Uric Acid, Gout and Kidney Disease (IMAGE) Bentham Science Publishers Caption Hyperuricemia and gout are commonly associated with both acute chronic kidney disease. Common to both conditions is stimulation of the innate immune system with activation of the NLRP3 inflammasone, generation of IL-1β and IL-18, and release of cytokines and chemokines. Credit Vandana Dua Niyyar, MD, Bentham Science Publishers Usage Restrictions Copyrights belong to Vandana Dua Niyyar, MD License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.