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Public Release: 28-Jan-2016
Cell
New insights into PI3K pathway and cancer metabolism
New research led by scientists at Beth Israel Deaconess Medical Center (BIDMC) provides important insights into the biology that underlies glycolysis, the metabolic process that enables cancer cells to generate biomass and energy, confirming the importance of sugar to cancer survival.
NIH/National Cancer Institute, National Science Foundation, Stand Up 2 Cancer, Breast Cancer Research Foundation, Mary Kay Ash Foundation, Damon Runyon Cancer Research Foundation

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center

Public Release: 28-Jan-2016
Cell
TSRI study reveals workings of mysterious 'relief valve' that protects cells from swelling
Solving a long-standing mystery in cell biology, a team has shown how a key 'relief-valve' in cells keeps cells from taking in too much water and swelling excessively. The mechanism has been tentatively linked to stroke-induced brain damage, diabetes, immune deficiency and even cancer treatment resistance.
National Institutes of Health, Howard Hughes Medical Institute

Contact: Madeline McCurry-Schmidt
madms@scripps.edu
858-784-9254
Scripps Research Institute

Public Release: 28-Jan-2016
Science
A cancer's surprise origins, caught in action
Researchers at Boston Children's Hospital have, for the first time, visualized the origins of cancer from the first affected cell and watched its spread in a live animal.
National Institutes of Health, NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases, the Ellison Foundation, the Melanoma Research Alliance, the V Foundation and the Howard Hughes Medical Institute

Contact: Keri Stedman
keri.stedman@childrens.harvard.edu
617-919-3110
Boston Children's Hospital

Public Release: 28-Jan-2016
JAMA Oncology
Genetic sequencing can help guide treatment in children with solid tumors
Clinical genomic sequencing is feasible in pediatric oncology and can be used to recommend therapy or pinpoint diagnosis in children with solid tumors, according to the multi-center Individualized CAncer Therapy (iCat) study led by investigators from Dana-Farber/Boston Children's Cancer and Blood Disorders Center.
Hyundai Hope on Wheels, Friends for Life Foundation, Gillmore Fund

Contact: Anne Doerr
anne_doerr@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute

Public Release: 27-Jan-2016
Journal of the American College of Surgeons
Recommendation to omit radiation therapy after lumpectomy is not frequently implemented
Nearly two-thirds of US women age 70 or older with stage I breast cancer who undergo lumpectomy and are eligible to safely omit subsequent radiation therapy according to national cancer guidelines still receive this treatment, according to new study results.
LSU Health Sciences Center Charles Knight Sr. Endowed Professorship

Contact: Devin Rose
pressinquiry@facs.org
312-202-5324
American College of Surgeons

Public Release: 27-Jan-2016
Neuro-Oncology
UPMC-developed test rapidly, accurately profiles genetics and treatment of brain tumors
Brain tumors can be rapidly and accurately profiled with a next-generation, gene-sequencing test developed at UPMC and the University of Pittsburgh School of Medicine. The test, called GlioSeq, is now being used by UPMC oncologists to help guide treatment planning of brain cancers.
National Institutes of Health

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences

Public Release: 27-Jan-2016
Blood
Experts: High drug price trend has 'infected' generics
An article published online today in Blood, the Journal of the American Society of Hematology, suggests that pharmaceutical companies use several strategies to keep affordable generic drugs from the market, illustrating an emerging trend that authors say is becoming as harmful to consumers as high-cost brand-name drugs.

Contact: Amanda Szabo
aszabo@hematology.org
202-552-4914
American Society of Hematology

Public Release: 27-Jan-2016
Fred Hutch endorses HPV vaccination for cancer prevention
In response to low national vaccination rates for the human papillomavirus, or HPV, Fred Hutchinson Cancer Research Center has joined with the 68 other US National Cancer Institute-designated cancer centers in issuing a statement urging for increased vaccination in adolescent girls and boys for the prevention of many types of HPV-related cancers in adulthood.

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center

Public Release: 27-Jan-2016
Journal of Nuclear Medicine
A better way to image metastatic prostate cancer
A recent study, reported in the January issue of "The Journal of Nuclear Medicine," shows in a prospective, systematic manner that a PET/CT scan, using the radiotracer F-18-DCFBC to target prostate-specific membrane antigen (PSMA), is significantly more effective at detecting metastatic prostate cancer than conventional imaging methods.
Prostate Cancer Foundation--Young Investigator Award, RSNA Research & Education Foundation--Research Scholar Award

Contact: Laurie Callahan
lcallahan@snmmi.org
703-652-6773
Society of Nuclear Medicine

Public Release: 27-Jan-2016
Science of the Total Environment
Drugs and other contaminants found in private drinking wells on Cape Cod
In a new study, researchers found more than a dozen household chemicals in drinking water from private wells on Cape Cod. Backyard septic systems were identified as the likely source of contamination. Given that 44 million Americans rely on private wells and 25 percent of all American households have a septic system, the findings add to growing health concerns about unregulated chemicals in drinking water.

Contact: Alexandra Goho
goho@silentspring.org
617-332-4288 x232
Silent Spring Institute

Public Release: 27-Jan-2016
Cancer Chemotherapy and Pharmacology
Basic research led to first FDA-approved immunotherapy for pediatric cancer
Researchers at Children's Hospital Los Angeles have shown that an immunotherapy that until now has only been available to patients enrolled in research studies, is equivalent to the product that has been manufactured for commercial use and can be made available to all patients. The data, published in the journal Cancer Chemotherapy and Pharmacology on Jan. 20, was pivotal to the FDA approval of the first immunotherapy for the treatment of a pediatric cancer.

Contact: Ellin Kavanagh
ekavanagh@chla.usc.edu
323-361-8505
Children's Hospital Los Angeles

Public Release: 27-Jan-2016
Nature
Researchers mine the epigenome to identify likely origins of childhood brain tumor subtype
An international research team led by a St. Jude Children's Research Hospital scientist mined the epigenome to discover the likely cell of origin for Group 4 medulloblastoma, a key step in developing targeted therapies
German Cancer Aid, German Federal Ministry of Education and Research, German Cancer Research Center - Heidelberg Center for Personalized Oncology, CancerSys grant MYC-NET, Human Frontiers Science Program, US Department of Defense

Contact: Frannie Marmorstein
media@stjude.org
St. Jude Children's Research Hospital

Public Release: 26-Jan-2016
Annals of Oncology
Important falls in death rates from leukemia in Europe predicted for 2016
Death rates from leukemia among people of all ages in Europe are falling, according to the latest predictions for European cancer deaths in 2016, published in the leading cancer journal Annals of Oncology. The study by researchers in Italy, Switzerland and the USA looked at cancer death rates in the EU 28 member states as a whole and also in the six largest countries -- France, Germany, Italy, Poland, Spain and the UK -- for all cancers, and some individual cancers in men and women.
Italian Association for Cancer Research

Contact: Emma Mason
wordmason@mac.com
European Society for Medical Oncology

Public Release: 26-Jan-2016
CA: A Cancer Journal for Clinicians
Cancer in China
A new report estimates there were 4.3 million new cancer cases and more than 2.8 million cancer deaths in China in 2015, with lung cancer the most common cancer and the leading cause of cancer death in China.
American Cancer Society, National Health and Family Planning Commission of China, Ministry of Science and Technology

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society

Public Release: 26-Jan-2016
Oncotarget
DNA imprinting defects associated with childhood osteosarcoma development and progression
Children diagnosed with osteosarcoma may be impacted by a DNA imprinting defect also found in parents, according to new research from the Masonic Cancer Center, University of Minnesota. DNA imprinting is a phenomenon in which just one of the two inherited genes is active while the other is present but inactive. The study is published now in the journal Oncotarget.
American Cancer Society, Karen Wyckoff Sarcoma Foundation, Children's Cancer Research Fund, Sobiech Osteosarcoma Fund

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center

Public Release: 26-Jan-2016
Journal of Thoracic Oncology
Heavy smokers who quit more than 15 years ago still at high risk for lung cancer and should be screened
Expanding lung cancer screening to include people who quit smoking more than 15 years ago could detect more cases and further reduce associated mortality, according to a study by Mayo Clinic researchers published in the Journal of Thoracic Oncology.

Contact: Joe Dangor
newsbureau@mayo.edu
507-284-5005
Mayo Clinic

Public Release: 26-Jan-2016
2015 GPU Technology Conference
Titan targets tumors
Researchers at the German research laboratory Helmholtz-Zentrum Dresden Rossendorf are using Titan to understand and control new methods for particle acceleration that could have big impacts on laser-driven tumor removal.
Helmholtz-Zentrum Dresden-Rossendorf, US Department of Energy

Contact: Eric Gedenk
gedenked@ornl.gov
865-241-5497
DOE/Oak Ridge National Laboratory

Public Release: 26-Jan-2016
Journal of Clinical Oncology
For breast cancer patients, never too late to quit smoking
Documenting that it's never too late to quit smoking, a large study of breast cancer survivors has found that those who quit smoking after their diagnosis had a 33 percent lower risk of death as a result of breast cancer than those who continued to smoke.

Contact: Elizabeth Fernandez
elizabeth.fernandez@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 26-Jan-2016
American Journal of Cancer Research
Cancer riddle, solved
Using real-time recording of cellular movement, biologists at the University of Iowa have discovered how tumors form. Cancer cells extend cables and grab other cells. As little as five percent cancerous cells are needed for tumor formation. Findings could lead to more precise cancer testing. Results published in the journals PLoS One and American Journal of Cancer Research.
University of Iowa/The Developmental Studies Hybridoma Bank

Contact: Richard Lewis
richard-c-lewis@uiowa.edu
319-384-0012
University of Iowa

Public Release: 25-Jan-2016
Thyroid
Experts debate benefits and challenges of new ATA guidelines & differentiated thyroid cancer
In a stimulating new Roundtable Discussion, a distinguished panel of leading physicians and clinical researchers highlight the key changes, new topics, and areas of ongoing controversy in the "2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer." The Roundtable Discussion (http://register.liebertpub.com/thyroidroundtable/) and the ATA's 2015 Management Guidelines (http://online.liebertpub.com/doi/full/10.1089/thy.2015.0020) are available free to download on the website of Thyroid.

Contact: Kathryn Ryan
kryan@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 25-Jan-2016
eLife
Crouching protein, hidden enzyme
A new study led by scientists at The Scripps Research Institute (TSRI) and the University of California (UC), Berkeley shows how a crucial molecular enzyme starts in a tucked-in somersault position and flips out when it encounters the right target.
Damon Runyon Cancer Research Foundation, Pew Scholars program, NIH, Searle Scholars Program, NSF CAREER Program, HHMI and a NSF Foundation Graduate Research Fellowship

Contact: Madeline McCurry-Schmidt
madms@scripps.edu
858-784-9254
Scripps Research Institute

Public Release: 25-Jan-2016
Proceedings of the National Academy of Sciences
Scientists synthesize nanoparticles that can deliver tumor suppressors to damaged livers
UT Southwestern Medical Center chemists have successfully used synthetic nanoparticles to deliver tumor-suppressing therapies to diseased livers with cancer, an important hurdle scientists have been struggling to conquer.
Cancer Prevention and Research Institute of Texas, Welch Foundation, American Cancer Society, Mary Kay Foundation, Howard Hughes Medical Institute, Pollack Foundation, National Institutes of Health, Burroughs Wellcome Fund

Contact: Russell Rian
russell.rian@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 25-Jan-2016
Biomedical Optics Express
New pen-sized microscope could ID cancer cells in doctor's offices and operating rooms
University of Washington mechanical engineers have developed a handheld microscope to help doctors and dentists distinguish between healthy and cancerous cells in an office setting or operating room.
NIH/National Institute of Dental and Craniofacial Research, NIH/National Cancer Institute

Contact: Jennifer Langston
jlangst@uw.edu
206-543-2580
University of Washington

Public Release: 25-Jan-2016
Journal of Clinical Oncology
Targeted axillary dissection of lymph nodes after chemotherapy improves staging accuracy of node-positive breast cancer
A new procedure developed by surgeons at The University of Texas MD Anderson Cancer Center improves the accuracy of axillary staging and pathologic evaluation in clinically node-positive breast cancer, and reduces the need for a more invasive procedure with debilitating complications.

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center

Public Release: 25-Jan-2016
Journal of Thoracic Oncology
Afatinib shows clinical benefit for lung cancer patients with brain metastases
Non-small cell lung cancer (NSCLC) patients with common epidermal growth factor (EGFR) mutations and brain metastases showed improved progression-free survival (PFS) and response from the EGFR tyrosine kinase inhibitor (TKI) afatinib compared to standard platinum doublet chemotherapy.

Contact: Jeff Wolf
Jeff.Wolf@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer

Showing releases 951-975 out of 1339.

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