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Bioinformatics

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Key: Meeting M      Journal J      Funder F

Showing releases 1-25 out of 761.

1 | 2 | 3 | 4 | 5 > >>

Public Release: 1-Apr-2015
Genome Research
Longer DNA fragments reveal rare species diversity
A challenge in metagenomics is that the more commonly used sequencing machines generate data in short lengths, while short-read assemblers may not be able to distinguish among multiple occurrences of the same or similar sequences, making it difficult to identify all the members in a microbial community. In the April 2015 issue of Genome Research, a team including DOE JGI researchers compared two ways of using next generation Illumina sequencing machines to help with this.
DOE/Office of Science

Contact: David Gilbert
degilbert@lbl.gov
DOE/Joint Genome Institute

Public Release: 1-Apr-2015
Nature
Scientists drill down to genetic root of prostate tumor development
Scientists have revealed the root of prostate cancers in individual men, discovering that despite huge genetic variety between tumors they also share common gene faults -- insight that could offer new treatment hopes.

Contact: Emily Head
emily.head@cancer.org.uk
020-346-96189
Cancer Research UK

Public Release: 31-Mar-2015
Applications in Plant Sciences
Simplifying SNP discovery in the cotton genome
Researchers have developed a strategy that simplifies the discovery of useful single-nucleotide polymorphisms within the complex cotton genome. This method, recently published in Applications in Plant Sciences, will be useful for marker-assisted selection, linkage and QTL mapping, and genetic diversity studies. It has the added benefit of being applicable to other economically important allotetraploid species, including the brassicas, and can be extended to species that do not currently have a reference genome.
Cotton Incorporated Fellowship

Contact: Beth Parada
apps@botany.org
Botanical Society of America

Public Release: 31-Mar-2015
Four centers in Spain join forces to bridge the gap between research and clinical practice
Today, four centers in Barcelona jointly launch a program that seeks to offer advanced research training for physicians and to strengthen the collaboration between basic research centers and hospitals.

Contact: Laia Cendrós
laia.cendros@crg.eu
34-607-611-798
Center for Genomic Regulation

Public Release: 30-Mar-2015
Scientists honored in Biochemical Society Awards
Eleven distinguished scientists and exceptional early career researchers have been honored in the Biochemical Society's annual Awards.

Contact: Alastair Stewart
alastair.stewart@biochemistry.org
44-207-685-2401
Biochemical Society

Public Release: 30-Mar-2015
Journal of Clinical Investigation
DNA alterations may predict treatment response in chronic myelomonocytic leukemia patients
A new study in the Journal of Clinical Investigation identifies a molecular signature that is predictive of chronic myelomonocytic leukemia patient response to the DNA methyltransferase inhibitor decitabine.
Leukemia and Lymphoma Society, Sass Foundation, National Institutes of Health, US Department of Defense, Josie Robertson Investigator Program, Damon Runyon Clinical Investigator Award, Evans Foundation, French National Cancer Institute

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation

Public Release: 26-Mar-2015
Neuron
Sea slug provides new way of analyzing brain data
Scientists say our brains may not be as complicated as we once thought -- and they're using sea slugs to prove it.
Medical Research Council, Agence Nationale de la Recherche

Contact: Morwenna Grills
Morwenna.Grills@manchester.ac.uk
44-016-127-52111
University of Manchester

Public Release: 25-Mar-2015
GigaScience
Mobile DNA sequencer shows potential for disease surveillance
A pocket-sized device that can rapidly determine the sequence of an organism's DNA has shown its potential in disease detection, according to a study published in the open access, open data journal GigaScience.

Contact: Joel Winston
Joel.Winston@biomedcentral.com
44-020-319-22081
BioMed Central

Public Release: 23-Mar-2015
Journal of Clinical Microbiology
Unraveling cystic fibrosis puzzle, taking it personally matters
A comprehensive bioinformatics analysis of human lung bacteria from a uniquely detailed, long-term data set has discovered a previously unknown relationship between population changes in a single bacterial species and subsequent flare-ups of disease in cystic fibrosis. The study was made possible by the unusual cooperation of a single cystic fibrosis patient -- the lead author in the study.
National Institutes of Health, Cystic Fibrosis Foundation

Contact: James Hathaway
jbhathaw@uncc.edu
704-687-5743
University of North Carolina at Charlotte

Public Release: 23-Mar-2015
Cell Reports
Cytomegalovirus hijacks human enzyme for replication
Researchers at Princeton have discovered that cytomegalovirus manipulates a process called fatty acid elongation, which makes the very-long-chain fatty acids necessary for virus replication. Published in the journal Cell Reports on March 3, the research team identified a specific human enzyme -- elongase enzyme 7 -- that the virus induces to turn on fatty acid elongation.
National Institutes of Health, American Heart Association

Contact: Tien Nguyen
tienn@princeton.edu
919-961-4753
Princeton University

Public Release: 20-Mar-2015
Journal of Antimicrobial Chemotherapy
Scientists must reduce antibiotic use in experiments
Scientists should reduce antibiotic use in lab experiments -- according to a researcher at the University of East Anglia. Microbiology, molecular biology and genetic research such as the Human Genome Project use antibiotics in experiments. But it all adds to the global problem of antibiotic resistance according to Dr. Laura Bowater, from UEA's Norwich Medical School.

Contact: Lisa Horton
l.horton@uea.ac.uk
44-016-035-92764
University of East Anglia

Public Release: 19-Mar-2015
Advances in Genome Biology & Technology (AGBT) 2015
TGAC's take on the first portable DNA sequencing 'laboratory'
The Genome Analysis Centre (TGAC) take part in ground breaking portable DNA sequencing trial, the MinION Access Programme. The first remote laboratory will allow TGAC's researchers to carry out live experiments for immediate analysis out in the field.
Oxford Nanopore Technologies

Contact: Hayley London
hayley.london@tgac.ac.uk
44-016-034-50107
The Genome Analysis Centre

Public Release: 18-Mar-2015
Nucleic Acids Research
Los Alamos creates bioinformatics tool for metagenome analysis
Scientists at Los Alamos National Laboratory have developed a new method for DNA analysis of microbial communities such as those found in the ocean, the soil, and our own guts.
Defense Threat Reduction Agency/Chemical and Biological Technologies-Joint Science and Technology Office

Contact: Nancy Ambrosiano
nwa@lanl.gov
505-667-0471
DOE/Los Alamos National Laboratory

Public Release: 17-Mar-2015
Immunity
New metabolic mechanisms discovered that regulate the macrophage's role in immune response
A group of researchers from Washington University in St. Louis, Agios Pharmaceuticals and ITMO University has discovered new metabolic mechanisms that regulate macrophage polarization - the unique ability of these immune cells to change their specialization depending on the required task. The research opens new possibilities for the development of a new class of drugs based on controlling the metabolism of immune cells. The results were published today in the Immunity journal.

Contact: Dmitry Malkov
d.malkoves@gmail.com
7-953-377-5508
ITMO University

Public Release: 17-Mar-2015
Management of Biological Invasions
The need for a more open attitude towards invasive alien species data
New research published with the support of the FP7 large-scale bioinformatics project Building the European Biodiversity Observation Network and the Alien Challenge COST action reveals the importance of open data in the study and control of invasive alien species. The study was published open access in the journal Management of Biological Invasions.

Contact: Quentin Groom
quentin.groom@br.fgov.be
Pensoft Publishers

Public Release: 16-Mar-2015
Journal of Proteome Research
Milk protein comparison unveils nutritional gems for developing babies
Human babies appear to need more of a nutritional boost from breast-milk proteins than do infants of one of their closest primate relatives, suggests a study comparing human milk with the milk of rhesus macaque monkeys.
University of California -- Davis, National Institutes of Health

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis

Public Release: 16-Mar-2015
American Journal of Epidemiology
Genetics: No evidence of role in racial mortality gap
There is still no evidence of genetic difference between blacks and whites to account for the health disparities in cardiovascular disease, according to a new study by McGill University researchers. Published in the American Journal of Epidemiology, the researchers suggest that after a decade of genetic studies, factors such as lifestyle, education and socio-economics -- not genetics -- are more promising avenues to understanding racial health disparities.

Contact: Cynthia Lee
cynthia.lee@mcgill.ca
514-398-6754
McGill University

Public Release: 16-Mar-2015
Nature Communications
Penn vet team points to new colon cancer culprit
Colon cancer is a heavily studied disease -- and for good reason. It is one of the leading causes of cancer-related deaths worldwide, and its numbers are on the rise, from 500,000 deaths in 1990 to 700,000 in 2010. This growth comes despite scientists' ever-increasing knowledge of the genetic mutations that initiate and drive this disease. Now, a team of researchers from the University of Pennsylvania has found evidence of a new culprit in the disease, a protein called MSI2.
NIH/National Institute of Diabetes and Digestive and Kidney Diseases, NIH/National Cancer Institute

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania

Public Release: 16-Mar-2015
PLOS Computational Biology
New possibilities for the treatment of breast cancer arise, with the help of mathematics
Researchers of three of Switzerland's leading scientific institutions have brought to light a means of reprogramming a flawed immune response into an efficient anti-tumoral one by the results of a translational trial relating to breast cancer. Thanks to the innovative combination of mathematical modelization and experimentation, only 20 tests were necessary, whereas traditional experimentation would have required 596 tests to obtain the same results.

Contact: Ioannis Xenarios
Ioannis.Xenarios@isb-sib.ch
41-216-924-031
Swiss Institute of Bioinformatics

Public Release: 16-Mar-2015
BMC Psychiatry
Risk patterns identified that make people more vulnerable to PTSD
Researchers from NYU Langone Medical Center have built a new computational tool that identifies 800 different ways people are at increased risk for post-traumatic stress disorder, permitting for the first time a personalized prediction guide.
NIH/National Institute of Mental Health

Contact: Jim Mandler
jim.mandler@nyumc.org
212-404-3525
NYU Langone Medical Center / New York University School of Medicine

Public Release: 16-Mar-2015
Oncogene
When cancer cells stop acting like cancer
Cancer cells crowded tightly together suddenly surrender their desire to spread, and this change of heart is related to a cellular pathway that controls organ size.
National Institutes of Health

Contact: Karen Teber
km463@georgetown.edu
Georgetown University Medical Center

Public Release: 13-Mar-2015
Stem Cell Reports
OSKM stoichiometry determines iPS cell reprogramming
Researchers at Kyoto University's Center for iPS Cell Research and Application discover a simple way to increase the production of induced pluripotent stem cells. A major hurdle in reprogramming science is generating a sufficient number of iPS cells to conduct basic research experiments. Yet, a report published in Stem Cell Reports shows that simply adding 9 amino acids to the induction transgene Klf4 dramatically elevates the production of fully reprogrammed mouse iPS cells.

Contact: Akemi Nakamura
media@cira.kyoto-u.ac.jp
81-753-667-005
Center for iPS Cell Research and Application - Kyoto University

Public Release: 11-Mar-2015
Molecular Systems Biology
Researchers develop tool to understand how the gut microbiome works
Researchers at Harvard Medical School and Columbia University in the United States have developed a way to study the functions of hard-to-grow bacteria that contribute to the composition of the gut microbiome.

Contact: Barry Whyte
barry.whyte@embo.org
EMBO

Public Release: 11-Mar-2015
Nature
Length matters
Mutations in the MECP2 gene are the cause of the devastating childhood neurological disorder Rett Syndrome. Despite intense efforts spanning several decades the precise function of MECP2 has been difficult to pin down. Research primarily funded by the Rett Syndrome Research Trust and NINDS, and published today in Nature reveals important information that could lead to new treatment approaches. The study, led by Michael Greenberg, Ph.D., Chairman of the Department of Neurobiology at Harvard University, shows that MECP2 dampens the expression of long genes.
Rett Syndrome Research Trust, NIH/National Institute of Neurological Disorders and Stroke, Damon Runyon Cancer Research Foundation, William Randolph Hearst, Howard Hughes Medical Institute, and others

Contact: Monica Coenraads
monica@rsrt.org
203-445-0041
Rett Syndrome Research Trust

Public Release: 9-Mar-2015
DNA and Cell Biology
Viagra in combination with new drugs can have anti-cancer, antibacterial, and therapeutic effects
Chaperone proteins play an important role in protein folding in human cells and in bacteria and are promising new targets for drugs to treat cancer and Alzheimer's disease and for novel antiviral drugs and antibiotics. How existing drugs such as Viagra or Cialis and a derivative of the drug Celebrex, for example, can reduce the activity of a specific chaperone protein, with the potential for anti-tumor and anti-Alzheimer's disease effects, is described in a Review article in DNA and Cell Biology.

Contact: Kathryn Ryan
kryan@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News

Showing releases 1-25 out of 761.

1 | 2 | 3 | 4 | 5 > >>