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Showing releases 951-975 out of 1176. << < 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 > >>
Public Release: 4-Feb-2013
 Annals of Internal MedicineAnnals of Internal Medicine tip sheet for Feb. 5, 2013 Below is information about articles being published in the February 5 issue of Annals of Internal Medicine. The information is not intended to substitute for the full articles as a source of information. Annals of Internal Medicine attribution is required for all coverage. Contact: Megan Hanks
Public Release: 3-Feb-2013
Nature Structural & Molecular BiologyChanges to DNA on-off switches affect cells' ability to repair breaks, respond to chemotherapy Penn cancer biologists have found a key determinant in the balance between two proteins, BRCA1 and 53BP1, in the DNA repair machinery. Breast and ovarian cancer are associated with a breakdown in the repair systems involving these proteins. Their findings appear in the latest online issue of Nature Structural & Molecular Biology. 
NIH/National Cancer Institute, American Cancer Society, US Department of Defense
Contact: Karen Kreeger
Public Release: 3-Feb-2013
Nature GeneticsResearchers discover mutations linked to relapse of childhood leukemia After an intensive three-year hunt through the genome, medical researchers have pinpointed mutations that leads to drug resistance and relapse in the most common type of childhood cancer -- the first time anyone has linked the disease's reemergence to specific genetic anomalies. Contact: Christopher Rucas
Public Release: 3-Feb-2013
Nature ImmunologyImmune cell 'survival' gene key to better myeloma treatments Scientists have identified the gene essential for survival of antibody-producing cells, a finding that could lead to better treatments for diseases where these cells are out of control, such as myeloma and chronic immune disorders. The discovery that a gene called Mcl-1 is critical for keeping this vital immune cell population alive was made by researchers at Melbourne's Walter and Eliza Hall Institute.
National Health and Medical Research Council of Australia, Multiple Myeloma Research Foundation, European Molecular Biology Organization, Victorian Government
Contact: Liz Williams
Public Release: 3-Feb-2013
Nature MedicineGrowth factor aids stem cell regeneration after radiation damage Epidermal growth factor has been found to speed the recovery of blood-making stem cells after exposure to radiation, according to Duke Medicine researchers. The finding could open new options for treating cancer patients and victims of dirty bombs or nuclear disasters.
National Institutes of Health, NIH/National Heart, Lung and Blood Institute, NIH/National Institute of Allergy and Infectious Diseases
Contact: Sarah Avery
Public Release: 2-Feb-2013
CellCaught in the act: Researchers capture key moments in cell death Scientists at the Walter and Eliza Hall Institute have for the first time visualized the molecular changes in a critical cell death protein that force cells to die.
NIH/National Health and Medical Research Council, Australian Research Council, Australian Cancer Research Foundation, Cancer Council Victoria, German Research Foundation, Leukemia & Lymphoma Society, Victorian Government
Contact: Vanessa Solomon
Public Release: 1-Feb-2013
Journal of Clinical InvestigationJCI early table of contents for Feb. 1, 2013 This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Feb. 1, 2013, in the JCI: A gut feeling about neural stem cells; A cellular adhesion protein protects against inflammation; and many more. Contact: Jillian Hurst
Public Release: 1-Feb-2013
Journal of the American College of RadiologyNovel radiation therapy method shortens prostate cancer treatment time According to a study in the Jan. issue of the Journal of the American College of Radiology, the use of volume-modulated arc therapy to deliver intensity-modulated radiation therapy to prostate cancer patients results in an overall reduction in treatment time of approximately 14 percent. Contact: Heather Curry
Public Release: 1-Feb-2013
Biophysical Society 57th Annual MeetingThe nanomechanical signature of breast cancer Differences in the stiffness of cancerous versus healthy tissue may aid in diagnosis and therapy, researchers say. The work will be presented at the 57th Annual Meeting of the Biophysical Society, held Feb. 2-6, 2013, in Philadelphia, Pa. Contact: Ellen R. Weiss
Public Release: 1-Feb-2013
Biophysical Society 57th Annual MeetingQuantum dots deliver Vitamin D to tumors for possible inflammatory breast cancer treatment Quantum dots can be used to rapidly move high concentrations of the active form of Vitamin D to targeted tumor sites where cancer cells accumulate. The research will be presented at the 57th Annual Meeting of the Biophysical Society, held Feb. 2-6, 2013, in Philadelphia, Pa. Contact: Ellen R. Weiss
Public Release: 1-Feb-2013
Journal of National Cancer InstituteMoffitt Cancer Center researchers develop automated breast density test linked to cancer risk Researchers at Moffitt Cancer Center and colleagues at the Mayo Clinic in Rochester, Minn., have developed a novel computer algorithm to easily quantify a major risk factor for breast cancer based on analysis of a screening mammogram.
NIH/National Cancer Institute, US Department of Defense
Contact: Kim Polacek
Public Release: 31-Jan-2013
ScienceTransition in cell type parallels treatment response, disease progression in breast cancer A process that normally occurs in developing embryos – the changing of one basic cell type into another – has also been suspected of playing a role in cancer metastasis. Now a study from Massachusetts General Hospital Cancer Center researchers has associated this process, called epithelial-mesenchymal transition or EMT, with disease progression and treatment response in breast cancer patients. The report also identifies underlying mechanisms that someday may become therapeutic targets.
National Institutes of Health, Stand Up to Cancer, Breast Cancer Research Foundation, Komen for the Cure
Contact: Katie Marquedant
Public Release: 31-Jan-2013
CellHow cancer cells rewire their metabolism to survive Many scientists have tried killing tumors by taking away their favorite food, a sugar called glucose. Unfortunately, this treatment approach not only fails to work, it backfires--glucose-starved tumors get more aggressive. In a study published January 31 in Cell, researchers at Sanford-Burnham Medical Research Institute discovered that the protein PKCz is responsible for this paradox. The research suggests that glucose depletion therapies might work, as long as the cancer cells produce PKCz.
National Institutes of Health
Contact: Heather Buschman
Public Release: 31-Jan-2013
ScienceUnderstanding 'master regulator' genes could lead to better cancer treatments A pair of genes work together as "master regulators" in cell division to keep the correct number of chromosomes in each daughter cell. Ipl1 and Mps1 work to hook and unhook chromosomes for proper DNA separation. The discovery could lead to better anti-cancer therapies.
National Science Foundation, NIH/National Institute of General Medical Sciences
Contact: Greg Elwell
Public Release: 31-Jan-2013
PLOS PathogensEngineered oncolytic herpes virus inhibits ovarian and breast cancer metastases A genetically reprogrammed Herpes simplex virus (HSV) can cure metastatic diffusion of human cancer cells in the abdomen of laboratory mice, according to a new study published January 31 in the Open Access journal PLOS Pathogens. The paper reports on the collaborative research from scientists at the at the University of Bologna and specifically describes that the HSV converted into a therapeutic anticancer agent attacks breast and ovarian cancer metastases. Contact: Gina Alvino
Public Release: 31-Jan-2013
Cell ReportsStudy finds hormones can change the breast's genetic material Melbourne scientists have discovered how female steroid hormones can make dramatic changes to the genetic material in breast cells, changes that could potentially lead to breast cancer. Researchers from the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, have identified how pregnancy hormones send signals to critical molecules on the DNA to make changes in the epigenome. The epigenome is a series of chemical tags that modify DNA, controlling which genes are switched on and off.
National Health and Medical Research Council of Australia, National Breast Cancer Foundation, ACRF
Contact: Liz Williams
Public Release: 31-Jan-2013
ScienceMutant gene gives pigeons fancy hairdos University of Utah researchers decoded the genetic blueprint of the rock pigeon, unlocking secrets about pigeons' Middle East origins, feral pigeons' kinship with escaped racing birds, and how mutations give pigeons traits like a fancy feather hairdo known as a head crest.
National Institutes of Health, Burroughs Wellcome Fund, National Science Foundation, University of Utah, Danish National Research Foundation
Contact: Lee J. Siegel
Public Release: 31-Jan-2013
Cancer CellBlood vessel cells coax colorectal cancer cells into more dangerous state Blood vessels that supply oxygen and nutrients to tumors can also deliver something else - a signal that strengthens nearby cancer cells, making them more resistant to chemotherapy, more likely to spread to other organs and more lethal, scientists at the University of Texas MD Anderson Cancer Center report online in Cancer Cell. Contact: Scott Merville
Public Release: 31-Jan-2013
OncoImmunology2-step immunotherapy attacks advanced ovarian cancer Most ovarian cancer patients are diagnosed with late stage disease that is unresponsive to existing therapies. In a new study, researchers from the Perelman School of Medicine at the University of Pennsylvania School of Medicine show that a two-step personalized immunotherapy treatment -- a dendritic cell vaccine using patients' own tumor followed by adoptive T cell therapy -- triggers anti-tumor immune responses in these type of patients. The investigators report on initial results of the approach this month in OncoImmunology.
NIH/National Cancer Institute, National Institutes of Health, Ovarian Cancer Immunotherapy Initiative
Contact: Holly Auer
Public Release: 31-Jan-2013
PLOS ONEUCSB anthropologists study effects of modernization on physical activity and heart disease Heart disease continues to be the leading cause of death in the United States, and a sedentary lifestyle is often cited as a major contributing factor. Among the Tsimane, an indigenous population in the lowlands of Bolivia's Amazon basin, however, indicators of heart disease are practically non-existent –– cholesterol is low, obesity is rare, and smoking is uncommon. Contact: Andrea Estrada
Public Release: 31-Jan-2013
Journal of Experimental Medicine1 of the key circuits in regulating genes involved in producing blood stem cells is deciphered Researchers from the group on stem cells and cancer at Hospital del Mar Medical Research Institute have deciphered one of the gene regulation circuits which would make it possible to generate hematopoietic blood cells, i.e. blood tissue stem cells. This could benefit patients with leukemia or other diseases requiring a transplant who do not have compatible donors. Contact: Marta Calsina
Public Release: 31-Jan-2013
CellA new mechanism that contributes to the evolution of cancer This study demonstrates the existence of new fragile genomic sites responsible for chromosomal alterations in tumors. This novel mechanism explains up to 50 percent of the abnormalities associated with some types of leukemia. Contact: Nuria Noriega
Public Release: 31-Jan-2013
Proceedings of the National Acadamy of SciencesHow the tilt of a cell-surface receptor prevents cancer Clear communication between cells is essential to every aspect of the body's internal function. But since cells can't talk, or send emails, how do they communicate? The answer, in a nutshell, is by dispatching signaling molecules that selectively bind to protein receptors on the outer surface of other cells with which they must "talk."
National Institutes of Health
Contact: Rachel Steinhardt
Public Release: 31-Jan-2013
Journal of Cancer SurvivorshipTime spent watching television is not associated with death among breast cancer survivors Spending a lot of time watching television after breast cancer diagnosis is not linked to death in these breast cancer survivors. It appears that after accounting for self-reported physical activity levels after diagnosis, sedentary behavior was not an independent risk factor for death. These findings by Stephanie George, from the National Cancer Institute, and her colleagues, are published online in Springer's Journal of Cancer Survivorship.
NIH/National Cancer Institute
Contact: Joan Robinson
Public Release: 30-Jan-2013
Nature CommunicationsUCI team finds new target for treating wide spectrum of cancers UC Irvine biologists, chemists and computer scientists have identified an elusive pocket on the surface of the p53 protein that can be targeted by cancer-fighting drugs. The finding heralds a new treatment approach, as mutant forms of this protein are implicated in nearly 40 percent of diagnosed cases of cancer, which kills more than half a million Americans each year.
NIH/National Cancer Institute, National Institutes of Health, National Science Foundation, UC Irvine
Contact: Tom Vasich
Showing releases 951-975 out of 1176. << < 34 | 35 | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 > >>
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