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Public Release: 21-Apr-2016
Cell
Wellderly study suggests link between cognitive decline genes and healthy aging
An eight-year-long accrual and analysis of the whole genome sequences of healthy elderly people, or 'Wellderly,' has revealed a higher-than-normal presence of genetic variants offering protection from cognitive decline, researchers from the Scripps Translational Science Institute reported today in the journal Cell.
Scripps Health, Complete Genomics, Inova Health System, Odeen family, Gary and Mary West Foundation, Lavin Family Foundation

Contact: Keith Darce
darce.keith@scrippshealth.org
858-678-7121
Scripps Health

Public Release: 21-Apr-2016
Current Biology
The cell copying machine: How daughters look like their mothers
Tiny structures in our cells, called centrioles, control both cell division and motility. The number of these structures is highly monitored, with deviations causing infertility, microcephaly and cancer. A research team, from Instituto Gulbenkian de Ciencia, led by Monica Bettencourt-Dias, uncovered the mechanism by which mother cells know that they provide the right number of centrioles to their daughters, in a study now published in the scientific journal Current Biology.
Fundação para a Ciencia e a Tecnologia, European Molecular Biology Organization, European Research Council

Contact: Vanessa Borges
vborges@igc.gulbenkian.pt
Instituto Gulbenkian de Ciencia

Public Release: 21-Apr-2016
JAMA Oncology
No increased risk of fatal CV events for breast cancer patients on newer hormone therapy
In a new study from Kaiser Permanente, researchers found the use of aromatase inhibitors, hormone-therapy drugs used to treat patients with breast cancer, was not associated with an increased risk of fatal cardiovascular events, including heart attacks or stroke, compared with tamoxifen, another commonly prescribed anti-cancer drug that works on hormones and which has been associated with a serious risk of stroke.
California Breast Cancer Research Program, NIH/National Cancer Institute

Contact: Navneet Miller
navneet.miller@creation.io
415-262-5972
Kaiser Permanente

Public Release: 21-Apr-2016
Cell
Researchers identify new mechanism to target 'undruggable' cancer gene
RAS genes are mutated in more than 30 percent of human cancers and represent one of the most sought-after cancer targets for drug developers. A new study published in the April 20 issue of the journal Cell by researchers at the Icahn School of Medicine at Mount Sinai led by E. Premkumar Reddy, Ph.D., has identified a new mechanism for targeting this important cancer gene.
Onconova Therapeutics Inc, National Institutes of Health

Contact: Lucia Lee
newsmedia@mssm.edu
646-605-5940
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 21-Apr-2016
Journal of the National Cancer Institute
Young adult survivors of childhood cancer report feeling middle-aged
Do survivors of childhood cancer return to normal health as they grow up? New research from Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard T.H. Chan School of Public Health finds young adult survivors of childhood cancer , age 18-29, report health-related quality of life that resembles that of adults, 40-49, in the general population, according to a study in the Journal of the National Cancer Institute.
NIH/National Cancer Institute, American Lebanese-Syrian Associated Charities

Contact: Irene Sege
irene.sege@childrens.harvard.edu
617-919-7379
Dana-Farber Cancer Institute

Public Release: 21-Apr-2016
JAMA Oncology
No risk association observed for anthracycline chemotherapy, cognitive decline
New data analyses found no association between anthracycline chemotherapy and greater risk of cognitive decline in breast cancer survivors, according to an article published online by JAMA Oncology.

Contact: Peter M. Bracke
PBracke@mednet.ucla.edu
310-206-4430
The JAMA Network Journals

Public Release: 20-Apr-2016
Nature Communications
Brain stem cell quiescence needs to be actively maintained in Drosophila
Biologists at Johannes Gutenberg University Mainz in Germany have discovered that the phases of quiescence in the Drosophila fruit fly central nervous system are controlled by the Hippo signaling pathway.

Contact: Dr. Christian Berger
bergerc@uni-mainz.de
49-613-139-24328
Johannes Gutenberg Universitaet Mainz

Public Release: 20-Apr-2016
American Association for Cancer Research 2016 Annual Meeting
AACR: Targeting cancer with engineered T cells
Dr. Philip Greenberg, head of immunology and a member of the Clinical Research Division at Seattle's Fred Hutchinson Cancer Research Center and a leader in cancer immunology, will describe at AACR 2016 how he and colleagues are genetically engineering T cells to seek out cancer cells, penetrate their defenses and kill them.

Contact: Rhonda Curry
rcurry@fredhutch.org
206-240-6011
Fred Hutchinson Cancer Research Center

Public Release: 20-Apr-2016
Nature Communications
Targeted missiles against aggressive cancer cells
Targeted missiles that can enter cancer cells and deliver lethal cell toxins without harming surrounding healthy tissue. This has been a long-standing vision in cancer research, but it has proved difficult to accomplish. A research group at Lund University in Sweden has now taken some crucial steps in this direction.

Contact: Cecilia Schubert
cecilia.schubert@kommunikation.lu.se
46-073-062-3858
Lund University

Public Release: 20-Apr-2016
PLOS ONE
Taking aspirin could increase cancer survival by 20 percent
Patients receiving cancer treatment could increase their chance of survival by up to 20 percent and help stop their cancer from spreading by taking a low dose of aspirin, new research suggests.

Contact: Peter Elwood
Peter.c.elwood@gmail.com
07-837-340-199
Cardiff University

Public Release: 20-Apr-2016
Cancer Microenvironment
Stomach cancer diagnostics: New insights on stage of tumor growth
Researchers of Kazan Federal University and the National Academy of Sciences of Ukraine found correlations between the superoxide and nitric oxide generation rates, levels of active forms of MMP-2 and MMP-9 in tumor and adjoining tissues between each other and with the disease stages for gastric cancer patients.

Contact: Yevgeniya Litvinova
press@kpfu.ru
7-843-233-7345
Kazan Federal University

Public Release: 20-Apr-2016
Science Translational Medicine
Study finds explanation for some treatment-resistant breast cancers
The new study led by Vanderbilt-Ingram Cancer Center investigators has identified gene alterations that may explain why triple-negative breast cancer is resistant to most existing treatments, and suggests that a targeted therapy currently in clinical development may prove beneficial.
IBC Network Foundation, US Department of Defense, and NIH/National Cancer Institute

Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center

Public Release: 20-Apr-2016
JAMA Oncology
Detecting when the most common skin cancer turns dangerous
A team of researchers who specialize in treating cancers of the eye wanted to identified EZH2 as a marker for aggressive basal cell skin cancer. It may also provide a potential target for treatment.
National Institutes of Health, Genentech, Research to Prevent Blindness, NIH/National Eye Institute

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 20-Apr-2016
Nature
UMN researchers show 'dirty mice' could clean up immune system research
Scientists at the University of Minnesota have developed a new way to study mice that better mimics the immune system of adult humans and which could significantly improve ways to test potential therapeutics. Published online today in the journal Nature, the researchers describe the limitations of laboratory mice for immunology research and reveal the benefits of what they are calling 'dirty mice.'
National Institutes of Health

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center

Public Release: 19-Apr-2016
American Association for Cancer Research
Watercress extract detoxifies carcinogens in smokers, clinical trial demonstrates
Watercress extract taken multiple times a day significantly inhibits the activation of a tobacco-derived carcinogen in cigarette smokers, researchers at the University of Pittsburgh Cancer Institute, partner with UPMC CancerCenter, demonstrated in a phase II clinical trial presented today at the American Association for Cancer Research Annual Meeting in New Orleans.
NIH/National Cancer Institute

Contact: Amy Charley
CharleyA@upmc.edu
412-738-3511
University of Pittsburgh Schools of the Health Sciences

Public Release: 19-Apr-2016
Pediatric Blood and Cancer
Rare pediatric cancer successfully treated with new targeted therapy
When a baby's life was threatened by a rare pediatric cancer that would not respond to surgery or chemotherapy, doctors at Nemours Children's Hospital rapidly, successfully shrank the tumor by 90 percent using an experimental treatment, according to a new study published online in Pediatric Blood and Cancer. The now-20-month-old girl achieved the remarkable improvement by receiving a drug called LOXO-101 that was being tested on adults, researchers reported.
Loxo Oncology, Inc., Stamford, CT

Contact: Tamara Moore
tmoore@gymr.com
202-745-5114
The Reis Group

Public Release: 19-Apr-2016
American Association for Cancer Research 2016 Annual Meeting
Merkel cell carcinoma patients who received pembrolizumab often had durable responses
In a phase 2 clinical trial of the immunotherapy drug pembrolizumab as a first-line systemic therapy for advanced Merkel cell carcinoma, or MCC -- a rare, aggressive type of skin cancer -- the clinical response rate was similar to that typically seen with standard chemotherapy, but the duration of the response appeared to be markedly longer. There are currently no therapies that have been approved by the US Food and Drug Administration for this cancer.
NIH/National Cancer Institute

Contact: Rhonda Curry
rcurry@fredhutch.org
206-240-6011
Fred Hutchinson Cancer Research Center

Public Release: 19-Apr-2016
American Association for Cancer Research 2016 Annual Meeting
Immunotherapy is first to show survival benefit in head and neck cancer
The immunotherapy drug nivolumab has become the first to show a survival benefit in head and neck cancer, after a major international trial found that it was more effective than standard chemotherapy.
Bristol Myers Squibb

Contact: Henry French
henry.french@icr.ac.uk
020-872-25582
Institute of Cancer Research

Public Release: 19-Apr-2016
Human Reproduction
BRCA1 gene mutation is linked to women having fewer eggs in their ovaries
Researchers have discovered a link between the BRCA1 gene mutation and lower levels of a hormone that is an indicator of the number of eggs left in a woman's ovaries, according to research published in Human Reproduction, one of the world's leading reproductive medicine journals.
Australian National Breast Cancer Foundation

Contact: Emma Mason
wordmason@mac.com
European Society of Human Reproduction and Embryology

Public Release: 19-Apr-2016
Hepatology
Aspirin use may help prevent bile duct cancer, Mayo-led study finds
A team of current and former Mayo Clinic researchers has discovered that aspirin use is associated with a significantly reduced risk of developing bile duct cancer, also called cholangiocarcinoma. The results are published in Hepatology.

Contact: Joe Dangor
newsbureau@mayo.edu
507-284-5005
Mayo Clinic

Public Release: 19-Apr-2016
Proceedings of the National Academy of Sciences
New class of small molecule drug, SI-2, has potential for improving cancer treatment
Cancer cells communicate with their environment through cell molecules that pass on signals to the inside of the cell. SI-2 is a potent small-molecule inhibitor to drug the undruggable steroid receptor coactivator-3.

Contact: Maribel Mendoza
maribel.mendoza@bcm.edu
713-798-4710
Baylor College of Medicine

Public Release: 19-Apr-2016
Journal of Clinical Oncology
Breast cancer patients receiving Herceptin treatment should be monitored for heart damage at any age
Breast cancer patients undergoing treatment with trastuzumab-containing regimens should be monitored for heart damage regardless of age. This is among the findings of a new study from the Peter Munk Cardiac Centre, the Institute for Clinical Evaluative Sciences and the Ted Rogers Centre for Heart Research, University Health Network.

Contact: Lianne Castelino
lianne.castelino@uhn.ca
416-340-4429
University Health Network

Public Release: 19-Apr-2016
UTSW surgeons develop innovative technique for reconstructing breast after mastectomy
UT Southwestern Medical Center plastic surgeons have developed a new breast reconstruction technique that combines advantages of two different types of microsurgical procedures using abdominal and other tissue to reconstruct the breast after a mastectomy.

Contact: Gregg Shields
gregg.shields@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 19-Apr-2016
Annals of Surgical Oncology
Media coverage of celebrities with breast cancer influencing rise in double mastectomy
An increase in women with breast cancer choosing double mastectomy may be influenced by media coverage of celebrities, a new study finds.

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 19-Apr-2016
PLOS ONE
New technology quantifies effects of prostate tumor laser ablation
Researchers at Case Western Reserve University have developed computational tools to use magnetic resonance images to quantitatively evaluate the effects on the form and structure of the prostate following treatment. The image analysis may uncover risks of ablation and whether shape changes are associated with recurrence.
NIH/National Cancer Institute

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-534-7183
Case Western Reserve University

Showing releases 951-975 out of 1386.

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