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Computational biology enabling new discoveries to solve complex global problems
Ask any experienced do-it-yourselfer or professional and they'll tell you the importance of using the "right tool for the right job." At Pacific Northwest National Laboratory's Computational and Information Sciences Directorate (CISD), the right tools are powerful high-speed computer systems that are analyzing vast amounts of data and enabling scientists to discover solutions to many complex global problems.

Contact: Lisa Teske
DOE/Pacific Northwest National Laboratory

Environmental biomarkers provide early warning of disease
Outbreaks of Avian flu or "bird flu" during the past several years have disrupted the poultry industry. More ominous is that the virus spreads to humans. The ability to identify this disease early on may help prevent epidemics that wreak havoc on a country's economy and take lives. Now, researchers at Pacific Northwest National Laboratory, through the multi-year Environmental Biomarkers Initiative (EBI), are developing new techniques and tools for identifying these early warning signals also known as environmental biomarkers.

Contact: Lisa Teske
DOE/Pacific Northwest National Laboratory

Still making a mark
One is A. Baha Balantekin, who came to Oak Ridge as a Wigner Fellow in 1984-86 and now, somewhat ironically, holds the Wigner Chair at the University of Wisconsin, where the Nobel Laureate Eugene P. Wigner was once a professor.

Contact: Carolyn H. Krause
DOE/Oak Ridge National Laboratory

Cesium capsules hit cancer harder
A shorter half-life and cesium radiation promise to make cesium-131 capsules harder on cancer and easier on the patient.

Contact: Breakthroughs
DOE/Pacific Northwest National Laboratory

Pacific Northwest lab forms Institute for Interfacial Catalysis, names director
Pacific Northwest National Laboratory today launched an $8 million Institute for Interfacial Catalysis to explore the fundamental chemical changes on surfaces where catalytic reactions take place. The Department of Energy lab also announced the appointment of University of Texas at Austin chemist John M. "Mike" White as the institute's director.

Contact: cannon@pnl.gov
DOE/Pacific Northwest National Laboratory

Landing on it's feet: Hospital reduces patient falls
After accumulating a higher-than-average number of patient falls in recent years, Our Lady of Lourdes Hospital in Pasco, Wash., was able to land on its feet last year with the help of Battelle engineers at Pacific Northwest National Laboratory.

Contact: PNNL Webmaster
DOE/Pacific Northwest National Laboratory

Toxins and pathogens be warned
Imagine munching on a hamburger boldly knowing that it was not contaminated with E. coli or sipping a cold glass of water confident it was truly clean. Due to advances at Pacific Northwest National Laboratory, these ideas may become a reality. A team of PNNL researchers is developing a method to detect contaminants in food, water and air supplies.

Contact: PNNL Webmaster
DOE/Pacific Northwest National Laboratory

Shutting down genes in cancer, bacteria, and viruses
Ribonucleic acid (RNA) interference is a relatively new technique in which small molecules called short interfering RNA (siRNA) can be inserted into cells to turn off a chosen gene.

Contact: Allen Christian
DOE/Lawrence Livermore National Laboratory

Laser burrows into the Earth to destroy land mines
ONE of the great scourges of warfare is the land mine. Although an effective battlefield weapon, land mines kill or maim nearly 45,000 civilians (including 20,000 children) worldwide every year.

Contact: Mark Rotter
DOE/Lawrence Livermore National Laboratory

Detecting bioaerosols when time is of the essence
About seven years ago, Livermore researchers received seed funding from the Laboratory Directed Research and Development Program to develop an instrument that counters bioterrorism by providing a rapid early warning system for pathogens, such as anthrax.

Contact: Richard Langlois
DOE/Lawrence Livermore National Laboratory

Future space scientists train at Brookhaven Lab
As astronauts spend more time in space, scientists need to better understand the dangers space travelers face from deep-space radiation -- and how to best shield them against these risks. A new NASA Summer Student Program at the U.S. Department of Energy's Brookhaven National Laboratory will help provide a "pipeline" of researchers to tackle this challenge. The program begins June 1, 2004

Contact: Karen McNulty Walsh
DOE/Brookhaven National Laboratory

Agricultural biosecurity taking on increased importance
Our current agricultural food safety and security programs have provided the citizens of the U.S. the safest food production system the world has ever seen. But these programs were not designed to identify or respond to intentional acts of bioterrorism using either conventional or unconventional biological agents to contaminate our food or food processing/distribution system.

Contact: Michelle Fleming
DOE/Sandia National Laboratories

SARS foam- Sandia foams fight SARS virus
In a series of tests conducted at Kansas State University on Bovine coronavirus (BCV) -- the internationally accepted surrogate for the Severe Acute Respiratory Syndrome (SARS) coronavirus -- Sandia versions of its DF- 200 formulation fully inactivated samples in one minute or less.

Contact: John German
DOE/Sandia National Laboratories

New medical imaging technique first to use low-dose X-rays to reveal soft tissue
X-rays from the National Synchrotron Light Source at Brookhaven Lab are being employed for the first time in diffraction enhanced imaging, a new, low-dose experimental technique to visualize not only bone, but also soft tissue.

Contact: Zhong Zhong
DOE/Brookhaven National Laboratory

Defending against corrosion
Livermore researchers are designing a rugged system to prevent nuclear wastes from seeping into the environment at the proposed underground repository at Yucca Mountain, Nevada.

Contact: Dan McCright
DOE/Lawrence Livermore National Laboratory

Just say 'no' to adenovirus
Description of research on adenovirus at Brookhaven National Laboratory suggesting that nitric oxide might work as an antiviral agent.

Contact: Karen McNulty Walsh
DOE/Brookhaven National Laboratory

PNNL wins record grant for proteomics center
Pacific Northwest National Laboratory has won a five-year, $10.2 million grant from the National Institutes of Health to support a center for basic research in proteomics. This is the largest NIH award in PNNL's 38-year history.

Contact: PNNL Webmaster
DOE/Pacific Northwest National Laboratory

Stalking the AIDS virus
An improved understanding of the interaction between HIV and the immune system has brought Lab researchers closer to identifying key parameters in AIDS vaccine development.

Contact: Research Quarterly Staff
DOE/Los Alamos National Laboratory

Cadmium quickly causes calcium loss in bones
Researchers at the U.S. Department of Energy's Argonne National Laboratory have demonstrated that cadmium--found in some industrial workplaces and in cigarette smoke--releases calcium from bone within hours of exposure. Knowing how this toxic metal interacts with bone may lead to the screening necessary to detect the early or pre-stages of excess bone loss--before much damage occurs.

Contact: Catherine Foster
DOE/US Department of Energy

Research offers clues to plaques in Alzheimer's disease
Researchers at the U.S. Department of Energy's Argonne National Laboratory and the University of Chicago have made a breakthrough in the study of Alzheimer's disease: discovery of the strategic sites where amino acids can be removed from self-assembling, insoluble peptides that form fibrils in the brains of patients with the disease. With this discovery, researchers can now study the self-assembly process of the entire peptide.

Contact: David Jacque
DOE/US Department of Energy

Secrets of drug resistance revealed
Scientists from the DOE Office of Science's Lawrence Berkeley National Laboratory and the University of California at Berkeley have obtained high-resolution images that offer insight on how bacteria survive attacks from antibiotics. The images were published in the May 9, 2003, issue of Science.

Contact: Dan Krotz
DOE/Lawrence Berkeley National Laboratory

Closing in on cancer
Gerald Small, an Ames Lab senior chemist and an Iowa State University distinguished professor, and Ryszard Jankowiak, an Ames Lab senior scientist, have developed a unique biosensor technology that provides immediate information about DNA damage from cancer-causing pollutants called carcinogens. Damage to DNA, which carries the genetic code of life, is a critical first step in the development of cancer.

Contact: Steve Karsjen
DOE/Ames Laboratory

Artificial retina project
U.S. Department of Energy Secretary Spencer Abraham toured Doheny Eye Institute at the University of Southern California, lauding scientific and engineering breakthroughs in developing an implantable artificial retina for patients with vision loss from retinal diseases such as retinitis pigmentosa and age-related macular degeneration.

Contact: Jeff Sherwood
DOE/US Department of Energy

Scientists identify role of important cancer protein
Scientists from the U.S. Department of Energy's National Synchrotron Light Source located at Brookhaven National Laboratory have uncovered how a known cancer protein disrupts the normal function of human cells. This discovery, which may lead to the design of new anticancer drugs, is reported in the November 1, 2002, issue of the journal Cell.

Contact: Karen McNulty Walsh
DOE/Brookhaven National Laboratory

Security technologies meet the needs of industry
A device that identifies contents in sealed containers and a system that can diagnose engine problems while the equipment is operating are among several innovative technologies developed for national security applications and moved into the marketplace by Pacific Northwest National Laboratory. PNNL conducts scientific research in energy, the environment, national security, information technology and health, making an effort to commercialize technologies so they can help solve critical problems for industry and society.

Contact: Ginny Sliman
DOE/Pacific Northwest National Laboratory

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