Public Release: 20-Dec-2013
Proceedings of the National Academy of Sciences
A wrong molecular turn leads down the path to Type 2 diabetes
Computing resources at the US Department of Energy's Argonne National Laboratory have helped researchers better grasp how proteins misfold to create the tissue-damaging structures that lead to type 2 diabetes. The structures, called amyloid fibrils, are also implicated in neurodegenerative conditions such as Alzheimer's and Parkinson's, and in prion diseases like Creutzfeldt-Jacob and mad cow disease.
US Department of Energy Office of Science
Public Release: 19-Dec-2013
X-ray laser maps important drug target
Researchers have used one of the brightest X-ray sources on the planet to map the 3-D structure of an important cellular gatekeeper known as a G protein-coupled receptor, or GPCR, in a more natural state than possible before.
US Department of Energy