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Showing releases 901-925 out of 1264.

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Public Release: 17-Jun-2014
Journal of Clinical Investigation
Heparin derivative suppresses neuroblastoma tumor growth
Researchers at Duke Medicine have identified a new strategy for treating neuroblastoma using a modified version of heparin, a century-old injectable drug that thins the blood to prevent clots from forming. The study, conducted in mice and published June 17, 2014, in the Journal of Clinical Investigation, found that when heparin is altered to remove its blood-thinning properties, it can suppress and shrink neuroblastoma tumors without causing severe bleeding.
National Institutes of Health, Alex's Lemonade Stand

Contact: Rachel Harrison
rachel.harrison@duke.edu
919-419-5069
Duke University Medical Center

Public Release: 17-Jun-2014
JAMA
TNF inhibitors for treatment of bowel disease not linked with increased risk of cancer
In a study that included more than 56,000 patients with inflammatory bowel disease, use of a popular class of medications known as tumor necrosis factor alpha antagonists was not associated with an increased risk of cancer over a median follow-up of 3.7 years, although an increased risk of malignancy in the long term, or with increasing number of doses, cannot be excluded, according to a study in the June 18 issue of JAMA.

Contact: Nynne Nyboe Andersen, M.D.
nyna@ssi.dk
The JAMA Network Journals

Public Release: 17-Jun-2014
JAMA
Study compares survival for treatments of uncommon eye cancer
In patients with advanced uveal melanoma, treatment with the agent selumetinib, compared with chemotherapy, resulted in an improved cancer progression-free survival time and tumor response rate, but no improvement in overall survival, according to a study in the June 18 issue of JAMA. The modest improvement in clinical outcomes was accompanied by a high rate of adverse events.

Contact: Courtney DeNicola Nowak
denicolc@mskcc.org
212-639-3573
The JAMA Network Journals

Public Release: 16-Jun-2014
Journal of Thoracic Oncology
No long-term anxiety or distress associated with low-dose computed tomography screening
Examination and review of several studies that evaluated patient-centered outcomes for individuals undergoing low-dose computed tomography screening for lung cancer found that screening does not appear to significantly influence overall health-related quality of life or result in long-term changes in anxiety or distress, but that positive results in the short-term, do increase distress levels.

Contact: Rob Mansheim
rob.mansheim@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Public Release: 16-Jun-2014
Advanced Functional Materials
Nanoscale composites improve MRI
Submicrometer particles that contain even smaller particles of iron oxide could make magnetic resonance imaging a far more powerful tool to detect and fight disease.
Cancer Prevention Research Institute of Texas, Natoinal Institutes of Health, Welch Foundation, Interpolytechnic Doctoral School, Turin, Italian Ministry of Research

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University

Public Release: 16-Jun-2014
JAMA Internal Medicine
Outreach doubles colon cancer screening in low-income communities
In low-income and minority communities where colonoscopies may be prohibitively expensive for residents, less-invasive, more frequent testing combined with automated reminders can yield dramatic improvements in colorectal cancer screening rates, a new study reports. Patients who received follow-up mailings, text messages and calls by staff were more than twice as likely to complete an at-home colon cancer screening test.
Agency for Healthcare Research and Quality

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University

Public Release: 16-Jun-2014
Journal of Thoracic Oncology
Improved diagnostic performance of low-dose computed tomography screening
Investigators of the COSMOS (Continuous Observation of SMOking Subjects) study show good compliance and patient survival outcomes using a 5-year low-dose computed tomography screening protocol in individuals at high-risk of developing lung cancer.

Contact: Rob Mansheim
rob.mansheim@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Public Release: 16-Jun-2014
Tobacco Control
Survey finds e-cigarette online market on fire
Researchers at the University of California, San Diego School of Medicine have completed the first comprehensive survey of e-cigarettes for sale online and the results, they believe, underscore the complexity in regulating the rapidly growing market for the electronic nicotine delivery devices.
NIH/National Cancer Institute

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 16-Jun-2014
Journal of the National Cancer Institute
Sedentary behavior increases the risk of certain cancers
Physical inactivity has been linked with diabetes, obesity, and cardiovascular disease, but it can also increase the risk of certain cancers, according to a study published June 16 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
Zachary.Rathner@oup.com
919-677-2697
Oxford University Press USA

Public Release: 16-Jun-2014
Annals of Internal Medicine
Annals of Internal Medicine tip sheet for June 17, 2014
The June 17, 2014, issue of Annals of Internal Medicine includes the following articles: 'To prevent stroke in women, start young' and 'Liver cancer screening may not increase survival in chronic hepatitis C.'

Contact: Megan Hanks
mhanks@acponline.org
215-351-2656
American College of Physicians

Public Release: 16-Jun-2014
Journal of Clinical Oncology
Majority of older breast cancer patients use hormone treatment
Women 65 years of age and older comprise about half of patients with breast cancer. Some studies suggest this group initiates therapy less often and discontinues treatment more frequently than younger or middle aged women. 'We found a more positive picture of use,' says the study author. Only 14 percent of the 65- to 91-year-olds in the study didn't start treatment. Non-white women much more likely to not have therapy.
National Institutes of Health

Contact: Karen Teber
km463@georgetown.edu
Georgetown University Medical Center

Public Release: 16-Jun-2014
JAMA Internal Medicine
Intervention increased adherence to fecal occult blood testing for colorectal cancer screening
A multipart intervention increased adherence rates of annual fecal occult blood testing for colorectal cancer screening in vulnerable populations.

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
The JAMA Network Journals

Public Release: 16-Jun-2014
Journal of Experimental Medicine
Lipids help to fight leukemia
T cells use a novel mechanism to fight leukemia. They may recognize unique lipids produced by cancer cells and kill tumor cells expressing these lipid molecules. A study conducted by researchers at the University of Basel shows that a tumor-associated lipid stimulates specific T cells, which efficiently kill leukemia cells both in vitro and in animal models. The results have been published in the Journal of Experimental Medicine.

Contact: Olivia Poisson
olivia.poisson@unibas.ch
University of Basel

Public Release: 16-Jun-2014
Nano Letters
Nanoshell shields foreign enzymes used to starve cancer cells from immune system
Nanoengineers at the University of California, San Diego have developed a nanoshell to protect foreign enzymes used to starve cancer cells as part of chemotherapy. Their work is featured on the June 2014 cover of the journal Nano Letters. Enzymes are naturally smart machines that are responsible for many complex functions and chemical reactions in biology. However, despite their huge potential, their use in medicine has been limited by the immune system, which is designed to attack foreign intruders.
National Cancer Institute

Contact: Catherine Hockmuth
chockmuth@ucsd.edu
858-822-1359
University of California - San Diego

Public Release: 16-Jun-2014
Genes & Development
Gene 'switch' reverses cancer in common childhood leukaemia
Melbourne researchers have shown a type of leukaemia can be successfully 'reversed' by coaxing the cancer cells back into normal development. The discovery was made using a model of B-progenitor acute lymphoblastic leukaemia, the most common cancer affecting children. Researchers from the Walter and Eliza Hall Institute showed that switching off a gene called Pax5 could cause cancer in a model of B-ALL, while restoring its function could 'cure' the disease.
National Health and Medical Research Council, Leukaemia Foundation, Sylvia and Charles Viertel Foundation, VESKI, Victorian Government

Contact: Liz Williams
williams@wehi.edu.au
61-428-034-089
Walter and Eliza Hall Institute

Public Release: 16-Jun-2014
Tobacco Control
E-cigs heavily marketed on Twitter, study finds
E-cigarettes, also known as vaping pens or e-hookas, are commonly advertised on Twitter and the tweets often link to commercial websites promoting e-cig use, according to University of Illinois at Chicago researchers.

Contact: Sherri McGinnis Gonzalez
smcginn@uic.edu
312-996-8277
University of Illinois at Chicago

Public Release: 16-Jun-2014
Medical Care
Most prostate cancer specialists don't recommend active surveillance for low-risk patients
Specialists who treat prostate cancer agree that active surveillance is an effective option -- yet most don't recommend it when appropriate for their own patients, according to a study in the July issue of Medical Care. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health

Public Release: 16-Jun-2014
Clinical Cancer Research
Low dose of targeted drug might improve cancer-killing virus therapy
Giving low doses of the targeted agent bortezomib with a cancer-killing virus might improve the effectiveness of the virus as a treatment for cancer with little added toxicity. The findings support the testing of this combination therapy in a clinical trial.
National Institutes of Health, Ohio State University Pelotonia Fellowship Program

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Wexner Medical Center

Public Release: 16-Jun-2014
Journal of Oncology Practice
When patients wish for a miracle, tool helps medical staff say 'amen'
Cancer clinicians and a chaplain at the Johns Hopkins Kimmel Cancer Center have developed a new tool to help doctors, nurses and other health-care providers talk to dying patients and families who are, literally, praying for a miracle.

Contact: Michelle Potter
mpotter8@jhmi.edu
410-614-2914
Johns Hopkins Medicine

Public Release: 16-Jun-2014
Nature Materials
Tugging on the 'malignant' switch
A team of Harvard researchers have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.
National Institutes of Health, National Science Foundation, Natural Sciences and Engineering Research Council of Canada, Howard Hughes Medical Institute, and others

Contact: Caroline Perry
cperry@seas.harvard.edu
Harvard University

Public Release: 16-Jun-2014
Cancer Prevention Research
Broccoli sprout drink enhances detoxification of air pollutants in clinical trial in China
A clinical trial involving nearly 300 Chinese men and women residing in one of China's most polluted regions found that daily consumption of a half cup of broccoli sprout beverage produced rapid, significant and sustained higher levels of excretion of benzene, a known human carcinogen, and acrolein, a lung irritant.
National Institutes of Health

Contact: Susan Sperry
ssperry1@jhu.edu
410-955-6919
Johns Hopkins University Bloomberg School of Public Health

Public Release: 16-Jun-2014
JAMA Internal Medicine
How to prevent disparities in colon cancer screening
People living in poverty are less likely to be screened for colorectal cancer -- and more likely to develop the disease and die from it. Mailing a stool test promises to help end these disparities, write Beverly Green, M.D., M.P.H., and Gloria Coronado, Ph.D., of Kaiser Permanente Center for Health Research in JAMA Internal Medicine.

Contact: Rebecca Hughes
hughes.r@ghc.org
206-287-2055
Group Health Research Institute

Public Release: 13-Jun-2014
Clinical Cancer Research
Tamoxifen-resistant breast cancer reversed when drug paired with anti-malaria agent
The inexpensive anti-malarial drug hydroxychloroquine reverses resistance to tamoxifen, a widely used breast cancer drug, in mice.
US Department of Defense, US Department of Health and Human Services

Contact: Karen Teber
km463@georgetown.edu
Georgetown University Medical Center

Public Release: 13-Jun-2014
Genetics in Medicine
Moffitt study shows utilizing genetic health care professional reduces unnecessary testing
A new Moffitt Cancer Center study published Thursday in Genetics in Medicine shows that counseling from a genetic health care provider before genetic testing educates patients and may help reduce unnecessary procedures.
Bankhead-Coley Cancer Research Program, NIH/National Cancer Institute

Contact: Kimberly Polacek
Kim.Polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 13-Jun-2014
Gynecologic Oncology
BRCA test results affect patients' breast cancer surgery plans
A new study reports that 7 in 10 women with breast cancer who learned before surgery they have BRCA gene mutations changed their surgical plan, often to a more extensive procedure that would reduce future cancer risk. The authors therefore recommend that women who meet genetic testing guidelines get the tests before surgery.

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

Showing releases 901-925 out of 1264.

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