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Showing releases 951-975 out of 1246.

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Public Release: 3-Dec-2013
99th Radiological Society of North America Scientific Assembly and Annual Meeting
Breast tomosynthesis increases cancer detection and reduces recall rates
Researchers have found that digital breast tomosynthesis led to reduced recall rates and an increase in cancer detection in a large breast cancer screening program.

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America

Public Release: 3-Dec-2013
Cell Metabolism
Scientists discover new survival mechanism for stressed mitochondria
Scientists at The Scripps Research Institute (TSRI) have discovered a natural mechanism that cells use to protect mitochondria, the tiny but essential "power plants" that provide chemical energy for cells throughout the body. Damage to mitochondria is thought to be a significant factor in common neurodegenerative disorders, cancer and even the aging process. The TSRI researchers' discovery could lead to new methods for protecting mitochondria from such damage, thereby improving human health.
National Institutes of Health, Ellison Medical Foundation, Arlene and Arnold Goldstein

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute

Public Release: 3-Dec-2013
99th Radiological Society of North America Scientific Assembly and Annual Meeting
Breast cancer risk related to changes in breast density as women age
Automated breast density measurement is predictive of breast cancer risk in younger women, and that risk may be related to the rate at which breast density changes in some women as they age, according to new research.

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America

Public Release: 3-Dec-2013
99th Radiological Society of North America Scientific Assembly and Annual Meeting
3-D mammography increases cancer detection and reduces call-back rates, Penn study finds
Compared to traditional mammography, 3-D mammography -- known as digital breast tomosynthesis -- found 22 percent more breast cancers and led to fewer call backs in a large screening study at the Hospital of the University of Pennsylvania, researchers reported today at the annual meeting of the Radiological Society of North America.

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine

Public Release: 2-Dec-2013
Proceedings of the National Academy of Sciences
Burmese python genome reveals extreme adaptation
Scientists from the University of Colorado School of Medicine who sequenced the genome of the Burmese python have discovered large numbers of rapidly evolved genes in snakes.

Contact: david kelly
david.kelly@ucdenver.edu
303-503-7990
University of Colorado Denver

Public Release: 2-Dec-2013
Nature
The importance of standardizing drug screening studies
A bioinformatics expert at the IRCM, Benjamin Haibe-Kains, recently published an article stressing the importance of standardizing drug screening studies in the prestigious scientific journal Nature. The study supports the need for further development and standardization to improve the reproducibility of drug screening studies, as they are important in identifying new therapeutic agents and their potential combinations with existing drugs.

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal

Public Release: 2-Dec-2013
Journal of Clinical Investigation
JCI early table of contents for Dec. 2, 2013
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Dec. 2, 2013, in the JCI: "Predicting outcome for high-dose IL-2 therapy in cancer patients," "Blocking antioxidants in cancer cells reduces tumor growth in mice," "Platelets mediate lympho-venous hemostasis to maintain blood-lymphatic separation throughout life," "Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3-beta," "Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity," and more.

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 2-Dec-2013
Journal of Nuclear Medicine
Treatment plans for brain metastases more accurately determined with aid of molecular imaging trace
Imaging with the molecular imaging tracer 18F-FDOPA can help distinguish radiation-induced lesions from new tumor growth in patients who have been treated with radiation for brain metastases, according to new research published in The Journal of Nuclear Medicine. Using this amino acid tracer, researchers found that physicians could accurately differentiate the two types of lesions 83 percent of the time. Progression-free survival could also be predicted through evaluating the 18F-FDOPA imaging results.

Contact: Susan Martonik
smartonik@snmmi.org
703-652-6773
Society of Nuclear Medicine

Public Release: 2-Dec-2013
Journal of Clinical Investigation
Predicting outcome for high-dose IL-2 therapy in cancer patients
Previous studies indicate that regulatory T cell (Treg) populations increase in patients undergoing HD IL-2 therapy, and in this issue of the Journal of Clinical Investigation, Lazlo Radvanyi and colleagues at M.D. Anderson Cancer Center performed an in depth analysis of Treg populations in melanoma patients undergoing HD IL-2 therapy.
Prometheus Therapeutics and Diagnostics, Novartis, NIH/National Cancer Institute, Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 2-Dec-2013
Journal of Clinical Investigation
Blocking antioxidants in cancer cells reduces tumor growth in mice
In this issue of the Journal of Clinical Investigation, Navdeep Chandel and colleagues from Northwestern University report the effects of a SOD1 pharmacological inhibitor on non-small-cell lung cancer cells.
National Institutes of Health, LUNGevity Foundation, Consortium of Independent Lung Health Organizations

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 2-Dec-2013
PLOS ONE
Researchers turn to machines to identify breast cancer type
Team from University of Alberta and Alberta Health Services develop new technique to determine if tumours fed by estrogen.

Contact: Bryan Alary
bryan.alary@ualberta.ca
780-492-0436
University of Alberta

Public Release: 2-Dec-2013
PLOS ONE
HIV plus HPV leads to increased anal cancer risk in men
A study led by the UCLA School of Nursing found that men ages 40-69 who are having sex with other men, are HIV-infected and smoke are at a much higher risk of HPVs that most often cause anal cancer. This is the first large US study of a group of HIV-infected and uninfected men, over the age of 50. Many of these men were followed for more than 25 years.

Contact: Laura Perry
lperry@sonnet.ucla.edu
310-794-4022
University of California - Los Angeles

Public Release: 2-Dec-2013
Journal of National Cancer Institute
Genetic mutation may play key role in risk of lethal prostate cancer in overweight patients
Obesity is associated with a worse prostate cancer prognosis among men whose tumors contain a specific genetic mutation.
Dana-Farber/Harvard Cancer Center Specialized Programs of Research Excellence

Contact: Todd Datz
tdatz@hsph.harvard.edu
617-432-8413
Harvard School of Public Health

Public Release: 2-Dec-2013
Lancet Oncology
New drug cuts risk of deadly transplant side effect in half
A new class of drugs reduced the risk of patients contracting a serious and often deadly side effect of lifesaving bone marrow transplant treatments, according to a study from researchers at the University of Michigan Comprehensive Cancer Center.
Merck, Leukemia and Lymphoma Society, National Institutes of Health, St. Baldrick's Foundation

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 2-Dec-2013
Proceedings of the National Academy of Sciences
Difficult dance steps: Team learns how membrane transporter moves
Researchers have tried for decades to understand the undulations and gyrations that allow transport proteins to shuttle molecules from one side of a cell membrane to the other. Now scientists report that they have found a way to penetrate the mystery. They have worked out every step in the molecular dance that enables one such transporter to do its job.
National Institutes of Health

Contact: Diana Yates
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign

Public Release: 1-Dec-2013
Nature Medicine
Colon cancer researchers target stem cells, discover viable new therapeutic path
Scientists and surgeons at Princess Margaret Cancer Centre have discovered a promising new approach to treating colorectal cancer by disarming the gene that drives self-renewal in stem cells that are the root cause of disease, resistance to treatment and relapse. Colorectal cancer is the third leading cause of cancer-related death in the Western world.

Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network

Public Release: 30-Nov-2013
Nature
New family of proteins linked to major role in cancer
Scientists have described a new family of proteins that appear to play a key role in cancer and might be targets for future cancer drugs. A major new study in the journal Nature sets out the structure of the new family, called glutamate intramembrane proteases -- the founding member of which plays a critical role in transforming healthy cells into cancer cells.

Contact: Henry French
Henry.french@icr.ac.uk
020-715-35380
Institute of Cancer Research

Public Release: 29-Nov-2013
Nature Communications
Cyclin D1 governs microRNA processing in breast cancer
A protein that helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA, according to new research from Thomas Jefferson University.

Contact: Edyta Zielinska
edyta.zielinska@jefferson.edu
215-955-5291
Thomas Jefferson University

Public Release: 29-Nov-2013
ESTRO 33
Joint EORTC-ESTRO session to focus on current developments in soft tissue sarcoma treatment
The EORTC will host a joint session with ESTRO at ESTRO 33 focusing on current developments in soft tissue sarcoma treatment. It will take place from 14:30– 16:00 on Monday, 07 April 2014 in Vienna, Austria and will be co-chaired by Professors Jean-Yves Blay of the Centre Leon Berard in Lyon, France and past EORTC President and Philippe Maingon of the Centre Georges-François-Leclerc in Dijon, France, and Chair of the EORTC Radiation Oncology Group.

Contact: John Bean
john.bean@eortc.be
European Organisation for Research and Treatment of Cancer

Public Release: 28-Nov-2013
Biomedical Materials
Bone grafting improvements with the help of sea coral
Sea coral could soon be used more extensively in bone grafting procedures thanks to new research that has refined the material's properties and made it more compatible with natural bone.

Contact: Michael Bishop
michael.bishop@iop.org
01-179-301-032
Institute of Physics

Public Release: 28-Nov-2013
Science
High cholesterol fuels the growth and spread of breast cancer
A byproduct of cholesterol functions like the hormone estrogen to fuel the growth and spread of the most common types of breast cancers, researchers at the Duke Cancer Institute report.
National Institutes of Health

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

Public Release: 28-Nov-2013
Science Signaling
Methylation signaling controls angiogenesis and cancer growth
A study led by researchers at Boston University School of Medicine demonstrates a new mechanism involving a signaling protein and its receptor that may block the formation of new blood vessels and cancer growth. The findings are published in the December issue of Science Signaling.
National Institutes of Health, Massachusetts Lions Foundation

Contact: Jenny Eriksen
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center

Public Release: 28-Nov-2013
Science
Iron-based process promises greener, cheaper and safer drug and perfume production
University of Toronto researchers have developed a series of techniques to create a variety of very active iron-based catalysts necessary to produce the alcohols and amines used in the drug and perfume industry. The new synthetic methods promise to be safer and more economical and environmentally friendly than traditional industrial processes.
Natural Sciences and Engineering Research Council of Canada, GreenCentre Canada

Contact: Sean Bettam
s.bettam@utoronto.ca
416-946-7950
University of Toronto

Public Release: 28-Nov-2013
Journal of the National Cancer Institute
Why tumors become resistant to chemotherapy?
IDIBELL researchers describe one of the causes that make a patient with colon cancer that responds well to initial chemotherapy, becomes resistant when the tumor reappears. The results of the study have been published at the Journal of The National Cancer Institute.
European Community's Seventh Framework Programme

Contact: Arantxa Mena
amena@idibell.cat
34-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 28-Nov-2013
Nucleic Acids Research
CNIO scientists create the first large catalog of interactions between drugs and proteins
A Spanish National Cancer Research Centre work, led by Alfonso Valencia, Vice-Director of Basic Research, and Michael L. Tress, brings together the biggest collection of interactions between pharmacological molecules, including other compounds, and proteins. The catalog includes 16,600 compounds, of which 1,300 contain pharmacological descriptions, and 500,000 interactions that witness the extensive social network that governs the functioning of organisms. The information is available to the entire scientific community via the public FireDB database.

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Showing releases 951-975 out of 1246.

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