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Showing releases 976-1000 out of 1284.

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Public Release: 1-Jul-2014
Cancer Research
The inhibition of a protein opens the door to the treatment of pancreatic cancer
Researchers from IMIM have identified a new protein, galectin-1, as a possible therapeutic target for pancreatic cancer. For the first time they have demonstrated the effects of the inhibition of this protein in mice suffering this type of cancer and the results showed an increase in survival of 20%. The work further suggests that it could be a therapeutic target with no adverse effects.

Contact: Marta Calsina
IMIM (Hospital del Mar Medical Research Institute)

Public Release: 1-Jul-2014
Nature Reviews Clinical Oncology
EORTC presents European solution for effective cancer drug development
In a paper published in Nature Reviews Clinical Oncology, the EORTC describes how collaborative molecular screening platforms can help researchers understand the biology of a cancer and support the design and conduct of subsequent confirmatory trials.

Contact: John Bean
European Organisation for Research and Treatment of Cancer

Public Release: 1-Jul-2014
Journal of the National Cancer Institute
Medicare-backed breast cancer screenings skyrocket, but do patients benefit?
Breast cancer screening costs for Medicare patients skyrocketed between 2001 and 2009, but the increase did not lead to earlier detection of new breast cancer cases, according to a study published by Yale School of Medicine researchers in the July 1 Journal of the National Cancer Institute.
NIH/National Cancer Institute, P30 Cancer Center Support Grant

Contact: Karen N. Peart
Yale University

Public Release: 1-Jul-2014
Drug everolimus does not improve overall survival in patients with advanced liver cancer
Despite strong preclinical data, the drug everolimus failed to improve overall survival in patients with advanced liver cancer, compared to placebo, according to a study in the July 2 issue of JAMA.

Contact: Katie Marquedant
The JAMA Network Journals

Public Release: 1-Jul-2014
Biomarker predicts effectiveness of brain cancer treatment
Researchers at the University of California, San Diego School of Medicine have identified a new biomarker that predicts whether glioblastoma -- the most common form of primary brain cancer -- will respond to chemotherapy. The findings are published in the July print issue of Oncotarget.
Sontag Foundation, Burroughs Wellcome Foundation, Kimmel Foundation, Forbeck Foundation

Contact: Jackie Carr
University of California - San Diego

Public Release: 1-Jul-2014
Journal of the National Cancer Institute
Cancer risk: Aspirin and smoking affect aging of genes
The risk of developing cancer increases with age. Factors like smoking and regular aspirin use also affect the risk of cancer -- although in the opposite sense. Researchers from the University of Basel were now able to show that aspirin use and smoking both influence aging processes of the female genome that are connected to colorectal cancer. The Journal of the National Cancer Institute has published their results.

Contact: Olivia Poisson
University of Basel

Public Release: 1-Jul-2014
Clinical Cancer Research
New approach identifies cancer mutations as targets of effective melanoma immunotherapy
A new approach demonstrated that the recognition of unique cancer mutations appeared to be responsible for complete cancer regressions in two metastatic melanoma patients treated with a type of immunotherapy called adoptive T-cell therapy. This new approach may help develop more effective cancer immunotherapies, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.
NIH/National Cancer Institute, Adelson Medical Research Foundation, Milstein Family Foundation, European Research Council

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 1-Jul-2014
For cancer patients, sugar-coated cells are deadly
Every living cell's surface has a protein-embedded membrane that's covered in polysaccharide chains -- a literal sugar coating. A new study by a Cornell University researcher found this coating is especially thick and pronounced on cancer cells and is a crucial determinant of the cell's survival. Consisting of long, sugar-decorated molecules called glycoproteins, the coating causes physical changes in the cell membrane that make the cell better able to thrive -- leading to a more lethal cancer.

Contact: Melissa Osgood
Cornell University

Public Release: 1-Jul-2014
EMBO Journal
Enlightening cancer cells
Joint EMBO Journal paper by IST Austria and Vienna Medical University groups on engineered cell surface receptors activated by light. Small algal protein domains serve as synthetic light sensors in human cells. First application of optogenetics to cancer research.

Contact: Oliver Lehmann
Institute of Science and Technology Austria

Public Release: 1-Jul-2014
Lancet Oncology
Mayo Clinic: Proton therapy has advantages over IMRT for advanced head and neck cancers
A new study by radiation oncologists at Mayo Clinic comparing the world's literature on outcomes of proton beam therapy in the treatment of a variety of advanced head and neck cancers of the skull base compared to intensity modulated radiation therapy (IMRT) has found that proton beam therapy significantly improved disease free survival and tumor control when compared to IMRT. The results appear in the journal Lancet Oncology.
Mayo Foundation for Medical Education and Research

Contact: Joe Dangor
Mayo Clinic

Public Release: 1-Jul-2014
Journal of Behavioral Medicine
Fear, not data, motivates sunscreen users, research shows
We're often told that worrying can be harmful to one's health. But University at Buffalo researchers say that when it comes to preventing skin cancer, a little fear is good for you.

Contact: Marcene Robinson
University at Buffalo

Public Release: 1-Jul-2014
Mayo Clinic researchers reveal treasure trove of genes key to kidney cancer
A genomic analysis of clear cell renal cell carcinoma, the most common form of kidney cancer, from 72 patients has uncovered 31 genes that are key to development, growth and spread of the cancer, say researchers from Mayo Clinic in Florida.
NIH/National Cancer Institute

Contact: Kevin Punsky
Mayo Clinic

Public Release: 1-Jul-2014
American Journal of Physiology - Gastrointestinal and Liver Physiology
Chinese herbal extract may help kill off pancreatic cancer cells
In research appearing in AJP Gastrointestinal and Liver Physiology, University of Minnesota researchers find an ancient Chinese herb decreases a protective protein that helps cells survive allowing cell death in pancreatic cancer cells. The article is highlighted as part of the APSselect program.

Contact: Stacy Brooks
American Physiological Society

Public Release: 30-Jun-2014
Journal of Leukocyte Biology
Is the next 'new' cancer drug already in your medicine cabinet?
The same types of drugs that help reduce watery eyes and runny noses during allergy season might also help ward off tumors too. A new research report appearing in the July 2014 issue of the Journal of Leukocyte Biology suggests that antihistamines may have significant anti-cancer properties as they interfere with the function of a type of cell that is known to reduce the body's ability to fight tumors.

Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Public Release: 30-Jun-2014
FASEB Journal
Stem cells may be more widespread and with greater potential than previously believed
With the plethora of research and published studies on stem cells over the last decade, many would say that the definition of stem cells is well established and commonly agreed upon. However, a new review article appearing in the July 2014 issue of The FASEB Journal, suggests that scientists have only scratched the surface of understanding the nature, physiology and location of these cells.

Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Public Release: 30-Jun-2014
Journal of Clinical Oncology
HIV-positive people with early-stage cancer up to 4 times more likely to go untreated for cancer
HIV-infected people diagnosed with cancer are two to four times more likely to go untreated for their cancer compared to uninfected cancer patients, according to a new, large retrospective study from researchers in Penn Medicine's Abramson Cancer Center and the National Cancer Institute published online ahead of print in the Journal of Clinical Oncology.
NIH/National Cancer Institute

Contact: Steve Graff
University of Pennsylvania School of Medicine

Public Release: 30-Jun-2014
Nature Cell Biology
A key component of cell division comes to light
The in vivo visualization and monitoring of the starting points of microtubules -- filaments responsible for organising the mitotic spindle -- provides novel insight into the dynamic architecture of this structure. The findings will also contribute to understanding how the mitotic spindle is perturbed by drugs that target microtubules and that are used in chemotherapy.

Contact: Sònia Armengou
Institute for Research in Biomedicine (IRB Barcelona)

Public Release: 30-Jun-2014
Proceedings of the National Academy of Sciences
Scientists engineer nanoparticles to prevent bone cancer, strengthen bones
A research collaboration between Brigham and Women's Hospital and Dana-Farber Cancer Institute has utilized nanomedicine technologies to develop a drug-delivery system that can precisely target and attack cancer cells in the bone, as well as increase bone strength and volume to prevent bone cancer progression.
National Institutes of Health

Contact: Marjorie Montemayor-Quellenberg
Brigham and Women's Hospital

Public Release: 30-Jun-2014
Molecular & Cellular Proteomics
Moffitt researchers develop new way to combat drug resistance for melanoma patients
Moffitt Cancer Center researchers developed a new way to identify possible therapeutic targets for patients with drug resistant melanoma. It involves using liquid chromatography-multiple reaction monitoring mass spectrometry to measure biomarkers or molecules in blood and tissue that indicates cancer is present. These measurements can help researchers determine if a patient is responding to treatment.

Contact: Kim Polacek
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 30-Jun-2014
Annals of Internal Medicine
New research study shows huge savings for health care
Recently published findings in Annals of Internal Medicine by Steven Lipshultz, M.D., Wayne State University professor and chair of pediatrics and pediatrician-in-chief at the Children's Hospital of Michigan, part of the Detroit Medical Center, and colleagues could help to reduce health care charges while also protecting childhood cancer survivors from heart ailments caused by drug therapy.
Lance Armstrong Foundation, NIH/National Cancer Institute

Contact: Julie O'Connor
Wayne State University - Office of the Vice President for Research

Public Release: 30-Jun-2014
Journal of Alternative and Complementary Medicine
St. John's wort can cause dangerous interactions with many common medications
St. John's wort is the most frequently used complementary and alternative medicine treatment in the US for depression and similar psychiatric disorders. The many commonly prescribed medications that St. John's wort can interact with -- sometimes with serious consequences such as serotonin syndrome or heart disease -- are reviewed in the Journal of Alternative and Complementary Medicine.

Contact: Kathryn Ruehle
Mary Ann Liebert, Inc./Genetic Engineering News

Public Release: 30-Jun-2014
Journal of American College of Surgeons
Surgical treatment for metastatic melanoma of the liver increases overall survival
Surgical resection markedly improves survival among metastatic melanoma patients whose disease is isolated to a few areas in the liver, according to new study findings published in the July issue of the Journal of the American College of Surgeons.
National Cancer Institute, Dr Miriam & Sheldon G Adelson Medical Research Foundation

Contact: Sally Garneski
American College of Surgeons

Public Release: 30-Jun-2014
Population and Development Review
New study from population and development review finds flaws in mortality projections
A new study by Population Council demographer John Bongaarts has found that mortality projections from most low-mortality countries are more pessimistic than they should be. Existing projections fail to recognize that fewer people smoke today than used to. As a result, there will be a future decline in smoking-related mortality. This suggests that with more people living longer, pension and health care costs in coming decades will likely be higher than previously estimated.

Contact: Erin Kiernon
Population Council

Public Release: 29-Jun-2014
Nature Photonics
Single-pixel 'multiplex' captures elusive terahertz images
In an effort that advances attempts to generate images using terahertz light waves, researchers from Boston College, Duke University and the University of New Mexico report in Nature Photonics that they've developing a single-pixel 'multiplex' device that uses boutique metamaterials to capture images in the terahertz realm, which scientists say could play a crucial role in future medical and security imaging initiatives.
Office of Naval Research, National Science Foundation, DOE/Sandia National Laboratories

Contact: Ed Hayward
Boston College

Public Release: 29-Jun-2014
Nature Physics
Improved method for isotope enrichment could secure a vital global commodity
Researchers at The University of Texas at Austin have devised a new method for enriching a group of the world's most expensive chemical commodities, stable isotopes, which are vital to medical imaging and nuclear power, as reported this week in the journal Nature Physics. For many isotopes, the new method is cheaper than existing methods. For others, it is more environmentally friendly.
The University of Texas at Austin

Contact: Steve Franklin
University of Texas at Austin

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