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Showing stories 101-125 out of 126 stories.
19-Jun-2001
SNS and biological research Three world-class biological instruments are being designed for the Spallation Neutron Source. They will help biologists determine the atomic-level structure of proteins and other signaling compounds that allow cells to communicate and coordinate activities across an organism. The research could lead to safer, more effective drugs. Contact: Billy Stair
19-Jun-2001
Microbe probe ORNL researchers are using gene chips, mass spectrometry, and computational analysis to understand what microbe genes do. Contact: Billy Stair
19-Jun-2001
Protein prediction tool has good prospects ORNL ranks high in its ability to computationally predict protein structures. The next step is to speed up predictions to facilitate the search for effective drugs. Contact: Billy Stair
19-Jun-2001
Human genome analyzed using supercomputer A computational analysis of the human genome by ORNL and UT researchers provides insights into what our genes do. Contact: Billy Stair
19-Jun-2001
The mouse house: From old to new While some ORNL mice are allowed to grow old for studies of aging, mutant mouse embryos are being frozen, awaiting birth after the new Mouse House is built. Contact: Billy Stair
19-Jun-2001
Lab on a chip used for protein studies ORNL's lab on a chip is being used commercially to identify proteins and shows promise for drug discovery and disease screening. Contact: Billy Stair
19-Jun-2001
Rapid genetic disease screening possible using laser mass spectrometry Laser desorption mass spectrometry is emerging as a new tool for screening populations for various genetic diseases Contact: Billy Stair
19-Jun-2001
Protein identification by mass spectrometry ORNL researchers are improving mass spectrometry tools to speed up protein identification and to screen for disease-causing proteins and bacteria. Contact: Billy Stair
19-Jun-2001
Surprises in the mouse genome In the live organism, not all mouse and human genes have predictable functions, and proteins with similar structures can have different functions. Contact: Billy Stair
18-Jun-2001
Search for signs of inflammatory disease You fall on your shoulder and tear some cartilage, causing bone to rub against bone. Your shoulder becomes inflamed and begins to hurt because cytokine, a small signal protein secreted by your immune system, has recruited white blood cells to clean up the damage. Contact: Billy Stair
18-Jun-2001
Curing cancer in mice ORNL researchers have shown that a radioisotope-bearing antibody can target the blood vessels of lung tumors in mice, destroying the tumors. Contact: Billy Stair
18-Jun-2001
MicroCAT 'sees' hidden mouse defects ORNL's X-ray computed tomography system allows internal defects and organ changes in small animals to be mapped. Contact: Billy Stair
18-Jun-2001
Obesity-related gene in mouse discovered at ORNL Some mice born at ORNL have grown dangerously fat, even though they have been on a low-fat diet since birth. Although they do not appear overweight, these mice have a mutated gene that plays a strong role in causing obesity in the form of internal fat deposits that are hazardous to their health. Contact: Billy Stair
18-Jun-2001
Mouse models for the human disease of chronic hereditary tyrosinemia When a section of mouse chromosome 7 containing the coat color c gene is deleted by exposing mice to radiation, "albino" mice are born with a white, hairless coat. Contact: Billy Stair
18-Jun-2001
Searching for mouse models of human Mutant mice are tested by ORNL researchers and their collaborators to determine if these mice have diseases similar to those that afflict humans. Therapies tried on mouse models could lead to new medical treatments. Contact: Billy Stair
18-Jun-2001
Gene chip engineers At ORNL, microarrays are being made faster and cheaper to study gene expression in cells from mice, fish, and other organisms. Contact: Billy Stair
18-Jun-2001
Complex biological systems in mice Using genetic engineering, gene microarrays, and computational technologies, ORNL researchers are deciphering genetic variations in the skin that lead to increased risk of disease from environmental factors. Contact: Billy Stair
18-Jun-2001
Genes and proteins Consider a living cell, the fundamental unit of life. Each human cell contains the entire human genome—some 35,000 genes. But only some genes are expressed within a specific cell, resulting in the production of specific proteins. The genes that turn on in a liver cell, for example, are different from the genes that are expressed in a brain cell. Contact: Billy Stair
1-Jan-2001
Systems biology ORNL scientists are conducting research in functional genomics—the study of genomes to determine the biological function of all the genes and their products—and proteomics—the study of the full set of proteins encoded by a genome. Contact: Billy Stair
19-Dec-2000
Form follows sequence Powerful new computational tools, such as those available at nersc, are playing a key role in deciphering the molecular dynamics of proteins, including creating "movies" of proteins in motion. Contact: Ron Kolb
Contact: Ron Kolb
19-Dec-2000
Picturing proteins Electron microscopy and spectroscopy techniques are making it possible for scientists to create 3-D images of protein complexes that are unsuitable for x-ray crystallography. Contact: Ron Kolb
19-Dec-2000
The crystal robot Innovative robotics designed and built by Lab researchers will grow protein crystals for experimentation at a rate once only dreamed of. Contact: Ron Kolb
19-Dec-2000
The machinery of life Scientists are using Berkeley Lab's state-of-the-art imaging resources to gain new insight into the structure and function of proteins, including those involved in cystic fibrosis. Contact: Ron Kolb
19-Dec-2000
Seeing the cell nucleus in 3-D A new microscopic program called daVinci is helping researchers better understand how breast cancer develops. Contact: Ron Kolb
Showing stories 101-125 out of 126 stories.
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