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Showing releases 926-950 out of 1260.

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Public Release: 21-Jul-2015
Nature Chemical Biology
New 'TripAdvisor' site to address use of substandard biomedical research tools
An international panel of leading scientists is launching a new TripAdvisor-style website aimed at helping researchers choose better-quality research tools - and avoiding potentially serious errors in biomedical research. In a 'call to action' published today, the international expert panel warns that many scientists are unwittingly using poor-quality chemical probes, leading to mistaken conclusions being drawn from research studies.
The Institute of Cancer Research, Broad Institute, Structural Genomics Consortium, Wellcome Trust

Contact: Claire Bithell
Institute of Cancer Research

Public Release: 21-Jul-2015
Examination of use of diabetes drug pioglitazone and risk of bladder cancer
Although some previous studies have suggested an increased risk of bladder cancer with use of the diabetes drug pioglitazone, analyses that included nearly 200,000 patients found no statistically significant increased risk, however a small increased risk could not be excluded, according to a study in the July 21 issue of JAMA.

Contact: Janet Byron
The JAMA Network Journals

Public Release: 21-Jul-2015
Applying New Jersey population traits to Louisiana reverses colorectal cancer trends
If Louisiana had the same risk factors, screening uptake, and survival rates as New Jersey, incidence and mortality from the disease would drop to levels below that of New Jersey.
NIH/National Cancer Institute, American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 21-Jul-2015
Angewandte Chemie International Edition
Dartmouth team conducts first synthesis of molecules that cause rapid cell death in cancer
Dartmouth researchers and their colleagues have carried out the first total syntheses of certain compounds involved in excessive cell death in leukemia.
American Cancer Society, National Institutes of Health, Welch Foundation

Contact: John Cramer
Dartmouth College

Public Release: 21-Jul-2015
American Journal of Men's Health
Fatherhood makes men fat
Men gain weight after they become fathers for the first time, reports a large new Northwestern study that tracked the weight of more than 10,000 men from adolescence to young adulthood. The 'fatherhood effect' is an average weight gain of 3.5 to 4.5 pounds after the first child. Men who do not become fathers lose weight during this period. This is a key time for pediatricians to counsel fathers, who often don't have their own doctors.
National Institutes of Men's Health

Contact: Marla Paul
Northwestern University

Public Release: 21-Jul-2015
Cochrane Library
Study shows targeting bacteria causing ulcers may prevent stomach cancer
A research review for the Cochrane Library, led by McMaster University researchers, has found that eliminating Helicobacter pylori bacterium -- the main cause of stomach ulcers - with a short course of therapy of two commonly used medicines may help to reduce the risk of gastric cancer.

Contact: Susan Emigh
905-525-9140 x22555
McMaster University

Public Release: 21-Jul-2015
Proceedings of the National Academy of Sciences
PNAS: Evolution not just mutation drives development of cancer
A paper published today in the Proceedings of the National Academy of Sciences argues against the commonly held 'accumulation of mutations' model of oncogenesis in favor of a model that depends on evolutionary pressures acting on populations of cells.
NIH/National Cancer Institute

Contact: Garth Sundem
University of Colorado Anschutz Medical Campus

Public Release: 21-Jul-2015
Journal of Physiology
Blood vessels can actually get better with age
Oxidative stress has been linked to cardiovascular and neurodegenerative diseases including diabetes, hypertension and age-related cancers. However, researchers at the University of Missouri recently found that aging actually offered significant protection against oxidative stress. These findings suggest that aging may trigger an adaptive response to counteract the effects of oxidative stress on blood vessels.
National Institutes of Health

Contact: Jeffrey Hoelscher
University of Missouri-Columbia

Public Release: 20-Jul-2015
Nature Medicine
Stanford team links gene expression, immune system with cancer survival rates
Researchers at the Stanford University School of Medicine have compiled a database that integrates gene expression patterns of 39 types of cancer from nearly 18,000 patients with data about how long those patients lived.
Doris Duke Charitable Foundation, National Institutes of Health, B&J Cardan Oncology Research Fund, Ludwig Institute for Cancer Research, US Department of Defense, Siebel Stem Cell Institute, Thomas and Stacey Siebel Foundation

Contact: Krista Conger
Stanford University Medical Center

Public Release: 20-Jul-2015
Nature Medicine
T-cell receptor therapy achieves encouraging clinical responses in multiple myeloma
Results from a clinical trial investigating a new T cell receptor therapy that uses a person's own immune system to recognize and destroy cancer cells demonstrated a clinical response in 80 percent of multiple myeloma patients with advanced disease after undergoing autologous stem cell transplants.
National Institutes of Health, Multiple Myeloma Research Foundation, Adaptimmune

Contact: Steve Graff
University of Pennsylvania School of Medicine

Public Release: 20-Jul-2015
Current Biology
Mouse model tests health risks of circadian disturbances
People who work outside of the normal 9-5 schedule or experience frequent jet lag have been found to be at an increased risk for everything from weight gain to cancer, but there are too many variables involved to conduct multi-decade, controlled studies in humans to confirm whether sleep pattern disruption is a correlation or the cause. In Current Biology, researchers present the next best thing: a model that subjects mice to human-relevant circadian rhythm disturbances.

Contact: Joseph Caputo
Cell Press

Public Release: 20-Jul-2015
Journal of Clinical Oncology
Genomic fingerprint may predict aggressive prostate cancer in African-Americans
A set of genes could help stratify African-American men in need of more aggressive treatment for prostate cancer.

Contact: Edyta Zielinska
Thomas Jefferson University

Public Release: 20-Jul-2015
Nature Medicine
Study shows promise of precision medicine for most common type of lymphoma
A clinical trial has shown that patients with a specific molecular subtype of diffuse large B-cell lymphoma are more likely to respond to the drug ibrutinib (Imbruvica) than patients with another molecular subtype of the disease. The study appeared online July 20, 2015, in Nature Medicine.

Contact: NCI Press Officers
NIH/National Cancer Institute

Public Release: 20-Jul-2015
Nature Genetics
'Pill on a string' could help spot early signs of cancer of the gullet
A 'pill on a string' developed by researchers at the University of Cambridge could help doctors detect esophageal cancer -- cancer of the gullet -- at an early stage, helping them overcome the problem of wide variation between biopsies, suggests research published today in the journal Nature Genetics.
Medical Research Council, Cancer Research UK

Contact: Craig Brierley
University of Cambridge

Public Release: 20-Jul-2015
Life-saving breast cancer drugs going untaken in Appalachia
Nearly one-third of breast cancer survivors in Appalachia are not taking the critical, potentially life-saving follow-up treatment -- despite having insurance that would pay for it, a troubling new study has found.

Contact: Josh Barney
University of Virginia Health System

Public Release: 20-Jul-2015
Nature Medicine
Patients' own genetically altered immune cells show promise in fighting blood cancer
In recent years, immunotherapy has emerged as a promising treatment for certain cancers. Now this strategy, which uses patients' own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable. The results appeared in a study published online today in Nature Medicine.
National Institutes of Health, Multiple Myeloma Research Foundation, Adaptimmune

Contact: Karen Warmkessel
University of Maryland Medical Center

Public Release: 20-Jul-2015
Common chemicals may act together to increase cancer risk, study finds
Common environmental chemicals assumed to be safe at low doses may act separately or together to disrupt human tissues in ways that eventually lead to cancer, a task force reports.
Getting to Know Cancer

Contact: William Bisson
Oregon State University

Public Release: 20-Jul-2015
Journal of Clinical Oncology
MD Anderson study finds one-third of colorectal cancers diagnosed before 35 are hereditary
Hereditary colorectal cancers, caused by inherited gene mutations, are relatively rare for most patients. However, researchers at The University of Texas MD Anderson Cancer Center have discovered a particularly high prevalence of hereditary cancers among those diagnosed with the disease before the age of 35.

Contact: Clayton R. Boldt, Ph.D.
University of Texas M. D. Anderson Cancer Center

Public Release: 20-Jul-2015
Journal of Health Communication
Study: The Angelina Jolie Effect on breast cancer screening
Angelina Jolie received widespread media attention in 2013 when she told the public that she'd tested positive for BRCA1, a gene associated with an increased risk of breast and ovarian cancers, and subsequently had a double mastectomy. Now research shows that this publicity did influence some women's intentions to seek out similar genetic testing.

Contact: Matt Shipman
North Carolina State University

Public Release: 20-Jul-2015
Health Economics Review
Georgia State study finds state regulations linked to late cancer diagnoses
States' regulations of health insurance and practitioners significantly influence when patients receive colorectal or breast cancer diagnoses, especially among people younger than the Medicare-eligible age of 65, according to a new study by researchers at Georgia State University's School of Public Health and the University of North Carolina at Chapel Hill.

Contact: Anna Varela
Georgia State University

Public Release: 20-Jul-2015
Human Gene Therapy
New techniques improve specificity of CRISPR/Cas9 genome editing tools
To overcome the off-target mutations that commonly occur with CRISPR/Cas9 genome editing methods, researchers at Harvard Medical School and Massachusetts General Hospital have developed two strategies that greatly improve the specificity of RNA-guided nucleases for the DNA region targeted to be cut and repaired. A description of these new techniques and their successful use to modify human cancer cells and embryonic stem cells is described in a special issue on genome editing in Human Gene Therapy.

Contact: Kathryn Ryan
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 17-Jul-2015
Science Advances
Researchers discover a possible reason for drug resistance in breast tumors
Amplified levels of HER2 membrane proteins drive unrestricted cell growth in certain types of breast cancer. HER2-tailored antibody-based therapeutics aim to prevent cancer cell growth. However, two-thirds of the patients develop resistance against such therapeutics. Why, is not yet understood. Researchers now found out that HER2 dimers appeared to be absent from a small sub-population of resting SKBR3 breast cancer cells. This subpopulation may have self-renewing properties and thus may be resistant to antibody therapy.

Contact: Niels de Jonge
INM -Leibniz Insitute for New Materials

Public Release: 17-Jul-2015
Physicians testified for tobacco companies against plaintiffs with cancer, Stanford study finds
Despite scientific evidence to the contrary, a small group of otolaryngologists have repeatedly testified, on behalf of the tobacco industry, that heavy smoking did not cause the cancer in cases of dying patients suing for damages, according to a study by a Stanford University School of Medicine researcher.

Contact: Tracie White
Stanford University Medical Center

Public Release: 17-Jul-2015
Angewandte Chemie International Edition
Imaging glucose uptake activity inside single cells
Researchers at Columbia University have reported a new approach to visualize glucose uptake activity in single living cells by light microscopy with minimum disturbance. In a recent study published in Angewandte Chemie International Edition, Associate Professor of Chemistry Wei Min's team developed a new glucose analogue that can mimic the natural glucose, and imaged its uptake as energy source by living cancer cells, neurons and tissues at the single cell level.

Contact: Wei Min
Columbia University

Public Release: 17-Jul-2015
Nature Communications
Lymphomas tied to metabolic disruption
Researchers from The University of Texas Health Science Center at San Antonio found direct links between disrupted metabolism and an often fatal type of lymphoma.
National Institutes of Health, Cancer Prevention & Research Institute of Texas

Contact: Will Sansom
University of Texas Health Science Center at San Antonio

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