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Showing releases 901-925 out of 1369.

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Public Release: 9-Mar-2015
Radiation plus immunotherapy combo revs up immune system to better attack melanoma, Penn study suggests
Treating metastatic melanoma with a triple threat --including radiation therapy and two immunotherapies that target the CTLA4 and PD-1 pathways -- could elicit an optimal response in more patients, one that will boost the immune system's attack on the disease, suggests a new study from a multidisciplinary team of researchers from Penn's Abramson Cancer Center published today in Nature.
Abramson Cancer Center, Melanoma Research Alliance, NIH/National Cancer Institute, Department of Defense and Basser Research Center for BRCA

Contact: Steve Graff
University of Pennsylvania School of Medicine

Public Release: 9-Mar-2015
Nature Nanotechnology
Innovative light therapy reaches deep tumors
Using a mouse model of cancer, researchers at Washington University School of Medicine in St. Louis have devised a way to apply light-based therapy to deep tissues never before accessible. Instead of shining an outside light, they delivered light directly to tumor cells, along with a photosensitive source of free radicals that can be activated by the light to destroy cancer. And they accomplished this using materials already approved for use in cancer patients.
National Institutes of Health, National Science Foundation

Contact: Julia Evangelou Strait
Washington University School of Medicine

Public Release: 9-Mar-2015
Breast cancer risk may be increased in women who have first-degree relatives with a history of prostate cancer
Having a family history of prostate cancer among first-degree relatives may increase a woman's risk of developing breast cancer.

Contact: Evelyn Martinez

Public Release: 9-Mar-2015
Nature Genetics
Fifteen new breast cancer genetic risk 'hot-spots' revealed
Scientists have discovered another 15 genetic 'hot-spots' that can increase a woman's risk of developing breast cancer, according to research published today in Nature Genetics.
Cancer Research UK, European Union, Canadian Institutes of Health Research, Ministry of Economic Development, Innovation and Export Trade of Quebec, National Institutes of Health

Contact: Liz Smith
Cancer Research UK

Public Release: 9-Mar-2015
DNA and Cell Biology
Viagra in combination with new drugs can have anti-cancer, antibacterial, and therapeutic effects
Chaperone proteins play an important role in protein folding in human cells and in bacteria and are promising new targets for drugs to treat cancer and Alzheimer's disease and for novel antiviral drugs and antibiotics. How existing drugs such as Viagra or Cialis and a derivative of the drug Celebrex, for example, can reduce the activity of a specific chaperone protein, with the potential for anti-tumor and anti-Alzheimer's disease effects, is described in a Review article in DNA and Cell Biology.

Contact: Kathryn Ryan
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 9-Mar-2015
Cancer Cell
Childhood leukemia study reveals disease subtypes, new treatment option
A new study of acute lymphoblastic leukemia (ALL), a blood cancer that primarily affects young children, has revealed that the disease has two distinct subtypes, and provides preliminary evidence that about 13 percent of ALL cases may be successfully treated with targeted drugs that have proved highly effective in the treatment of lymphomas in adults.
National Institutes of Health, NIH/National Cancer Institute, Hyundai Hope on Wheels, St. Baldrick's Foundation, Leukemia and Lymphoma Society, Tucker's Toy Box Foundation, William Lawrence and Blanche Hughes Foundation, and others

Contact: Pete Farley
University of California - San Francisco

Public Release: 9-Mar-2015
JAMA Internal Medicine
Vegetarian diet linked to lower risk of colorectal cancers
Eating a vegetarian diet was associated with a lower risk of colorectal cancers compared with nonvegetarians in a study of Seventh-Day Adventist men and women, according to an article published online by JAMA Internal Medicine.

Contact: Calvin Naito
The JAMA Network Journals

Public Release: 9-Mar-2015
Nature Cell Biology
Hippo 'crosstalk' may be vital to tumor suppression
Scientists at The University of Texas MD Anderson Cancer Center have discovered new information about a key pathway known as Hippo, a metaphoric name referencing its link to tissue 'overgrowth.' The Hippo pathway has been shown to regulate cell death and cell growth, thus playing a role in the development or prevention of tumors.

Contact: Ron Gilmore
University of Texas M. D. Anderson Cancer Center

Public Release: 9-Mar-2015
Journal of Clinical Investigation
From brain tumors to memory: A very multifunctional protein
A protein called BAI1 involved in limiting the growth of brain tumors is also critical for spatial learning and memory, researchers have discovered. BAI1 is part of a regulatory network neuroscientists think is connected with autism spectrum disorders.
NIH/National Cancer Institute, NIH/National Institute of Neurological Disorders and Stroke, Southeastern Brain Tumor Foundation, St. Baldricks

Contact: Quinn Eastman
Emory Health Sciences

Public Release: 9-Mar-2015
Nature Methods
New gene sequencing technology like a high-powered microscope
A new gene sequencing technology known as 'Capture Sequencing' allows us to explore the human genome at a much higher resolution than ever before, with revolutionary implications for research and cancer diagnosis.

Contact: Alison Heather
Garvan Institute of Medical Research

Public Release: 9-Mar-2015
The Journal of Mental Health
African-American cancer patients' depression symptoms under-recognized, CWRU study finds
Case Western Reserve University nurse scientist Amy Zhang, who has long examined quality-of-life issues in cancer patients, wondered whether depression in African-American cancer patients has been under-recognized for treatment.Accurately assessing depression in cancer patients is difficult in general because the physical symptoms of cancer and depression -- low energy, lack of sleep and loss of appetite -- are so similar.
NIH/National Institute of Cancer

Contact: Susan Griffith
Case Western Reserve University

Public Release: 9-Mar-2015
Understanding of cell enzyme flipped on its head
Researchers from Manchester, working with scientists in California, have found that certain molecules long thought to promote cancer growth, in fact suppress tumors, suggesting that therapeutic approaches should aim to restore, rather than block, their activity.

Contact: Jamie Brown
University of Manchester

Public Release: 9-Mar-2015
The EMBO Journal
Cancer-linked protein helps control fate of intestinal stem cells
An international group of researchers has shown that a regulatory protein involved in controlling how cancer spreads through the body also influences the fate of stem cells in the intestine of mice. The results show that the Snai1 protein plays an important role in deciding the fate of intestinal stem cells and the different functions that these cells can adopt.

Contact: Barry Whyte

Public Release: 8-Mar-2015
ENDO 2015: The 97th Annual Meeting & EXPO in San Diego, CA
Advanced thyroid cancer responds to targeted therapy with sunitinib
In patients with advanced thyroid cancer, sunitinib, a drug approved for treatment of several other cancers, showed significant cancer-fighting activity t, a new phase 2 clinical trial has found. Results of the single-center study will be presented Sunday at the Endocrine Society's 97th annual meeting in San Diego.

Contact: Aaron Lohr
The Endocrine Society

Public Release: 7-Mar-2015
ENDO 2015: The 97th Annual Meeting & EXPO in San Diego, CA
After breast cancer diagnosis, risk of thyroid cancer goes up
Breast cancer survivors are at increased risk of developing thyroid cancer, especially within five years of their breast cancer diagnosis, according to a new analysis of a large national database. The study results will be presented Thursday at the Endocrine Society's 97th annual meeting in San Diego.

Contact: Aaron Lohr
The Endocrine Society

Public Release: 7-Mar-2015
Scent-trained dog detects thyroid cancer in human urine samples
A trained scent dog accurately identified whether patients' urine samples had thyroid cancer or were benign (noncancerous) 88.2 percent of the time, according to a new study, to- be presented Friday at the Endocrine Society's 97th annual meeting in San Diego.

Contact: Aaron Lohr
The Endocrine Society

Public Release: 6-Mar-2015
The Oncologist
Oncologists see gene expression profiling tests as helpful but have concerns
Oncologists praise gene expression profiling tests as a decision-making tool for women with early-stage breast cancer but also have significant reservations.
Cancer Care Ontario, Ontario Institute for Cancer Research, Canadian Centre for Applied Research in Cancer Control

Contact: Leslie Shepherd
St. Michael's Hospital

Public Release: 6-Mar-2015
LGBT Health
Risk of breast cancer in transgender persons -- a study of veterans
A study of breast cancer in transgender veterans has identified 10 new cases, increasing the total number of published cases in both female-to-male and male-to-female transgender persons. Patient outcomes, use of cross-sex hormones, and recommendations for screening are presented in an article in LGBT Health.

Contact: Kathryn Ryan
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 6-Mar-2015
ENDO 2015: The 97th Annual Meeting & EXPO in San Diego, CA
Menopausal hormone therapy does not affect the risk of dying, study shows
Menopausal hormone therapy does not have a significant effect on death, according to a new review of the medical literature published over the past three decades. The results, which included studies with follow-up as long as 18 years, will be presented Friday at the Endocrine Society's 97th annual meeting in San Diego.

Contact: Aaron Lohr
The Endocrine Society

Public Release: 6-Mar-2015
Clinical and Translational Medicine
Review article provides new insights on how tumors metastasize
In a review article recently published in the journal Clinical and Translational Medicine, researchers from Boston University School of Medicine shed new light on the underlying processes of tumor metastasis and highlight the role of epigenetics in this process.

Contact: Gina DiGravio
Boston University Medical Center

Public Release: 6-Mar-2015
Nature Genetics
Chromosomal rearrangement is the key to progress against aggressive infant leukemia
The St. Jude Children's Research Hospital -- Washington University Pediatric Cancer Genome Project reports that a highly aggressive form of leukemia in infants has surprisingly few mutations beyond the chromosomal rearrangement that affects the MLL gene. The findings suggest that targeting the alteration is likely the key to improved survival. The research appeared online ahead of print this week in the scientific journal Nature Genetics.
Kay Jewelers, National Institutes of Health, Swedish Childhood Cancer Society, Swedish Research Council, Swedish Cancer Society, BioCARE, Gunnar Nilsson Cancer Foundation, ALSAC

Contact: Carrie Strehlau
St. Jude Children's Research Hospital

Public Release: 5-Mar-2015
Applied Physics Letters
Magnetic material attracts attention for cancer therapy
An extraordinary self-regulating heating effect that can be achieved in a particular type of magnetic material may open the doors to a new strategy for hyperthermia cancer treatment.

Contact: Glynis Smalley
Monash University

Public Release: 5-Mar-2015
Nature Immunology
Energetic immune cells are vital for fighting disease
A good immune system relies on a key 'energy producing' protein in immune cells to develop immunity to vaccines and disease, an international team of scientists has found.
National Health and Medical Research Council, Biotechnology and Biological Sciences Research Council, The Victorian Government

Contact: Alan Gill
Walter and Eliza Hall Institute

Public Release: 5-Mar-2015
Cellular and Molecular Gastroenterology and Hepatology
Understanding how the stomach responds to injury could help target therapy against gastric damage
A better understanding of the stomach's immune response to Helicobater pylori infection could lead to new therapies targeting damage in the stomach, report researchers in the March issue of Cellular and Molecular Gastroenterology and Hepatology, the basic science journal of the American Gastroenterological Association.
Victorian Government's Operational Infrastructure Support Program, National Health and Medical Research Council Australia

Contact: Rachel Steigerwald
American Gastroenterological Association

Public Release: 5-Mar-2015
ACS Nano
Medical nanoparticles: Local treatment of lung cancer
Nanoparticles can function as carriers for medicines to combat lung cancer: working in a joint project, scientists from the Helmholtz Zentrum München and the Ludwig-Maximilians-Universität in Munich have developed nanocarriers that site-selectively release medicines/drugs at the tumor site in human and mouse lungs. In the journal, ACS Nano, the scientists reported that this approach led to a significant increase in the effectiveness of current cancer medicines in lung tumor tissue.

Contact: Dr. Silke Meiners
Helmholtz Zentrum München - German Research Center for Environmental Health

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