17-Feb-2015 Study could pave the way for painkillers with fewer side effects
Researchers have long sought alternatives to morphine -- a powerful and widely used painkiller -- that curb its side effects, including dependency, nausea and dizziness. Now, an experiment at the Department of Energy's SLAC National Accelerator Laboratory has supplied the most complete atomic-scale map of such a compound docked with a cellular receptor that regulates the body's pain response and tolerance.
12-Feb-2015 Yonath discusses visualizing ribosomes and antibiotic resistance
Ada Yonath, a pioneer in using crystallographic techniques to visualize ribosome structure, was the most recent Eugene P. Wigner Distinguished Lecturer at the Department of Energy's Oak Ridge National Laboratory. Her work continues to contribute to ribosomal research, prompting researchers to look more closely at antibiotics that target bacterial ribosomes, including those of pathogenic bacteria species, an avenue that could help reverse current levels of antibiotic resistance. At the talk, she steered conversation to species-specific antibiotic resistance.
28-Jan-2015 X-ray study reveals division of labor in cell health protein
Researchers working in part at the Department of Energy's SLAC National Accelerator Laboratory have discovered that a key protein for cell health, which has recently been linked to diabetes, cancer and other diseases, can multitask by having two identical protein parts divide labor.
7-Jan-2015 'Seeing' hydrogen atoms to unveil enzyme catalysis
A multi-institutional research team led by Chris Dealwis from Case Western Reserve University has used the new IMAGINE instrument at Oak Ridge National Laboratory's High Flux Isotope Reactor to map an enzyme that could play an important role in anti-cancer drug development.
18-Dec-2014 Crown ethers flatten in graphene for strong, specific binding
A team led by the Department of Energy's Oak Ridge National Laboratory has discovered a way to dramatically increase the selectivity and binding strength of crown ethers by incorporating them within a rigid framework of graphene. Strong, specific electrostatic binding of crown ethers may advance sensors, chemical separations, nuclear-waste cleanup, extraction of metals from ores, purification and recycling of rare-earth elements, water purification, biotechnology, energy production in durable lithium-ion batteries, catalysis, medicine and data storage.
16-Dec-2014 A standard for neuroscience data
In November, Neurodata without Borders hosted a hackathon to consolidate ideas for designing and implementing a standard neuroscience file format. And BrainFormat, a neuroscience data standardization framework developed at Berkeley Lab, was one of several candidates selected for further investigation. It is now a strong contender to contribute to the development of a community-wide data format and storage standard for the neuroscience research community.
8-Dec-2014 Study may help slow the spread of flu
An important study conducted in part at the Department of Energy's SLAC National Accelerator Laboratory may lead to new, more effective vaccines and medicines by revealing detailed information about how a flu antibody binds to a wide variety of flu viruses.
21-Nov-2014 Robotics meet X-ray lasers in cutting-edge biology studies
Scientists at the Department of Energy's SLAC National Accelerator Laboratory are combining the speed and precision of robots with one of the brightest X-ray lasers on the planet for pioneering studies of proteins important to biology and drug discovery.
17-Oct-2014 Atomic trigger shatters mystery of how glass deforms
A new study at the Department of Energy's Oak Ridge National Laboratory, published Sept. 24 in Nature Communications, has cracked one mystery of glass to shed light on the mechanism that triggers its deformation before shattering. The study improves understanding of glassy deformation and may accelerate broader application of metallic glass, a moldable, wear-resistant, magnetically exploitable material that is thrice as strong as the mightiest steel and ten times as springy.
3-Oct-2014 Accelerating the fight against cancer
As charged-particle therapies grow in popularity, physicists are working with other experts to make them smaller, cheaper and more effective -- and more available to cancer patients in the United States.
11-Apr-2014 Simulation solves mystery of how liquid-crystal thin films disintegrate
Approximately four decades ago, theoreticians believed that only one of two mechanisms could explain rupture of liquid-crystal thin films. They also believed that these two mechanisms could not coexist. But 10 years ago experiments showed that these two mechanisms in many cases do coexist, according to Trung Nguyen of Oak Ridge National Laboratory, who ran unprecedented large-scale molecular dynamics simulations on Titan, America's fastest supercomputer, to model the beginnings of ruptures in thin films.
3-Mar-2014 Particle beam cancer therapy: The promise and challenges
Advances in accelerators built for fundamental physics research have inspired improved cancer treatment facilities. But will one of the most promising -- a carbon ion treatment facility -- be built in the US? Participants at a symposium organized by Brookhaven Lab for the 2014 AAAS meeting explored the science and surrounding issues.
13-Mar-2013 Accelerating particles accelerates science -- with big benefits for society
Tackling the most challenging problems in accelerator science attracts the world's best and brightest to Brookhaven Lab. It's only natural that ideas and techniques born here take root in new research facilities around the world -- and spark a host of spin-off applications for industry, medicine, national security, and more.
The Department of Energy's Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time.