminine teenage girls use tanning beds more frequently and are more likely to be physically inactive, while the most masculine teenage boys are more likely to chew tobacco and smoke cigars compared with gender-nonconforming peers.
National Institutes of Health, Maternal and Child Health Bureau, Health Resources and Services Administration, Leadership Education in Adolescent Health Project

Contact: Marge Dwyer
Harvard School of Public Health

Public Release: 16-Apr-2014
Cancer Causes & Control
Body Mass Index associated with breast cancer, regardless of body shape
A study of predominantly white women finds a larger waist circumference is associated with higher risk of postmenopausal breast cancer, but not beyond its contribution to BMI.
American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 15-Apr-2014
Cancer Research
Blood test spots recurrent breast cancers and monitors response to treatment
Johns Hopkins Kimmel Cancer Center investigators report they have designed a blood test that accurately detects the presence of advanced breast cancer and also holds promise for precisely monitoring response to cancer treatment.
Avon, NIH/National Cancer Institute

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 15-Apr-2014
Journal of the American Chemical Society
Targeting cancer with a triple threat
MIT chemists design nanoparticles that can deliver three cancer drugs at a time.
Royal Society of Chemistry, Ovarian Cancer Teal Innovator Award, National Institutes of Health, Natural Sciences and Engineering Research Council of Canad, Koch Institute Support Grant from the National Cancer Institute

Contact: Sarah McDonnell
Massachusetts Institute of Technology

Public Release: 15-Apr-2014
European Journal of Cancer
Can refined categorization improve prediction of patient survival in RECIST 1.1?
In a recent analysis by the RECIST Working Group published in the European Journal of Cancer, EORTC researchers had explored whether a more refined categorization of tumor response or various aspects of progression could improve prediction of overall survival in the RECIST database. They found that modeling target lesion tumor growth did not improve the prediction of overall survival above and beyond that of the other components of progression.
European Organisation for Research and Treatment Charitable Trust

Contact: John Bean
European Organisation for Research and Treatment of Cancer

Public Release: 15-Apr-2014
Cancer Research
Unexpected protein partnership has implications for cancer treatment
Scientists have identified two unlikely partners, in a type of immune cell called a macrophage, that work together, in response to cancer drugs, to increase inflammation in a way that may alter tumor growth. Researchers from the National Institutes of Health published the study in the journal Cancer Research.
NIH/National Institute of Environmental Health Sciences

Contact: Joe Balintfy
NIH/National Institute of Environmental Health Sciences

Public Release: 15-Apr-2014
Journal of Biomedical Nanotechnology
UT Arlington physicist creates new nanoparticle for cancer therapy
In a newly published paper, a University of Texas at Arlington physicist describes a newly created complex that may make photodynamic therapy for cancer treatment more efficient and cost effective and effective against deep tissue cancers.
Department of Defense Congressionally Directed Medical Research Programs

Contact: Traci Peterson
University of Texas at Arlington

Public Release: 14-Apr-2014
Chemotherapy before or after surgery for high-risk bladder cancer improves survival, but is not routinely administered
Contrary to treatment guidelines for high-risk bladder cancer, chemotherapy before or after surgery is not commonly used in routine clinical practice.

Contact: Evelyn Martinez

Public Release: 14-Apr-2014
Cancer Cell
'MicroRNA' could be key target for bowel cancer treatment
A tiny genetic molecule known as a microRNA plays a central role in bowel cancer and could be key to developing new treatments for the disease, a new study concludes.

Contact: Graham Shaw
Institute of Cancer Research

Public Release: 14-Apr-2014
Cancer Cell
Study identifies a likely key driver of colorectal cancer development and progression
A new study identifies a molecule that is a probable driving force in colorectal cancer. The molecule could be an important target for colorectal cancer treatment and a valuable biomarker of tumor progression.
National Institutes of Health, Crohn's and Colitis Foundation of America

Contact: Darrell E. Ward
Ohio State University Wexner Medical Center

Public Release: 14-Apr-2014
Gastrointestinal Endoscopy
Website information on colon cancer too complex, fails to address key concerns
Popular web information on colorectal cancer is too difficult for most lay people to read and doesn't address the appropriate risks to and concerns of patients, a study by UT Southwestern gastroenterologists suggests.

Contact: Russell Rian
UT Southwestern Medical Center

Public Release: 14-Apr-2014
Journal of Clinical Sleep Medicine
Study links severe sleep apnea to increased risk of stroke, cancer and death
A new study shows that moderate to severe obstructive sleep apnea is independently associated with an increased risk of stroke, cancer and death.
Australian National Health and Medical Research Council

Contact: Lynn Celmer
American Academy of Sleep Medicine

Public Release: 14-Apr-2014
Nature Communications
Nano shake-up
Researchers in the University of Delaware Department of Chemical and Biomolecular Engineering have shown that routine procedures in handling and processing can have a significant influence on the size, shape and delivery of drug nano carriers.
National Institutes of Health

Contact: Andrea Boyle Tippett
University of Delaware

Public Release: 14-Apr-2014
Shared decision making during radiation therapy improves patient satisfaction
Playing an active role in their radiation treatment decisions leaves cancer patients feeling more satisfied with their care, and may even relieve psychological distress around the experience, researchers from the Perelman School of Medicine at the University of Pennsylvania report in the journal Cancer.
Penn Integrative Oncology Fund

Contact: Steve Graff
University of Pennsylvania School of Medicine

Public Release: 13-Apr-2014
Genetics & Development
Gene linked to pediatric kidney cancer suggests new strategies for kidney regeneration
Nearly one-third of cases of Wilms tumor, a pediatric cancer of the kidney, are linked to a gene called Lin28, according to research from Boston Children's Hospital. Mice engineered to express Lin28 in their kidneys developed Wilms tumor, which regressed when Lin28 was withdrawn, indicating that strategies aimed at blocking or deactivating the gene hold therapeutic promise. Studies also suggest that controlled expression of Lin28 can promote kidney development and therefore may hold clues to regeneration of damaged adult kidneys.
Ellison Medical Foundation and others

Contact: Irene Sege
Boston Children's Hospital

Public Release: 13-Apr-2014
Society for General Microbiology Annual Conference 2014
Reduction in HPV in young women in England seen, following national immunization program
A study conducted by Public Health England shows a reduction in two High Risk human papillomavirus types in sexually active young women in England, following the introduction of a national immunization program.

Contact: Francesca McNeil
Society for General Microbiology

Public Release: 13-Apr-2014
Nature Genetics
Virus-fighting genes linked to mutations in cancer
All cancer-causing processes leave a distinct mutational imprint or signature on the genomes of patients. A team from the Wellcome Trust Sanger Institute has found a major piece of biological evidence to support the role a group of virus-fighting genes has in cancer development. The mutational signature left by the cancer-causing process driven by this family of genes is found in half of all cancer types.

Contact: Mary Clarke
Wellcome Trust Sanger Institute

Public Release: 11-Apr-2014
Lancet Oncology
The Lancet Oncology: Challenges to effective cancer control in China, India, and Russia
New report from global cancer experts outlines barriers to cancer care and recent achievements in the three countries with more than half of the world's deaths from cancer.

Contact: Daisy Barton
The Lancet

Public Release: 11-Apr-2014
Nature Communications
Brain cell discovery could open doors to targeted cancer therapies
Fresh insights into the processes that control brain cell production could pave the way for treatments for brain cancer and other brain-related disorders.
Medical Research Council, Wellcome Trust

Contact: Catriona Kelly
University of Edinburgh

Public Release: 10-Apr-2014
Yeast provides genetic clues on drug response
Why do people respond differently to the same drug? For the first time, researchers have untangled genetic and environmental factors related to drug reactions, bringing us a step closer to predicting how a drug will affect us.
National Institutes of Health

Contact: Heather Amos
University of British Columbia

Public Release: 10-Apr-2014
Journal of Cancer Survivorship
Common sense health for young adult cancer survivors
Many factors influence the life expectancy of childhood cancer survivors: not getting enough exercise, being underweight, and being worried about their future health or their health insurance. These are the findings of research led by Cheryl Cox of the St. Jude Children's Research Hospital in the US, published in Springer's Journal of Cancer Survivorship. The study found that, on average, childhood cancer survivors passed away before they were 40 years old.

Contact: Alexander Brown
Springer Science+Business Media

Public Release: 10-Apr-2014
Nature Immunology
Enzyme revealed as promising target to treat asthma and cancer
In experiments with mice, Johns Hopkins Kimmel Cancer Center scientists have identified an enzyme involved in the regulation of immune system T cells that could be a useful target in treating asthma and boosting the effects of certain cancer therapies.
NIH/National Institute of Allergy and Infectious Diseases

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 10-Apr-2014
American Association for Cancer Research (AACR) Annual Meeting 2014
Tumor-suppressor connects with histone protein to hinder gene expression
A tumor-suppressing protein acts as a dimmer switch to dial down gene expression. It does this by reading a chemical message attached to another protein that's tightly intertwined with DNA, a team led by scientists at the University of Texas MD Anderson Cancer Center reported at the AACR Annual Meeting 2014.

Contact: Scott Merville
University of Texas M. D. Anderson Cancer Center

Showing releases 901-925 out of 1242.

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