Public Release: 8-Feb-2016
Nature Structural & Molecular Biology Scientists propose 'pumpjack' mechanism for splitting and copying DNA
New close-up images of the proteins that copy DNA inside the nucleus of a cell have led a team of scientists to propose a brand new mechanism for how this molecular machinery works. The scientists studied proteins from yeast cells, which share many features with the cells of complex organisms such as humans, and could offer new insight into ways that DNA replication can go awry.
National Institutes of Health, Howard Hughes Medical Institute, Brookhaven Lab Biology Department
Public Release: 28-Jan-2016 PNNL moves cybersecurity software and a novel disinfecting system beyond the lab
Software that helps cybersecurity analysts prevent hacks and a microbial disinfecting system that kills with an activated salt spray are two of the latest innovations Pacific Northwest National Laboratory has successfully commercialized with the help of business partners. The Federal Laboratory Consortium has honored the two teams with 2016 Excellence in Technology Transfer awards.
Department of Energy
Public Release: 26-Jan-2016
2015 GPU Technology Conference Titan targets tumors
Researchers at the German research laboratory Helmholtz-Zentrum Dresden Rossendorf are using Titan to understand and control new methods for particle acceleration that could have big impacts on laser-driven tumor removal.
Helmholtz-Zentrum Dresden-Rossendorf, US Department of Energy
Public Release: 16-Dec-2015
Nature Communications Diamonds may be the key to future NMR/MRI technologies
Berkeley Lab researchers have demonstrated that diamonds may hold the key to the future for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) technologies. NMR/MRI signals were significantly strengthened through the hyperpolarization of carbon-13 nuclei in diamond using microwaves.
US Department of Energy Office of Science
Public Release: 16-Dec-2015
Journal of Breast Cancer Research and Treatment New weapon in the fight against breast cancer
Berkeley Lab researchers have developed the first clinically-relevant mouse model of human breast cancer to successfully express functional estrogen receptor positive adenocarcinomas.
This model should be a powerful tool for testing therapies for aggressive ER+ breast cancers and for studying luminal cancers -- the most prevalent and deadliest forms of breast cancer.
NIH/National Cancer Institute
Public Release: 14-Dec-2015 Portable MRI named Top 10 Breakthrough of 2015 by Physics World magazine
Los Alamos National Laboratory's portable MRI was named one of the Top 10 Breakthroughs of the Year by Physics World, the member magazine of the Institute of Physics. Portable MRI, also called Battlefield MRI (bMRI), uses ultra-low-field magnetic resonance imaging to create images of injured soft tissues, such as the brain.
Public Release: 7-Dec-2015 A cure for medical researchers' big data headache
Oak Ridge Graph Analytics for Medical Innovation (ORiGAMI), supplies researchers with an advanced data tool for literature-based discovery that has the potential to accelerate medical research and discovery. The result of collaboration between Oak Ridge National Laboratory and the US National Library of Medicine, ORiGAMI unites three emerging technologies that are shaping the future of health care: big data, graph computing, and the Semantic Web.
Public Release: 7-Dec-2015
Scientific Reports New clues for battling botulism
Scientists have discovered new details about how 'cloaking' proteins protect the toxin that causes botulism, a fatal disease caused most commonly by consuming improperly canned foods. That knowledge and the cloaking proteins themselves might now be turned against the toxin -- the deadliest known to humankind.
Defense Threat Reduction Agency, National Institutes of Health, DOE Office of Science
Public Release: 3-Dec-2015 Livermore Lab researchers use 3-D printing to build human physiology outside the body
The cardiovascular system is a complex web of tens of thousands of miles of arteries, capillaries and veins, branching throughout the body like tributaries of a great river. And now, researchers at Lawrence Livermore National Laboratory are recapitulating this intricate network using an emerging technology: 3-D bioprinting.
Public Release: 19-Nov-2015
Journal of Controlled Release Nanocarriers may carry new hope for brain cancer therapy
Berkeley Lab researchers have developed a new family of nanocarriers, called '3HM,' that meets all the size and stability requirements for effectively delivering therapeutic drugs to the brain for the treatment of a deadly form of cancer known as glioblastoma multiforme.
National Institutes of Health
Public Release: 17-Nov-2015
PLOS ONE Scientists find bone protein inhibits prostate cancer invasion
Scientists from Lawrence Livermore National Laboratory in collaboration with researchers from University of California campuses at Merced and Davis have found that a secreted protein predominantly expressed in bone inhibits prostate cancer metastasis to bone.
Public Release: 16-Nov-2015 Pacific Northwest National Laboratory scientists win 5 R&D 100 awards
Technologies that impact cyber security, increase our ability to detect trace amounts of chemicals, convert sewage into fuel, view energy processes under real-world conditions and forecast future electric needs are among the newest R&D 100 award winners.
US Department of Energy, and others
Public Release: 2-Nov-2015
Nature Structural & Molecular Biology First complete pictures of cells' DNA-copying machinery
The first-ever images of the protein complex that unwinds, splits, and copies double-stranded DNA reveal something rather different from the standard textbook view. The electron microscope images, created by scientists at the US Department of Energy's Brookhaven National Laboratory with partners from Stony Brook University and Rockefeller University, offer new insight into how this molecular machinery functions.
National Institutes of Health
Public Release: 22-Oct-2015
Nature It takes a thief
The discovery by Berkeley Lab researchers of the structural basis by which bacteria are able to capture genetic information from viruses and other foreign invaders for use in their own immunological system holds promise for studying or correcting problems in human genomes.
National Science Foundation
Public Release: 21-Oct-2015 Berkeley Lab scientists to help build world's first total-body PET scanner
Scientists from Berkeley Lab have set out to help build the world's first total-body positron emission tomography scanner, a medical imaging device that could change the way cancers and other diseases are diagnosed and treated. The project is a consortium led by a UC Davis research team and includes scientists from Berkeley Lab and the University of Pennsylvania. It's supported by a recently announced five-year, $15.5 million Transformative Research Award from the National Institutes of Health.
National Institutes of Health
Public Release: 14-Oct-2015
SC15 Flowing toward red blood cell breakthroughs
A team led by Brown's George Karniadakis is using the Titan supercomputer at the Oak Ridge Leadership Computing Facility to simulate hundreds of millions of red blood cells in an attempt to develop better drug delivery methods and predictors to fight against tumor formation and sickle cell anemia.
US Department of Energy, National Institutes of Health
Public Release: 17-Aug-2015
Nature Scientists discover atomic-resolution details of brain signaling
Scientists have revealed never-before-seen details of how our brain sends rapid-fire messages between its cells. They mapped the 3-D atomic structure of a two-part protein complex that controls the release of signaling chemicals, called neurotransmitters, from brain cells. Understanding how cells release those signals in less than one-thousandth of a second could help launch a new wave of research on drugs for treating brain disorders.
Public Release: 13-Aug-2015 Sandia teams with industry to improve human-data interaction
Sandia National Laboratories and EyeTracking Inc. are researching computer information systems to make national security analysts better at getting meaningful information from large data sets coming in quickly in high-stress environments.
The Department of Energy's Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time.