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Showing releases 926-950 out of 1198. << < 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 > >>
Public Release: 31-Dec-2012
 RadiologyPaired CT scans catch chemo-killing of liver tumors in real time Using two successive pairs of specialized CT scans, a team of Johns Hopkins and Dutch radiologists has produced real-time images of liver tumors dying from direct injection of anticancer drugs into the tumors and their surrounding blood vessels. 
NIH/National Cancer Institute, French Society of Radiology, Philips Research North America
Contact: David March
Public Release: 28-Dec-2012
Journal of the National Cancer InstituteTumor boards linked to little association with effects on cancer care There is little association of multidisciplinary tumor boards with measures of use, quality, or survival, and measuring only the presence of tumor boards may not be adequate in determining their effects on cancer care, according to a study published Dec. 28 in the Journal of the National Cancer Institute. Contact: Zachary Rathner
Public Release: 27-Dec-2012
PLOS BiologyThe factor that could determine future breast cancer treatment Australian scientists have shown how a 'transcription factor' causes breast cancer to develop an aggressive subtype that lacks sensitivity to oestrogen and does not respond to anti-oestrogen therapies such as Tamoxifen and aromatase inhibitors. Transcription factors are molecules that switch genes on or off. In this case, the transcription factor known as 'ELF5' inhibits sensitivity to oestrogen very early in the life of a breast cancer cell.
Garvan Institute of Medical Research
Contact: Iris Hui
Public Release: 27-Dec-2012
PLOS BiologyThe factor that could influence future breast cancer treatment Australian scientists have shown in the laboratory how a 'transcription factor' causes breast cancer cells to develop an aggressive subtype that lacks sensitivity to estrogen and does not respond to known anti-estrogen therapies. The research, which has significant implications for breast cancer treatment, is published Dec. 27 in the open access journal PLOS Biology. Contact: Bryan Ghosh
Public Release: 27-Dec-2012
Molecular CellUNC research uncovers new insight into cell development and cancer Research from the University of North Carolina at Chapel Hill School of Medicine has shed new light on how epigenetic signals may function together to determine the ultimate fate of a stem cell. The study, published Dec. 27, 2012 by the journal Molecular Cell, implicates a unique class of proteins called polycomb-like proteins as bridging molecules between the "on" and "off" state of a gene.
NIH/National Institutes of Health, US/Department of Defense, V Foundation for Cancer Research, University Cancer Research Fund
Contact: William Davis
Public Release: 27-Dec-2012
Frontiers in Cancer EpidemiologyUS cancer screening rates decline over the last 10 years, finds new study The rate of people who seek preventive cancer screenings has fallen over the last 10 years in the United States with wide variations between white-collar and blue-collar workers, according to a University of Miami Miller School of Medicine study published on Dec. 27 in the open-access journal Frontiers in Cancer Epidemiology. Contact: Gozde Zorlu
Public Release: 27-Dec-2012
Cell MetabolismCellular fuel gauge may hold the key to restricting cancer growth Researchers at McGill University have discovered that a key regulator of energy metabolism in cancer cells known as the AMP-activated protein kinase (AMPK) may play a crucial role in restricting cancer cell growth. AMPK acts as a "fuel gauge" in cells; Contact: Russell Jones
Public Release: 26-Dec-2012
New England Journal of MedicineDrug shortage linked to greater risk of relapse in young Hodgkin lymphoma patients A national drug shortage has been linked to a higher rate of relapse among children, teenagers and young adults with Hodgkin lymphoma enrolled in a national clinical trial, according to research led by St. Jude Children's Research Hospital. Contact: Robert Dicks
Public Release: 26-Dec-2012
New England Journal of MedicineDrug shortage linked to greater risk of relapse in young Hodgkin lymphoma patients A national drug shortage has been linked to a higher rate of relapse among children, teenagers and young adults with Hodgkin lymphoma enrolled in a national clinical trial, according to research led by St. Jude Children's Research Hospital. Contact: Summer Freeman
Public Release: 26-Dec-2012
Clinical Cancer ResearchAbility to metabolize tamoxifen affects breast cancer outcomes, Mayo Clinic-led study confirms For nearly a decade, breast cancer researchers studying the hormone therapy tamoxifen have been divided as to whether genetic differences in a liver enzyme affect the drug's effectiveness and the likelihood breast cancer will recur. Contact: Joe Dangor
Public Release: 26-Dec-2012
Molecular and Cellular BiologyNew technique catalogs lymphoma-linked genetic variations Cancer cells may harbor hundreds of mutations that set them apart from other cells in the body; the scientific challenge has been to figure out which mutations are culprits and which are innocent bystanders. Now, researchers at Johns Hopkins Medicine have devised a novel approach to sorting them out: They generated random mutations in a gene associated with lymphoma, tested the proteins produced by the genes to see how they performed, and generated a catalog of mutants with cancer-causing potential.
NIH/National Institute of Allergy and Infectious Diseases, American Cancer Society
Contact: Shawna Williams
Public Release: 26-Dec-2012
Proceedings of the National Academy of SciencesImmune system changes may drive aggressiveness of recurrent tumors The traditional view of recurrent tumors is that they are resistant to therapy because they've acquired additional genetic mutations that make them more aggressive and impervious to drugs. Now, however, researchers at the Perelman School of Medicine at the University of Pennsylvania show that the enhanced aggressiveness of recurrent tumors may be due to changes in the body's immune response.
National Institutes of Health, Paul Calabresi Scholarship, Lavin Family Foundation, National Lung Cancer Partnership
Contact: Jessica Mikulski
Public Release: 24-Dec-2012
Proceedings of the National Acadamy of SciencesNYU biologists identify proteins vital to chromosome segregation NYU biologists have identified how a vital protein is loaded by others into the centromere, the part of the chromosome that plays a significant role in cell division. Their findings shed new light on genome replication and may offer insights into the factors behind the production of abnormal numbers of chromosomes. Contact: James Devitt
Public Release: 24-Dec-2012
Proceedings of the National Acadamy of SciencesEnzyme accelerates malignant stem cell cloning in chronic myeloid leukemia An international team, headed by researchers at the University of California, San Diego School of Medicine, has identified a key enzyme in the reprogramming process that promotes malignant stem cell cloning and the growth of chronic myeloid leukemia, a cancer of the blood and marrow that experts say is increasing in prevalence.
California Institute for Regenerative Medicine, Government of Canada, Genome Canada
Contact: Scott LaFee
Public Release: 23-Dec-2012
Nature Genetics3 new genetic links to colorectal cancer Vanderbilt-Ingram Cancer Center investigators have identified three new genetic "hotspots" linked to colorectal cancer. These variants, reported Dec. 23 in an Advanced Online Publication in Nature Genetics, provide new insight into the biology of colorectal cancer -- and could represent new therapeutic targets for the disease.
NIH/National Cancer Institute
Contact: Dagny Stuart
Public Release: 23-Dec-2012
Nature Cell BiologyUnderstanding cell organization to tackle cancer Scientists at the University of Manchester have identified how cells know which way up they need to be. The discovery could help in the fight against cancer because in the early stages of the disease the cells become dis-organized.
Wellcome Trust
Contact: Morwenna Grills
Public Release: 23-Dec-2012
NatureResearch sheds new light on mechanisms of T-ALL, a form of leukemia that primarily affects children In collaboration with international research teams, scientists at VIB, KU Leuven and UZ Leuven have unmasked the ribosome -- the molecular machine in the cell that is involved in the production of proteins -- as a weak spot in leukemia cells. Their research has also shown that there is a difference in T-ALL between adults and children. Both findings can be important in the search for improved treatments for T-ALL.
Belgian Cancer Research Foundation, SymBioSys, FWO-Vlaanderen, European Research Council, Inter-University Attraction Pole
Contact: Kris Van der Beken
Public Release: 21-Dec-2012
Journal of Clinical InvestigationIroning out the link between H. pylori infection and gastric cancer In this issue of the Journal of Clinical Investigation, researchers led by Richard Peek at Vanderbilt University investigated the influence of iron on H. pylori-induced gastric cancer. Peek and colleagues found that low iron accelerated the development of H. pylori-associated cancerous lesions in gerbils.
National Institutes of Health, Department of Veterans Affairs
Contact: Jillian Hurst
Public Release: 21-Dec-2012
Journal of Clinical InvestigationJCI early table of contents for Dec. 21, 2012 This release contains summaries, links to PDFs, and contact information for the following newsworthy items to be published online, Friday, Dec. 21, 2012, in the JCI: The X factor in liver metabolism; Low iron levels increase the risk of H. pylori-associated gastric cancer; A critical genetic regulator of brown fat functionality; Dendritic cells play a protective role in atherosclerosis; and many more. Contact: Jillian Hurst
Public Release: 21-Dec-2012
Journal of Clinical InvestigationThomas Jefferson University researchers discover new pathways that drive metastatic prostate cancer Elevated levels of Cyclin D1b could function as a novel biomarker of lethal metastatic disease in prostate cancer patients, according to a pre-clinical study published ahead of print on Dec. 21 in the Journal of Clinical Investigation by researchers at the Kimmel Cancer Center at Jefferson.
NIH/National Cancer Institute, Prostate Cancer Foundation, Department of Defense
Contact: Steve Graff
Public Release: 21-Dec-2012
OncomiRsmiR-205 can be responsible for breast cancer Scientists demonstrated that the microRNAs expression can be potentially responsible for the abnormal acini formation of breast cancer cells. They observed that the overexpression of the miR-205 influences the morphology of acini, linking this miRNA to breast epithelial cell transformation. miR-205 appears not to be a simple tumor-suppressor miRNA in breast as previously believed, but it can be overexpressed in transformed cells and can influence the morphology of acini. Contact: Maria Hrynkiewicz
Public Release: 21-Dec-2012
PLOS OneStudy probes why and how patients with lung cancer initially get diagnosed with the disease Dr. David Gerber, an oncologist and assistant professor of internal medicine, has used the electronic medical records data of more than 400 patients in a single-center study that is further exploring results from the National Lung Screening Trial (NLST) released in 2010. Contact: Alex Lyda
Public Release: 20-Dec-2012
Cancer ResearchGame changing diagnostic & prognostic prostate cancer genetic tests revealed by Jefferson Researchers at the Kimmel Cancer Center at Jefferson have developed potentially game-changing diagnostic and prognostic genetic tests shown to better predict prostate cancer survival outcomes and distinguish clinically-relevant cancers.
NIH/National Cancer Institute
Contact: Steve Graff
Public Release: 20-Dec-2012
BloodCultural, social factors identified as barriers to minority participation in stem cell donation New research examining the role of race and ethnicity in an individual's decision to become a donor for hematopoietic cell transplantation identifies several factors associated with varied participation rates in national donor registries across racial/ethnic groups. Results of this first-of-its-kind study are published online today in Blood, the Journal of the American Society of Hematology.
NIH/National Heart, Lung, and Blood Institute
Contact: Claire Gwayi-Chore
Public Release: 20-Dec-2012
Journal of Investigative DermatologySerendipity points to new potential target and therapy for melanoma A University of Colorado Cancer Center study in this month's edition of the Journal of Investigative Dermatology describes a new target and potential treatment for melanoma, the most dangerous form of skin cancer. MicroRNA can decide which genes in a cell's DNA are expressed and which stay silent. Melanoma tends to lack microRNA-26a, which makes the gene SODD go silent.
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
Contact: Garth Sundem
Showing releases 926-950 out of 1198. << < 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 > >>
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