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Showing releases 926-950 out of 1326.

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Public Release: 28-May-2015
PLOS Pathogens
HIV's sweet tooth is its downfall
HIV has a powerful sweet tooth. After the virus invades an immune cell, it craves sugar and nutrients from the cell to replicate and grow. Scientists discovered the switch that flips on the cell's sugar pipeline. Then they blocked the switch with an experimental compound, shutting down the pipeline and starving HIV to death. The virus was unable to replicate in human cells. Similar new compounds could be part of drug 'cocktails' to treat HIV.
National Institutes of Health, Northwestern Medicine's HIV Translational Research Center

Contact: Marla Paul
Northwestern University

Public Release: 28-May-2015
PLOS Genetics
Understanding taste bud renewal may help cancer patients suffering from taste dysfunction
Dany Gaillard and colleagues at the University of Colorado Anschutz Medical Campus have discovered a key molecular pathway that aids the renewal of taste buds, a finding that may help cancer patients suffering from an altered sense of taste during treatment. Their findings were published recently in the journal PLOS Genetics.
National Institutes of Health, NIH/National Institute for Deafness and Other Communication Disorders, American Heart Association

Contact: Amy Yau

Public Release: 28-May-2015
Cell Host & Microbe
Controlling typhoid bacterium key to prevent gallbladder cancer in India and Pakistan
Controlling bacterial infections responsible for typhoid fever could dramatically reduce the risk of gallbladder cancer in India and Pakistan, according to Cell Host & Microbe study. The findings establish the causal link between bacterial infection and gallbladder cancer, explaining why this type of cancer is rare in the West but common in India and Pakistan, where typhoid fever is endemic. Public policy changes inspired by this research could have an immediate impact.

Contact: Joseph Caputo
Cell Press

Public Release: 28-May-2015
Science Translational Medicine
Nineteen medical school deans join together to call for sustainable biomedical research funding
Unstable funding is threatening the viability of academic biomedical research in this country, according to a new paper published this week in the journal Science Translational Medicine. The paper was written jointly by the deans of 19 prominent medical schools around the country. Among this group is University of Maryland School of Medicine Dean E. Albert Reece.

Contact: David Kohn
University of Maryland School of Medicine

Public Release: 28-May-2015
JAMA Oncology
Estimating the global burden of cancer in 2013; 14.9 million new cases worldwide
Researchers from around the world have worked together to try to measure the global burden of cancer and they estimate there were 14.9 million new cases of cancer, 8.2 million deaths and 196.3 million years of a healthy life lost in 2013, according to a Special Communication published online by JAMA Oncology.

Contact: Rhonda Stewart
The JAMA Network Journals

Public Release: 28-May-2015
PLOS Genetics
CU Anschutz researchers discover key step in how taste buds regenerate
Researchers at the University of Colorado Anschutz Medical Campus have discovered a key molecular pathway that aids in the renewal of taste buds, a finding that may help cancer patients suffering from an altered sense of taste during treatment.

Contact: David Kelly
University of Colorado Anschutz Medical Campus

Public Release: 28-May-2015
JAMA Ophthalmology
Metformin use associated with reduced risk of developing open-angle glaucoma
Taking the medication metformin hydrochloride was associated with reduced risk of developing the sight-threatening disease open-angle glaucoma in people with diabetes, according to a study published online by JAMA Ophthalmology.

Contact: Aimee S. Bergquist
The JAMA Network Journals

Public Release: 28-May-2015
Ancient DNA may provide clues into how past environments affected ancient populations
A new study by anthropologists from The University of Texas at Austin shows for the first time that epigenetic marks on DNA can be detected in a large number of ancient human remains, which may lead to further understanding about the effects of famine and disease in the ancient world.
Sigma Xi

Contact: Rachel Griess
University of Texas at Austin

Public Release: 28-May-2015
Annals of Oncology
Challenges ahead for European clinical trials
The European Society for Medical Oncology, in collaboration with the European Organisation for Research and Treatment of Cancer, expressed their views on the EU Clinical Trials Regulation in an official position paper recently published in Annals of Oncology.

Contact: ESMO Press Office
European Society for Medical Oncology

Public Release: 28-May-2015
JAMA Oncology
New cancer cases rise globally, but death rates are declining in many countries
New cases of virtually all types of cancer are rising in countries globally -- regardless of income -- but the death rates from cancer are falling in many countries, according to a new analysis of 28 cancer groups in 188 countries.

Contact: Rhonda Stewart
Institute for Health Metrics and Evaluation

Public Release: 28-May-2015
Cell Reports
Sanford-Burnham researchers identify a new target for treating drug-resistant melanoma
A study explains why some melanoma tumors are resistant to BRAF inhibitor treatment.
Melanoma Research Foundation, Hervey Family Non-endowment Fund at the San Diego Foundation

Contact: Susan Gammon
Sanford-Burnham Prebys Medical Discover Institute

Public Release: 27-May-2015
Deutsches Ärzteblatt International
Hodgkin's lymphoma: The treatment can have late sequelae
Hodgkin's lymphoma -- cancer of the lymph nodes -- arises in more than 150 children and adolescents in Germany each year. Nine out of 10 patients survive the disease, thanks to the highly effective treatments that are now available. Depending on the type of treatment given, however, there may be late sequelae, as discussed by Wolfgang Dörffel and colleagues in an original article in the current issue of Deutsches Ärzteblatt International.

Contact: Dr. Wolfgang Dörffel
Deutsches Aerzteblatt International

Public Release: 27-May-2015
Nature Genetics
UMN research identifies potential proteins to target in osteosarcoma treatment
New models developed at the Masonic Cancer Center, University of Minnesota reveal the genes and pathways that, when altered, can cause osteosarcoma. The information could be used to better target treatments for the often-deadly type of cancer. The new research is published in Nature Genetics.
NIH/National Cancer Institute, American Cancer Society, Karen Wyckoff Rein in Sarcoma Foundation, Zach Sobiech Osteosarcoma Fund of the Children's Cancer Research Fund

Contact: Caroline Marin
University of Minnesota Academic Health Center

Public Release: 27-May-2015
Study could explain why ovarian cancer treatments fail
Ovarian cancer cells can lock into survival mode and avoid being destroyed by chemotherapy, an international study reports.

Contact: Gemma Ward
University of Queensland

Public Release: 27-May-2015
Science Translational Medicine
Diagnosing cancer with help from bacteria
Engineers at MIT and the University of California at San Diego have devised a new way to detect cancer that has spread to the liver, by enlisting help from probiotics -- beneficial bacteria similar to those found in yogurt.
Ludwig Center for Molecular Oncology at MIT, National Institutes of Health, NIH/National Cancer Institute

Contact: Sarah McDonnell
Massachusetts Institute of Technology

Public Release: 27-May-2015
Machine-learning breakthrough paves way for medical screening, prevention and treatment
A breakthrough in machine learning has also brought about a 'game changer' for the science of metabolomics -- and will hasten the development of diagnostic and predictive tests for Alzheimer's, cancer, diabetes and numerous other conditions, leading to improved prevention and treatment.

Contact: Scott Lingley
University of Alberta

Public Release: 27-May-2015
Researchers identify origin of chromosomal oddity in some cancer cells
A new technique allows scientists to connect specific genetic abnormalities to cell behavior.
National Institutes of Health, Dana-Farber Cancer Institute/Bridge Project, MIT/Koch Institute, Claudia Adams Barr Program in Innovative Cancer Research, Leukemia and Lymphoma Society, and Howard Hughes Medical Institute

Contact: Teresa M Herbert
Dana-Farber Cancer Institute

Public Release: 27-May-2015
Clinical Neurology and Neurosurgery
Endoscopic removal of spinal tumor with the patient awake at Rhode Island Hospital
Albert Telfeian, M.D., a neurosurgeon at Rhode Island Hospital and Hasbro Children's Hospital, performed the first reported case of extracting the tumor endoscopically while the 16 year-old patient was awake and under a local anesthetic. The minimally invasive procedure enabled accurate diagnosis, which evaded multiple physicians previously. The case report was published online in the journal, Clinical Neurology and Neurosurgery, and will appear in the July 2015 issue.

Contact: Beth Bailey

Public Release: 27-May-2015
JAMA Dermatology
A sight for sore eyes: Visually training medical students to better identify melanomas
Research from the University of Alberta's Faculty of Medicine & Dentistry is helping to improve the ability of medical students and health professionals to detect early forms of skin cancer. The study, published in JAMA Dermatology, concludes that traditional teaching methods can be improved substantially by training health professionals to put a greater focus on the visual aspects of the task, as opposed to an emphasis on learning the physiology and anatomy of skin lesions.
University Hospital Foundation, University of Alberta/Faculty of Medicine & Dentistry

Contact: Ross Neitz
University of Alberta Faculty of Medicine & Dentistry

Public Release: 27-May-2015
New England Journal of Medicine
Importance of clinically actionable results in genetic panel testing for cancer
While advances in technology have made multigene testing, or 'panel testing,' for genetic mutations that increase the risk of breast or other cancers an option, authors of a review published today in the New England Journal of Medicine say larger studies are needed in order to provide reliable risk estimates for counseling these patients.

Contact: Katie Delach
University of Pennsylvania School of Medicine

Public Release: 27-May-2015
Science of the Total Environment
Roadside air can be more charged than under a high-voltage power line
More charged particles in urban environments come from motor vehicle emissions than anything else which makes living beside a busy road with lots of diesel-driven vehicles worse for your health than living under high voltage power lines.

Contact: Amanda Weaver
Queensland University of Technology

Public Release: 27-May-2015
2015 ASCO Annual Conference
Promising trial of brigatinib shows all next-gen ALK inhibitors may not be created equal
Phase I/II clinical trial results reported at the American Society for Clinical Oncology Annual Meeting 2015 show promising results for investigational drug brigatinib against ALK+ non-small cell lung cancer, with 58 of 78 ALK+ patients responding to treatment, including 50 of 70 patients who had progressed after previous treatment with crizotinib, the first licensed ALK inhibitor. Progression-free survival in patients previously treated with crizotinib was 13.4 months.

Contact: Erika Matich
University of Colorado Anschutz Medical Campus

Public Release: 27-May-2015
2015 ASCO Annual Conference
ASCO: Trial creates 6 percent weight loss after breast cancer treatment
Obesity is a risk factor for breast cancer. A multi-institutional study presented at the American Society for Clinical Oncology Annual Meeting 2015 shows that female breast cancer survivors are able to lose weight through modest lifestyle changes.

Contact: Erika Matich
University of Colorado Anschutz Medical Campus

Public Release: 27-May-2015
Tumor surroundings are shown to affect progression of different cancer subtypes
Our environment can have a major impact on how we develop, and it turns out it's no different for cancer cells. In work published today in Neoplasia, a team of researchers reports that two different mouse models of breast cancer progressed differently based on characteristics of the tumor microenvironment -- the area of tissue in which the tumor is embedded.
National Institutes of Health, Breast Cancer Alliance, Long Island 2 Day Walk to Fight Breast Cancer, Manhasset Women's Coalition Against Breast Cancer, University of Copenhagen, Augustinus Fonden, Dagmar Marshalls Fund

Contact: Peter Tarr
Cold Spring Harbor Laboratory

Public Release: 27-May-2015
Environmental Microbiology
Pinpointing natural cancer drug's true origins brings sustainable production a step closer
For decades, scientists have known that ET-743, a compound extracted from a marine invertebrate called a mangrove tunicate, can kill cancer cells. The drug has been approved for use in patients in Europe and is in clinical trials in the US.
International Cooperative Biodiversity Groups, Fogarty International Center, National Science Foundation, DOE/Joint Genome Institute

Contact: Ian Demsky
University of Michigan

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