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Public Release: 26-Mar-2015
Clinical Gastroenterology and Hepatology
Female IBD patients: Stay up-to-date on your cervical cancer screening
Women with inflammatory bowel disease may be at increased risk of cervical dysplasia and cancer, according to a new study published in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association.

Contact: Rachel Steigerwald
media@gastro.org
301-272-1603
American Gastroenterological Association

Public Release: 26-Mar-2015
Cell Metabolism
The CNIO develops an anti-obesity treatment in animal models
The study has been conducted on obese mice and monkeys, using a drug which inhibits the activity of the PI3K enzyme. The body weight loss was exclusively due to a reduction in fat mass and no toxic effects have been noted. The study also found an improvement in the symptoms of diabetes and hepatic steatosis (fatty liver disease). Obesity is one of the top risk factors within the spectrum of serious diseases that constitute metabolic syndrome.

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 26-Mar-2015
Developmental Cell
Promising drug target identified in medulloblastoma
Scientists at Dana-Farber/Boston Children's Cancer and Blood Disorders Center have identified a protein critical to both the normal development of the brain and, in many cases, the development of medulloblastoma, a fast-growing brain tumor that usually strikes children under 10. As reported in Developmental Cell, when the researchers cut the level of the protein Eya1 in half in mice prone to develop medulloblastoma, the animals' risk of dying from the disease dropped dramatically.
National Institutes of Health, Pediatric Low-Grade Astrocytoma Foundation

Contact: Irene Sege
irene.sege@childrens.harvard.edu
617-919-3110
Dana-Farber Cancer Institute

Public Release: 26-Mar-2015
Cell Reports
New role uncovered for 'oldest' tumor suppressor gene
Scientists have revealed a brand new function for one of the first cancer genes ever discovered -- the retinoblastoma gene -- in a finding that could open up exciting new approaches to treatment. The retinoblastoma gene is defective in many cancers and is known to play a central role in stopping healthy cells from dividing uncontrollably. This study has found that the gene also has another important function, in helping to 'glue' severed strands of DNA back together.
Cancer Research UK, Worldwide Cancer Research, Wellcome Trust, The Institute of Cancer Research, UCL

Contact: Claire Hastings
chastings@icr.ac.uk
020-715-35380
Institute of Cancer Research

Public Release: 26-Mar-2015
JAMA Oncology
Fitness level associated with lower risk of some cancers, death in men
Men with a high fitness level in midlife appear to be at lower risk for lung and colorectal cancer, but not prostate cancer, and that higher fitness level also may put them at lower risk of death if they are diagnosed with cancer when they're older, according to a study published online by JAMA Oncology.

Contact: Sarah Keblin
sarah.keblin@med.uvm.edu
802-656-3099
The JAMA Network Journals

Public Release: 26-Mar-2015
Nature Communications
Blocking cellular quality control mechanism gives cancer chemotherapy a boost
Scientists have found a new way to make chemotherapy more effective against breast cancer cells. They show that blocking a cellular quality control mechanism before administering chemotherapy makes breast cancer cells die faster than when they were exposed to chemotherapy alone. The work is a long way from being applied in people, but it could lead to new treatment strategies for patients in the future.
NIH/National Institute for General Medical Sciences, University of Rochester Wilmot Cancer Institute, Damon Runyon Cancer Research Foundation

Contact: Emily Boynton
emily_boynton@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center

Public Release: 26-Mar-2015
EBioMedicine
Researcher overcomes radiation resistance in leukemia with an engineered precision medicine
A team of researchers led by Fatih M. Uckun, MD, PhD, of The Saban Research Institute of Children's Hospital Los Angeles and Professor at the University of Southern California Keck School of Medicine has determined that radiation resistance in leukemia can be overcome by using an engineered protein they recently designed and developed as a new precision medicine against leukemia.

Contact: Sacha Boucherie
s.boucherie@elsevier.com
31-204-853-564
Elsevier

Public Release: 26-Mar-2015
CA: A Cancer Journal for Clinicians
Prostate cancer and treatment choices -- a decision shared by doctor and patient?
Doctors strive to make treatment decisions together with their patients -- but is the decision really shared? According to adjunct professor Kari Tikkinen, shared decision-making isn't easy, and clinicians need help. The international research group led by Tikkinen has studied the decision aids for treatment choice of localized prostate cancer. The study was published in the CA: A Cancer Journal for Clinicians, which has the highest impact factor of any journal.

Contact: Kari Tikkinen
kari.tikkinen@gmail.com
358-505-250-971
University of Helsinki

Public Release: 25-Mar-2015
Science
Promising drug a 'new paradigm' for treating leukemia
Researchers at the University of Virginia School of Medicine have developed a compound that delays leukemia in mice and effectively kills leukemia cells in human tissue samples, raising hopes that the drug could lead to improved treatments in people. The researchers call it an exciting 'new paradigm' for treating leukemia.
NIH/National Cancer Institute, Leukemia & Lymphoma Society

Contact: Josh Barney
jdb9a@virginia.edu
434-906-8864
University of Virginia Health System

Public Release: 25-Mar-2015
Journal of the National Cancer Institute
Marine ϖ-3 polyunsaturated fatty acid intake is associated with lower risk of MSI-high CRC
High intake of marine ϖ-3 polyunsaturated fatty acids is associated with lower risk of microsatellite instable (MSI) colorectal cancers (CRCs) but not microsatellite stable CRCs, according to a new study published March 25 in the JNCI: Journal of the National Cancer Institute.

Contact: Zachary Rathner
Zachary.Rathner@oup.com
919-677-2697
Oxford University Press USA

Public Release: 25-Mar-2015
Clinical Colorectal Cancer
Blood test can help some bowel cancer patients avoid unnecessary drug side-effects
Manchester researchers have provided early evidence to suggest that a blood test could be used to identify bowel cancer patients that may benefit from more intensive chemotherapy.

Contact: Jamie Brown
Jamie.brown@manchester.ac.uk
44-016-127-58383
University of Manchester

Public Release: 25-Mar-2015
Nature Genetics
Like Angelina Jolie, study pinpoints genetic cause of increased leukemia risk
A University of Colorado Cancer Center study published today in the journal Nature Genetics describes a newly-discovered, heritable genetic cause of acute lymphoblastic leukemia, namely mutation of the gene ETV6.

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Anschutz Medical Campus

Public Release: 25-Mar-2015
2015 Symposium on Global Cancer Research
Global Oncology launches Global Cancer Project Map for cancer research access with NCI
Nonprofit Global Oncology, Inc. today announced the launch of the Global Cancer Project Map, a first-of-its-kind online resource and virtual information exchange for connecting the global cancer community. Developed by GO in collaboration with the National Cancer Institute Center for Global Health, the Map enables worldwide access to cancer projects and expertise to improve cancer practices and patient outcomes, especially in low-resource settings.

Contact: Danna Remen
danna@globalonc.org
617-504-4441
Global Oncology

Public Release: 25-Mar-2015
EMBO Reports
Control switch that modulates cell stress response may be key to multiple diseases
Researchers at the University of California, San Diego School of Medicine have discovered a control switch for the unfolded protein response, a cellular stress relief mechanism drawing major scientific interest because of its role in cancer, diabetes, inflammatory disorders and several neural degenerative disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
National Institutes of Health

Contact: Bonnie Ward
bjward@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 25-Mar-2015
Nature Biotechnology
Researchers discover genetic origins of myelodysplastic syndrome using stem cells
Induced pluripotent stem cells (iPSCs) -- adult cells reprogrammed back to an embryonic stem cell-like state -- may better model the genetic contributions patient's particular disease.
National Institutes of Health, American Society of Hematology, Sidney Kimmel Foundation for Cancer Research, Aplastic Anemia & MDS International Foundation, Ellison Medical Foundation, Damon Runyon Cancer Research Foundation, and others

Contact: Lucia Lee
lucia.lee@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine

Public Release: 25-Mar-2015
Toxicology in Vitro
Researchers solve science behind scalp cooling and the reasons for hair loss in cancer treatment
HAIR loss is one of the most distressing side-effects of cancer treatment and can even deter some patients from undergoing life-saving chemotherapy. But researchers at the University of Huddersfield are establishing the scientific basis for a rapidly-advancing scalp cooling technology that can ensure hair retention in a vast number of cases.

Contact: Nicola Werritt
n.c.werritt@hud.ac.uk
01-484-473-315
University of Huddersfield

Public Release: 24-Mar-2015
Breast Cancer Research and Treatment
Women with diabetes more likely to be diagnosed with advanced stage breast cancer
Diabetes is associated with more advanced stage breast cancer, according to a new study by the Institute for Clinical Evaluative Sciences and Women's College Hospital. The findings, published today in the journal Breast Cancer Research and Treatment, confirm a strong link between diabetes and later stage breast cancer at diagnosis for Canadian women.
Canadian Institutes for Health Research, Ontario Institute for Cancer Research

Contact: Diba Kohandani
diba.kohandani@wchospital.ca
416-323-6400 x3156
Women's College Hospital

Public Release: 24-Mar-2015
Gynecologic Oncology
Could a tampon one day help predict endometrial cancer? Mayo Clinic researchers say yes
Researchers at Mayo Clinic have shown that it is possible to detect endometrial cancer using tumor DNA picked up by ordinary tampons. The new approach specifically examines DNA samples from vaginal secretions for the presence of chemical 'off' switches -- known as methylation -- that can disable genes that normally keep cancer in check.
Mayo Clinic Specialized Program of Research Excellence (SPORE) in Ovarian Cancer from the National Institutes of Health, the Office of Women's Health Research Building Interdisciplinary Careers in Women's Health (BIRCWH), Mayo Clinic's NCI Cancer Center S

Contact: Joe Dangor
newsbureau@mayo.edu
507-284-5005
Mayo Clinic

Public Release: 24-Mar-2015
ChemMedChem
Brain tumor cells decimated by mitochondrial 'smart bomb'
An experimental drug that attacks brain tumor tissue by crippling the cells' energy source called the mitochondria has passed early tests in animal models and human tissue cultures, say Houston Methodist scientists.
Donna and Kenneth Peak Foundation, Houston Methodist Hospital/Kenneth Peak Brain and Pituitary Center, Taub Foundation, Pauline Sterne Wolff Memorial Foundation/Blanche Green Estate Fund, Verelan Foundation, and others

Contact: Gale Smith
gsmith@houstonmethodist.org
281-627-0439
Houston Methodist

Public Release: 24-Mar-2015
British Journal of Cancer
A cancer research breakthrough
Queen's University cancer researcher Madhuri Koti has discovered a biomarker that will help lead to better predictions of the success of chemotherapy in ovarian cancer patients. This discovery could lead to better treatment options in the fight against ovarian cancer.

Contact: Anne Craig
anne.craig@queensu.ca
613-533-2877
Queen's University

Public Release: 24-Mar-2015
Computational Biology
Why some HPV infections go away and others become cancer
A Duke study finds that the body's ability to clear an infection by the cancer-causing human papilloma virus (HPV) may be largely due to unpredictable division patterns in HPV-infected stem cells, rather than the strength of the person's immune response as previously thought.
National Institutes of Health

Contact: Robin Ann Smith
ras10@duke.edu
919-681-8057
Duke University

Public Release: 24-Mar-2015
Genome Biology
Singapore identifies mutations that may enable earlier diagnosis of colorectal cancer recurrence
A multi-disciplinary team of doctors and scientists from Singapore has characterised the genetic changes associated with the spread of colorectal cancer to the liver.

Contact: Rachel Tan
rachel.tan.c.h@nccs.com.sg
65-623-69535
SingHealth

Public Release: 24-Mar-2015
Gastroenterology
Patients with asymptomatic pancreatic cysts do not need constant surveillance
A new guideline from the American Gastroenterological Association (AGA) changes clinical practice by recommending longer surveillance periods for patients with asymptomatic pancreatic cysts and new criteria that limits surgery to those who will receive the most benefit.

Contact: Aimee Frank
media@gastro.org
301-941-2620
American Gastroenterological Association

Public Release: 24-Mar-2015
Technology
New technique paints tissue samples with light
One infrared scan can give pathologists a window into the structures and molecules inside tissues and cells, enabling fast and broad diagnostic assessments, thanks to an imaging technique developed by University of Illinois researchers and clinical partners. Using a combination of advanced microscope imaging and computer analysis, the new technique can give pathologists and researchers precise information without using chemical stains or dyes.
National Institutes of Health

Contact: Liz Ahlberg
eahlberg@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign

Public Release: 24-Mar-2015
Nature
Chemical tag marks future microRNAs for processing, study shows
By adding a chemical group to a particular sequence on RNA molecules, cells appear able to label the molecules that should be trimmed to make microRNAs. Because microRNAs help control processes throughout the body, this discovery has wide-ranging implications for development, health and disease, including cancer, the entry point for this research.

Contact: Wynne Parry
wparry@rockefeller.edu
212-327-7789
Rockefeller University

Showing releases 951-975 out of 1372.

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