KRAB Silencing Activity in Target Gene (VIDEO)
Caption
By combining synthetic biology approaches with time-lapse movies that track the behaviors of individual cells, a team led by Caltech biologists has determined how four members of a class of proteins known as chromatin regulators establish and control a cell's ability to maintain a particular state of gene expression. In this movie, recruitment of KRAB (one of the four regulators tested by the group) completely silences, or turns off, the target gene, which codes for a fluorescent protein. Cells with active genes appear green. Note that most cells go dark within a narrow window of time.
Credit
L. Bintu, J. Yong, and M.B. Elowitz / Caltech
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