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Showing releases 976-1000 out of 1235.

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Public Release: 29-Apr-2014
Genome Research
Immunogenic mutations in tumor genomes correlate with increased patient survival
Developing immunotherapies for cancer is challenging because of significant variability among tumors and diversity in human immune types. In a study published online today in Genome Research, researchers examined the largest collection of tumor samples to date to predict patient-specific tumor mutations that may activate the patient's immune system, paving the way for more successful, personalized cancer immunotherapy.
BC Cancer Foundation, Canadian Institutes of Health Research, US Department of Defense

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory

Public Release: 29-Apr-2014
Gastroenterology
Microfluidic technology reveals potential biomarker for early pancreatic cancer
The findings, published in Gastroenterology, revealed circulating pancreas cells seed the bloodstream before tumors can be detected using current clinical tests. The data suggest that the detection of pancreas cells in the blood may be an early sign of cancer.
Naitonal Institutes of Health

Contact: Shantell M. Kirkendoll
smkirk@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 29-Apr-2014
94th AATS Annual Meeting
Poor QOL doesn't predict low survival in high-risk lung cancer patients undergoing surgery
High-risk operable lung cancer patients have poorer quality of life scores than the normal US population. However surgery can still be undertaken safely: Low global quality of life scores were not associated with lower survival, recurrence-free rate, or for higher risk for adverse events following sublobar resection, a major surgical procedure.

Contact: Nicole Baritot
press@aats.org
978-299-4520
American Association for Thoracic Surgery

Public Release: 29-Apr-2014
94th AATS Annual Meeting
Major lung resection safer than ever, especially at the busiest hospitals
A major new study using data from the National Cancer Data Base details the impact of annual hospital volume on 30- and 90-day mortality rates. Investigators found that major lung surgery has become progressively safer over the last few decades, although higher death rates at low-volume hospitals and an unexpected increase in mortality at 90 days compared to 30 days were observed. The study further suggests that choosing a center that performs major lung surgery regularly can have a strong impact on survival.

Contact: Nicole Baritot
press@aats.org
978-299-4520
American Association for Thoracic Surgery

Public Release: 29-Apr-2014
Journal of Clinical Endocrinology and Metabolism
Vitamin D may raise survival rates among cancer patients
Cancer patients who have higher levels of vitamin D when they are diagnosed tend to have better survival rates and remain in remission longer than patients who are vitamin D-deficient, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Contact: Jenni Glenn Gingery
jgingery@endocrine.org
202-971-3655
The Endocrine Society

Public Release: 29-Apr-2014
94th AATS Annual Meeting
Breath analysis offers non-invasive method to detect early lung cancer
Researchers at the University of Louisville School of Medicine are using breath analysis to detect the presence of lung cancer. Preliminary data indicate that this promising noninvasive tool offers the sensitivity of PET scanning, and has almost twice the specificity of PET for distinguishing patients with benign lung disease from those with early stage cancer. Michael Bousamra II, M.D., Associate Professor, Department of Cardiovascular and Thoracic Surgery, is presenting the results of the study at the AATS 2014 Conference on Apr. 29, 2014.

Contact: Nicole Baritot
press@aats.org
978-299-4520
American Association for Thoracic Surgery

Public Release: 28-Apr-2014
Nature Genetics
Loss of Y chromosome can explain shorter life expectancy and higher cancer risk for men
It is generally well known that men have an overall shorter life expectancy compared to women. A recent study, led by Uppsala University researchers, shows a correlation between a loss of the Y chromosome in blood cells and both a shorter life span and higher mortality from cancer in other organs.

Contact: Jan Dumanski
jan.dumanski@igp.uu.se
46-018-471-5035
Uppsala University

Public Release: 28-Apr-2014
Cancer
Unemployment common after breast cancer treatment
Nearly one-third of breast cancer survivors who were working when they began treatment were unemployed four years later. Women who received chemotherapy were most affected, according to a new study from the University of Michigan Comprehensive Cancer Center.
NIH/National Cancer Institute, American Cancer Society

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 28-Apr-2014
Nature Reviews Cancer
Imaging gives clearer picture of cancer drugs' chances of success
The quest for new cancer treatments could be revolutionized by advances in technology that can visualize living cells and tissues, scientists claim.

Contact: Jen Middleton
jen.middleton@ed.ac.uk
44-131-650-6514
University of Edinburgh

Public Release: 28-Apr-2014
Cancer
Receiving chemotherapy after a breast cancer diagnosis may affect a patient's employment
A new study has found that loss of paid employment after a diagnosis of early-stage breast cancer may be common and potentially related to the type of treatment patients received.

Contact: Evelyn Martinez
sciencenewsroom@wiley.com
Wiley

Public Release: 28-Apr-2014
Chromatographia
Two breath compounds could be associated with larynx cancer
Researchers at the Rey Juan Carlos University and the Alcorcon Hospital (Madrid) have compared the volatile substances exhaled by eleven people with cancer of larynx, with those of another twenty healthy people. The results show that the concentrations of certain molecules, mainly ethanol and 2-butanone, are higher in individuals with carcinoma, therefore they act as potential markers of the disease.

Contact: SINC
info@agenciasinc.es
34-914-251-820
FECYT - Spanish Foundation for Science and Technology

Public Release: 28-Apr-2014
Pediatrics
Well-informed patients key to accepting gene-based drug dosing
A new study out of Western University led by Dr. Michael Rieder, illustrates the need for a lot more education around pharmacogenetics -- the study of how a patient's genes can affect drug reaction and dosage. Pharmacogenetics promises to optimize patient response to therapy, but this is the first study to really investigate how patients perceive this kind of genetic testing, and whether those perceptions differ when it comes to parents and their children.
Schulich School of Medicine & Dentistry, Western University

Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario

Public Release: 28-Apr-2014
European Journal of Immunology
One cell type may quash tumor vaccines
Researchers suspect that many cancer vaccines fail because the immune cells that would destroy the tumor are actively suppressed. Now, researchers at Thomas Jefferson University have found that a single cell type may be to blame for the suppression, paving the way to better cancer vaccine design.

Contact: Edyta Zielinska
edyta.zielinska@jefferson.edu
215-955-5291
Thomas Jefferson University

Public Release: 28-Apr-2014
Current Oncology
Breast cancer patients place huge emphasis on gene expression profiling test
Gene expression profiling tests play a critical role when women with early-stage breast cancer decide whether to have chemotherapy, but many of them do not fully understand what some of the test results mean, new research suggests.
Cancer Care Ontario, Ontario Institute for Cancer Research

Contact: Leslie Shepherd
shepherdl@smh.ca
416-864-6094
St. Michael's Hospital

Public Release: 28-Apr-2014
Nature
Researchers identify mechanism of cancer caused by loss of BRCA1 and BRCA2 gene function
Inherited mutations in the BRCA1 or BRCA2 tumor suppressor genes are by far the most frequent contributors of hereditary cancer risk in the human population, often causing breast or ovarian cancer in young women of child-bearing age. Now investigators at Beth Israel Deaconess Medical Center report a new mechanism by which BRCA gene loss may accelerate cancer-promoting chromosome rearrangements.
National Institutes of Health, American Cancer Society

Contact: Bonnie Prescott
bprescot@bidcm.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center

Public Release: 28-Apr-2014
Journal of Biological Chemistry
Researchers identify potential new strategy to treat ovarian cancer
Scientists studying cancerous tumor tissues in a laboratory believe they have identified a potential new strategy to treat ovarian cancer -- which affects around 7,000 women in the UK each year.

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester

Public Release: 25-Apr-2014
eLife
A civil war inside our cells: Scientists show how our bodies fight off 'jumping genes'
There's a civil war going on inside every one of the 37 trillion cells in your body. Now, University of Michigan scientists have uncovered how your cells keep this war from causing too much collateral damage.
Howard Hughes Medical Institute

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System

Public Release: 25-Apr-2014
Biofabrication
3-D printing cancer tumors
Wei Sun, Ph.D., a mechanical engineering researcher at Drexel University, has devised a method for 3-D printing tumors that could soon be taking cancer research out of the petri dish.
National Science Foundation

Contact: Britt Faulstick
bef29@drexel.edu
215-895-2617
Drexel University

Public Release: 25-Apr-2014
Journal of Clinical Investigation
Researchers generate immunity against tumor vessel protein
A group of researchers from the Abramson Cancer Center and the Perelman School of Medicine at the University of Pennsylvania is employing a novel DNA vaccine to kill cancer, not by attacking tumor cells, but targeting the blood vessels that keep them alive. The vaccine also indirectly creates an immune response to the tumor itself, amplifying the attack by a phenomenon called epitope spreading. The results of the study were published this month in the Journal of Clinical Investigation.
Pennsylvania Department of Health

Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-776-6063
University of Pennsylvania School of Medicine

Public Release: 24-Apr-2014
Chemistry & Biology
Large-scale identification and analysis of suppressive drug interactions
Cell analysis finds drug interactions to be startlingly common: baker's yeast is giving scientists a better understanding of drug interactions, which are a major cause of illness and hospitalization worldwide.

Contact: Polly Thompson
pthompson@lunenfeld.ca
416-586-4800 x2046
Lunenfeld-Tanenbaum Research Institute

Public Release: 24-Apr-2014
Blood
Moffitt Cancer Center's phase 3 study may be game-changer for acute myeloid leukemia
Moffitt Cancer Center researchers say clinical trials for a new experimental drug to treat acute myeloid leukemia are very promising. Patients treated with CPX-351, a combination of the chemotherapeutic drugs cytarabine and daunorubicin, are showing better responses than patients treated with the standard drug formulation.
Celator Pharmaceuticals

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 24-Apr-2014
Journal of Pathology
Finnish team of researchers finds a mutation in a tumor of the jaw
A Finnish team of researchers was the first in the world to discover a gene mutation in ameloblastoma, which is a tumor of the jaw. Researchers have been searching for the mutation that causes ameloblastoma for decades, and this mutation has now been found in a patient living in the eastern part of Finland.

Contact: Kristiina Heikinheimo
krihei@uef.fi
358-505-642-669
University of Eastern Finland

Public Release: 24-Apr-2014
International Journal of Cancer
Breast cancer replicates brain development process
New research led by a scientist at the University of York reveals that a process that forms a key element in the development of the nervous system may also play a pivotal role in the spread of breast cancer.
United Kingdom Medical Research Council

Contact: David Garner
david.garner@york.ac.uk
44-019-043-22153
University of York

Public Release: 24-Apr-2014
Journal of Clinical Investigation
JCI online ahead of print table of contents for April 24, 2014
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers published online, April 24, 2014, in the JCI: 'Ex vivo expansion of hematopoietic stem cells from cord blood,' 'Receptors in the brain mediate the weight loss effects of GLP1 agonists,' 'Peripheral nervous system plasmalogens regulate Schwann cell differentiation and myelination,' 'Estrogen promotes Leydig cell engulfment by macrophages in male infertility,' and more.

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 24-Apr-2014
Neoplasia
New study helps to explain why breast cancer often spreads to the lung
New research led by Alison Allan, Ph.D., a scientist at Western University and the Lawson Health Research Institute, shows why breast cancer often spreads or metastasizes to the lung. The breast cancer stem cell (CSC) has been shown to be responsible for metastasis in animal models, particularly to the lung. And this new research found CSCs have a particular propensity for migrating towards and growing in the lung because of certain proteins found there.
Canadian Breast Cancer Foundation-Ontario Region

Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario

Showing releases 976-1000 out of 1235.

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