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Public Release: 13-Jun-2014
Clinical Cancer Research
Tamoxifen-resistant breast cancer reversed when drug paired with anti-malaria agent
The inexpensive anti-malarial drug hydroxychloroquine reverses resistance to tamoxifen, a widely used breast cancer drug, in mice.
US Department of Defense, US Department of Health and Human Services

Contact: Karen Teber
km463@georgetown.edu
Georgetown University Medical Center

Public Release: 12-Jun-2014
Blood
Cancer drug boosts levels of vascular-protective gene, KLF2
Case Western Reserve University researchers have discovered that an existing, drug, bortezomib, Velcade, used to help cancer patients has the potential to protect thousands of others from the often-deadly impact of vascular clots. As hematologist Lalitha Nayak, M.D., an assistant professor of medicine, reports in the June 12 edition of the journal Blood, the anti-thrombotic effects of bortezomib are determined by KLF2, part of a family of Kruppel-like factors -- master regulators of vascular health.
National Institutes of Health

Contact: Jeannette Spalding
jeannette.spalding@case.edu
216-368-3004
Case Western Reserve University

Public Release: 12-Jun-2014
Science
Broad Institute, MGH researchers chart cellular complexity of brain tumors
Scientists from the Broad Institute and Massachusetts General Hospital have conducted a first-of-its-kind study that characterizes the cellular diversity within glioblastoma tumors from patients. The study, which looked at the expression of thousands of genes in individual cells from patient tumors, revealed that the cellular makeup of each tumor is more heterogeneous than previously suspected. The findings, which appear online in Science Express, will help guide future investigations into potential treatments for this devastating disease.
Klarman Family Foundation, National Institutes of Health, Howard Hughes Medical Institute, and others

Contact: Haley Bridger
hbridger@broadinstitute.org
617-714-7968
Broad Institute of MIT and Harvard

Public Release: 12-Jun-2014
Immunity
Viral infections, including flu, could be inhibited by naturally occurring protein
By boosting a protein that naturally exists in our cells, an international team of researchers led by the University of Pittsburgh Cancer Institute, partner with UPMC CancerCenter, has found a potential way to enhance our ability to sense and inhibit viral infections. The laboratory-based discovery, which could lead to more effective treatments for viruses ranging from hepatitis C to the flu, appears in the June 19 issue of the journal Immunity.
NIH/National Institute of Allergy and Infectious Diseases

Contact: Allison Hydzik
hydzikam@upmc.edu
412-647-9975
University of Pittsburgh Schools of the Health Sciences

Public Release: 12-Jun-2014
Nanoscale
Antibodies from the desert as guides to diseased cells
Nanoparticles are considered a promising approach in detecting and fighting tumour cells. The method has, however, often failed because the human immune system recognizes and rejects them before they can fulfil their function. Researchers at Helmholtz-Zentrum Dresden-Rossendorf and at University College Dublin have developed nanoparticles that bypass the body's defence system and find the diseased cells. This procedure uses fragments from an antibody that only occurs in camels and llamas.

Contact: Simon Schmitt
s.schmitt@hzdr.de
49-351-260-3400
Helmholtz-Zentrum Dresden-Rossendorf

Public Release: 12-Jun-2014
BJU International
Low cholesterol linked with worse survival in patients with kidney cancer
People are often told to reduce their cholesterol to improve their heart health, but new research suggests that low cholesterol may increase kidney cancer patients' risk of dying from their disease. The findings, which are published in BJU International, indicate that cholesterol testing may help doctors as they monitor and treat patients with kidney cancer.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
201-748-6358
Wiley

Public Release: 12-Jun-2014
Cancer Epidemiology, Biomarkers & Prevention
Childhood cancer survivors hospitalized frequently years after cancer treatment
Survivors of childhood cancers were hospitalized more often and for longer durations because of blood disorders and other problems, many years after cancer treatment was completed, compared with the general population, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
National Institutes of Health, Huntsman Cancer Foundation, Utah Cancer Registry, Primary Children's Medical Foundation Award

Contact: Lauren Riley
lauren.riley@aacr.org
215-446-7155
American Association for Cancer Research

Public Release: 11-Jun-2014
Science Translational Medicine
New tumor-targeting agent images and treats wide variety of cancers
Scientists at the University of Wisconsin Carbone Cancer Center report that a new class of tumor-targeting agents can seek out and find dozens of solid tumors, even illuminating brain cancer stem cells that resist current treatments.

Contact: Susan Lampert Smith
ssmith5@uwhealth.org
608-890-5643
University of Wisconsin-Madison

Public Release: 11-Jun-2014
Nature
Leukemia drug found to stimulate immunity against many cancer types
A class of drug currently being used to treat leukemia has the unexpected side-effect of boosting immune responses against many different cancers, reports a new study led by scientists at UCL. The drugs, called p110δ inhibitors, have shown such remarkable efficacy against certain leukemias in recent clinical trials that patients on the placebo were switched to the real drug. Until now, however, they have not been tested in other types of cancer.
Cancer Research UK, UK Biotechnology and Biological Sciences Research Council, Wellcome Trust

Contact: Harry Dayantis
h.dayantis@ucl.ac.uk
44-020-310-83844
University College London

Public Release: 11-Jun-2014
SPIE Medical Imaging
Journal of Medical Imaging
First articles published in new Journal of Medical Imaging
Research on methods for earlier diagnosis and monitoring of cancer, improved retinal image quality assessment, enhanced 3D imaging of breast tissue, more accurate imaging of the brain, and other topics are among the first articles published by the new Journal of Medical Imaging. Published by SPIE, the international society for optics and photonics, articles in the journal will be freely available through 2015.

Contact: Amy Nelson
amy@spie.org
360-685-5478
SPIE--International Society for Optics and Photonics

Public Release: 11-Jun-2014
Cochrane Library
Advanced breast cancer: Benefits of Trastuzumab (Herceptin) outweigh the risk of harm
In women with advanced (or metastatic) breast cancer, treatment with the breast cancer drug Trastuzumab (Herceptin) is associated with prolonged survival but also increases the risk of developing heart problems, a new systematic review shows. However, the review, published in The Cochrane Library, concludes that more women benefit from use of Trastuzumab than are harmed.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
201-748-6358
Wiley

Public Release: 11-Jun-2014
mBio
Fungal protein found to cross blood-brain barrier
In a remarkable series of experiments on a fungus that causes cryptococcal meningitis, a deadly infection of the membranes that cover the spinal cord and brain, investigators at UC Davis have isolated a protein that appears to be responsible for the fungus' ability to cross from the bloodstream into the brain.
National Institutes of Health

Contact: Carole Gan
carole.gan@ucdmc.ucdavis.edu
916-734-9047
University of California - Davis Health System

Public Release: 10-Jun-2014
Lung Cancer
ESMO survey sheds light on common clinical practice for incompletely resected lung cancer
A landmark survey of more than 700 specialists provides crucial real-world insight into the treatments most oncologists choose for lung cancer patients whose tumour has been incompletely resected, an expert from the European Society for Medical Oncology says.

Contact: ESMO Press Office
media@esmo.org
European Society for Medical Oncology

Public Release: 10-Jun-2014
CA: A Cancer Journal for Clinicians
Guidelines address long-term needs of prostate cancer survivors
New Prostate Cancer Survivorship Care guidelines outline posttreatment clinical follow-up care for long-term and late effects faced by an estimated 2.8 million prostate cancer survivors in the United States.
American Cancer Society

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society

Public Release: 10-Jun-2014
Leukemia
Game changer for leukemia therapy
Australian researchers are zeroing in on a promising new approach to killing off cancer cells in patients with leukemia.
Leukemia Foundation of Australia

Contact: Deborah White, University of Adelaide
deborah.white@sahmri.com
61-881-284-302
University of Adelaide

Public Release: 10-Jun-2014
PLOS Medicine
Moles linked to risk for breast cancer
Cutaneous nevi, commonly known as moles, may be a novel predictor of breast cancer, according to two studies published in this week's PLOS Medicine. Jiali Han and colleagues from Indiana University and Harvard University, United States, and Marina Kvaskoff and colleagues from INSERM, France, report that women with a greater number of nevi are more likely to develop breast cancer.
National Institutes of Health

Contact: Maya Sandler
medicinepress@plos.org
PLOS

Public Release: 10-Jun-2014
Nature Genetics
Mayo Clinic researchers discover new form of cancer
is is the story of two perfectly harmless genes. By themselves, PAX3 and MAML3 don't cause any problems. However, when they combine during an abnormal but recurring chromosomal mismatch, they can be dangerous. The result is a chimera -- a gene that is half of each -- and that causes biphenotypic sinonasal sarcoma. The tumor usually begins in the nose and may infiltrate the rest of the face, requiring disfiguring surgery to save the individual.

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic

Public Release: 10-Jun-2014
Cancer Research
New research could provide key to overcoming resistance to HER2 targeted cancer treatments
Scientists from Trinity College Dublin have made a significant discovery of a new biomarker which may help overcome resistance to newer and more targeted anti-cancer drugs, such as Herceptin, for HER2 positive cancers. These findings may also help the early identification of patients who will benefit more from these treatments. The findings have just been published in leading international, peer reviewed journal: Cancer Research, the most frequently cited cancer journal in the world.
Science Foundation Ireland, Marie Keating Foundation, European Union Framework Programme 7 Cooperation in Science & Technology

Contact: Yolanda Kennedy
yokenned@tcd.ie
353-189-63551
Trinity College Dublin

Public Release: 10-Jun-2014
Cancer
Mammography has led to fewer late-stage breast cancers, U-M study finds
In the last 30 years, since mammography was introduced, late-stage breast cancer incidence has decreased by 37 percent, a new study from the University of Michigan Comprehensive Cancer Center finds.

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 10-Jun-2014
Cancer Epidemiology, Biomarkers & Prevention
Limiting carbs could reduce breast cancer recurrence in women with positive IGF1 receptor
Dartmouth researchers have found that reducing carbohydrate intake could reduce the risk of breast cancer recurrence among women whose tumor tissue is positive for the IGF-1 receptor. The study, 'Risk of Breast Cancer Recurrence Associated with Carbohydrate Intake and Tissue Expression of IGFI Receptor,' will appear in the July issue of Cancer Epidemiology Biomarkers & Prevention.
NIH/National Cancer Institute, Walton Family Foundation, National Institutes of Health, NIH/National Institute of General Medical Sciences

Contact: Robin Dutcher
Robin.Dutcher@hitchcock.org
603-653-9056
The Geisel School of Medicine at Dartmouth

Public Release: 10-Jun-2014
Applied Physics B - Laser and Optics
Compact proton therapy for fight against cancer
The future face of modern-day anti-cancer therapy based on charged particles like protons could potentially involve using laser accelerators. However, these facilities will need to be reduced in terms of both size and cost compared to conventional ones. In the scientific journal, Applied Physics B, Dresden medical physicist Umar Masood is the first to present a new design for the entire complex machine – from the accelerator to the radiation site. In the process, he has successfully cut the facility's size in half.

Contact: Christine Bohnet
c.bohnet@hzdr.de
49-351-260-2450
Helmholtz-Zentrum Dresden-Rossendorf

Public Release: 9-Jun-2014
Circulation
Lifetime cancer risk from heart imaging low for most children; rises with complex tests
Children with heart disease are exposed to low levels of radiation during X-rays, which do not significantly raise their lifetime cancer risk. However, children who undergo repeated complex imaging tests that deliver higher doses of radiation may have a slightly increased lifetime risk of cancer, according to researchers at Duke Medicine.
National Institutes of Health, Mend a Heart Foundation

Contact: Rachel Harrison
rachel.harrison@duke.edu
919-419-5069
Duke University Medical Center

Public Release: 9-Jun-2014
Stem Cell Reports
Mount Sinai researchers identify protein that keeps blood stem cells healthy as they age
A protein may be the key to maintaining the health of aging blood stem cells, according to work by researchers at the Icahn School of Medicine at Mount Sinai recently published online in Stem Cell Reports.

Contact: Lucia Lee
NewsMedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 9-Jun-2014
ASCO 50th Annual Meeting
Journal of Clinical Oncology
Needle biopsy underused in breast cancer diagnosis, negatively impacting diagnosis and care
Needle biopsy, the standard of care radiological procedure for diagnosing breast cancer, is underused with too many patients undergoing the more invasive, excisional biopsy to detect their disease, according to research from the University of Texas MD Anderson Cancer Center.

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center

Public Release: 9-Jun-2014
Journal of Clinical Investigation
JCI online ahead of print contents for June 9, 2014
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers published online, June 9, 2014, in the JCI: 'Clinical trial evaluates ex vivo cultured cord blood,' 'Murine model of Ewing's sarcoma reveals tumor origins,' 'Vitamin B12-dependent taurine synthesis regulates growth and bone mass,' 'Hypomorphic PCNA mutation underlies a human DNA repair disorder,' 'Characterization of pandemic influenza immune memory signature after vaccination or infection,' and more.

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Showing releases 926-950 out of 1265.

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