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Public Release: 2-Apr-2015
Personalized melanoma vaccines marshal powerful immune response
Personalized melanoma vaccines can be used to marshal a powerful immune response against unique mutations in patients' tumors, according to early data in a first-in-people clinical trial at Washington University School of Medicine in St. Louis. The research is reported April 2 in Science Express, in a special issue devoted to cancer immunology and immunotherapy.
Barnes-Jewish Hospital Foundation, Siteman Cancer Frontier Fund, Our Mark on Melanoma Foundation, Come Out Swinging Foundation, Blackout Melanoma Foundation, NIH/National Cancer Institute

Contact: Jim Goodwin
Washington University School of Medicine

Public Release: 2-Apr-2015
Nature Communications
Key mechanism identified in tumor-cell proliferation in pediatric bone cancers
A particular molecular pathway permits stem cells in pediatric bone cancers to grow rapidly and aggressively, according to researchers at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center.

Contact: David March
NYU Langone Medical Center / New York University School of Medicine

Public Release: 2-Apr-2015
An 'evolutionary relic' of the genome causes cancer
Pseudogenes have long been considered 'genomic junk,' mysterious remnants of evolution. Now, a scientific team in the Cancer Research Institute at Beth Israel Deaconess Medical Center has found that one of these evolutionary relics caused the development of an aggressive cancer in an animal model -- suggesting the need to sequence this vast genomic 'dark matter' in pursuit of precision cancer therapies.
National Institutes of Health, DOD Prostate Cancer Research Program, American Cancer Society, Cancer Research UK, Wellcome Trust, International Assn. for Cancer Research, Italian Assn. for Cancer Research, German Academy of Sciences Leopoldina

Contact: Bonnie Prescott
Beth Israel Deaconess Medical Center

Public Release: 2-Apr-2015
Palliative Medicine
Dying patients' choices not always aligned to caregivers'
An illuminating study compares the willingness of stage IV cancer patients, and their caregivers; to pay to extend their lives by one year against that of other end-of-life improvements. The research, led by members of the Lien Centre for Palliative Care and collaborators from the National Cancer Centre Singapore, was recently published in the journal, Palliative Medicine.
Lien Centre for Palliative Care

Contact: Dharshini Subbiah
Duke-NUS Graduate Medical School Singapore

Public Release: 2-Apr-2015
Journal of Thoracic Oncology
Physical activity benefits lung cancer patients and survivors
Exercise and physical activity should be considered as therapeutic options for lung cancer as they have been shown to reduce symptoms, increase exercise tolerance, improve quality of life, and potentially reduce length of hospital stay and complications following surgery for lung cancer.

Contact: Murry Wynes
International Association for the Study of Lung Cancer

Public Release: 2-Apr-2015
JAMA Oncology
Potential chemoresistance after consuming fatty acid in fish, fish oil
Researchers found that consuming the fish herring and mackerel, as well as three kinds of fish oils, raised blood levels of the fatty acid 16:4(n-3), which experiments in mice suggest may induce resistance to chemotherapy used to treat cancer, according to a study published online by JAMA Oncology.

Contact: Emile E. Voest
The JAMA Network Journals

Public Release: 2-Apr-2015
Cell Reports
Dual therapy's 1-2 punch knocks out drug-resistant lung cancer
Capitalizing on a rare opportunity to thoroughly analyze a tumor from a lung cancer patient who had developed resistance to targeted drug treatment, UC San Francisco scientists identified a biological escape hatch that explains the resistance, and developed a strategy in mice for shutting it down.
Bonnie J. Addario Lung Cancer Foundation, National Institutes of Health, Howard Hughes Medical Institute, Doris Duke Charitable Foundation, American Lung Association, Sidney Kimmel Foundation for Cancer Research, Searle Scholars Program, and others

Contact: Pete Farley
University of California - San Francisco

Public Release: 2-Apr-2015
Science Translational Medicine
NTU finds new treatment options for colon cancer
Scientists from Nanyang Technological University and Sweden's Karolinska Institutet have discovered that an existing chemotherapy drug used to treat leukemia could prevent and control the growth of colorectal tumors.
Nanyang Technological University's Lee Kong Chian School of Medicine, Singapore Millennium Foundation, National Cancer Centre Singapore, Swedish Research Council, Swedish Cancer Society, Karolinska Institutet, Tobias Foundation, and others

Contact: Lester Kok
Nanyang Technological University

Public Release: 2-Apr-2015
Cancer Letters
Nanoparticles may exploit tumor weaknesses to selectively attack cancers
Delving into the world of the extremely small, researchers are exploring how biodegradable nanoparticles can precisely deliver anticancer drugs to attack neuroblastoma, an often-deadly children's cancer. The approach may represent a new fourth arm of targeted pediatric cancer treatment, joining T-cell immunotherapy, radioactive isotopes and kinase inhibitors that disrupt cancer-driving signaling.
National Institutes of Health, Alex's Lemonade Stand Foundation, V Foundation

Contact: Rachel Salis-Silverman
Children's Hospital of Philadelphia

Public Release: 2-Apr-2015
Strong grasp of immune response dynamics will enhance checkpoint blockade
Spreading the success of cancer immunotherapy beyond those patients currently enjoying powerful, long-term responses to treatment requires greater understanding of the immune response to tumors, two leaders in the field note in a review in the April 3 Science.

Contact: Scott Merville
University of Texas M. D. Anderson Cancer Center

Public Release: 2-Apr-2015
Cancer Cell
Body's cancer defenses hijacked to make pancreatic and lung cancers more aggressive
Cancer Research UK scientists have discovered that a vital self-destruct switch in cells is hijacked -- making some pancreatic and non small cell lung cancers more aggressive, according to research published in Cancer Cell today.

Contact: Emily Head
Cancer Research UK

Public Release: 1-Apr-2015
Scientists drill down to genetic root of prostate tumor development
Scientists have revealed the root of prostate cancers in individual men, discovering that despite huge genetic variety between tumors they also share common gene faults -- insight that could offer new treatment hopes.

Contact: Emily Head
Cancer Research UK

Public Release: 1-Apr-2015
Science Translational Medicine
New knowledge on EphB signaling may improve treatment of intestinal cancers
A new study led by researchers at Sweden's Karolinska Institutet and Nanyang Technological University in Singapore, provides experimental evidence that a drug that inhibits the EphB-signaling pathway in the cell effectively can suppress the development of intestinal tumors.
Swedish Research Council, Swedish Cancer Society, Karolinska Institutet, Tobias Foundation, Knut and Alice Wallenberg Foundation, Torsten Söderberg Foundation, Singapore Millennium Foundation

Contact: KI Press Office
Karolinska Institutet

Public Release: 1-Apr-2015
Genes & Development
A CNIO team succeeds in doubling the life span of mice suffering from premature aging
An increase in the capacity to produce nucleotides, the 'building blocks' of DNA, reduces genome fragility and counteracts premature aging in mutant mice for the ATR protein. The experiments may explain the beneficial effects of folic acid, a precursor of nucleotides, which are clinically used to alleviate the degenerative symptoms associated with aging.

Contact: Nuria Noriega
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 1-Apr-2015
Cancer Epidemiology, Biomarkers & Prevention
Cancer prevention efforts in the US a mixed bag
While there has been substantial progress in some cancer control efforts in the past several decades, like reductions in smoking and increased utilization of cancer screening, progress in some areas is lagging, according to a new report.
American Cancer Society

Contact: David Sampson
American Cancer Society

Public Release: 1-Apr-2015
Cancer Epidemiology, Biomarkers & Prevention
Number of childhood cancer survivors increasing, most have morbidities
The prevalence of childhood cancer survivors is estimated to have increased, and the majority of those who have survived five or more years beyond diagnosis may have at least one chronic health condition.
National Institutes of Health

Contact: Lauren Riley
American Association for Cancer Research

Public Release: 1-Apr-2015
Locking up an oncogenic transcription
A novel molecule designed by scientists at the University of Massachusetts Medical School and the University of Virginia inhibits progression of a hard-to-treat form of recurring acute myeloid leukemia in patient tissue. The small molecule is one of the first designed to specifically target a cancer-causing transcription factor.

Contact: Jim Fessenden
University of Massachusetts Medical School

Public Release: 1-Apr-2015
Science Translational Medicine
Cancer's relentless evolution
In new research, Carlo Maley, Ph.D., and his colleagues describe compulsive evolution and dramatic genetic diversity in cells belonging to one of the most treatment-resistant and lethal forms of blood cancer: acute myeloid leukemia (AML). The authors suggest the research may point to new paradigms in both the diagnosis and treatment of aggressive cancers, like AML.

Contact: joseph Caspermeyer
Arizona State University

Public Release: 1-Apr-2015
PLOS Pathogens
Anticancer drug can spur immune system to fight infection
Imatinib, an example of a 'targeted therapy' against cancer, or related drugs might be tools to fight a variety of infections.
NIH/National Institute of Allergy and Infectious Diseases, NIH/National Heart, Lung, and Blood Institute

Contact: Quinn Eastman
Emory Health Sciences

Public Release: 1-Apr-2015
Study affirms lethal prostate cancer can spread from other metastatic sites
A new genomic analysis of tissue from patients with prostate cancer has added more evidence that cells within metastases from such tumors can migrate to other body parts and form new sites of spread on their own.
Cancer Research UK, Academy of Finland, Cancer Society of Finland, PELICAN Autopsy Study, Johns Hopkins Brady Urological Institute, John and Kathe Dyson, NIH/National Cancer Institute

Contact: Vanessa Wasta
Johns Hopkins Medicine

Public Release: 1-Apr-2015
BMJ Open
Older people at higher risk of emergency cancer diagnosis
People over 60 are at higher risk of being diagnosed with lung or bowel cancer as an emergency in hospital than younger people, according to a Cancer Research UK-supported report, published today by BMJ Open.
Part-funded by Cancer Research UK

Contact: Liz Smith
Cancer Research UK

Public Release: 1-Apr-2015
BMC Veterinary Research
Old cancer drug could have new use in fighting cancer
Jeffrey Bryan, an associate professor of oncology at the MU College of Veterinary Medicine, found that an old cancer drug can not only kill cancer cells, but also works to change how certain cancer cells function, weakening those cells so they can be killed by other drugs.

Contact: Nathan Hurst
University of Missouri-Columbia

Public Release: 31-Mar-2015
Nature Communications
Scientists reveal unique mechanism of natural product with powerful antimicrobial action
Scientists from the Florida campus of The Scripps Research Institute have uncovered the unique mechanism of a powerful natural product with wide-ranging antifungal, antibacterial, anti-malaria and anti-cancer effects. The new study sheds light on the natural small molecule known as borrelidin.
National Institutes of Health, Korean Global Frontier Project, and PGA Women's Cancer Awareness Foundation

Contact: Eric Sauter
Scripps Research Institute

Public Release: 31-Mar-2015
St. Gallen 2015: Latest multidisciplinary research in early breast cancer
The latest challenges of early breast cancer research include refining classification and predicting treatment responses, according to a report on the 14th St. Gallen International Breast Cancer Consensus Conference, published in ecancermedicalscience.

Contact: Katie Foxall

Public Release: 31-Mar-2015
Journal of Public Health Management and Practice
How did he do it? Mayor Bloomberg's public health strategy evaluated in Journal of Public Health Management and Practice
How did former New York City Mayor Michael Bloomberg succeed in achieving so much of his 'comprehensive and far-reaching' public health agenda? Key strategies included harnessing the full authority of the City health department and mobilizing the existing workforce to focus on targeted reforms, according to a study in the March/April issue of the Journal of Public Health Management and Practice. The journal is published by Wolters Kluwer.

Contact: Connie Hughes
Wolters Kluwer Health

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