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Showing releases 951-975 out of 1333.

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Public Release: 26-Jan-2015
Journal of Cell Biology
Cells take sole responsibility for Merkel cell maintenance
Researchers have identified a population of 'progenitor' cells in the skin that are solely responsible for the generation and maintenance of touch-sensing Merkel cells.
National Institutes of Health, Richard King Mellon Foundation Institute for Pediatric Research

Contact: Rita Sullivan King
Rockefeller University Press

Public Release: 26-Jan-2015
Nature Chemical Biology
New strategy to combat 'undruggable' cancer molecule
Three of the four most fatal cancers are caused by a protein known as Ras; either because it mutates or simply because it ends up in the wrong place at the wrong time. Ras has proven an elusive target for scientist trying to cure the deadly diseases. Now a group from the Department of Chemistry, University of Copenhagen have discovered an unknown way for RAS to find its proper place in the cell. Their discovery may lead to completely novel approaches to curing cancer.

Contact: Jes Andersen
Faculty of Science - University of Copenhagen

Public Release: 26-Jan-2015
Proceedings of the National Academy of Sciences
Study reveals how a cancer-causing virus blocks human immune response
Scientists have revealed how a type of cancer-causing virus outwits the human body's immune response. The discovery might help explain why some cancer therapies that incorporate interferon fail to treat certain cancers and might lead to more effective treatments.
National Institutes of Health, Cancer Prevention and Research Institute of Texas

Contact: Marc Airhart
University of Texas at Austin

Public Release: 26-Jan-2015
Journal of Clinical Oncology
Care eliminates racial disparity in colon cancer survival rates, Stanford study finds
A study by researchers at the Stanford University School of Medicine shows that more equitable delivery of evidence-based care can close a persistent racial disparity in colon cancer survival rates in the United States.
Robert Wood Johnson Foundation

Contact: Krista Conger
Stanford University Medical Center

Public Release: 26-Jan-2015
Proceedings of the National Academy of Sciences
Cooperation between cancer cells makes therapies ineffective, suggests new treatment
New research from the University of East Anglia shows why many cancers are difficult to treat and come back following treatment. Scientists have shown that cancer cells cooperate with each other in the production of growth factors (molecules produced by the cancer cells that are essential for tumor progression). It is hoped that the findings will lead to a new type of treatment involving genetically modified cancer cells being reinserted into a tumor.
Natural Environment Research Council

Contact: Lisa Horton
University of East Anglia

Public Release: 26-Jan-2015
Many women with breast cancer have poor knowledge about their condition
A new analysis has found that many women with breast cancer lack knowledge about their illness, with minority patients less likely than white patients to know and report accurate information about their tumors' characteristics.

Contact: Evelyn Martinez

Public Release: 25-Jan-2015
British Journal of General Practice
Patients dismissing 'trivial' symptoms could delay cancer diagnosis
People who dismiss their symptoms as trivial or worry about wasting the doctor's time may decide against going to their GP with red-flag cancer warning symptoms, according to a Cancer Research UK study published in the British Journal of General Practice today.
Cancer Research UK

Contact: Sally Staples
Cancer Research UK

Public Release: 25-Jan-2015
ACS Nano
Promising use of nanodiamonds in delivering cancer drug to kill cancer stem cells
A study led by the National University of Singapore found that attaching chemotherapy drug Epirubicin to nanodiamonds effectively eliminates chemo-resistant cancer stem cells.

Contact: Kimberley Wang
National University of Singapore

Public Release: 23-Jan-2015
Journal of Proteomics and Bioinformatics
Researchers identify efficient methylating enzyme for cancer development
A recent study may help begin to explain how cancer develops though the abnormal turning on and off of genes. Researchers have discovered that the increase of methyl tags in cancer cells is due to highly efficient DNA methyl transferase 1 (DNMT1) enzymes found in these cells. The findings appear in the Journal of Proteomics and Bioinformatics.
American Cancer Society

Contact: Gina DiGravio
Boston University Medical Center

Public Release: 22-Jan-2015
British Journal of Clinical Pharmacology
Long-term use of hormonal contraceptives is associated with an increased risk of brain tumors
Taking a hormonal contraceptive for at least five years is associated with a possible increase in a young woman's risk of developing a rare tumor, glioma of the brain.

Contact: Evelyn Martinez

Public Release: 22-Jan-2015
American Journal of Transplantation
New machine-perfusion organ preservation system keeps livers healthier for transplant
A new preservation system that pumps cooled, oxygen-rich fluid into donor livers not only keeps the organs in excellent condition for as long as nine hours before transplantation, but also leads to dramatically better liver function and increases survival of recipients, according to animal studies conducted by researchers at the University of Pittsburgh School of Medicine and the McGowan Institute for Regenerative Medicine. The system could be tested with transplant patients at UPMC next year.
National Institutes of Health, Mr. and Mrs. Garcia de Souza

Contact: Anita Srikameswaran
University of Pittsburgh Schools of the Health Sciences

Public Release: 22-Jan-2015
Nature Communications
Major study links gene to drug resistance in testicular cancer
A major research study has uncovered several new genetic mutations that could drive testicular cancer -- and also identified a gene which may contribute to tumors becoming resistant to current treatments.
Movember Foundation

Contact: Claire Hastings
Institute of Cancer Research

Public Release: 22-Jan-2015
First major analysis of Human Protein Atlas is published in Science
A research article published today in Science presents the first major analysis based on the Human Protein Atlas, including a detailed picture of the proteins that are linked to cancer, the number of proteins present in the bloodstream, and the targets for all approved drugs on the market.

Contact: Mathias Uhlén
KTH, Royal Institute of Technology

Public Release: 22-Jan-2015
Nature Communications
Key factor discovered in the formation of metastases in melanoma
Melanoma, the most aggressive of all skin cancer strains, is often fatal for patients due to the pronounced formation of metastases. Until now, a melanoma's rampant growth was mainly attributed to genetic causes, such as mutations in certain genes. However, researchers from the University of Zurich now reveal that so-called epigenetic factors play a role in the formation of metastases in malignant skin cancer. This opens up new possibilities for future cancer treatments.

Contact: Lukas Sommer
University of Zurich

Public Release: 22-Jan-2015
Enzymes believed to promote cancer actually suppress tumors
Upending decades-old dogma, a team of scientists at the University of California, San Diego School of Medicine say enzymes long categorized as promoting cancer are, in fact, tumor suppressors and that current clinical efforts to develop inhibitor-based drugs should instead focus on restoring the enzymes' activities.
National Institutes of Health, James S. McDonnell Foundation, UCSD/Graduate Training Program in Cellular and Molecular Pharmacology, National Science Foundation/Graduate Research Fellowship, Cancer Research UK

Contact: Scott LaFee
University of California - San Diego

Public Release: 22-Jan-2015
Pacific Symposium on Biocomputing 2016
Noisy data facilitates Dartmouth investigation of breast cancer gene expression
Dartmouth researchers reported in Pacific Symposium on Biocomputing on the use of denoising autoencoders to effectively extract key biological principles from gene expression data and summarize them into constructed features with convenient properties.
National Institutes of Health, American Cancer Society

Contact: kirk Cassels
The Geisel School of Medicine at Dartmouth

Public Release: 22-Jan-2015
Cancer Research
New animal models faithfully reproduce the tumor of each patient
A team from the Catalan Institute of Oncology and Bellvitge Biomedical Research Institute has developed a new animal models that reproduce faithfully the evolution and malignancy of different human tumors. This facilitates parallel tumor progression in patients suffering from the disease in an animal laboratory mice in this case; and predict possible relapses and anticipate what will be most effective treatments.

Contact: Arantxa Mena
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 22-Jan-2015
Cell Reports
Angel or devil? For cancer, not all neutrophils are created equal
New research from the Hebrew University of Jerusalem shows that neutrophils, the most common form of white blood cells, contain many different subtypes. While some fight the development of cancer, others promote its progression. This distinction between harmful and helpful neutrophils opens up new diagnostic and therapeutic opportunities. Further research into the effects of boosting anti-tumor neutrophils and limiting tumor-promoting neutrophils may take us closer to developing effective new therapies for cancer.
Israeli Centers for Research Excellence Gene Regulation in Complex Human Disease, Abisch-Frenkel Foundation, Rosetrees Trust, Israel Cancer Research Foundation RCDA grant, CONCERN foundation, chief Scientist of the Israel Ministry of Health

Contact: Dov Smith
The Hebrew University of Jerusalem

Public Release: 22-Jan-2015
Pictured together for the first time: A chemokine and its receptor
Researchers at University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences and the Bridge Institute at the University of Southern California report the first crystal structure of the cellular receptor CXCR4 bound to an immune signaling protein called a chemokine. The structure, published Jan. 22 in Science, answers longstanding questions about a molecular interaction that plays an important role in human development, immune responses, cancer metastasis and HIV infections.
NIH/National Institute of General Medical Sciences, National Institutes of Health, Pharmaceutical Research and Manufacturers of America Foundation

Contact: Heather Buschman
University of California - San Diego

Public Release: 22-Jan-2015
International Journal of Epidemiology
Head and neck cancers in young adults are more likely to be a result of inherited factors
An article published online today in the International Journal of Epidemiology pools data from 25 case-control studies and conducts separate analyses to show that head and neck cancers in young adults are more likely to be as a result of inherited factors, rather than lifestyle factors such as smoking or drinking alcohol.

Contact: Katie Stileman
Oxford University Press

Public Release: 22-Jan-2015
Journal of Adolescent and Young Adult Oncology
Incidence of colorectal cancer increasing in young adults
The incidence of colorectal cancer among young adults ages 20-39 years has increased during the past 20-30 years, despite declining rates of CRC for the US population overall. This surprising new finding, an analysis of how CRC incidence varies based on race and gender, and differences in tumor location, for young adults compared to the general population are presented in the Journal of Adolescent and Young Adult Oncology.

Contact: Kathryn Ryan
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 21-Jan-2015
Nature Communications
Mutated ATRX gene linked to brain tumors potential biomarker for rare adrenal tumors too
For the first time, researchers at Penn's Abramson Cancer Center have found that a mutation in the ATRX may serve as a much-needed biomarker for the pheochromocytomas and paragangliomas that become malignant. These rare neuroendocrine tumors are typically benign, but when they go rogue, they become very aggressive.
PheoPara Alliance, The North American Neuroendocrine Tumor Society Early Career Development Award, National Center for Research Resources, National Center for Advancing Translational Sciences

Contact: Steve Graff
University of Pennsylvania School of Medicine

Public Release: 21-Jan-2015
Journal of Urology
Close monitoring of renal tumors may provide alternative to surgery
In patients likely to have surgery, close, active monitoring of small renal tumors confined to the kidneys is associated with low rates of tumor growth or death.

Contact: David Slotnick
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 21-Jan-2015
Molecular Cancer Research
Alternative DNA repair mechanism could provide better treatment for neuroblastoma in kids
Targeting DNA repair pathways could provide new treatment options for children with high-risk cancer.
Robert Wood Johnson Foundation/Amos Medical Faculty Development Program, The Alfred Taubman Medical Research Institute/Edith Briskin Emerging Scholar Program and the Section of Pediatric Surgery, The University of Michigan

Contact: Mary Masson
University of Michigan Health System

Public Release: 21-Jan-2015
NFCR-supported research finds new way to combat resistant cancers
A team of researchers at Massachusetts General Hospital has developed a new platform that can rapidly identify effective drug combinations for lung cancer patients whose tumors have stopped responding to targeted therapy. The research, which was supported in part by the National Foundation for Cancer Research, is a critical milestone on the road to personalized medicine.
National Foundation for Cancer Research

Contact: Adam Belmar
The Science Coalition

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