EurekAlert! InContext Modules

Public Release: 6-May-2013

ACS Nano
A KAIST research team developed in vivo flexible large scale integrated circuits
A team led by Professor Keon Jae Lee from the Department of Materials Science and Engineering at KAIST has developed in vivo silicon-based flexible large scale integrated circuits for bio-medical wireless communication.

Public Release: 5-May-2013

Nature Methods
A new cost-effective genome assembly process
Genome assembly, the molecular equivalent of trying to put together a multi-million piece jigsaw puzzle without knowing what the picture on the cover of the box is, remains challenging due to the very large number of very small pieces, which must be assembled using current approaches. As reported May 5 online in the journal Nature Methods, a collaboration involving DOE JGI researchers has resulted in an improved and fully automated workflow for genome assembly.

US Department of Energy

Public Release: 2-May-2013
Plant geneticist elected member of country's first learned society
Renowned geneticist Susan Wessler at the University of California, Riverside has been elected a member of the American Philosophical Society, founded in 1743 by Benjamin Franklin for the purpose of "promoting useful knowledge." Wessler holds a University of California President's Chair and is a distinguished professor of genetics in the Department of Botany and Plant Sciences. Wessler's research focuses on plant transposable elements and their role in the evolution of plant genomes.

American Philosophical Society

Public Release: 2-May-2013

Proceedings of the National Academy of Sciences
Researchers find active transporters are universally leaky
Illinois professor of biochemistry Emad Tajkhorshid and his team found that as active transporters in cell membranes undergo conformational changes to allow their main substrates to pass through through, small molecules like water slip through as well.

Public Release: 2-May-2013

Nature
3D simulation shows how form of complex organs evolves by natural selection
Researchers at the Institute of Biotechnology at the Helsinki University and the Universitat Autònoma de Barcelona have developed the first three-dimensional simulation of the evolution of morphology by integrating the mechanisms of genetic regulation that take place during embryo development.

Public Release: 1-May-2013

Nature Genetics
New genetic clues to breast and ovarian cancer
A major international study involving a Simon Fraser University scientist has found that sequence differences in a gene crucial to the maintenance of our chromosomes' integrity predispose us to certain cancers. Nature Genetics published the study on March 27, 2013.

Public Release: 30-Apr-2013
UC Riverside plant cell biologist elected to the National Academy of Sciences
Xuemei Chen, a professor of plant cell and molecular biology at UC Riverside has been elected a member of the National Academy of Sciences for her excellence in original scientific research. Membership in the NAS is one of the highest honors given to a scientist or engineer in the United States. Xuemei has made pioneering contributions to our understanding of how cells in an undifferentiated meristem of a plant shoot ultimately form a flower.

National Academy of Sciences

Public Release: 30-Apr-2013

Interface
Behavior of seabirds during migration revealed
The behavior of seabirds during migration -- including patterns of foraging, rest and flight -- has been revealed in new detail using novel computational analyses and tracking technologies.

Public Release: 29-Apr-2013
OGI's investment in cytognomix contributes to the Shannon Human Splicing Pipeline's success
Ontario Genomics Institute congratulates Cytognomix on the success of the Shannon Human Splicing Pipeline, which was recently purchased by the National Cancer Institute in the US. In 2009, OGI invested in Cytognomix through its Pre-commercialization Business Development Fund.

Public Release: 26-Apr-2013
Researchers receive high honor from American Society of Plant Biologists
Two UC Riverside scientists have received high recognition from the American Society of Plant Biologists (ASPB) for their contributions to the field of plant biology. Natasha Raikhel has been named the recipient of the Adolph E. Gude, Jr. Award, granted every three years in recognition of outstanding service to plant biology. Susan Wessler has been named an ASPB Fellow, granted in recognition of distinguished and long-term contributions to plant biology and service to the society.

American Society of Plant Biologists

Public Release: 25-Apr-2013

Cell
Researchers identify key cellular organelle involved in gene silencing
How exactly microRNAs repress target gene expression is not well understood. A team of scientists led by UC Riverside geneticists has conducted a study on plants that shows that the site of action of the repression of target gene expression occurs on the endoplasmic reticulum, a cellular organelle that is an interconnected network of membranes -- essentially, flattened sacs and branching tubules -- that extends like a flat balloon throughout the cytoplasm in plant and animal cells.

National Institutes of Health, National Science Foundation, Howard Hughes Medical Institute

Public Release: 25-Apr-2013
New research projects to enhance bioinformatics and computational biology tools and methodologies
New research projects to enhance bioinformatics and computational biology tools and methodologies $11 million investment will help researchers maximize the utilization of data collected through genomics research for the benefit of Canadians.

Genome Canada, Canadian Institutes of Health Research

Public Release: 25-Apr-2013

Cell
Periodic bursts of genetic mutations drive prostate cancer
Cancer is typically thought to develop after genes gradually mutate over time, finally overwhelming the ability of a cell to control growth. But a new closer look at genomes in prostate cancer by an international team of researchers reveals that, in fact, genetic mutations occur in abrupt, periodic bursts, causing complex, large scale reshuffling of DNA driving the development of prostate cancer.

Public Release: 23-Apr-2013
Seena Magowitz Foundation donates $500,000 for TGen pancreatic cancer research
The Seena Magowitz Foundation has donated $500,000 from two charity golf tournaments dedicated to supporting pancreatic cancer research at the Translational Genomics Research Institute. Past donations from the Seena Magowitz Foundation have helped fund significant scientific research that is making a difference in the lives of pancreatic cancer patients and their families.

Seena Magowitz Foundation

Public Release: 23-Apr-2013
Wayne State University startup, Advaita, to participate in new Michigan I-Corps program
Advaita, a Plymouth, MI biotechnology startup company spun out from Wayne State University, is one of 25 companies selected to participate in the new Michigan I-Corps program starting May 2013.

State of Michigan

Public Release: 23-Apr-2013

Applied and Environmental Microbiology
Contact killing of Salmonella by human fecal bacteria
Researchers at the Institute of Food Research have recently found a novel mode of interaction between Salmonella, a food-borne pathogen, and the bacteria that live in our guts. Fecal bacteria collected from healthy donors effectively inactivated Salmonella, when they were allowed close contact. Mathematical modeling of this interaction is now being used to find new ways of controlling Salmonella.

Biotechnology and Biological Sciences Research Council

Public Release: 22-Apr-2013
OHSU teams with Intel to decode the root causes of cancer and other complex diseases
Oregon Health and Science University and Intel Corp. are teaming up to develop next-generation computing technologies that advance the field of personalized medicine by dramatically increasing the speed, precision and cost-effectiveness of analyzing a patient's individual genetic profile.

Public Release: 22-Apr-2013

ZooKeys
Online biodiversity databases audited: 'Improvement needed'
An audit of more than 9,000 species occurrence records in two online databases has uncovered a large number of errors. The study also highlighted the fact that online database publishers currently take no responsibility for the content of their databases, and do not collaborate with their data providers in checking and correcting the online data. The audit results and the associated data files have been published in the open access journal ZooKeys.

Public Release: 21-Apr-2013

Nature Genetics
Genetics defines a distinct liver disease
For the first time, scientists show that a leading cause of liver transplant, primary sclerosing cholangitis (PSC), is a distinct disease from inflammatory bowel disease, opening up new avenues for specific PSC treatments.

Public Release: 21-Apr-2013

Nature Biotechnology
Hundreds of alterations and potential drug targets to starve tumors identified
A massive study analyzing gene expression data from 22 tumor types has identified multiple metabolic expression changes associated with cancer. The analysis, conducted by researchers at Columbia University Medical Center, also identified hundreds of potential drug targets that could cut off a tumor's fuel supply or interfere with its ability to synthesize essential building blocks. The study was published today in the online edition of Nature Biotechnology.

National Institutes of Health, National Centers for Biomedical Computing, Ellison Medical Foundation, NIH/National Institute of Environmental Health Sciences

Public Release: 19-Apr-2013

Chemistry & Biology
An IRB study contributes to the understanding and prevention of the side effects caused by drugs
The scientists Miquel Duran and Patrick Aloy provide a description of the molecular processes responsible for more than 1,000 secondary effects. This knowledge, which is available to the scientific community, may be of great use to minimize and predict adverse effects during drug design.

Public Release: 18-Apr-2013
100+ million mapped (and growing) records of nearly every living US species
Biodiversity Information Serving Our Nation or BISON is the only system of its kind; a unique, web-based Federal resource for finding species in the U. S. and territories. Its size is unprecedented, offering more than 100 million mapped records of nearly every living species nationwide and growing. And the vast majority of the records are specific locations, not just county or state records.

US Geological Survey

Public Release: 18-Apr-2013

American Journal of Human Genetics
Evolving genes lead to evolving genes
Researchers have designed a new method that is opening doors to understanding how we humans have genetically adapted to our local environments and identifying genes that are involved in human evolution.

Wellcome Trust, Max Planck Society

Public Release: 17-Apr-2013

eLife
CU-Boulder study looks at microbial differences between parents, kids and dogs
As much as dog owners love their children, they tend to share more of themselves, at least in terms of bacteria, with their dogs.

Howard Hughes Medical Institute, Crohn's and Colitis Foundation of America, National Institutes of Health

Public Release: 17-Apr-2013

Science Translational Medicine
New computational model can predict breast cancer survival
Columbia Engineering researchers, led by Dimitris Anastassiou, professor of electrical engineering and member of the Columbia Initiative in Systems Biology, have developed a new computational model that is highly predictive of breast cancer survival and, they hope, perhaps all cancers.


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