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Public Release: 3-Jul-2014
Cancer Cell
New study reveals how tumors remodel their surroundings to grow
Research identifies a mechanism in the tumor stroma that triggers an inflammatory response, promoting tumor growth and metastasis. The findings suggest a new approach to anti-cancer therapies that incorporates targets in the tumor microenvironment.

Contact: Susan Gammon
sgammon@sanfordburnham.org
858-795-5012
Sanford-Burnham Medical Research Institute

Public Release: 3-Jul-2014
Cell Stem Cell
Biochemical cascade causes bone marrow inflammation, leading to serious blood disorders
Like a line of falling dominos, a cascade of molecular events in the bone marrow produces high levels of inflammation that disrupt normal blood formation and lead to potentially deadly disorders including leukemia, an Indiana University-led research team has reported.
National Institutes of Health

Contact: Eric Schoch
eschoch@iu.edu
316-274-8205
Indiana University

Public Release: 3-Jul-2014
Human Molecular Genetics
A CNIO team reduces the size of the human genome to 19,000 genes
A study led by Alfonso Valencia and Michael Tress at the Spanish National Cancer Research Centre updates the number of human genes to 19,000; 1,700 fewer than the genes in the most recent annotation, and well below the initial estimations of 100,000 genes. The work, published in the journal Human Molecular Genetics, concludes that almost all of these genes have ancestors prior to the appearance of primates 50 million years ago.

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 3-Jul-2014
Angewandte Chemie
Safer, cheaper building blocks for future anti-HIV and cancer drugs
A team of researchers from KU Leuven, in Belgium, has developed an economical, reliable and heavy metal-free chemical reaction that yields fully functional 1,2,3-triazoles. Triazoles are chemical compounds that can be used as building blocks for more complex chemical compounds, including pharmaceutical drugs.

Contact: Wim Dehaen
wim.dehaen@chem.kuleuven.be
32-163-27439
KU Leuven

Public Release: 3-Jul-2014
Science
New discovery in living cell signaling
A breakthrough discovery into how living cells process and respond to chemical information could help advance the development of treatments for a large number of cancers and other cellular disorders that have been resistant to therapy.
National Institutes of Health

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory

Public Release: 3-Jul-2014
Cell
Sweet genes
A research team at the Faculty of Medicine & Dentistry at the University of Alberta have discovered a new way by which metabolism is linked to the regulation of DNA, the basis of our genetic code. The findings may have important implications for the understanding of many common diseases, including cancer.
Canadian Institutes for Health Research

Contact: Ross Neitz
rneitz@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry

Public Release: 2-Jul-2014
JAMA Surgery
Rapid surgical innovation puts patients at risk for medical errors
Researchers at the University of California, San Diego School of Medicine have found that the risk of patient harm increased two-fold in 2006 -- the peak year that teaching hospitals nationwide embraced the pursuit of minimally invasive robotic surgery for prostate cancer. Results of the study are published in the July 2 online issue of JAMA Surgery.

Contact: Jackie Carr
jcarr@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 2-Jul-2014
eLife
Upending a cancer dogma
Researchers at the University of California, San Diego School of Medicine say a protein essential to regulating cell cycle progression -- the process of cell division and replication -- activates a key tumor suppressor, rather than inactivating it as previously thought.

Contact: Jackie Carr
jcarr@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 2-Jul-2014
Experimental Cell Research
Stem cell type resists chemotherapy drug
In lab tests, Brown University researchers have found that adipose-derived stem cells, which can generate bone tissue, appear resistant to the toxicity of the chemotherapy drug methotrexate, which degrades bone in patients such as kids suffering from acute lymphoblastic leukemia. The newly published findings are preliminary but more tests are planned.
National Insitutes of Health, National Science Foundation

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

Public Release: 2-Jul-2014
PLOS ONE
Noninvasive advanced image analysis could lead to better patient care
Lung cancer patients could receive more precise treatment, and their progress could be better tracked, using a new high-tech method of non-invasive medical imaging analysis, according to a study published today by the journal PLOS ONE.
TGen Foundation, Scottsdale Healthcare Foundation, Flinn Foundation

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute

Public Release: 2-Jul-2014
Proceedings of the National Academy of Sciences
Purdue-designed tool helps guide brain cancer surgery
A tool to help brain surgeons test and more precisely remove cancerous tissue was successfully used during surgery. The mass spectrometry tool sprays a microscopic stream of charged solvent onto the tissue surface to gather information about its molecular makeup and produces a color-coded image that reveals the location, nature and concentration of tumor cells.
National Institutes of Health

Contact: Elizabeth K. Gardner
ekgardner@purdue.edu
765-494-2081
Purdue University

Public Release: 1-Jul-2014
Cancer Research
The inhibition of a protein opens the door to the treatment of pancreatic cancer
Researchers from IMIM have identified a new protein, galectin-1, as a possible therapeutic target for pancreatic cancer. For the first time they have demonstrated the effects of the inhibition of this protein in mice suffering this type of cancer and the results showed an increase in survival of 20%. The work further suggests that it could be a therapeutic target with no adverse effects.

Contact: Marta Calsina
mcalsina@imim.es
34-933-160-680
IMIM (Hospital del Mar Medical Research Institute)

Public Release: 1-Jul-2014
Nature Reviews Clinical Oncology
EORTC presents European solution for effective cancer drug development
In a paper published in Nature Reviews Clinical Oncology, the EORTC describes how collaborative molecular screening platforms can help researchers understand the biology of a cancer and support the design and conduct of subsequent confirmatory trials.

Contact: John Bean
john.bean@eortc.be
European Organisation for Research and Treatment of Cancer

Public Release: 1-Jul-2014
Journal of the National Cancer Institute
Medicare-backed breast cancer screenings skyrocket, but do patients benefit?
Breast cancer screening costs for Medicare patients skyrocketed between 2001 and 2009, but the increase did not lead to earlier detection of new breast cancer cases, according to a study published by Yale School of Medicine researchers in the July 1 Journal of the National Cancer Institute.
NIH/National Cancer Institute, P30 Cancer Center Support Grant

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University

Public Release: 1-Jul-2014
JAMA
Drug everolimus does not improve overall survival in patients with advanced liver cancer
Despite strong preclinical data, the drug everolimus failed to improve overall survival in patients with advanced liver cancer, compared to placebo, according to a study in the July 2 issue of JAMA.

Contact: Katie Marquedant
KMarquedant@mgh.harvard.edu
617-726-0337
The JAMA Network Journals

Public Release: 1-Jul-2014
Journal of the National Cancer Institute
Cancer risk: Aspirin and smoking affect aging of genes
The risk of developing cancer increases with age. Factors like smoking and regular aspirin use also affect the risk of cancer -- although in the opposite sense. Researchers from the University of Basel were now able to show that aspirin use and smoking both influence aging processes of the female genome that are connected to colorectal cancer. The Journal of the National Cancer Institute has published their results.

Contact: Olivia Poisson
olivia.poisson@unibas.ch
University of Basel

Public Release: 1-Jul-2014
Clinical Cancer Research
New approach identifies cancer mutations as targets of effective melanoma immunotherapy
A new approach demonstrated that the recognition of unique cancer mutations appeared to be responsible for complete cancer regressions in two metastatic melanoma patients treated with a type of immunotherapy called adoptive T-cell therapy. This new approach may help develop more effective cancer immunotherapies, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.
NIH/National Cancer Institute, Adelson Medical Research Foundation, Milstein Family Foundation, European Research Council

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research

Public Release: 1-Jul-2014
Journal of Behavioral Medicine
Fear, not data, motivates sunscreen users, research shows
We're often told that worrying can be harmful to one's health. But University at Buffalo researchers say that when it comes to preventing skin cancer, a little fear is good for you.

Contact: Marcene Robinson
marcener@buffalo.edu
716-645-4595
University at Buffalo

Public Release: 1-Jul-2014
Nature
For cancer patients, sugar-coated cells are deadly
Every living cell's surface has a protein-embedded membrane that's covered in polysaccharide chains -- a literal sugar coating. A new study by a Cornell University researcher found this coating is especially thick and pronounced on cancer cells and is a crucial determinant of the cell's survival. Consisting of long, sugar-decorated molecules called glycoproteins, the coating causes physical changes in the cell membrane that make the cell better able to thrive -- leading to a more lethal cancer.

Contact: Melissa Osgood
mmo59@cornell.edu
607-255-2059
Cornell University

Public Release: 1-Jul-2014
Oncotarget
Biomarker predicts effectiveness of brain cancer treatment
Researchers at the University of California, San Diego School of Medicine have identified a new biomarker that predicts whether glioblastoma -- the most common form of primary brain cancer -- will respond to chemotherapy. The findings are published in the July print issue of Oncotarget.
Sontag Foundation, Burroughs Wellcome Foundation, Kimmel Foundation, Forbeck Foundation

Contact: Jackie Carr
jcarr@ucsd.edu
619-543-6163
University of California - San Diego

Public Release: 1-Jul-2014
EMBO Journal
Enlightening cancer cells
Joint EMBO Journal paper by IST Austria and Vienna Medical University groups on engineered cell surface receptors activated by light. Small algal protein domains serve as synthetic light sensors in human cells. First application of optogenetics to cancer research.

Contact: Oliver Lehmann
oliver.lehmann@ist.ac.at
43-067-640-12562
Institute of Science and Technology Austria

Public Release: 1-Jul-2014
Lancet Oncology
Mayo Clinic: Proton therapy has advantages over IMRT for advanced head and neck cancers
A new study by radiation oncologists at Mayo Clinic comparing the world's literature on outcomes of proton beam therapy in the treatment of a variety of advanced head and neck cancers of the skull base compared to intensity modulated radiation therapy (IMRT) has found that proton beam therapy significantly improved disease free survival and tumor control when compared to IMRT. The results appear in the journal Lancet Oncology.
Mayo Foundation for Medical Education and Research

Contact: Joe Dangor
newsbureau@mayo.edu
507-284-5005
Mayo Clinic

Public Release: 1-Jul-2014
American Journal of Physiology - Gastrointestinal and Liver Physiology
Chinese herbal extract may help kill off pancreatic cancer cells
In research appearing in AJP Gastrointestinal and Liver Physiology, University of Minnesota researchers find an ancient Chinese herb decreases a protective protein that helps cells survive allowing cell death in pancreatic cancer cells. The article is highlighted as part of the APSselect program.

Contact: Stacy Brooks
sbrooks@the-aps.org
301-634-7209
American Physiological Society

Public Release: 1-Jul-2014
Oncotarget
Mayo Clinic researchers reveal treasure trove of genes key to kidney cancer
A genomic analysis of clear cell renal cell carcinoma, the most common form of kidney cancer, from 72 patients has uncovered 31 genes that are key to development, growth and spread of the cancer, say researchers from Mayo Clinic in Florida.
NIH/National Cancer Institute

Contact: Kevin Punsky
904-953-0746
Mayo Clinic

Public Release: 30-Jun-2014
Annals of Internal Medicine
New research study shows huge savings for health care
Recently published findings in Annals of Internal Medicine by Steven Lipshultz, M.D., Wayne State University professor and chair of pediatrics and pediatrician-in-chief at the Children's Hospital of Michigan, part of the Detroit Medical Center, and colleagues could help to reduce health care charges while also protecting childhood cancer survivors from heart ailments caused by drug therapy.
Lance Armstrong Foundation, NIH/National Cancer Institute

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research

Showing releases 951-975 out of 1285.

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