Public Release: 14-May-2015
Nano Letters CLAIRE brings electron microscopy to soft materials
Berkeley Lab researchers, working at the Molecular Foundry, have invented a technique called 'CLAIRE' that extends the incredible resolution of electron microscopy to the noninvasive nanoscale imaging of soft matter, including biomolecules.
US Department of Energy Office of Science, National Science Foundation
Public Release: 13-May-2015
Blood Starving cancer cells instead of feeding them poison
An enzyme-drug that prevents the essential nutrient asparagine from reaching cancer cells seem an effective way to kill them, but that enzyme-drug also does away with the nutrient glutamine that all cells need. Now a simulation has directed the mutation of the enzyme so that, in wet labs, it left normal cells unharmed in Petri dishes and cancer cells dead in test tubes. Lab tests are underway with mice. If successful, human tests are next.
Sandia National Laboratories' Laboratory-Directed Research and Development
Public Release: 23-Apr-2015
Cell X-ray study may aid in designing better blood pressure drugs
An experiment at the Department of Energy's SLAC National Accelerator Laboratory has revealed in atomic detail how a hypertension drug binds to a cellular receptor that plays a key role in regulating blood pressure. The results could help scientists design new drugs that better control blood pressure while limiting side effects.
Public Release: 14-Apr-2015
Solar Energy Materials and Solar Cells New 'cool roof time machine' will accelerate cool roof deployment
A collaboration led by Berkeley Lab scientists has established a method to simulate in the lab the soiling and weathering of roofing materials, reproducing in only a few days the solar reflectance of roofing products naturally aged for three years. Now this protocol has been approved by American Society for Testing and Materials International as a standard practice for the industry.
US Deptartment of Energy
Public Release: 13-Apr-2015
Proceedings of the National Academy of Sciences X-ray ptychography, fluorescence microscopy combo sheds new light on trace elements
Scientists have developed a new approach that combines ptychographic X-ray imaging and fluorescence microscopy to study the important role trace elements play in biological functions on hydrated cells.
National Institutes of Health, US Department of Energy, National Center for Research Resources
Public Release: 8-Apr-2015
Nature Improved understanding of protein complex offers insight into DNA replication initiation mechanism basics
A clearer understanding of the origin recognition complex -- a protein complex that directs DNA replication -- through its crystal structure offers new insight into fundamental mechanisms of DNA replication initiation. This will also provide insight into how ORC may be compromised in a subset of patients with Meier-Gorlin syndrome, a form of dwarfism in humans.
National Institutes of Health, US Department of Energy
Public Release: 2-Apr-2015 Analytical innovations bring $10 million back to national laboratory, Battelle
A suite of analytical innovations used to detect and measure very low levels of compounds and elements has topped $10 million in licensing income for Pacific Northwest National Laboratory and its operator Battelle. It's the first time that income tied to a specific technology developed at PNNL has reached this level.
Public Release: 19-Mar-2015 Sandia showcases biology breakthroughs available for licensing
Technologies developed in Sandia National Laboratories' biosciences program could soon find their way into doctors' offices -- devices like wearable microneedles that continuously analyze electrolyte levels and a lab-on-a-disk that can test a drop of blood for 64 different diseases in minutes. At a recent seminar for potential investors and licensees, part of the Sandia Technology Showcase series, Sandia bioscientists presented eight ready-to-license technologies in three key areas: medical diagnostics, biosurveillance and therapeutics and drug discovery.
Public Release: 18-Mar-2015
Nucleic Acids Research Los Alamos creates bioinformatics tool for metagenome analysis
Scientists at Los Alamos National Laboratory have developed a new method for DNA analysis of microbial communities such as those found in the ocean, the soil, and our own guts.
Defense Threat Reduction Agency/Chemical and Biological Technologies-Joint Science and Technology Office
Public Release: 10-Mar-2015
Scientific Reports New clues about the risk of cancer from low-dose radiation
Berkeley Lab scientists studied mice and found their risk of mammary cancer from low-dose radiation depends a great deal on their genetic makeup. They also learned key details about how genes and the cells immediately surrounding a tumor (also called the tumor microenvironment) affect cancer risk.
Public Release: 4-Mar-2015 Argonne research expanding from injectors to inhalers
In collaboration with Australian researchers, Argonne's scientists are using decades of experience analyzing vehicle fuel injectors to study medical inhalers, hoping to unlock the secrets of the devices that are so well known to asthma sufferers everywhere.
Public Release: 11-Feb-2015 ORNL's Roberto named MRS Fellow
James Roberto, the associate laboratory director for Science and Technology Partnerships at the Oak Ridge National Laboratory, has been elected a fellow of the Materials Research Society.
Public Release: 29-Jan-2015
Science New clues about a brain protein with high affinity for Valium
Valium, one of the best known antianxiety drugs, produces its calming effects by binding with a particular protein in the brain. But the drug has an almost equally strong affinity for a completely different protein. New studies revealing atomic level details of this secondary interaction might offer clues about Valium's side effects and point the way to more effective drugs.
National Institutes of Health, New York Structural Biology Center, DOE/Office of Science
Public Release: 27-Jan-2015
Toxicology and Applied Pharmacology Man trumps dog: Earlier assumption about BPA exposure confirmed
Coating the mouth with BPA-containing food, like soup, does not lead to higher than expected levels of BPA in blood, a new study in Toxicology and Applied Pharmacology shows. The study authors conclude that oral exposure does not create a risk for high exposures of BPA, also known as bisphenol A.
American Chemistry Council
Public Release: 22-Dec-2014
Nature Methods Mysteries of 'molecular machines' revealed
Scientists are making it easier for pharmaceutical companies and researchers to see the detailed inner workings of molecular machines.
Public Release: 18-Dec-2014
Nature Chemistry Stunning zinc fireworks when egg meets sperm
Zinc flux plays a central role in regulating the biochemical processes that ensure a healthy egg-to-embryo transition, and this new unprecedented quantitative information should be useful in improving in vitro fertilization methods.
National Institutes of Health, US Department of Energy
Public Release: 8-Dec-2014
Nature Communications Turning biological cells to stone improves cancer and stem cell research
A simple technique that creates near-perfect, robust models of human and animal cells is being used to study cancer and stem cells, and could be used to create complex durable structures without the use of machinery.
US Department of Energy's Basic Energy Sciences
Public Release: 26-Nov-2014
Proceedings of the National Academy of Sciences Copper on the brain at rest
A new study by Berkeley Lab researchers has shown that proper copper levels are essential to the health of the brain at rest.
National Institutes of Health and Howard Hughes Medical Institute
Public Release: 3-Nov-2014
Environmental Science & Technology Thirdhand smoke: Toxic airborne pollutants linger long after the smoke clears
Scientists at Lawrence Berkeley National Laboratory have published a new study assessing the health effects of thirdhand smoke constituents present in indoor air. Looking at levels of more than 50 volatile organic compounds and airborne particles for 18 hours after smoking had taken place, they found that thirdhand smoke continues to have harmful health impacts for many hours after a cigarette has been extinguished.
University of California's Tobacco-Related Disease Research Program
Public Release: 31-Oct-2014
168th Meeting of the Acoustical Society of America Are my muscular dystrophy drugs working?
People with muscular dystrophy could one day assess the effectiveness of their medication with the help of a smartphone-linked device, a new study in mice suggests. The study used a new method to process ultrasound imaging information that could lead to hand-held instruments that provide fast, convenient medical information.
National Institutes of Health, National Science Foundation
Public Release: 15-Oct-2014
Genes and Development Key moment mapped in assembly of DNA-splitting molecular machine
Scientists reveal crucial steps and surprising structures in the genesis of the enzyme that divides the DNA double helix during cell replication.
National Institutes of Health, United Kingdom Medical Research Council
The Department of Energy's Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time.