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Public Release: 7-Aug-2014
Cancer Prevention Research
Gut microbiome analysis improved noninvasive colorectal cancer screening
Analysis of the gut microbiome more successfully distinguished healthy individuals from those with precancerous adenomatous polyps and those with invasive colorectal cancer compared with assessment of clinical risk factors and fecal occult blood testing, according to data published in Cancer Prevention Research, a journal of the American Association for Cancer Research.
National Institutes of Health

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 7-Aug-2014
Cell
Largest cancer genomic study proposes 'disruptive' new system to reclassify tumors
After analyzing more than 3,500 tumors on multiple technology platforms TCGA researchers say cancers are more likely to be similar based on their cell type of origin as opposed to their tissue type of origin. The study suggests at least 10 percent of cancer patients would be classified differently under this protocol. But Buck faculty Christopher Benz thinks this fraction will swell when more samples and additional tumor types are included in the next analysis.
NIH/National Cancer Institute, NIH/National Human Genome Research Institute

Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2080
Buck Institute for Age Research

Public Release: 7-Aug-2014
Cell
Cancer study reveals powerful new system for classifying tumors
Cancers are classified primarily on the basis of where in the body the disease originates, as in lung cancer or breast cancer. According to a new study, however, one in 10 cancer patients would be classified differently using a new classification system based on molecular subtypes instead of the current tissue-of-origin system. This reclassification could lead to different therapeutic options for those patients.
National Institutes of Health

Contact: Tim Stephens
stephens@ucsc.edu
831-459-2495
University of California - Santa Cruz

Public Release: 7-Aug-2014
Nature Communications
Cell mechanics may hold key to how cancer spreads and recurs
Cancer cells that break away from tumors to go looking for a new home may prefer to settle into a soft bed, according to new findings from researchers at the University of Illinois. Some particularly enterprising cancer cells can cause a cancer to spread to other organs or evade treatment to resurface after a patient is thought to be in remission. The researchers found that these tumor-repopulating cells may lurk quietly in stiffer cellular environments, but thrive in a softer space.
National Institutes of Health

Contact: Liz Ahlberg
eahlberg@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign

Public Release: 7-Aug-2014
Cell
Cancer categories recast in largest-ever genomic study
New research partly led by UC San Francisco-affiliated scientists suggests that one in 10 cancer patients would be more accurately diagnosed if their tumors were defined by cellular and molecular criteria rather than by the tissues in which they originated, and that this information, in turn, could lead to more appropriate treatments.

Contact: Peter Farley
peter.farley@ucsf.edu
415-502-6397
University of California - San Francisco

Public Release: 7-Aug-2014
Cell Reports
University of Minnesota research finds key piece to cancer cell survival puzzle
An international team led by Eric A. Hendrickson of the University of Minnesota and Duncan Baird of Cardiff University has solved a key mystery in cancer research: What allows some malignant cells to circumvent the normal process of cell death that occurs when chromosomes get too old to maintain themselves properly?

Contact: Stephanie Xenos
sxenos@umn.edu
612-624-8723
University of Minnesota

Public Release: 7-Aug-2014
Pancreatic survival rates at standstill for 4 decades
Long-term survival from pancreatic cancer has failed to improve in 40 years -- with the outlook remaining the lowest of the 21 most common cancers, according to new figures published by Cancer Research UK.

Contact: Ailsa Stevens
ailsa.stevens@cancer.org.uk
020-346-98309
Cancer Research UK

Public Release: 7-Aug-2014
Cell Reports
Scientists uncover key piece to cancer cell survival puzzle
A chance meeting between two leading UK and US scientists could have finally helped solve a key mystery in cancer research. Professor Duncan Baird and his team from Cardiff University, working in collaboration with Eric A. Hendrickson from the University of Minnesota, have identified a specific gene that human cells require in order to survive chromosomal defects.

Contact: Chris Jones
jonesc83@cardiff.ac.uk
029-208-74731
Cardiff University

Public Release: 7-Aug-2014
Cell Reports
Scientists uncover stem cell behavior of human bowel for the first time
For the first time, scientists have uncovered new information on how stem cells in the human bowel behave, revealing vital clues about the earliest stages in bowel cancer development and how we may begin to prevent it.

Contact: Charli Scouller
c.scouller@qmul.ac.uk
020-788-27943
Queen Mary, University of London

Public Release: 7-Aug-2014
Nature Communications
Mutations in a gene essential for cell regulation cause kidney cancer in children
Mutations in a gene that helps regulate when genes are switched on and off in cells have been found to cause rare cases of Wilms tumor, the most common kidney cancer occurring in children.
Wellcome Trust, Cancer Research UK

Contact: Henry French
henry.french@icr.ac.uk
020-715-35380
Institute of Cancer Research

Public Release: 6-Aug-2014
New England Journal of Medicine
Gene increases risk of breast cancer to 1 in 3 by age 70
Breast cancer risks for one of potentially the most important genes associated with breast cancer after the BRCA1/2 genes are today reported in the New England Journal of Medicine. Women with mutations in the PALB2 gene have on average a one in three chance of developing breast cancer by the age of 70.
European Research Council, Cancer Research UK

Contact: Craig Brierley
craig.brierley@admin.cam.ac.uk
44-012-237-66205
University of Cambridge

Public Release: 6-Aug-2014
Cancer Epidemiology, Biomarkers & Prevention
Nearly 10 percent of patients with cancer still smoke
Nine years after diagnosis, 9.3 percent of US cancer survivors were current smokers and 83 percent of these individuals were daily smokers who averaged 14.7 cigarettes per day, according to a report in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 6-Aug-2014
Cancer Epidemiology, Biomarkers & Prevention
Study: Many cancer survivors smoke years after diagnosis
Nearly one in 10 cancer survivors reports smoking many years after a diagnosis, according to a new study.
American Cancer Society

Contact: David Sampson
david.sampson@cancer.org
American Cancer Society

Public Release: 6-Aug-2014
Clinical Gastroenterology and Hepatology
Exposure to inflammatory bowel disease drugs could increase leukemia risk
Immunosuppressive drugs called thiopurines have been found to increase the risk of myeloid disorders, such as acute myeloid leukemia and myelodysplastic syndrome, a rare bone marrow disorder, seven-fold among inflammatory bowel disease patients.

Contact: Rachel Steigerwald
media@gastro.org
301-272-1603
American Gastroenterological Association

Public Release: 6-Aug-2014
Proceedings of the National Academy of Sciences
Discovery yields master regulator of toxin production in staph infections
St. Jude Children's Research Hospital scientists have discovered an enzyme that regulates production of the toxins that contribute to potentially life-threatening Staphylococcus aureus infections. The study recently appeared in the scientific journal the Proceedings of the National Academy of Sciences. Researchers also showed that the same enzyme allows Staphylococcus aureus to use fatty acids acquired from the infected individual to make the membrane that bacteria need to grow and flourish.
National Institutes of Health, NIH/National Cancer Institute, American Lebanese Syrian Associated Charities

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital

Public Release: 6-Aug-2014
Cell Transplantation
Researchers seek 'safety lock' against tumor growth after stem cell transplantation
Induced pluripotent stem cell-derived neural stem cells can promote functional recovery after spinal cord injury to laboratory animals; a drawback is their potential for tumorogenesis post-transplantation. To better understand this, researchers transplanted a human glioblastoma cell line into the intact spinal columns of laboratory mice that were either immunodeficient or immunocompetent, and treated with or without immunosuppressant drugs. They found that withdrawing immunosuppressant drugs eliminated tumor growth and created a 'safety lock' against tumor formation.
Japan Science and Technology, California Institute for Regenerative Medicine, Research Center Network for Realization of Regenerative Medicine, Centers for Clinical Application Research on Specific Disease/Organ

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair

Public Release: 6-Aug-2014
Nature
A new way to model cancer
New gene-editing technique from researchers at MIT allows scientists to more rapidly study the role of mutations in tumor development.
National Institutes of Health, NIH/National Cancer Institute

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology

Public Release: 6-Aug-2014
Cancer Research
Brain tumors fly under the body's radar like stealth jets, new U-M research suggests
Brain tumors fly under the radar of the body's defense forces by coating their cells with extra amounts of a specific protein, new research shows. Like a stealth fighter jet, the coating means the cells evade detection by the early-warning immune system that should detect and kill them. The stealth approach lets the tumors hide until it's too late for the body to defeat them.
NIH/National Institute of Neurological Disorders & Stroke

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 6-Aug-2014
Optics Letters
New hand-held device uses lasers, sound waves for deeper melanoma imaging
Melanoma is the deadliest form of skin cancer, causing more than 75 percent of skin-cancer deaths. The thicker the melanoma tumor, the more likely it will spread and the deadlier it becomes. Now, a team of researchers from Washington University in St. Louis have developed a new hand-held device that uses lasers and sound waves that may change the way doctors treat and diagnose melanoma. The tool is ready for commercialization and clinical trials.

Contact: Lyndsay Meyer
lmeyer@osa.org
202-416-1435
The Optical Society

Public Release: 5-Aug-2014
Annals of Oncology
Aspirin: Scientists believe cancer prevention benefits outweigh harms
New research from Queen Mary University of London reveals taking aspirin can significantly reduce the risk of developing -- and dying from -- the major cancers of the digestive tract, i.e. bowel, stomach and esophageal cancer.

Contact: Charli Scouller
c.scouller@qmul.ac.uk
020-788-27943
Queen Mary, University of London

Public Release: 5-Aug-2014
Review of Scientific Instruments
3-in-1 optical skin cancer probe
Researchers from the University of Texas at Austin's Cockrell School of Engineering have now developed a probe that combines into one device three unique ways of using light to measure the properties of skin tissue and detect cancer. The researchers have begun testing their 3-in-1 device in pilot clinical trials and are partnering with funding agencies and start-up companies to help bring the device to dermatologists' offices.

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
American Institute of Physics

Public Release: 5-Aug-2014
Gastroenterology
Genetic testing of tumor is recommended for colorectal cancer patients
Of the 143,000 patients diagnosed with colorectal cancer annually in the US, up to 25 percent have a familial risk of colorectal cancer. A new guideline from the US Multi-Society Task Force on Colorectal Cancer recommends genetic testing of tumors for all newly diagnosed colorectal cancer patients.

Contact: Aimee Frank
media@gastro.org
301-941-2620
American Gastroenterological Association

Public Release: 5-Aug-2014
Nucleic Acids Research
'Treatments waiting to be discovered' inside new database
A University of Colorado Cancer Center study recently published in the top-ranked journal Nucleic Acids Research describes a database named multiMiR, the most comprehensive database collecting information about microRNAs and their targets.
National Institutes of Health, NIH/National Cancer Institute

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

Public Release: 5-Aug-2014
American Journal of Respiratory and Critical Care Medicine
Cancer fighter can help battle pneumonia
The tip of an immune molecule known for its skill at fighting cancer may also help patients survive pneumonia, scientists report.
National Institutes of Health

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University

Public Release: 5-Aug-2014
Electronic cigarettes: Many questions, limited research
Electronic cigarettes are booming in popularity -- but there's still only limited evidence on their potential health risks, or their advertised benefits in helping people to quit smoking, according to a research review in the July/August Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health

Showing releases 951-975 out of 1248.

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