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Showing releases 976-1000 out of 1247.

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Public Release: 28-Nov-2013
High cholesterol fuels the growth and spread of breast cancer
A byproduct of cholesterol functions like the hormone estrogen to fuel the growth and spread of the most common types of breast cancers, researchers at the Duke Cancer Institute report.
National Institutes of Health

Contact: Sarah Avery
Duke University Medical Center

Public Release: 27-Nov-2013
Science Translational Medicine
Scientists develop way to successfully give nanoparticle therapeutics orally
Researchers at Brigham and Women's Hospital and Massachusetts Institute of Technology are the first to report in the field of nanomedicine a new type of nanoparticle that can be successfully absorbed through the digestive tract.
National Institutes of Health

Contact: Marjorie Montemayor-Quellenberg
Brigham and Women's Hospital

Public Release: 27-Nov-2013
Cancer Epidemiology, Biomarkers & Prevention
Negative BRCA testing may not always imply lowered breast cancer risk
Women who are members of families with BRCA2 mutations but who test negative for the family-specific BRCA2 mutations are still at greater risk for developing breast cancer compared with women in the general population, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
NIH/National Institute for Health Research

Contact: Jeremy Moore
American Association for Cancer Research

Public Release: 27-Nov-2013
Annals of Oncology
Global study reveals pandemic of untreated cancer pain due to over-regulation of pain medicines
A ground-breaking international collaborative survey, published in Annals of Oncology, shows that more than half of the world's population live in countries where regulations that aim to stem drug misuse leave cancer patients without access to opioid medicines for managing cancer pain.

Contact: Vanessa Pavinato
European Society for Medical Oncology

Public Release: 27-Nov-2013
Nature Cell Biology
MD Anderson researchers identify a rescuer for vital tumor-suppressor
The tumor-suppessing protein PTEN is absent in many cancers, yet defects in the PTEN gene do not account for this disappearance. MD Anderson researchers identified an enzyme that keep PTEN from being fed to the cell's protein-recycling mechanism.
NIH/National Cancer Institute, Cancer Prevention and Research Institute of Texas

Contact: Scott Merville
University of Texas M. D. Anderson Cancer Center

Public Release: 26-Nov-2013
Cell Stem Cell
Researchers at Penn uncover mechanism behind blood stem cells' longevity
Researchers have long wondered what allows blood stem cells to persist for decades, when their progeny last for days, weeks or months before they need to be replaced. Now, a study from the University of Pennsylvania has uncovered one of the mechanisms that allow these stem cells to keep dividing in perpetuity.
National Institutes of Health, Human Frontier Science Program, American Heart Association

Contact: Evan Lerner
University of Pennsylvania

Public Release: 26-Nov-2013
Breast Cancer Research
High-fat diet during puberty speeds up breast cancer development
New findings show that eating a high-fat diet beginning at puberty speeds up the development of breast cancer and may actually increase the risk of cancer similar to a type often found in younger adult women.
NIH/National Institute of Environmental Health, NIH/National Cancer Institute

Contact: Sarina Gleason
Michigan State University

Public Release: 26-Nov-2013
Genes & Development
Scientists discover how leukemia cells exploit 'enhancer' DNA elements to cause lethal disease
A team of researchers at Cold Spring Harbor Laboratory has identified a leukemia-specific stretch of DNA called an enhancer element that enables cancerous blood cells to proliferate in acute myeloid leukemia, a devastating cancer that is incurable in 70 percent of patients. Just as important, the findings offer a mechanistic insight into how a new class of promising drugs -- one version of which is already in human clinical trials -- appears to halt the growth of cancer cells so effectively.
National Institutes of Health

Contact: Jaclyn Jansen
Cold Spring Harbor Laboratory

Public Release: 25-Nov-2013
Certain symptom clusters experienced after surgery for esophageal cancer predict poor prognosis
A new study has found that several months after surgery for esophageal cancer, different symptoms cluster together in different types of patients. In addition, patients with certain symptom clusters have an increased risk of dying from their disease. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society.

Contact: Amy Molnar

Public Release: 25-Nov-2013
Proceedings of the National Academy of Sciences
Using microRNA fit to a T (cell)
Researchers at the University of California, San Diego School of Medicine have successfully targeted T lymphocytes -- which play a central role in the body's immune response -- with another type of white blood cell engineered to synthesize and deliver bits of non-coding RNA or microRNA.
National Institutes of Health

Contact: Scott LaFee
University of California - San Diego

Public Release: 25-Nov-2013
Journal of Clinical Oncology
Nurse navigators help cancer patients cope early in care
When Group Health patients received support from a nurse navigator, or advocate, soon after a cancer diagnosis, they had better experiences and fewer problems with their care -- particularly in health information, care coordination, and psychological and social care -- according to a randomized controlled trial in the Journal of Clinical Oncology.
NIH/National Cancer Institute

Contact: Rebecca Hughes
Group Health Research Institute

Public Release: 25-Nov-2013
Journal of Experimental Medicine
Killer cocktail fights brain cancer
A novel immune-boosting drug combination eradicates an aggressive form of brain cancer in mice, according to a study in the Journal of Experimental Medicine.
Swiss National Science Foundation, European Union

Contact: Rita Sullivan King
Rockefeller University Press

Public Release: 25-Nov-2013
Journal of Clinical Investigation
JCI early table of contents for Nov. 25, 2013
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Nov. 25, 2013, in the JCI: Predicting nasopharyngeal carcinoma patient response to radiation therapy; Circadian clock proteins maintain neuronal cell function; Identifying targets of autoantibodies; Balancing T cell populations; Identification of a genetic mutation associated with steroid-resistant nephritic syndrome; Insights into type 2B von Willebrand disease, and more.

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 25-Nov-2013
Journal of Clinical Investigation
Predicting nasopharyngeal carcinoma patient response to radiation therapy
In this issue of the Journal of Clinical Investigation, Yu-Sun Chang and colleagues at Chang Gung University sought to find a way to predict which individual cases of NPC would be sensitive to radiation therapy.
Ministry of Education -- Taiwan, Chang Gung Memorial Hospital

Contact: Corinne Williams
Journal of Clinical Investigation

Public Release: 25-Nov-2013
Annals of Internal Medicine
Nov. 26, 2013, Annals of Internal Medicine tip sheet
The United States Preventive Services Task Force found insufficient evidence to recommend for or against screening for oral cancer by primary care physicians in asymptomatic adults, according to an article published in Annals of Internal Medicine.

Contact: Megan Hanks
American College of Physicians

Public Release: 25-Nov-2013
JAMA Internal Medicine
Cervical cancer screening overused in some groups of women
For the past 10 years, clinicians throughout the United States have been performing unnecessary Pap tests for cervical cancer screening in certain groups of women, according to a researcher from Huntsman Cancer Institute at the University of Utah.

Contact: Jill Woods
University of Utah Health Sciences

Public Release: 25-Nov-2013
Journal of Geriatric Oncology
EORTC Cancer in the Elderly Task Force investigates appropriate treatment for elderly patients
Many things, not simply chronological age, contribute to treatment tolerance and outcome in older patients with cancer, and these present challenges when determining appropriate treatment. Recently, though, members of the EORTC Cancer in the Elderly Task Force, in a paper published in the Journal of Geriatric Oncology, evaluated the physiological reserves of elderly patients with cancer and described the most relevant biomarkers that might potentially serve to indicate their functional biological age.
Fonds Cancer of Belgium, Fonds voor Wetenschappelijk Onderzoek Vlaanderen, Vlaamse Liga tegen Kanker

Contact: John Bean
European Organisation for Research and Treatment of Cancer

Public Release: 25-Nov-2013
2-way traffic enables proteins to get where needed, avoid disease
It turns out that your messenger RNA may catch more than one ride to get where it's going.
National Institutes of Health

Contact: Toni Baker
Medical College of Georgia at Georgia Regents University

Public Release: 25-Nov-2013
Tobacco Control
Graphic warning labels on cigarette packages reduce smoking rates
Graphic cigarette warning labels in the US could decrease smokers to 5.3-8.6 million.

Contact: Sherri McGinnis Gonzalez
University of Illinois at Chicago

Public Release: 25-Nov-2013
UNC scientists find potential cause for deadly breast cancer relapse
Adriana S. Beltran, Ph.D., a research assistant professor in the UNC School of Medicine, found that the protein Engrailed 1 is overexpressed in basal-like carcinomas, and she designed a chain of amino acids to shut down the protein and kill basal-like tumors in the lab.
National Institutes of Health, US Department of Defense

Contact: Mark Derewicz
University of North Carolina Health Care

Public Release: 25-Nov-2013
Clevelanders: Lighting up in a new way
A new data brief released by the Prevention Research Center for Healthy Neighborhoods at Case Western Reserve University shows that more than one-in-five African-American young adults in Cleveland, ages 18 to 29, routinely uses little cigars.

Contact: Jessica Studeny
Case Western Reserve University

Public Release: 25-Nov-2013
Cancer Cell
Latest research findings offer potential new treatments for acute myeloid leukemia
In two separate studies on CEBPA mutations in acute myeloid leukemia (AML) subtypes, researchers led by Professor Daniel Tenen, Director, Cancer Science Institute of Singapore at the National University of Singapore, successfully identified and validated a gene known as Sox4 as a potential therapeutic target and a class of anti-cancer drugs, histone deacetylase inhibitors, as potential candidates in the treatment of certain AML.

Contact: Kimberley Wang
National University of Singapore

Public Release: 25-Nov-2013
Journal of Experimental Medicine
New immunotherapy for malignant brain tumors
Glioblastoma is one of the most ominous brain tumors. Despite aggressive surgery, radiation and chemotherapy the outcome of this disease is almost always fatal. A UZH research team has now achieved success with a novel form of treatment that involves encouraging the body's own immune system to recognise and eliminate cancer cells in the brain.

Contact: Burkhard Becher, Ph.D.
University of Zurich

Public Release: 25-Nov-2013
Developmental Cell
Dysfunctional mitochondria may underlie resistance to radiation therapy
The resistance of some cancers to the cell-killing effects of radiation therapy may be due to abnormalities in the mitochondria -- the cellular structures responsible for generating energy, according to an international team of researchers. Their findings are published in the Nov. 25 issue of Developmental Cell.
National Institutes of Health, Leukemia & Lymphoma Society, Natural Sciences and Engineering Research Council of Canada, Spanish Ministry

Contact: Sharon Parmet
University of Illinois at Chicago

Public Release: 23-Nov-2013
4th Quadrennial World Federation of Neuro-Oncology
Update: 50 percent of patients in Cedars-Sinai brain cancer study alive after 5 years
Eight of 16 patients participating in a study of an experimental immune system therapy directed against the most aggressive malignant brain tumors -- glioblastoma multiforme -- survived longer than five years after diagnosis, according to Cedars-Sinai researchers, who presented findings Nov. 23 at the Fourth Quadrennial Meeting of the World Federation of Neuro-Oncology.
IMUC, Ltd.

Contact: Sandy Van
Cedars-Sinai Medical Center

Showing releases 976-1000 out of 1247.

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