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Public Release: 21-Dec-2015
Study finds that more than one-third of patients with metastatic cancer continue to work
A new analysis indicates that many patients continue working after being diagnosed with metastatic cancer, but a heavy burden of symptoms may prevent them from doing so. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study illustrates the need to treat difficult symptoms so that patients can maintain their employment.

Contact: Dawn Peters

Public Release: 21-Dec-2015
Nature Genetics
New target for potential blood cancer treatment
Mutations present in a blood cancer known as follicular lymphoma have revealed new molecular targets for potential treatments, according to researchers at Queen Mary University of London together with collaborators at the Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology.
Cancer Research UK, Kay Kendall Leukaemia Fund

Contact: Joel Winston
Queen Mary University of London

Public Release: 21-Dec-2015
Cancer Epidemiology, Biomarkers & Prevention
Periodontal disease associated with increased breast cancer risk in postmenopausal women
Postmenopausal women with periodontal disease were more likely to develop breast cancer than women who did not have the chronic inflammatory disease. A history of smoking significantly affected the women's risk.
NIH/National Heart, Lung and Blood Institute, National Institutes of Health, US Department of Health and Human Services

Contact: Lauren Riley
American Association for Cancer Research

Public Release: 21-Dec-2015
Journal of Clinical Investigation
Protein-protein interaction activates and fuels leukemia cell growth
Building upon previous research, scientists at University of California, San Diego School of Medicine and UC San Diego Moores Cancer report that a protein called Wnt5a acts on a pair of tumor-surface proteins, called ROR1 and ROR2, to accelerate the proliferation and spread of chronic lymphocytic leukemia cells, the most common form of blood cancer in adults.
California Institute for Regenerative Medicine, University of California San Diego Foundation Blood Cancer Research Fund, Leukemia and Lymphoma Society, National Institutes of Health

Contact: Scott LaFee
University of California - San Diego

Public Release: 20-Dec-2015
Scientific Reports
Study by NUS researchers unravels new interactions affecting TGF-β pathway in humans
Researchers from the Cancer Science Institute of Singapore at the National University of Singapore have delineated novel molecular interactions affecting the activity of the TGF-β pathway, a key cancer pathway in humans affecting cancer progression.

Contact: Goh Yu Chong
National University of Singapore

Public Release: 19-Dec-2015
ESMO Asia 2015 Congress
More patients with lung cancer could benefit from immunotherapy, study shows
More patients with advanced non-small-cell lung cancer (NSCLC) could benefit from pembrolizumab, says Professor Roy Herbst, Chief of Medical Oncology, Yale Cancer Center and Smilow Cancer Hospital at Yale-New Haven, presenting promising results from the pivotal phase 2/3 KEYNOTE-010 trial at the first ESMO Asia Congress in Singapore.

Contact: ESMO Press Office
European Society for Medical Oncology

Public Release: 19-Dec-2015
ESMO Asia 2015 Congress
Afatinib a better choice for EGFR-mutated lung cancer in first-line treatment
Patients with EGFR-activating mutations in advanced lung cancer seem to benefit more from afatinib than gefitinib as first-line treatment, researchers report at the first ESMO Asia 2015 Congress in Singapore.

Contact: ESMO Press Office
European Society for Medical Oncology

Public Release: 18-Dec-2015
Journal of General Internal Medicine
Uncovering potentially 'concerning' variation in cancer screening follow-ups
According to new study of one million patients, follow-up times for colorectal cancer screening abnormalities lag behind those for breast and cervical cancers.

Contact: Paige Stein
The Dartmouth Institute for Health Policy & Clinical Practice

Public Release: 18-Dec-2015
New model for vascular and tumor research
Two characteristic features of malignant tumors are that they form massive blood vessels and bypass the immune system. A new cell culture technique allows the processes of tumor growth to be studied directly and in real time, without the need for complex experiments using live animals. The researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg who developed the technique looked specifically at brain tumors.

Contact: Dr. Nicolai Savaskan
University of Erlangen-Nuremberg

Public Release: 18-Dec-2015
PLOS Genetics
BAP1 mutation passed down over centuries and is associated with high incidence of several cancers
Carbone and colleagues discovered that members of 4 families, apparently unrelated and living in different US States, shared the identical mutation of a gene called BAP1 that is associated with a higher incidence of mesothelioma, melanoma, renal carcinoma and other cancers. Through genetic and genealogical studies, it was demonstrated that the families were related, and that they descended from a couple that immigrated to the USA from Germany in the early 1700s.
National Institutes of Health, Department of Defense Congressionally Directed Medical Research Programs Peer Reviewed Cancer Research Program Career Development Award, V Foundation, University of Hawai'i Cancer Center

Contact: Amy Yau

Public Release: 18-Dec-2015
Breast Cancer: Targets and Therapy
NYU study identifies method for detecting latent stage of lymphedema
NYU Nursing researchers examined the validity, sensitivity, and specificity of symptoms for detecting breast cancer-related related lymphedema. The study also determined the best clinical cutoff point for the count of symptoms that maximized the sum of sensitivity and specificity.
Avon Foundation, NIH/-National Institute on Minority Health and Health Disparities

Contact: Christopher James
New York University

Public Release: 18-Dec-2015
ESMO Asia 2015 Congress
Asian women with endocrine-resistant breast cancer benefit from combination therapy
Data collected in Japanese and Korean patients included in the global PALOMA3 trial provides evidence that combining palbociclib with fulvestrant is an effective strategy to overcome endocrine resistance in women with hormone receptor positive (HR+), HER2 negative (HER2-) advanced breast cancer.

Contact: ESMO Press Office
European Society for Medical Oncology

Public Release: 18-Dec-2015
British Journal of Cancer
IU researchers find magnesium intake may be beneficial in preventing pancreatic cancer
Indiana University researchers have found that magnesium intake may be beneficial in preventing pancreatic cancer. Their study, 'Magnesium intake and incidence of pancreatic cancer: The VITamins and Lifestyle study,' recently appeared in the British Journal of Cancer. Using information from the VITamins and Lifestyle study, IU's study analyzed data on more than 66,000 men and women, between the ages of 50 and 76, looking at the direct association between magnesium and pancreatic cancer.

Contact: April Toler
Indiana University

Public Release: 17-Dec-2015
FSG publishes report by Esteller et al. validating new Illumina MethylationEPIC BEadChip
Epigenomics, the MEDLINE-indexed journal published by Future Science Group, is excited to announce the publication of the first study validating the MethylationEPIC BEadChip microarray -- the new and improved DNA methylation array from Illumina (CA, USA). The validation of this array provides the research community with a powerful new method for elucidating the role of the human epigenome in health and disease.

Contact: Leela Ripton
Future Science Group

Public Release: 17-Dec-2015
Immuno & targeted therapy provide new options for difficult-to-treat head&neck cancer
Novel strategies are on the way for difficult-to-treat and advanced head and neck cancer, the most heterogeneous group of malignancies which are generally associated with poor survival, and encouraging results have been presented at the first ESMO Asia 2015 Congress in Singapore.

Contact: ESMO Press Office
European Society for Medical Oncology

Public Release: 17-Dec-2015
Journal of Personalized Medicine
NYU nursing study examines obesity in relation to breast cancer related lymphedema
Lymphedema is a major health problem negatively affecting many breast cancer survivors survivors' quality of life. NYU researchers have shown this condition can be managed with early and appropriate treatment.
NIH/National Institute of Nursing Research, NIH/National Institute on Minority Health and Health Disparities

Contact: christopher james
New York University

Public Release: 17-Dec-2015
Journal of Comparative Effectiveness Research
Journal of Comparative Effectiveness research discusses oncology treatment sequences
Future Science Group (FSG) today announced the publication of a new article in the Journal of Comparative Effectiveness Research, discussing the recent recommendations from the Center for Medical Technology Policy's (CMTP) Green Park Collaborative (GPC-USA). The recommendations, released in August, discuss the conduct of studies that compare sequences of therapies in areas of advanced and metastatic cancer where a range of therapeutic options exist, but evidence is lacking on the optimal choices for sequential or combination therapy.

Contact: Leela Ripton
Future Science Group

Public Release: 17-Dec-2015
Architecture of mTOR protein complex solved
For a long time it has been known that the protein TOR - Target of Rapamycin -- controls cell growth and is involved in the development of diseases such as cancer and diabetes. Researchers at the University of Basel's Biozentrum together with scientists from ETH Zurich have now examined the structure of mammalian TOR complex 1 (mTORC1) in more detail. The scientists have revealed its unique architecture in their latest publication in Science.

Contact: Katrin Bühler
University of Basel

Public Release: 17-Dec-2015
Cancer drives patients to poverty in Southeast Asia
Five percent of cancer patients and their families were pushed into poverty in Southeast Asia between March 2012 and Sep. 2013, because of high disease-related costs, a study (1) at the inaugural ESMO Asia 2015 Congress in Singapore shows.

Contact: ESMO Press Office
European Society for Medical Oncology

Public Release: 17-Dec-2015
Journal of NeuroInterventional Surgery
'Smart fat cells' cross blood-brain barrier to catch early brain tumors
An MRI contrast agent that can pass through the blood-brain barrier will allow doctors to detect deadly brain tumors called gliomas earlier, say Penn State College of Medicine researchers. This ability opens the door to make this fatal cancer treatable.
Tara Leah Witmer Memorial Fund

Contact: Matt Solovey
Penn State

Public Release: 17-Dec-2015
Gastrointestinal Endoscopy
Endoscopic techniques offer hope for throat cancer patients
According to a study in the December issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE), endoscopic submucosal dissection (ESD) appears to be a safe and effective minimally invasive treatment for patients with superficial pharyngeal (throat) cancer.

Contact: Gina Steiner
American Society for Gastrointestinal Endoscopy

Public Release: 17-Dec-2015
Journal of Urology
Mental health status prior to bladder cancer surgery can indicate risk of complications
A patient's mental health prior to surgery can influence postoperative outcomes. Removal of the bladder, or radical cystectomy (RC), is an effective treatment for locally advanced bladder cancer, but complications occur in as many as 66% of patients. In a study in The Journal of Urology®, researchers found that patients whose self-assessment of mental health was low suffered more high grade complications in the 30 days following surgery than patients with higher self-assessments.

Contact: Linda Gruner
Elsevier Health Sciences

Public Release: 17-Dec-2015
Cancer Research
Prostate cancer discovery may make it easier to kill cancer cells
A newly discovered connection between two common prostate cancer treatments may soon make prostate cancer cells easier to destroy. Drugs that could capitalize on the discovery are already in the pipeline.
NIH/National Cancer Institute, Paul Mellon Urologic Cancer Institute

Contact: Josh Barney
University of Virginia Health System

Public Release: 17-Dec-2015
Angewandte Chemie
Pinpoint targeting instead of shotgun approach
Integrins help cells communicate with and adapt to their environment. Also cancer cells depend on their properties to survive and spread throughout the body. Now scientists at the Technical University of Munich (TUM) have successfully developed a small, highly active molecule that binds to a specific integrin that operates in many types of cancer. In the future it may allow patient-specific diagnoses and subsequent targeted treatment of tumor cells.
German Research Foundation

Contact: Dr. Andreas Battenberg
Technical University of Munich (TUM)

Public Release: 17-Dec-2015
Annals of Oncology
Pancreas cancer liquid biopsy flows from blood-borne packets of tumor genes
Pancreatic cancer tumors spill their molecular secrets into the blood stream, shedding their complete DNA and RNA wrapped inside protective lipid particles that make them ripe for analysis with a liquid biopsy, researchers at The University of Texas MD Anderson Cancer Center report online at the Annals of Oncology.

Contact: Scott Merville
University of Texas M. D. Anderson Cancer Center

Showing releases 926-950 out of 1299.

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