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Showing releases 926-950 out of 1362.

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Public Release: 3-Mar-2015
Journal of Applied Physics
Flower-like magnetic nanoparticles target difficult tumors
Thanks to the work of an interdisciplinary team of researchers at the Dartmouth Center of Nanotechnology Excellence, funded by the National Institutes of Health, the next-generation magnetic nanoparticles may soon be treating deep-seated and difficult-to-reach tumors within the human body.

Contact: Jason Socrates Bardi
American Institute of Physics

Public Release: 3-Mar-2015
Cell Metabolism
Researchers investigate possible colon cancer risk for new generation of weight-loss drugs
Gastric bypass and similar stomach-shrinking surgeries are a popular option for obese patients looking to lose weight or treat type 2 diabetes. While the surgeries have been linked to a decreased risk in many cancers, the single outlier is colon cancer. In Cell Metabolism, scientists present work in mice that could explain this association and raise safety concerns for a new generation of weight-loss drugs that mimic the biological after effects of these procedures.

Contact: Joseph Caputo
Cell Press

Public Release: 3-Mar-2015
Public Health Reports
UTMB study shows testosterone being prescribed when not medically needed
A new study by the University of Texas Medical Branch found that 20 percent of men were prescribed testosterone despite having normal testosterone levels based on the Endocrine Society's guidelines. The study also found that 39 percent of new testosterone users did not have a prostate cancer screening during the year before treatment and 56 percent were not screened during the year after starting treatment.
National Institutes of Health

Contact: Donna Ramirez
University of Texas Medical Branch at Galveston

Public Release: 3-Mar-2015
Long-term follow-up of benign thyroid nodules shows favorable prognosis
After five years of follow-up, a majority of asymptomatic, benign thyroid nodules exhibited no significant change in size, or actually decreased in size, and diagnoses of thyroid cancer were rare, according to a study in the March 3 issue of JAMA.

Contact: Sebastiano Filetti
The JAMA Network Journals

Public Release: 3-Mar-2015
MR spectroscopy shows precancerous breast changes in women with BRCA gene
A magnetic resonance spectroscopy technique that monitors biochemical changes in tissue could improve the management of women at risk of breast cancer, according to a new study.

Contact: Linda Brooks
Radiological Society of North America

Public Release: 3-Mar-2015
Brain tumor patients fare better with private insurance, new study finds
Brain tumor patients who are uninsured or use Medicaid stay hospitalized longer and develop more medical complications than those with private insurance, University of Florida Health researchers have found.

Contact: Doug Bennett
University of Florida

Public Release: 3-Mar-2015
How much overdetection is acceptable in cancer screening?
People have highly variable views on how much overdetection is acceptable in cancer screening, finds a UK survey in The BMJ this week.

Contact: Gozde Zorlu

Public Release: 3-Mar-2015
Breast Cancer Research
'Stem cell' test could identify most aggressive breast cancers
Testing breast cancer cells for how closely they resemble stem cells could identify women with the most aggressive disease, a new study suggests. Researchers found that breast cancers with a similar pattern of gene activity to that of adult stem cells had a high chance of spreading to other parts of the body.
Medical Research Council, Institute of Cancer Research, Breakthrough Breast Cancer, Cancer Research UK

Contact: Henry French
Institute of Cancer Research

Public Release: 3-Mar-2015
Agreement on best estimates of breast cancer overdiagnosis urgently needed to inform women
More than any other debate about overdiagnosis, the discussion of breast cancer has spilt from the pages of the specialist medical press into the public domain, argues a public health expert in The BMJ this week.

Contact: Gozde Zorlu

Public Release: 2-Mar-2015
Nature Cell Biology
Researchers discover 'milk' protein that enables survival of the species
Australian researchers have discovered the protein MCL-1 is critical for keeping milk-producing cells alive and sustaining milk production in the breast. Without milk production, offspring cannot survive, making MCL-1 essential for survival of mammalian species.
National Health and Medical Research Council, Australian Cancer Research Foundation, National Breast Cancer Foundation, Cure Cancer Australia Foundation, Victorian Government

Contact: Liz Williams
Walter and Eliza Hall Institute

Public Release: 2-Mar-2015
FASEB Journal
Researchers identify the mitochondrial 'shield' that helps cancer cells survive
Scientists have moved closer to understanding why cancer cells can be so resilient, even when faced with the onslaught of nearly toxic drug cocktails, radiation, and even our own immune systems. A new research report appearing in the March 2015 issue of The FASEB Journal shows that intermediate filaments formed by a protein called 'vimentin' or VIF, effectively 'insulate' the mitochondria in cancer cells from any attempt to destroy the cell.

Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Public Release: 2-Mar-2015
American Journal of Clinical Oncology
Use of new systemic adjuvant therapy in gastrointestinal tumors increasing
A new study finds that the use of adjuvant systemic therapy for localized gastrointestinal stromal tumors has significantly increased over time and that patients treated with the therapy have better survival than those treated with surgery alone.
American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 2-Mar-2015
Inorganic Chemistry
Preventing the spread of cancer with copper molecules
Chemists at Bielefeld University have developed a molecule containing copper that binds specifically with DNA and prevents the spread of cancer. First results show that it kills the cancer cells more quickly than cisplatin -- a widely used anti-cancer drug that is frequently administered in chemotherapy. When developing the anti-tumor agent, Dr. Thorsten Glaser and his team cooperated with biochemists and physicists. The design of the new agent is basic research.

Contact: Dr. Thorsten Glaser
Bielefeld University

Public Release: 2-Mar-2015
Journal of Cell Biology
Sall4 is required for DNA repair in stem cells
A protein that helps embryonic stem cells retain their identity also promotes DNA repair. The findings raise the possibility that the protein, Sall4, performs a similar role in cancer cells, helping them survive chemotherapy.
Chinese Ministry of Science and Technology, California Institute for Regenerative Medicine

Contact: Rita Sullivan King
Rockefeller University Press

Public Release: 2-Mar-2015
Human Molecular Genetics
New data on the regulation of the genetic activity that protects against lung cancer
Scientists at the University of Granada, in collaboration with the universities of Harvard and Yale have provided new data for a better understanding of the alterations produced during the development of lung cancer, the tumor with the highest yearly death rate in Spain.

Contact: Pedro Medina Vico
University of Granada

Public Release: 2-Mar-2015
Journal of Clinical Oncology
US women's awareness of breast density varies
Disparities in the level of awareness and knowledge of breast density exist among US women, according to the results of a Mayo Clinic study published in the Journal of Clinical Oncology.

Contact: Joe Dangor
Mayo Clinic

Public Release: 2-Mar-2015
Nature Genetics
Healthy-looking prostate cells mask cancer-causing mutations
Prostate cells that look normal under the microscope may be hiding genetic mutations that could develop into cancer, prompting new ways to improve treatment for the disease, according to research published in Nature Genetics.
Cancer Research UK, Wellcome Trust

Contact: Greg Jones
Cancer Research UK

Public Release: 2-Mar-2015
TSRI scientists find clues to cancer drug failure
Scientists at The Scripps Research Institute have published a pair of studies showing how the primary protein responsible for multidrug chemotherapy resistance changes shape and reacts to therapeutic drugs.
National Institutres of Health, National Health and Medical Research Council CJ Martin Postdoctoral Research Fellowship

Contact: Madeline McCurry-Schmidt
Scripps Research Institute

Public Release: 2-Mar-2015
Current Biology
Sizing up cells: Study finds possible regulator of growth
Modern biology has attained deep knowledge of how cells work, but the mechanisms by which cellular structures assemble and grow to the right size largely remain a mystery. Now, Princeton University researchers may have found the key in a dynamic agglomeration of molecules inside cells.
National Institutes of Health, Searle Scholars Program, National Science Foundation, Damon Runyon Postdoctoral Fellowship

Contact: John Sullivan
Princeton University, Engineering School

Public Release: 2-Mar-2015
Health Affairs
US spends more on cancer care, saves fewer lives than Western Europe
Despite sharp increases in spending on cancer treatment, cancer mortality rates in the United States have decreased only modestly since 1970, Samir Soneji, Ph.D., of Dartmouth's Norris Cotton Cancer Center and The Dartmouth Institute for Health Policy & Clinical Practice has found.
NIH/National Cancer Institute, NIH/National Institute on Aging, National Center for Advancing Translational Sciences

Contact: Kirk Cassels
The Geisel School of Medicine at Dartmouth

Public Release: 2-Mar-2015
Proceedings of the National Academy of Sciences
MD Anderson study shows why some brain cancers resist treatment
Scientists at The University of Texas MD Anderson Cancer Center may have discovered why some brain cancer patients develop resistance to standard treatments including radiation and the chemotherapy agent temozolomide.

Contact: Ron Gilmore
University of Texas M. D. Anderson Cancer Center

Public Release: 2-Mar-2015
Proceedings of the National Academy of Sciences
New nanodevice defeats drug resistance
A nanodevice from MIT researchers can disable drug-resistance genes, then release cancer drugs.
NIH/National Cancer Institute, Marie Curie International Outgoing Fellowship

Contact: Sarah McDonnell
Massachusetts Institute of Technology

Public Release: 2-Mar-2015
Lycopene may ward off kidney cancer in older women
A higher intake by postmenopausal women of the natural antioxidant lycopene, found in foods like tomatoes, watermelon and papaya, may lower the risk of renal cell carcinoma, a type of kidney cancer.
NIH/National Heart, Lung and Blood Institute

Contact: Julie O'Connor
Wayne State University - Office of the Vice President for Research

Public Release: 2-Mar-2015
Respiratory Research
Researchers identify genes responsible for lung tumors
The lung transcription factor Nkx2-1 is an important gene regulating lung formation and normal respiratory functions after birth. Alterations in the expression of this transcription factor can lead to diseases such as lung interstitial disease, post-natal respiratory distress and lung cancer.
National Institutes of Health

Contact: Gina DiGravio
Boston University Medical Center

Public Release: 2-Mar-2015
Restoring ability to halt cell division may protect lung cells from cancer
Researchers led by a team at the University of Illinois at Chicago, have identified a novel role for a signaling mechanism in lung cells that permanently places them into a state of suspended animation called senescence. Alive but unable to do much of anything, including divide, senescent cells cannot become cancerous. Drugs that can induce senescence through this signaling pathway would represent a new class of chemotherapy.
US Department of Veterans Affairs, National Institutes Health

Contact: Sharon Parmet
University of Illinois at Chicago

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