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Showing releases 976-1000 out of 1316.

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Public Release: 15-Apr-2015
Annals of Oncology
Potential for prediction of progression for early form of breast cancer
Scientists in Manchester have identified a way to potentially predict which patients with an early form of breast cancer will experience disease progression.

Contact: Jamie Brown
jamie.brown@manchester.ac.uk
44-016-127-58383
University of Manchester

Public Release: 15-Apr-2015
Science Translational Medicine
Personal genome diagnostics study shows limitations of tumor-only sequencing for cancer
An 815-patient study from Personal Genome Diagnostics and Johns Hopkins shows that almost half of the genetic alterations identified using tumor-only sequencing are not actually associated with the patient's cancer, but instead are 'false positives' reflecting inherited mutations found in normal cells. Personalized medicine tailors treatments to the specific genetic makeup of the tumor, so this high rate of false positives has implications for the accuracy of targeted approaches if they rely on tumor-only sequencing.

Contact: Barbara Lindheim
blindheim@bllbiopartners.com
917-355-9234
BLL Partners, LLC

Public Release: 15-Apr-2015
PLOS ONE
New method increases accuracy of ovarian cancer prognosis and diagnosis
University of Utah scientists have uncovered patterns of DNA anomalies that predict a woman's outcome significantly better than tumor stage. In addition, these patterns are the first known indicator of how well a woman will respond to platinum therapy. Published in the journal PLOS ONE, the patterns were discovered by using a new mathematical technique in the analysis of DNA profiles from the Cancer Genome Atlas, a national database containing data from hundreds of ovarian cancer patients.
Utah Science, Technology, and Research Initiative, NIH/National Human Genome Research Institute, National Science Foundation

Contact: Julie Kiefer
jkiefer@neuro.utah.edu
801-597-4258
University of Utah Health Sciences

Public Release: 15-Apr-2015
Science Translational Medicine
Tumor-only genetic sequencing may misguide cancer treatment in nearly half of all patients
A study by Johns Hopkins scientists strongly suggests that sequencing tumor genomes for clues to genetic changes might misdirect treatment in nearly half of all patients unless it is compared first to a genetic readout of their noncancerous tissue.
Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, Commonwealth Foundation, American Association for Cancer Research's Stand Up To Cancer-Dream Team Translational Cancer Research Grant, John G. Ballenger Trust, and others

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine

Public Release: 15-Apr-2015
Frontiers in Public Health
Racial disparity in cancer mortality is narrowing, suggests new study
Cancer mortality remains significantly elevated among African-Americans. Between 2000 and 2010, overall mortality from cancer decreased faster among African-American women and men than among Caucasians. If current trends continue, racial disparities in cancer outcomes are expected to narrow further and might disappear over time.

Contact: Michiel Dijkstra
press@frontiersin.org
Frontiers

Public Release: 15-Apr-2015
Journal of Ovarian Research
Ovarian cancer: Genetic testing should be accessible to all women with the disease
Recent media attention has focused on American actress Angelina Jolie's decision to have her ovaries and fallopian tubes surgically removed after genetic testing for such cancers. A study led by a team from the Research Institute of the McGill University Health Center suggests that all women with ovarian cancer should be tested for these genes, regardless of their family history. The findings have clinical implications both for the treatment of this disease and for the screening of individuals at-risk.
Cancer Research Society and in part by funding from the Fonds de recherche du Québec-Santé, RI-MUHC, McGill's Faculty of Medicine, Ovarian Cancer Canada, and the Canadian Institutes of Health Research.

Contact: Julie Robert
julie.robert@muhc.mcgill.ca
514-934-1934 x71381
McGill University Health Centre

Public Release: 15-Apr-2015
Pigment Cell & Melanoma Research
Protein finding can pave the way for improved treatment of malignant melanoma
Researchers from Aarhus University have for the first time linked a new protein with malignant melanomas. The protein is detected in aggressive malignant melanoma cells and might be used to predict whether and how the cancer will spread. At the same time, the discovery also opens new doors for future improved treatment of patients with melanomas.

Contact: Mette Madsen
mette@biomed.au.dk
45-28-99-21-37
Aarhus University

Public Release: 15-Apr-2015
Metabolomics
New blood test can predict future breast cancer
By analyzing a simple blood sample, scientists from the University of Copenhagen have succeeded in predicting if a woman will get breast cancer within two to five years. The method -- a metabolic blood profile -- is still in the early stages but over time the scientists expect it could be used to predict breast cancer and more generally to predict chronic disease.
Villum Foundation

Contact: Lene Hundborg Koss
lene.h.koss@food.ku.dk
Faculty of Science - University of Copenhagen

Public Release: 14-Apr-2015
Cancer Research
Researchers discover an inactive tumor suppressor gene in lung cancer
Researchers at Genes and Cancer group at Bellvitge Biomedical Research Institute, led by Montse Sanchez-Cespedes, have identified the PARD3 gene as a tumor suppressor that is inactivated in lung cancer squamous type. The results of the study have been published in Cancer Research.

Contact: Arantxa Mena
amena@idibell.cat
34-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute

Public Release: 14-Apr-2015
American Association for Cancer Research Annual Meeting 2015
PharmaMar to present data on anticancer candidates PM1183 and plitidepsin at the AACR 2015
The new data on PharmaMar's anticancer compounds PM1183 and plitidepsin will be discussed at the AACR 2015 during poster sessions throughout the meeting. The company will present data on new molecular targets, mechanisms of actions of the compounds and combination studies in preclinical models of cancer.

Contact: Carolina Pola
cpola@pharmamar.com
34-608-933-677
Pharmamar

Public Release: 14-Apr-2015
mBio
Genetically engineered Salmonella promising as anti-cancer therapy
A new study has demonstrated that genetically modified Salmonella can be used to kill cancer cells. The study is published in this week's issue of mBio, an American Society for Microbiology online-only, open-access journal.

Contact: Aleea Khan
akhan@asmusa.org
American Society for Microbiology

Public Release: 14-Apr-2015
Gynecologic Oncology
New biomarker for uterine cancer discovered
Researchers at Uppsala University have, together with researchers from Turku and Bergen, discovered a new biomarker which makes it possible to identify women with uterine cancer who have a high risk of recurrence. The findings were recently published in the journal Gynecologic Oncology.

Contact: Per-Henrik Edqvist
per-henrik.edqvist@igp.uu.se
46-735-457-760
Uppsala University

Public Release: 14-Apr-2015
Journal of Cell Biology
High fidelity: SLU researcher finds keys to genome integrity
Lesions in DNA can occur as often as 100,000 times per cell per day. Saint Louis University researchers share a discovery that explains how cells use a process called replication fork reversal in order to deal with these roadblocks and transmit accurate genetic data.
National Institutes of Health, Saint Louis University Cancer Center

Contact: Carrie Bebermeyer
bebermcl@slu.edu
314-977-8015
Saint Louis University

Public Release: 14-Apr-2015
Cancer Cell
Recruiting the entire immune system to attack cancer
MIT studies finds that stimulating both major branches of the immune system halts tumor growth more effectively.
NIH/National Cancer Institute, NIH/National Institute for General Medical Sciences, National Science Foundation

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology

Public Release: 14-Apr-2015
Cancer Cell
Rare, deadly lymphoma demystified
This is the first-ever systematic study of the genomes of patients with ALK-negative anaplastic large cell lymphoma, a particularly aggressive form of non-Hodgkin's lymphoma.
National Institutes of Health

Contact: Lucky Tran
lt2549@columbia.edu
212-305-3689
Columbia University Medical Center

Public Release: 14-Apr-2015
Nanomedicine: Nanotechnology, Biology, and Medicine
Nanoparticles at specific temperature stimulate antitumor response
Seeking a way to stimulate antitumor responses via the immune system, Dartmouth researchers have identified the precise temperature that results in a distinct body-wide antitumor immune response that resists metastatic disease.
Dartmouth University, National Institutes of Health, Center for Molecular, Cellular, and Translational Immunological Research, Norris Cotton Cancer Center

Contact: Kirk Cassels
kirk.A.Cassels@Hitchcock.org
603-653-6177
The Geisel School of Medicine at Dartmouth

Public Release: 14-Apr-2015
American Journal of Gastroenterology
New treatment for common digestive condition Barrett's esophagus
New research from the University of Warwick and University Hospitals Coventry and Warwickshire NHS Trust could transform treatments and diagnosis for a common digestive condition which affects thousands of patients.

Contact: Kelly Parkes-Harrison
k.e.parkes@warwick.ac.uk
0247-615-0868
University of Warwick

Public Release: 13-Apr-2015
Digestive and Liver Diseases
Mayo profile identifies patients most at risk of developing pancreatic cancer
When people learn they have a lesion in their pancreas that could become pancreatic cancer, they often request frequent CT scans and biopsies, or surgery. Often the lesion is nothing to worry about. A team of international physicians, led by researchers at Mayo Clinic's campus in Jacksonville, Florida, has developed a profile of the patient most at risk of developing lesions that are most likely to develop into cancer.
Mayo Clinic/Joyce E. Baker Foundation

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-0746
Mayo Clinic

Public Release: 13-Apr-2015
British Journal of Cancer
Study finds testicular cancer link for muscle-building supplements
A new study associates taking muscle-building supplements with an increased risk of testicular cancer. Men who used such pills and powders were more likely to have developed testicular cancer than those who did not, especially if they started before age 25, took more than one supplement, or used the supplements for three or more years.
National Institutes of Health, National Natural Science Foundation of China, Beijing Natural Science Foundation, Beijing Nova Program

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University

Public Release: 13-Apr-2015
Developmental Cell
CNIO experts identify an oncogene regulated by nutrients
In response to nutrient excess, the MCRS1 protein acts as a 'switch' for mTOR, a protein that is altered in cancer, diabetes and disorders associated with aging. The results correlate with increased MCRS1 protein levels in samples taken from patients with colorectal cancer. Blocking this protein may prove to be an effective treatment for cancer or other diseases associated with mTOR alterations.

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)

Public Release: 13-Apr-2015
Cancer Cell
Melanoma's 'safe haven' targeted for shut-down
Melanoma cells become drug resistant by using surrounding healthy cells to provide a 'safe haven' from treatment, according to new research published in Cancer Cell on April 13, 2015.
Cancer Research UK

Contact: Paul Thorne
paul.thorne@cancer.org.uk
44-203-469-8352
Cancer Research UK

Public Release: 13-Apr-2015
Proceedings of the National Academy of Sciences
Gold by special delivery intensifies cancer-killing radiation
Researchers at Brown and the University of Rhode Island have demonstrated what could become a more precise method for targeting cancer cells for radiation. The method would use cancer-seeking peptides to ferry nanoparticles of gold to the site. The gold then helps focus radiation on the cancer cells.
National Institutes of Health

Contact: Kevin Stacey
kevin_stacey@brown.edu
401-863-3766
Brown University

Public Release: 13-Apr-2015
Health Affairs
The cost and quality of cancer care in Health Affairs' April issue
The April issue of Health Affairs contains a cluster of papers focusing on the cost and quality of cancer care. Other subjects covered in the issue: health care payment reform and the diminished number of uninsured young adults. Publication of the cancer studies in the April issue was supported by Precision Health Economics and the Celgene Corporation.

Contact: Sue Ducat
sducat@projecthope.org
301-841-9962
Health Affairs

Public Release: 13-Apr-2015
Proceedings of the National Academy of Sciences
Moffitt develops new method to characterize the structure of a protein that promotes tumor growth
offitt Cancer Center researchers have developed a new method to identify a previously unknown structure in a protein called MDMX. MDMX is a crucial regulatory protein that controls p53 -- one of the most commonly mutated genes in cancer.
National Institutes of Health, Florida Department of Health

Contact: Kim Polacek
Kim.Polacek@Moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute

Public Release: 13-Apr-2015
Cancer Cell
Two Cell Press journals review relationship between immune system and cancer
In a joint special issue on cancer, immunity, and immunotherapy, Cancer Cell and Trends in Immunology explore the history of this work and review how immunology and cancer research currently intersect. Articles explore drugs that eliminate cancer's hold on the immune system, as well as the ways the immune response is affected by anti-cancer therapies and vice versa.

Contact: Joseph Caputo
jcaputo@cell.com
617-335-6270
Cell Press

Showing releases 976-1000 out of 1316.

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